Outcomes of transition from premixed and intensive insulin therapies to insulin aspart/degludec co-formulation in type 2 diabetes mellitus: a real-world experience.
Conclusions: The current analysis indicates that IDegAsp treatment improves outcomes, with the most notable differences observed in daily total insulin requirement, body mass, and hypoglycaemia. PMID: 33488849 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Plasma renin activity, serum aldosterone concentration and selected organ damage indices in essential arterial hypertension.
Conclusions: Assessment of the influence of the renin-angiotensin-aldosterone system (RAAS) on AOD should include the relationship between renin and aldosterone. The PRA itself has no predictive value for AOD. More advanced arterial stiffness and renal impairment are associated with increased PRA and ARR. The RAAS activity might be useful in AOD prediction and hypertension severity assessment. PMID: 33488850 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Atrial fibrillation risk factors in patients with ischemic stroke.
In this study we found - based on a univariable and multivariable logistic regression model - that compared to the patients with IS without AF, the group of patients which suffered from IS with nonvalvular atrial fibrillation (NVAF) had a higher proportion of patients who smoked cigarettes (OR = 15.742, p
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Systolic stretching of the ascending aorta.
The objective of this study was to assess longitudinal systolic stretching of the aorta and its correlation with the diameters of the ascending aorta and the aortic root. Material and methods: Aortographies of 122 patients were analyzed. The longitudinal systolic stretching of the aorta caused by the contraction of the heart during systole and the maximum dimensions of the aortic root and ascending aorta were measured in all patients. Results: The maximum dimension of the aortic root was on average 34.9 ±4.5 mm and the mean diameter of the ascending aorta was 33.9 ±5.4 mm. The systolic aortic stretchi...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Effect of interactions between APOE and ESR1 polymorphisms on cognitive functions in postmenopausal women.
Conclusions: Interactions of polymorphic variants of APOE and ESR1 genes influenced cognitive functions in postmenopausal women. PMID: 33488853 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Relationship between age and in-hospital mortality during 15,345,025 non-surgical hospitalizations.
Conclusions: The in-hospital non-surgery-related mortality rate was approximately 4%. It significantly increased with age and, regardless of age, was highest in patients suffering from respiratory diseases. PMID: 33488854 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Urinary netrin-1 concentration in healthy full-term newborns.
Conclusions: This is the first study showing the urinary netrin-1 concentration in healthy full-term newborns. Future investigation is needed to confirm its potential role as a marker of kidney function in this age group. PMID: 33488855 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Blood bioactive sphingolipids in patients with advanced serous epithelial ovarian cancer - mass spectrometry analysis.
Conclusions: Plasma concentrations of C16, C18.1 and C18 correlated with the progression of ovarian cancer (FIGO staging and grading). Plasma levels of C16-Cer and C18:1-Cer and erythrocyte C18:1-Cer levels could be used to distinguish patients with advanced serous ovarian cancer. PMID: 33488856 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Risk factors, types and outcomes of arterial ischemic stroke in Polish pediatric patients: a retrospective single-center study.
Conclusions: The presence and number of neurological outcomes depend on stroke subtypes. A relation between the presence of post-stroke deficits and age at onset was observed. The odds of deficit after ischemic stroke decreases by an average of 10.6% if the child is 1 year older at the time of AIS. PMID: 33488857 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Usefulness of three-dimensional echocardiography for assessment of left and right ventricular volumes in children, verified by cardiac magnetic resonance. Can we overcome the discrepancy?
