Xanthine oxidase inhibitory constituents from the roots of < em > Ampelopsis japonica < /em >
Nat Prod Res. 2024 Apr 18:1-10. doi: 10.1080/14786419.2024.2341308. Online ahead of print.ABSTRACTBioassay-guided purification of the xanthine oxidase (XOD) inhibitory extract of the roots of Ampelopsis japonica resulted in the isolation of two new triterpenoids (1-2), designated Ampejaponoside A and B, along with sixteen known compounds (3-18). The structures of Ampejaposide A and B were elucidated by comprehensive analysis of spectroscopic data with the structures of the known compounds 3-18 confirmed by comparison the spectral data with corresponding values reported in literatures. All the isolates were evaluated for th...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Yu-Lin Li Fen Liu Li-Yun Zhao Han-Xiang Li Aikebaier Jumai Zhi-Fang Xu Sheng-Xiang Qiu Source Type: research
Essential oil of < em > Eugenia stictopetala < /em > Mart. ex DC. has antioxidant, antibacterial, and gastrointestinal protective effect
Nat Prod Res. 2024 Apr 18:1-5. doi: 10.1080/14786419.2024.2342556. Online ahead of print.ABSTRACTThis work aimed to investigate the chemical composition, antioxidant capacity, antibacterial activity, and intestinal and gastric protective effects, in addition to the acute toxicity of the essential oil of E. stictopetala (EOEs). (E)-caryophyllene (18.01%), β-pinene (8.84%), and (E)-nerolidol (8.24%), were the components found in higher content in the essential oil. The EOEs showed antioxidant capacity with IC50 values ranging from 220.28 to 283.67 μg/mL, in addition to presenting antibacterial activity against Escherichia ...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Bruno Oliveira de Veras Rianne Ferreira Felix Geovanna Maria de Medeiros Moura Daniela Maria do Amaral Ferraz Navarro J úlio César Ribeiro de Oliveira Farias de Aguiar Almir Gon çalves Wanderley M árcia Vanusa da Silva Maria Tereza Dos Santos Correia Source Type: research
Hemisynthesis and cytotoxic evaluation of manoyl oxide analogs from sclareol: effect of two tertiary hydroxyls & amp; Heck coupling on cytotoxicity
Nat Prod Res. 2024 Apr 18:1-10. doi: 10.1080/14786419.2024.2342558. Online ahead of print.ABSTRACTSclareol, a bioactive diterpene alcohol isolated from Salvia sclarea, was subjected to structural modification and cytotoxic evaluation. Boron-Heck-coupled analogs of manoyl oxide were prepared from sclareol in a two-step reaction scheme. In the first step manoyl oxide was prepared from sclareol using cerium (IV) ammonium nitrate. Further the structural modification of manoyl oxide via Palladium (II) catalysed Boron-Heck coupling reaction produced a new series of compounds. All the synthesised compounds were screened for in vi...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Ifshana Gani Zahidul Islam Sofi Gursimar Kaur Anindya Goswami Khursheed Ahmad Bhat Source Type: research
Enhance the physicochemical properties of the citronella oil -SLNPs to improve the insecticidal activity against < em > Spodoptera littoralis < /em > (Boisd) (Lep. Nactuidae)
Nat Prod Res. 2024 Apr 18:1-17. doi: 10.1080/14786419.2024.2342563. Online ahead of print.ABSTRACTThe Nano-formulation of citronella essential oil (Cymbopogon nardus (L.) and their mixtures of three adjuvants (Provecta®, Top film®, and PEG600-dioleate) were studied to enhance physico-chemical properties of the Nano-formulation and improve the insecticidal effect against Spodoptera littoralis (Boisd). Characterisation of physicochemical properties of Nano-formulation was studied by calculating droplet size, polydispersity index (PDI), and Zeta-potential parameters. The results showed that the Solid Lipid Nanoparticles (SL...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Manal Mohamed Adel Nagwa Yoseif Salem Hany Mohamed Hussein Source Type: research
Oleanolic acid: an antimycobacterial component of < em > Syzygium aromaticum < /em > L. and inhibitor of efflux mediated drug resistance
Nat Prod Res. 2024 Apr 18:1-7. doi: 10.1080/14786419.2024.2343916. Online ahead of print.ABSTRACTOleanolic acid (OA) was isolated from Syzygium aromaticum L. buds, and structurally characterised using different spectroscopic techniques; MS, IR,1H/13C-NMR and 2D NMR experiments. The antimycobacterial activity according to a resazurin microtiter assay (REMA) showed important inhibitory effect of OA on the virulent H37Rv strain, with the lowest minimum concentration of 50 µg/mL, compared to other fractions. Molecular docking of OA with BacA drug efflux pump resulted in good binding affinity of hydrophobic interaction type. T...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Yassine El Ghallab Mohamed Dakir Achraf Aainouss My Driss El Messaoudi Sanae Derfoufi Source Type: research
Saikosaponin a promotes neutrophil extracellular trap formation and bactericidal activity
This study aimed to investigate the effects of SSa, one of the major triterpenoid saponins extracted from Radix bupleuri, on neutrophil extracellular trap (NET) formation and the mechanism associated with this process. Using Sytox green and immunofluorescence assays, we found SSa rapidly induced NET formation, which depended on NADPH oxidase (NOX)-independent ROS production and autophagy. Pharmacologic inhibitor studies indicated that ERK and PI3K/AKT signalling were also required for SSa-induced NET formation, whereas protein arginine deiminase 4 (PAD4) was not required. Furthermore, we found that SSa promoted neutrophil ...
