Antifungal sesquiterpenes with post-harvest anthracnose control effect on bananas from the fungus Fusarium lateritium.
Abstract To search for antifungal leads, the metabolites of an insect-derived fungus Fusarium lateritium ZMT01 were investigated, providing five sesquiterpenes (1-5), including new molecules microsphaeropsisins D and E (1 and 2). The evaluated antifungal activities in vitro which are higher than the positive control triadimefon include: 1 and 2 towards Fusarium oxysporum (MICs 50, 25 mg L-1; triadimefon 100 mg L-1); 1, 2, 4 and 5 towards Penicillium italicum (MICs 25, 12.5, 25, 25; triadimefon 50 mg L-1), 1, 2 and 4 towards Colletotrichum musae (MICs 25, 12.5, 25; triadimefon 80 mg...
Source: Natural Product Research - January 15, 2021 Category: Biochemistry Authors: Zhu J, Xiong P, Li Z, Li J, Lin L, Fu X, Huang Y, Xiong Y, Li C Tags: Nat Prod Res Source Type: research

New secondary metabolites from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii.
Abstract One new 3,5-dimethylorsellinic acid (DMOA)-based meroterpenoid (1), one prenylated tryptophan derivative (2), together with ten known compounds (3-12) were isolated from the endophytic fungus Aspergillus sp. from Tripterygium wilfordii. Their structures and absolute configurations were determined by NMR spectroscopic data, HRESIMS data, UV and IR data as well as electronic circular dichroism (ECD) calculation. In structure, compound 1 was a rare example of DMOA-based meroterpenoid with a cis-fused C/D ring system, and compound 2 possessed an unusual (E)-oxime group. In bioactivity, the lovastatin analogue...
Source: Natural Product Research - January 15, 2021 Category: Biochemistry Authors: Deng M, Tan X, Qiao Y, Sun W, Xie S, Shi Z, Lu Y, Chen G, Qi C, Zhang Y Tags: Nat Prod Res Source Type: research

Terpestacin, a toxin produced by Phoma exigua var. heteromorpha, the causal agent of a severe foliar disease of oleander (Nerium oleander L.).
Abstract Since 1987, several cytochalasins were isolated from Phoma exigua var. heteromorpha, the causal agent of foliar blight disease of oleander (Nerium oleander L.), and chemically and biologically characterised. During the purification process of a large-scale production of cytochalasins A and B, necessary to continue the study on their anticancer activity, a metabolite having a different carbon skeleton compared to that of cytochalasans, was isolated. It was identified as terpestacin, a well-known toxic fungal stestertepenoid, isolated for the first time from P. exigua var. heteromorpha, by spectroscopic inv...
Source: Natural Product Research - January 15, 2021 Category: Biochemistry Authors: Masi M, Zonno MC, Boari A, Vurro M, Evidente A Tags: Nat Prod Res Source Type: research

Chemical compositions of the essential oils from Iranian populations of Rhabdosciadium aucheri Boiss. (Apiaceae).
Abstract Rhabdosciadium aucheri has a limited distribution in west, center, and south of Iran. The aim of the present study was to assess essential oil content and variability in seven natural populations employing GC-FID and GC-MS analyses. Aerial parts of the specimens were collected at the full flowering stage. Overall, 27 chemical components were determined in the populations. The essential oil yields varied from 0.05% to 0.12%. The most abundant compounds were germacrene D (10.7-51.7%), β-sesquiphellandrene (0.8-54.6%), β-elemene (0.3-39.5%), juniper camphor (3.5-20.8%), limonene (0.4-19.6%) and &al...
Source: Natural Product Research - January 13, 2021 Category: Biochemistry Authors: Kazemeini F, Asri Y, Mostafavi G, Kalvandi R, Mehregan I Tags: Nat Prod Res Source Type: research

Metabolite profiling of Cyanthillium cinereum (L.) H. Rob. and its herbal formulation by tandem mass spectroscopic analysis.
Abstract Cyanthillium cinereum is a medicinal plant commonly known as little ironweed is used in various traditional systems of medicines. In Ayurveda, it is known as Sahadevi and is used as remedy for many ailments. It has been reported to possess numerous biological properties including diaphoretic, anthelmintic, diuretic, lithontriptic, anti-inflammatory and anticancer activities. Metabolite profiling of aqueous extract of C. cinereum (CCE) and its herbal formulation KGS tablet has been carried out by liquid chromatography tandem mass spectroscopic analysis. ESI-MS/MS based characterisation led to the identific...
Source: Natural Product Research - January 12, 2021 Category: Biochemistry Authors: Sulaiman CT, Ramesh PR, Mahesh K, Anandan EM, Praveen M, Balachandran I Tags: Nat Prod Res Source Type: research

Fissistiganoids A and B: two new flavonoids from the Fissistigma tungfangense.
Abstract Two new flavanoids fissistiganoids A and B (1 and 2), together with two known pterocarpans derivatives (3 and 4), were isolated from the stems of Fissistigma tungfangense. The structures of these compounds were elucidated using comprehensive spectroscopic methods. The absolute configurations of fissistiganoids A and B (1 and 2) were determined by comparing their ECD spectra with quantum-mechanics ECD calculations. The inhibitory activities of all compounds against three cancer cell lines HeLa, MCF-7 and A549 were evaluated. Compounds 1-4 showed moderate inhibitory effects on HeLa, MCF-7 and A549 cells wit...
Source: Natural Product Research - January 12, 2021 Category: Biochemistry Authors: Zhong WL, Zhou XM, Yi JL, Song XM, Zhang B, Yang JY, Chen GY Tags: Nat Prod Res Source Type: research