Authors: Kamińska H, Małek ŁA, Barczuk-Falęcka M, Werner B Abstract Introduction: The role of three-dimensional echocardiography (3D-ECHO) chamber quantification in children is still underestimated. Material and methods: In 43 children 3D-ECHO measurements of end-diastolic (EDV) and end-systolic ventricular volumes (ESV) were compared to cardiac magnetic resonance (CMR) using Bland-Altman analysis and linear regression. The values of left and right ventricular volumes calculated in 3D-ECHO were compared with each other and verified by CMR. Results: The values of LV-EDV and LV-ESV measured in 3D-ECHO sho...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Health-related quality of life in children with immunoglobulin A nephropathy - results of a multicentre national study.
Authors: Mizerska-Wasiak M, Adamczuk D, Cichoń-Kawa K, Miklaszewska M, Szymanik-Grzelak H, Pietrzyk JA, Pukajło-Marczyk A, Zwolińska D, Rybi-Szumińska A, Wasilewska A, Bieniaś B, Sikora P, Firszt-Adamczyk A, Stankiewicz R, Szczepańska M, Pańczyk-Tomaszewska M Abstract Introduction: Immunoglobulin A nephropathy (IgAN) may lead to end stage renal disease and severely affect patient functioning and wellbeing. The aim of the study was to evaluate health-related quality of life (HRQoL) in children and adolescents with IgAN, and compare HRQoL in relation to the disease course, social status and psychological facto...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Tumor necrosis factor α, protein gene product 9.5, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 presence in congenital intra-abdominal adhesions in children under one year of age.
Conclusions: The positive correlation between the immunoreactive structures for TNF-α and PGP 9.5 suggests that nerve in-growth into intraabdominal adhesions might be induced by TNF-α and PGP 9.5 could have a role in maintaining inflammation. The down-regulation of PGP 9.5 suggests that pathogenesis of congenital intraabdominal adhesions may be related to hypoxia induced damage. The imbalance between MMP-2 and TIMP-2 may prove tissue fibrosis as a response to congenital peritoneal adhesions. PMID: 33488860 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Urate crystal deposition in hyperuricemic children: a dual energy computed tomography study.
Conclusions: Urate deposition can occur in children with HUA, and these deposits occur more frequently in hyperuricemic children with a history of arthritis symptoms. Also, the urate deposition in the first MTP joint and calcaneus was more prevalent than in other joints. It is important to give more attention to hyperuricemic children. PMID: 33488861 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Time efficiency of direct anterior hip arthroplasty compared to postero-lateral approach in elderly patients.
Authors: Skowronek P, Wojciechowski A, Wypniewski K, Sibiński M, Polguj M, Maksymiuk-Kłos A, Piątkiewicz P Abstract Introduction: Primary arthroplasty of the hip joint is currently one of the most commonly performed procedures in orthopedics. In Poland we are observing significant changes in the age structure. With the prolonged life more and more elderly patients require musculoskeletal surgery to maintain comfortable and painless mobility. Reducing the duration of the procedure reduces the costs of anesthesiology, surgical and instrument teams, as well as the operating room technical team. The aim of the study...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Use of O-arm with neuronavigation in percutaneous vertebroplasty reduces the surgeon's exposure to intraoperative radiation.
Conclusions: During vertebroplasty with the O-arm combined with neuronavigation the radiation dose is significantly lower as compared with the C-arm used for fluoroscopic guidance, minimizing the potential risk of radiation exposure to surgeons. PMID: 33488863 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Serum interleukin-23 protects, whereas methotrexate treatment stimulates selected components of the metabolic syndrome in patients with SAPHO syndrome.
Conclusions: Serum IL-23 protects, whereas methotrexate treatment stimulates selected components of the MetS in patients with SAPHO syndrome. PMID: 33488864 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

