The composition of the aroma of Serapias orchids in Basilicata (Southern Italy).
Abstract The SPME-GC-MS analysis of the aroma components of Serapias cordigera, Serapias cordigera subsp. lucana, Serapias vomeracea, Serapias lingua, and Serapias parviflora were reported. The relevant components of the scent of Serapias cordigera were α-amorphene, ethyl oleate, heneicosane, heptadecane, 2-heptadecanone, ethyl elaidate, pentadecane, octadecane, farnesylacetaldehyde, nonadecane, and ethyl stearate. Serapias cordigera subsp. lucana gave α-amorphene, pentadecane, propyl undecanoate, heptadecane, ethyl elaidate and oleate, ethyl stearate, and 8-heptadecene. Serapias vomeracea showed penta...
Source: Natural Product Research - January 20, 2020 Category: Biochemistry Authors: D'Auria M, Lorenz R, Mecca M, Racioppi R, Romano VA Tags: Nat Prod Res Source Type: research

Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl.
Bioactive constituents from Manilkara obovata (Sabine & G.Don) J.H.Hemsl. Nat Prod Res. 2020 Jan 20;:1-10 Authors: Akosung E, Kenmogne SB, Lobe Songue J, Longue Ekon JP, Lateef M, Ngeufa Happi E, Langat MK, Tabekoueng GB, Toze FAA, Stammler HG, Ndjakou Lenta B, Wansi JD, Sewald N, Ali MS, Kamdem Waffo AF Abstract The phytochemical investigation of the methanolic extracts of roots, stem bark, leaves and twigs of Manilkara obovata has led to the isolation of one new friedelane triterpene, lacefriedelic acid or 3β,23-dihydroxy D:A-friedooleanan-28-oic acid (1) and one new prenylated xanthone, la...
Source: Natural Product Research - January 20, 2020 Category: Biochemistry Authors: Akosung E, Kenmogne SB, Lobe Songue J, Longue Ekon JP, Lateef M, Ngeufa Happi E, Langat MK, Tabekoueng GB, Toze FAA, Stammler HG, Ndjakou Lenta B, Wansi JD, Sewald N, Ali MS, Kamdem Waffo AF Tags: Nat Prod Res Source Type: research

Two new alkaloids from the sepals of Solanum melongena L.
Abstract Two new alkaloids named Melongenamides H-I (1-2), together with twenty-one known compounds (3-23), were isolated from the 70% ethanol extract of the sepals of Solanum melongena L. The structures of all isolated compounds were determined by 1D and 2D NMR spectra and by comparing their spectroscopic and physical data with values from the published literatures. All the isolated compounds were evaluated the cytotoxicity against three human canner lines (Hela, Ishikawa and MGC-803) by CCK8 assay. PMID: 31951465 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - January 17, 2020 Category: Biochemistry Authors: Zhao DY, Liu Y, Yin X, Li XM, Pan J, Guan W, Yang BY, Kuang HX Tags: Nat Prod Res Source Type: research

A new alkynol compound from Platycodins folium and its cytotoxicity.
Abstract A new alkynol, platycodynol (1), identified as 2, 3, 9, 13, 14-pentahydroxy-4, 6-tetradecadiyne, along with six known compounds (2-7) were obtained from Platycodins folium for the first time. Their structures were elucidated with infrared (IR), ultraviolet (UV), 1D and 2D nuclear magnetic resonance (NMR) spectroscopic analysis as well as by high resolution electrospray ionization mass spectroscopy (HRESIMS). Platycodynol showed cytotoxicity against S180, A549 and SPC-A-1 cancer cells but no cytotoxicity against normal cells NCTC1469 and HL-7702 by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium brom...
Source: Natural Product Research - January 17, 2020 Category: Biochemistry Authors: Wang C, Dong Q, Wu F, Li Z, Li P, Liu J, Wang F Tags: Nat Prod Res Source Type: research

Shoot aqueous extract of Manihot esculenta Crantz (cassava) acts as a protective agent against paracetamol-induced liver injury.
Abstract Manihot esculenta Crantz (Euphorbiaceae), known as cassava, is a widely cultivated plant, considered one of the main sources of food in the tropical and subtropical regions of Africa and Asia. The aim of the present study was the evaluation of the antioxidant and anti-inflammatory effects of cassava shoot aqueous extract (CSAE) on liver injury induced by paracetamol and investigation of its effect on hyperhomocysteinemia. CSAE was administered to male albino rats classified into seven groups: control, treated, and prophylactic groups. A significant reduction in liver enzymes, malondialdehyde, and homocyst...
Source: Natural Product Research - January 17, 2020 Category: Biochemistry Authors: Elshamy AI, El Gendy AEG, Farrag ARH, Hussein J, Mohamed NA, El-Kashak WA, Nardoni S, Mancianti F, De Leo M, Pistelli L Tags: Nat Prod Res Source Type: research

A new ergostane derivative from the leaves of Heynea trijuga Roxburgh.
Abstract During the course of searching for structurally interesting and bioactive compounds, a further chemical investigation of the leaves of Heynea trijuga Roxburgh was performed, which led to the isolation of a new ergostane derivative, named 3β, 4β, 20S-trihydroxyergosta-5, 24(28)-dien-16-one (1), together with five known sterides (3β, 23S)-ergosta-5, 24(28)-diene-3, 23-diol (2), ergosta-5, 24(28)-diene-3β-diol (3), stigmast-5-ene-3β, 7α-diol (4), sitoindoside I (5) and stigmast-3β, 5α, 6β-triol (6). The structure of the new compound was elucidated using a combin...
Source: Natural Product Research - January 17, 2020 Category: Biochemistry Authors: Liu SB, Cui Z, Chen HQ, Wang H, Dong WH, Cai CH, Mei WL, Dai HF Tags: Nat Prod Res Source Type: research

