Twin-screw extrusion encapsulation of MCT-oil in a maltodextrin matrix using compatibilizing biopolymers.
Abstract Carbohydrates are the most recurrent materials employed for active components encapsulation using twin-screw extrusion. However, the influence of process parameters on the properties of the final product remains a challenge. In this paper, special attention was given to the incorporation of a hydrophobic model compound (MCT-oil), in a maltodextrin matrix with a compatibilizing biopolymer. The effects of the extrusion parameters, as well as the influence of different formulations were analyzed. The mild extrusion conditions allowed obtaining blends with acceptable texture and viscosity to enhance the dispe...
Source: Colloids and Surfaces - July 24, 2020 Category: Biotechnology Authors: Castro N, Durrieu V, Raynaud C, Rouilly A Tags: Colloids Surf B Biointerfaces Source Type: research
Production and characterization of bacterial cellulose membranes with hyaluronic acid and silk sericin.
In this study, BC was functionalized with hyaluronic acid (HA) and silk sericin (SS) using the in situ and ex situ methods. Fourier transform infrared spectroscopy (FTIR) showed that the HA and SS were successfully integrated into the BC membrane. The X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis revealed that the novel BC-HA/SS composites had a typical type I cellulose crystalline form with nanodimensional network, and microfibrils. The roughness of the hybrid membranes was analyzed by atomic force microscopy (AFM). Thermogravimetric analysis showed that the thermal stability of the ex situ modif...
Source: Colloids and Surfaces - July 24, 2020 Category: Biotechnology Authors: Wang X, Tang J, Huang J, Hui M Tags: Colloids Surf B Biointerfaces Source Type: research
Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing.
Abstract During injury or diseased condition, wound dressing fails to properly integrate or repair the tissue and restore its function due to various factors like poor bioavailability, systemic delivery of hydrophobic drugs and elevated levels of reactive oxygen species. Here, we fabricated a novel nano-hybrid hydrogel system, based-on gelatin and oxidized dextran, embedded with nano-formulation of curcumin and cerium oxide, dispersed by physical interaction within the hydrogel. The curcumin was entrapped in amphiphilic alkylated-dextran nanoparticles to enhance its bioavailability and release at the injured site ...
Source: Colloids and Surfaces - July 18, 2020 Category: Biotechnology Authors: Andrabi SM, Majumder S, Gupta KC, Kumar A Tags: Colloids Surf B Biointerfaces Source Type: research
Effects of the crystallinity on quercetin loaded the Eudragit L-100 electrospun nanofibers.
Abstract The quercetin loaded Eudragit L-100 nanofiber membrane with high ductility and a desired drug release rate was prepared in this work. The morphological characteristics of the Eudragit L-100 nanofibers with different drug loadings amount were observed by scanning electron microscope (SEM). After adding Polyethylene glycol-4000 (PEG-4000), the degree of the fiber breakage decreased and the fiber length increased. Fiber diameter analysis, X-ray diffraction (XRD), thermal analysis (TA) and differential scanning calorimetry (DSC) have demonstrated that the crystallinity of the fiber membrane was significantly ...
Source: Colloids and Surfaces - July 17, 2020 Category: Biotechnology Authors: Ao F, Shen W, Ge X, Wang L, Ning Y, Ren H, Fan G, Huang M Tags: Colloids Surf B Biointerfaces Source Type: research
Understanding the adsorption and potential tear film stability properties of recombinant human lubricin and bovine submaxillary mucins in an in vitro tear film model.
Abstract The wetting and adsorption properties for two glycoproteins, recombinant human lubricin and bovine submaxillary mucins (BSM) were evaluated on hydrophilic and hydrophobic glass dome surfaces in a simplified in vitro tear film model. We show that both recombinant human lubricin (rh-lubricin) and BSM solutions render surfaces hydrophilic and when the fluid films reach 500 nm or less, the fluids resist evaporation-driven breakup through a volumetric flux across the surface, which we believe is due to evaporation-driven solutocapillary flows. rh-Lubricin was able to maintain a wet film without spontaneous b...
Source: Colloids and Surfaces - July 16, 2020 Category: Biotechnology Authors: Rabiah NI, Sato Y, Kannan A, Kress W, Straube F, Fuller GG Tags: Colloids Surf B Biointerfaces Source Type: research
Enhancement in β-galactosidase activity of Streptococcus lactis cells by entrapping in microcapsules comprising of correlated silica nanoparticles.
In this study cells of Streptococcus lactis expressing β-galactosidase activity were entrapped in silica microcapsules using evaporation induced assembly through spray drying technique. These microcapsules were characterized using complementary techniques of electron microscopy and neutron/X-ray scattering. Under optimized conditions of spray drying process, the cells immobilized in silica microcapsules had higher biocatalytic activity than the free cells. Immobilized cells showed threefold increase in enzyme activity than free cells. Free cells and immobilized Streptococcus lactis cells exhibited pH optimum at 5.0 an...
Source: Colloids and Surfaces - July 16, 2020 Category: Biotechnology Authors: Mukundan S, Melo JS, Sen D, Bahadur J Tags: Colloids Surf B Biointerfaces Source Type: research
Pluronic ® F127 stabilized reduced graphene oxide hydrogel for transdermal delivery of ondansetron: Ex vivo and animal studies.