MicroRNA-101 inhibits growth and metastasis of human ovarian cancer cells by targeting PI3K/AKT.
Conclusions: It can be concluded that miRNA-101 acts as a tumor suppressor which may be beneficial in the treatment of ovarian cancer. PMID: 33488865 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

DEK overexpression is predictive of poor prognosis in esophageal squamous cell carcinoma.
In this study, our aim was to investigate DEK protein expression and its relationship with clinicopathological parameters and prognosis in esophageal squamous cell carcinoma (ESCC). Material and methods: Tissue samples were collected from 120 routinely diagnosed ESCC patients who underwent surgical resection at the Zhongshan Hospital, Xiamen University in the period from June 2011 to May 2013. The expression of DEK was determined by immunohistochemistry. Results: DEK protein was ubiquitously distributed in the nucleus of ESCC cells, and its positive rate (71.7%) was significantly higher in cancer samples than those...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Comprehensive analysis of key lncRNAs in HCV-positive hepatocellular carcinoma.
Conclusions: We believe that this study can provide novel potential therapeutic and prognostic biomarkers for HCV-positive HCC. PMID: 33488867 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

CNTN-1 promotes docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer.
Conclusions: The results of the present study suggest that downregulation of CNTN-1 may be an important mechanism to reverse chemoresistance in Dox-resistant PCa progression, thus shedding light on the development of novel anti-tumor therapeutics for the treatment of PCa. PMID: 33488868 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Resveratrol is cytotoxic and acts synergistically with NF- κB inhibition in osteosarcoma MG-63 cells.
Resveratrol is cytotoxic and acts synergistically with NF-κB inhibition in osteosarcoma MG-63 cells. Arch Med Sci. 2021;17(1):166-176 Authors: Xu N, Wang L, Fu S, Jiang B Abstract Introduction: Osteosarcoma is the most common primary malignancy of the bone. The existing adjuvant chemotherapy regimens, while improving the overall survival, have been limited by the significant systemic toxicity. Substantial clinical and research efforts are being invested to develop novel pharmaceutical agents. Resveratrol (Res) has been suggested to have a chemopreventive effect. However, the mechanism of Res in o...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

IFN- γ +874 A > T (rs2430561) gene polymorphism and risk of pulmonary tuberculosis: a meta-analysis.
Conclusions: In conclusion, the IFN-γ +874 A>T gene polymorphism is significantly associated with reduced risk of PTB, showing a protective effect in the overall and in the Caucasian population. However, this polymorphism is not associated with PTB risk in the Asian population. PMID: 33488870 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Molecular economy of nature with two thyrotropins from different parts of the pituitary: pars tuberalis thyroid-stimulating hormone and pars distalis thyroid-stimulating hormone.
Authors: Ertek S Abstract Thyrotropin (TSH) is classically known to be regulated by negative feedback from thyroid hormones and stimulated by thyrotropin-releasing hormone (TRH) from the hypothalamus. At the end of the 1990s, studies showed that thyrotroph cells from the pars tuberalis (PT) did not have TRH receptors and their TSH regulation was independent from TRH stimulation. Instead, PT-thyrotroph cells were shown to have melatonin-1 (MT-1) receptors and melatonin secretion from the pineal gland stimulates TSH-β subunit formation in PT. Electron microscopy examinations also revealed some important differen...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The role of innate lymphoid cells in selected disease states - cancer formation, metabolic disorder and inflammation.
Authors: Poniewierska-Baran A, Tokarz-Deptuła B, Deptuła W Abstract Innate lymphoid cells (ILCs) are a recently described group of immune cells that can regulate homeostasis and protect mammalian organisms, including humans, from infections and diseases. Considering this, ILC research is still ongoing to better understand the biology of these cells and their roles in the human body. ILCs are a multifunctional group of immune cells, making it important for the medical community to be familiar with the latest research about the ILC families and their functions in selected disease states, such as cancer formation, m...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review.
Authors: Starzyńska A, Sejda A, Adamska P, Marvaso G, Sakowicz-Burkiewicz M, Adamski Ł, Jereczek-Fossa BA Abstract Over 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually worldwide. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new molecular markers may be of use in prevention, prognosis, and choice of an appropriate therapy. The intracellular molecular signalling pathway of phosphatidyl-inositol-3-kinase is involved in the process of cell growth, differentiation, migration, and survival. The main components of this pathway: PIK3CA (...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model.
Conclusions: Although the two tested doses of nanoparticulate curcumin were much lower than free curcumin, both doses were effective in preventing HCC development while the low dose of free curcumin was hardly effective. Hence, we conclude that nanoparticles enhance the bioavailability of curcumin. PMID: 33488874 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The decrease in hippocampal transient receptor potential M2 (TRPM2) channel and muscarinic acetylcholine receptor 1 (CHRM1) is associated with memory loss in a surgical menopause rat model.
Authors: Pala S, Atilgan R, Kuloglu T, Yalçın E, Kaya N, Etem E Abstract Introduction: The aim of the study was to investigate the association of transient receptor potential M2 (TRPM2) channel and muscarinic acetylcholine receptor 1 (CHRM1) activity with the memorial functions that are deteriorated in surgical menopause. Material and methods: A total of 14 female rats were randomly divided into 2 groups: group (G)1: sham group; group (G)2: surgical menopause group, the group in which bilateral ovariectomy was performed. Fourteen days after the surgical procedure, learning and memorial tests were perfor...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The value of potassium, pH and D-dimer levels in early diagnosis of acute mesenteric ischemia: an experimental study on rats.
This study was conducted at the Istanbul University Center of Experimental Medicine after having received approval from the Istanbul University animal testing ethics committee. Male albino Wistar rats (n = 24; 250 to 350 g) were divided into two control groups and two ischemic groups. Levels of potassium, pH, and D-dimer in blood and levels of potassium and pH in peritoneal lavage fluid were analyzed for 1 h and 2 h after the induced acute mesenteric ischemia procedure. The degree of ischemic injury was determined using the histopathological damage score in tissue samples taken from the terminal ileum. Results: Ischemi...
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