Saffloflavone, a new flavonoid from the flowers of Carthamus tinctorius L. and its cardioprotective activity.
Abstract A new flavonoid, saffloflavone , along with six known compounds, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, quercetin-3-O-β-d-glucoside, quercetin-7-O-β-d-glucoside, luteolin-7-O-β-d-glucoside and kaempferol 3-O-β-d-glucoside were isolated from the flowers of Carthamus tinctorius L. All the structures were determined by interpretation of their spectroscopic data. The cardioprotective effects of all the isolates against oxidative stress of H9c2 cells induced by H2O2 were investigated. The results showed that compounds 4-6 exhibited protective effects against of H9c2 cells in...
Source: Natural Product Research - January 12, 2021 Category: Biochemistry Authors: Wang MN, Cao YG, Wei YX, Ren YJ, Liu YL, Chen X, He C, Zheng XK, Feng WS Tags: Nat Prod Res Source Type: research

A new homoisoflavan from Dracaena cinnabari Balf. f. resin: α-glucosidase and COX-II inhibitory activity.
A new homoisoflavan from Dracaena cinnabari Balf. f. resin: α-glucosidase and COX-II inhibitory activity. Nat Prod Res. 2021 Jan 11;:1-6 Authors: Helal IE, Elsbaey M, Zaghloul AM, Mansour ES Abstract A new homoisoflavan, identified as (3 R)-7-hydroxy-3',4'-methylenedioxyhomoisoflavan, was isolated from Dracaena cinnabari Balf. f. resin. The structure was elucidated by one- and two-dimensional NMR spectroscopy as well as high resolution mass spectrometry. In addition, a diverse group of flavonoids were isolated, representing homoisoflavans, flavans, flavanones, chalcones and dihydrochalcon...
Source: Natural Product Research - January 11, 2021 Category: Biochemistry Authors: Helal IE, Elsbaey M, Zaghloul AM, Mansour ES Tags: Nat Prod Res Source Type: research

Aphrodisiac and spermatogenic potential of alkaloidal fraction of Argyreia nervosa (Burm. f.) Bojer roots in male rats.
Abstract Roots of Argyreia nervosa (Burm. f.) Bojer are used as aphrodisiac and spermatogenic in the treatment of male infertility. The present studies included in vivo assessment of alkaloidal fraction in male rats on testosterone synthesis in leydig cells. Studies included oral administration of doses of alkaloidal fraction (10, 25 and 50 mg/kg) to rats. Results showed 100% and 146.7% increment in serum testosterone and serum cholesterol at 50 mg/kg dose level, respectively. At the same dose, 135.29% increase in mounting frequency and 357.14% increase in intromission frequency were also observ...
Source: Natural Product Research - January 10, 2021 Category: Biochemistry Authors: Vyas N, Raval M Tags: Nat Prod Res Source Type: research

Is ricicomin a an alkaloid?
PMID: 33426937 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - January 10, 2021 Category: Biochemistry Authors: Ribeiro PR Tags: Nat Prod Res Source Type: research

Isolation and neuroprotective prospective of novel bioactive compound "3-(3,4-dimethoxyphenyl)-1-(4-methoxyphenyl) prop-2-en-1-one" against ketamine-induced cognitive deficits in schizophrenia: an experimental study.
In conclusion, this is the first study of new flavonoid compound of CP and its protective efficacy against schizophrenia. PMID: 33415998 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - January 8, 2021 Category: Biochemistry Authors: Chintha V, Wudayagiri R Tags: Nat Prod Res Source Type: research

Design, synthesis and pharmacological evaluation of novel Artemisinin-Thymol.
Abstract A molecular hybridization of natural products is a new concept in drug discovery and having critical roles to design new molecules with improved biological properties. Hybrid molecules display higher biological activities when compared to the parent drugs. In the present study, two natural products (thymol and artemisinin (ART)) are used for the synthesis of new hybrid thymol-artemisinin. After characterization, the cytotoxic activity of ART-thymol was tested against different cancer cell lines and non-cancerous human cell line. ART-Thymol show the cytotoxic effect with EC50 values 70,96μM for HepG2, 9...
Source: Natural Product Research - January 8, 2021 Category: Biochemistry Authors: Kavak E, Mutlu D, Ozok O, Arslan S, Kivrak A Tags: Nat Prod Res Source Type: research

Chemical composition of the essential oil from different vegetative parts of Foeniculum vulgare subsp. piperitum (Ucria) Coutinho (Umbelliferae) growing wild in Sicily.
Abstract In the present study, the chemical compositions of the essential oils from roots, stems, leaves and fruits of Foeniculum vulgare subsp. piperitum collected in Sicily were evaluated by GC and GC-MS. The main components of the roots were terpinolene (33.15%), γ-terpinene (12.18%) and fenchyl acetate (11.23%). Stems and leaves were very rich in α-phellandrene (36.85% and 41.59%, respectively) and β-phellandrene (19.68% and 25.79%, respectively), whereas the main components of fruits were terpinolene (20.10%) and limonene (17.84%) These results were compared with those of the EOs of the same ...
Source: Natural Product Research - January 7, 2021 Category: Biochemistry Authors: Ilardi V, Badalamenti N, Bruno M Tags: Nat Prod Res Source Type: research