Secondary metabolites from cultures of the ant pathogenic fungus Ophiocordyceps irangiensis BCC 2728.
Abstract Five new compounds, iranginins A-E (1-5), together with sixteen known compounds were isolated from the insect pathogenic fungus Ophiocordyceps irangiensis BCC 2728. The structures and the absolute configurations of the new compounds were established by spectroscopic analyses, the application of modified Mosher's method (for 2), ECD calculation (for 5), and X-ray crystallographic analysis (for 4). LL-Z1640-5 and mucorisocoumarin C were active against Mycobacterium tuberculosis (MIC 41.7 and 85.0 µM, respectively), while peyroisocoumarin D exhibited cytotoxic activity (IC50 65.6 µM...
Source: Natural Product Research - January 14, 2020 Category: Biochemistry Authors: Saepua S, Kornsakulkarn J, Auncharoen P, Rachtawee P, Kongthong S, Boonyuen N, Harding DJ, Nehira T, Thongpanchang T, Thongpanchang C Tags: Nat Prod Res Source Type: research

Chemical constituents of Trillium tschonoskii Maxim.
Abstract A new fatty acid-spirostan steroid glycoside ester, a new cholestane glycoside and a new stilbene trimer, along with three known steroidal saponins, were isolated from the 70% EtOH extract of the roots and rhizomes of Trillium tschonoskii Maxim. The structure of isolated compounds was elucidated by spectroscopic analysis. Compound 1-6 were assessed for their cytotoxicity against cancer cell lines (MCF-7, HCT-116, DU-145, SGC-7901, MCF-7/ADR, K562/ADR), and the result showed that compound 4 was highly toxic to six human tumor cell lines. PMID: 31928348 [PubMed - as supplied by publisher] (Source: Natu...
Source: Natural Product Research - January 13, 2020 Category: Biochemistry Authors: Yan T, Wang A, Hu G, Jia J Tags: Nat Prod Res Source Type: research

A new sesquiterpenoid and further natural products from Taraxacum portentosum Kirschner & Štěpánek, an endangered species.
A new sesquiterpenoid and further natural products from Taraxacum portentosum Kirschner & Štěpánek, an endangered species. Nat Prod Res. 2020 Jan 13;:1-5 Authors: Michalska K, Marciniuk J, Stojakowska A Abstract The chemical studies of roots and aerial parts of Taraxacum portentosum Kirschner & Štěpánek, a member of the section Palustria (H. Lindb.) Dahlst. (Asteraceae), led to the isolation of one new eudesmanolide and 13 known compounds, including five sesquiterpenoids: taraxinic acid, 11β,13-dihydrotaraxinic acid, taraxinic acid β-glucopyranosyl ester...
Source: Natural Product Research - January 13, 2020 Category: Biochemistry Authors: Michalska K, Marciniuk J, Stojakowska A Tags: Nat Prod Res Source Type: research

Chemical composition of hydrosol volatiles of flowers from ten Paeonia  × suffruticosa Andr. cultivars from Luoyang, China.
Chemical composition of hydrosol volatiles of flowers from ten Paeonia × suffruticosa Andr. cultivars from Luoyang, China. Nat Prod Res. 2020 Jan 13;:1-5 Authors: Lei G, Song C, Luo Y Abstract Hydrosol volatiles from flowers of ten Paeonia × suffruticosa Andr. cultivars were analysed by gas chromatography-mass spectrometry (GC-MS) and GC-flame ionisation detector (GC-FID) for the first time. Fifty components were identified representing 97.6-99.8% of total composition, in which oxygenated compounds (87.4-99.8%) predominated. Hydrosol volatiles of five and two cu...
Source: Natural Product Research - January 13, 2020 Category: Biochemistry Authors: Lei G, Song C, Luo Y Tags: Nat Prod Res Source Type: research

New compounds from the aerial parts of Justicia gendarussa Burm.f. and their antioxidant and anti-inflammatory activities.
Abstract Three new compounds (1-3), together with six known compounds (4-9), were isolated from the ethyl acetate fraction of ethanol extract of the aerial parts of Justicia gendarussa Burm.f. All of these known compounds were isolated from the plant for the first time. Their structures including absolute configurations were elucidated on the basis of HR-ESI-MS, NMR spectroscopic analyses, single crystal X-ray diffraction and comparison with the literatures. Compounds 1-9 were tested for their antioxidant and anti-inflammatory activities. Compounds 5 and 8 showed the antioxidant activities with IC50 values of 28.6...
Source: Natural Product Research - January 13, 2020 Category: Biochemistry Authors: Zhang HX, Xia Z, Xu TQ, Chen YM, Zhou GX Tags: Nat Prod Res Source Type: research

Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells.
Abstract One new flavanonol 4 H-​1-​benzopyran-​4-​one,2-​(4-​hydroxyphenyl)​-​3,​7-​dihydroxy-​5-​methoxy-​8-​[5-​methyl-​2-​(1-​methylethenyl)​-​4-​hexenyl]​(21), and twenty-six known compounds 1-20, 22-27 were isolated from the dried root of Sophora flavescens (S. flavescens) in this chemical study. Their structures were elucidated according to the spectroscopic and spectrometric methods. All the isolated compounds were evaluated for their cytotoxicity against lung cancer A549 cells and colon cancer HCT116 cells. Among them, compound 21 showed relatively predom...
Source: Natural Product Research - January 13, 2020 Category: Biochemistry Authors: Huang XB, Yuan LW, Shao J, Yang Y, Liu Y, Lu JJ, Chen L Tags: Nat Prod Res Source Type: research

