Could lactose-free foods influence the gut microbiome?
Nat Prod Res. 2024 Mar 18:1-2. doi: 10.1080/14786419.2024.2325584. Online ahead of print.NO ABSTRACTPMID:38497246 | DOI:10.1080/14786419.2024.2325584 (Source: Natural Product Research)
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Eleonora Di Salvo Nicola Cicero Source Type: research

A lupeol derivative and other isolates with antiplasmodial activity from the stem root of < em > Rauvolfia mannii < /em > Stapf. (Apocynaceae)
Nat Prod Res. 2024 Mar 18:1-5. doi: 10.1080/14786419.2024.2327623. Online ahead of print.ABSTRACTRauvolfia mannii is a plant from western and eastern areas of African continent and is widely used in folk medicine for the treatment of various diseases including malaria. Herein, one previously undescribed acylated triterpene (1), together with five already published natural products (2-6) were removed from its roots. The chemical structures of these compounds were determined by spectroscopic and spectrometric means (NMR, HRESIMS, IR and UV). In addition to the isolated triterpenoids, components 5 and 6 are also newly reporte...
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Fred Alain Zoua Daniela Ntomi Djipmegne Mc J ésus Kinyok Auguste Abouem A Zintchem Andr é Néhémie Bitombo Rostanie Dongmo Zeukang Solenn Ferron Dominique Serge Ngono Bikobo Sophie Tomasi Dieudonn é Emmanuel Pegnyemb Source Type: research

Multiple integrated computational approach to analyse wound healing potential of < em > Symplocos racemosa < /em > bark as Matrix metalloproteinase inhibitors
Nat Prod Res. 2024 Mar 18:1-10. doi: 10.1080/14786419.2024.2321488. Online ahead of print.ABSTRACTThe healing of wounds is the flagging concern in chronic wound cases especially when accompanied by pathogenic, diabetic comorbidities. Matrix metalloproteinases are associated with widespread pathological ailments, and the selective inhibitors for metalloproteinases can be of great interest in wound healing strategies. In the present research study, six constituents of Symplocos racemosa Roxb were evaluated for the docking aptitudes on human matrix metalloproteinase MMP 2 (PDB ID: 1QIB) and MMP 9 (PDB ID: 4H1Q) utilising Auto...
Source: Natural Product Research - March 18, 2024 Category: Biochemistry Authors: Hafiz Abdul Rafey Adnan Amin Samir Anis Ross Mohamed El-Shazly Muhammad Ammar Zahid Shah Iram Niaz Fakhar Ul Mahmood Hammad Ullah Source Type: research

Anti-vibriosis bioactive molecules from marine-derived variant < em > Streptomyces < /em > sp. ZZ741A
In this study, six compounds (1-6) were isolated from the Streptomyces sp. ZZ741A, a marine-derived Streptomyces variant, including one new compound, 2-carbamoylphenyl isobutyrate (1), five known ones, nocardamine (2), dehydroxynocardamine (3), phenylacetic acid (4), thiophenol (5) and 2,3-dihydroxybenzoic acid (6). The anti-vibriosis assay showed that compounds 2 and 3 had specific inhibition activity against Vibrio vulnificus, Vibrio alginolyticus, and Vibrio parahaemolyticus with the MIC values ranging from 8 to 128 μg/mL. The molecular docking study of their possible mechanism of anti-vibriosis activity showed that th...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Di Zhang Yao Feng Mingyi Chu Yujiang Dai Lu Jiang Huifang Li Source Type: research

Effect of < em > Gracilaria changii < /em > extract and its fraction in reverse cholesterol transport by targeting < em > SR-BI < /em > gene
Nat Prod Res. 2024 Mar 14:1-8. doi: 10.1080/14786419.2024.2327851. Online ahead of print.ABSTRACTThis present study aimed to investigate the effects of Gracilaria changii (Red seaweed) extract and its fraction on scavenger receptor class B type I (SR-BI) gene expressions. In vitro studies of the activity of G. changii extract and its fraction against the therapeutic target for hypocholesterolemia were conducted using high-density lipoprotein (HDL) receptor SR-BI via luciferase assay in HepG2 cells. In the current study, methanol crude extract (MCE) and Fraction-2 of G. changii showed the highest expression levels of the SR...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Mohd Rahaizuddin Rani Ahmad Khusairi Azemi Kamariah Bakar Luqman Abu-Bakar Tengku Sifzizul Tengku Muhammad Noraznawati Ismail Source Type: research

