Contact-active antibacterial polyethylene foils via atmospheric air plasma induced polymerisation of quaternary ammonium salts.
n W Abstract Polyethylene (PE) foils were modified with potent contact-active antibacterial quaternary ammonium salts (QAS) by an atmospheric air plasma activation step, followed by graft-polymerisation of vinylbenzyltrimethylammonium chloride (VBTAC) monomers. The presented approach uses a cost efficient air plasma activation and subsequent radical polymerisation in highly concentrated aqueous monomer solutions to generate efficient antibacterial materials. The obtained contact-active poly-VBTAC modified PE foils feature a homogeneous and 300 nm thick polymer layer with a high charge density of approximately 1016...
Source: Colloids and Surfaces - November 30, 2019 Category: Biotechnology Authors: Kliewer S, Wicha SG, Bröker A, Naundorf T, Catmadim T, Oellingrath EK, Rohnke M, Streit WR, Vollstedt C, Kipphardt H, Maison W Tags: Colloids Surf B Biointerfaces Source Type: research

CdTe-GSH as luminescent biomarker for labeling the larvicidal action of WSMoL lectin in Aedes aegypti larvae.
, Navarro M Abstract Mosquito-borne arboviruses compromise human health worldwide. Due to resistance to chemical insecticides, natural compounds have been studied to combat mosquitoes. Previous works have demonstrated a larvicidal activity of the water-soluble Moringa oleifera lectin (WSMoL) against Aedes aegypti, suggesting a mechanism of action based on the interaction between lectin and chitin present in the larvae's peritrophic matrix. In this work, it was investigated the WSMoL activity against Aedes aegypti larvae, by using luminescent bioconjugates of WSMoL conjugated to l-glutathione capped CdTe quantum do...
Source: Colloids and Surfaces - November 25, 2019 Category: Biotechnology Authors: Arruda CCL, Freitas DV, Seabra MABL, Xavier-Júnior FH, Figueiredo RCBQ, Napoleão TH, Paiva PMG, Navarro DMAF, Navarro M Tags: Colloids Surf B Biointerfaces Source Type: research

An analytical method to control the surface density and stability of DNA-gold nanoparticles for an optimized biosensor.
ml;rös J Abstract DNA functionalized gold nanoparticles (DNA-AuNPs) have shown great potential for biosensing as they combine the excellent optical properties of gold nanoparticles and the molecular recognition function of DNA. Since the DNA density determines the assay performance and the stability of the conjugate, a precise control of the surface density of DNA-AuNP is crucial for an optimized biosensor. Here we report a simple assay for quantifying multiple unlabeled DNAs on AuNPs. The assay relies on potassium cyanide (KCN) to first dissolve the AuNPs, which then releases surface bound DNA for quantifica...
Source: Colloids and Surfaces - November 23, 2019 Category: Biotechnology Authors: Hwu S, Garzuel M, Forró C, Ihle SJ, Reichmuth AM, Kurdzesau F, Vörös J Tags: Colloids Surf B Biointerfaces Source Type: research

One-pot synthesis of chlorhexidine-templated biodegradable mesoporous organosilica nanoantiseptics.
Abstract Chlorhexidine (CHX) is a widely used antiseptic in various infection control practices. In this work, we have developed biodegradable mesoporous organosilica nanoparticles (MONs) through a one-pot synthesis by employing CHX as a bifunctional agent that not any acts as a cationic template to form the structure of mesopores but also serves as a broad-spectrum antiseptic. The resulting CHX@MONs exhibit a relatively high CHX content and glutathione (GSH)-responsive release of CHX via a matrix-degradation-controlled mechanism, leading to comparable antibacterial effects with CHX on both Escherichia coli and St...
Source: Colloids and Surfaces - November 21, 2019 Category: Biotechnology Authors: He Y, Zhang Y, Sun M, Yang C, Zheng X, Shi C, Chang Z, Wang Z, Chen J, Pei S, Dong WF, Shao D, She J Tags: Colloids Surf B Biointerfaces Source Type: research

How a lipid bilayer membrane responds to an oscillating nanoparticle: Promoted membrane undulation and directional wave propagation.
Abstract Mechanical forces acting on a plasma membrane are of essential importance to cellular functioning via inducing delicate change of the membrane shape with the underlying mechanism yet to be elucidated. Here, we introduce an oscillating nanoparticle (NP) interaction with a lipid bilayer membrane, using the coarse-grained simulation to investigate the dynamic membrane response to constrained mechanical stimulation, which is ubiquitous in biology. Our results demonstrate that, the membrane responds to an oscillating NP by generating nanoscale undulation waves, which immediately propagate through the membrane....
Source: Colloids and Surfaces - November 18, 2019 Category: Biotechnology Authors: Li S, Yan Z, Huang F, Zhang X, Yue T Tags: Colloids Surf B Biointerfaces Source Type: research

Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin.
Abstract Tilmicosin (TMS) is widely applied to treat porcine bacterial respiratory diseases in veterinary medicine. However, oral administration of TMS is greatly limited due to its physicochemical properties, such as poor water solubility, gastric acid sensitivity and bitterness. Therefore, nanostructured lipid carriers (NLCs) were developed as an oral delivery system for TMS by the high shear method combined with ultrasonic techniques in this study. The results showed that TMS-NLCs were approximately spherical with a hydrodynamic diameter of 283.03 nm and a zeta potential of -30.04 mV. TMS was almo...
Source: Colloids and Surfaces - November 17, 2019 Category: Biotechnology Authors: Zhang Q, Yang H, Sahito B, Li X, Peng L, Gao X, Ji H, Wang L, Jiang S, Guo D Tags: Colloids Surf B Biointerfaces Source Type: research