Hesperozygis ringens (Benth.) Epling: a study involving extraction, chemical profiling, antioxidant and biological activity.
This study aimed to determine the chemical markers of H. ringens extracts obtained via ultrasound-assisted (UAE-EtOH) and supercritical fluid (SFE-CO2) extractions. UAE-EtOH and SFE-CO2 extracts were characterised by UPLC-MS and GC-MS, respectively. Both products had their antioxidant activity, cytotoxicity and genotoxicity evaluated. Twelve compounds were found in the UAE-EtOH extract, including phenolic acids and flavonoids; the SFE-CO2 extract contained terpenes and phytosterols. The UAE-EtOH extract showed a greater antioxidant activity. Neither extract presented cytotoxicity or genotoxicity against human mononuclear b...
Source: Natural Product Research - January 10, 2020 Category: Biochemistry Authors: Dolwitsch CB, Pires FB, Frescura LM, Prá VD, Rieffel RC, Sagrillo MR, de Carvalho CA, Mazutti M, Pizzutti IR, da Rosa MB Tags: Nat Prod Res Source Type: research

Chemical composition, antioxidant and antimicrobial activities of Himalayan Fraxinus micrantha Lingelsh leaf extract.
Abstract The present investigation determines the phytochemical analysis, antioxidant and antibacterial potential of methanol extract of Himalayan Fraxinus micrantha (Lingelsh) leaves. Chemical analysis of extract revealed the presence of fifty five compounds. The extract was strongly characterised by tyrosol, esculetin, β-sitosterin, l-(+)-ascorbic acid 2,6-dihexadecanoate, (Z,Z)-6,9-cis-3,4-epoxy nonadecadiene as main components (62.6%). The F. micrantha extract presents IC50, 43.93 µg/ml and 68.90 µg/ml using DPPH and H2O2 scavenging assay, respectively. The antibacterial activity...
Source: Natural Product Research - January 10, 2020 Category: Biochemistry Authors: Kumar P, Sati SC Tags: Nat Prod Res Source Type: research

Verbascoside, synthetic derivatives and other glycosides from Argentinian native plant species as potential antitumoral agents.
ungitore CR Abstract A phytochemical study was performed on three native plant species from the central-western zone of Argentina: Buddleja cordobensis Grisebach, Baccharis salicina Torr. & A. Gray and Nepeta cataria L. We could obtain verbascoside (1) from B. cordobensis. From N. cataria, we could obtain 1, 5, 9-epi-deoxyloganic acid (2) L. Finally, we could isolate 2-β-(L-rhamnopyranosyl)-3-angeloyloxy-15-acetyloxy-7,13(14)-E-dien-ent-labdane (3) and 2-β-(L-rhamnopyranosyl)-3-α-angeloyloxy-15-hydroxy-7,13(14)-E-dien-ent-labdane (4) from B. salicina. Moreover, three derivatives from 1, and one...
Source: Natural Product Research - January 10, 2020 Category: Biochemistry Authors: Garro HA, Bruna-Haupt E, Cianchino V, Malizia F, Favier S, Menacho-Márquez M, Cifuente D, Fernández CO, Pungitore CR Tags: Nat Prod Res Source Type: research

Cytotoxicity and anti-inflammatory effects of the extract, fractions and alkaloids from Palicourea minutiflora (Rubiaceae).
SMO Abstract Palicourea species has been used in folk medicine in the treatment of some diseases including cancer and inflammatory disorders. This work aimed to evaluate the in vitro antiproliferative and in vivo topical anti-inflammatory activities of the methanolic extract, fractions and two major alkaloids isolated from Palicourea minutiflora. Methanolic extract, non-alkaloidal and alkaloidal fractions exhibited strong growth inhibition for ovarian cell lines (OVCAR-3, GI50 = 3.8 at 16.3 µg mL-1) and the vincosamide alkaloid revealed selective effect on the growth of glioma cell lines (U251, GI50 ...
Source: Natural Product Research - January 9, 2020 Category: Biochemistry Authors: de Moura VM, Ames FQ, Corrêa JGS, Peixoto MA, Amorim AMA, Pomini AM, de Carvalho JE, Ruiz ALTG, Bersani-Amado CA, Santin SMO Tags: Nat Prod Res Source Type: research

Antimicrobial compounds isolated from Tropaeolum tuberosum.
ÓO, Doménech MO Abstract Activity-guided fractionations of black tubers of Tropaeolum tuberosum led to the isolation of 3-[3-(3-pyridinyl)-1,2,4-oxadiazol-5-yl] benzonitrile (1) and [3,5-Bis (1,1-dimethylethyl)-4-hydroxyphenyl] ethenylidene] bis-phosphonic acid tetraethyl ester (2). Compounds 1 and 2 showed an antibacterial effect against almost all the strains assayed, especially compound 2, showing the same inhibition potential for Enterococcus faecalis and Salmonella enteritidis as the ampicillin (MIC = 1.5 μM) and a better potential than chloramphenicol which has a MIC of 3.5 &mu...
Source: Natural Product Research - January 8, 2020 Category: Biochemistry Authors: Ticona LA, Sánchez ÁR, Gonzáles ÓO, Doménech MO Tags: Nat Prod Res Source Type: research

Anti-inflammatory activity of the epicuticular wax and its isolated compounds catechin and gallocatechin from Eugenia brasiliensis Lam. (Myrtaceae) leaves.
This study describes anti-inflamatory activity of epicuticular wax (ECW) extracted from leaves of Eugenia brasiliensis Lam., and its isolated compounds, catechin and gallocatechin in a pleurisy model in mice. The results for exudation and cell migration showed that the extract and isolated compounds from the plant were effective in inhibiting these inflammatory parameters. The ECW demonstrated a dose-dependent effect on the inhibition of cell migration. The results for NOx levels reveals that the isolated compounds from Eugenia brasiliensis were effective in inhibiting the production of this inflammatory mediator, however,...
Source: Natural Product Research - January 8, 2020 Category: Biochemistry Authors: Siebert DA, Paganelli CJ, Queiroz GS, Alberton MD Tags: Nat Prod Res Source Type: research

