Prenylated dihydroflavones from the root barks of < em > Morus alba < /em >
Nat Prod Res. 2023 Mar 16:1-8. doi: 10.1080/14786419.2023.2189710. Online ahead of print.ABSTRACTThree new prenylated dihydroflavones, moralbaflavones A-C (1-3), together with four known ones (4a/4b, 5, and 6) were isolated from the root barks of Morus alba L. Their structures including the absolute configurations were determined by the analysis of HRMS, NMR, and ECD data. The neuroprotective properties of these prenylated dihydroflavones were screened at the concentration of 10 µM in the sodium nitroprusside-induced rat pheochromocytoma PC-12 cells, and the results showed moralbaflavone C (3) possessed significant neurop...
Source: Natural Product Research - March 17, 2023 Category: Biochemistry Authors: Jun-Yu Zhu Han-Zhuang Weng Di-Kai Tang Jin-Chen Long Zhuo-Ya Tang Ye Chen Sheng Yin Gui-Hua Tang Source Type: research
Isolation, characterization, and evaluation of anxiolytic bioactive compounds from the seed of < em > Vigna radiata (L.) < /em > R. Wilczek in mice
This study validates the ethnopharmacological use of V. radiata seeds in the management of anxiety disorders.PMID:36929717 | DOI:10.1080/14786419.2023.2189709 (Source: Natural Product Research)
Source: Natural Product Research - March 17, 2023 Category: Biochemistry Authors: Sonali V Uppalwar Vandana Garg Shrikant Joshi Rohit Dutt Source Type: research
Prenylated dihydroflavones from the root barks of < em > Morus alba < /em >
Nat Prod Res. 2023 Mar 16:1-8. doi: 10.1080/14786419.2023.2189710. Online ahead of print.ABSTRACTThree new prenylated dihydroflavones, moralbaflavones A-C (1-3), together with four known ones (4a/4b, 5, and 6) were isolated from the root barks of Morus alba L. Their structures including the absolute configurations were determined by the analysis of HRMS, NMR, and ECD data. The neuroprotective properties of these prenylated dihydroflavones were screened at the concentration of 10 µM in the sodium nitroprusside-induced rat pheochromocytoma PC-12 cells, and the results showed moralbaflavone C (3) possessed significant neurop...
Source: Natural Product Research - March 17, 2023 Category: Biochemistry Authors: Jun-Yu Zhu Han-Zhuang Weng Di-Kai Tang Jin-Chen Long Zhuo-Ya Tang Ye Chen Sheng Yin Gui-Hua Tang Source Type: research
Isolation, characterization, and evaluation of anxiolytic bioactive compounds from the seed of < em > Vigna radiata (L.) < /em > R. Wilczek in mice
This study validates the ethnopharmacological use of V. radiata seeds in the management of anxiety disorders.PMID:36929717 | DOI:10.1080/14786419.2023.2189709 (Source: Natural Product Research)
Source: Natural Product Research - March 17, 2023 Category: Biochemistry Authors: Sonali V Uppalwar Vandana Garg Shrikant Joshi Rohit Dutt Source Type: research
Stigmastane-type steroid saponins from the leaves of < em > Vernonia amygdalina < /em > and their < em > α < /em > -glucosidase and xanthine oxidase inhibitory activities
Nat Prod Res. 2023 Mar 16:1-6. doi: 10.1080/14786419.2023.2188589. Online ahead of print.ABSTRACTTwo new vernonioside K (1) and vernonioside L (2) and four known Δ7,9(11) stigmastane-type steroidal saponins-vernonioside B2 (3), vernoniacum B (4), vernonioside B1 (5), and vernoamyoside A (6)-were isolated from the leaves of Vernonia amygdalina. Their structures were determined by comprehensive spectroscopic analysis with one-dimensional nuclear magnetic resonance, two-dimensional nuclear magnetic resonance, and high-resolution mass spectrometry. All isolated compounds (1-6) were evaluated to determine their inhibitory effe...
Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: PCong Pham Van Hieu Ngo Van Minh Bui Quang Nam Duong Thanh Dan Nguyen Van Tuan Do Thanh Ngoc Tran Minh Hien Nguyen Thi Thu Trung Nguyen Quang Thi Thao Do Loan Pham Thanh Hien Do Thi Thu Anh Hoang Le Tuan Source Type: research
Chemical constituents from < em > Trillium camschatcense < /em >
Nat Prod Res. 2023 Mar 16:1-10. doi: 10.1080/14786419.2023.2188211. Online ahead of print.ABSTRACTTwo undescribed polyacetylated 18-norspirostanol saponins, trilliumosides J (1) and 21-deoxyepitrillenoside C (2), a novel resveratrol aneuploid, 3a,3b-dimethoxyhopeachinol B (3) along with four known steroidal saponins (4-7), were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium camschatcense. The structures of isolated compounds were elucidated by spectroscopic analysis and chemical degradation. Compounds 1,3 and 4 had potential cytotoxic activity against MCF-7, with IC50 values 86.38 ± 2.59 μM, 56....
Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: Jianwei Xie Kunjun Wang Xiaoxu Gao Anhua Wang Gaosheng Hu Ting Yan Jingming Jia Source Type: research
Chemical prospection and antioxidant activity of < em > Humiria balsamifera < /em > (Aubl.) A. St. Hil. < em > AND Hymenaea courbaril < /em > L
The objective of this study was to conduct chemical analyses of bioactive compounds found in the bark and leaves of Humiria balsamifera (Aubl.) A. St. Hil. and Hymenaea courbaril L. Chemical screening was performed to detect the presence of secondary metabolites. Quantification of the concentrations of phenolic compounds, anthocyanins, flavonoids, and antioxidants was performed by ultraviolet spectrophotometry through recommended methodologies. Extracts of the leaves of Humiria balsamifera (Aubl.) A. St. Hil. were found to have high concentrations of flobabénic tannins. Tannins, flavonoids, flavonols, flavonones, flavanon...
Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: Jhuliana Monteiro de Matos Andressa Rose Castro Costa Marciel Nascimento Justino Marcos Bispo Pinheiro Camara Osmar Luis Silva Vasconcelos J C Marques Clenilma Marques Brand ão Georgiana Eurides de Carvalho Marques Source Type: research
Stigmastane-type steroid saponins from the leaves of < em > Vernonia amygdalina < /em > and their < em > α < /em > -glucosidase and xanthine oxidase inhibitory activities
Nat Prod Res. 2023 Mar 16:1-6. doi: 10.1080/14786419.2023.2188589. Online ahead of print.ABSTRACTTwo new vernonioside K (1) and vernonioside L (2) and four known Δ7,9(11) stigmastane-type steroidal saponins-vernonioside B2 (3), vernoniacum B (4), vernonioside B1 (5), and vernoamyoside A (6)-were isolated from the leaves of Vernonia amygdalina. Their structures were determined by comprehensive spectroscopic analysis with one-dimensional nuclear magnetic resonance, two-dimensional nuclear magnetic resonance, and high-resolution mass spectrometry. All isolated compounds (1-6) were evaluated to determine their inhibitory effe...
Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: PCong Pham Van Hieu Ngo Van Minh Bui Quang Nam Duong Thanh Dan Nguyen Van Tuan Do Thanh Ngoc Tran Minh Hien Nguyen Thi Thu Trung Nguyen Quang Thi Thao Do Loan Pham Thanh Hien Do Thi Thu Anh Hoang Le Tuan Source Type: research
Chemical constituents from < em > Trillium camschatcense < /em >
Nat Prod Res. 2023 Mar 16:1-10. doi: 10.1080/14786419.2023.2188211. Online ahead of print.ABSTRACTTwo undescribed polyacetylated 18-norspirostanol saponins, trilliumosides J (1) and 21-deoxyepitrillenoside C (2), a novel resveratrol aneuploid, 3a,3b-dimethoxyhopeachinol B (3) along with four known steroidal saponins (4-7), were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium camschatcense. The structures of isolated compounds were elucidated by spectroscopic analysis and chemical degradation. Compounds 1,3 and 4 had potential cytotoxic activity against MCF-7, with IC50 values 86.38 ± 2.59 μM, 56....
Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: Jianwei Xie Kunjun Wang Xiaoxu Gao Anhua Wang Gaosheng Hu Ting Yan Jingming Jia Source Type: research
Chemical prospection and antioxidant activity of < em > Humiria balsamifera < /em > (Aubl.) A. St. Hil. < em > AND Hymenaea courbaril < /em > L
The objective of this study was to conduct chemical analyses of bioactive compounds found in the bark and leaves of Humiria balsamifera (Aubl.) A. St. Hil. and Hymenaea courbaril L. Chemical screening was performed to detect the presence of secondary metabolites. Quantification of the concentrations of phenolic compounds, anthocyanins, flavonoids, and antioxidants was performed by ultraviolet spectrophotometry through recommended methodologies. Extracts of the leaves of Humiria balsamifera (Aubl.) A. St. Hil. were found to have high concentrations of flobabénic tannins. Tannins, flavonoids, flavonols, flavonones, flavanon...
Source: Natural Product Research - March 16, 2023 Category: Biochemistry Authors: Jhuliana Monteiro de Matos Andressa Rose Castro Costa Marciel Nascimento Justino Marcos Bispo Pinheiro Camara Osmar Luis Silva Vasconcelos J C Marques Clenilma Marques Brand ão Georgiana Eurides de Carvalho Marques Source Type: research
Talarostatin, a vermistatin derivative from the soil-derived fungus < em > Talaromyces thailandensis < /em > PSU-SPSF059
Nat Prod Res. 2023 Mar 15:1-8. doi: 10.1080/14786419.2023.2188209. Online ahead of print.ABSTRACTThe soil-derived fungus Talaromyces thailandensis PSU-SPSF059 produced one new vermistatin derivative, talarostatin, and seven known compounds including two vermistatins, two chrodrimanins, two diphenyl ethers and one penicillide derivative. Extensive spectroscopic analysis was performed to identify their structures. The absolute configuration of talarostatin was determined by comparing the experimental and calculated electronic circular dichroism data. The antimicrobial and cytotoxic activities of the isolated secondary metabo...