Insecticidal activity of copper (II) complexes with flavanone derivatives.
Abstract In this work, we describe the insecticidal activity against Spodoptera frugiperda of flavanone derivatives (naringin, naringenin and hesperidin) complexed to copper (II). For the assays, the compounds were incorporated into an artificial diet and offered to S. frugiperda during its larval period. The duration of larval and pupal phases, the weight of pupae and the percentage of dead insects at the end of the larval phase were evaluated. Among the tested compounds, the free flavanones 1 and 3 and the complexes 4 and 6 showed a shortening of the larval phase when compared to the control. Complex 9 showed th...
Source: Natural Product Research - January 6, 2021 Category: Biochemistry Authors: Franceschini Sarria AL, Matos AP, Volante AC, Bernardo AR, Sabbag Cunha GO, Fernandes JB, Rossi Forim M, Vieira PC, da Silva MFDGF Tags: Nat Prod Res Source Type: research

Two new sesquiterpenes from the rhizomes of Atractylodes macrocephala and their biological activities.
Abstract Two new sesquiterpenes, named selina-4(14),7,11-trien-9-ol (1) and selina-4(14),11-dien-7-ol (2), along with two known compounds were isolated from rhizomes of Atractylodes macrocephala Koidz. All structures were assigned on the basis of detailed spectroscopic analyses. The absolute configuration of 1 was established by TDDFT-ECD calculations. Compound 1 was found to moderately inhibit LSD1 activity with IC50 value of 34.0 μM. Compounds 1 and 4 exhibited a regulate effect on Keap1-Nrf2-ARE pathway. PMID: 33401972 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - January 6, 2021 Category: Biochemistry Authors: Zhao YN, Gao G, Ma JL, Xu RZ, Guo T, Wu LM, Liu XG, Xie ZS, Xu JY, Zhang ZQ, Wang P Tags: Nat Prod Res Source Type: research

Profile of phenolic compounds in jabuticaba (Myrciaria sp.) a potential functional ingredient.
ÉCBA Abstract Phenolic compounds have attracted a lot of attention due to their benefits to human health. Jabuticaba (Myrciaria sp.) fruit has been described as an excellent source of these compounds, while Jabuticaba leaf, considered as plant residue, has shown functional effects. The present study aimed to characterize the phenolic profile in two different leaves extracts (hydroalcoholic ethanol and butanol) of Myrciaria sp. by UPLC-ESI-QTOF-MSE. A total of 40 phenolic compounds were tentatively identified. Jabuticaba leaf extracts presented a rich and diversified composition of phenolic compounds, especi...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Dos Santos MCP, Cavalcanti EDC, Santos MCB, Seljan MP, Cameron LC, Ferreira MSL, Gonçalves ÉCBA Tags: Nat Prod Res Source Type: research

Structure elucidation of a novel cyclic tripeptide from the marine-derived fungus Aspergillus ochraceopetaliformis DSW-2.
Abstract A novel cyclic tripeptide, sclerotiotide M (1), was isolated from the culture of a marine derived fungus Aspergillus ochraceopetaliformis DSW-2, together with four known compounds (2-5). The planar structure of 1 was established by 1 D and 2 D NMR data, supported by mass spectrometry, and the relative configuration was established by calculated NMR chemical shifts coupled with a statistical method (DP4+). All the compounds (1-5) displayed weak cytotoxic activities against cancer cell lines HPAC and BXPC3, with IC50 values over 20 μM. PMID: 33397147 [PubMed - as supplied by pub...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Liao Y, Hong X, Yang J, Qin JJ, Zhang B, Lin J, Shao Z, Wang W Tags: Nat Prod Res Source Type: research

Thionation of quinolizidine alkaloids and their derivatives via Lawesson's reagent.
Abstract Direct thionation of quinolizidine alkaloids (-)-cytisine, methylcytisine, thermopsine and some of their carbonyl derivatives was realized. It was established that carrying out of the reaction in the boiling toluene with 0.5 eq. of Lawesson's reagent (LR) is most effective for synthesis of thio analogues of methyl-, allyl-, benzylcytisine and thermopsine. It was found, that formation of thioamides is preferable in the case with starting 3-carboxamides of (-)-cytisine or 2-oxo and 4-oxo derivatives of methylcytisine; and an excess of LR is needed for their exhaustive thionation. It was shown, that thionati...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Koval'skaya AV, Petrova PR, Tsypyshev DO, Lobov AN, Tsypysheva IP Tags: Nat Prod Res Source Type: research

Two new quinones and six additional metabolites with potential anti-inflammatory activities from the roots of Juglans mandshurica.
Abstract Two new quinones, 4-(5-hydroxy-1,4-dioxo-1,4-dihydronaphtha-len-3-ylamino)-butyric acid methyl ester (compound 1) and 1,3-dimethoxycarbonyl-8-hydroxy-9,10-anthraquinone (2), and six known compounds (3-8) were isolated from the roots of Juglans mandshurica Maxim., a member of the Juglandaceae family. The chemical structures of the compounds were elucidated by nuclear magnetic resonance spectroscopy and compared with data from the literature. The isolated compounds were evaluated for their ability to inhibit the production of nitric oxide, tumour necrosis factor-α, and interleukin-6 by the mouse macro...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Piao S, Qi Y, Jin M, Diao S, Zhou W, Sun J, Jin X, Li G Tags: Nat Prod Res Source Type: research