A new abietane diterpene and anti-complementary constituents from Juniperus tibetica.
Abstract Anti-complementary activity-guided fractionation led to the isolation of a new abietane diterpene (1) and twenty-five known compounds (2-26) from the twigs and leaves of Juniperus tibetica. All the compounds were isolated from J. tibetica for the first time. The structure of 1 was assigned by spectroscopic data and X-ray crystallography analysis. Five lignans (2, 3, 7, 9 and 10), two flavones (19 and 22), and one coumarin (23) exhibited anti-complementary activity with CH50 values ranging from 0.3 to 3.69 mM. PMID: 31903783 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - January 5, 2020 Category: Biochemistry Authors: Zeng DL, Wang CY, Gao HQ, Chen DF, Lu Y Tags: Nat Prod Res Source Type: research

A new indole alkaloid and other constituents from Monodora minor and Uvaria tanzaniae: their antitrypanosomal and antiplasmodial evaluation.
Abstract Phytochemical investigation of the methanolic extract of Monodora minor Engl. & Diels (Annonaceae) stem bark yielded a new indole (E)-4-(1H-indol-5-yl)-but-3-en-2-one (1), a known indole 5-formyl-1H-indole (2) and an ubiquitous steroid sitosterol (3). The investigations of the methanolic extract of Uvaria tanzaniae Verdc. (Annonaceae) root bark yielded two previously reported C-benzylated dihydrochalcones namely uvaretin (4) and diuvaretin (5). Structures of the isolated compounds were elucidated based on NMR spectroscopy and high resolution electron ionization mass spectrometry (HR-EI-MS) data. All c...
Source: Natural Product Research - January 5, 2020 Category: Biochemistry Authors: Christopher R, Mgani QA, Nyandoro SS, Rousseau AL, Isaacs M, Hoppe HC Tags: Nat Prod Res Source Type: research

Cytotoxic and larvicidal activities of Stemona alkaloids from the aerial parts and roots of Stemona curtisii Hook.f.
Abstract A new Stemona alkaloid glycoside derivative, 6-hydroxy-5,6-seco-stemocurtisinoside (4), was isolated from the ethanolic extract of the aerial parts of Stemona curtisii Hook.f., together with stemocurtisine (1), (11Z)-1',2'-didehydrostemofoline (2) and 6-hydroxy-5,6-seco-stemocurtisine (3). Whereas, stemocurtisine (1), stemocurtisinol (5) and oxyprotostemonine (6) were isolated from the roots. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS experiments. The extract and the pure isolated compounds were evaluated for their cytotoxicities and their larvicidal activities against...
Source: Natural Product Research - January 3, 2020 Category: Biochemistry Authors: Chalom S, Panyakaew J, Phaya M, Pyne SG, Mungkornasawakul P Tags: Nat Prod Res Source Type: research

Induced production of a new polyketide in Penicillium sp. HS-11 by chemical epigenetic manipulation.
Abstract Chemical investigation into the culture broth of the plant endophyte Penicillium sp. HS-11 in the modified Martin's medium supplemented with subemylanilide hydroxamic acid (SAHA), a well-known histone deacetylase (HDACs) inhibitor, led to the isolation and identification of two induced products 4-epipenicillone B (1) and (R)-(+)-chrysogine (2). 4-epipenicillone B (1) was obtained as a new compound whose structure was elucidated by comprehensive spectroscopic methods including 1 D/2D NMR, HRESMS, and quantum chemistry calculations including DFT GIAO 13C NMR and ECD calculation. Acquisition of 4-epip...
Source: Natural Product Research - January 3, 2020 Category: Biochemistry Authors: Ying YM, Li L, Yu HF, Xu YL, Huang L, Mao W, Tong CP, Zhang ZD, Zhan ZJ, Zhang Y Tags: Nat Prod Res Source Type: research

Essential oils of Taxandria fragrans and Melaleuca alternifolia have effective antidermatophytic activities in vitro and in vivo that are antagonised by ketoconazole and potentiated in gold nanospheres.
, Santos DA Abstract The investigation of the effects of three essential oils (EOs) from Taxandria fragrans (FRA), Melaleuca alternifolia (TTO) and Boswellia serrata (IF), alone and combined with ketoconazole (KTZ), and their functionalised gold nanoparticles (AuNP) against Trichophyton interdigitale both in vitro and in vivo indicated that EOs presented activity against T. interdigitale. The combination of EOs and KTZ was antagonistic. FRA, TTO, gold nanoparticles capped with T. fragrans (AuNPFRA) and gold nanoparticles capped with M. alternifolia (AuNPTTO) presented antidermatophytic activity in vivo, with the c...
Source: Natural Product Research - January 2, 2020 Category: Biochemistry Authors: Carmo PHF, Costa MC, Franco PHC, Lage ACP, Rocha CEV, Chaves CR, Faraco AAG, Ladeira LO, Aguilar JLL, César IC, Paixão TA, Resende-Stoianoff MA, Santos DA Tags: Nat Prod Res Source Type: research

