Machine learning-based exosome profiling of multi-receptor SERS sensors for differentiating adenocarcinoma in situ from early-stage invasive adenocarcinoma
Colloids Surf B Biointerfaces. 2024 Feb 24;236:113824. doi: 10.1016/j.colsurfb.2024.113824. Online ahead of print.ABSTRACTExosomes, extracellular vesicles released by cells, hold potential as diagnostic markers for the early detection of lung cancer. Despite their clinical promise, current technologies lack rapid and effective means to discriminate between exosomes derived from adenocarcinoma in situ (AIS) and early-stage invasive adenocarcinoma (IAC). This challenge arises from the intrinsic structural heterogeneity of exosomes, necessitating the development of advanced methodologies for precise differentiation. Here, we ...
Source: Colloids and Surfaces - March 3, 2024 Category: Biotechnology Authors: Dechan Lu Bohan Zhang Zhikun Shangguan Yudong Lu Jingbo Chen Zufang Huang Source Type: research

Transition from active motion to anomalous diffusion for Bacillus subtilis confined in hydrogel matrices
Colloids Surf B Biointerfaces. 2024 Feb 15;236:113797. doi: 10.1016/j.colsurfb.2024.113797. Online ahead of print.ABSTRACTWe investigate the motility of B. subtilis under different degrees of confinement induced by transparent porous hydrogels. The dynamical behavior of the bacteria at short times is linked to characteristic parameters describing the hydrogel porosity. Mean squared displacements (MSDs) reveal that the run-and-tumble dynamics of unconfined B. subtilis progressively turns into sub-diffusive motion with increasing confinement. Correspondingly, the median instantaneous velocity of bacteria decreases and become...
Source: Colloids and Surfaces - March 3, 2024 Category: Biotechnology Authors: Gavino Bassu Marco Laurati Emiliano Fratini Source Type: research

Machine learning-based exosome profiling of multi-receptor SERS sensors for differentiating adenocarcinoma in situ from early-stage invasive adenocarcinoma
Colloids Surf B Biointerfaces. 2024 Feb 24;236:113824. doi: 10.1016/j.colsurfb.2024.113824. Online ahead of print.ABSTRACTExosomes, extracellular vesicles released by cells, hold potential as diagnostic markers for the early detection of lung cancer. Despite their clinical promise, current technologies lack rapid and effective means to discriminate between exosomes derived from adenocarcinoma in situ (AIS) and early-stage invasive adenocarcinoma (IAC). This challenge arises from the intrinsic structural heterogeneity of exosomes, necessitating the development of advanced methodologies for precise differentiation. Here, we ...
Source: Colloids and Surfaces - March 3, 2024 Category: Biotechnology Authors: Dechan Lu Bohan Zhang Zhikun Shangguan Yudong Lu Jingbo Chen Zufang Huang Source Type: research

Dual functionality of diacylglycerols in water-in-oil emulsion gel systems
Colloids Surf B Biointerfaces. 2024 Feb 21;236:113810. doi: 10.1016/j.colsurfb.2024.113810. Online ahead of print.ABSTRACTDistearin (DS) can be used as an emulsifier, due to its surface activity derived from the amphiphilic nature of the molecule, moreover, it can also crystallize and form a 3D crystal network that can induce oil gelation. The current research aimed to examine the ability to combine both emulsifying and oil gelation properties to structure and stabilize water-in-oil emulsion gel system. Different water contents and DS concentrations produce emulsion gels with different textural attributes while incorporati...
Source: Colloids and Surfaces - March 2, 2024 Category: Biotechnology Authors: Karin Wagner Maya Davidovich-Pinhas Source Type: research

Dialysis-functionalized microfluidic platform for in situ formation of purified liposomes
In this study, we developed a dialysis-functionalized microfluidic platform (DFMP) for in situ formation of purified drug-loaded liposomes. The device was successfully fabricated by using a high-resolution projection micro stereolithography (PμSL) 3D printer. The integrated DFMP consists of a microfluidic mixing unit, a microfluidic dialysis unit, and a dialysis membrane, enabling the liposome preparation and purification in one device. The purified ICG-loaded liposomes prepared by DFMP had a smaller size (264.01±5.34 nm to 173.93±10.71 nm) and a higher encapsulation efficiency (EE) (43.53±0.07% to 46.07±0.67%). In vi...
Source: Colloids and Surfaces - March 2, 2024 Category: Biotechnology Authors: Han Shan Qi Sun Yang Xie Xiangdong Liu Xiang Chen Shuang Zhao Zeyu Chen Source Type: research