Brandisianones F and G from Millettia brandisiana Kurz and their cytotoxicity.
Abstract A new flavanone and a new chalcone, brandisianones F and G, were purified from the roots of Millettia brandisiana Kurz, moreover, sixteen known compounds were found. The chemical structures of all isolated compounds were identified using spectroscopic methods including 1D-NMR, 2D-NMR, MS, IR and CD data. Chalcone 15 exhibited the most cytotoxic activity against liver cancer, HepG2, and cholangiocarcinoma, KKU-M156, cell lines with IC50 values of 1.74 ± 0.91 and 1.95 ± 0.95 µg/mL, respectively. Chalcones 2, 14, 16 and 18 as well as flavones 5, 6 and 12...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Arthan S, Pornchoo C, Prawan A, Tontapha S, Amornkitbamrung V, Yenjai C Tags: Nat Prod Res Source Type: research

Improvement in phloroglucinol compound extracted from different parts of Eugenia umbelliflora monitored by LC-UV and antimicrobial activity.
This study aims to evaluate the extraction conditions of E. umbelliflora, using ethanol as solvent, focusing on the phloroglucinol and antimicrobial activity. In order to optimize the extraction conditions, ethanol 50, 70 and 90 oGL was used as a solvent in the proportions of 1:20 (w/v) of drug:solvent ratio (D:S), stirring (330 rpm) at room temperature during 4 h, monitored by LC-UV and antimicrobial assay. The LC-UV method developed was linear over a concentration range of 3.4-68.0, 5.3-106.0 and 5.0-100.8 μg.mL-1 of eugenial C, eugenial D and eugenial E, having LOQ of 1.68, 1.33 and 0.8 &m...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Farias IV, Amorim CM, Graff E, Breia I, Dos Santos MC, Norberto S, Faqueti LG, Bresolin TMB, Bella Cruz A, Meyre-Silva C Tags: Nat Prod Res Source Type: research

UHPLC-PDA-ESI-MS profile of phenolic compounds in the aerial parts of Cuphea ingrata Cham. & Schltdl.
UHPLC-PDA-ESI-MS profile of phenolic compounds in the aerial parts of Cuphea ingrata Cham. & Schltdl. Nat Prod Res. 2021 Jan 04;:1-5 Authors: Sobolewska D, Owczarek A, Olszewska M, Paulino N, Podolak I, Paśko P, Wróbel-Biedrawa D, Michalska K Abstract The purpose of the current study was a qualitative UHPLC-PDA-ESI-MS analysis of phenolic compounds in the aerial parts of Cuphea ingrata, which led to detection of over sixty constituents: tannins, flavonoids, phenolic acids and their derivatives. The presence of oenothein B-type macrocyclic dimeric ellagitannins seems to be of particular imp...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Sobolewska D, Owczarek A, Olszewska M, Paulino N, Podolak I, Paśko P, Wróbel-Biedrawa D, Michalska K Tags: Nat Prod Res Source Type: research

Two new glycosides from Panzerina lanata (L.) Soj ák.
Two new glycosides from Panzerina lanata (L.) Soják. Nat Prod Res. 2021 Jan 04;:1-5 Authors: Wang Q, Bao Y, Wang M, Wang Q Abstract Two new glycosides, namely panalaside A (1) and panalaside B (2) were isolated from from Panzerina lanata (L.) Soják. The structures of 1 and 2 were elucidated by spectroscopic methods, including UV, IR, HR-ESI-MS and extensive 1 D and 2 D NMR techniques. PMID: 33390026 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Wang Q, Bao Y, Wang M, Wang Q Tags: Nat Prod Res Source Type: research

Cannadicas A and B: two new oligosaccharide esters from the roots of Canna indica L.
Abstract Two new sucrose derivatives, named as cannadica A (1) and cannadica B (2), and eight known compounds, 6'-O-acetyl-3-O-(E)-p-coumaroylsucrose (3), heterophylloside C (4), 6'-O-vanilloylarbutin (5), isotachioside (6), 2,6-dimethoxy-p-hydroquinone 1-O-β-D-glucopyranoside (7), 3,5-dimethoxy-p-hydroquinone 1-O-β-D-glucopyranoside (8), benzyl glucoside (9), and 3,4-dihydroxybenzaldehyde (10) were isolated from the roots of Canna indica L. by various chromatographic methods. Their structures were established by extensive spectroscopic analysis (UV, IR, HR-ESI-MS and NMR) and by comparison of the spectr...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Anh LT, Hieu N, Trang DT, Tai BH, Nhiem NX, Kiem PV Tags: Nat Prod Res Source Type: research

9,10-Dihydro-5-hydroxy-2,3,6-trimethoxyphenanthrene-1,4-dione: a new dihydrophenanthrene from commercial cannabis and its effect on zebrafish larval behaviour.
lis L Abstract A new dihydrophenanthrene derivative namely 9,10-dihydro-5-hydroxy-2, 3,6-trimethoxyphenanthrene-1,4-dione (1) was isolated from commercial cannabis product together with 4,5-dihydroxy-2,3,6-trimethoxy-9,10-dihydrophenanthrene (2), 4-hydroxy-2,3,6,7-tetramethoxy-9,10-dihydrophenanthrene (3), combretastatin B-2 (4) and isocannbispiradienone (5). Structure elucidation of the isolated compounds were done based on the interpretation of the mass spectrometry (MS) and nuclear magnetic resonance (NMR) data. New dihydrophenanthrene derivative (1) was tested for its effect on zebrafish larval behaviour. Prel...
Source: Natural Product Research - January 4, 2021 Category: Biochemistry Authors: Banskota AH, Stefanova R, Hui JPM, Berrué F, Achenbach JC, Ellis L Tags: Nat Prod Res Source Type: research

