Respiratory sinus arrhythmia is reduced after pulmonary vein isolation in patients with paroxysmal atrial fibrillation.
Conclusions: Respiratory sinus arrhythmia is reduced after PVI in patients with paroxysmal AF. Our findings suggest that this is related to a decrease in cardiac vagal tone. Whether and how this affects the clinical outcome including exercise capacity need to be determined. PMID: 32863990 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Circulating brain-derived neurotrophic factor, leptin, neuropeptide Y, and their clinical correlates in cystic fibrosis: a cross-sectional study.
Conclusions: BDNF and leptin were not associated with weight Z-score or FEV1%. Serum NPY concentrations seemed to be lower in CF patients with reduced pulmonary function independently of malnutrition and inflammation. PMID: 32863993 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Novel hematological biomarkers predict survival in renal cell carcinoma patients treated with nephrectomy.
Conclusions: Only dNLR was an independent prognostic factor for CSS and OS. Nevertheless, our study indicates that all examined complete blood count-based biomarkers may be useful tools in managing RCC patients treated with a surgical approach. PMID: 32863995 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Neutrophil-to-mean platelet volume ratio as a new predictor for overall and cancer-specific survival in patients with localized clear cell renal cell carcinoma.
Authors: Życzkowski M, Rajwa P, Burzyński B, Gaździk M, Florczyk I, Slabon-Turska M, Paradysz A Abstract Introduction: The present study investigated the prognostic value of neutrophil-to-mean platelet volume ratio (NMPVR) for overall (OS) and cancer-specific survival (CSS) in patients treated with nephrectomy for localized clear cell renal cell carcinoma (ccRCC). Material and methods: Medical records of 344 consecutive patients who underwent partial or radical nephrectomy for M0 ccRCC were retrospectively analyzed. Based on the median NMPVR, the study population was divided into two groups: the high NMPVR g...
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

A meta-analysis of the prognostic significance of Golgi protein 73 in hepatocellular carcinoma in Chinese patients.
Conclusions: The meta-analysis suggested that overexpression of GP73 may be associated with poor prognosis in HCC and may also have a predictive role for HCC invasion and metastasis. PMID: 32863999 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

MicroRNA-214-5p protects against myocardial ischemia reperfusion injury through targeting the FAS ligand.
Authors: Lu Y, Xi J, Zhang Y, Li C, Chen W, Hu X, Zhang M, Zhang F, Wei H, Li Z, Wang Z Abstract Introduction: MicroRNAs (miRNAs) are considered as crucial modulators in myocardial ischemia and reperfusion (I/R) injury. The present study aimed to investigate the expression and biological functions of miR-214-5p via targeting Fas ligand (FASLG) in I/R injury. Material and methods: Lactate dehydrogenase, casein kinase, malondialdehyde assay, reactive oxygen species (ROS) detection and cell apoptosis analysis measured cell damage and cell apoptosis in H9c2 cells under hypoxia/reperfusion (H/R) treatment. Bioinform...
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Ketamine exhibits anti-gastric cancer activity via induction of apoptosis and attenuation of PI3K/Akt/mTOR.
Conclusions: Our results suggest that ketamine has the ability to inhibit progression of gastric cancer via induction of apoptosis and attenuation of PI3K/Akt/mTOR. PMID: 32864003 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Long non-coding RNA HOTAIR regulates proliferation, migration and invasion of human cervical cancer cells by modulating expression of MAPK1.
Authors: Liu H, Liu J, Zhao G Abstract Introduction: Accumulating evidence suggests that long non-coding RNAs (lncRNAs) are dysregulated in cancer cells and may be responsible for the development and progression of this disease. Herein, the role and therapeutic potential of aberrantly expressed lncRNA HOTAIR were investigated in cervical cancer. Material and methods: The expression profile of the lncRNA HOTAIR was determined by quantitative RT-PCR. CCK-8 and colony formation assays were used for determination of cell viability. DAPI and annexin V/PI assays were used for detection of apoptosis. Wound healing and...
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