Inhibition of melanin production and tyrosinase activity by flavonoids isolated from Loranthus acutifolius.
ez Á Abstract Activity-guided fractionations of leaves and stems from Loranthus acutifolius led to the isolation of 2',4',6-trimethoxyflavone (1), 3',4',5-trihydroxy-6,7,8-trimethoxyflavone (2), 2'4'-dihydroxy-6'-methoxy-chalcone (3) and 4',5-dihydroxy-6,7,8-trimethoxyflavone (4). The potential for inhibition against melanin production and tyrosinase activity of these 4 compounds was tested in B16-F10 cells. 2',4',6-trimethoxyflavone, 3',4',5-trihydroxy-6,7,8-trimethoxyflavone, 2'4'-dihydroxy-6'-methoxy-chalcone and 4',5-dihydroxy-6,7,8-trimethoxyflavone showed an inhibitory activity of melanin production w...
Source: Natural Product Research - January 2, 2020 Category: Biochemistry Authors: Apaza Ticona L, Thiebaut Estrada C, Rumbero Sánchez Á Tags: Nat Prod Res Source Type: research

Phytochemical investigation of the flowers of Praxelis clematidea (Griseb.) R.M. King & H. Rob.
Phytochemical investigation of the flowers of Praxelis clematidea (Griseb.) R.M. King & H. Rob. Nat Prod Res. 2020 Jan 02;:1-5 Authors: Yang JN, Zhou XQ, Nong XH, Cao J, Hui Y, Wen M, Chen WH Abstract Chemical investigations of the flowers of Praxelis clematidea resulted in the isolation of 12 known compounds (1-12). Their structures were elucidated by extensive spectroscopic studies and chemical evidence. The structure and absolute configuration of 1 was precisely determined by a combination of 2 D NMR and quantum chemical calculations of ECD spectra analysis. Compounds 1, 4, 11 were isola...
Source: Natural Product Research - January 2, 2020 Category: Biochemistry Authors: Yang JN, Zhou XQ, Nong XH, Cao J, Hui Y, Wen M, Chen WH Tags: Nat Prod Res Source Type: research

Editorial.
PMID: 31893492 [PubMed - in process] (Source: Natural Product Research)
Source: Natural Product Research - January 1, 2020 Category: Biochemistry Authors: Cicero N Tags: Nat Prod Res Source Type: research

Bio-active sesquiterpenoids and norsesquiternoids from the Red Sea octocoral Rhytisma fulvum fulvum.
Abstract Three previously undescribed nardosinane-type sesquiterpenes (1-3), together with six known compounds (4-9) were isolated from the alcyonacean soft coral Rhytisma fulvum fulvum. 2 and 3 are 13-nornardosinane, and 6,7-seco-13-nornardosinane derivatives, respectively. 2 could be an artifact due to C-6 epimerization of the known one 4. Chemical structures were elucidated based on 1 D, 2 D NMR and MS spectral data. Compounds 1-8 showed cytotoxic activity against NCI-H1299, HepG2 and MCF-7 with IC50 values between 0.0352-0.0974, 0.0717-0.3745 and 0.0341-0.1325 mM, respectively. The antibac...
Source: Natural Product Research - December 30, 2019 Category: Biochemistry Authors: Ayyad SN, Deyab MA, Kosbar T, Alarif WM, Eissa AH Tags: Nat Prod Res Source Type: research

Morindaquinone, a new bianthraquinone from Morinda coreia roots.
Abstract Phytochemical investigation of the roots of Morinda coreia led to the isolation of one new bianthraquinone, morindaquinone (1), together with 12 known compounds, soranjidiol (2), rubiadin-1-methyl ether (3), 2-methoxy-1,3,6-trihydroxyanthraquinone (4), 1-hydroxy-2-methylanthraquinone (5), tectoquinone (6), nordamnacanthal (7), damnacanthal (8), 2-formylanthraquinone (9), 3-hydroxy-2-hydroxymethylanthraquinone (10), lucidin-ω-methyl ether (11), scopoletin (12) and (+)-mellein (13). The structures of these compounds were determined on the basis of extensive spectroscopic analyses, as well as by compar...
Source: Natural Product Research - December 26, 2019 Category: Biochemistry Authors: Chokchaisiri S, Siriwattanasathien Y, Thongbamrer C, Suksamrarn A, Rukachaisirikul T Tags: Nat Prod Res Source Type: research

In vitro antitubercular, anticancer activities and IL-10 expression in HCT-116 cells of Tinospora sinensis (Lour.) Merr. leaves extract.
Abstract Considering the importance of Tinospora sinensis in folklore as immunomodulant, the leaves subjected to cold maceration using ethanol, ethyl acetate and n-hexane and then screened for their antitubercular, anticancer and IL-10 expression (HCT-116) properties using luciferase reporter phage, MTT and flow cytometry assay methods, respectively. The results revealed that ethyl acetate and n-hexane extracts demonstrated the promising (p 
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: Badavenkatappa SG, Peraman R Tags: Nat Prod Res Source Type: research

Characterization of secondary metabolites from the berries of Ziziphus mucronata and their antioxidant properties.
Abstract Ziziphus mucronata is a medicinal plant used traditionally for treating various diseases. The antioxidant assay for the crude extracts obtained from the berries of Ziziphus mucronata was carried out using DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Purified antioxidant compounds were obtained by chromatographic methods and were subjected to structure elucidation using nuclear magnetic resonance (NMR). Berries of Ziziphus mucronata were found to have high antioxidant activity since their ethyl acetate extract had an IC50 value of 214.9 µg/mL and methanol extract had an IC50 value of 8.9&thins...
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: Parkar F, Njue AW, Langat MK, Omolo JO Tags: Nat Prod Res Source Type: research

Development and validation of a new HPTLC-HRMS method for the quantification of a potent pancreatic lipase inhibitory lead Echitamine from Alstonia scholaris.
Abstract Alstonia scholaris is an important indole alkaloid rich medicinal plant with diverse pharmacological activity. To understand the effect of extraction techniques, the stem bark sample of A. scholaris was subjected to continuous hot percolation, ultrasonic extraction, and cold maceration techniques. Continuous hot percolation technique extractive exhibited a potential pancreatic lipase (PL) inhibitory activity and further bio-assay guided fractionation resulted in the isolation of echitamine with a PL inhibitory activity (IC50 = 10.92 µM). A new validated HPTLC-HRMS method was developed for the...
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: George G, P S D, Paul AT Tags: Nat Prod Res Source Type: research

