Gelatin-based coating enriched with blueberry juice preserves the nutraceutical quality and reduces the microbial contamination of tomato fruit.
Abstract To preserve quality and extend the shelf life of tomato, a bioactive edible coating was prepared using gelatin wastes from pharmaceutical industry and lyophilised blueberry juice (BJ). The effectiveness of gelatin-coating (G) and G enriched with blueberry juice (GB) was tested, monitoring carotenoids, polyphenols and flavonoids content, the antioxidant activity and the antimicrobial efficiency of coating against the native microflora. After 7 d of storage, coated fruit showed higher phenolic and flavonoids content and increased antioxidant activity, while carotenoids were unaffected by the treatments. The...
Source: Natural Product Research - September 17, 2020 Category: Biochemistry Authors: Frassinetti S, Castagna A, Santin M, Pozzo L, Baratto I, Longo V, Ranieri A Tags: Nat Prod Res Source Type: research

Flavonoid glycosides from the nectar of Camellia reticulata Lindl.
Abstract The nectar of Camellia reticulata Lindl. contains sugar, amino acids and other nutritional components, suggesting that it could be developed for food and food additives. To understand the effects of the nectar on human health, we investigated its chemical constituents. Two new flavonoid glycosides, cameretiins A and B (1 and 2), and two known flavonoid glycosides, kaempferol 3-O-(2''-O-E-p-coumaroyl)-β-D-glucopyranoside (3) and tiliroside (4) were obtained from the nectar of Camellia reticulata Lindl. Their structures were determined based on analysis of their spectroscopic data and by comparison wit...
Source: Natural Product Research - September 17, 2020 Category: Biochemistry Authors: Chen XL, Peng XR, Gong XY, Liu YQ, Qing Z, Ren XX, Su R, Fang LM, Qiu MH, Dong K Tags: Nat Prod Res Source Type: research

Anticancer and antimicrobial compounds from Croton caudatus Gieseler and Eurya acuminata DC: Two edible plants used in the traditional medicine of the Kuki tribes.
Abstract Eurya acuminata DC and Croton caudatus Gieseler are two ethno-medicinal plants used by Kuki community of North East India. From these plants, we have characterized fifteen phytochemicals (1-15) by extensive use of chromatographic and spectroscopic methods. They were also tested for in vitro cytotoxic effects against A549 and MIAPACA2 cell lines and antimicrobial activities against Mycobacterium smegmatis and Candida albicans. All compounds showed moderate activity against the MIAPACA2 cell lines. Compounds tricosan-1-ol (6), octacosanoic acid (7), β-sitosterol (10) and (E)-dodec-3-en-1-ol (14) exhibi...
Source: Natural Product Research - September 16, 2020 Category: Biochemistry Authors: Neipihoi, Narzary B, Saikia S, Saikia S, Tamuli KJ, Sahoo RK, Dutta D, Bordoloi M Tags: Nat Prod Res Source Type: research

Chemical composition of three Malaysian Horsfieldia essential oils.
This study aims to assess the chemical compositions of the essential oils from three Horsfieldia species namely H. fulva Warb., H. sucosa Warb. and H. superba Warb., which are found in Malaysia. The essential oils were derived from the samples through hydrodistillation which were then characterised by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). Based on the findings, the H. fulva, H. sucosa and H. superba essential oils represented 98.2%, 98.7% and 98.5% of the total oils, respectively. The major component of H. fulva oil was identified to be germacrene D (20.8%), H. sucosa oil mainly cont...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Salleh WMNHW, Shakri NM, Khamis S, Setzer WN, Nadri MH Tags: Nat Prod Res Source Type: research

Lactoferrin-derived peptides antimicrobial activity: an in vitro experiment.
In this study, in vitro antibacterial and antimicrobial effects of milk-derived antimicrobial agents, lactoferrin-derived peptides, lactoferricin (Lfc) and lactoferrampin (Lfa) (alone or in combination) and their association with natural extracts have been explored. The assessment of antimicrobial activity was based on two measurements: Minimum Inhibitory Concentration and Fractional Inhibitory Concentration indexes. Lfc alone is more suitable for inhibiting Staphylococcus intermedius and Malassezia pachydermatis, while Lfa against Candida albicans, a synergistic effect of the two peptides against all the three pathogens h...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Biasibetti E, Rapacioli S, Bruni N, Martello E Tags: Nat Prod Res Source Type: research

Bioactive compounds derived from the marine-derived fungus MCCC3A00951 and their influenza neuraminidase inhibition activity in vitro and in silico.
Abstract Penicillium polonicum MCCC3A00951 is a fungus with influenza neuraminidase (NA) inhibition activity derived from a sediment of the mangrove forest of Zhangjiangkou in Fujian province, China. Chemical investigation on an ethyl acetate extract of its fermentation led to the isolation of a new compound, 7-hydroxy-3,10-dehydrocyclopeptine (1), and 13 known compounds (2-14). The new compound was comprehensively characterised by high-resolution electrospray ionisation-mass spectrometry, and 1D, 2D nuclear magnetic resonance (NMR) spectra. The anti-influenza NA assay was performed to evaluate the potential biolo...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Liu SZ, He FM, Bin YL, Li CF, Xie BY, Tang XX, Qiu YK Tags: Nat Prod Res Source Type: research