The cooperative interaction of triplex forming oligonucleotides on DNA-triplex formation at electrode surface: Molecular dynamics studies and experimental evidences.
Abstract An extensive study on cooperative interaction of Triplex Forming Oligonucleotides (TFOs) with a double strand DNA, to form a triplex-DNA structure at electrode surface, is here reported. The cooperative effect on triplex structure formation was assumed by the higher binding enthalpy value, calculated for the interaction between the duplex DNA structure and the TFO1 and TFO2 probes (-67.3 KJ/mol), respect the sum of the single duplex-TFO1 and duplex-TFO2 interactions (-47.0 kJ/mol). The formation of triplex-DNA structure was proven by kinetic modelling study performed using the Luzar and Chandler model. Th...
Source: Colloids and Surfaces - November 15, 2019 Category: Biotechnology Authors: Petralia S, Forte G, Zimbone M, Conoci S Tags: Colloids Surf B Biointerfaces Source Type: research

Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF- κB pathway.
Preparation of novel berberine nano-colloids for improving wound healing of diabetic rats by acting Sirt1/NF-κB pathway. Colloids Surf B Biointerfaces. 2019 Nov 14;:110647 Authors: Zhang P, He L, Zhang J, Mei X, Zhang Y, Tian H, Chen Z Abstract In the present work, novel berberine nano-colloids hydrogel (BNH) was prepared for improving wound healing of diabetic rats. Polyvinyl alcohol (PVA), sodium alginate (Alg) were adopted as building blocks to form BNH. Calcium ions was used as crosslink agent to construct BNH. The skin injury model of diabetic rats was successfully established, and the prep...
Source: Colloids and Surfaces - November 14, 2019 Category: Biotechnology Authors: Zhang P, He L, Zhang J, Mei X, Zhang Y, Tian H, Chen Z Tags: Colloids Surf B Biointerfaces Source Type: research

Controlled released of drug from doubled-walled PVA hydrogel/PCL microspheres prepared by single needle electrospraying method.
In this study, we present a one-step simple and rapid single needle electrospraying (SNESy) method that combines PVA hydrogels with another biocompatible polymer polycaprolactone (PCL). A distinct core-shell structure was obtained with the PVA hydrogel core and PCL shell after the system was properly set up. The results revealed that the volume ratio between PVA hydrogel and PCL played an important role in determining the particle size and the formation of a spherical structure. The double-walled structure of the microsphere was confirmed by taking the fluorescent images and conducting the ATR-FTIR method. Furthermore, dox...
Source: Colloids and Surfaces - November 12, 2019 Category: Biotechnology Authors: Zhou X, Hou C, Chang TL, Zhang Q, Liang JF Tags: Colloids Surf B Biointerfaces Source Type: research

Preparation and the hemostatic property study of porous gelatin microspheres both in vitro and in vivo.
Abstract Rapid hemostasis is crucial to saving the lives of traumatic patients in emergency medical treatment. To improve the hemostatic performance of the gelatin microspheres (GMs) in vivo and in vitro, in the study, porous gelatin microspheres (PGMs) were prepared through water-in-oil emulsion method combined with vacuum freeze-drying after cross-linking with glutaraldehyde and prefreeze in liquid nitrogen. Owing to the porous structure and rough surface, the obtained PGMs were effective to induce red blood cells aggregation and promote fibrin generation, which led to improved hemostatic potential than GMs in b...
Source: Colloids and Surfaces - November 12, 2019 Category: Biotechnology Authors: Li L, Du Y, Yin Z, Li L, Peng H, Zheng H, Yang A, Li H, Lv G Tags: Colloids Surf B Biointerfaces Source Type: research

Improved cardioprotective effects of hesperidin solid lipid nanoparticles prepared by supercritical antisolvent technology.
Abstract Doxorubicin (DOX) is commonly used for the treatment of many types of cancers but its cardiotoxicity, owing to free radical formation, limits its clinical use. Hesperidin (HES), a flavanone glycoside, has been shown to exert multiple pharmacological actions including cardioprotective effects. Herein, we aim to formulate HES loaded solid lipid nanoparticles (SLNs) using supercritical antisolvent (SAS) technology to improve the oral delivery of HES. Process parameters were optimized to produce small size (175.3 ± 3.6 nm) HES-SLNs with high encapsulation efficiency (87.6 ± 3.8 %). DSC...
Source: Colloids and Surfaces - November 12, 2019 Category: Biotechnology Authors: Saad S, Ahmad I, Kawish SM, Khan UA, Ahmad FJ, Ali A, Jain GK Tags: Colloids Surf B Biointerfaces Source Type: research

Artificial peptide-controlled protein release of Zn2+-triggered, self-assembled histidine-tagged protein microparticle.
In this study, we employed the well-known hexahistidine (His)-tag recombinant protein technology and a metal-triggerable collagen-mimetic peptide to enhance the binding strength between the protein and metal ion and fine-tuned the protein drug release. His-tagged proteins self-assembled to form microparticles (∼2 μm) upon zinc ion treatment and sustained protein drug release was achieved in physiological saline. The results also indicated that by adjusting the peptide concentration and N- and C-terminal hexahistidine-tags, protein release could be controlled. Moreover, no protein denaturation was observed. We deve...
Source: Colloids and Surfaces - November 12, 2019 Category: Biotechnology Authors: Chen TY, Cheng WJ, Horng JC, Hsu HY Tags: Colloids Surf B Biointerfaces Source Type: research