Effective pickering emulsifiers based on submicron carboxymethyl cellulose/chitosan polymer particles
In this study, cross-linked carboxymethyl cellulose/chitosan submicron particles were employed to facilitate the stabilization of Pickering emulsion. The polymer particles were prepared using the polyelectrolyte self-assembly method in conjunction with isocyanide based multicomponent reactions and the characteristics were obtained using: nuclear magnetic resonance, Fourier-transform infrared spectroscopy and dynamic light scattering. Atomic force microscopy revealed the heterogeneous structure of the resulting submicron particles with domains of 20-30 nm in size. The average diameter was found to be in the range of 229-378...
Source: Colloids and Surfaces - March 2, 2024 Category: Biotechnology Authors: Emmanuel O Mensah Rita S Alqubelat Yaroslava A Menzorova Artem S Minin Maxim A Mironov Source Type: research

Thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of EGF to inhibit cervical cancer recurrence
Colloids Surf B Biointerfaces. 2024 Feb 16;236:113795. doi: 10.1016/j.colsurfb.2024.113795. Online ahead of print.ABSTRACTOverexpression of epidermal growth factor receptor (EGFR) in cancer is a key cause of recurrence of cervical cancer (CC). Although the EGF-EGFR pathway has been studied for decades, preventing tumor growth and recurrence caused by peripheral EGF remains a great challenge. In this work, a strategy is proposed to reduce the stimulation of high concentration EGF on tumor growth by using a thermo-sensitive hydrogel. The hydrogel is a triblock copolymer composed of polyethylene glycol (PEG) and poly (lactide...
Source: Colloids and Surfaces - March 1, 2024 Category: Biotechnology Authors: Li Piao Peng Xiang Yangyang Zhou Wei Zhao Ting Yang Shan Xia Guanghui Gao Kexin Chen Dan Li Source Type: research

The mechanism of encapsulating curcumin into oleosomes (Lipid Droplets)
Colloids Surf B Biointerfaces. 2024 Feb 27;236:113819. doi: 10.1016/j.colsurfb.2024.113819. Online ahead of print.ABSTRACTOrganisms have evolved intracellular micron-sized lipid droplets to carry and protect lipids and hydrophobic minor compounds in the hydrophilic environment of cells. These droplets can be utilized as carriers of hydrophobic therapeutics by taking advantage of their biological functions. Here, we focus on the potential of plant-derived lipid droplets, known as oleosomes, as carriers for hydrophobic therapeutics, such as curcumin. By spectroscopy and confocal microscopy, we demonstrate that the oleosome m...
Source: Colloids and Surfaces - March 1, 2024 Category: Biotechnology Authors: Umay Sevgi Vardar Johannes H Bitter Constantinos V Nikiforidis Source Type: research

Cu-MSNs and ZnO nanoparticles incorporated poly(ethylene glycol) diacrylate/sodium alginate double network hydrogel for simultaneous enhancement of osteogenic differentiation
In this study, a double network (DN) hydrogel was synthesized using poly(ethylene glycol) diacrylate (PEGDA) and sodium alginate (SA), incorporating copper-doped mesoporous silica nanospheres (Cu-MSNs) and zinc oxide nanoparticles (ZnO NPs). The blending of PEGDA and SA (PS) facilitates the double network and improves the less porous microstructure of pure PEGDA hydrogel. Furthermore, the incorporation of ZnO NPs and Cu-MSNs into the hydrogel network (PS@ZnO/Cu-MSNs) improved the mechanical properties of the hydrogel (Compressive strength = ⁓153 kPa and Young's modulus = ⁓ 1.66 kPa) when compared to PS hydrogel alone (...
Source: Colloids and Surfaces - March 1, 2024 Category: Biotechnology Authors: Esensil Man Hia Se Rim Jang Bikendra Maharjan Jeesoo Park Chan Hee Park Source Type: research

Thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of EGF to inhibit cervical cancer recurrence
Colloids Surf B Biointerfaces. 2024 Feb 16;236:113795. doi: 10.1016/j.colsurfb.2024.113795. Online ahead of print.ABSTRACTOverexpression of epidermal growth factor receptor (EGFR) in cancer is a key cause of recurrence of cervical cancer (CC). Although the EGF-EGFR pathway has been studied for decades, preventing tumor growth and recurrence caused by peripheral EGF remains a great challenge. In this work, a strategy is proposed to reduce the stimulation of high concentration EGF on tumor growth by using a thermo-sensitive hydrogel. The hydrogel is a triblock copolymer composed of polyethylene glycol (PEG) and poly (lactide...
Source: Colloids and Surfaces - March 1, 2024 Category: Biotechnology Authors: Li Piao Peng Xiang Yangyang Zhou Wei Zhao Ting Yang Shan Xia Guanghui Gao Kexin Chen Dan Li Source Type: research