Quinolizidine alkaloids from the roots of Sophora flavescens.
Abstract Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)-Δ 7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported for the first time. In addition, (+)-sophoranol (4) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 μM, while lupanine (17) was found to inhibit the growt...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Li JC, Zhang ZJ, Liu D, Jiang MY, Li RT, Li HM Tags: Nat Prod Res Source Type: research

Wound healing cream formulated with Kalanchoe pinnata major flavonoid is as effective as the aqueous leaf extract cream in a rat model of excisional wound.
This study aimed to develop and compare two creams containing a leaf aqueous extract of K. pinnata (KP; 6%) and its major flavonoid [quercetin 3-O-α-L-arabinopyranosyl-(1→2)-α-L-rhamnopyranoside] (0.15%). Both creams were topically evaluated in a rat excision model for 15 days. On the 12th day, groups treated with KP leaf-extract and KP major flavonoid creams exhibited 95.3 ± 1.2% and 97.5 ± 0.8% of healing, respectively (positive control = 96.7 ± 0.8%; negative control = 76.1 ± 3.8%). Both resulted in better re-epit...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Coutinho MAS, Casanova LM, Nascimento LBDS, Leal D, Palmero C, Toma HK, Dos Santos EP, Nasciutti LE, Costa SS Tags: Nat Prod Res Source Type: research

Synthesis, structural revision, and tyrosinase inhibitory activity of proposed phloretin-4-O- β-D-glucopyranoside from Homalium stenophyllum.
Synthesis, structural revision, and tyrosinase inhibitory activity of proposed phloretin-4-O-β-D-glucopyranoside from Homalium stenophyllum. Nat Prod Res. 2020 Sep 14;:1-9 Authors: Shimakage R, Nihei KI Abstract Phloretin-4-O-β-D-glucopyranoside (1), isolated from Homalium stenophyllum, was synthesized for the first time through aldol condensation and Schmidt glycosylation reactions aiming to develop a novel hydrophilic tyrosinase inhibitor. However, the specific rotation of synthetic 1 was found to be negative and different from that reported for natural product 1. Thus, L-glucoside 2 was c...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Shimakage R, Nihei KI Tags: Nat Prod Res Source Type: research

Apoptotic effect of jaceosidin on MCF-7 human breast cancer cells through modulation of ERK and p38 MAPK pathways.
This study investigated the apoptotic effect of jaceosidin treatment on MCF-7 human breast cancer cells at varying concentrations of (0, 10, 20 and 40 µM) for 24 and 48 h treatment times. Jaceosidin treatment induced a significant (p 
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Ojulari OV, Chae JB, Lee SG, Min K, Kwon TK, Nam JO Tags: Nat Prod Res Source Type: research

Chemical study of Mimosa tenuiflora barks.
In conclusion this study contributes significantly to the standardization of the studied plant material and assists in the use of these data for future development of products from on this forestry species. PMID: 32924595 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Amariz IAE, Pereira ECV, Alencar Filho JMT, Silva JPD, Souza NAC, de Oliveira AP, Rolim LA, Pereira RN Tags: Nat Prod Res Source Type: research

Bacosides enrichment does not improve the anti-amnesic effect of Bacopa monnieri: behavioural and biochemical evidences.
Abstract Bacopa monnieri (L.) Wettst. (BM) has been traditionally used in Ayurveda for improving memory and cognitive deficits which is also evidenced through experimental and clinical studies. The neuropharmacological properties of BM are attributed to "bacosides", a complex mixture of saponin compounds. BM extracts enriched with bacosides offers commercial advantage due to perceived higher efficacy. However, there is no scientific data to support the same. In the present study, methanolic extract of BM (BME) was compared with bacosides enriched (BME-EF) vis a vis bacosides free fraction (BME-FF). Poten...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Arora R, Kumar R, Agarwal A, Gupta YK Tags: Nat Prod Res Source Type: research

Trichocladabiflavone A, a chalcone-flavonone type biflavonoid from Selaginella trichoclada Alsto.
Abstract A chalcone-flavonone type biflavonoid, trichocladabiflavone A (1), along with eight known biflavonoids (2-9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures were elucidated by extensive spectroscopic analyses. Compound 1 was the first chalcone-flavonone type biflavonoid reported in the genus Selaginella. Moreover, compound 1 exhibited moderate cytotoxicity against DU145, MCF-7 and PC3 human cancer cell lines. PMID: 32924604 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Xie Y, Yao XC, Tan LH, Long HP, Xu PS, Li J, Tan GS Tags: Nat Prod Res Source Type: research

Linderolide U, a new sesquiterpene from Lindera aggregata root.
Abstract A new sesquiterpene, namely linderolide U (1), was isolated from the root of Lindera aggregata (Sims) Kosterm along with five known sesquiterpenes (2-6). The structures of the obtained compounds were identified by spectroscopic methods, specifically nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). The acquired data were compared with those previously reported in the literature. The anticancer effects of the isolated natural products were studied using the HCT116 human colon cancer cell line. Compound 5 was found to significantly suppress cell proliferation, which was associated wi...
Source: Natural Product Research - September 14, 2020 Category: Biochemistry Authors: Yang HJ, Kwon EB, Li W Tags: Nat Prod Res Source Type: research