Temperature and H2O2-operated nano-valves on mesoporous silica nanoparticles for controlled drug release and kinetics.
Abstract Temperature and H2O2 dual-responsive nanoparticles were fabricated from ferrocene modified mesoporous silica (MSN-Fc) and β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star-shaped polymer due to the host-guest interactions for controlled drug release. The formation and structure of β-CD-PNIPAM@MSN-Fc composite nanoparticles was confirmed by FTIR, TGA, TEM and N2 adsorption-desorption isotherms. The size of nanoparticles was about 100-150 nm with well-ordered mesoporous structure and PNIPAM chains coating on the surface as outer shell. The channels of MSNs and hydrophobic c...
Source: Colloids and Surfaces - November 12, 2019 Category: Biotechnology Authors: Guo F, Li G, Zhou H, Ma S, Guo L, Liu X Tags: Colloids Surf B Biointerfaces Source Type: research

Engineering of antibacterial/recyclable difunctional nanoparticles via synergism of quaternary ammonia salt site and N-halamine sites on magnetic surface.
Abstract A biocidal composite unit with improved synergism, using one cationic quaternary ammonia salt (QAS) site to attract electronegative bacteria to three highly biocidal N-halamine sites, was designed for the first time and attached onto surface of magnetic silica coated Fe3O4 nanoparticles (silica@Fe3O4NPs) for superior biocidability, large killing area, and easy recyclability. Briefly, a compound containing one imide and two amide NH bonds, 2-(2,5-dioxoimidazolidin-4-yl)-N-(4-hydroxyphenyl)acetamide (DHPA), was prepared by amidation of hydantoin acetic acid with p-aminophenol. A biocidal precursor of one QA...
Source: Colloids and Surfaces - November 12, 2019 Category: Biotechnology Authors: Chen Y, Feng C, Zhang Q, Luo M, Xu J, Han Q Tags: Colloids Surf B Biointerfaces Source Type: research

Cardio protective role of wogonin loaded nanoparticle against isoproterenol induced myocardial infarction by moderating oxidative stress and inflammation.
Abstract Wogonin, one of the main active ingredients of Scutellaria radix, is a kind of flavonoid compound. In the present study, we report that wogonin nanoparticles (Wog np) protect Isoproterenol (ISO) induced Myocardial Infarction (MI) rats. Nanoparticles of sizes less than 200 nm with spherical shape were prepared using Polylactic-co-glycolic acid (PLGA) and Polyvinyl alcohol (PVA) respectively as polymer and stabilizer. Male Wistar rats were divided into 4 groups. Group 1 as a control group administered with physiological saline solution with 0.5 % carboxymethylcellulose (1 mL/day). Group 2 served as toxi...
Source: Colloids and Surfaces - November 10, 2019 Category: Biotechnology Authors: Bei W, Jing L, Chen N Tags: Colloids Surf B Biointerfaces Source Type: research

Differential properties and effects of fluorescent carbon nanoparticles towards intestinal theranostics.
Casaos A, Benito AM, Maser WK Abstract Given the potential applications of fluorescent carbon nanoparticles in biomedicine, the relationship between their chemical structure, optical properties and biocompatibility has to be investigated in detail. In this work, different types of fluorescent carbon nanoparticles are synthesized by acid treatment, sonochemical treatment, electrochemical cleavage and polycondensation. The particle size ranges from 1 to 6 nm, depending on the synthesis method. Nanoparticles that were prepared by acid or sonochemical treatments from graphite keep a crystalline core and can be class...
Source: Colloids and Surfaces - November 9, 2019 Category: Biotechnology Authors: Vallan L, Hernández-Ferrer J, Grasa L, González-Domínguez JM, Martínez MT, Ballesteros B, Urriolabeitia EP, Ansón-Casaos A, Benito AM, Maser WK Tags: Colloids Surf B Biointerfaces Source Type: research

Lidocaine tripotassium phosphate complex laden microemulsion for prolonged local anaesthesia: In vitro and in vivo studies.
Abstract Lidocaine is widely used as a local anaesthetic in the clinical practice to manage pre- and post-operative pain, skin burns, etc. However, the short duration of action (
Source: Colloids and Surfaces - November 9, 2019 Category: Biotechnology Authors: Maulvi FA, Pillai LV, Patel KP, Desai AR, Shukla MR, Desai DT, Patel HP, Ranch KM, Shah SA, Shah DO Tags: Colloids Surf B Biointerfaces Source Type: research

Activatable MRI-monitoring gene delivery for the theranostic of renal carcinoma.
In this study, we constructed a PEG-MnO2-OPN siRNA nanocomplex via a modular streptavidin bridge for the theranostic treatment of renal carcinoma in vitro and in vivo. This strategy of utilizing PEG-MnO2 nanosheets for OPN siRNA delivery showed effective tumor growth inhibition of 786-O tumor-bearing mice, and such a process could be monitored by the activated T1-weight MRI, illustrating the promising potential of PEG-MnO2 nanosheets for the fabrication of an MRI-based theranostic system. PMID: 31734089 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - November 8, 2019 Category: Biotechnology Authors: Shi M, Wang S, Zheng S, Hou P, Dong L, He M, Wu C, Zhang X, Zuo F, Xu K, Li J Tags: Colloids Surf B Biointerfaces Source Type: research

