Interventions to increase research publications in graduate medical education trainees: a systematic review.
Conclusions: Leadership interventions (directors, curricula) are associated with successful GME research efforts. PMID: 30697249 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

A systematic review and meta-analysis of clinical trials investigating the effects of flaxseed supplementation on plasma C-reactive protein concentrations.
Conclusions: The meta-analysis of RCTs did not show a significant change in plasma CRP concentrations following supplementation with various flaxseed products. Large, well-designed studies should be still performed to validate the current results. PMID: 30697250 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Efficacy of serotonin receptor agonists in the treatment of functional dyspepsia: a meta-analysis.
Conclusions: Serotonin receptor agonists had a significantly higher efficacy compared to placebo in the treatment of FD. PMID: 30697251 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Efficacy and safety of various anti-rheumatic treatments for patients with rheumatoid arthritis: a network meta-analysis.
Conclusions: We recommend CZP + MTX as the optimal drug therapy because it has the highest ranking in efficacy outcomes and relatively low risk of adverse events. TCZ + MTX is recommended as an alternative. Abatacept (ABT) and cDMARDs are not recommended due to their low efficacy. PMID: 30697252 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

IgG4-related disease in endocrine practice.
Authors: Rzepecka A, Babińska A, Sworczak K Abstract IgG4-related disease is a set of symptoms resulting from a chronic, usually multiple organ inflammatory condition which affects various organs. It consists of lymphoplasmacytic infiltrations with attendant fibrosis and deep vein thrombosis. Frequently observed tissue lesions are accompanied by elevated IgG4 levels in serum. The etiopathogenesis of the lesions is of multifactor character and the clinical manifestation of the disease is highly diverse. The diagnostic process is based on the patient's medical history, clinical examination and additional tests, incl...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Increased platelet reactivity in dyslipidemic patients with coronary artery disease on dual anti-platelet therapy.
Authors: Jäger B, Piackova E, Haller PM, Andric T, Kahl B, Christ G, Geppert A, Wojta J, Huber K Abstract Introduction: The optimal duration of dual anti-platelet therapy (DAPT) following percutaneous coronary intervention (PCI) is still a matter of debate. Biomarkers may help to identify patients who will benefit from extended DAPT. The aim of the study was to test the interaction between lipid parameters and platelet function in patients with coronary artery disease (CAD) on DAPT. Material and methods: Overall, 58 patients on DAPT were prospectively included following PCI in stable CAD. Platelet markers,...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Soluble urokinase plasminogen activator receptor in one-year prediction of major adverse cardiac events in patients after first myocardial infarction treated with primary percutaneous coronary intervention.
Authors: Wlazeł RN, Migała M, Zielińska M, Pawlicki L, Rośniak-Bąk K, Szadkowska I Abstract Introduction: Soluble urokinase plasminogen activator receptor (suPAR) level reflects the general condition of the organism and was proved to give independent information in risk stratification of patients. The aim of this study was to assess the usefulness of suPAR in the prediction of adverse cardiac events in patients with first myocardial infarction (MI) undergoing primary percutaneous coronary intervention. Additionally, the diagnostic power of suPAR was assessed. Material and methods: One hundred and thirty-ni...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Direct results of a prospective randomized study comparing ablation with the nMARQ catheter and the PVAC catheter used with and without a 3D system (MAPER 3D Study).
Authors: Koźluk E, Piątkowska A, Rodkiewicz D, Peller M, Kochanowski J, Opolski G Abstract Introduction: Our aim was to compare in a prospective randomized study the safety, direct results and periprocedural data of ablation using an nMARQ catheter, a PVAC catheter used with the EnSite system, or a PVAC catheter only under fluoroscopy control. Material and methods: One hundred two patients (70 male, 57 ±11 years) with atrial fibrillation (AF) were prospectively randomized to: group 1 - ablation performed with an nMARQ catheter and the CARTO 3 system; group 2 - a PVAC catheter used with the EnSite syste...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Evaluation of endocan and endoglin levels in chronic kidney disease due to diabetes mellitus.