Pluronic® F127 stabilized reduced graphene oxide hydrogel for transdermal delivery of ondansetron: Ex vivo and animal studies. Colloids Surf B Biointerfaces. 2020 Jul 13;195:111259 Authors: Li H, Jia Y, Liu C Abstract Ondansetron which is used to manage vertigo, nausea and vomiting suffer from the major limitations of low oral bioavailability (60 %) and short half-life (3-4 h), which affects the routine life style of patients (noncompliance due to multiple dosing). The present work aim to developed ondansetron loaded Pluronic® F127 stabilized reduced graphene oxide hydrogel (2 % Carbopol 940...
Source: Colloids and Surfaces - July 13, 2020 Category: Biotechnology Authors: Li H, Jia Y, Liu C Tags: Colloids Surf B Biointerfaces Source Type: research
Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery.
Abstract Recently, injectable hydrogels have shown great potential in cell therapy and drug delivery. They can easily fill in any irregular-shaped defects and remain in desired positions after implantation using minimally invasive strategies. Here, we developed hydrogels prepared from tilapia skin collagen and chitosan (HCC). The residual mass rate of HCC was affected by the pH at the time of preparation, which was 29.1 % at pH 7 in 36 h. By comparison, the residual mass ratios of HCC at pH values of 6 and 5 were only approximately 8.4 % and 0, respectively. In addition, the stability of HCC was also affected by...
Source: Colloids and Surfaces - July 13, 2020 Category: Biotechnology Authors: Fan X, Liang Y, Cui Y, Li F, Sun Y, Yang J, Song H, Bao Z, Nian R Tags: Colloids Surf B Biointerfaces Source Type: research
Increasing the effectiveness of oxaliplatin using colloidal immunoglobulin G nanoparticles: Synthesis, cytotoxicity, interaction, and release studies.
In this study, gene expression was investigated using real time PCR, which verified IgGNP induced programmed cell death in MCF-7 breast cancer cell more effectively than free OX. Subsequently, a novel nano scale biological macromolecule can be introduced as a sustained and prolonged anticancer drug release. PMID: 32683237 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - July 13, 2020 Category: Biotechnology Authors: Shahlaei M, Saeidifar M, Zamanian A Tags: Colloids Surf B Biointerfaces Source Type: research
Effect of varied hair protein fractions on the gel properties of keratin/chitosan hydrogels for the use in tissue engineering.
Abstract Keratin/chitosan composite is a readily available source for a hybrid hydrogel in tissue engineering. While human hair keratins could provide biological functions, chitosan could further enhance the mechanical strength of the hybrid hydrogels. However, hair keratin is a group of natural proteins, and the uncontrolled hair protein contents in a hydrogel may lead to the batch-to-batch inconsistent gel properties. The purpose of this study was to investigate the role of hair protein composition, including the keratin-associated proteins (KAPs, 6-30 kDa) and keratin intermediate filaments (KIFs, 45-60 kDa...
Source: Colloids and Surfaces - July 13, 2020 Category: Biotechnology Authors: Lu TY, Huang WC, Chen Y, Baskaran N, Yu J, Wei Y Tags: Colloids Surf B Biointerfaces Source Type: research
Hybrid micelles based on Pt (IV) polymeric prodrug and TPGS for the enhanced cytotoxicity in drug-resistant lung cancer cells.
Abstract Multidrug resistance (MDR) is a primary cause of failure in oncotherapy and interest is growing in the design of multi-stimuli responsive nano-carriers to synergistically deliver chemotherapeutic agents and P-gp inhibitors to reverse MDR. The hybrid micelles based on a Platinum (IV)-coordinate polymeric prodrugs and TPGS were developed to improve chemotherapy and reduce side effects. The pH/redox dual-sensitive polymers were synthesized by condensation polymerization using ortho ester monomer and diamminedichlorodisuccinatoplatinum (DSP). The hybrid micelles possessed uniform size (38 nm) and displ...
Source: Colloids and Surfaces - July 12, 2020 Category: Biotechnology Authors: He L, Xu J, Cheng X, Sun M, Wei B, Xiong N, Song J, Wang X, Tang R Tags: Colloids Surf B Biointerfaces Source Type: research
Developing fluorescent copper nanoclusters: Synthesis, properties, and applications.
Abstract Metal nanoclusters exhibit strong fluorescence emission, providing immense potential for developments in biological labeling and imaging. Copper nanoclusters in particular, due to their unique optical properties such as molecular-like absorption and strong luminescence, represent a novel fluorescent nanomaterial for sensing and bioimaging applications. This review describes research progress on Cu nanoclusters in recent years, investigating the synthesis techniques, their properties, and their promising applications. A concluding summary provides an outlook on the future research challenges for Cu nanoclu...
Source: Colloids and Surfaces - July 11, 2020 Category: Biotechnology Authors: Zhao Z, Li Y Tags: Colloids Surf B Biointerfaces Source Type: research
Enhanced production of volatile fatty acids by adding a kind of sulfate reducing bacteria under alkaline pH.
The objective of this study was to reduced sludge production and realize the resource utilization of VFAs through enhance anaerobic sludge fermentation by adding sulfate reducing bacteria (SRB) under alkaline pH. Under the neutral and alkaline pH, SRB was added into the sludge fermentation liquid with sole stock solution and sterilization treatment respectively, while the liquid without any additives was used as control. The results indicated that obvious increase of the production of VFAs was observed after adding SRB under alkaline pH. And, more protein and polysaccharide were obtained which were the main substrates for ...