Controlling the rheological properties of W1/O/W2 multiple emulsions using osmotic swelling: Impact of WPI-pectin gelation in the internal and external aqueous phases.
Abstract The purpose of this study was to create W1/O/W2 Multiple Emulsions by controlled osmotic swelling, and gelation of whey protein isolate (WPI) and high methoxy pectin (HMP) microspheres in internal and external acidic aqueous phases. Three different kinds of W1/O/W2 multiple emulsions (ME) were prepared, with 8 wt.% Polyglycerol polyricinoleate (PGPR) in their oil phases, with WPI and HMP in internal and external aqueous phases (250 mM NaCl, pH 3.5): (i) ME1: The inner aqueous phase (W1) contained 40% buffer solution, while W2 consisted of 10% WPI and 2% HMP; (ii) ME2: W1 contained 10% WPI, with 2% HMP...
Source: Colloids and Surfaces - November 6, 2019 Category: Biotechnology Authors: Iqbal S, Chen XD, Kirk TV, Huang H Tags: Colloids Surf B Biointerfaces Source Type: research

Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria.
Abstract Biofilm formed by several pathogenic bacteria results in the development of resistance against antimicrobial compounds. The polymeric materials present in the biofilm architecture hinder the entry of antimicrobial compounds through the surface of bacterial cells which are embedded as well as enclosed beneath the biofilm matrix. Recent and past studies explored the alternative approaches to inhibit the formation of biofilm by different agents isolated from plants, animals, and microbes. Among these agents, chitosan and its derivatives have got more attention due to their properties such as biodegradability...
Source: Colloids and Surfaces - November 5, 2019 Category: Biotechnology Authors: Khan F, Pham DTN, Oloketuyi SF, Manivasagan P, Oh J, Kim YM Tags: Colloids Surf B Biointerfaces Source Type: research

Mimicking biological process to detect alkaline phosphatase activity using the vitamin B6 cofactor conjugated bovine serum albumin capped CdS quantum dots.
Abstract This manuscript presents a novel bioanalytical approach for the selective ratiometric fluorescent sensing of enzymatic activity of the alkaline phosphatase (ALP) in the biological samples. The probe was designed by conjugating the pyridoxal 5'-phosphate (PLP) over the surface of bovine serum albumin (BSA) stabilized CdS quantum dots (QDs) through the interaction of free amine present in BSA with the aldehyde group of PLP. The conjugation of PLP quenched the emission of QDs. Upon addition of the ALP, the emission of QDs was restored due to the dephosphorylation and the conversion of the functionalized PLP ...
Source: Colloids and Surfaces - November 4, 2019 Category: Biotechnology Authors: Upadhyay Y, Bothra S, Kumar R, Kumar Sk A, Sahoo SK Tags: Colloids Surf B Biointerfaces Source Type: research

Significant bile salt induced perturbation of niosome membrane: A molecular level interaction study using 1-Naphthol fluorescence.
This study demonstrates that significant perturbation of tween20:cholesterol(1:1) niosome membrane takes place even at premicellar concentration of bile salts. Here, 1-naphthol (1-NpOH), a known and sensitive excited state proton transfer (ESPT) probe, was used to understand the nature of perturbation of the membrane in an unbuffered medium. The significant decrease in 1-NpOH fluorescence intensity in niosome-bile salt mixed system at both lower (10 °C) and higher (50 °C) temperatures indicates the bile salts [sodium cholate (NaC) and sodium deoxycholate (NaDC)] induce perturbation of niosome membranes. Variati...
Source: Colloids and Surfaces - November 2, 2019 Category: Biotechnology Authors: Mishra J, Mishra AK Tags: Colloids Surf B Biointerfaces Source Type: research

Superhydrophobic copper in biological liquids: Antibacterial activity and microbiologically induced or inhibited corrosion.
Abstract The bactericidal activity of copper and copper alloys is well appreciated and was already exploited in medical practice in 19th century. However, despite of being an essential nutrient required by organisms to perform life functions, excess copper is extremely toxic and detrimental to health. Recent studies have shown that superhydrophobic surfaces have a significant antibacterial potential for reduction of nosocomial infections. At the same time, the prolonged contact with biological liquids may cause a degradation of the superhydrophobic copper surface and corrosion with increasing egress of toxic coppe...
Source: Colloids and Surfaces - November 2, 2019 Category: Biotechnology Authors: Emelyanenko AM, Pytskii IS, Kaminsky VV, Chulkova EV, Domantovsky AG, Emelyanenko KA, Sobolev VD, Aleshkin AV, Boinovich LB Tags: Colloids Surf B Biointerfaces Source Type: research

Yttrium vanadates based ratiometric fluorescence probe for alkaline phosphatase activity sensing.
Abstract Alkaline phosphatase (ALP) is an important biomarker for diagnosis, and the abnormal level of serum ALP is closely related to a variety of diseases. In present work, a ratiometric fluorescence probe based on hybrid nanoparticles CDs@YVO4: Dy3+ nanoparticle is introduced for alkaline phosphatase (ALP) activity determination. The CDs@YVO4: Dy3+ probe is constructed by the carbon dots (CDs) and YVO4: Dy3+ through a simple mixing method, in which the blue emission of CDs at 405 nm acts as the calibrated signal, the green emission of YVO4: Dy3+ at 574 nm decreased with the increasing targets ALP, and used ...
Source: Colloids and Surfaces - November 2, 2019 Category: Biotechnology Authors: Xiao W, Liu F, Yan GP, Shi WG, Peng KL, Yang XQ, Li XJ, Yu HC, Shi ZY, Zeng HH Tags: Colloids Surf B Biointerfaces Source Type: research