In this study we evaluated endocan and endoglin levels in diabetes patients with and without albuminuria and compared them with healthy subjects. Therefore we aimed at gaining a better understanding of the role of angiogenesis in diabetic nephropathy and to assess the predictive role of endocan and endoglin as markers of diabetic nephropathy progression. Material and methods: Ninety-six type 2 diabetes patients were classified according to their 24-hour urinary albumin excretion rate. Forty type 2 diabetes patients with normoalbuminuria (urinary albumin excretion
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Oxidative stress markers in patients with hereditary angioedema.
Conclusions: Our observations show additional underlying events involved in HAE and are of central importance for further investigations of differences in bradykinin receptors signaling among the two disease subgroups. PMID: 30697258 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

An evaluation of the usefulness of extracorporeal liver support techniques in patients with severe liver dysfunction.
Conclusions: Further studies are needed to assess the contribution of non-biological extracorporeal liver support procedures to a decrease in mortality rates in the population of patients with severe liver dysfunction. PMID: 30697259 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Evaluation of FGF-19 and β-klotho as biomarkers in patients with intrahepatic cholestasis of pregnancy.
Conclusions: The serum FGF-19 and β-klotho concentrations did not differ between the pregnancies with ICP and the healthy controls. However, in some cases, abnormalities in the FGF-19, β-klotho, and FGFR4 signaling system may play roles in the pathogenesis of ICP. PMID: 30697260 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Lipid levels and selected biomarkers of vascular changes in children with idiopathic headaches - a preliminary report.
Conclusions: Children with headaches have lower total cholesterol and higher BDNF levels than controls. No significant difference in levels of triacylglycerols, HDL cholesterol, LDL cholesterol, VEGF, sCD40L or PAI-1 was found between children with headaches and controls. PMID: 30697261 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Amplitude of low-frequency fluctuations in childhood-onset schizophrenia with or without obsessive-compulsive symptoms: a resting-state functional magnetic resonance imaging study.
Authors: Liang Y, Shao R, Zhang Z, Li X, Zhou L, Guo S Abstract Introduction: Childhood-onset schizophrenia with obsessive-compulsive symptoms (COSO) and without obsessive-compulsive symptoms (COS) share considerable overlap in clinical features and genetic risk factors. However, the extent of brain functional abnormalities in COSO and COS is poorly understood. Material and methods: A total of 51 first-episode childhood schizophrenic patients and 30 healthy age- and sex-matched controls were recruited. We used the Yale-Brown Obsessive Compulsive Scale to divide patients into COSO (n = 21) and COS (n = 30) group...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Prevalence and clinical characteristics of rheumatoid arthritis in Poland: a nationwide study.
Authors: Batko B, Stajszczyk M, Świerkot J, Urbański K, Raciborski F, Jędrzejewski M, Wiland P Abstract Introduction: There are no reliable data regarding the prevalence of rheumatoid arthritis (RA) in Poland. Material and methods: The first stage was a face-to-face survey on a nationwide representative sample of 3000 people, which identified respondents with a physician-confirmed diagnosis of RA. The second stage was a survey of RA patients, which characterized the disease course and treatment. It was evaluated by analysis of a representative group of 1957 RA patients in routine clinical practice. Resul...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures.
This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. Material and methods: This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. The patients were randomly divided into two groups using the method of block randomization including early surgery (within 24 h) and delayed surgery (after 48 h). Serum levels of inflammatory markers in both groups including interleukin (IL)-1, 5, 6, tumor necrosis factor α (TNF-α) and i...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Topical morphine for treatment of cancer-related painful mucosal and cutaneous lesions: a double-blind, placebo-controlled cross-over clinical trial.