A new antidiabetic and anti-inflammatory biflavonoid from Schinus polygama (Cav.) Cabrera leaves.
Abstract A new biflavonoid, luteolin-(6→8'')-apigenin was isolated from 80% methanol extract of Schinus polygama (Cav.) Cabrera leaves (Anacardiaceae). The structure was elucidated by 1D and 2D-NMR spectroscopic data. This compound exhibited in vitro antidiabetic effect via α-amylase assay. Furthermore, it possesses anti-inflammatory activity through membrane stabilization effect on erythrocytes. PMID: 33356557 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 28, 2020 Category: Biochemistry Authors: El-Nashar HAS, Mostafa NM, Eldahshan OA, Singab ANB Tags: Nat Prod Res Source Type: research

Phytochemical characterization, genotoxicity, cytotoxicity, and antimicrobial activity of Gautheria procumbens essential oil.
This study investigated the chemical constituents of Gaultheria procumbens essential oil and is the first to relate cytogenotoxicity with oxidative metabolism and antimicrobial activity. Chromatographic analysis of the essential oil showed methyl salicylate (99.96%) and linalool (0.04%) as the major compounds. The essential oil showed no signs of cytogenotoxicity at different concentrations (1.82 to 58.34 mg mL-1). Furthermore, G. procumbens essential oil and methyl salicylate were used to evaluate the minimal inhibitory concentrations (MIC) and minimal microbicidal concentrations (MMC). The results showed efficacy ...
Source: Natural Product Research - December 28, 2020 Category: Biochemistry Authors: Verdi CM, Machado VS, Machado AK, Klein B, Bonez PC, de Andrade ENC, Rossi G, Campos MM, Wagner R, Sagrillo MR, Santos RCV Tags: Nat Prod Res Source Type: research

Phenolics diversity among wild populations of Salvia multicaulis: as a precious source for antimicrobial and antioxidant applications.
Abstract The genus Salvia L. belongs to the Lamiaceae family including several known species rich in natural compounds that are extensively used in pharmaceutical, food, and cosmetic industries. Salvia multicaulis populations contain a broad diversity of flavonoids and phenolic acids. The present study aimed to explore biological and pharmacological effects including antimicrobial and antioxidant activities of nineteen S. multicaulis populations (SMPs) grown in Iran for the first time. High content of rosmarinic acid (RA) in SMP12 (Gazan) (5.65 ± 0.33 mg/g DW) caused high antimicrobial ...
Source: Natural Product Research - December 28, 2020 Category: Biochemistry Authors: Tavan M, Azizi A, Sarikhani H, Mirjalili MH, Rigano MM Tags: Nat Prod Res Source Type: research

Two new benzophenone glycosides from the aerial parts of Hypericum przewalskii.
Abstract Plants of the genus Hypericum contain various types of secondary metabolites that exhibited extensive biological activities. In the ongoing efforts to discover natural neuroinflammatory inhibitors with the potential to develop into therapeutic agents for neurodegenerative diseases, two new benzophenone glycosides, hyperewalones A and B (1 and 2), along with eight known compounds (3-10), were isolated from the aerial parts of Hypericum przewalskii. Their structures were elucidated by comprehensive analysis of IR, HRESIMS, 1D and 2D NMR spectra, and chemical derivatization. The anti-neuroinflammatory activi...
Source: Natural Product Research - December 28, 2020 Category: Biochemistry Authors: Xie JY, Jin Q, Gao JM, Zong SC, Yan XT Tags: Nat Prod Res Source Type: research

Novel bioactive peptides sequences released by in vitro digestion of proteins isolated from Amaranthus hypochondriacus.
, González-Olivares LG Abstract Amaranth is a protein-rich seed, highly consumed in Mexico and reported as a potential source of bio-peptides with physiological function. Therefore, the objective of this study was to evaluate and identify bioactive peptide sequences from amaranth protein fractions released by pepsin and pancreatin in vitro digestion. Multifunctional bioactivities of peptides were measured through antihypertensive, antithrombotic and antioxidant assays. Peptide sequences were identified by analysis with a Nano-LC-ESI-MS/MS. With these results, it was demonstrated that the in vitro enzymatic ...
Source: Natural Product Research - December 28, 2020 Category: Biochemistry Authors: Ayala-Niño A, Castañeda-Ovando A, Jaimez-Ordaz J, Rodríguez-Serrano GM, Sánchez-Franco JA, González-Olivares LG Tags: Nat Prod Res Source Type: research

Two new phenolic compounds from the Vietnamese lichen Parmotrema tinctorum.
Abstract Chemical investigation of the lichen Parmotrema tinctorum (Nyl.) Hale led to the isolation of two new phenolic compounds, 2-ethylhexyl orsellinate (1) and tinctorinone (2). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature data. The 2-ethylhexyl ester group of 2-ethylhexyl orsellinate is uncommon among lichen metabolites. Tinctorinone revealed strong inhibition towards α-glucosidase. PMID: 33356561 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Bui VM, Duong TH, Nguyen TA, Nguyen TN, Nguyen NH, Nguyen HH, Chavasiri W, Nguyen KP, Huynh BL Tags: Nat Prod Res Source Type: research