Cuphea spp.: antichemotactic study for a potential anti-inflammatory drug.
Abstract Cuphea genus (Lythraceae) popularly known in Brazil as "sete-sangrias", it's described as antimicrobial, anti-inflammatory, diuretic and antihypertensive mainly. Investigating the chemotactic ability plays an important role in the identification of new anti-inflammatory agents. Thus, this research aims to assay the antichemotactic activity of hydroethanolic extracts of C. calophylla, C. carthagenensis, C. glutinosa, and C. racemosa as well as the compounds miquelianin and myricitrin. The antichemotactic activity of the hydroethanolic extracts, miquelianin, and myricitrin were assayed at concentr...
Source: Natural Product Research - September 11, 2020 Category: Biochemistry Authors: Santos MC, Soares KD, Beltrame BM, Bordignon SAL, Apel MA, Mendez ASL, Henriques AT Tags: Nat Prod Res Source Type: research

Elucidation the binding interaction of hypericin-loaded P84 copolymeric micelles by using 1D and 2D NMR techniques.
ano W Abstract Hypericin (HYP) is an active compound of Hypericum perforatum. Associated with photodynamic therapy (PDT), HYP has shown a broad therapeutic potential against microorganisms and cancer cells. Due to the low water solubility of HYP, its application in the biological medium becomes limited. To solve this limitation, our research group has been used copolymeric micelles to carrier HYP with high efficiency. However, there is no elucidated mechanism for HYP delivery mediated by copolymeric micelles. In this sense, we believed that the study of binding-sites of copolymeric micelles and HYP is the first st...
Source: Natural Product Research - September 11, 2020 Category: Biochemistry Authors: Gonçalves RS, de Oliveira ACV, Hioka N, Caetano W Tags: Nat Prod Res Source Type: research

Two new chemical constituents from the rhizomes of Actaea dahurica.
Abstract A new phenylpropanoid allopyranoside (1) and a new indolinone alkaloid (2) were isolated from the rhizomes of Actaea dahurica (syn. Cimicifuga dahurica). The structures of those two compounds were deduced as cimicifugaside F (1) and 3E,11E-(3-methyl-2-butenylidene acid)-2-indolinone-1-O-β-d-glucopyranoside (2) by detailed analysis of their MS, 1D and 2D NMR data and comparison with literatures. Additionally, the isolates were evaluated for their inhibitory effects on the production of NO by LPS-stimulated RAW 264.7 macrophages. PMID: 32911990 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - September 11, 2020 Category: Biochemistry Authors: Ma SJ, Li HB, Shao JR, Pang QQ, Li T, Yao XS, Yu Y Tags: Nat Prod Res Source Type: research

Bioactive metabolites of hass and reed avocados targeting methicillin-resistant Staphylococcus aureus enterotoxin-like X via molecular modeling and cytotoxicity assessments.
Abstract The aim of this study is to estimate the nutritive values, metabolites of Hass and Reed Avocado cultivars and evaluate their antimicrobial and anticancer activities. Hass was rich in water soluble vitamins, iron and calcium while, Reed contains more fat soluble vitamins. Benzaldehyde and butyl phenol derivatives were the major volatile components identified by solid phase extraction in Hass and Reed, respectively. Naringenin and rutin were the major compounds identified in Hass and Reed by HPLC analysis respectively. Hass showed a promising antimicrobial activity, especially, against Methicillin-Resistant...
Source: Natural Product Research - September 11, 2020 Category: Biochemistry Authors: Younis IY, Hifnawy MS, El-Hawary SS, El Bishbishy MH, Elateek SY Tags: Nat Prod Res Source Type: research

Two new glycosides, farnesyl pentaglycoside and oleanane triglycoside from Lepisanthes rubiginosa, a mangrove plant collected from Thua Thien-Hue province, Vietnam.
Abstract Phytochemical investigation of the leaves of Lepisanthes rubiginosa led to the isolation of two new glycosides, lepisantheside A (1) and lepisantheside B (2), together with two known compounds acutoside A (3) and 3-O-[β-D-xylopyranosyl-(1→3)-β-D-glucopyranosyl-]-oleanolic acid (4). Their structures were elucidated by means of spectroscopic methods (HR-ESI-MS, 1D and 2D NMR), and by comparison with the reported data. The cytotoxicity of compounds 1-4 against four human cancer cell lines (KB, HepG2, SK-LU-1 and MCF7) was evaluated. Compound 4 exhibited significant activity with IC50 values of...
Source: Natural Product Research - September 9, 2020 Category: Biochemistry Authors: Tran LV, Pham Thi N, Nguyen Thi L, Van Tran C, Vo NTQ, Ho AN, Do VC, Tran VS, Tran TTP Tags: Nat Prod Res Source Type: research

Comparative study on phenolic, flavonoids and in  vitro antioxidant activity of wild edible plants from Loktak Lake wetland ecosystem under North East Indian Himalayan Region.
Comparative study on phenolic, flavonoids and in vitro antioxidant activity of wild edible plants from Loktak Lake wetland ecosystem under North East Indian Himalayan Region. Nat Prod Res. 2020 Sep 09;:1-4 Authors: Singh TS, Roy SS, Kshetri P, Ansari MA, Sharma SK, Verma MR, Singh IM, Prakash N, Kandpal B Abstract The present study investigates the antioxidant activity of 28 wild edible plants (WEPs) resources of Loktak Lake wetland ecosystem of Manipur, North East Indian Himalayan Region and their correlation with phenolics and flavonoids. Antioxidant activity was measured by DPPH, ABTS and FRAP...
Source: Natural Product Research - September 9, 2020 Category: Biochemistry Authors: Singh TS, Roy SS, Kshetri P, Ansari MA, Sharma SK, Verma MR, Singh IM, Prakash N, Kandpal B Tags: Nat Prod Res Source Type: research

