Telmisartan loading thermosensitive hydrogel repairs gut epithelial barrier for alleviating inflammatory bowel disease
In conclusion, Tel-loaded hydrogel demonstrates substantial promise as a potential treatment modality for IBD.PMID:38367290 | DOI:10.1016/j.colsurfb.2024.113799 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - February 17, 2024 Category: Biotechnology Authors: Lu Xu Qin Zhao Yiqiong Xie Ge Bai Hongwen Liu Qi Chen Hongjue Duan Lishan Wang Hang Xu Yuxiang Sun Gao Ling Weihong Ge Yun Zhu Source Type: research

Specific anion effects on urease activity: A Hofmeister study
This study may cast light on an alternative therapy for Helicobacter pylori infections and contribute to the design of innovative materials and provide new approaches for the modulation of the enzymatic activity.PMID:38367291 | DOI:10.1016/j.colsurfb.2024.113789 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - February 17, 2024 Category: Biotechnology Authors: Mert Acar Duccio Tatini Marcello A Budroni Barry W Ninham Mauro Rustici Federico Rossi Pierandrea Lo Nostro Source Type: research

Dentin surface modification by MDP to improve dentin bonding stability: Topological enhancement and mineralization of collagen structure in hybrid layers
The objective of the research was to investigate the role and process of remaining calcium salts in the priming procedure and their capacity for remineralization. The investigation focused on the variations in topological structure, mechanical properties, and chemical interactions between the main agent and the dentin surface. Two adhesive modes including prime-and-rinse(P&R) and prime-and-nonrinse (P&NR) utilized to evaluate the bonding performance and remineralization ability. The findings indicated that both P&R and P&NR methods could eliminate the smear-layer, uncover dentinal-tubules, and generate a te...
Source: Colloids and Surfaces - February 16, 2024 Category: Biotechnology Authors: Ying Shi Haiyan Zheng Wenting Wang Linna Qian Weijia Zhao Jingqiu Xu Mingxing Li Zhifang Wu Baiping Fu Source Type: research

Impact of UV radiation on Mxene-mediated tubulin dissociation and mitochondrial apoptosis in breast cancer cells
In this study, we investigated the apoptotic activity of MXene and UV-irradiated MXene in MCF-7 breast cancer cells by treating them with varying concentrations of MXene. The cytotoxicity of MXene and UV was evaluated by analyzing cellular morphology, nuclei condensation, caspase activation, and apoptotic cell death. We also assessed the effect of the combined treatment on the expression and cellular distribution of Tubulin, a key component of microtubules required for cell division. At low concentrations of MXene (up to 100 µg/ml), the level of cytotoxicity in MCF-7 cells was low. However, the combined treatment of MXene...
Source: Colloids and Surfaces - February 16, 2024 Category: Biotechnology Authors: Ee Wern Tan Samson Eugin Simon Arshid Numan Mohammad Khalid Kuan Onn Tan Source Type: research

Low temperature synthesis of chiral carbon dots for reducing H < sub > 2 < /sub > O < sub > 2 < /sub > damage
Colloids Surf B Biointerfaces. 2024 Feb 5;235:113784. doi: 10.1016/j.colsurfb.2024.113784. Online ahead of print.ABSTRACTRecently, researches focused towards the chiral nanostructures have attracted vast attention. However, the synthesis of chiral carbon dots (CDs) through one-step method is still rather scarce. Herein, a universal approach to green synthesis of chiral CDs at low temperature was proposed. In brief, L-FruCDs and D-FruCDs were obtained by only heating the fructose and chiral cysteine molecules in the sodium hydroxide aqueous solution under atmospheric pressure. Circular dichroism spectra show that these prep...
Source: Colloids and Surfaces - February 16, 2024 Category: Biotechnology Authors: Beibei Wang Yuying Wang Xiaoyang Zhang Yi Liu Source Type: research