Authors: Ciałkowska-Rysz A, Dzierżanowski T Abstract Introduction: Painful mucosal and cutaneous lesions are often less responsive or even refractory to systemic opioid analgesics. There is evidence suggesting that the effectiveness of topical morphine be restricted to inflammatory pain. The studied groups were small and the observation period relatively short. The aim of this study was to assess the effectiveness and safety of topical morphine for pain related to mucosal lesions and skin ulcers. Material and methods: The study was a 14-day randomized placebo-controlled cross-over trial (RCT) with a 28-day fo...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Renin-angiotensin system inhibitor attenuates oxidative stress induced human coronary artery endothelial cell dysfunction via the PI3K/AKT/mTOR pathway.
Authors: Shi X, Guan Y, Jiang S, Li T, Sun B, Cheng H Abstract Introduction: The renin-angiotensin system is associated with blood pressure regulation, inflammation, oxidative stress and insulin resistance. It can decrease intracellular oxidative stress. Stimulation with H2O2 leads to increased oxidative stress and activation of the AKT/mTOR pathway. However, the role of renin-angiotensin system inhibitors in oxidative stress-induced endothelial cell dysfunction and H2O2-induced AKT activation remains unclear. Material and methods: Human coronary artery endothelial cells (HCAECs) were used. The cells were treat...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

FAM40A alters the cytoskeleton of podocytes in familial focal and segmental glomerulosclerosis by regulating F-actin and nephrin.
Authors: Chen Z, Zhang Y, Zhao X Abstract Introduction: Familial focal and segmental glomerulosclerosis (FFSGS) was found in a large cohort of patients in our previous study. Under the sponsorship of the National Natural Science Foundation of China, we conducted linkage analysis and full exon sequencing on the genomes of 54 patients diagnosed with FFSGS. The results revealed a FAM40A gene signature in those patients. To determine whether FAM40A was associated with podocyte lesions and whether changes in the podocyte cytoskeleton could affect podocyte function, mouse podocytes (MPs) were used in this study. Mate...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Antiproliferative and apoptotic activity of glycyrrhizinic acid in MCF-7 human breast cancer cells and evaluation of its effect on cell cycle, cell migration and m-TOR/PI3K/Akt signalling pathway.
Authors: Zhang Z, Feng Y, Li ZY, Cao XZ Abstract Introduction: Glycyrrhizinic acid is a natural product of pharmacological relevance and its anticancer activity against breast cancer cell lines has not been evaluated. Therefore the main purpose of the present study was to investigate the anticancer effects of glycyrrhizinic acid in MCF-7 human breast cancer cells. Material and methods: The MTT assay was used to evaluate the anticancer effects while a clonogenic assay was used to study its effects on colony formation tendency. Flow cytometry was used to study the effects on cell cycle phase distribution and apop...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Roles of miR-210 in the pathogenesis of pre-eclampsia.
This study aimed to explore the bio-function of miR-210 in the pathogenesis of pre-eclampsia and provide new insights into the diagnosis and treatment of pre-eclampsia. Material and methods: A JAR cell line cultured in standard or hypoxic conditions was used in this study. Expression levels of miR-210 and PTPN2 were determined using real-time polymerase chain reaction (RT-PCR). Protein and phosphorylation levels were assessed using western blotting. Proliferation of JAR cells was evaluated using MTT assay. Migration and invasion were measured using transwell assay. Results: Expression of miR-210 increased significa...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

The effect of splenectomy on complement regulatory proteins in erythrocytes in β-thalassemia major.
In this study we investigated how splenectomy effects complement regulatory system in erythrocytes. We analysed CD35, CD55, and CD59 levels on erythrocytes in β-TM by flow cytometry. Results: The overall mean percentage of CD55 and CD35 positive RBCs of group 1 (22 β-TM with splenectomy) was significantly lower than group 2 (23 β-TM without splenectomy) and group 3 (healthy controls) (p
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Stilbene glycoside protects osteoblasts against oxidative damage via Nrf2/HO-1 and NF- κB signaling pathways.