Cytotoxicity and nitric oxide inhibitory activities of Xanthones isolated from Calophyllum hosei Ridl.
Abstract Previous studies on Calophyllum species have shown the existence of a wide variety of bioactive xanthones and coumarins. Phytochemical investigations carried out on the plant, Calophyllum hosei led to the isolation of eleven known xanthones, ananixanthone (1), 9-hydroxycalabaxanthone (2), dombakinaxanthone (3), thwaitesixanthone (4), caloxanthone B (5), trapezifolixanthone (6), β-mangostin (7), osajaxanthone (8), caloxanthone A (9), calozeyloxanthone (10) and rubraxanthone (11). The structures of these compounds were identified and elucidated using spectroscopic techniques such as NMR and MS. The cyt...
Source: Natural Product Research - September 9, 2020 Category: Biochemistry Authors: Daud S, Karunakaran T, Santhanam R, Nagaratnam SR, Jong VYM, Ee GCL Tags: Nat Prod Res Source Type: research

Chrysomutanin and related meroterpenoids from a DES mutant of the marine-derived fungus Penicillium chrysogenum S-3-25.
Abstract A new meroterpene, chrysomutanin (1), two new meroterpenoids (4 and 5) together with nine known ones were isolated from the diethyl sulphate (DES) mutant 3d10-01 of the marine-derived fungus Penicillium chrysogenum S-3-25. The structures of the isolated compounds were determined by their spectroscopic data, and the absolute configuration of 1 was determined by Rh2-induced electrical circular dichroism (ECD) analysis or by comparison of the measured ECD with that of the known compounds. The cytotoxic activity was preliminarily evaluated against five human cancer cell lines. HPLC-UV analysis showed that com...
Source: Natural Product Research - September 9, 2020 Category: Biochemistry Authors: Qiao H, Zhang SH, Dong Y, Yang Y, Xu R, Chen B, Wang Y, Zhu TJ, Cui CB, Zhang GG, Li CW Tags: Nat Prod Res Source Type: research

Estrogenic activities of compound GL-1, isolated from Ganoderma lucidum.
In this study, the estrogenic effect of GL-1, a component of the Ganoderma lucidum, was studied, and the possible mechanism was discussed preliminarily. The binding ability of GL-1 to estrogen receptor was calculated by computer aided simulation. The effects of GL-1 on the proliferation of estrogen sensitive estrogen receptor (ER) (+) MCF-7 cells and estrogen insensitive ER (-) MDA-MB-231 cells were detected by MTT method. The effects of GL-1 on the proliferation of estrogen-induced MCF-7 cells, and the effects of the estrogen receptor inhibitor ICI182780 on the proliferation of GL-1-induced MCF-7 cells were detected by MT...
Source: Natural Product Research - September 9, 2020 Category: Biochemistry Authors: Ye WY, Wang JZ, Deng GG, Dang YW, Liu HW, Chen G Tags: Nat Prod Res Source Type: research

Phytochemical, metabolic profiling and antiparasitic potential from Inga semialata leaves (Fabaceae).
Abstract Natural Products phytochemical provide a rich source for therapeutic discovery and has led to the development of many drugs. Thus, the aim of this study was to obtaining a metabolic profiling from ethanol extract of Inga semialata leaves (EEIS) selected by bioassay antimalarial and nematostatic and identify metabolites in mixture by co-injection experiments and NMR spectroscopy. The chemical composition of this species indicated a wide variety of aromatic acids (vanillic acid, 3,4,5-trimethoxy benzoic acid, gallic acid, methyl gallate, p-coumaric acid and ferulic acid), flavonoids (quercetin, myricetin-3-...
Source: Natural Product Research - September 9, 2020 Category: Biochemistry Authors: Lima NM, de Marqui SR, Andrade TJAS, Silva DHS Tags: Nat Prod Res Source Type: research

A pair of new isocoumarin enantiomers of Ludwigia hyssopifolia.
Abstract A pair of new isocoumarin derivative enantiomers, (S)-(-)-3-(3,3-dichloro-2-hydroxy-propyl)-4-chlorine-6,8-dihydroxy-isochromen-1- one (1a) and (R)-(+)-3-(3,3-dichloro-2-hydroxy-propyl)-4-chlorine-6,8-dihydroxy-isochromen-1- one (1 b), as well as seven known compounds (2-8) were isolated from Ludwigia hyssopifolia. Compounds 1a and 1 b were confirmed to be a pair of enantiomers by chiral HPLC-CD analysis, and the structure of compound 1 was determined by spectroscopic analyses including extensive 1 D (1H NMR, 13C NMR) and 2 D NMR spectra (COSY, HSQC and HMBC) and MS data. And t...
Source: Natural Product Research - September 3, 2020 Category: Biochemistry Authors: Zhang J, Liu C, Lv Y, Wei J, Li B, Liao G, Lu R, Yang X Tags: Nat Prod Res Source Type: research