MSK1 promotes cell proliferation and metastasis in uveal melanoma by phosphorylating CREB.
Conclusions: MSK1 promotes proliferation and metastasis of uveal melanoma cells by phosphorylated CREB at Ser133 residues. Therefore, MSK1 could be a promising candidate for uveal melanoma therapy and especially has tremendous potential in the treatment of cancers in which the MSK1-CREB pathway is abnormally active. PMID: 32864007 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma.
This study aimed to investigate the prognostic and diagnostic significance of Cavin 2 in lung adenocarcinoma. Material and methods: Cavin 2 expression levels were examined in 150 cases of lung adenocarcinoma and matched adjacent normal lung tissues using RNA extraction and reverse transcription-quantitative polymerase chain reaction (RT-qPCR), Western blotting and immunohistochemistry (IHC) assays. Then, the relationship of Cavin 2 expression with clinicopathological characteristics and patients' survival was further evaluated in lung adenocarcinoma. Results: QPCR and Western blotting analysis indicated that Cavin ...
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

LncRNA PCAT-1 upregulates RAP1A through modulating miR-324-5p and promotes survival in lung cancer.
Conclusions: Our findings demonstrate that on account of the dual function of pro-proliferation and anti-apoptosis, PCAT-1/miR-324-5p/RAP1A may be novel candidates for application in the diagnosis, prognosis and therapy of lung cancer. PMID: 32864009 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Closure of patent foramen ovale for secondary prevention of cryptogenic stroke: current perspectives.
Authors: Makhija RR, Palaniswamy C, Aronow WS PMID: 32864016 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Predictors of long-term survival in patients treated with targeted temperature management after cardiac arrest.
Authors: Bonaventura J, Alan D, Vejvoda J, Pavlíková M, Veselka J PMID: 32864018 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Antibody-drug conjugates: smart weapons against cancer.
Authors: Hayat SMG, Sahebkar A PMID: 32864020 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Particulate matter pollution and the COVID-19 outbreak: results from Italian regions and provinces.
Conclusions: Exposure to PM2.5 and PM10 is associated with COVID-19 cases and deaths, suggesting that particulate matter pollution may play a role in the COVID-19 outbreak and explain the heterogeneous distribution of COVID-19 in Italian regions and provinces. PMID: 32863986 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Modern prevalence of dysbetalipoproteinemia (Fredrickson-Levy-Lees type III hyperlipoproteinemia).
We examined demographic and lipid characteristics stratified by presence of HLP3 and evaluated lipid characteristics in those with HLP3 phenotype discordance and concordance as determined by apoB and originally defined UC criteria 1. Results: In U.S. adults in VLDbL and NHANES, a 1.7-2.0% prevalence is observed for HLP3 with the novel apoB method as compared to 0.2-0.8% prevalence in VLDbL via UC criteria 1-3. Participants who were both apoB and UC criteria HLP3 positive had higher remnant particles as well as more elevated triglyceride/apoB and total cholesterol/apoB ratios (all p
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

A novel mechanism of vitamin D anti-inflammatory/antioxidative potential in type 2 diabetic patients on metformin therapy.
Authors: Cojic M, Kocic R, Klisic A, Cvejanov-Kezunovic L, Kavaric N, Kocic G Abstract Introduction: The performed study focused on determining the effect of vitamin D supplementation on enzymes involved in both inflammation and reactive oxygen species (ROS) production and ROS degradation in patients with type 2 diabetes mellitus (T2DM). Material and methods: The 6-month follow-up, randomized, controlled study included 140 patients with T2DM, ≥ 30 years old, with good metabolic control, treated with metformin and lifestyle advice only. All patients were randomly assigned to two groups (70 each). Patients fro...
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The incidence of recurrent cardiovascular events among acute coronary syndrome patients treated with generic or original clopidogrel in relation to their sociodemographic and clinical characteristics. The Aegean study.
Conclusions: The use of a generic clopidogrel besylate formulation was quite high in both urban and insular areas of Greece and had similar efficacy and safety profile with the original clopidogrel salt, supporting the routine use of this low-cost generic clopidogrel in the management of cardiovascular disease patients. PMID: 32863989 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Cardiovascular risk assessment by electrocardiographic Holter monitoring in patients with chronic hepatitis C.
Conclusions: We confirmed the presence of autonomic disorders with prevalence of sympathetic system activity and prolonged QTc interval in patients with chronic hepatitis C. Those parameters significantly correlated with infection intensity. Our results suggest that HCV infection could be an independent cardiovascular risk factor, not associated with the lipid profile. Further prospective studies are needed. PMID: 32863991 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