Bio- and chemo- transformations of glabranin and 7-O-methylglabranin and cytotoxic evaluations of the transformed products.
Abstract The biotransformation of glabranin (1) with Aspergillus niger and Cunninghamella blakesleeana favoured the formation of benzofuran derivatives (3 and 4), while in contrast, its acid-catalysed chemical transformation favoured the formation of benzopyran derivatives (6 and 7). Compound 6 was further biooxidised at C-4'. Biotransformation of 7-O-methylglabranin (2) proceeded via oxidation of the prenyl group and C-4' by the same fungi, and the obtention of 11 mimics the biosynthesis of this last compound. Some compounds displayed moderate antiproliferative activity against selected human cancer cell lines, w...
Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Cano-Flores A, Espinoza M, Delgado G Tags: Nat Prod Res Source Type: research

New triazole-bearing gramine derivatives - synthesis, structural analysis and protective effect against oxidative haemolysis.
icz B Abstract The new series of triazole-bearing gramine derivatives were synthesized through a CuAAC procedure. The structures of all newly obtained compounds were confirmed by spectroscopic analysis and DFT methods. The obtained derivatives were screened for their protective potency against oxidative haemolysis induced by free radicals generated from 2,2'-azobis(2-methylpropionamidine) dihydrochloride (AAPH). Our work demonstrates that derivatives with propyl or octyl linker and phthalimide group associated with indole-triazole moiety, which have a folded structure, effectively protect human erythrocytes agains...
Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Kozanecka-Okupnik W, Sierakowska A, Berdzik N, Kowalczyk I, Mrówczyńska L, Jasiewicz B Tags: Nat Prod Res Source Type: research

Development, characterisation, stability study and antileukemic evaluation of nanoemulsions containing Astrocaryum aculeatum extract.
The objective of this work was to produce and characterise nanoemulsions containing tucumã extract and to evaluate the performance of the nanostructure and the free compound regarding antitumor activity, cytotoxicity, and oxidative metabolism in NB4/APL cells. The nanoemulsions showed adequate physicochemical characteristics (average size approx. 200 nm, polydispersity index less than 0.3, negative zeta potential and acid pH) maintained stable up to 90 days of storage in refrigeration condition. The nanoformulations did not present protein corona formation. Blank nanoemulsion treatments showed moderate...
Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Copetti PM, Gündel SDS, de Oliveira PSB, Favarin FR, Ramos AP, Pintos FG, Pappis L, Gündel A, Machado AK, Ourique AF, Sagrillo MR Tags: Nat Prod Res Source Type: research

Chemical constituents from the South China sea soft coral Sinularia humilis.
Abstract A new diterpenoid with an unusual capnosane skeleton, sinuhumilol A (1), alone with twelve known diverse compounds (2-13), were isolated from the South China Sea soft coral Sinularia humilis. Their structures and stereochemistry were elucidated by extensive spectroscopic analysis, quantum chemical calculations, and/or by the comparison of the spectroscopic data with those reported in the literature. In bioassay, compound 11 exhibited interesting specific cytotoxicity against the human colon adenocarcinoma cell line HT-29 with IC50 value of 12.5 µM. PMID: 33356576 [PubMed - as supplied by...
Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Li J, Huan XJ, Wu MJ, Chen ZH, Chen B, Miao ZH, Guo YW, Li XW Tags: Nat Prod Res Source Type: research

Diketopiperazine and enterotoxin analogues from the mangrove derived-soil Streptomyces sp. SCSIO 41400 and their biological evaluation.
Abstract A new diketopiperazine, cyclo-( d -8-acetoxyl-Pro- l -Leu) (1), together with eight known compounds (2-9) including three enterotoxins (2-4), four diketopiperazines (5-8) and maltol (9), were isolated from the mangrove derived-soil Streptomyces sp. SCSIO 41400. The planar structures of all compounds were determined from analysis of NMR spectra, MS, optical rotation and comparing with literature data. The absolute configuration of compound 1 was assigned by electronic circular dichroism (ECD). The isolated compounds (1-9) were tested for their acetyl cholinesterase (AChE) and pancreatic lipase (PL) enzyme ...
Source: Natural Product Research - December 24, 2020 Category: Biochemistry Authors: Song MM, Xie YH, Chen WH, Hu YW, Zhao K, Liu YH, Huang XL, Liu QC, Wang JF Tags: Nat Prod Res Source Type: research

New phenolics from Uraria crinita (L.) DC.
Abstract Reinvestigation of a methanol extract of Uraria crinita afforded a new 3- hydroxyisoflavanone, 3,5,7,2',4'-pentahydroxyisoflavanone (1), two new monoaryl glucosides, 3,4-dimethoxyphenyl 1-O-(6'-O-acetyl)-β-D-glucopyranoside (2) and 3,4,5-trimethoxyphenyl 1-O-(6'-O-acetyl)-β-D-glucopyranoside (3), in addition to three known compounds, 3'-O-methylorobol (4), robusflavone B (5), and apigenin (6). The structural elucidation of these compounds was achieved by analyses of their spectroscopic data (HR-ESI-MS, 1 D- and 2 D-NMR) and acidic hydrolysis. The U. crinita extracts and compounds 1...
Source: Natural Product Research - December 22, 2020 Category: Biochemistry Authors: Thien DD, Tai BH, Dai TD, Sa NH, Thuy TT, Hoang Anh NT, Tam NT Tags: Nat Prod Res Source Type: research