Biomedical application of graphene: From drug delivery, tumor therapy, to theranostics.
Abstract The rise of graphene has driven great revolution in various fields, e. g. electronics, device, energy, etc., owing to the well-researched understanding of its physical and chemical properties. In the very recent decade, scientists have poured significant efforts to explore the biological functions of graphene and expand its biomedical applications, including drug delivery, tumor therapy, and theranostics. Encouraged by the inspiring research results and promising contributions of graphene to biomedicine field, herein, we systematically summarize the recent advance of graphene for biomedical application. I...
Source: Colloids and Surfaces - November 2, 2019 Category: Biotechnology Authors: Song S, Shen H, Wang Y, Chu X, Xie J, Zhou N, Shen J Tags: Colloids Surf B Biointerfaces Source Type: research

Dual function of interleukin-23 Aptamer to suppress brain inflammation via attachment to macrophage stimulating 1 kinase and interleukin-23.
This study showed that IL-23 Aptamer could reduce the clinical development of brain inflammation induced by Parathion, as an important organophosphate toxin. Both immunostaining and H&E staining indicated that the total inflammatory infiltration foci were remarkably decreased in IL-23 Aptamer-treated mice. Moreover, this study showed that IL-23 Aptamer reduced both absolute and relative numbers of MST1+CD4 + Th1 cells and IL-23-producing cells. Analysis of the Hippo signaling genes showed a sharp decrease of MST1 kinase compared with other genes (P 
Source: Colloids and Surfaces - November 2, 2019 Category: Biotechnology Authors: Shahdadi Sardou H, Jebali A, Iman M Tags: Colloids Surf B Biointerfaces Source Type: research

A 1,8-naphthalimide-[12]aneN3 derivative for efficient Cu2+ recognition, lysosome staining and siRNA delivery.
Abstract Development of multifunctional compounds as both fluorescence probes and non-viral vectors is still difficult till date. It is necessary to overcome many hurdles such as the balance of hydrophilic and hydrophobic moieties, binding affinity between multifunctional compound and targeting substrate, the cytotoxicity of multifunctional compound, and so on. In this work, the performances of compound 1 on Cu2+ recognition, lysosome staining and siRNA (small interfering RNA) delivery were investigated. It was found that compound 1 exhibited high selectivity and sensitivity toward Cu2+ in aqueous solutions. The f...
Source: Colloids and Surfaces - November 1, 2019 Category: Biotechnology Authors: Gao YG, Dang K, Zhang WJ, Liu FL, Patil S, Qadir A, Ding AX, Qian AR Tags: Colloids Surf B Biointerfaces Source Type: research

Kinetic study of A β(1-42) amyloidosis in the presence of ganglioside-containing vesicles.
Kinetic study of Aβ(1-42) amyloidosis in the presence of ganglioside-containing vesicles. Colloids Surf B Biointerfaces. 2019 Oct 31;185:110615 Authors: Dai Y, Zhang M, Shi X, Wang K, Gao G, Shen L, Sun T Abstract Alzheimer's disease (AD) is characterized by the amyloid-beta peptide (Aβ) misfolding to form aberrant amyloid aggregates in the brain. Although recent evidence implicates that amyloid deposition in vivo is highly related to biomembranes, how the characteristic lipid components of neuronal membranes mediate this process remains to be fully elucidated. Herein, we established vesicle...
Source: Colloids and Surfaces - October 31, 2019 Category: Biotechnology Authors: Dai Y, Zhang M, Shi X, Wang K, Gao G, Shen L, Sun T Tags: Colloids Surf B Biointerfaces Source Type: research

Corrigendum to "Evaluation of the biocompatibility and skin hydration potential of vitamin E-loaded lipid nanosystems formulations: In vitro and human in vivo studies" [Colloid Surfaces B: Biointerfaces 179 (2019) 242-249].
Corrigendum to "Evaluation of the biocompatibility and skin hydration potential of vitamin E-loaded lipid nanosystems formulations: In vitro and human in vivo studies" [Colloid Surfaces B: Biointerfaces 179 (2019) 242-249]. Colloids Surf B Biointerfaces. 2019 Oct 30;185:110593 Authors: Vaz S, Silva R, Amaral MH, Martins E, Sousa Lobo JM, Silva AC PMID: 31677413 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - October 30, 2019 Category: Biotechnology Authors: Vaz S, Silva R, Amaral MH, Martins E, Sousa Lobo JM, Silva AC Tags: Colloids Surf B Biointerfaces Source Type: research

Drug-templated mesoporous silica nanocontainers with extra high payload and controlled release rate.
Abstract The possibility of one-step creating of pH-sensitive mesostructured silica-based nanocontainers with exceptionally high payload using associates of two antiseptics (including hydrolyzable one) as templates is demonstrated. The effects of the template nature and the conditions of the sol-gel process on the porous structure of silica nanocontainers are studied and discussed. The kinetics of the templating drug release from such containers is studied and some features of this process are analyzed. It is shown that the drug release rate can be tuned by varying the medium pH. The bactericidal activity of two e...
Source: Colloids and Surfaces - October 22, 2019 Category: Biotechnology Authors: Dement'eva OV, Naumova KA, Zhigletsova SK, Klykova MV, Somov AN, Dunaytsev IA, Senchikhin IN, Volkov VV, Rudoy VM Tags: Colloids Surf B Biointerfaces Source Type: research