Source: Natural Product Research - April 18, 2024 Category: Biochemistry Authors: Lanqiu Zhang Zhengwei Hu Lei Yang Tianyu Liu Jing Xun Qi Zhang Ximo Wang Hejun Gao Zhongkui Jin Source Type: research
Cyclopeptide alkaloids from the Greek shrub < em > Paliurus spina < /em > - < em > christi < /em > and their < em > in silico < /em > binding affinity to Dipeptidyl Peptidase IV
Nat Prod Res. 2024 Apr 17:1-11. doi: 10.1080/14786419.2024.2340755. Online ahead of print.ABSTRACTA new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and ar...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Vaios Amountzias Dennis Abatis Antonios Drakopoulos Grigoris Zoidis Nektarios Aligiannis Source Type: research
Efficient preparation of icariin from epimedin C by recyclable biphasic enzymatic hydrolysis
This study aimed to develop a sustainable and effective biphasic enzymatic hydrolysis system for the efficient conversion of epimedin C to icariin. The biphasic system was created using butyl acetate and phosphate buffer (pH 4.5) at a ratio of 3:1 (V/V) along with α-L-rhamnosidase/epimedin C (2 U/1 mg) at 50 °C for 12 h. Consequently, 98.21% of epimedin C was hydrolysed to icariin, with 95.62% of the product being transferred to the organic phase. Even after four cycles of use, the conversion ratio remained high at 75.28%. Furthermore, this novel strategy was also used for the conversion of Epimedium brevicornu Maxim. ex...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Wang Chen Yue Zhang Yuhang Zhang Zili Feng Xu He Source Type: research
Two new chemical constituents from the aerial parts of < em > Tripterygium wilfordii < /em >
Nat Prod Res. 2024 Apr 17:1-8. doi: 10.1080/14786419.2024.2342000. Online ahead of print.ABSTRACTTripterygium wilfordii has been historically employed as a conventional botanical insecticide and a plant of medicinal significance. A new dihydroagarofuran sesquiterpene (1) and a new acyclic compound (2), along with seven known compounds (3-9), have been isolated from the aerial parts of Tripterygium wilfordii. The identification of the structures of novel compounds were accomplished through comprehensive spectroscopic analyses, encompassing HRESIMS, NMR, UV, IR, and a comparative analysis with spectroscopic data from compoun...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Xia Zhang Lei Huang Yu-Jun Tang Ya-Lin Hu Wei Xu Hong-Yu Li Yu-Bo Zhang Xiao-Qi Zhang Guang-Xiong Zhou Source Type: research
Dihydrostilbenes from < em > Macaranga javanica < /em > (Blume) M üll. Arg. and their antiplasmodial activity
Nat Prod Res. 2024 Apr 17:1-7. doi: 10.1080/14786419.2024.2342555. Online ahead of print.ABSTRACTAn undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.PMID:38629185 | DOI:10.1080/14786419.2024.2342555 (S...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Tjitjik Srie Tjahjandarie Muhammad Fajar Aldin Ratih Dewi Saputri Mulyadi Tanjung Source Type: research
Antimicrobial secondary metabolites and antioxidant activities of fungal endophytes associated with < em > Ziziphus spina-christi < /em > (L.) Desf. (Nabq) leaves
This study would be one of the first reports to measure the antioxidant activity of Z. spina-christi (L.) Desf. endophytic fungi. Therefore, these isolated endophytic fungi can provide additional information for medicinal sources of natural antioxidants and antimicrobial agents.PMID:38630967 | DOI:10.1080/14786419.2024.2340761 (Source: Natural Product Research)
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Hala Montaser Farouk Eman Zekry Attia Gehan Mohamed Shaban Usama Ramadan Abdelmohsen Mo'men Hamed El-Katatny Source Type: research
