IGF2BP3 promotes glutamine metabolism of endometriosis by interacting with UCA1 to enhances the mRNA stability of GLS1
CONCLUSION: These discoveries underscored the critical involvement of IGF2BP3 in the elevation and stability of GLS1 mRNA in the context of glutamine metabolism by interacting with UCA1 in EMs. The implications of our study extended to the identification of possible therapeutic targets for individuals with EMs.PMID:38760723 | DOI:10.1186/s10020-024-00834-7 (Source: Molecular Medicine)
Source: Molecular Medicine - May 17, 2024 Category: Molecular Biology Authors: Honglin Wang Yingying Cao Yanling Gou Hao Wang Zongwen Liang Qiong Wu Jiahuan Tan Jinming Liu Zhi Li Jing Cui Huiyan Zhang Zongfeng Zhang Source Type: research
Clinicopathological characteristics and prognostic factors in invasive micropapillary carcinoma of the breast
CONCLUSIONS: The incidence of micropapillary IMPC, among other pathological subtypes, is steadily increasing. ER-positive and PR-positive rates, as well as luminal subtypes, are frequent, with a concurrent increase in the 5-year locoregional recurrence rate. It would be interesting to compare the effect following these therapeutic modifications in larger cohorts in future studies.PMID:38757040 | PMC:PMC11094864 | DOI:10.5114/aoms/173213 (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2024 Category: General Medicine Authors: Yao-Bang Liu Xu-Tong Gao Ling-Yan Huang Xin-Lan Liu Source Type: research
Clinical Significance of a Novel Vasculogenic Mimicry-Based Prognostic Model in Hepatocellular Carcinoma
CONCLUSIONS: The VC score holds the potential to establish individualized treatment plans and clinical management strategies for patients with HCC.PMID:38757323 | DOI:10.2174/0109298673298862240510073543 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 17, 2024 Category: Chemistry Authors: Yifan Zeng Shuwen Jiang Zhuoqi Lou Lin Chen Yongtao Zhang Liya Pan Qingmiao Shi Bing Ruan Source Type: research
Bioassay-guided isolation of cycloartane-type triterpenes, their cytotoxic properties and identification of potential chemical markers from < em > Geniotrigona thoracica < /em > propolis
Nat Prod Res. 2024 May 17:1-6. doi: 10.1080/14786419.2024.2352867. Online ahead of print.ABSTRACTPhytochemical investigation through cytotoxicity bioassay-guided isolation of Geniotrigona thoracica propolis led to the identification of five cycloartane-type triterpenes, including mangiferonic acid 1, ambonic acid 2, mangiferolic acid 3, ambolic acid 4 and cycloartenol 5. Their structures were established based on detailed spectroscopic analysis and comparison with literature data. Compounds 1-5 were isolated for the first time in this species. From cytotoxicity MTT assay, compound 3 inhibited the growth of breast (MCF-7) a...
Source: Natural Product Research - May 17, 2024 Category: Biochemistry Authors: Ainur Awanis Mohd Badiazaman Ahmad Nazif Aziz Habsah Mohamad Khamsah Suryati Mohd Source Type: research
Design, synthesis of combretastatin A-4 piperazine derivatives as potential antitumor agents by inhibiting tubulin polymerization and inducing autophagy in HCT116 cells
Eur J Med Chem. 2024 May 13;272:116497. doi: 10.1016/j.ejmech.2024.116497. Online ahead of print.ABSTRACTA series of combretastatin A-4 (CA-4) derivatives were designed and synthesized, which contain stilbene core structure with different linker, predominantly piperazine derivatives. These compounds were evaluated for their cytotoxic activities against four cancer cell lines, HCT116, A549, AGS, and SK-MES-1. Among them, compound 13 displayed the best effectiveness with IC50 values of 0.227 μM and 0.253 μM against HCT116 and A549 cells, respectively, showing low toxicity to normal cells. Mechanistic studies showed that 13...
Source: European Journal of Medicinal Chemistry - May 17, 2024 Category: Chemistry Authors: Hangqi Zhang Ming Li Xueming Zhou Li Tang Guangying Chen Yongmin Zhang Source Type: research
A long ‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report
Exp Ther Med. 2024 Apr 24;27(6):263. doi: 10.3892/etm.2024.12551. eCollection 2024 Jun.ABSTRACTEstablished treatments for advanced hepatocellular carcinoma (HCC) with Child-Pugh cirrhosis B (CPB, moderate hepatic dysfunction) are lacking. A recently published randomized phase 2 study in CPB HCC investigating the safety and efficacy of namodenoson (25 mg BID), an A3 adenosine-receptor agonist vs. placebo, suggested a favorable safety profile and a positive efficacy signal in patients with HCC with a CPB score of 7 (CPB7). The present study reports a 61-year-old woman with CPB7 HCC who received namodenoson for over 6 years t...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Ioana Adriana Ciurescu Riccardo Lencioni Salomon M Stemmer Motti Farbstein Zivit Harpaz Avital Bareket-Samish Michael H Silverman Pnina Fishman Source Type: research
Screening for ferroptosis genes related to endometrial carcinoma and predicting of targeted drugs based on bioinformatics
Arch Toxicol. 2024 May 17. doi: 10.1007/s00204-024-03783-6. Online ahead of print.ABSTRACTEndometrial carcinoma is one of most common malignant tumors in women, and ferroptosis is closely related to the development and treatment of endometrial carcinoma. The aim of this study was to screen ferroptosis-related genes associated with endometrial carcinoma and predict targeted drugs through bioinformatics. 761 differentially expressed genes were obtained by the dataset GSE63678 from the GEO database, and most of the genes were enriched in the KEGG_CELL_CYCLE and KEGG_OOCYTE_MEIOSIS signaling pathways. 22 ferroptosis-differenti...