Self-healing PEG-poly(aspartic acid) hydrogel with rapid shape recovery and drug release.
Abstract Self-healing hydrogels were prepared from hydrazide functionalized poly(aspartic acid) (PAsp). The polymer succinimide (PSI) was reacted with hydrazine and ethanolamine successively to obtain water soluble poly(aspartic acid) derivatives with hydrazide functional groups (PAEH). The hydrogel was prepared by cross-linking PAEH with poly(ethylene glycol) dialdehyde (PEG DA) under mild conditions without addition of catalyst. The rheological property and the self-healing property of the hydrogels were investigated intensively. The in vitro toxicity experiment showed the hydrogels have good bio-compatibility a...
Source: Colloids and Surfaces - October 22, 2019 Category: Biotechnology Authors: An H, Zhu L, Shen J, Li W, Wang Y, Qin J Tags: Colloids Surf B Biointerfaces Source Type: research

Magnetically-oriented type I collagen-SiO2@Fe3O4 rods composite hydrogels tuning skin cell growth.
Abstract Conferring orientational order to biological hydrogels constitutes a fruitful strategy for the guided growth of cells. The ability of anisotropic magnetic particles to align along an external magnetic field appears as a particularly, yet poorly explored, strategy to achieve such an orientation in 3D. For this purpose, silica rods coated with magnetite nanoparticles were prepared. When dispersed in a collagen type I solutions, they could be aligned along the magnetic field generated by two plate magnets within five minutes, such an alignment being preserved during hydrogel formation. Both magnetic and rheo...
Source: Colloids and Surfaces - October 20, 2019 Category: Biotechnology Authors: Shi Y, Li Y, Coradin T Tags: Colloids Surf B Biointerfaces Source Type: research

Effect of a dirhamnolipid biosurfactant on the structure and phase behaviour of dimyristoylphosphatidylserine model membranes.
Abstract Rhamnolipids are bacterial biosurfactants containing one or two rhamnose rings and a hydrophobic hydrocarbon portion. These compounds are mainly isolated from Pseudomonas spp culture media, and have been shown to present outstanding biological activities. A number of experimental works have shown that the interaction of rhamnolipids with target membranes could play a role in these actions. Therefore the study of the interaction of purified rhamnolipids with the various phospholipid components of biological membranes is of great interest. This paper shows the phase behaviour of mixtures of 1,2-dimyristolyl...
Source: Colloids and Surfaces - October 19, 2019 Category: Biotechnology Authors: Oliva A, Teruel JA, Aranda FJ, Ortiz A Tags: Colloids Surf B Biointerfaces Source Type: research

Injected laquinimod D- α-tocopheryl polyethylene glycol-1000 succinate polymeric micelles for the treatment of inflammatory bowel disease.
Injected laquinimod D-α-tocopheryl polyethylene glycol-1000 succinate polymeric micelles for the treatment of inflammatory bowel disease. Colloids Surf B Biointerfaces. 2019 Oct 19;185:110575 Authors: Wang L, Xue P, Tong M, Chen R, Yang W, ZhuGe D, Yuan J, Yao Q, Zhao Y, Xu H Abstract Inflammatory bowel diseases (IBDs) are chronic relapsing disorders of the gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial injury. Laquinimod (LAQ), a poorly water-soluble compound, was proved to be effective for colitis remission at low dose of 0.5 mg/kg in patie...
Source: Colloids and Surfaces - October 19, 2019 Category: Biotechnology Authors: Wang L, Xue P, Tong M, Chen R, Yang W, ZhuGe D, Yuan J, Yao Q, Zhao Y, Xu H Tags: Colloids Surf B Biointerfaces Source Type: research

PEGylated MoS2 quantum dots for traceable and pH-responsive chemotherapeutic drug delivery.
Abstract Since low pH value is widely observed in most of solid tumors, pH-responsive drug delivery system (DDS) can provide a general strategy for tumor-targeting therapy. In this work, a traceable and pH-responsive DDS (MoS2-PEG-DOX) based on MoS2 quantum dots (MoS2 QDs) is successfully developed by covalently grafting MoS2 QDs with diamine-terminated oligomeric polyethylene glycol (PEG) and then loading with a fluorescent antineoplastic anthracycline drug, doxorubicin (DOX). The functionalization of MoS2 QDs with PEG imparts the nanocomposite with strong blue photoluminescence, low cytotoxicity, and excellent p...
Source: Colloids and Surfaces - October 16, 2019 Category: Biotechnology Authors: Liu L, Jiang H, Dong J, Zhang W, Dang G, Yang M, Li Y, Chen H, Ji H, Dong L Tags: Colloids Surf B Biointerfaces Source Type: research

Covalent grafting of titanium with a cathelicidin peptide produces an osteoblast compatible surface with antistaphylococcal activity.
In this study, the widely used biomaterial titanium was functionalized with BMAP27(1-18), an α-helical cathelicidin antimicrobial peptide that retains potent staphylocidal activity when immobilized on agarose beads. A derivative bearing a short spacer with a free thiol at the N-terminus was coupled to silanized titanium disks via thiol-maleimide chemistry. Tethering was successful, as assessed by Contact angle, Quartz Crystal Microbalance with Dissipation monitoring (QCM-D), and X-ray Photoelectron Spectroscopy (XPS), with an average surface mass density of 456 ng/cm2 and a layer thickness of 3 nm. The functional...
Source: Colloids and Surfaces - October 16, 2019 Category: Biotechnology Authors: Boix-Lemonche G, Guillem-Marti J, D'Este F, Manero JM, Skerlavaj B Tags: Colloids Surf B Biointerfaces Source Type: research