Two new homoisoflavones from Portulaca oleracea L. and their activities.
Abstract Two new compounds, identified as 3-(2-hydroxybenzyl)-6,8-dimethoxy-4H-chromen-4-one (1), named oleracone J and 3-(2-hydroxybenzyl)-6,8-dimethoxychroman-4-one (2), named oleracone K, were isolated from Portulaca oleracea L., and the structures of them were determined by spectroscopy, including one-dimensional and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionisation time-of-flight mass spectrometry. The two compounds have scavenging activities in 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical quenching assay, with IC50 values of 18.34, 23.92 μM, and anticholinesterase...
Source: Natural Product Research - September 3, 2020 Category: Biochemistry Authors: Duan Y, Ying Z, Zhang M, Ying X, Yang G Tags: Nat Prod Res Source Type: research

Monitoring the antioxidant activity of an eco-friendly processed grape pomace along the storage.
Abstract The aims of this research are to compare and to monitor two conditions for preserving the total phenolic content (TPC) and the antioxidant activity (AOA) of grape pomace (GP) processed as powder and its corresponding extract at room and freezing temperature, respectively. The highest TPC and AOA were obtained in the GP extracted in a ratio 1:10 (w/v) with ethanol at 50% for 45 min at 50 °C. After 9 months of room temperature (RT) storage, the GP powder obtained a significantly higher AOA than the initial condition and the extract frozen-stored the same time. PMID: 32878452 [Pub...
Source: Natural Product Research - September 2, 2020 Category: Biochemistry Authors: Cisneros-Yupanqui M, Zagotto A, Alberton A, Lante A, Zagotto G, Ribaudo G, Rizzi C Tags: Nat Prod Res Source Type: research

New prenylated flavonoid and neuroprotective compounds from Tephrosia purpurea subsp. dunensis.
Abstract Continuation of the phytochemical investigation of the aerial parts of Tephrosia purpurea subsp. dunensis resulted in the isolation and structural elucidation of a new prenylated flavonoid demeapollinin (1), glabratephrinol (2) and a mixture (3) of tephroapollin G (3a) and epi-tephroapollin G (3b). The neuroprotective activity of compounds (1-3) besides the previously isolated compounds; dunensin (4), pseudosemiglabrin (6), glabratephrin (7), apollinin (5), kampferol 3, 7-O-α-L-dirhamnoside (8) and quercetin 3, 7-O-α-L-dirhamnoside (9) was examined. Molecular docking, acetylcholine esterase in...
Source: Natural Product Research - September 2, 2020 Category: Biochemistry Authors: Sallam A, Mira A, Sabry MA, Abdel-Halim OB, Gedara SR, Galala AA Tags: Nat Prod Res Source Type: research

Chemical constituent from the roots of Solanum melongena L. and their potential anti-inflammatory activity.
Abstract Three new compounds (1-3), were isolated from the ethanol extract of the roots of Solanum melongena L., together with twenty-seven knowns (4-30). On basis of their 1 D and 2 D NMR data, the chemical structures of islated compounds were elucidated combined with HR-MS and the relative values in literatures. In addition, the isolations were evaluated for the potential anti-inflammatory activity, by virtue of RAW 264.7 cells model induced by lipopolysaccharide (LPS)in vitro inhibitory activities on nitric oxide (NO) production. Compounds 12 and 21 showed moderate inhibition of NO production...
Source: Natural Product Research - September 2, 2020 Category: Biochemistry Authors: Liu Y, Yin X, Sun YP, Liu Y, Zhou YY, Pan J, Guan W, Yang BY, Kuang HX Tags: Nat Prod Res Source Type: research

Chemical constituents and dereplication study of Lessingianthus brevifolius (Less.) H.Rob. (Asteraceae) by UHPLC-HRMS and molecular networking.
o MH Abstract Chemical investigation of Lessingianthus brevifolius (Less.) H.Rob. aerial parts resulted in the isolation of the hirsutinolide-type sesquiterpene lactones piptocarphol, spicatolide D, piptocarphin D and 8α-acetoxy-10α-hydroxy-13-O-methylhirsutinolide, and also of a cadinanolide identified as 13-O-methylvernojalcanolide 8-O-acetate. Flavonoids, triterpenes and chlorogenic acids were also isolated. In addition, a dereplication study was carried out using UHPLC-HRMS and molecular networking, resulting in the identification of fifteen known compounds, being two sesquiterpene lactones and thi...
Source: Natural Product Research - September 1, 2020 Category: Biochemistry Authors: Arêas DRPC, Cabral MRP, Ramos AVG, Peixoto JLB, do Carmo MRB, Baldoqui DC, Porto C, Sarragiotto MH Tags: Nat Prod Res Source Type: research

Undescribed benzophenone and xanthones from cave-derived Streptomyces sp. CB09001.
Abstract A new benzophenone huanglongmycin (HLM) D (1) and two new monomeric xanthones huanglongmycin E (2) and F (3), together with four known aromatic polyketides aloesaponarin II (4) and the previously isolated huanglongmycin A-C (5-7) were obtained from cave-derived Streptomyces sp. CB09001. The structures of 1-3 were established based on 1D, 2D NMR and HRMS data. Compounds 1-7 may be biosynthesized by a type II huanglongmycin polyketide synthase based on gene inactivation of hlmG encoding KSɑ in hlm gene cluster and their plausible biosynthetic mechanism was proposed. PMID: 32873080 [PubMed - as supplie...
Source: Natural Product Research - September 1, 2020 Category: Biochemistry Authors: Jiang L, Xiang J, Zhu S, Tang D, Gong B, Pu H, Duan Y, Huang Y Tags: Nat Prod Res Source Type: research