Antiinflammatory lanostane triterpenoids from Ganoderma lucidum.
Abstract Phytochemical and biological studies of the methanolic extracts from Ganoderma lucidum (Polyporaceae) have led to the identification and isolation of a new lanostane triterpenoid, ganosidone A (1), and its eight known derivatives (2‒9). The structure of new compound was determined by HREIMS, 1 D and 2 D NMR experiments and by comparing the acquired physicochemical data with the published values. All the compounds were evaluated for cancer chemopreventive potential based on their ability to inhibit nitric oxide (NO) production induced by lipopolysaccharides (LPS) in mouse macrophage RAW 264...
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: Koo MH, Chae HJ, Lee JH, Suh SS, Youn UJ Tags: Nat Prod Res Source Type: research

Pro-apoptoticeffect of diterpenoids from Fokienia hodginsii on acute myeloid leukemia cells.
Abstract Previously, we isolated four known diterpenoids, trans-communic acid (1), 13-oxo-15,16-dinor-labda-8(17), 11E-diene-19-oic acid (2), 3β-hydroxytotarol (3), and totarolone (4) from Fokienia hodginsii leaves. Further study demonstrated the antiproliferative activity of all four compounds in acute myeloid leukemia (OCI-AML) cells due to impaired cell cycle progression. Interestingly, 3β-hydroxytotarol (3) had very powerful bioactivity at low concentrations (5 µg/mL). PMID: 31872777 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: Hau DV, Sa NH, Tam NT, Diep NT, Hoang Anh NT, Thuy Linh NT, Ngoc Ni HT, Adorisio S, Delfino DV, Thuy TT Tags: Nat Prod Res Source Type: research

Isolation of tyrosine derived phenolics and their possible beneficial role in anti-inflammatory and antioxidant potential of Tithonia tubaeformis.
Abstract The methanolic extract of aerial parts of Tithonia tubaeformis showed significant antioxidant activity in DPPH assay. It was subjected to bioassay guided fractionation affording more active ethyl acetate fraction which on further purification led to the isolation and identification of a series of bioactive phenolic compounds having important biosynthetic relationship. Of these, 4-hydroxyphenethyl henicosanoate (tithonoid) is a new compound. Moreover, in the carrageenan induced paw edema test, significant attenuation of inflammation was also produced by the extract at 50-200 mg/kg. The structures of...
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: Nawaz NUA, Saeed M, Khan KM, Ali I, Bhatti HA, Shahid M, Faizi S Tags: Nat Prod Res Source Type: research

Physalis angulata concentrated ethanolic extract suppresses nociception and inflammation by modulating cytokines and prostanoids pathways.
In conclusion, CEEPA induces antinociceptive and anti-inflammatory effects, with improved pharmacological potency relative to pure physalins, associated to modulation of cytokine and cyclooxygenase pathways. PMID: 31872780 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: do Espírito Santo RF, Lima MDS, Juiz PJL, Opretzka LCF, Nogueira RC, Ribeiro IM, Tomassini TCB, Soares MBP, Villarreal CF Tags: Nat Prod Res Source Type: research

Two new isoquinoline alkaloids from the seeds of Nandina domestica.
Abstract Two new isoquinoline alkaloids, 6 R,6aS-N-nantenine Nβ-oxide (1), 6S,6aS-N-nantenine Nα-oxide (2), along with nine known alkaloids, nantenine (3), oxonantenine (4), protopine (5), nornantenine (6), N-methyl-laurotetanine (7), isocorydine (8), O-methyflavinantine (9), N-methyl-2,3,6-trimethoxymorphinan-dien-7-one Nβ-oxide (10) and (+)-10-O-methylhernovine Nβ-oxide (11) were isolated from the seeds of Nandina domestica. Their structures were elucidated by extensive analyses of spectroscopic data (IR, UV, HRESIMS, 1 D and 2 D NMR), ECD calculation and comparison with...
Source: Natural Product Research - December 24, 2019 Category: Biochemistry Authors: Qin J, Zhang SY, Zhang YB, Chen LF, Chen NH, Wu ZN, Luo D, Wang GC, Li YL Tags: Nat Prod Res Source Type: research

A new metabolite from Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel.
Abstract Cunninghamella blakesleeana-mediated biotransformation of an oral contraceptive drug, levonorgestrel (1), yielded a new metabolite, 13β-ethyl-17α-ethynyl-10,17β-dihydroxy-4,6-dien-3-one (2), and two known metabolites 3 (13β-ethyl-17α-ethynyl-10β,17β-dihydroxy-4-en-3-one), and 4 (13β-ethyl-17α-ethynyl-6β,17β-dihydroxy-4-en-3-one) at an ambient temperature using aqueous media. Hydroxylation and dehydrogenation of compound 1 was observed during the bio-catalytic transformation. The structure of a new metabolite 2 was determined by 1H, 13C, and 2DNMR a...
Source: Natural Product Research - December 17, 2019 Category: Biochemistry Authors: Kudaibergenova BM, Wahab AT, Siddiqui M, Abilov ZA, Choudhary MI Tags: Nat Prod Res Source Type: research

A new xanthone and a biphenyl from the flower and twig extracts of Garcinia mckeaniana.
Abstract The phytochemical investigation of the flower and twig extracts of Garcinia mckeaniana yielded a new xanthone, mckeanianone F (1) and a new biphenyl, mckeaniabiphenyl (2) together with 15 known compounds. The isolated compounds were characterized using spectroscopic techniques and mass spectrometry. Some of the isolated compounds from the twigs exhibited antimalarial and cytotoxic activities. PMID: 31842629 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 16, 2019 Category: Biochemistry Authors: Auranwiwat C, Limtharakul T, Pyne SG, Rattanajak R, Kamchonwongpaisan S Tags: Nat Prod Res Source Type: research