Source: Colloids and Surfaces - July 10, 2020 Category: Biotechnology Authors: Wang G, Wang D, Huang L, Song Y, Chen Z, Du M Tags: Colloids Surf B Biointerfaces Source Type: research
An overview of peroxidation reactions using liposomes as model systems and analytical methods as monitoring tools.
lia A Abstract Phospholipids are building blocks of biological membranes having a key role in cellular functionality. The presence of unsaturated fatty acids in their conformation makes them prompt to oxidation reactions, leading to dysfunctions of living cells or to instability of lipid containing food products. The aim of this review is to gather together the latest advances on the understanding on lipids' peroxidation, using liposomes as model systems, including the main available analytical methods to monitor peroxidation reactions, with special emphasis on Fourier Transform Infrared (FTIR) and Raman spectrosc...
Source: Colloids and Surfaces - July 10, 2020 Category: Biotechnology Authors: Faroux JM, Ureta MM, Tymczyszyn EE, Gómez-Zavaglia A Tags: Colloids Surf B Biointerfaces Source Type: research
Mechanism of the biodemulsifier-enhanced biodegradation of phenanthrene by Achromobacter sp. LH-1.
Abstract Biodemulsifiers are widely applied in petroleum processing, mining and petroleum pollution treatment. Polycyclic aromatic hydrocarbons (PAHs) are a common component in petroleum-polluted environments; however, little is known about the mechanism behind the effect of biodemulsifiers on promoting PAH biodegradation. To obtain clear mechanistic insights, the facilitating effects of biodemulsifiers on the bioavailability of phenanthrene (PHE), which is used as a model PAH, and the cell membrane properties of PHE-degrading bacteria Achromobacter sp. LH-1 were researched. The results showed that LH-1 achieved a...
Source: Colloids and Surfaces - July 9, 2020 Category: Biotechnology Authors: Zang H, Dai Y, Sun Y, Jia T, Song Q, Li X, Jiang X, Sui D, Han Z, Li D, Hou N Tags: Colloids Surf B Biointerfaces Source Type: research
Nanozymes used for antimicrobials and their applications.
Abstract Bacterial infection-related diseases have been growing year-by-year rapidly and raising health problems globally. The exploitation of novel, high efficiency, and bacteria-binding antibacterial agents are extremely need. As far as now, the most extensive treatment is restricted to antibiotics, which may be overused and misused, leading to increased multidrug resistance. Antibiotics abuse, as well as antibiotic-resistance of bacteria, is a global challenge in the current situation. It is highly recommended and necessary to develop novel bactericide to kill the bacteria effectively without causing further re...
Source: Colloids and Surfaces - July 9, 2020 Category: Biotechnology Authors: Yang D, Chen Z, Gao Z, Tammina SK, Yang Y Tags: Colloids Surf B Biointerfaces Source Type: research
Effect of curcumin and cosolvents on the micellization of Pluronic F127 in aqueous solution.
h;nnesen HH Abstract The drug solubilization capacity of poloxamers like Pluronic F127 (PF127, poloxamer 407) is dependent on the physical form of the polymer; i.e. the distribution between unimers, aggregates, and micelles. Further, the formation of micelles can alter the stability and pharmacological activity of a drug molecule. It is therefore important to understand how the micellization process is influenced by the addition of excipients and drug molecules. Curcumin is considered a photosensitizer in antimicrobial photodynamic therapy (aPDT). The aPDT effect is optimized at a poloxamer concentration just belo...
Source: Colloids and Surfaces - July 8, 2020 Category: Biotechnology Authors: Thapa RK, Cazzador F, Grønlien KG, Tønnesen HH Tags: Colloids Surf B Biointerfaces Source Type: research
Pluronic ® F127 stabilized reduced graphene oxide hydrogel for the treatment of psoriasis: In vitro and in vivo studies.
Pluronic® F127 stabilized reduced graphene oxide hydrogel for the treatment of psoriasis: In vitro and in vivo studies. Colloids Surf B Biointerfaces. 2020 Jul 07;195:111246 Authors: Li Q, Li F, Qi X, Wei F, Chen H, Wang T Abstract Psoriasis is a chronic inflammatory disease that can be effectively treated using topical cyclosporine. However, topical delivery is extremely challenging owing to the physicochemical nature of cyclosporine, as well as the thick psoriatic stratum corneum. In the present study, for the first time, we attempted to formulate a cyclosporine-loaded Pluronic® F127 stabili...
Source: Colloids and Surfaces - July 7, 2020 Category: Biotechnology Authors: Li Q, Li F, Qi X, Wei F, Chen H, Wang T Tags: Colloids Surf B Biointerfaces Source Type: research
MoS2-ALG-Fe/GOx hydrogel with Fenton catalytic activity for combined cancer photothermal, starvation, and chemodynamic therapy.
In this study, a simple approach was reported to prepare MoS2 and glucose oxidase (GOx)-containing sodium alginate (ALG)-Fe3+ (MAF) hydrogel. In the hydrogel, there exists an enzymatic reaction to consume glucose to form hydrogen peroxide (H2O2), and a redox reaction between Fe3+ and MoS2 to form Fe2+ and MoO42-. The formed Fe2+ could be oxidized to Fe3+, which reacts with MAF hydrogel again to continuously produce Fe2+. The consumption of glucose resulted in an obvious tumor ST. Moreover, the produced Fe2+ induced a Fenton reaction to enable the persistent conversion of H2O2 to cytotoxic hydroxyl radicals (·OH) for...