Dentin surface modification by MDP to improve dentin bonding stability: Topological enhancement and mineralization of collagen structure in hybrid layers
The objective of the research was to investigate the role and process of remaining calcium salts in the priming procedure and their capacity for remineralization. The investigation focused on the variations in topological structure, mechanical properties, and chemical interactions between the main agent and the dentin surface. Two adhesive modes including prime-and-rinse(P&R) and prime-and-nonrinse (P&NR) utilized to evaluate the bonding performance and remineralization ability. The findings indicated that both P&R and P&NR methods could eliminate the smear-layer, uncover dentinal-tubules, and generate a te...
Source: Colloids and Surfaces - February 16, 2024 Category: Biotechnology Authors: Ying Shi Haiyan Zheng Wenting Wang Linna Qian Weijia Zhao Jingqiu Xu Mingxing Li Zhifang Wu Baiping Fu Source Type: research

Impact of UV radiation on Mxene-mediated tubulin dissociation and mitochondrial apoptosis in breast cancer cells
In this study, we investigated the apoptotic activity of MXene and UV-irradiated MXene in MCF-7 breast cancer cells by treating them with varying concentrations of MXene. The cytotoxicity of MXene and UV was evaluated by analyzing cellular morphology, nuclei condensation, caspase activation, and apoptotic cell death. We also assessed the effect of the combined treatment on the expression and cellular distribution of Tubulin, a key component of microtubules required for cell division. At low concentrations of MXene (up to 100 µg/ml), the level of cytotoxicity in MCF-7 cells was low. However, the combined treatment of MXene...
Source: Colloids and Surfaces - February 16, 2024 Category: Biotechnology Authors: Ee Wern Tan Samson Eugin Simon Arshid Numan Mohammad Khalid Kuan Onn Tan Source Type: research

Low temperature synthesis of chiral carbon dots for reducing H < sub > 2 < /sub > O < sub > 2 < /sub > damage
Colloids Surf B Biointerfaces. 2024 Feb 5;235:113784. doi: 10.1016/j.colsurfb.2024.113784. Online ahead of print.ABSTRACTRecently, researches focused towards the chiral nanostructures have attracted vast attention. However, the synthesis of chiral carbon dots (CDs) through one-step method is still rather scarce. Herein, a universal approach to green synthesis of chiral CDs at low temperature was proposed. In brief, L-FruCDs and D-FruCDs were obtained by only heating the fructose and chiral cysteine molecules in the sodium hydroxide aqueous solution under atmospheric pressure. Circular dichroism spectra show that these prep...
Source: Colloids and Surfaces - February 16, 2024 Category: Biotechnology Authors: Beibei Wang Yuying Wang Xiaoyang Zhang Yi Liu Source Type: research

Invitro anti-biofilm activity and the artificial chaperone activity of quinoline-based ionic liquids
Colloids Surf B Biointerfaces. 2024 Feb 1;235:113773. doi: 10.1016/j.colsurfb.2024.113773. Online ahead of print.ABSTRACTThe maintenance of protein conformation under stressful conditions is one of the prevailing challenges. This has led to a rapid growth in the ingenious protein therapies, in the past few decades, prioritizing the investigation of the structure and function of proteins in novel environments. Ionic Liquids (ILs) are currently dominating the biomedical industry, by endowing great solubility and stability to bio-molecules, especially proteins. Recently, researchers have devoted their attention towards the ar...
Source: Colloids and Surfaces - February 13, 2024 Category: Biotechnology Authors: Kajal Sharma Meenakshi Sharma Source Type: research

Coaxial nanofibers encapsulated with Ampelopsis brevipedunculata extract and green synthesized AgNPs for wound repair
Colloids Surf B Biointerfaces. 2024 Jan 29;235:113771. doi: 10.1016/j.colsurfb.2024.113771. Online ahead of print.ABSTRACTSilver nanoparticles (AgNPs) synthesized from Aloe vera extract exhibited a pronounced antibacterial effect, while the Ampelopsis brevipedunculata extract (ABE) showcased a high antioxidant capacity for wound healing. Spherical AgNPs with a particle size of 28.82 nm crystallized in a face-centered-cubic lattice. AgNPs/polyvinyl alcohol (PVA) and ABE/polycaprolactone (PCL) underwent electrospinning to produce coaxial and electrosprayed nanofibers, respectively. The developed coaxial nanofibers demonstrat...
Source: Colloids and Surfaces - February 13, 2024 Category: Biotechnology Authors: Te-Yang Huang Jr-Ying Lin Wen-Ta Su Source Type: research