Conclusions: THSG could significantly attenuate oxidative damage induced by H2O2 via the Nrf2/NF-κB signaling pathway, providing new insights for treatments of osteoporosis induced by oxidative injury. PMID: 30697271 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Trichostatin A activates FOXO1 and induces autophagy in osteosarcoma.
Conclusions: We found that inhibition of autophagy, either by autophagy inhibitors or ATG gene knockdown, markedly enhances TSA-caused cell death. Taken together, our studies reveal the function of autophagy in HDACI-caused osteosarcoma cell death and thus support the development of a novel therapeutic strategy by combining HDACIs and autophagy inhibitors in osteosarcoma treatment. PMID: 30697272 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

BDNF contributes to the skeletal muscle anti-atrophic effect of exercise training through AMPK-PGC1 α signaling in heart failure mice.
In this study, we tested whether exercise training would counteract skeletal muscle atrophy via activation of the BDNF pathway in myocardial infarction (MI)-induced HF mice. Material and methods: A cohort of male Sham-operated and MI mice were assigned into 8-week moderate exercise training, and untrained counterparters were used as control. Exercise capacity, plasma norepinephrine (NE) level, heart rate (HR), fractional shortening (FS) and ejection fraction (EF) were measured. The protein expression of BDNF, p-TrkB, p-AMPK and PGC1α were analyzed by Western blot. Results: Compared with the Sham-operated mice...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

In vivo effect of Piper sarmentosum methanolic extract on stress-induced gastric ulcers in rats.
Authors: Azlina MFN, Qodriyah HMS, Akmal MN, Ibrahim IAA, Kamisah Y Abstract Introduction: Piper sarmentosum (Piperaceae) is traditionally used by Asians to treat numerous common ailments including asthma, fever and gastritis. The aim of the research was to determine and compare the effects of Piper sarmentosum (PS) with omeprazole (OMZ) on gastric parameters in rats exposed to restraint stress. Material and methods: The methanolic extract of PS was prepared in the dose of 500 mg/kg. Twenty-eight male Wistar rats were assigned to 4 equal sized groups: two control groups and two treated groups which were supplem...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Ethyl pyruvate treatment ameliorates pancreatic damage: evidence from a rat model of acute necrotizing pancreatitis.
Authors: Turkyilmaz S, Cekic AB, Usta A, Alhan E, Kural BV, Ercin C, Sağlam K Abstract Introduction: Ethyl pyruvate (EP), a natural flavoring and fragrance agent, has been shown to exert anti-inflammatory and antioxidant actions. We tested the potential beneficial effects of EP in a rat model of acute necrotizing pancreatitis (ANP), a serious condition with a significant inflammatory explosion and oxidative stress. Material and methods: Fifty-two adult male Sprague-Dawley rats were divided into four groups: sham + saline, sham + EP, ANP + saline, and ANP + EP. The ANP was induced by glycodeoxycholic acid and c...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

In vivo administration of quercetin ameliorates sperm oxidative stress, inflammation, preserves sperm morphology and functions in streptozotocin-nicotinamide induced adult male diabetic rats.
In this study, in-vivo effects of quercetin on sperm parameters in DM were investigated. Material and methods: Quercetin (10, 25 and 50 mg/kg/b.w.) was given orally to streptozotocin-nicotinamide induced adult male diabetic rats for 28 days. Following treatment completion, rats were sacrificed and sperm were harvested from the cauda epididymis. Sperm count, motility, viability, hyperosmotic swelling (HOS) tail-coiled sperm and morphology were assessed. Levels of lipid peroxidation (LPO) and anti-oxidative enzymes (SOD, CAT and GPx) in sperm with and without H2O2 incubation were determined by biochemical assays. Express...
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Potential injurious effects of the fine particulate PM2.5 on the progression of atherosclerosis in apoE-deficient mice by activating platelets and leukocytes.
Conclusions: PM2.5 exposure activated circulating leukocytes, platelets and associated inflammatory factors, contributing to the progression of atherosclerosis in apoE-/- mice. PMID: 30697277 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Pulmonary hypertension in left heart disease.