Enzyme responsive titanium substrates with antibacterial property and osteo/angio-genic differentiation potentials.
Abstract After implantation into a host, titanium (Ti) orthopaedic materials are facing two major clinical challenges: bacterial infection and aseptic loosening, which directly determine the long-term survival of the implant. To endow Ti implant with self-defensive antibacterial properties and desirable osteo/angio-genic differentiation potentials, hyaluronic acid (HA)-gentamicin (Gen) conjugates (HA-Gen) and chitosan (Chi) polyelectrolyte multilayers were constructed on deferoxamine (DFO) loaded titania nanotubes (TNT) substrates via layer-by-layer (LBL) assembly technique, termed as TNT/DFO/HA-Gen. The HA-Gen co...
Source: Colloids and Surfaces - October 15, 2019 Category: Biotechnology Authors: Yu Y, Ran Q, Shen X, Zheng H, Cai K Tags: Colloids Surf B Biointerfaces Source Type: research

Fe3O4 composited with MoS2 blocks horizontal gene transfer.
This study highlights the diverse biological properties of nano-materials and provides clues for nano-scientists to develop environmentally friendly materials. PMID: 31629970 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - October 11, 2019 Category: Biotechnology Authors: Wang H, Qi H, Gong S, Huang Z, Meng C, Zhang Y, Chen X, Jiao X Tags: Colloids Surf B Biointerfaces Source Type: research

Investigating the synergetic dispersing effect of hydrolyzed biomacromolecule Cellulase and SDS on CuPc pigment.
This study demonstrated that there were strong interactions between hydrolyzed cellulase and SDS to result in synergistic dispersing effect on CuPc for better stability. PMID: 31627101 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - October 10, 2019 Category: Biotechnology Authors: Zhao Y, Wang R, Fang K, Tan Y, Chen S, Guan Y, Hao L Tags: Colloids Surf B Biointerfaces Source Type: research

Incorporation of bioflavonoids from Bidens tripartite into micelles of non-ionic surfactants - experimental and theoretical studies.
Abstract Classical extraction methods used for an isolation of active substances from the plant material are expensive, complicated and often environmentally unfriendly. The ultrasonic assistance micelle-mediated extraction method (UAMME) seems to be an interesting alternative. The aim of this work was to compare an efficiency of water solutions of three non-ionic surfactants: C9-11 Pareth-5, PPG-6 Steareth-7 and PPG-4 Laureth-5 in UAMME of Bidens tripartita. Subsequently, the obtained extracts were separated into two immiscible phases, a polyphenols rich surfactants phase and an aqueous phase by its heating above...
Source: Colloids and Surfaces - October 6, 2019 Category: Biotechnology Authors: Śliwa P, Śliwa K, Sikora E, Ogonowski J, Oszmiański J, Nowicka P Tags: Colloids Surf B Biointerfaces Source Type: research

Oral delivery of paclitaxel by polymeric micelles: A comparison of different block length on uptake, permeability and oral bioavailability.
In conclusion, the knowledge gained in this study enables rational design of polymeric micelles to overcome the current challenges of oral drug delivery and it also provides a basis for future clinical translation of the technology. PMID: 31627103 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - October 6, 2019 Category: Biotechnology Authors: Sze LP, Li HY, Lai KLA, Chow SF, Li Q, KennethTo KW, Lam TNT, Lee WYT Tags: Colloids Surf B Biointerfaces Source Type: research

Bottom-up synthesis of nitrogen and oxygen co-decorated carbon quantum dots with enhanced DNA plasmid expression.
Abstract In this paper, a bottom-up hydrothermal route is reported for the synthesis of oxygen and nitrogen co-decorated carbon quantum dots (CQDs) using ammonium hydrogen citrate (AHC) as a single precursor. DLS data approved the formation of 4.0 nm (average size) CQDs. XRD pattern shows the interlayer spacing (002) of 3.5 Å for CQDs, which is exactly the same as that of crystalline graphite. XPS and FTIR spectra verified the formation of oxygen and nitrogen functional groups on the CQDs surface. Co-decorated carboxyl, hydroxyl and amine groups on the CQDs surfaces make them as promising polyelectrolyte...
Source: Colloids and Surfaces - October 5, 2019 Category: Biotechnology Authors: Yadegari A, Khezri J, Esfandiari S, Mahdavi H, Karkhane AA, Rahighi R, Heidarimoghadam R, Tayebi L, Hashemi E, Farmany A Tags: Colloids Surf B Biointerfaces Source Type: research

Multifunctional MoS2 nanosheets with Au NPs grown in situ for synergistic chemo-photothermal therapy.
Abstract The treatment of cancer has always been a worldwide problem. The combination of chemotherapy and other therapies would be a promising therapy strategy. Photothermal therapy (PTT) does not cause serious side effects and has dual control of time and space, which was considered to be a good method for combination with chemotherapy. Here, we modified multifunctional nanosheets based on in-situ gold nanoparticles (Au NPs) grown molybdenum disulfide (MoS2) to combine their excellent photothermal conversion and drug loading capabilities. More importantly, the target peptide cRGD modified nanosheets have good sel...
Source: Colloids and Surfaces - October 4, 2019 Category: Biotechnology Authors: Xu M, Zhang K, Liu Y, Wang J, Wang K, Zhang Y Tags: Colloids Surf B Biointerfaces Source Type: research