The mechanism of encapsulating curcumin into oleosomes (Lipid Droplets)
Colloids Surf B Biointerfaces. 2024 Feb 27;236:113819. doi: 10.1016/j.colsurfb.2024.113819. Online ahead of print.ABSTRACTOrganisms have evolved intracellular micron-sized lipid droplets to carry and protect lipids and hydrophobic minor compounds in the hydrophilic environment of cells. These droplets can be utilized as carriers of hydrophobic therapeutics by taking advantage of their biological functions. Here, we focus on the potential of plant-derived lipid droplets, known as oleosomes, as carriers for hydrophobic therapeutics, such as curcumin. By spectroscopy and confocal microscopy, we demonstrate that the oleosome m...
Source: Colloids and Surfaces - March 1, 2024 Category: Biotechnology Authors: Umay Sevgi Vardar Johannes H Bitter Constantinos V Nikiforidis Source Type: research

Cu-MSNs and ZnO nanoparticles incorporated poly(ethylene glycol) diacrylate/sodium alginate double network hydrogel for simultaneous enhancement of osteogenic differentiation
In this study, a double network (DN) hydrogel was synthesized using poly(ethylene glycol) diacrylate (PEGDA) and sodium alginate (SA), incorporating copper-doped mesoporous silica nanospheres (Cu-MSNs) and zinc oxide nanoparticles (ZnO NPs). The blending of PEGDA and SA (PS) facilitates the double network and improves the less porous microstructure of pure PEGDA hydrogel. Furthermore, the incorporation of ZnO NPs and Cu-MSNs into the hydrogel network (PS@ZnO/Cu-MSNs) improved the mechanical properties of the hydrogel (Compressive strength = ⁓153 kPa and Young's modulus = ⁓ 1.66 kPa) when compared to PS hydrogel alone (...
Source: Colloids and Surfaces - March 1, 2024 Category: Biotechnology Authors: Esensil Man Hia Se Rim Jang Bikendra Maharjan Jeesoo Park Chan Hee Park Source Type: research

Tumor microenvironment-activatable nanocatalysts with chemodynamic therapy and enhanced autophagy for specific treatment of oral squamous cell carcinoma
This study presents a targeted treatment strategy for OSCC tumors while sparing normal cells, offering a potential alternative in the realm of adjuvant therapy.PMID:38422665 | DOI:10.1016/j.colsurfb.2023.113713 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - February 29, 2024 Category: Biotechnology Authors: Hongtao Xu Chongyang Zheng Zhiyuan Zhang Xiaojuan Huang Source Type: research

Enhancing immune modulation and bone regeneration on titanium implants by alleviating the hypoxic microenvironment and releasing bioactive ions
Colloids Surf B Biointerfaces. 2024 Feb 17;236:113805. doi: 10.1016/j.colsurfb.2024.113805. Online ahead of print.ABSTRACTBone implantation inevitably causes damage to surrounding vasculature, resulting in a hypoxic microenvironment that hinders bone regeneration. Although titanium (Ti)-based devices are widely used as bone implants, their inherent bioinert surface leads to poor osteointegration. Herein, a strontium peroxide (SrO2)-decorated Ti implant, Ti_P@SrO2, was constructed through coating with poly-L-lactic acid (PLLA) to alleviate the hypoxic microenvironment and transform the bioinert surface of the implant into a...
Source: Colloids and Surfaces - February 29, 2024 Category: Biotechnology Authors: Dongdong Zhang Han Liu Xiaodong Xue Feihong Liu Jun Wu Feng Peng Donghui Wang Haobo Pan Mei Li Source Type: research

Development of pH-freshness smart label based on gellan gum film incorporated with red cabbage anthocyanins extract and its application in postharvest mushroom
Colloids Surf B Biointerfaces. 2024 Feb 28;236:113830. doi: 10.1016/j.colsurfb.2024.113830. Online ahead of print.ABSTRACTNovel colorimetric films based on gellan gum (GG) containing red cabbage anthocyanins extract (RCAE) were prepared as pH-freshness smart labels for real-time visual detection of mushroom freshness. The GG/RCAE films had excellent pH and ammonia sensitivity. The GG/RCAE-0.2-0.3 films had the highest sensitivity to acetic acid. The SEM micrographs, AFM images, FT-IR and XRD spectra demonstrated that RCAE were successfully combined into the film-forming substrate. The incorporation of RCAE resulted in the ...
Source: Colloids and Surfaces - February 29, 2024 Category: Biotechnology Authors: Shouqing Zhan Fangxuan Yi Fanyun Hou Lisha Song Xiuxiu Chen Hai Jiang Xiangbo Han Xia Sun Zhanli Liu Source Type: research