PCSK9 genetic variants and cognitive abilities: a large-scale Mendelian randomization study.
Conclusions: We are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors. PMID: 33488877 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Safety, efficacy, length of stay and patient satisfaction with outpatient management of low-risk pulmonary embolism patients - a meta-analysis.
Conclusions: In conclusion, our meta-analysis of 2 randomized controlled trials shows that low-risk pulmonary embolism patients can safely be discharged from the emergency departments in the limited studies available. We need more randomized controlled trials to confirm these findings. PMID: 33488878 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Serum inflammatory markers in the diagnosis and assessment of Crohn's disease activity.
Conclusions: Serum CRP may be useful in the assessment of CD activity and there is a need for introduction of IL-23 for the CD diagnosis. PMID: 33488879 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Decreased interleukin-35 levels and CD4+EBI3+ T cells in patients with type 1 diabetes and the effects of the antibody against CD20 (rituximab).
Authors: Ouyang H, Wen J, Song K PMID: 33488880 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Role of the interleukin-17 pathway in the pathogenesis of atrial fibrillation associated with inflammation.
Authors: Yue H, Gu J, Zhao X, Liang W, Wu Z PMID: 33488881 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Mesenchymal soluble factors confer imatinib drug resistance in chronic myelogenous leukemia cells.
Authors: Regev O, Kidan N, Nicola M, Khamisie H, Ruthardt M, Mahajna J PMID: 33488882 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 27, 2021 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Outcomes of transition from premixed and intensive insulin therapies to insulin aspart/degludec co-formulation in type 2 diabetes mellitus: a real-world experience
CONCLUSIONS: The current analysis indicates that IDegAsp treatment improves outcomes, with the most notable differences observed in daily total insulin requirement, body mass, and hypoglycaemia.PMID:33488849 | PMC:PMC7811302 | DOI:10.5114/aoms.2020.93264 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Serhat Özçelik Mehmet Çelik A şkı Vural B ünyamin Aydın Melike Özçelik Hulya Gozu Source Type: research

Relationship between age and in-hospital mortality during 15,345,025 non-surgical hospitalizations
CONCLUSIONS: The in-hospital non-surgery-related mortality rate was approximately 4%. It significantly increased with age and, regardless of age, was highest in patients suffering from respiratory diseases.PMID:33488854 | PMC:PMC7811322 | DOI:10.5114/aoms/89768 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Magdalena Walicka Monika Puzianowska-Kuznicka Marcin Chlebus Andrzej Śliwczyński Melania Brzozowska Daniel Rutkowski Lidia Kania Marcin Czech Andrzej Jacyna Edward Franek Source Type: research

Urinary netrin-1 concentration in healthy full-term newborns
CONCLUSIONS: This is the first study showing the urinary netrin-1 concentration in healthy full-term newborns. Future investigation is needed to confirm its potential role as a marker of kidney function in this age group.PMID:33488855 | PMC:PMC7811309 | DOI:10.5114/aoms/89591 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Monika Kamianowska Marek Szczepa ński El żbieta E Kulikowska Barbara Bebko Alicja Koput Anna Wasilewska Source Type: research

Health-related quality of life in children with immunoglobulin A nephropathy - results of a multicentre national study
Arch Med Sci. 2020 Nov 24;17(1):84-91. doi: 10.5114/aoms.2020.100367. eCollection 2021.ABSTRACTINTRODUCTION: Immunoglobulin A nephropathy (IgAN) may lead to end stage renal disease and severely affect patient functioning and wellbeing. The aim of the study was to evaluate health-related quality of life (HRQoL) in children and adolescents with IgAN, and compare HRQoL in relation to the disease course, social status and psychological factors, such as expressing anger and perceived personal competence.MATERIAL AND METHODS: The multicentre cross-sectional study included 51 patients ≥ 8 years from 7 paediatric nephrology cen...
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Ma łgorzata Mizerska-Wasiak Dominika Adamczuk Karolina Cicho ń-Kawa Monika Miklaszewska Hanna Szymanik-Grzelak Jacek A Pietrzyk Agnieszka Pukaj ło-Marczyk Danuta Zwoli ńska Agnieszka Rybi-Szumi ńska Anna Wasilewska Beata Bienia ś Przemys ław Sikora Source Type: research

