Promising biomedical systems based on copper nanoparticles: Synthesis, characterization, and applications
Colloids Surf B Biointerfaces. 2024 Mar 24;237:113861. doi: 10.1016/j.colsurfb.2024.113861. Online ahead of print.ABSTRACTCopper and copper oxide nanoparticles (CuNPs) have unique physicochemical properties that make them highly promising for biomedical applications. This review discusses the application of CuNPs in biomedicine, including diagnosis, therapy, and theranostics. Recent synthesis methods, with an emphasis on green approaches, are described, and the latest techniques for nanoparticle characterization are critically analyzed. CuNPs, including Cu2O, CuO, and Cu, have significant potential as anti-cancer agents, d...
Source: Colloids and Surfaces - March 29, 2024 Category: Biotechnology Authors: Andrey Vodyashkin Anastasia Stoinova Parfait Kezimana Source Type: research
Curcumin/TGF- β1 siRNA loaded solid lipid nanoparticles alleviate cerebral injury after intracerebral hemorrhage by transnasal brain targeting
In conclusion, our designed siRNA/CUR@SLN showed good brain targeting and anti-inflammatory effect ability after nasal administration, which lays the foundation for the treatment of inflammation caused by ICH and offers a novel approach for brain-targeted drug delivery and brings new hope.PMID:38552289 | DOI:10.1016/j.colsurfb.2024.113857 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - March 29, 2024 Category: Biotechnology Authors: Munire Abudurexiti Jun Xue Xianzhe Li Xiaofeng Zhang Yongyi Qiu Senjie Xiong Guojing Liu Sangui Yuan Rongrui Tang Source Type: research
Lipase in-situ immobilized in covalent organic framework: Enzymatic properties and application in the preparation of 1, 3-dioleoyl-2-palmitoylglycerol
In this study, the critical importance of designing an appropriate immobilized carrier and method for free lipase to ensure exceptional biological catalytic activity and stability was emphasized. Covalent organic frameworks (COF-1) were synthesized as a novel porous carrier with an azine structure (-CN-NC-) through the condensation of hydrazine hydrate and benzene-1,3,5-tricarbaldehyde at room temperature. Simultaneously, Rhizomucor miehei lipase (RML) was immobilized within the COF-1 carrier using an in-situ aqueous phase method. Characterization of the carrier and RML@COF-1 and evaluation of the lipase properties of RML ...
Source: Colloids and Surfaces - March 29, 2024 Category: Biotechnology Authors: Ting Feng Jiani Shi Jiaojiao Xia Xuemei Ren Onyinye Idowu Adesanya Hongbo Suo Bin Zou Source Type: research
Laser-assisted synthesis of nano-hydroxyapatite and functionalization with bone active molecules for bone regeneration
Colloids Surf B Biointerfaces. 2024 Mar 18;237:113859. doi: 10.1016/j.colsurfb.2024.113859. Online ahead of print.ABSTRACTThe main goal of bone tissue engineering research is to replace the allogenic and autologous bone graft substitutes that can promote bone repair. Owing to excellent biocompatibility and osteoconductivity, hydroxyapatite is in extensive research and high demand for both medical and non-medical applications. Although various methods have been developed for the synthesis of hydroxyapatite, in the present study we have shown the use of nanosecond laser energy in the wet precipitation method of nano-hydroxya...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Shazia Shaikh Sneha Gupta Ankita Mishra Parvaiz A Sheikh Prerna Singh Ashok Kumar Source Type: research
Ibrutinib topical delivery for melanoma treatment: The effect of nanostructured lipid carriers' composition on the controlled drug skin deposition
This study proposes developing and comparing the performance of two compositions of nanostructured lipid carriers (NLCs) to load IBR for the topical management of melanomas in their early stages. Initially, the effectiveness of IBR on melanoma proliferation was evaluated in vitro, and the results confirmed that the drug reduces the viability of human melanoma cells by inducing apoptosis at a dose that does not compromise dermal cells. Preformulation tests were then conducted to characterize the physical compatibility between the drug and the selected components used in NLCs preparation. Sequentially, two lipid compositions...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Lucas F F Albuquerque Fernanda V Lins Elizabete C I Bispo Elly êssa N Borges Mateus T Silva Ta ís Gratieri Marc ílio Cunha-Filho Antonio Alonso Juliana L Carvalho Felipe Saldanha-Araujo Guilherme M Gelfuso Source Type: research
A pH-sensitive imidazole grafted polymeric micelles nanoplatform based on ROS amplification for ferroptosis-enhanced chemodynamic therapy