Authors: Mehra P, Mehta V, Sukhija R, Sinha AK, Gupta M, Girish MP, Aronow WS PMID: 30697278 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 1, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Prevalence of childhood and adolescent overweight and obesity in Asian countries: a systematic review and meta-analysis.
Authors: Mazidi M, Banach M, Kengne AP, Lipid and Blood Pressure Meta-analysis Collaboration Group Abstract Introduction: We conducted a systematic review and meta-analysis to estimate the prevalence of overweight and obesity in children (aged 5-12 years) and adolescents (aged 12-19 years) in Asian countries. Study design: Systematic review and meta-analysis. Material and methods: We comprehensively searched specialised databases for relevant studies conducted in Asian countries between January 1, 1999, and May 30, 2017. Random effects models (using the DerSimonian-Laird method) and generic inverse variance met...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Association of interleukin-17a rs2275913 gene polymorphism and asthma risk: a meta-analysis.
Conclusions: The results of this meta-analysis indicate that the G allele of rs2275913 in IL-17A is a protective factor for the development of asthma. PMID: 30393475 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Genetic polymorphisms of MBL2 and tuberculosis susceptibility: a meta-analysis of 22 case-control studies.
In this study, a meta-analysis of 22 case-control studies was carried out to assess the effect of MBL2 polymorphisms on tuberculosis risk. Material and methods: A search was performed in Embase, PubMed and Web of Science up to Sep 30, 2015. Odds ratio (OR) and 95% confidence interval (95% CI) were used to assess the association. Statistical analyses were performed using STATA 12.0 software. Results: rs1800451 was associated with a decreased tuberculosis risk in the allele model (C vs. A: OR = 0.93, 95% CI: 0.86-1.00, p = 0.050). In analyses stratified by ethnicity, rs7096206 (C/G: OR = 1.31, 95% CI: 1.10-1.57, p = ...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Association of non-alcoholic fatty liver disease with cardiovascular disease and subclinical atherosclerosis.
Authors: Sao R, Aronow WS Abstract Non-alcoholic fatty liver disease (NAFLD) refers to fatty infiltration of liver in the absence of significant alcohol intake, use of steatogenic medication, or hereditary disorders. It is a common cause of chronic liver disease with a worldwide estimated prevalence ranging from 6.3% to 33%. The NAFLD is considered a hepatic manifestation of the metabolic syndrome. Insulin resistance and increased oxidative stress are central to pathogenesis of NAFLD, and risk factors include metabolic syndrome, diabetes mellitus, obesity, lack of physical activity, smoking, and high fat diet. NAFL...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Viral genome changes and the impact of viral genome persistence in myocardium of patients with inflammatory cardiomyopathy.
Conclusions: A decrease in the number of positive PCR findings in control endomyocardial biopsy was observed. Viral genome persistence was not associated with worse outcome in short-term follow-up. PMID: 30393478 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Immunoexpression of DNA fragmentation factor 40, DNA fragmentation factor 45, and B-cell lymphoma 2 protein in normal human endometrium and uterine myometrium depends on menstrual cycle phase and menopausal status.
Conclusions: The study provides important evidence regarding menstrual cycle-dependent changes in the expression of DFF40, DFF45 and Bcl-2 in the normal human endometrium, especially in the glandular layer, and shows that their levels are stable in the normal uterine myometrium. PMID: 30393479 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

LncRNA myocardial infarction-associated transcript promotes cell proliferation and inhibits cell apoptosis by targeting miR-330-5p in epithelial ovarian cancer cells.
Authors: Shao S, Tian J, Zhang H, Wang S Abstract Introduction: Long non-coding RNAs (lncRNAs) have been shown to have great importance in cancer development and progression. However, the mechanism of lncRNAs in epithelial ovarian cancer remains unclear. In the present study, we aimed to explore the role of the lncRNA myocardial infarction-associated transcript (MIAT) in epithelial ovarian cancer tumorigenesis. Material and methods: Quantitative real-time PCR (qRT-PCR) was used to determine MIAT expression in human epithelial ovarian cancer tissues and cell lines, and the effects of MIAT on cell proliferation a...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Surface CD200 and CD200R antigens on lymphocytes in advanced gastric cancer: a new potential target for immunotherapy.