Source: Colloids and Surfaces - July 4, 2020 Category: Biotechnology Authors: Zhou L, Zhao J, Chen Y, Zheng Y, Li J, Zhao J, Zhang J, Liu Y, Liu X, Wang S Tags: Colloids Surf B Biointerfaces Source Type: research
Silver, copper, and copper hydroxy salt decorated fumed silica hybrid composites as antibacterial agents.
tin O Abstract Decoration of matrices such as silicates, graphene, etc. is an efficient technique in order to develop multifunctional materials with enhanced properties, which are of use for microbial control. Consequently, it leads to an increased search for alternative matrices and synthesis methods for decoration. Herein, decoration of a fumed silica is proposed, with structures that consisted of silver (Ag@FS), copper hydroxy salt (CuHS@FS), and copper (Cu@FS), for antibacterial applications. With the simple combination of the metal precursor salt, the appropriate solvent, and the fumed silica, the composites ...
Source: Colloids and Surfaces - July 3, 2020 Category: Biotechnology Authors: Videira-Quintela D, Guillén F, Montalvo G, Martin O Tags: Colloids Surf B Biointerfaces Source Type: research
Lipid-based Janus nanoparticles for pharmaceutical and cosmetic applications: Kinetics and mechanisms of destabilization with time and temperature.
Abstract The aim of this paper is to investigate the time and thermal stability of innovative multicompartmental nanoparticles. These particles, having a hydrophilic side and a hydrophobic side, belong to the family of Janus particles and are promising tools to carry active ingredients with opposite solubilities in a unique nanocarrier. The stability of nanoparticles obtained with mainly two types of polyoxylglycerides (Labrafil® M2125 CS and Labrafil® M1944 CS) has been investigated. The suspensions describe a two-step maturation/destabilization process with an Ostwald ripening phase followed by the coale...
Source: Colloids and Surfaces - July 3, 2020 Category: Biotechnology Authors: Benrabah L, Kemel K, Twarog C, Huang N, Solgadi A, Laugel C, Faivre V Tags: Colloids Surf B Biointerfaces Source Type: research
Fabrication of electrochemical biosensor composed of multi-functional DNA/rhodium nanoplate heterolayer for thyroxine detection in clinical sample.
This study demonstrates the possibility of label-free detection of the T4 with multi-functional DNA/pRhNPs heterolayer that can be applied to small molecule detection platform in the near future. PMID: 32652400 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - July 2, 2020 Category: Biotechnology Authors: Park SY, Kim J, Yim G, Jang H, Lee Y, Kim SM, Park C, Lee MH, Lee T Tags: Colloids Surf B Biointerfaces Source Type: research
Effects of inner polarity and viscosity of amphiphilic phospholipid polymer aggregates on the solubility enhancement of poorly water-soluble drugs.
Abstract We quantitatively evaluated the properties of aggregates of amphiphilic polymers formed in an aqueous medium and clarified the effect of the inside polarity and viscosity of the polymer aggregate on the solubilization of poorly water-soluble drugs. Three water-soluble amphiphilic 2-methacryloyloxyethyl phosphorylcholine (MPC) polymers with various hydrophobic monomer units, namely, n-butyl methacrylate (BMA), 2-methacryloyloxyethyl butylurethane (MEBU), and 2-methacryloyloxyethyl benzylurethane (MEBZU), were synthesized. The different molecular interactions between the hydrophobic monomer units, such as h...
Source: Colloids and Surfaces - July 1, 2020 Category: Biotechnology Authors: Yoshie K, Yada S, Ando S, Ishihara K Tags: Colloids Surf B Biointerfaces Source Type: research
Waste of Mytella Falcata shells for removal of a triarylmethane biocide from water: Kinetic, equilibrium, regeneration and thermodynamic studies.
Abstract Waste of Mytella falcata shell was used as low-cost adsorbent to remove the biocide Basic Green 4 (BG4) from water. Shells were collected form trash nearby the lagoon were Mytella falcata is fished. After clean, dry and crushed, the powder was characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and X-ray dispersive energy spectroscopy (EDS). Both kinetic and equilibrium adsorption tests are carried out. Adsorbent regenerability was tested during adsorption/desorption cycles, using a UV photo-regeneration process. The maximum...
Source: Colloids and Surfaces - June 30, 2020 Category: Biotechnology Authors: Quintela DU, Henrique DC, Dos Santos Lins PV, Ide AH, Erto A, Duarte JLDS, Meili L Tags: Colloids Surf B Biointerfaces Source Type: research
Promoted migration of fibroblast cells on low aspect ratio isotropic nanopore surface by reduced maturation of focal adhesion at peripheral region.
Abstract Cell migration plays fundamental roles in the development and maintenance of organisms such as wound healing and embryonic development, and cell migration is affected by the surrounding nanostructure of the extracellular matrix. Many researchers have developed various nanotopographical structures to investigate cell migration behaviors in response to the nanostructures, however, it is hard to draw firm conclusions about a relationship between surface topography and cell migration due to the contradictory results. Here, as one of the possible approaches to investigate the cell migration behaviors on the na...