Invitro anti-biofilm activity and the artificial chaperone activity of quinoline-based ionic liquids
Colloids Surf B Biointerfaces. 2024 Feb 1;235:113773. doi: 10.1016/j.colsurfb.2024.113773. Online ahead of print.ABSTRACTThe maintenance of protein conformation under stressful conditions is one of the prevailing challenges. This has led to a rapid growth in the ingenious protein therapies, in the past few decades, prioritizing the investigation of the structure and function of proteins in novel environments. Ionic Liquids (ILs) are currently dominating the biomedical industry, by endowing great solubility and stability to bio-molecules, especially proteins. Recently, researchers have devoted their attention towards the ar...
Source: Colloids and Surfaces - February 13, 2024 Category: Biotechnology Authors: Kajal Sharma Meenakshi Sharma Source Type: research

Coaxial nanofibers encapsulated with Ampelopsis brevipedunculata extract and green synthesized AgNPs for wound repair
Colloids Surf B Biointerfaces. 2024 Jan 29;235:113771. doi: 10.1016/j.colsurfb.2024.113771. Online ahead of print.ABSTRACTSilver nanoparticles (AgNPs) synthesized from Aloe vera extract exhibited a pronounced antibacterial effect, while the Ampelopsis brevipedunculata extract (ABE) showcased a high antioxidant capacity for wound healing. Spherical AgNPs with a particle size of 28.82 nm crystallized in a face-centered-cubic lattice. AgNPs/polyvinyl alcohol (PVA) and ABE/polycaprolactone (PCL) underwent electrospinning to produce coaxial and electrosprayed nanofibers, respectively. The developed coaxial nanofibers demonstrat...
Source: Colloids and Surfaces - February 13, 2024 Category: Biotechnology Authors: Te-Yang Huang Jr-Ying Lin Wen-Ta Su Source Type: research

AIE luminogen labeled polymeric micelles for biological imaging and chemotherapy
In this study, an amphiphilic polymer FA-CS-DBA-CHO with aggregation-induced emission (AIE) feature was prepared by introducing 4-(diphenylamino)benzaldehyde derivative (DBA-CHO), imine bond and folic acid (FA) to the molecular structure of chitosan (CS). The amphiphilicity drove the polymer to self-assemble into micelles, and paclitaxel (PTX) could be solubilized in the hydrophobic core. Due to the excellent AIE effect, FA-CS-DBA-CHO exhibited strong cellular imaging capability. The pH-sensitive imine bond in the polymer allowed for accurate drug release in acidic environment. Both in vitro and in vivo studies demonstrate...
Source: Colloids and Surfaces - February 10, 2024 Category: Biotechnology Authors: Na Liang Yingxue Xu Wei Zhao Zhenrong Liu Gang Li Shaoping Sun Source Type: research

Development, characterization, and evaluation of the antioxidant activity of nanocarriers based on surfactant swollen micelles that encapsulate essential oils
In conclusion, the SMs-2 method emerged as an effective approach for producing efficient nanocarriers for EOs, signifying a promising path for future developments in antioxidant delivery systems.PMID:38340418 | DOI:10.1016/j.colsurfb.2024.113783 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - February 10, 2024 Category: Biotechnology Authors: Agustina Delmonte Flavia F Visentini Jos é L Fernández Liliana G Santiago Adri án A Perez Source Type: research

Tannic acid- and N-acetylcysteine-chitosan-modified magnetic nanoparticles reduce hepatic oxidative stress in prediabetic rats
Colloids Surf B Biointerfaces. 2024 Feb 7;235:113791. doi: 10.1016/j.colsurfb.2024.113791. Online ahead of print.ABSTRACTMagnetic nanoparticles (MNPs) modified with tannic acid (TA) have shown remarkable success as an antioxidant and antimicrobial therapeutic agent. Herein, we report a synthetic procedure for the preparation of silica-coated MNPs modified with N-acetylcysteine-modified chitosan and TA. This was achieved by free-radical grafting of NAC onto chitosan (CS), a layer-by-layer technique for modifying negatively charged MNP@SiO2 nanoparticles with positively charged CS-NAC, and crosslinking CS with TA. The antiox...
Source: Colloids and Surfaces - February 9, 2024 Category: Biotechnology Authors: Ma łgorzata Świętek Irena Markov á Hana Mal ínská Martina H üttl Denisa Mikl ánková Krist ýna Černá Rafa ł Konefał Daniel Hor ák Source Type: research