Structures and biological evaluation of phenylpropanoid derivatives from Dendrobium Sonia.
Abstract Two new phenylpropanoid derivatives (1-2), together with eight known compounds (3-10) were isolated from the stems of Dendrobium sonia. The structures of these compounds were elucidated on the basis of spectroscopic analyses, including HRESIMS, 1 D and 2 D NMR experiments. All of the isolated compounds were tested for their Nitric Oxide (NO) Inhibitory Activities. The results of bioactive screening showed that compounds 2, 8, 9 and 10 exerted inhibitory effects on NO production with IC50 values in the range of 26.3 to 31.6 μM. Compound 8 and 9 exhibited stronger anti-inflammatory a...
Source: Natural Product Research - August 31, 2020 Category: Biochemistry Authors: Cai BX, Song LX, Hu HJ, Han ZZ, Zhou Y, Wang ZT, Yang L Tags: Nat Prod Res Source Type: research

Synthesis of the oxazolidinone fragment of thelepamide.
Abstract Thelepamide, an unique ketide-amino acid isolated from a marine annelid worm Thelepus crispus, has a unique oxazolidinone ring derived from cysteine, glycine and valine. Rareness in nature as well as promising bioactive possibility make the oxazolidinone ring an attractive synthetic target. The hydroxy oxazolidinone fragment of thelepamide was prepared by acid-catalysed N,O-acetal formation between a ketoamide and formaldehyde. Lactone-carbonyl selective isopropyl addition to an oxazilidine-dione under Grignard conditions also forms the target compound. PMID: 32865028 [PubMed - as supplied by publish...
Source: Natural Product Research - August 31, 2020 Category: Biochemistry Authors: Ashida N, Ida K, Koide Y, Vavricka CJ, Izumi M, Kiyota H Tags: Nat Prod Res Source Type: research

Guaianolides from Tanacetopsis karataviensis (Kovalevsk.) Kovalevsk.
Abstract In continuation of our phytochemical study on the aerial part of Tanacetopsis karataviensis (Kovalevsk.) Kovalevsk, three new guaiane-type sesquiterpene lactones were isolated namely karatanolide (1), 11,13β-dihydrokaratanolide (2) and 11,13α-dihydrokaratanolide (3), in addition to the two known sesquiterpene lactones 1β,10α-dihydroxyarglabin (4) and artefin (5). The structures of the isolated sesquiterpene lactones were elucidated by IR and NMR spectroscopy. Single crystal X-ray diffraction allowed to unambiguously confirm the structure of the isolated sesquiterpene lactones. Quantu...
Source: Natural Product Research - August 31, 2020 Category: Biochemistry Authors: Dusmatova DE, Bobakulov KМ, Turgunov KK, Мukhamatkhanova RF, Uzbekov VV, Gildenast H, Englert U, Sham'yanov ID, Tashkhojaev B, Bruskov VP, Аbdullaev ND Tags: Nat Prod Res Source Type: research

In vitro antioxidant and antimicrobial activity of Cannabis sativa L. cv 'Futura 75' essential oil.
Abstract In the present work, Cannabis sativa L. cv Futura 75 inflorescences, cultivated in the Abruzzo territory, were characterized for their volatile fraction through SPME-GC-MS. In addition, the essential oil extracted from these inflorescences was investigated for the antioxidant potentialities and for the terpenic profile. The antibacterial activity of hemp essential oil (HEO) against some pathogenic and spoilage microorganisms isolated from food was also evaluated by determining the minimal inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). The results showed significant antiox...
Source: Natural Product Research - August 31, 2020 Category: Biochemistry Authors: Pellegrini M, Palmieri S, Ricci A, Serio A, Paparella A, Lo Sterzo C Tags: Nat Prod Res Source Type: research

Antifungal activity and chemical composition of the essential oil from the aerial parts of two new Teucrium capitatum L. chemotypes from Sardinia Island, Italy.
xia A Abstract The chemical composition of two populations of Teucrium capitatum L. one from the coastline and the other one from the mountainous area of Sardinia (Italy) was assessed. Two chemotypes were identified: limonene/α-pinene/(E)-nerolidol chemotype predominant in the coastline, and limonene/α-pinene/α-trans-bergamotene/humulene epoxide II chemotype common in plants growing in the mountainous area. In addition, our results showed that the sample growing in the coastline had a more promising antifungal activity. Furthermore, this sample was highly effective in inhibiting C. albicans germ ...
Source: Natural Product Research - August 28, 2020 Category: Biochemistry Authors: Maccioni A, Falconieri D, Porcedda S, Piras A, Gonçalves MJ, Alves-Silva JM, Salgueiro L, Maxia A Tags: Nat Prod Res Source Type: research

Chemical composition of Blumea balsamifera and Magnolia sieboldii essential oils and prevention of UV-B radiation-induced skin photoaging.
In this study, the chemical compositions of BBEOs and MSEOs are firstly determined by GC-MS analysis, and then their anti-photoaging is evaluated via an ultraviolet radiation (UV-B) induced mice skin-injury model. A total of 35 and 33 components are identified from BBEOs and MSEOs, and their dominant compositions are caryophyllene (18.54%) and borneol (18.33%) in BBEOs, and β-elemene (29.10%), γ-terpinene (17.01%) and (E)-β-ocymene (11.69%) in MSEOs. According to the skin injury model, the application of BBEOs and MSEOs to mice skin can effectively inhibit skin photoaging by down-regulating the expression o...
Source: Natural Product Research - August 28, 2020 Category: Biochemistry Authors: Zhang B, Tang M, Zhang W, Zhangb C, Ai Y, Liang X, Shi Y, Chen Y, Zhang L, He T Tags: Nat Prod Res Source Type: research