Phenolic profiling of different Jasminum species cultivated in Egypt and their antioxidant activity.
This study focused on the profiling of phenolic constituents in 80% methanolic extracts of the leaves of some Jasminum species cultivated in Egypt and their antioxidant activities. Phenolic profiling was performed by total phenolic contents, total flavonoid contents and HPLC-DAD for selected species in comparison to authentic standards. DPPH assay was used to estimate the antioxidant activities of Jasminum azoricum L., Jasminum humile L., Jasminum multiflorum (Burm.f.) Andrew, Jasminum officinale L., Jasminum sambac (Ait) L. "Arabian Nights cultivar" and Jasminum sambac (Ait) L. "Grand Duke of Tuscany cultiv...
Source: Natural Product Research - December 14, 2019 Category: Biochemistry Authors: El-Hawary SS, El-Hefnawy HM, Osman SM, El-Raey MA, Mokhtar Ali FA Tags: Nat Prod Res Source Type: research

Two new cephalochromin derivative from the Alternaria sp. ZG22.
Abstract Two new cephalochromin derivatives, prenylcephalochromin A (1), prenylcephalochromin B (2), along with cephalochromin (3) were isolated from the Alternaria sp. ZG22 obtained from a Dasymaschalon rostratum collected from the Hainan. The structures of two new compounds were elucidated by comprehensive spectroscopic methods. Compounds 1-3 showed α-glucosidase inhibitory activity. PMID: 31841031 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 14, 2019 Category: Biochemistry Authors: Song XM, Zhou XM, Li YL, Huang LB, Chen CC, Gao Y, He L, Mao XQ, Chen B, Liu JW, Liu HJ, Song XP, Han CR Tags: Nat Prod Res Source Type: research

Two new biflavanoids from Selaginella trichoclada Alsto.
Abstract Two new robustaflavones, (±)-trichocladabiflavone A (1) and uncinatabiflavone E (2), along with seven known biflavanoids (3-9) were isolated from the 70% EtOH extract of Selaginella trichoclada. Their structures and absolute configurations were established by extensive spectroscopic and circular dichroism (CD) analyses. Compound 1 was resoluted into optically pure enantiomers (+)-1 and (-)-1 by chiral-phase HPLC. Moreover, compounds 1 and 2 exhibited moderate cytotoxicity against A549 and HepG2 human cancer cell lines. PMID: 31841035 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 14, 2019 Category: Biochemistry Authors: Xie Y, Xu PS, Xu KP, Zou ZX, Zhou G, Li D, Li D, Li XM, Li J, Tan GS Tags: Nat Prod Res Source Type: research

Cytochalasins from endophytic Diaporthe sp. GDG-118.
Abstract The plant Sophora tonkinensis, possessed a range of active compounds, was traditionally used in the medicine of Chinese minorities. Endophytic fungi were isolated from this plant, of which the fungus Diaporthe sp. GDG-118 was fermented and extracted with methanol. The extract was screened by antifungal and antibacterial assays leading to the discovery of two new 21-acetoxycytochalasins (1-2) and five known cytochalasins (3-7). These two new compounds were elucidated by spectroscopic analyses, and further their absolute configurations were determined by the X-ray of compound 3 and comparing their experimen...
Source: Natural Product Research - December 13, 2019 Category: Biochemistry Authors: Huang X, Zhou D, Liang Y, Liu X, Cao F, Qin Y, Mo T, Xu Z, Li J, Yang R Tags: Nat Prod Res Source Type: research

Polysaccharide from Caulerpa lentillifera: extraction optimization with response surface methodology, structure and antioxidant activities.
Abstract Ultrasonic-assisted extraction based on Response Surface Methodology was applied to isolate a polysaccharide (CLP) from Caulerpa lentillifera obtained in the South China Sea and the highest yield of the crude polysaccharide was 11.8%. CLP consisted of xylose, galactose, glucose and glucuronic acid in a molar ratio of 2.00: 1.00: 0.26: 0.04, with a molecular weight of 115 kDa. The content of uronic acids and sulfate groups in CLP was 14.10% and 27.40%, respectively. CLP presented good radical scavenging activities against O2·-, DPPH radical, while the scavenging activities against OH· ...
Source: Natural Product Research - December 12, 2019 Category: Biochemistry Authors: Tian H, Liu H, Song W, Zhu L, Yin X Tags: Nat Prod Res Source Type: research

Chemical constituents from Schisandra sphenanthera and their cytotoxic activity.
Abstract Extensive phytochemical investigation of Schisandra sphenanthera leaves resulted in the isolation of six highly oxygenated nortriterpenoids (1-6) and five lignans (7-11) including a new pre-schisanartane-type, schisandrathera A (1), a new dibenzocyclooctadiene glycoside, schisandrathera B (7) and two new lignans, schisandrathera C (8) and schisandrathera D (9). Their chemical structures including absolute configurations were determined extensively by means of HR-ESI-MS, NMR, and ECD spectra. In addition, all isolated compounds were tested for cytotoxic activity against PC3 (prostate cancer) and MCF7 (brea...
Source: Natural Product Research - December 12, 2019 Category: Biochemistry Authors: Mai NT, Doan VV, Lan HTT, Anh BTM, Hoang NH, Tai BH, Nhiem NX, Yen PH, Park SJ, Seo Y, Namkung W, Kim SH, Kiem PV Tags: Nat Prod Res Source Type: research