Tumor necrosis factor α, protein gene product 9.5, matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 presence in congenital intra-abdominal adhesions in children under one year of age
CONCLUSIONS: The positive correlation between the immunoreactive structures for TNF-α and PGP 9.5 suggests that nerve in-growth into intraabdominal adhesions might be induced by TNF-α and PGP 9.5 could have a role in maintaining inflammation. The down-regulation of PGP 9.5 suggests that pathogenesis of congenital intraabdominal adhesions may be related to hypoxia induced damage. The imbalance between MMP-2 and TIMP-2 may prove tissue fibrosis as a response to congenital peritoneal adhesions.PMID:33488860 | PMC:PMC7811308 | DOI:10.5114/aoms.2020.101184 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Anna Junga M āra Pilmane Zane Ābola Olafs Volr āts Source Type: research

Urate crystal deposition in hyperuricemic children: a dual energy computed tomography study
CONCLUSIONS: Urate deposition can occur in children with HUA, and these deposits occur more frequently in hyperuricemic children with a history of arthritis symptoms. Also, the urate deposition in the first MTP joint and calcaneus was more prevalent than in other joints. It is important to give more attention to hyperuricemic children.PMID:33488861 | PMC:PMC7811330 | DOI:10.5114/aoms/89835 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Qianqian Ying Jiapei Wang Yunyan Li Nan Sun Yazhen Di Mengjiao Shen Shiwei Fu Source Type: research

Time efficiency of direct anterior hip arthroplasty compared to postero-lateral approach in elderly patients
Arch Med Sci. 2021 Jan 5;17(1):106-112. doi: 10.5114/aoms/86185. eCollection 2021.ABSTRACTINTRODUCTION: Primary arthroplasty of the hip joint is currently one of the most commonly performed procedures in orthopedics. In Poland we are observing significant changes in the age structure. With the prolonged life more and more elderly patients require musculoskeletal surgery to maintain comfortable and painless mobility. Reducing the duration of the procedure reduces the costs of anesthesiology, surgical and instrument teams, as well as the operating room technical team. The aim of the study was to compare the time required to ...
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Pawe ł Skowronek Artur Wojciechowski Krzysztof Wypniewski Marcin Sibi ński Micha ł Polguj Agnieszka Maksymiuk-K łos Pawe ł Piątkiewicz Source Type: research

Comprehensive analysis of key lncRNAs in HCV-positive hepatocellular carcinoma
CONCLUSIONS: We believe that this study can provide novel potential therapeutic and prognostic biomarkers for HCV-positive HCC.PMID:33488867 | PMC:PMC7811325 | DOI:10.5114/aoms.2020.100675 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Jingqi Liu Ligang Chen Jinshui Pan Meiya Chen Jingping Zhou Fei Zhou Peizhong Chen Yang Song Source Type: research

CNTN-1 promotes docetaxel resistance and epithelial-to-mesenchymal transition via the PI3K/Akt signaling pathway in prostate cancer
CONCLUSIONS: The results of the present study suggest that downregulation of CNTN-1 may be an important mechanism to reverse chemoresistance in Dox-resistant PCa progression, thus shedding light on the development of novel anti-tumor therapeutics for the treatment of PCa.PMID:33488868 | PMC:PMC7811318 | DOI:10.5114/aoms.2020.92939 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Binshen Chen Yiming Zhang Chaoming Li Peng Xu Yubo Gao Yawen Xu Source Type: research

Resveratrol is cytotoxic and acts synergistically with NF- κB inhibition in osteosarcoma MG-63 cells
Arch Med Sci. 2020 Nov 13;17(1):166-176. doi: 10.5114/aoms.2020.100777. eCollection 2021.ABSTRACTINTRODUCTION: Osteosarcoma is the most common primary malignancy of the bone. The existing adjuvant chemotherapy regimens, while improving the overall survival, have been limited by the significant systemic toxicity. Substantial clinical and research efforts are being invested to develop novel pharmaceutical agents. Resveratrol (Res) has been suggested to have a chemopreventive effect. However, the mechanism of Res in osteosarcoma remains to be elucidated.MATERIAL AND METHODS: The MG-63 osteosarcoma cell culture model was used ...
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Ning Xu Lili Wang Shiping Fu Bin Jiang Source Type: research