A new diterpernoid glycoside from the fruit of Forsythia suspensa.
Abstract One new diterpernoid glycoside, lanceolatinoside A (1), together with one known iridoid glycoside, luzonoside C (2) were isolated from the fruit of Forsythia suspensa. The structure of the new compound (1) was elucidated through 1 D and 2 D NMR spectroscopic data, and HR-ESIMS. Compound 2 was identified as luzonoside C (2) on the basis of NMR spectroscopic data analyses and comparison with those reported in the literature. PMID: 33342282 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Ma N, Sun C, Wei Q, Wang Y, Yan X, Li C, Pei Y Tags: Nat Prod Res Source Type: research

Phytochemical constituents and biological activities of Dianthus helenae Vved., growing in Uzbekistan.
Abstract In the present study, six known compounds were investigated that were isolated from the aerial parts of plant Dianthus helenae Vved. The structures of these compounds were identified as polypodine B (1), 2,3,20,22-diacetonide-20-hydroxyecdysone (2), 20-hydroxyecdysone (3), cyasterone (4), α-ecdysone (5) and 2-deoxy-α-ecdysone (6). Their structures were confirmed by NMR-, ESI-MS, and IR-spectroscopy. The compounds (5) and (6) are reported for the first time from this species. Furthermore, compounds (2) and (4) were isolated for the first time from the Caryophyllaceae family. In addition, all th...
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Yusupova U, Usmanov D, Azamatov A, Ramazonov N, Rejepov J Tags: Nat Prod Res Source Type: research

Two undescribed diarylheptanoids from green husk of Carya illinoinensis as acetylcholinesterase inhibitors.
Abstract Two undescribed diarylheptanoids, 3-(R)-acetyl-1-(3',4'-dihydroxyphenyl)-7-(4''-hydroxy-3'' -methoxyphenyl)-heptane (1) and 11-Hydroxy-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane (2) together with known compounds, namely, 11-Oxo-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane (3) 3,4,5-Trihydroxytetralone (4) 4,8- Dihydroxytetralone (5), 4,5-Dihydroxytetralone (6), 5,8-Dihydroxy-3-methoxytetralone (7) were isolated from ethyl acetate extract of the green husk of Carya illinoinensis. The structures of compounds were established on the basis of IR, 1H NMR, 13C NMR, DEPT, HSQC...
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Devidas SB, Sendri N, Rahmatkar SN, Singh D, Bhandari P Tags: Nat Prod Res Source Type: research

Steroidal saponin from Agave marmorata Roezl modulates inflammatory response by inhibiting NF- κB and AP-1.
Steroidal saponin from Agave marmorata Roezl modulates inflammatory response by inhibiting NF-κB and AP-1. Nat Prod Res. 2020 Dec 21;:1-6 Authors: Cortés A J, Sánchez-Mendoza E, Zamilpa A, González-Cortazar M, Herrera-Ruiz M, Almanza-Pérez JC, Terán-Cabanillas E, Condé R, Domínguez-Ramírez L, Arcos EM, Jiménez-Ferrer JE Abstract Agave marmorata Roezl is an endemic succulent specie from the Oaxaca-Puebla area of Mexico. This plant is a medicinal recourse and contain a rich variety of saponins-type compounds with multiples biological e...
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Cortés A J, Sánchez-Mendoza E, Zamilpa A, González-Cortazar M, Herrera-Ruiz M, Almanza-Pérez JC, Terán-Cabanillas E, Condé R, Domínguez-Ramírez L, Arcos EM, Jiménez-Ferrer JE Tags: Nat Prod Res Source Type: research

Augmented phytotoxic effect of nanoencapsulated ophiobolin A.
This article presents an assessment of the effectiveness of encapsulated ophiobolin A on 11 commonly found weed species, compared to the pure ophiobolin, to the particle alone, and a combination of mixed particles and ophiobolin A, by applying the solution droplets to both intact or injured leaf surface, on the adaxial or abaxial side. The bioassays showed the improved efficacy of the encapsulated ophiobolin, and the need for leaf lesions to diffuse the particles into the tissues. PMID: 33342291 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Vurro M, Townley HE, Morrison R, Boari A, Masi M, Evidente A Tags: Nat Prod Res Source Type: research

Secondary metabolites from Lantana camara L. flowers extract exhibit in  vivo anti-urolithiatic activity in adult Wistar albino rats.
Secondary metabolites from Lantana camara L. flowers extract exhibit in vivo anti-urolithiatic activity in adult Wistar albino rats. Nat Prod Res. 2020 Dec 21;:1-4 Authors: Ezzat MI, El Gendy SN, Saad AS, Abdo WS, El Sayed AM, Elmotayam AK Abstract The present study aims at evaluating potential of the ethanol extracts of L. camara leaves (LE), flowers (FlE) and roots (RE) in the treatment of renal calculi and characterising the secondary metabolites in the active extract. The results revealed that the FlE had significantly reduced the levels of kidney parameters (calcium, creatinine, urea, and ur...
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Ezzat MI, El Gendy SN, Saad AS, Abdo WS, El Sayed AM, Elmotayam AK Tags: Nat Prod Res Source Type: research

Two novel compounds from green walnut husks (Juglans mandshurica Maxim.).
Abstract Phytochemical investigation on the ethanol extract of green walnut husks (Juglans mandshurica Maxim.) led to the isolation of two previously unknown compounds, including a macrolide compound (13S)-8-oxo-(9E, 11E)-8-oxo-octadeca-9,11-dien-13-olide (1) and a diarylheptanoid compound 1-(3'-methoxy-4'-hydroxyphenyl)-7-(3″,4″-dimethoxyphenyl)heptan-3-one (2), together with 19 known compounds. The structures of these 21 compounds were elucidated by extensive analyses of NMR and HR-MS data, and the basis of spectroscopic analysis. PMID: 33342293 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Yang H, Gan C, Guo Y, Qu L, Ma S, Ren Y, Wang X, Wang L, Huang J, Wang J Tags: Nat Prod Res Source Type: research