Phytochemical profile, antimicrobial and antioxidant activities of essential oil extracted from Ecuadorian species Piper ecuadorense sodiro.
rez J Abstract In the present research, the essential oil from Piper ecuadorense was analysed by GC/MS and GC/FID techniques. A total of forty-four chemical compounds were identified which represent 98.65% of the essential oil composition. The main compounds were bicyclogermacrene (12.98%), 3-thujopsanone (11.59%), α-phellandrene (6.89%), (E)-nerolidol (6.88%), δ-elemene (6.83%) and shyobunol (5.79%). The essential oil from P. ecuadorense exerted a strong activity against Gram-positive bacterium Staphylococcus aureus (ATCC 25923) with an MIC of 250 μg/mL, and a very strong activity against Tr...
Source: Natural Product Research - August 27, 2020 Category: Biochemistry Authors: Valarezo E, Flores-Maza P, Cartuche L, Ojeda-Riascos S, Ramírez J Tags: Nat Prod Res Source Type: research

New iridoid glucosides from the roots of Rothmannia wittii (Craib) Bremek.
Abstract Phytochemical investigation of the roots of Rothmannia wittii led to the isolation of three new iridoid glucosides, named rothmanniosides A-C (1-3), and nine known compounds (4-12). Their structures, including their absolute configurations, were elucidated by thorough analysis of mass spectrometric and NMR spectroscopic data, together with CD calculations. Compounds 4 and 11 are reported from the Rubiaceae family for the first time. PMID: 32851863 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - August 27, 2020 Category: Biochemistry Authors: Wisetsai A, Schevenels FT, Faksri K, Tontapha S, Amornkitbamrung V, Lekphrom R Tags: Nat Prod Res Source Type: research

A new depsidone derivative from mangrove endophytic fungus Aspergillus sp. GXNU-A9.
Abstract A new tetracyclic depsidone derivative, guanxidone A (1), together with three known metabolites 2-4, was isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-A9. The structure of compound 1 was established by HR-ESI-MS, 1 D and 2 D NMR data, as well as by comparison with literature data. Compounds 1-4 were evaluated for their anti-inflammatory effects on the production of the nitric oxide (NO), and compound 1 significantly reduced the production of NO in lipopolysaccharide (LPS)-stimulated cells with IC50 value of 8.22 µM. PMID: 32851874 [PubMed - as supplied b...
Source: Natural Product Research - August 27, 2020 Category: Biochemistry Authors: Hao L, Zhou D, Qin X, Zhang W, Yang R, Li J, Huang X Tags: Nat Prod Res Source Type: research

Insecticidal activity of the essential oil of Perovskia artemisioides Boiss.
Abstract This work reports the phytochemical profile and insecticidal properties of Perovskia artemisioides Boiss essential oil (PAEO) collected in Baluchestan, Iran. Totally, twenty-six substances were identified with 1,8-cineole (25.81%), geranyl acetate (13.00%) and linalool (10.21%) as dominant chemical metabolites by GC-MS analysis. PAEO possessed fumigant toxicity against various growth stages of Phthorimaea operculella. P. operculella adults showed considerable sensitivity (LC50 = 0.58 µL/L air) in comparison to eggs (LC50 = 5.87 µL/L air) and neonate larvae (LC50 = 1.23 &mi...
Source: Natural Product Research - August 26, 2020 Category: Biochemistry Authors: Sadeghi Z, Alizadeh Z, Khorrami F, Norouzi S, Moridi Farimani M Tags: Nat Prod Res Source Type: research

How to ensure water supply to natural plants? The contribution of sensor technology.
Abstract Plants contribute to increase our green space and to produce natural compounds and substances to be applied to many fields of human activity, from foods to pharmaceuticals, from cosmetics to environment. Sensor technology can contribute to ensure living conditions to plants starting from the monitoring of water mobility within soil. A sensor based on a gypsum crystal is here proposed and validated to check mobility of water in different kinds of soil. PMID: 32840118 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Campanella L, Jiofack Tenkeu HA, Castrucci M, Dell'Aglio E Tags: Nat Prod Res Source Type: research

Jabuticaba [Plinia peruviana (Poir.) Govaerts]: a Brazilian fruit with a promising application against itraconazole-susceptible and -resistant Sporothrix brasiliensis.
Abstract Hydroalcoholic extract from Jabuticaba peels was evaluated for the chemical profile, antioxidant potential, cytotoxicity, and anti-Sporothrix brasiliensis activities against both dimorphic phases. Higher phenolic content (14.91 ± 0.97) compared to flavonoid (2.05 ± 1.00) associated with the ellagic acid (1.93 ± 0.03; LC-MS), and a good scavenging ability against ABST and DPPH radicals was noted. On MDBK cells, elevated cell viability (>90%) was demonstrated between 0.39 and 0.097 mg/ml (MTT assay). Mycelial (CLSI M38-A2) and yeast (C...
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Waller SB, Peter CM, Hoffmann JF, Cleff MB, Faria de RO, Zani JL Tags: Nat Prod Res Source Type: research

