DNA repair deficiencies and neurodegeneration
DNA Repair (Amst). 2024 Apr 16;138:103679. doi: 10.1016/j.dnarep.2024.103679. Online ahead of print.ABSTRACTNeurodegenerative diseases are the second most prevalent cause of death in industrialized countries. Alzheimer's Disease is the most widespread and also most acknowledged form of dementia today. Together with Parkinson's Disease they account for over 90 % cases of neurodegenerative disorders caused by proteopathies. Far less known are the neurodegenerative pathologies in DNA repair deficiency syndromes. Such diseases like Cockayne - or Werner Syndrome are described as progeroid syndromes - diseases that cause the pre...
Source: DNA Repair - April 19, 2024 Category: Genetics & Stem Cells Authors: Baptiste Ropert Christian Gallrein Bj örn Schumacher Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
CometChip enables parallel analysis of multiple DNA repair activities [DNA repair 106 (2021) 103176-103202]
DNA Repair (Amst). 2024 Apr 5;138:103677. doi: 10.1016/j.dnarep.2024.103677. Online ahead of print.NO ABSTRACTPMID:38582050 | DOI:10.1016/j.dnarep.2024.103677 (Source: DNA Repair)
Source: DNA Repair - April 6, 2024 Category: Genetics & Stem Cells Authors: Jing Ge Le P Ngo Simran Kaushal Ian J Tay Elina Thadhani Jennifer E Kay Patrizia Mazzucato Danielle Chow Jessica Fessler David M Weingeist Robert W Sobol Leona D Samson Scott R Floyd Bevin P Engelward Source Type: research
What are the DNA lesions underlying formaldehyde toxicity?
DNA Repair (Amst). 2024 Mar 7;138:103667. doi: 10.1016/j.dnarep.2024.103667. Online ahead of print.ABSTRACTFormaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and des...
Source: DNA Repair - March 30, 2024 Category: Genetics & Stem Cells Authors: Bente Benedict Stella Munkholm Kristensen Julien P Duxin Source Type: research
What are the DNA lesions underlying formaldehyde toxicity?
DNA Repair (Amst). 2024 Mar 7;138:103667. doi: 10.1016/j.dnarep.2024.103667. Online ahead of print.ABSTRACTFormaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and des...
Source: DNA Repair - March 30, 2024 Category: Genetics & Stem Cells Authors: Bente Benedict Stella Munkholm Kristensen Julien P Duxin Source Type: research
What are the DNA lesions underlying formaldehyde toxicity?
DNA Repair (Amst). 2024 Mar 7;138:103667. doi: 10.1016/j.dnarep.2024.103667. Online ahead of print.ABSTRACTFormaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and des...
Source: DNA Repair - March 30, 2024 Category: Genetics & Stem Cells Authors: Bente Benedict Stella Munkholm Kristensen Julien P Duxin Source Type: research
What are the DNA lesions underlying formaldehyde toxicity?
DNA Repair (Amst). 2024 Mar 7;138:103667. doi: 10.1016/j.dnarep.2024.103667. Online ahead of print.ABSTRACTFormaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and des...
Source: DNA Repair - March 30, 2024 Category: Genetics & Stem Cells Authors: Bente Benedict Stella Munkholm Kristensen Julien P Duxin Source Type: research
What are the DNA lesions underlying formaldehyde toxicity?
DNA Repair (Amst). 2024 Mar 7;138:103667. doi: 10.1016/j.dnarep.2024.103667. Online ahead of print.ABSTRACTFormaldehyde is a highly reactive organic compound. Humans can be exposed to exogenous sources of formaldehyde, but formaldehyde is also produced endogenously as a byproduct of cellular metabolism. Because formaldehyde can react with DNA, it is considered a major endogenous source of DNA damage. However, the nature of the lesions underlying formaldehyde toxicity in cells remains vastly unknown. Here, we review the current knowledge of the different types of nucleic acid lesions that are induced by formaldehyde and des...
Source: DNA Repair - March 30, 2024 Category: Genetics & Stem Cells Authors: Bente Benedict Stella Munkholm Kristensen Julien P Duxin Source Type: research