Authors: Zgodziński W, Grywalska E, Surdacka A, Zinkiewicz K, Majewski M, Szczepanek D, Wallner G, Roliński J Abstract Introduction: Gastric cancer (GC) is one of the leading causes of cancer death worldwide. The membrane glycoprotein CD200, widely expressed on multiple cells/tissues, uses a structurally similar receptor (CD200R), delivering immunoregulatory signals. There is evidence that CD200/CD200R signaling suppresses anti-tumor responses in different types of malignancies. Little is known about the CD200/CD200R pathway in GC. The aim of the study was to evaluate the frequencies of CD200+ and CD200R+ lymphoc...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Inositol-6 phosphate inhibits the mTOR pathway and induces autophagy-mediated death in HT-29 colon cancer cells.
Conclusions: Our results clearly indicate that IP6 induces autophagy by inhibiting the Akt/mTOR pathway. PMID: 30393482 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

PAQR3 inhibits proliferation via suppressing PI3K/AKT signaling pathway in non-small cell lung cancer.
Authors: Li X, Li M, Chen D, Shi G, Zhao H Abstract Introduction: Lung cancer is the leading cause of cancer-related death worldwide and non-small cell lung cancer (NSCLC) accounts for approximately 85% of all lung cancer cases. PAQR (progestin and adipoQ receptor family) 3, a Golgi-anchored membrane protein, has been demonstrated to act as a tumor suppressor in multiple cancers. However, the expression and role of PAQR3 have never been explored in NSCLC. The purpose of this study was to investigate the expression and role of PAQR3 in NSCLC. Material and methods: Expression of PAQR3 at mRNA and protein levels w...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Efficacy of brain radiotherapy plus EGFR-TKI for EGFR-mutated non-small cell lung cancer patients who develop brain metastasis.
Conclusions: Our research indicated that delayed brain RT may result in inferior iPFS in EGFR mutated NSCLC patients with asymptomatic brain metastases, but no OS benefit was obtained. In addition, our study revealed that patients treated with SRS had a significantly longer OS for symptomatic BM. Future prospective study of the optimal management strategy with WBRT or SRS and TKI for this patient cohort is urgently needed. PMID: 30393484 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The function and clinical relevance of lncRNA UBE2CP3-001 in human gliomas.
Authors: Luo Z, Pan J, Ding Y, Zhang YS, Zeng Y Abstract Introduction: Gliomas are the most frequent primary tumors in the human brain. Recent studies have identified a class of long noncoding RNAs, named lncRNAs, which were reported to participate in regulating the development of various diseases, including gliomas. In our previous studies, we found that lncRNA UBE2CP3-001 was overexpressed in gliomas but not in normal tissue. However, the molecular functions of UBE2CP3-001 in glioma are largely unknown. Material and methods: The presence of UBE2CP3-001 in U87 cells, glioma tissues and normal brain tissues was...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

MiR-216b inhibits pancreatic cancer cell progression and promotes apoptosis by down-regulating KRAS.
In this study, we explore how miR-216b affected human pancreatic cancer cell development by targeting KRAS. Material and methods: Expression level of miR-216b and KRAS in tissue samples and cells were detected by RT-PCR and western blot. Immunohistochemical assay analysed the expressions of KRAS protein in tumor and adjacent tissues. The target relationship between miR-216b and KRAS was validated by dual-luciferase reporter assay. Pancreatic cancer cell proliferation, migration, invasion and apoptosis abilities of cells transfected with miR-216b mimics and KRAS-siRNA, Panc-1 were detected by MTT assay, transwell assay ...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Down-regulation of miR-203a by lncRNA PVT1 in multiple myeloma promotes cell proliferation.