Source: Natural Product Research - March 15, 2023 Category: Biochemistry Authors: Baiq Nila Sari Ningsih Vatcharin Rukachaisirikul Souwalak Phongpaichit Chatchai Muanprasat Sita Preedanon Jariya Sakayaroj Ratchadaree Intayot Siriporn Jungsuttiwong Source Type: research
Sinoflavonoids NJ and NK, anti-inflammatory prenylated flavonoids from the fruits of < em > Podophyllum hexandrum < /em > Royle
Nat Prod Res. 2023 Mar 13:1-5. doi: 10.1080/14786419.2023.2188590. Online ahead of print.ABSTRACTTwo new prenylated flavonoids named sinoflavonoids NJ and NK (1-2), along with ten known compounds were isolated from the fruits of Podophyllum hexandrum Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ (1) with an unusual 5,11-dioxabenzo[b]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested with LPS-induced RAW 264.7 mouse macrophages model for their anti-inflammatory activity. Sinoflavonoid NJ (1) showed the most po...
Source: Natural Product Research - March 14, 2023 Category: Biochemistry Authors: Junyang Wang Han Li Yanhui Li Aiping Yang Sheng Bao Yuntian Zhang Qing Du Zongping Zheng Xiachang Wang Source Type: research
Sinoflavonoids NJ and NK, anti-inflammatory prenylated flavonoids from the fruits of < em > Podophyllum hexandrum < /em > Royle
Nat Prod Res. 2023 Mar 13:1-5. doi: 10.1080/14786419.2023.2188590. Online ahead of print.ABSTRACTTwo new prenylated flavonoids named sinoflavonoids NJ and NK (1-2), along with ten known compounds were isolated from the fruits of Podophyllum hexandrum Royle. The chemical structures were determined through NMR spectroscopic data and MS analysis. Sinoflavonoid NJ (1) with an unusual 5,11-dioxabenzo[b]fluoren-10-one skeleton was firstly reported from Berberidaceae. The isolated flavonoids were tested with LPS-induced RAW 264.7 mouse macrophages model for their anti-inflammatory activity. Sinoflavonoid NJ (1) showed the most po...
Source: Natural Product Research - March 14, 2023 Category: Biochemistry Authors: Junyang Wang Han Li Yanhui Li Aiping Yang Sheng Bao Yuntian Zhang Qing Du Zongping Zheng Xiachang Wang Source Type: research
HS-SPME-GC-MS determination of the scent of < em > Anacamptis < /em > taxa (fam. Orchidaceae) from Basilicata (Southern Italy)
Nat Prod Res. 2023 Mar 12:1-5. doi: 10.1080/14786419.2023.2187797. Online ahead of print.ABSTRACTThe scent of Anacamptis species has been analyzed by using HS-SPME-GC-MS. The sample was collected in Basilicata (Southern Italy). Every species showed a different composition of the scent in the analyses we performed. 1,2,4-Trimethoxybenzene and methyl 4-mehoxybenzoate were the main components of that of Anacamptis coriophora subsp. fragrans. The scent of Anacamptis laxiflora was due to the presence of caryophyllene. Linear hydrocarbons but also decanal were components of the scent of Anacamptis pyramidalis. Eucalyptol was fou...
Source: Natural Product Research - March 13, 2023 Category: Biochemistry Authors: Maurizio D'Auria Lucia Emanuele Richard Lorenz Marisabel Mecca Rocco Racioppi Vito Antonio Romano Licia Viggiani Source Type: research
Two new serratene triterpenes from club moss cultivars
Nat Prod Res. 2023 Mar 12:1-9. doi: 10.1080/14786419.2023.2188587. Online ahead of print.ABSTRACTTwo new serratene triterpenes, 14α,21β-dihydroxyserrat-3β-yl acetate and 3α,21β-dihydroxyserrat-14-en-23-oic acid, together with eight known compounds were isolated from two club moss cultivars, Phlegmariurus carinatus (Desv.) Ching and Phlegmariurus nummulariifolius (Blume) Ching. 14α,21β-Ddihydroxyserrat-3β-yl acetate (1) was isolated from P. carinatus, and 3α,21β-dihydroxyserrat-14-en-23-oic acid (2), an undescribed carboxylic group at C-23 position of the serratene triterpenoids, was isolated from P. nummulariifol...
Source: Natural Product Research - March 13, 2023 Category: Biochemistry Authors: Wachirasak Thaisaeng Wanlaya Thamnarak Somsak Ruchirawat Kittipong Chainok Nopporn Thasana Source Type: research