Interaction of cysteine and its derivatives with monolayers of dipalmitoylphosphatidylcholine.
uy FG Abstract Molecular interactions between l-cysteine (Cys) and its ester derivatives (Cysx); l-cysteine ethyl ester (CE), l-cysteine methyl ester (CM) and N-acetyl l-cysteine (NAC) with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) monolayers were investigated using Langmuir film balance technique. The effect of charge on monolayers made of cysteine and three ester derivatives with DPPC was investigated by working with un-buffered and buffered subphases. Also, the effects of cysteine derivatives interaction with DPPC monolayers were studied measuring the change in the surface tension upon aminoacid inject...
Source: Colloids and Surfaces - October 4, 2019 Category: Biotechnology Authors: Arias JM, Díaz SB, Ben Altabef A, Dupuy FG Tags: Colloids Surf B Biointerfaces Source Type: research

Nanoparticles at biointerfaces: Antibacterial activity and nanotoxicology.
Abstract Development of a biomaterial that is resistant to the adhesion and consequential proliferation of bacteria, represents a significant challenge in terms of application of such materials in various aspects of health care. Over recent years a large number of synthetic methods have appeared with the overall goal of the prevention of bacterial adhesion to surfaces. In contrast to these artificial techniques, living organisms over millions of years have developed different systems to prevent the colonization of microorganisms. Recently, these natural approaches, which are based on surface nanotopography, have b...
Source: Colloids and Surfaces - October 4, 2019 Category: Biotechnology Authors: Kheiri S, Liu X, Thompson M Tags: Colloids Surf B Biointerfaces Source Type: research

Self-gelling electroactive hydrogels based on chitosan-aniline oligomers/agarose for neural tissue engineering with on-demand drug release.
Abstract Designing biomimetic scaffolds is an intellectual challenge of the realm of regenerative medicine and tissue engineering. An electroactive substrate should meet multidisciplinary mimicking the mechanical, electrical, and electrochemical properties of neural tissues. Hydrogels have been known platforms to regulate neural interface modulus, but the lack of conductivity always hampered their applications; hence, developing conductive hydrogels with on-demand drug release has become a concern of tissue engineering. In this work, electroactive hydrogels based on chitosan-aniline oligomer and agarose with self-...
Source: Colloids and Surfaces - October 4, 2019 Category: Biotechnology Authors: Bagheri B, Zarrintaj P, Surwase SS, Baheiraei N, Saeb MR, Mozafari M, Kim YC, Park OO Tags: Colloids Surf B Biointerfaces Source Type: research

Nucleic acid carrier composed of a branched fatty acid lysine conjugate-Interaction studies with blood components.
ouml;lk C Abstract For the development of gene therapeutics for systemic administration several hurdles have to be overcome. In this article we screen the branched fatty acid lysine conjugate T14diLys, a newly designed cationic lipid for lipofection, regarding this problem. The structure and particle size of lipoplexes, prepared with lipid formulations which are based on these lipid as nucleic acid complexing agent, are investigated in absence and presence of serum. Nuclease digestion assays were performed to evaluate the protective characteristics of the lipid formulation for the complexed nucleic acid. Furthermo...
Source: Colloids and Surfaces - October 3, 2019 Category: Biotechnology Authors: Giselbrecht J, Wiedemann S, Reddy Pinnapireddy S, Goergen N, Loppnow H, Sedding D, Erdmann F, Bakowsky U, Hause G, Lúcio M, Langner A, Wölk C Tags: Colloids Surf B Biointerfaces Source Type: research

Evidence of oxygen defects mediated enhanced photocatalytic and antibacterial performance of ZnO nanorods.
Abstract Defect engineered one-dimensional (1D) ZnO nanostructures have found great interest in diverse fields, including water detoxification and environmental remediation. In this article, we report a facile, low-temperature hydrothermal synthesis of defect enriched ZnO nanorods at different pH conditions. The dimension of all the synthesized ZnO nanostructures was restricted to 1D with changes only in their aspect ratios, unlike previous reports where change in morphology accompanies the effect of pH. With an increment in the pH value of the reaction mixture, oxygen defect concentration was controlled and confi...
Source: Colloids and Surfaces - October 3, 2019 Category: Biotechnology Authors: Singh J, Juneja S, Palsaniya S, Manna AK, Soni RK, Bhattacharya J Tags: Colloids Surf B Biointerfaces Source Type: research

CD47-targeted bismuth selenide nanoparticles actualize improved photothermal therapy by increasing macrophage phagocytosis of cancer cells.
In conclusion, Ab-PEG-Bi2Se3 may serve as an efficient PTT platform in combination with macrophage-mediated immunotherapy to improve antitumor efficacy. PMID: 31606701 [PubMed - as supplied by publisher] (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - October 3, 2019 Category: Biotechnology Authors: Guo Z, Liu Y, Zhou H, Zheng K, Wang D, Jia M, Xu P, Ma K, Cui C, Wang L Tags: Colloids Surf B Biointerfaces Source Type: research

Griseofulvin solvate solid dispersions with synergistic effect against fungal biofilms.
Abstract Fungal biofilms are invariably recalcitrant to antifungal drugs and thus can cause recurrent serious infections. The aim of this work was to prepare highly effective form of the antifungal drug griseofulvin using the chloroform solvate embedded into different polymeric matrices. Based on their solid solubility, solvated (chloroform) and non-solvated (methanol and acetone) solid dispersions were prepared using different materials: silica, microcrystalline cellulose, polyvinylpyrrolidone and hydroxypropyl methylcellulose acetate succinate (HPMCAS) by which HPMCAS dispersions showed the highest solubility of...
Source: Colloids and Surfaces - October 3, 2019 Category: Biotechnology Authors: Al-Obaidi H, Kowalczyk RM, Kalgudi R, Zariwala MG Tags: Colloids Surf B Biointerfaces Source Type: research