Source: Colloids and Surfaces - June 30, 2020 Category: Biotechnology Authors: Hwang CY, Kim HW, Yoon H, Kim DS Tags: Colloids Surf B Biointerfaces Source Type: research
Magnetic targeting cobalt nanowire-based multifunctional therapeutic system for anticancer treatment and angiogenesis.
We present herein a magnetic targeting multifunctional anticancer therapeutic system based on cobalt nanowires (CoNWs) for anticancer therapy and angiogenesis. Magnetic characterization shows that the CoNWs can be concentrated in desired locations under the external magnetic field, which is favorable for anticancer target therapy. Besides, drug loading/release characterization reveals that the CoNWs interact with doxorubicin (DOX) by electrostatic interaction, and accordingly form a composite which can release DOX with temperature increase under near-infrared light (NIR) treatment. And anticancer test reveals that the nano...
Source: Colloids and Surfaces - June 27, 2020 Category: Biotechnology Authors: Zhao J, Liu Y, Sun J, Zhu H, Chen Y, Dong T, Sang R, Gao X, Yang W, Deng Y Tags: Colloids Surf B Biointerfaces Source Type: research
Targeted co-delivery of curcumin and doxorubicin by citric acid functionalized Poly ( ε-caprolactone) based micelle in MDA-MB-231 cell.
In conclusion, combinational therapy by using Dox and Cur nano-formulation has boosted the cytotoxicity in MDA-MB231 cells by promoting the apoptotic response. PMID: 32622253 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - June 26, 2020 Category: Biotechnology Authors: Sabzi A, Rahmani A, Edalati M, Kahroba H, Dadpour MR, Salehi R, Zarebkohan A Tags: Colloids Surf B Biointerfaces Source Type: research
ICG-loaded gold nano-bipyramids with NIR activatable dual PTT-PDT therapeutic potential in melanoma cells.
Abstract A great amount of effort is directed towards the progress of cancer treatment approaches aspiring to develop non-invasive, targeted and highly efficient therapies. In this context, Photothermal (PTT) and Photodynamic (PDT) Therapies were proven as promising. This work aims to integrate the therapeutic activities of two near-infrared (NIR) photoactive biomaterials - gold nano-bipyramids (AuBPs) and Indocyanine Green (ICG) - into one single targeted hybrid nanosystem able to operate as dual PTT-PDT agent with higher efficiency compared with each one alone. Firstly, different aspect ratio' AuBPs were systema...
Source: Colloids and Surfaces - June 26, 2020 Category: Biotechnology Authors: Campu A, Focsan M, Lerouge F, Borlan R, Tie L, Rugina D, Astilean S Tags: Colloids Surf B Biointerfaces Source Type: research
Investigating the biomolecular interactions between model proteins and glycine betaine surfactant with reference to the stabilization of emulsions and antimicrobial properties.
In conclusion, the present study revealed that the interaction between DMGM-14 with BSA and HEWL is important for the pharmaceutical, biological, and food products. PMID: 32623332 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - June 26, 2020 Category: Biotechnology Authors: Janek T, Sałek K, Burger J, Czyżnikowska Ż, Euston SR Tags: Colloids Surf B Biointerfaces Source Type: research
ROS triggered cleavage of thioketal moiety to dissociate prodrug nanoparticles for chemotherapy.
Abstract With the utilization of high concentration reactive oxygen species (ROS) in tumor microenvironment, PEG-doxorubicin (PEG-DOX) prodrug was synthesized via a thioketal moiety as the linker, which was ROS cleavable to trigger DOX release from the self-assembled prodrug nanoparticles. The in vitro ROS sensitivity of prodrug nanoparticles (NPs) was investigated in Fenton agent and H2O2, and the disassembly of NPs was more sensitive to Fenton reagent. After internalized in HepG2 cells via endocytosis, the cellular ROS consuming test revealed intracellular DOX release. The pharmacokinetics and biodistribution st...
Source: Colloids and Surfaces - June 25, 2020 Category: Biotechnology Authors: Pan Q, Deng X, Gao W, Chang J, Pu Y, He B Tags: Colloids Surf B Biointerfaces Source Type: research
c-Phycocyanin primed silver nano conjugates: Studies on red blood cell stress resilience mechanism.
Abstract Green synthesis of metal-encased nutraceutical nano-hybrids has been a target for research over the last few years. In the present investigation, we have reported temperature dependent facile synthesis of silver nanoparticles using FDA approved c phycocyanin (cPC). The cPC conjugated silver nanoparticles (AgcPCNPs) were characterized by TEM, Zeta Potential, UV-vis, XPS, FTIR, and CD Spectroscopy. The temperature optimization studies suggested the synthesis of stable AgcPCNPs at 40 °C while at higher temperature system shows aggregated appearance. Molecular docking studies predicted the exclusive inter...
Source: Colloids and Surfaces - June 25, 2020 Category: Biotechnology Authors: Madhyastha H, Madhyastha R, Thakur A, Kentaro S, Dev A, Singh S, Chandrashekharappa R B, Kumar H, Acevedo O, Nakajima Y, Daima HK, Aradhya A, Nagaraj P N, Maruyama M Tags: Colloids Surf B Biointerfaces Source Type: research
Papain immobilized on alginate membrane for wound dressing application.