Tectonaquinones A, B and C: three new naphthoquinone derivatives from the heartwood of Tectona grandis.
Abstract Chemical investigation of the chloroform extract of heartwood of Tectona grandis L. f. led to the isolation of three new naphthoquinone derivatives, tectonaquinones A (1), B (2) and C (3), along with six known compounds: barleriaquinone-I (4), tectoquinone (5), tecomaquinone I (6), lapachol (7), obtusifolin (8) and 2-hydroxy-3-methyl anthraquinone (9). The structures of the new compounds were elucidated by spectroscopic methods including 2 D NMR experiments. Tectonaquinone B is the first natural compound that has a hexa-cyclic dinaphthofuran-dione scaffold. Tectonaquinone C has a bicyclic acetal mo...
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Vyas P, Wadhwani BD, Khandelwal P, Araya H, Fujimoto Y Tags: Nat Prod Res Source Type: research

Antioxidant role of morusin and mulberrofuran B in ethanol extract of Morus alba roots.
Abstract The white mulberry, Morus alba, is distributed worldwide and known for its antioxidant properties. Ethanol extract of six varieties of M. alba roots were studied (IZ 13/6, IZ 40, IZ 56/4, IZ 64, Indonesia and Tigreada). From variety IZ 40, two secondary metabolites were isolated and unambiguously identified by 2 D NMR experiments as morusin and mulberrofuran B. These were quantified in the varieties by liquid chromatography, recording 5.27-16.74% for the first, and 0.54-3.55% for the latter. Mulberrofuran B presented higher activity than morusin by phosphomolybdenum (1531.33 ± ...
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Martins BA, Sande D, Solares MD, Takahashi JA Tags: Nat Prod Res Source Type: research

A chalcone (Pongamol) and phytoconstituents of Tephrosia purpurea.
Abstract Tephrosia purpurea stem extract fractions shows more amount of Cyclohexane, 1-ethenyl-1-methyl-2,4-bis(1-methylethenyl)-, (1α,2β,4β)- (62.32%). Secondary metabolites contents were higher in stem than root of T. purpurea. It is the first time a chalcone (Pongamol) was crystallised from the column chromatography fraction of T. purpurea stem extract identified by using FT-IR and XRD. Quantitative analysis of T. purpurea stem and root reveals that total saponins, tannins and phenols (mg/g plant powder) contents were higher in the former than the latter part of the plant, respectively. PMI...
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Sahayaraj K, Kombiah P, Rathi JAM Tags: Nat Prod Res Source Type: research

Synergistic activity of Pelargonium capitatum and Cymbopogon martini essential oils against C. albicans.
In conclusion, it is possible to hypothesize that PCEO can be used in combination with fluconazole or CMEO. Further studies are in due course to confirm these results. PMID: 32840389 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Angiolella L Tags: Nat Prod Res Source Type: research

Two new diterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata.
Abstract Two new diterpenoids, penicichrysogene A (1) and penicichrysogene B (2), were isolated from the solid substrate fermentation cultures of Penicillium chrysogenum MT-12, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Their structures were elucidated on the basis of extensive spectroscopic and spectrometric data (1D and 2D NMR, UV, IR, and HRESIMS). The absolute configurations of 1 and 2 were assigned on the basis of experimental and calculated electronic circular dichroism spectra. Compound 1 exhibited inhibitory activity on ATP release of thrombin-activated platelets with IC50 ...
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Qi B, Jia F, Luo Y, Ding N, Li S, Shi F, Hai Y, Wang L, Zhu ZX, Liu X, Tu P, Shi SP Tags: Nat Prod Res Source Type: research

Biological properties of functional flavoring produced by enzymatic esterification of citronellol and geraniol present in Cymbopogon winterianus essential oil.
Abstract The chemical composition and biological properties of citronella essential oil were modified by enzymatic esterification reaction of the major monoterpenic alcohols with cinnamic acid. The almost complete conversion of geraniol and citronellol present in the citronella (Cymbopogon winterianus) essential oil, into geranyl (99%) and citronellyl (98%) cinnamates was obtained after 48 hours of reaction using a molar ratio of 3:1 (cinnamic acid/alcohol), lipase concentration (Novozym 435) of 15% (w/w) and 70 °C. The esterified oil showed higher antimicrobial activity against Staphylococcus au...
Source: Natural Product Research - August 25, 2020 Category: Biochemistry Authors: Staudt A, Duarte PF, Amaral BPD, Peixoto Andrade BCO, Simas NK, Correa Ramos Leal I, Sangenito LS, Santos ALSD, de Oliveira D, Junges A, Cansian RL, Paroul N Tags: Nat Prod Res Source Type: research

Supercritical extraction of volatile and fixed oils from Petroselinum crispum L. seeds: chemical composition and biological activity.
Abstract The supercritical fluid extraction (SFE) of volatile and fixed oil from milled parsley (Petroselinum crispum L.) seeds, using CO2 as solvent, is presented in this study. Extraction experiments were carried out in two steps: at pressures of (90 or 300) bar and temperature of 40 °C. The first extraction step, performed at 90 bar, produced a volatile fraction mainly formed by apiole (82.1%) and myristicin (11.4%). The volatile oil yield was 2.6% by weight of the charge. The second extraction step, carried out at 300 bar produced a fixed oil at a yield of 0.4% by weight. The most represented...
Source: Natural Product Research - August 21, 2020 Category: Biochemistry Authors: Piras A, Porcedda S, Falconieri D, Fais A, Era B, Carta G, Rosa A Tags: Nat Prod Res Source Type: research