Colloids Surf B Biointerfaces. 2024 Mar 21;237:113871. doi: 10.1016/j.colsurfb.2024.113871. Online ahead of print.ABSTRACTHighly toxic reactive oxygen species (ROS), crucial in inducing apoptosis and ferroptosis, are pivotal for cell death pathways in cancer therapy. However, the effectiveness of ROS-related tumor therapy is impeded by the limited intracellular ROS and substrates, coupled with the presence of abundant ROS scavengers like glutathione (GSH). In this research, we developed acid-responsive, iron-coordinated polymer nanoparticles (PPA/TF) encapsulating a mitochondrial-targeting drug alpha-tocopheryl succinate (...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Zhuangzhuang Zhang Lingyang Wang Zhaoyuan Guo Yong Sun Jianqin Yan Source Type: research
Lipid-Polymer Hybrid Nanoparticles Synthesized via Lipid-Based Surface Engineering for a robust drug delivery platform
Colloids Surf B Biointerfaces. 2024 Mar 19;237:113858. doi: 10.1016/j.colsurfb.2024.113858. Online ahead of print.ABSTRACTHerein, lipid-polymer core-shell hybrid nanoparticles composed of poly(D,L-lactic-co-glycolic acid) (PLGA)/lecithin (PLNs) were synthesized through lipid-based surface engineering. Lipids were absorbed onto the surface of the PLGA core to enhance the advantages of polymeric nanoparticles and liposomes. The amounts of lipids and encapsulation of the drug nicardipine hydrochloride (NCH) in the PLNs were studied. NCH-loaded PLNs (NCH-PLNs) were produced in high yield (66%) with a high encapsulation efficie...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Nopparuj Soomherun Narumol Kreua-Ongarjnukool Saowapa Thumsing Niyomthai Sorayouth Chumnanvej Source Type: research
Laser-assisted synthesis of nano-hydroxyapatite and functionalization with bone active molecules for bone regeneration
Colloids Surf B Biointerfaces. 2024 Mar 18;237:113859. doi: 10.1016/j.colsurfb.2024.113859. Online ahead of print.ABSTRACTThe main goal of bone tissue engineering research is to replace the allogenic and autologous bone graft substitutes that can promote bone repair. Owing to excellent biocompatibility and osteoconductivity, hydroxyapatite is in extensive research and high demand for both medical and non-medical applications. Although various methods have been developed for the synthesis of hydroxyapatite, in the present study we have shown the use of nanosecond laser energy in the wet precipitation method of nano-hydroxya...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Shazia Shaikh Sneha Gupta Ankita Mishra Parvaiz A Sheikh Prerna Singh Ashok Kumar Source Type: research
Ibrutinib topical delivery for melanoma treatment: The effect of nanostructured lipid carriers' composition on the controlled drug skin deposition
This study proposes developing and comparing the performance of two compositions of nanostructured lipid carriers (NLCs) to load IBR for the topical management of melanomas in their early stages. Initially, the effectiveness of IBR on melanoma proliferation was evaluated in vitro, and the results confirmed that the drug reduces the viability of human melanoma cells by inducing apoptosis at a dose that does not compromise dermal cells. Preformulation tests were then conducted to characterize the physical compatibility between the drug and the selected components used in NLCs preparation. Sequentially, two lipid compositions...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Lucas F F Albuquerque Fernanda V Lins Elizabete C I Bispo Elly êssa N Borges Mateus T Silva Ta ís Gratieri Marc ílio Cunha-Filho Antonio Alonso Juliana L Carvalho Felipe Saldanha-Araujo Guilherme M Gelfuso Source Type: research
A pH-sensitive imidazole grafted polymeric micelles nanoplatform based on ROS amplification for ferroptosis-enhanced chemodynamic therapy
Colloids Surf B Biointerfaces. 2024 Mar 21;237:113871. doi: 10.1016/j.colsurfb.2024.113871. Online ahead of print.ABSTRACTHighly toxic reactive oxygen species (ROS), crucial in inducing apoptosis and ferroptosis, are pivotal for cell death pathways in cancer therapy. However, the effectiveness of ROS-related tumor therapy is impeded by the limited intracellular ROS and substrates, coupled with the presence of abundant ROS scavengers like glutathione (GSH). In this research, we developed acid-responsive, iron-coordinated polymer nanoparticles (PPA/TF) encapsulating a mitochondrial-targeting drug alpha-tocopheryl succinate (...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Zhuangzhuang Zhang Lingyang Wang Zhaoyuan Guo Yong Sun Jianqin Yan Source Type: research
Lipid-Polymer Hybrid Nanoparticles Synthesized via Lipid-Based Surface Engineering for a robust drug delivery platform
Colloids Surf B Biointerfaces. 2024 Mar 19;237:113858. doi: 10.1016/j.colsurfb.2024.113858. Online ahead of print.ABSTRACTHerein, lipid-polymer core-shell hybrid nanoparticles composed of poly(D,L-lactic-co-glycolic acid) (PLGA)/lecithin (PLNs) were synthesized through lipid-based surface engineering. Lipids were absorbed onto the surface of the PLGA core to enhance the advantages of polymeric nanoparticles and liposomes. The amounts of lipids and encapsulation of the drug nicardipine hydrochloride (NCH) in the PLNs were studied. NCH-loaded PLNs (NCH-PLNs) were produced in high yield (66%) with a high encapsulation efficie...