Six phenanthrenes from the roots of Cymbidium faberi Rolfe. and their biological activities.
Abstract A new phenanthrene compound, 7-(4-hydroxybenzyl)-8-methoxy-9,10- dihydrophenanthrene-2,5-diol (HMD), along with five known compounds (Coelonin, DD, Shancidin, HDP and MDD) were isolated from the roots of Cymbidium faberi Rolfe. (CFR). Their structures were identified using various spectroscopic methods. These compounds were reported for the first time in the genus. All isolated compounds were tested by radical-scavenging ability against 1,1-diphenyl-2-picryl-hydrazyl (DPPH), cytotoxic activity against three human cancer cell lines and inflammatory activity. Among them, Shancidin exhibited the stronger DPP...
Source: Natural Product Research - December 21, 2020 Category: Biochemistry Authors: Lv SS, Fu Y, Chen J, Jiao Y, Chen SQ Tags: Nat Prod Res Source Type: research

3.5-scFv- β-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive.
3.5-scFv-β-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive. Nat Prod Res. 2020 Dec 18;:1-4 Authors: Simonovic M, Mix T, Glumac M, Pejin B Abstract A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of β-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a way the recombinant fusion protein 3.5-scFv-β-lactamase. This bifunctional immunoreage...
Source: Natural Product Research - December 18, 2020 Category: Biochemistry Authors: Simonovic M, Mix T, Glumac M, Pejin B Tags: Nat Prod Res Source Type: research

Two new polyhydroxylated steroidal glycosides from the starfish Culcita novaeguineae.
Abstract The chemical constituent investigation on the starfish Culcita novaeguineae resulted in the isolation of two new polyhydroxylated steroidal glycosides and two known ones. The new compounds were identified as (25S)-3-O-(2-O-methyl-β-D-xylopyranosyl)-26-O-(β-D-xylopyranosyl)-cholest-4-ene-3β,6β,7α,8,15α,16β,26-heptaol (1) and (25S)-3-O-(2-O-methyl-β-D-xylopyranosyl)-26-O-(β-D-xylopyranosyl)-cholest-4,24(28)-diene-3β,6β,7α,8,15α,16β,26-heptaol (2) and the known compounds were determined as linckosides I and H (3-4). The structures of t...
Source: Natural Product Research - December 18, 2020 Category: Biochemistry Authors: Lu YY, Wang MC, Liu K, Zhang W, Liu Y, Tang HF Tags: Nat Prod Res Source Type: research

A new cyclic peptide from the fibrous root of Pseudostellaria heterophylla.
Abstract A new cyclic peptide, Pseudostellarin K (1), together with thirteen known compounds, including two cyclic peptides (2 and 3), one β-carboline alkaloid (4), two amides (5 and 6), three phenylpropanoids (7-9) and other compounds (10-14), were isolated from the fibrous root of Pseudostellaria heterophylla. Their structures were elucidated by extensive spectroscopic analysis. Compounds 1, 4-6, 10 were isolated from the genus pseudostellaria for the first time. All compounds were evaluated for cytotoxic activities against MCF-7, A549, HCT-116 and SGC-7901 cell lines by MTT assay. Unfortunately, all these ...
Source: Natural Product Research - December 17, 2020 Category: Biochemistry Authors: Zhao XF, Zhang Q, Zhao HT, Zhang YD, Liu HR, Yuan LJ, Chen QF Tags: Nat Prod Res Source Type: research

Anti-ulcerogenic potential of anthocyanin-loaded chitosan nanoparticles against alcohol-HCl induced gastric ulcer in rats.
Abstract Chitosan is more prominent in food applications due to its versatile properties. Anthocyanins have gained much research attention due to their multifaceted role in preventing various lifestyle ailments. Encapsulated anthocyanin- loaded chitosan nanoparticles (ACNPs) were prepared by conventional ionotropic gelation method. In the present study, the gastro-protective effect of encapsulated ACNPs was evaluated against absolute ethanol-hydrochloric acid (HCl-Ethanol mixture) induced gastric ulcer in male Wistar rats. The histopathology and microscopic scoring of ulcer data of stomach tissue sections revealed...
Source: Natural Product Research - December 17, 2020 Category: Biochemistry Authors: Perumcherry Raman S, Dara PK, Vijayan DK, Chatterjee NS, Raghavankutty M, Mathew S, Ravishankar CN, Anandan R Tags: Nat Prod Res Source Type: research

A new picrotoxane-type sesquiterpene from Dendrobium nobile Lindl.
Abstract A picrotoxane-type sesquiterpene, dendroterpene E (1), together with five benzene derivatives (2-6), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis. Compound 1 was a new picrotoxane-type sesquiterpene with a C-9/C-1/O/C-11 oxetane ring, which was first encountered in this type of compounds. Compounds 1-3 exhibited inhibitory activities against α-glycosidase. PMID: 33331167 [PubMed - as supplied by publisher] (Source: Natural Product Research)
Source: Natural Product Research - December 17, 2020 Category: Biochemistry Authors: Wang P, Chen X, Cai CH, Kong FD, Huang SZ, Yuan JZ, Xu XL, Mei WL, Dai HF Tags: Nat Prod Res Source Type: research