Abstract Wound dressings based on natural polymers are of considerable interest in the pharmaceutical industry owing to their improved performance in the human body when compared to synthetic polymers. Alginate, a polysaccharide from brown algae, is commonly studied as a wound dressing owing to its biocompatibility and biodegradability. To improve its therapeutic features and thereby increase wound healing, papain (a proteolytic enzyme from Carica papaya latex) was proposed to be incorporated. Papain is capable of promoting the debridement of devitalized or necrotic tissues. The development of dressing based on al...
Source: Colloids and Surfaces - June 25, 2020 Category: Biotechnology Authors: Moreira Filho RNF, Vasconcelos NF, Andrade FK, Rosa MF, Vieira RS Tags: Colloids Surf B Biointerfaces Source Type: research
Effect of fatty acid ester structure on cytotoxicity of self-emulsified nanoemulsion and transport of nanoemulsion droplets.
In conclusion, the FAEs with less intermolecular attraction and straight chain have more cytotoxic and permeation enhancing effects when formulated in nanoemulsion. PMID: 32604040 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - June 25, 2020 Category: Biotechnology Authors: Bunchongprasert K, Shao J Tags: Colloids Surf B Biointerfaces Source Type: research
Promoting 3D neuronal differentiation in hydrogel for spinal cord regeneration.
In this study, we proposed a functional scaffold developed by loading BMSCs and NSCs into 3D GelMA hydrogel. BMSCs and NSCs that were photo-encapsulated in the 3D GelMA hydrogel survived and demonstrated good proliferation in vitro. The NSCs differentiated more toward neurons and oligodendrocytes than toward astrocytes, a phenomenon more noticeable in low-modulus hydrogels. When functional hydrogel scaffolds, loaded with BMSCs and NSCs, were implanted into the hemisection site of the rat spinal cord, they could significantly promote motor function recovery and neuronal differentiation, and decrease glial scarring, fibrotic...
Source: Colloids and Surfaces - June 24, 2020 Category: Biotechnology Authors: Zhou P, Xu P, Guan J, Zhang C, Chang J, Yang F, Xiao H, Sun H, Zhang Z, Wang M, Hu J, Mao Y Tags: Colloids Surf B Biointerfaces Source Type: research
Cell membrane fusing liposomes for cytoplasmic delivery in brain endothelial cells.
Abstract Direct cytoplasmic delivery is essential for susceptible molecules as proteins and some nucleic acids to improve their therapeutic efficacy in cells. Using liposomes for their delivery proved challenging due to known uptake by endocytosis followed by partial or complete lysosomal breakdown. Thus, "fusogenic" liposomes (FL) composed of the neutral lipid dioleoylphosphatidylethanolamine (DOPE) combined with the cationic lipid 1, 2-dioleoyl-3-trimethylammoniumpropane (DOTAP) were tested in different ratios for their cell membrane fusion ability and their cytoplasmic delivery was compared to "p...
Source: Colloids and Surfaces - June 24, 2020 Category: Biotechnology Authors: Farid M, Faber T, Dietrich D, Lamprecht A Tags: Colloids Surf B Biointerfaces Source Type: research
Revitalizing the local anesthetic effect of Mebeverine hydrochloride via encapsulation within ethosomal vesicular system.
In this study, therefore, the efficacy of ethosomes for delivering MBH via skin for local anesthetic effect was investigated. The ethosomes were formulated, optimized and characterized for particle size, zeta potential, entrapment efficiency and in vitro permeation studies. Then, the optimized formula was incorporated into Carbopol 940® gel and evaluated for skin irritation and in vivo local anesthetic action. Ethosomes were spherical in shape with vesicle sizes varied from 308.2 ± 18.2 nm to 78.8 ± 8.6 nm and entrapment efficiencies of 18-65%. In vitro drug perme...
Source: Colloids and Surfaces - June 20, 2020 Category: Biotechnology Authors: Hasan AA, Samir RM, Abu-Zaid SS, Abu Lila AS Tags: Colloids Surf B Biointerfaces Source Type: research
Attenuation of Proteus mirabilis colonization and swarming motility on indwelling urinary catheter by antibiofilm impregnation: An in vitro study.
Abstract Proteus mirabilis is one of the important etiologic agents of urinary tract infections (UTI), which complicates the long-term urinary catheterization process in clinical settings. Owing to its crystalline biofilm forming ability and flagellar motility, elimination of P. mirabilis from urinary system becomes very difficult. Thus, the present study is focused to prepare antibiofilm-impregnated Silicone Foley Catheter (SFC) to prevent P. mirabilis instigated UTIs. Through solvent swelling method, the antibiofilm compounds such as linalool (LIN) and 2-hydroxy-4-methoxy benzaldehyde (HMB) were successfully inf...
Source: Colloids and Surfaces - June 18, 2020 Category: Biotechnology Authors: Durgadevi R, Kaleeshwari R, Swetha TK, Alexpandi R, Karutha Pandian S, Veera Ravi A Tags: Colloids Surf B Biointerfaces Source Type: research
Magnetic stomatocyte-like nanomotor as photosensitizer carrier for photodynamic therapy based cancer treatment.