Source: Colloids and Surfaces - March 28, 2024 Category: Biotechnology Authors: Nopparuj Soomherun Narumol Kreua-Ongarjnukool Saowapa Thumsing Niyomthai Sorayouth Chumnanvej Source Type: research
An antimicrobial film of silver/nanocellulose crystal/oxalic acid/polyvinyl alcohol with real-time bactericidal and prevention of biofilm formation properties
In this study, OA/PVA was obtained by cross-linking oxalic acid (OA) with polyvinyl alcohol (PVA). Then Ag/NCC was obtained by in situ reduction of AgNPs on nanocellulose crystals (NCC). Finally, Ag/NCC/OA/PVA composite antimicrobial films with good waterproofing effect were prepared by mixing Ag/NCC with OA/PVA. Subsequently, the films were characterized using SEM, UV-vis, FTIR and XRD, as well as physicochemical properties such as mechanical strength and hydrophilic properties were determined. The results indicated that the Ag/NCC/OA/PVA films possess good light transmittance, mechanical properties, water resistance, ant...
Source: Colloids and Surfaces - March 24, 2024 Category: Biotechnology Authors: Hui Li Xianxiang Zeng Ting Yao Hengyi Xu Source Type: research
Interfacial blending in co-axially electrospun polymer core-shell fibers and their interaction with cells via focal adhesion point analysis
This study addresses a key challenge in core-shell fiber design related to the blending effect between core and shell polymers. Two types of fibers, PMMA and core-shell PC-PMMA, were electrospun, and thorough analyses confirmed the desired core-shell structure in PC-PMMA fibers. Surface chemistry analysis revealed PC diffusion to the PMMA shell of the core-shell fiber during electrospinning, subsequently prompting an investigation of the fiber's surface potential. Conducting cellular studies on osteoblasts by super-resolution confocal microscopy provided insights into the direct influence of interfacial polymer blending an...
Source: Colloids and Surfaces - March 24, 2024 Category: Biotechnology Authors: Martyna Polak Daniel P Ura Krzysztof Berniak Piotr K Szewczyk Mateusz M Marzec Urszula Stachewicz Source Type: research
Hawthorn pectin/soybean isolate protein hydrogel bead as a promising ferrous ion-embedded delivery system
In conclusion, a novel and efficient ferrous ion delivery system was developed using SPI and HP, demonstrating the potential application of SPI/HP-Fe (II) hydrogel beads as an iron supplement to overcome the inefficiency of intake of conventional iron supplements.PMID:38522284 | DOI:10.1016/j.colsurfb.2024.113867 (Source: Colloids and Surfaces)
Source: Colloids and Surfaces - March 24, 2024 Category: Biotechnology Authors: Wenxian Sun Kaixuan Bu Huangmei Meng Chuanhe Zhu Source Type: research
Emerging application of nanomedicine-based therapy in acute respiratory distress syndrome
Colloids Surf B Biointerfaces. 2024 Mar 21;237:113869. doi: 10.1016/j.colsurfb.2024.113869. Online ahead of print.ABSTRACTAcute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are serious lung injuries caused by various factors, leading to increased permeability of the alveolar-capillary barrier, reduced stability of the alveoli, inflammatory response, and hypoxemia. Despite several decades of research since ARDS was first formally described in 1967, reliable clinical treatment options are still lacking. Currently, supportive therapy and mechanical ventilation are prioritized, and there is no medication th...
Source: Colloids and Surfaces - March 24, 2024 Category: Biotechnology Authors: Yitianhe Xu Leyao Lv Qian Wang Qing Yao Longfa Kou Hailin Zhang Source Type: research