Source: Archives of Toxicology - May 17, 2024 Category: Toxicology Authors: Rui Wang Wei Lang Qian Xue Le Zhang Yunzhu Xujia Chaofan Wang Xin Fang Shidi Gao Li Guo Source Type: research
Rare primary neuroendocrine carcinoma of the breast sensitive to neoadjuvant chemotherapy: Case report
Asian J Surg. 2024 May 16:S1015-9584(24)00841-8. doi: 10.1016/j.asjsur.2024.04.159. Online ahead of print.NO ABSTRACTPMID:38760212 | DOI:10.1016/j.asjsur.2024.04.159 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - May 17, 2024 Category: Surgery Authors: Yanhong Dou Pin Gao Di Wu Aiping Shi Source Type: research
Diagnosis and treatment of adenoid cystic carcinoma of Bartholin's gland
Asian J Surg. 2024 May 16:S1015-9584(24)00867-4. doi: 10.1016/j.asjsur.2024.04.185. Online ahead of print.NO ABSTRACTPMID:38760204 | DOI:10.1016/j.asjsur.2024.04.185 (Source: Asian Journal of Surgery)
Source: Asian Journal of Surgery - May 17, 2024 Category: Surgery Authors: Li-Na Xu Bo-Hui Li Chang-He Wang Peng-Mu Xie Source Type: research
Decisional and prognostic impact of diagnostic ureteroscopy in high-risk upper tract urothelial carcinoma: A multi-institutional collaborative analysis (ROBUUST collaborative group)
CONCLUSIONS: The advantage in terms of OS and CSS in patients undergoing preoperative URS could derive from a better selection of candidates for curative treatment. The treatment strategy is likely more influenced by tumor features than by URS findings.PMID:38760274 | DOI:10.1016/j.urolonc.2024.04.021 (Source: Urologic Oncology)
Source: Urologic Oncology - May 17, 2024 Category: Urology & Nephrology Authors: Francesco Ditonno Antonio Franco Alessandro Veccia Riccardo Bertolo Zhenjie Wu Linhui Wang Firas Abdollah Marco Finati Giuseppe Simone Gabriele Tuderti Emma Helstrom Andres Correa Ottavio De Cobelli Matteo Ferro Francesco Porpiglia Daniele Amparore Antoni Source Type: research
Evaluation of image-pro plus assisted superb microvascular imaging for differential diagnosis of renal masses
CONCLUSION: VI was higher in malignant than benign in renal masses. In malignant masses, VI in CCRCC was higher than that in papillary renal cell carcinoma and ChRCC. As a noninvasive examination, it had important clinical significance in the differential diagnosis of renal masses. VI from IPP may assist sonographer in distinguish renal malignances as a quantitative tool for vascularity.PMID:38760275 | DOI:10.1016/j.urolonc.2024.04.026 (Source: Urologic Oncology)
Source: Urologic Oncology - May 17, 2024 Category: Urology & Nephrology Authors: Yiran Mao Tingting Xia Hailing Wang Xi Wei Jie Mu Source Type: research
Meta-analysis of the GALAD model for diagnosing primary hepatocellular carcinoma
CONCLUSION: This meta-analysis confirmed that the GALAD model has excellent diagnostic performance for early-stage and all-stage HCC and can maintain high sensitivity and specificity in early-stage HCC. Therefore, the GALAD model is qualified for screening early-stage canceration from chronic liver disease.PMID:38759033 | DOI:10.3233/THC-231470 (Source: Technology and Health Care)
Source: Technology and Health Care - May 17, 2024 Category: Medical Devices Authors: Jian-Lin Lu Xiao-Yan Yuan Jin-Shan Zhang Yuan Li Source Type: research
Bevacizumab induces ferroptosis and enhances CD8 < sup > + < /sup > T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9
This study provides new insight into the mechanisms by which bevacizumab synergistically modulates ferroptosis and CD8+ T cell immune activity in liver cancer.PMID:38760543 | DOI:10.1038/s41401-024-01299-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2024 Category: Drugs & Pharmacology Authors: Chun-Yu Hou Pan Lv Hong-Feng Yuan Li-Na Zhao Yu-Fei Wang Hui-Hui Zhang Guang Yang Xiao-Dong Zhang Source Type: research
Incidence, mortality and survival in people with Merkel cell carcinoma: a systematic review
Br J Dermatol. 2024 May 17;190(6):e64. doi: 10.1093/bjd/ljae159.NO ABSTRACTPMID:38758058 | DOI:10.1093/bjd/ljae159 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2024 Category: Dermatology Source Type: research
A combination of radiomic features, clinic characteristics, and serum tumor biomarkers to predict the possibility of the micropapillary/solid component of lung adenocarcinoma
CONCLUSION: This study has developed and validated a combined nomogram, a visual tool that integrates CT radiomics features with clinical indicators and serum tumor biomarkers. This innovative model facilitates the differentiation of micropapillary or solid components within lung adenocarcinoma and achieves a higher AUC, indicating superior predictive accuracy.PMID:38757628 | DOI:10.1177/17534666241249168 (Source: Cancer Control)
Source: Cancer Control - May 17, 2024 Category: Cancer & Oncology Authors: Xiaowei Xing Liangping Li Mingxia Sun Xinhai Zhu Yue Feng Source Type: research