Molecular economy of nature with two thyrotropins from different parts of the pituitary: pars tuberalis thyroid-stimulating hormone and pars distalis thyroid-stimulating hormone
Arch Med Sci. 2021 Jan 5;17(1):189-195. doi: 10.5114/aoms/102476. eCollection 2021.ABSTRACTThyrotropin (TSH) is classically known to be regulated by negative feedback from thyroid hormones and stimulated by thyrotropin-releasing hormone (TRH) from the hypothalamus. At the end of the 1990s, studies showed that thyrotroph cells from the pars tuberalis (PT) did not have TRH receptors and their TSH regulation was independent from TRH stimulation. Instead, PT-thyrotroph cells were shown to have melatonin-1 (MT-1) receptors and melatonin secretion from the pineal gland stimulates TSH-β subunit formation in PT. Electron micr...
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Sibel Ertek Source Type: research

Prognostic value of the < em > PIK3CA < /em > , < em > AKT < /em > , and < em > PTEN < /em > mutations in oral squamous cell carcinoma: literature review
Arch Med Sci. 2020 Nov 13;17(1):207-217. doi: 10.5114/aoms.2020.100780. eCollection 2021.ABSTRACTOver 260,000 (2013) new oral squamous cell carcinoma (OSCC) cases are reported annually worldwide. Despite development in OSCC management, the outcome is still unsatisfactory. Identification of new molecular markers may be of use in prevention, prognosis, and choice of an appropriate therapy. The intracellular molecular signalling pathway of phosphatidyl-inositol-3-kinase is involved in the process of cell growth, differentiation, migration, and survival. The main components of this pathway: PIK3CA (phosphatidylinositol-4,5-bis...
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Anna Starzy ńska Aleksandra Sejda Paulina Adamska Giulia Marvaso Monika Sakowicz-Burkiewicz Łukasz Adamski Barbara A Jereczek-Fossa Source Type: research

Effects of free and nanoparticulate curcumin on chemically induced liver carcinoma in an animal model
CONCLUSIONS: Although the two tested doses of nanoparticulate curcumin were much lower than free curcumin, both doses were effective in preventing HCC development while the low dose of free curcumin was hardly effective. Hence, we conclude that nanoparticles enhance the bioavailability of curcumin.PMID:33488874 | PMC:PMC7811328 | DOI:10.5114/aoms.2020.93739 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Eman Shawky Mohammed Nadia M El-Beih Enas Ali El-Hussieny Eman El-Ahwany Marwa Hassan Mona Zoheiry Source Type: research

< em > PCSK9 < /em > genetic variants and cognitive abilities: a large-scale Mendelian randomization study
CONCLUSIONS: We are unable to rule out meaningful associations of PCSK9 genetic variants with cognition, emphasising the potential need for continued pharmacovigilance for patients currently treated with PCSK9 inhibitors.PMID:33488877 | PMC:PMC7811317 | DOI:10.5114/aoms/127226 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Donald M Lyall Joey Ward Maciej Banach George Davey Smith Jason G Gill Jill P Pell Michael V Holmes Naveed Sattar Source Type: research

Safety, efficacy, length of stay and patient satisfaction with outpatient management of low-risk pulmonary embolism patients - a meta-analysis
CONCLUSIONS: In conclusion, our meta-analysis of 2 randomized controlled trials shows that low-risk pulmonary embolism patients can safely be discharged from the emergency departments in the limited studies available. We need more randomized controlled trials to confirm these findings.PMID:33488878 | PMC:PMC7811300 | DOI:10.5114/aoms/99206 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Aaqib H Malik Wilbert S Aronow Source Type: research

Serum inflammatory markers in the diagnosis and assessment of Crohn's disease activity
CONCLUSIONS: Serum CRP may be useful in the assessment of CD activity and there is a need for introduction of IL-23 for the CD diagnosis.PMID:33488879 | PMC:PMC7811324 | DOI:10.5114/aoms/130842 (Source: Archives of Medical Science)
Source: Archives of Medical Science - January 25, 2021 Category: General Medicine Authors: Krystyna S łowińska-Solnica Dorota Pawlica-Gosiewska Katarzyna Gawlik Danuta Owczarek Dorota Cibor Halina Pocztar Tomasz Mach Bogdan Solnica Source Type: research