A new scoring system for early diagnosis of ventilator-associated pneumonia: LUPPIS.
Conclusions: LUPPIS appears to provide better results in the prediction of VAP compared to CPIS, and the importance of lung ultrasound and PTX-3 is emphasized, which is a distinctive property of LUPPIS. PMID: 32863992 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Three-dimensional organization of the pars fibroreticularis framework of the urethral wall in normal human prostates.
Conclusions: Knowledge of the urethra composition is essential to understand the physiopathological aspects of urinary incontinence. Moreover, our results showed a great amount of connective tissue underlying the prostatic urethra wall. PMID: 32863994 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

A global perspective on the costs of hypertension: a systematic review.
Conclusions: The costs of hypertension calculated per country reached the region of several dozen billion Int$. Other sources usually showed lower costs than those presented in this review. This indicates a growth in costs from year to year and the future increasing burden on society. Globally uniform cost terminology and cost calculation standards need to be developed. That would facilitate making more informed decisions regarding fund allocation in hypertension management schemes. PMID: 32863997 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Prognostic role of tumor-infiltrating lymphocytes in gastric cancer: a meta-analysis and experimental validation.
Conclusions: This meta-analysis clarified that high levels of CD8+, CD3+, and CD4+ T cell infiltration in tumor tissue showed better OS in GC patients, whereas high density of FOXP3+ T cell infiltration may not be recognized as a negative prognostic factor. These results may provide some useful prognostic indicators for clinical application in gastric cancer. PMID: 32863998 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Active surveillance and focal ablation for small renal masses: a better solution for comorbid patients.
Authors: Wośkowiak P, Lewicka K, Bureta A, Salagierski M Abstract The natural history of small renal masses (SRM) is still not well understood and they are frequently incidentally diagnosed in elderly patients. Therefore, there is a need for less invasive options sparing the patient from the side-effects related to conventional surgical treatment. PubMed and Medline database search was performed to look for new findings on active surveillance and focal therapy for SRM. Sixty-one articles published between 2002 and 2018 were selected for the purpose of the review. There is growing evidence confirming the safety of ...
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Over-expression of arginine vasopressin in magnocellular neurosecretory cells of hypothalamus and its potential relationship with development of diabetic nephropathy.
Conclusions: AVP was upregulated in the MNCs of hypothalamus and RVP was upregulated in kidney in streptozotocin-induced DM rats, indicating their potential roles in the development of DN. PMID: 32864002 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Differential expression of angiogenesis-related miRNAs and VEGFA in cirrhosis and hepatocellular carcinoma.
Authors: de Oliveira ARCP, Castanhole-Nunes MMU, Biselli-Chicote PM, Pavarino ÉC, da Silva RCMA, da Silva RF, Goloni-Bertollo EM Abstract Introduction: Liver cirrhosis (LC) is a heterogeneous liver disease, the last stage of liver fibrosis, and the major risk factor for hepatocellular carcinoma (HCC). Our study aimed to evaluate the expression of microRNAs and the endothelial vascular growth factor (VEGFA) gene in LC and HCC. Material and methods: The sample group consisted of 46 tissue samples: 21 of LC, 15 of HCC, and 10 of non-tumoural and non-cirrhotic liver tissue (control group). MiRNAs were chosen...
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

MiR-330-3p functions as a tumor suppressor that regulates glioma cell proliferation and migration by targeting CELF1.
Conclusions: MiR-330-3p inhibited the propagation and migration of glioma cells by repressing CELF1 expression. PMID: 32864006 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Up-regulation of DRAM2 promotes tolerance of bladder transitional cell carcinoma to gemcitabine.
Conclusions: Our data suggested that downregulation of DRAM2 rescued the sensitivity of T24-GEM cells to gemcitabine, providing an appropriate therapeutic target for BTCC treatment. PMID: 32864010 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Evaluation of the mechanism of cordyceps polysaccharide action on rat acute liver failure.
Conclusions: Cordyceps polysaccharide can alleviate the immune response and inflammatory injury in ALF by regulating the balance of pro-inflammatory and anti-inflammatory factors and reducing the apoptosis. PMID: 32864011 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Inverse correlation between levels of glycated haemoglobin and expression levels of SERCA protein in Mexican patients with type 2 diabetes mellitus.
We examined the association between sarco/endoplasmic reticulum calcium ATPase (SERCA) expression and glycated hemoglobin (HbA1c) levels since alterations in this protein expression are associated with the genesis of insulin resistance. HbA1c levels and SERCA protein expression from platelets of Mexican patients diagnosed with type 2 diabetes mellitus (T2DM) were analyzed showing lower values of SERCA expression against the normal values we find in healthy people. Interestingly, as diabetes condition got worse; SERCA protein expression decreased gradually until it was undetectable. The results showed an inverse correlation...
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