Abstract Amphiphilic block copolymer can self-assemble to stomatocyte-like structure as drug delivery carrier. Photodynamic therapy (PDT) is an emerging modality for cancer treatment. However, PDT has various problems, such as weak tumor accumulation ability of photosensitizers (PSs), short lifetime of singlet oxygen (1O2, main reactive oxygen species in PDT) and tumor hypoxia microenvironment, to restrict its therapeutic efficacy. To convey PSs to tumor tissues and improve PDT efficacy, iron oxide nanoparticles (IONPs) were loaded inside the self-assembly stomatocytes-like structure of poly(ethylene glycol) block...
Source: Colloids and Surfaces - June 17, 2020 Category: Biotechnology Authors: Zhang P, Wu G, Zhao C, Zhou L, Wang X, Wei S Tags: Colloids Surf B Biointerfaces Source Type: research
Effects of molecular interactions at various polymer brush surfaces on fibronectin adsorption induced cell adhesion.
Abstract The effects of protein adsorption on the polymer brush surfaces with well-defined chemical structures and physical properties were examined with respect to initial protein adsorption, structural changes to the adsorbed proteins, and subsequent cell adhesion. Four polymer brush surfaces with different hydrophilicities and charge states were prepared. The molecular interaction forces during adsorption-desorption processes of protein on the polymer brush surfaces depending on the chemical structure of the polymer were determined. Crucially, these molecular interactions affected the adsorption behavior and st...
Source: Colloids and Surfaces - June 17, 2020 Category: Biotechnology Authors: Ishihara K, Mitera K, Inoue Y, Fukazawa K Tags: Colloids Surf B Biointerfaces Source Type: research
Programmed antibacterial and mineralization therapy for dental caries based on zinc-substituted hydroxyapatite/ alendronate-grafted polyacrylic acid hybrid material.
Abstract The domination of cariogenic bacteria in dental plaque biofilms is the primary cause of dental caries. In view of this, for the purpose of an effective treatment of dental caries, it is of great importance to inhibit the activity of acidogenic bacteria and promote the remineralization of damaged teeth simultaneously. However, the expensive antibacterial agents and poor mineralization ability of materials limit the practical applications. Biomineralization regulated by non-collagenous proteins (NCPs) gives hints to combine the remineralization ability of NCPs with accessible antibacterial property effectiv...
Source: Colloids and Surfaces - June 17, 2020 Category: Biotechnology Authors: Xu X, Wang N, Wu M, Wang J, Wang D, Chen Z, Xie J, Ding C, Li J Tags: Colloids Surf B Biointerfaces Source Type: research
Nanoemulsions: An emerging platform for increasing the efficacy of nutraceuticals in foods.
Abstract Both whole and processed foods contain numerous bioactive substances that improve human health and performance, including macronutrients, micronutrients, and nutraceuticals. Many of these substances are strongly hydrophobic and chemically labile, which can diminish their beneficial health effects, since only a small fraction of the ingested amount is actually absorbed and utilized by the body. In the gastrointestinal tract, the overall bioavailability of a hydrophobic substance is determined by its bioaccessibility, transformation, and absorption. The design of functional foods with enhanced biological ac...
Source: Colloids and Surfaces - June 17, 2020 Category: Biotechnology Authors: Zhang R, Zhang Z, McClements DJ Tags: Colloids Surf B Biointerfaces Source Type: research
Folate targeted PEGylated liposomes for the oral delivery of insulin: In vitro and in vivo studies.
In this study using phospholipids with high transition temperature and taking advantage of PEGylation, we designed liposomal formulation targeted with folic acid (FA) to improve the stability of liposomes with high penetration efficiency at the same time. The results of characterization demonstrated that liposomal formulations are in range of 150-210 nm size with negative surface charge. The results of cell uptake indicated that FA conjugation resulted in the more uptake of insulin. However, the results of transepithelial electrical resistance (TEER) showed no statistical differences among the formulations. The results o...
Source: Colloids and Surfaces - June 17, 2020 Category: Biotechnology Authors: Yazdi JR, Tafaghodi M, Sadri K, Mashreghi M, Nikpoor AR, Nikoofal-Sahlabadi S, Chamani J, Vakili R, Moosavian SA, Jaafari MR Tags: Colloids Surf B Biointerfaces Source Type: research
Influence of silver speciation on the inflammatory regulation of AgNPs anchoring onto titania nanotubes.
This study give a new sight for discovering the inflammatory regulation mechanism of silver containing biomaterials. PMID: 32585536 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - June 16, 2020 Category: Biotechnology Authors: Yang C, Wang Z, Huang K, Weng J, Wang J, Zhou J, Feng B Tags: Colloids Surf B Biointerfaces Source Type: research
Antibacterial properties of Magainin II peptide onto 304 stainless steel surfaces: A comparison study of two dopamine modification methods.
In this study, two modification methods were reported to synthesize antibacterial surfaces based on the different order of Magainin Ⅱ (MAG Ⅱ) modification. The preparation of SS-DA-M was generated by modifying the 304 stainless steel (304 SS) surface with dopamine firstly and then grafting the MAG Ⅱ onto the dopamine modified surface; SS-M-DA was obtained by modifying 304 SS surface using MAG Ⅱ derivative which synthesized by MAG Ⅱ and dopamine under weak acid condition. XPS, contact angle, film thickness and surface topography analysis showed that both methods grafted MAG Ⅱ onto the 304 SS surface successfully...
Source: Colloids and Surfaces - June 16, 2020 Category: Biotechnology Authors: Cao P, Liu K, Liu X, Sun W, Wu D, Yuan C, Bai X, Zhang C Tags: Colloids Surf B Biointerfaces Source Type: research
Enhanced durability, bio-activity and corrosion resistance of stainless steel through severe surface deformation.