Cyclopeptide alkaloids from the Greek shrub < em > Paliurus spina < /em > - < em > christi < /em > and their < em > in silico < /em > binding affinity to Dipeptidyl Peptidase IV
Nat Prod Res. 2024 Apr 17:1-11. doi: 10.1080/14786419.2024.2340755. Online ahead of print.ABSTRACTA new cyclopeptide alkaloid, spinachristene A (1), along with two previously described, sanjoinenine (2) and oxyphylline C (3), were isolated from the fruits of Paliurus spina-christi Mill. All three metabolites are being isolated for the first time from the genus Paliurus. A model for the in silico binding affinity of compounds 1-3 to Dipeptidyl Peptidase IV (DPP4), which is related to type 2 diabetes (T2D), was developed. According to our model, compounds 1-3 were ranked in positions 9/12, 11/12 and 8/12, respectively and ar...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Vaios Amountzias Dennis Abatis Antonios Drakopoulos Grigoris Zoidis Nektarios Aligiannis Source Type: research
Efficient preparation of icariin from epimedin C by recyclable biphasic enzymatic hydrolysis
This study aimed to develop a sustainable and effective biphasic enzymatic hydrolysis system for the efficient conversion of epimedin C to icariin. The biphasic system was created using butyl acetate and phosphate buffer (pH 4.5) at a ratio of 3:1 (V/V) along with α-L-rhamnosidase/epimedin C (2 U/1 mg) at 50 °C for 12 h. Consequently, 98.21% of epimedin C was hydrolysed to icariin, with 95.62% of the product being transferred to the organic phase. Even after four cycles of use, the conversion ratio remained high at 75.28%. Furthermore, this novel strategy was also used for the conversion of Epimedium brevicornu Maxim. ex...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Wang Chen Yue Zhang Yuhang Zhang Zili Feng Xu He Source Type: research
Two new chemical constituents from the aerial parts of < em > Tripterygium wilfordii < /em >
Nat Prod Res. 2024 Apr 17:1-8. doi: 10.1080/14786419.2024.2342000. Online ahead of print.ABSTRACTTripterygium wilfordii has been historically employed as a conventional botanical insecticide and a plant of medicinal significance. A new dihydroagarofuran sesquiterpene (1) and a new acyclic compound (2), along with seven known compounds (3-9), have been isolated from the aerial parts of Tripterygium wilfordii. The identification of the structures of novel compounds were accomplished through comprehensive spectroscopic analyses, encompassing HRESIMS, NMR, UV, IR, and a comparative analysis with spectroscopic data from compoun...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Xia Zhang Lei Huang Yu-Jun Tang Ya-Lin Hu Wei Xu Hong-Yu Li Yu-Bo Zhang Xiao-Qi Zhang Guang-Xiong Zhou Source Type: research
Dihydrostilbenes from < em > Macaranga javanica < /em > (Blume) M üll. Arg. and their antiplasmodial activity
Nat Prod Res. 2024 Apr 17:1-7. doi: 10.1080/14786419.2024.2342555. Online ahead of print.ABSTRACTAn undescribed dihydrostilbene, macajavanicin D (1), and three known analogs, malayheyneiin A (2) and laevifolins A-B (3-4), were isolated from Macaranga javanica (Blume) Müll. Arg. leaves. Macajavanicin D (1) structure was determined based on a combination of ESI-HRMS data and NMR spectra. Compounds 1-4 were evaluated to Plasmodium falciparum strain 3D7. Macajavanicins D (1) and laevifolin A (3) showed potent activity with an IC50 value of 0.85 and 1.03 µg/mL, respectively.PMID:38629185 | DOI:10.1080/14786419.2024.2342555 (S...
Source: Natural Product Research - April 17, 2024 Category: Biochemistry Authors: Tjitjik Srie Tjahjandarie Muhammad Fajar Aldin Ratih Dewi Saputri Mulyadi Tanjung Source Type: research