Anti-vibriosis bioactive molecules from marine-derived variant < em > Streptomyces < /em > sp. ZZ741A
In this study, six compounds (1-6) were isolated from the Streptomyces sp. ZZ741A, a marine-derived Streptomyces variant, including one new compound, 2-carbamoylphenyl isobutyrate (1), five known ones, nocardamine (2), dehydroxynocardamine (3), phenylacetic acid (4), thiophenol (5) and 2,3-dihydroxybenzoic acid (6). The anti-vibriosis assay showed that compounds 2 and 3 had specific inhibition activity against Vibrio vulnificus, Vibrio alginolyticus, and Vibrio parahaemolyticus with the MIC values ranging from 8 to 128 μg/mL. The molecular docking study of their possible mechanism of anti-vibriosis activity showed that th...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Di Zhang Yao Feng Mingyi Chu Yujiang Dai Lu Jiang Huifang Li Source Type: research

Effect of < em > Gracilaria changii < /em > extract and its fraction in reverse cholesterol transport by targeting < em > SR-BI < /em > gene
Nat Prod Res. 2024 Mar 14:1-8. doi: 10.1080/14786419.2024.2327851. Online ahead of print.ABSTRACTThis present study aimed to investigate the effects of Gracilaria changii (Red seaweed) extract and its fraction on scavenger receptor class B type I (SR-BI) gene expressions. In vitro studies of the activity of G. changii extract and its fraction against the therapeutic target for hypocholesterolemia were conducted using high-density lipoprotein (HDL) receptor SR-BI via luciferase assay in HepG2 cells. In the current study, methanol crude extract (MCE) and Fraction-2 of G. changii showed the highest expression levels of the SR...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Mohd Rahaizuddin Rani Ahmad Khusairi Azemi Kamariah Bakar Luqman Abu-Bakar Tengku Sifzizul Tengku Muhammad Noraznawati Ismail Source Type: research

Anti-vibriosis bioactive molecules from marine-derived variant < em > Streptomyces < /em > sp. ZZ741A
In this study, six compounds (1-6) were isolated from the Streptomyces sp. ZZ741A, a marine-derived Streptomyces variant, including one new compound, 2-carbamoylphenyl isobutyrate (1), five known ones, nocardamine (2), dehydroxynocardamine (3), phenylacetic acid (4), thiophenol (5) and 2,3-dihydroxybenzoic acid (6). The anti-vibriosis assay showed that compounds 2 and 3 had specific inhibition activity against Vibrio vulnificus, Vibrio alginolyticus, and Vibrio parahaemolyticus with the MIC values ranging from 8 to 128 μg/mL. The molecular docking study of their possible mechanism of anti-vibriosis activity showed that th...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Di Zhang Yao Feng Mingyi Chu Yujiang Dai Lu Jiang Huifang Li Source Type: research

Effect of < em > Gracilaria changii < /em > extract and its fraction in reverse cholesterol transport by targeting < em > SR-BI < /em > gene
Nat Prod Res. 2024 Mar 14:1-8. doi: 10.1080/14786419.2024.2327851. Online ahead of print.ABSTRACTThis present study aimed to investigate the effects of Gracilaria changii (Red seaweed) extract and its fraction on scavenger receptor class B type I (SR-BI) gene expressions. In vitro studies of the activity of G. changii extract and its fraction against the therapeutic target for hypocholesterolemia were conducted using high-density lipoprotein (HDL) receptor SR-BI via luciferase assay in HepG2 cells. In the current study, methanol crude extract (MCE) and Fraction-2 of G. changii showed the highest expression levels of the SR...
Source: Natural Product Research - March 15, 2024 Category: Biochemistry Authors: Mohd Rahaizuddin Rani Ahmad Khusairi Azemi Kamariah Bakar Luqman Abu-Bakar Tengku Sifzizul Tengku Muhammad Noraznawati Ismail Source Type: research

Two novel ketone alkaloids from < em > Portulaca oleracea < /em > L. and their anti-inflammatory activities
Nat Prod Res. 2024 Mar 12:1-8. doi: 10.1080/14786419.2024.2325593. Online ahead of print.ABSTRACTEleven compounds were obtained from Portulaca oleracea L., including two novel ketone alkaloids, (1, 2), 4-hydroxy-3-methoxybenzamide (3) (isolated for the first time), β-adenosine (4), oleracrylimide A and B (5, 6), oleracein H, C, D, Q and A (7-11). The two novel ketone alkaloids were identified as 5-acetyl-5-methylcyclopent-2-ene-1-carboxamide (1), named oleraciamide H, and (2 R,3S,4R,5R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yl glycinate (2), named oleracone Q by spectroscopic methods, including 1D, 2D ...
Source: Natural Product Research - March 13, 2024 Category: Biochemistry Authors: Hongzhe Zhang Jing Liu Junjie Yao Fan He Xixiang Ying Source Type: research