Abstract Owing to its good biocompatibility and low cost, stainless steel is one of the most widely utilized biomaterial. However, longtime assessment of stainless steel has shown problems related to material degradation, especially localized corrosion and bio-film formation. In addition, the leaching of toxic nickel and chromium ions from stainless steel leads to additional health complications. Here, we utilized submerged friction stir processing, a severe surface deformation technique for significantly enhancing its durability, bio-activity as well as antibacterial resistance. The processing was done with a wid...
Source: Colloids and Surfaces - June 15, 2020 Category: Biotechnology Authors: Perumal G, Grewal HS, Arora HS Tags: Colloids Surf B Biointerfaces Source Type: research
A novel selective ternary platform fabricated with MgAl-layered double hydroxide/NiMn2O4 functionalized polyaniline nanocomposite deposited on a glassy carbon electrode for electrochemical sensing of levodopa.
In this study, a novel selective electrochemical sensor was fabricated for determination of levodopa (LD) using a glassy carbon electrode modified with MgAl-layered double hydroxide/NiMn2O4 functionalized polyaniline nanocomposite (LDH/NMO/PANI) and its successful formation was conﬁrmed by various techniques. Owing to the high surface area and outstanding conductivity features provided by the combination of MgAl-LDH, NiMn2O4 and PANI nanoparticles, this ternary nanocomposite exhibited excellent electrochemical activity towards the detection of LD compared with the electrode modiﬁed by the pristine MgAl-LDH and MgAl-LDH...
Source: Colloids and Surfaces - June 12, 2020 Category: Biotechnology Authors: Ahmadi-Kashani M, Dehghani H Tags: Colloids Surf B Biointerfaces Source Type: research
Nano-based delivery systems for berberine: A modern anti-cancer herbal medicine.
Abstract Berberine (BBR) is an isoquinoline alkaloid belonging to the structural class of protoberberines. BBR has been used in traditional medicine to treat diseases, such as type 2 diabetes and hypercholesterolemia. BBR inhibits cancer cell growth and induces apoptosis. However, BBR has significant drawbacks as a chemotherapeutic agent, including poor solubility, and induction of drug resistance, limiting its application in chemotherapy. Hence, combination therapy could not only deal with the problems related to single-agent chemotherapy but could also improve the therapeutic index of anticancer drugs. Co-admini...
Source: Colloids and Surfaces - June 8, 2020 Category: Biotechnology Authors: Majidzadeh H, Araj-Khodaei M, Ghaffari M, Torbati M, Ezzati Nazhad Dolatabadi J, Hamblin MR Tags: Colloids Surf B Biointerfaces Source Type: research
Molecular interactions between Vitamin B12 and membrane models: A biophysical study for new insights into the bioavailability of Vitamin.
Abstract Vitamin B12 (VB12) deficiency is one of the most common malnutrition problems worldwide and is related to its poor bioavailability. The lipid composition of cell membranes and molecule-cell membrane lipid interactions are major factors affecting the bioavailability of nutrients. So, the study of these interactions may allow predicting the behavior of VB12 at cellular membranes and the effects on its activity. Thus, lipid vesicles with lipid composition similar to the majority of eukaryotic cell membranes were used as biomembrane models, and their interactions with VB12 molecules were evaluated. For that, ...
Source: Colloids and Surfaces - June 8, 2020 Category: Biotechnology Authors: Ramalho MJ, Andrade S, Coelho MAN, Loureiro JA, Pereira MC Tags: Colloids Surf B Biointerfaces Source Type: research
A multifunctional polypyrrole/zinc oxide composite coating on biodegradable magnesium alloys for orthopedic implants.
Abstract Magnesium (Mg) and its alloys exhibit great potential in clinical applications owing to the outstanding biological performance and excellent mechanical properties, whereas the quick corrosion rate in the physiological environment has limited their further clinical application. In this work, we designed and developed a multifunctional polypyrrole/zinc oxide (Ppy/ZnO) composite coating by cyclic voltammetry method, aiming to enhance the biocorrosion resistance, biocompatibility and antibacterial property of the Mg alloys. The electrochemical and immersion tests indicated that the corrosion resistance of the...
Source: Colloids and Surfaces - June 8, 2020 Category: Biotechnology Authors: Guo Y, Jia S, Qiao L, Su Y, Gu R, Li G, Lian J Tags: Colloids Surf B Biointerfaces Source Type: research
Docetaxel gold complex nanoflowers: A chemo-biological evaluation for their use as nanotherapeutics.
Abstract Docetaxel (DTX) is an anticancer treatment widely used in the clinic for the treatment of various human malignancies, including Non-Small-Cell Lung Cancer (NSCLC). Its low water solubility and systemic toxicity, however, negatively impact the clinical application of such drug. In order to improve DTX solubility in biological fluids and decrease its adverse effects in patients, the scientific community is currently focusing on developing drug delivery systems where DTX is the payload. In this context, the present study aims at presenting a step forward in the development of platforms based on gold complexe...
Source: Colloids and Surfaces - June 4, 2020 Category: Biotechnology Authors: Haddada MB, Movia D, Prina-Mello A, Spadavecchia J Tags: Colloids Surf B Biointerfaces Source Type: research