Novel ferulic acid and benzophenone derivatives from the flower buds of Syzygium aromaticum.
Abstract Phytochemical investigation of clove resulted in the isolation of two new natural compounds, a ferulic acid derivative, sabrinic acid (1) and a benzophenone derivative (2) together with two known compounds kaempferol-3,5-dimethyl ether (3) and 4-methyl benzoic acid (4). Compounds 3 and 4 were isolated for the first time from the genus Syzygium. The structures of compounds were elucidated through modern spectroscopic techniques including 1D and 2D NMR spectroscopy. PMID: 31820659 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 10, 2019 Category: Biochemistry Authors: Kiran Z, Begum S, Sara S, Bano Z, Siddiqui BS Tags: Nat Prod Res Source Type: research

Bioassay-guided purification, GC-MS characterization and quantification of phyto-components in an antibacterial extract of Searsia lancea leaves.
Abstract Phytocompounds in an aqueous methanol (70% MeOH) leaf extract of Searsia lancea were separated using liquid-liquid partitioning techniques and gravity-assisted column chromatography. The resultant fractions were screened for antibacterial properties (minimum inhibitory concentration, MIC) against four bacterial strains (Enterococcus faecalis, Klebsiella pneumoniae, Neisseria gonorrhoeae and Staphylococcus aureus). Bioactive fractions were purified using preparative thin layer chromatography (TLC) and subjected to further antibacterial screening. Phytocompounds in antibacterial sub-fractions were character...
Source: Natural Product Research - December 10, 2019 Category: Biochemistry Authors: Vambe M, Naidoo D, Aremu AO, Finnie JF, Van Staden J Tags: Nat Prod Res Source Type: research

Sulphated flavones and pregnane-type steroids from Helicteres viscida.
Abstract In our search for anti-inflammatory constituents from Vietnamese plants, the methanolic extract of Helicteres viscida was found to exhibit inhibitory effect on LPS-induced NO production in RAW264.7 cells. Phytochemical investigation of this plant led to isolation of four sulphated flavones (1-4), including one new compound 5,3',4'-trihydroxy-7-methoxy-8-O-sulphate flavone (1), and two pregnane-type steroids (5 and 6), including one new compound 7-epi-heligenin B (5). Their structures were elucidated by 1D and 2D NMR as well as HR-QTOF-MS experiments. Among isolated compounds, heligenin B (6) exhibited pot...
Source: Natural Product Research - December 10, 2019 Category: Biochemistry Authors: Truong LH, Cuong NH, Dang TH, Dung TTM, Cham PT, Hanh TTH, Quang TH, Dang NH, Cuong NX, Nam NH, Minh CV Tags: Nat Prod Res Source Type: research

A new cycloartane triterpene bisdesmoside from the rhizomes of Actaea vaginata.
Abstract A new cycloartane triterpene bisdesmoside, soulieoside T (1), and one known compound, oleanolic acid (2), were isolated from the ethanolic extract of the rhizomes of Actaea vaginata. Their structures were elucidated by spectroscopic methods and by comparison with data reported in the literature. Compound 1 was evaluated for cytotoxic activities against three human cancer cell lines. PMID: 31821060 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 10, 2019 Category: Biochemistry Authors: Zhang M, Yang Q, Zhang X, Wu H Tags: Nat Prod Res Source Type: research

Dimeric glycosylated flavan-3-ol and antimicrobial in  vitro evaluation of Trichilia catigua extracts.
Dimeric glycosylated flavan-3-ol and antimicrobial in vitro evaluation of Trichilia catigua extracts. Nat Prod Res. 2019 Dec 09;:1-8 Authors: Ritter MR, Tempesta de OM, Makimori RY, Sereia AL, Simionato AS, Chierrito D, Galdino AF, Gonçalves de OA, Brentan da SD, Novello CR, Cristina de MD, Benedito Prado DF, João Carlos Palazzo de M Abstract Trichilia catigua is a tree known as "catuaba", widely distributed in Brazil. Studies carried out with T. catigua barks suggest that plant has antidepressant, antidiabetic, antimicrobial, antioxidant, antiviral, and preventive against...
Source: Natural Product Research - December 9, 2019 Category: Biochemistry Authors: Ritter MR, Tempesta de OM, Makimori RY, Sereia AL, Simionato AS, Chierrito D, Galdino AF, Gonçalves de OA, Brentan da SD, Novello CR, Cristina de MD, Benedito Prado DF, João Carlos Palazzo de M Tags: Nat Prod Res Source Type: research

29-Norlupane-1 β-hydroxy-3,20-dione, a new norlupane triterpenoid from the twigs and leaves of Phyllanthus acidus.
29-Norlupane-1β-hydroxy-3,20-dione, a new norlupane triterpenoid from the twigs and leaves of Phyllanthus acidus. Nat Prod Res. 2019 Dec 09;:1-6 Authors: Sichaem J, Vo HC, Nha-Tran T, Jarupinthusophon S, Niamnont N, Srikittiwanna K, Nguyen TK, Tran TN, Le TT, Duong TH Abstract A new norlupane triterpenoid, 29-norlupane-1β-hydroxy-3,20-dione (1), along with ten known compounds, 29-norlup-1-ene-3,20-dione (2), phyllanthol (3), phyllanthone (4), glochidone (5), lupeol (6), lupeone (7), 4-hydroxybenzoic acid (8), 4-hydroxybenzaldehyde (9), phyllane A (10) and methyl β-orsellinate (11) were ...
Source: Natural Product Research - December 9, 2019 Category: Biochemistry Authors: Sichaem J, Vo HC, Nha-Tran T, Jarupinthusophon S, Niamnont N, Srikittiwanna K, Nguyen TK, Tran TN, Le TT, Duong TH Tags: Nat Prod Res Source Type: research