Authors: Yang M, Zhang L, Wang X, Zhou Y, Wu S Abstract Introduction: Emerging evidence has indicated that long non-coding RNAs (lncRNAs) play vital roles in multiple myeloma (MM) development and progression. However, the underlying mechanism of PVT1 in MM remains unclear. Material and methods: QRT-PCR was used to detect the expression of PVT1 and miR-203a in MM samples and cell lines. The effects of PVT1 on MM cell proliferation and apoptosis were determined by CCK8 assay and flow cytometer assay, respectively. Bioinformatics methods were used to identify the downstream target miRNAs of PVT1. Results: We f...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF-1 α, and COL2A1 gene expression.
Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF-1α, and COL2A1 gene expression. Arch Med Sci. 2018 Oct;14(6):1340-1347 Authors: Sirin DY, Karaarslan N Abstract Introduction: The aim of the present study is to investigate the effects of pregabalin (PGB) on chondrocyte proliferation and collagen type II (COL2A1), hypoxia-inducible factor 1-α (HIF-1α), and chondroadherin (CHAD) gene expression in osteoarthritic chondrocytes. Material and methods: Standard primary chondrocyte cultures were prepared using osteochondral tissues that were surgically obt...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Expression of recombinant allergen, Der f 1, Der f 2 and Der f 4 using baculovirus-insect cell systems.
Conclusions: Recombinant allergens from dust mites can be successfully generated using a baculovirus-insect expression system. Furthermore, these recombinant allergens can be used to detect mite sensitivity in sera, highlighting their utility in future work to understand and develop treatment for mite allergy. PMID: 30393489 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Is subclinical atherosclerosis associated with visceral fat and fatty liver in adolescents with type 1 diabetes?
Authors: Atwa H, Gad K, Hagrasy H, Elkelany A, Azzam M, Bayoumi N, Gobarah A, Shora H Abstract Introduction: There is a 3-fold higher prevalence of cardiovascular complications in patients with type 1 diabetes. The aim was to assess the relationship between subclinical atherosclerosis and visceral fat and fatty liver in diabetic adolescents. Material and methods: The study was performed on 110 adolescents with type 1 diabetes (T1D) attending the Pediatric Diabetes Clinic of the University Hospital, Ismailia, Egypt. Their mean age was 14.2 ±0.7 years with a mean duration of diabetes 6 ±0.3 years. T...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Association of common polymorphisms in the VEGFA and SIRT1 genes with type 2 diabetes-related traits in Mexicans.
Conclusions: Rigorous analysis evidenced the association of VEGFA rs2010963 and SIRT1 rs7896005 with HDL-C and DBP respectively; these traits are known predictors of cardiovascular complications, which increase the risk of cardiovascular diseases in this population. PMID: 30393491 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Arterial stiffness is associated with target organ damage in subjects with pre-hypertension.
Authors: Wu S, Chen D, Zeng X, Wen J, Zhou C, Xiao K, Hu P, Chen W Abstract Introduction: Present study was to evaluate whether increased arterial stiffness was associated with target organ damage in pre-hypertensive subjects. Material and methods: Pre-hypertensive subjects enrolled and echocardiography was used to evaluate left ventricular hypertrophy (LVH) and the first morning urine was collected to evaluate albumin and creatinine ratio (ALB/Cr ratio). Carotid-femoral pulse wave velocity (cf-PWV) was measured. Results: A total of 420 subjects were recruited and mean age was 42.6 years. Mean systolic/dias...
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, N-acetyl- β-D-glucosaminidase levels and mortality risk in septic patients with acute kidney injury.
Conclusions: In severe septic AKI patients, high levels of NGAL, KIM-1 and NAG are associated with mortality risk scores. Urinary NGAL, KIM-1 and NAG concentrations higher than 102.5 ng/ml, 7.3 ng/ml and 15.4 U/l respectively may be used to predict increased of death risk scores. PMID: 30393493 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 6, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research