Two novel ketone alkaloids from < em > Portulaca oleracea < /em > L. and their anti-inflammatory activities
Nat Prod Res. 2024 Mar 12:1-8. doi: 10.1080/14786419.2024.2325593. Online ahead of print.ABSTRACTEleven compounds were obtained from Portulaca oleracea L., including two novel ketone alkaloids, (1, 2), 4-hydroxy-3-methoxybenzamide (3) (isolated for the first time), β-adenosine (4), oleracrylimide A and B (5, 6), oleracein H, C, D, Q and A (7-11). The two novel ketone alkaloids were identified as 5-acetyl-5-methylcyclopent-2-ene-1-carboxamide (1), named oleraciamide H, and (2 R,3S,4R,5R)-5-((R)-1,2-dihydroxyethyl)-3,4-dihydroxytetrahydrofuran-2-yl glycinate (2), named oleracone Q by spectroscopic methods, including 1D, 2D ...
Source: Natural Product Research - March 13, 2024 Category: Biochemistry Authors: Hongzhe Zhang Jing Liu Junjie Yao Fan He Xixiang Ying Source Type: research

Separation of crude methanol extract of < em > Plantago major < /em > root: identification of phytochemicals and assessment of biological activities
Nat Prod Res. 2024 Mar 12:1-5. doi: 10.1080/14786419.2024.2326993. Online ahead of print.ABSTRACTPlantago major root extracts were used for analysis by Gas Chromatography-Mass Spectrometry (GC-MS). The anticancer and antibacterial functions of extracts were also investigated. The dichloromethane extract of P. major had the highest inhibitory effect against Salmonella paratyphi (18.00 ± 1.4 mm) at 100 mg/mL concentration. The lowest MIC was also achieved for S. paratyphi treated with dichloromethane extract of P. major (1.5 mg/mL). The minimum MBC (2 mg/mL) was observed for dichloromethane extract of P. major root against ...
Source: Natural Product Research - March 12, 2024 Category: Biochemistry Authors: Samaneh Rahamouz-Haghighi Ali Sharafi Source Type: research

Separation of crude methanol extract of < em > Plantago major < /em > root: identification of phytochemicals and assessment of biological activities
Nat Prod Res. 2024 Mar 12:1-5. doi: 10.1080/14786419.2024.2326993. Online ahead of print.ABSTRACTPlantago major root extracts were used for analysis by Gas Chromatography-Mass Spectrometry (GC-MS). The anticancer and antibacterial functions of extracts were also investigated. The dichloromethane extract of P. major had the highest inhibitory effect against Salmonella paratyphi (18.00 ± 1.4 mm) at 100 mg/mL concentration. The lowest MIC was also achieved for S. paratyphi treated with dichloromethane extract of P. major (1.5 mg/mL). The minimum MBC (2 mg/mL) was observed for dichloromethane extract of P. major root against ...
Source: Natural Product Research - March 12, 2024 Category: Biochemistry Authors: Samaneh Rahamouz-Haghighi Ali Sharafi Source Type: research

Antioxidant constituents from < em > Ribes glaciale < /em > Wall.: bioassay targeted < em > in-vitro < /em > and < em > in-silico < /em > evaluation
Nat Prod Res. 2024 Mar 10:1-4. doi: 10.1080/14786419.2024.2326955. Online ahead of print.ABSTRACTBioassay targeted phyto-investigation of dried green walnut husk of Ribes glaciale Wall. yielded one new compound as β-D-glucopyrano (4'→3)-β-D-glucopyranose (1) and four known compounds namely scoparone (2), apigenin (3), β-sitosterol (4) and β-sitosterol-D-glucoside (5). The structure of new compound was elucidated with the help of 1D, 2D and HRESIMS analysis. The antioxidant activity of extract, fractions and pure were evaluated using 2, 2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) (ABTS), 2, 2-diphenyl-1-pic...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: Rajendra Singh Rohit Verma Nitin Sati Waseem Ahmad Ansari Mohammad Faheem Khan Source Type: research

Design, semi-synthesis of soft coral-derived < em > Aspergillus < /em > sp. secondary metabolite geodin derivatives and their antibacterial activities
Nat Prod Res. 2024 Mar 10:1-9. doi: 10.1080/14786419.2024.2326990. Online ahead of print.ABSTRACTA series of novel ester derivatives 2 - 7, of natural product geodin 1, isolated from the soft coral-derived fungus Aspergillus sp., were designed and semi-synthesised through one step reaction with high yield. Compound 5 showed strong antifouling inhibitory activities with MIC of 4.80 μM while compound 4 showed selective inhibitory activities with MICs values 8.59 μM against Aeromonas salmonicida and Pseudomonas aeruginosa (Sea-Nine 211, MIC = 0.27 μM). Compounds 3, 4 and 6 showed potent anti-pathogenic inhibitory activitie...
Source: Natural Product Research - March 11, 2024 Category: Biochemistry Authors: Gulab Said Amjad Ali Latif Ahmad Source Type: research