CETP inhibition in the REVEAL trial: could we aim higher?
Authors: Sahebkar A, Mikhailidis DP, Banach M PMID: 32864013 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Association between myeloperoxidase rs2333227 polymorphism and susceptibility to coronary heart disease.
Authors: Zhang YQ, Jiang YF, Chen M, Zhang NN, Zhou YF PMID: 32864014 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Long-term outcome of repeated septal reduction therapy after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: insight from the Euro-ASA registry.
Authors: Veselka J, Faber L, Liebregts M, Cooper R, Januska J, Krejci J, Dabrowski M, Hansen PR, Seggewiss H, Horstkotte D, Hansvenclova E, Bundgaard H, Ten Berg J, Jensen MK PMID: 32864015 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Percutaneous left ventricular pseudoaneurysm closure.
Authors: Hnat T, Adlova R, Fiedler J, Veselka J PMID: 32864017 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Allopurinol-induced hypersensitivity syndrome followed by painless thyroiditis in a patient with asymptomatic hyperuricemia.
Authors: Chen X, Cai Y, Ge X PMID: 32864019 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Polysplenia syndrome with a rare variation between the common hepatic artery and the superior mesenteric artery in adults.
Authors: Liu J, Yang K, Wang J PMID: 32864021 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

A review of robust regression in biomedical science research.
Authors: Varin S, Panagiotakos DB PMID: 32864022 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - September 1, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Unexplained anemia in the elderly - a real life analysis of 981 patients.
Authors: Michalak SS, Rupa-Matysek J, Hus I, Gil L Abstract Introduction: We aimed to analyze the prevalence of unexplained anemia (UA) and assess its characteristics, potential causes and impact on survival in an elderly population. Material and methods: Medical files of 981 patients aged ≥ 60 years consulted in one primary medical clinic in Poland in 2013-2014 were retrospectively analyzed. Anemia, defined according to WHO criteria, diagnosed during either hospitalization or outpatient treatment, from the age of 60, was included. Unexplained anemia was diagnosed if, based on available clinical data and lab...
Source: Archives of Medical Science - June 18, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Immune to happiness - inflammatory process indicators and depressive personality traits.
Conclusions: The scales specified for the neurotic triad of the MMPI-2 test correspond substantially with the expression of MnSOD, MPO and metalloproteinases 2 and 9 at the mRNA and protein levels in the group of patients suffering from depression. PMID: 32542087 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - June 18, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Laparoscopic versus open pyeloplasty in children: experience of 226 cases at one centre.
Authors: Polok M, Borselle D, Toczewski K, Apoznański W, Jędrzejuk D, Patkowski D Abstract Introduction: The aim of the study was to compare the efficacy of laparoscopic versus open dismembered pyeloplasty in children. Material and methods: Two hundred and twenty-six Anderson-Hynes pyeloplasties were performed, out of which 131 by open access (OP) and 95 by laparoscopic access (LP). Retrospective analysis of data was performed. The median follow-up was 3 years for LP patients and 6 years for OP patients (p 0.05). Eight patients in the LP group and nine in the OP group required another surgery because of recur...
Source: Archives of Medical Science - June 18, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

MiR-345-5p inhibits tumorigenesis of papillary thyroid carcinoma by targeting SETD7.
Conclusions: MiR-345-5p exhibited suppressive effects on PTC via targeting SETD7. PMID: 32542092 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - June 18, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Semen affects the biological behavior of HeLa cells by altering ERK signaling.
Authors: Guo ZQ, Zhang DD, Pang L, Wang YT, Cao P, Zhang SL Abstract Introduction: The aim of the study was to investigate the effects of human semen on the proliferation, survival, migration and invasion of HeLa cervical cancer cells by analyzing the extracellular regulated protein kinase (ERK) pathway. Material and methods: HeLa cells were stimulated with different concentrations of human semen. MTT assay was used to analyze the effects on cell proliferation. Apoptosis in the different experimental groups was quantified by Annexin V-FITC/PI staining. The effect of seminal plasma on in vitro invasiveness of ce...
Source: Archives of Medical Science - June 18, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Sulodexide up-regulates glutathione S-transferase P1 by enhancing Nrf2 expression and translocation in human umbilical vein endothelial cells injured by oxygen glucose deprivation.
Authors: Gabryel B, Bontor K, Jarząbek K, Plato M, Pudełko A, Machnik G, Urbanek T Abstract Introduction: Sulodexide (SDX) is used for the treatment of many vascular disorders due to its anticoagulant, anti-inflammatory and anti-atherosclerotic properties. However, the detailed molecular mechanism of its endothelioprotective action is still not completely understood. There is increasing evidence suggesting that antioxidant enzymes play an important role in anti-ischemic properties of SDX. We postulate that up-regulation of glutathione-S-transferase P1 (GSTP1) mediated by the transcription factor Nrf2 could be ass...
Source: Archives of Medical Science - June 18, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Lycium barbarum polysaccharides exert an antioxidative effect on rat chondrocytes by activating the nuclear factor (erythroid-derived 2)-like 2 signaling pathway.
Authors: Chen Y, Bi Q, Zhu Z, Zhang S, Xu J, Dou X, Mao W Abstract Introduction: Oxidative stress is the main cause of osteoarthritis (OA). Lycium barbarum polysaccharides (LBP) have antioxidant properties. Thus, the potential effect of LBP on H2O2-stimulated chondrocytes was examined. Material and methods: The cell viability was detected by CCK-8. The reactive oxygen species (ROS) production and apoptosis rates were determined by flow cytometric analysis. The DNA damage was detected by comet assay. Real-time polymerase chain reaction (qPCR) and Western blot assays were performed to examine the expression of hi...
Source: Archives of Medical Science - June 18, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Ankyrins in human health and disease - an update of recent experimental findings.
Authors: Chagula DB, Rechciński T, Rudnicka K, Chmiela M Abstract Ankyrins are adaptor molecules that in eukaryotic cells form complexes with ion channel proteins, cell adhesion and signalling molecules and components of the cytoskeleton. They play a pivotal role as scaffolding proteins, in the structural anchoring to the muscle membrane, in muscle development, neurogenesis and synapse formation. Dysfunction of ankyrins is implicated in numerous diseases such as hereditary spherocytosis, neurodegeneration of Purkinje cells, cardiac arrhythmia, Brugada syndrome, bipolar disorders and schizophrenia, congenital myopa...
Source: Archives of Medical Science - June 17, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Effects of antidepressants on QT interval in people with mental disorders.
Conclusions: Evidence regarding the risk of QT prolongation in children is sparse. PMID: 32542073 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - June 17, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Serum vitamin D deficiency and risk of gestational diabetes mellitus: a meta-analysis.
Conclusions: Vitamin D is closely associated with the onset of GDM. PMID: 32542074 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - June 17, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Internal drainage versus external drainage in palliation of malignant biliary obstruction: a meta-analysis and systematic review.
Authors: Tian X, Zhang Z, Li W Abstract Introduction: Preoperative biliary drainage has been widely used to treat patients with malignant biliary obstruction. However, it is still unclear which method is more effective: internal drainage or external drainage. Thus, we carried out a meta-analysis to compare the safety and efficacy of the two drainage methods in treatment of malignant biliary obstruction in terms of preoperative and postoperative complications. Material and methods: We conducted a literature search of Medline, EMBASE, PubMed, Ovid journals and the Cochrane Library, and compared internal drainage ...
Source: Archives of Medical Science - June 17, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Multicentre early experience with totally subcutaneous cardioverter-defibrillators in Poland.
Conclusions: S-ICD implantation procedure has been successfully and safely introduced in Polish clinical routine. Nevertheless, despite clear indications in recent ESC guidelines, this therapy is not directly reimbursed in Poland and needs individual application for refund. PMID: 32542076 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - June 17, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Associations of changes in patient characteristics and management with decrease in mortality rates of men and women with ST-elevation myocardial infarction - a propensity score-matched analysis.
Conclusions: The progress in the treatment strategies has helped to achieve better survival rates in STEMI patients. However, the ongoing changes in clinical characteristics of patients also played an important role, especially in women. Clinicians should focus on modifiable risk factors and post-discharge management to possibly prolong the positive aspects of in-hospital efforts. PMID: 32542077 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - June 17, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research