Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction.
Authors: Baars T, Sowa JP, Neumann U, Hendricks S, Jinawy M, Kälsch J, Gerken G, Rassaf T, Heider D, Canbay A Abstract Introduction: Liver parameters are associated with cardiovascular disease risk and severity of stenosis. It is unclear whether liver parameters could predict the long-term outcome of patients after acute myocardial infarction (AMI). We performed an unbiased analysis of the predictive value of serum parameters for long-term prognosis after AMI. Material and methods: In a retrospective, observational, single-center, cohort study, 569 patients after AMI were enrolled and followed up until 6 y...
Source: Archives of Medical Science - February 15, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Comparison of two VHIT software programs in diagnostics of semicircular canals.
Conclusions: The examination using VHIT ULMER II appears to be a more sensitive diagnostic method than VHIT ULMER I. Improved software with automated functions such as camera adjustments, examination surface arrangement, of VHIT ULMER II, enables technician to shorten the time of examination, simultaneously providing a range of new information about the condition of oculo-vestibular system. PMID: 32051715 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Risk of tuberculosis in low birth weight children from East Romania.
Authors: Banu EA, Nechita A, Elkan-Cojocaru EM, Baciu G, Manole A, Chelaru L Abstract Introduction: In the context of the global tuberculosis (TB) burden, children represent 10% of all cases, with high incidence rates still reported by many regions worldwide. The study aim was to determine whether there is a correlation between TB clinical diagnosis and low birth weight in children at various ages. Material and methods: The study was conducted between 2010 and 2014, on a group of 1783 pediatric patients and a subgroup of 137 pediatric patients with low birth weight (LBW). Data were collected from patients' reco...
Source: Archives of Medical Science - February 15, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Protective effects of benfotiamine on irisin activity in methotrexate-induced liver injury in rats.
Authors: Erdogan MA, Yalcin A Abstract Introduction: Methotrexate (MTX) causes hepatotoxicity by producing oxidative stress. Benfotiamine and irisin have protective effects against oxidative stress. The aim of this study was to investigate the changes in irisin activity in the liver as a result of toxicity produced by MTX and the protective role of benfotiamine in the hepatotoxicity. Material and methods: Rats were divided into 4 groups as follows: control, benfotiamine (50 mg/kg, oral gavage (o.g.), for 14 days), MTX (MTX 20 mg/kg intraperitoneally (i.p.) on day 1), MTX + benfotiamine (MTX 20 mg/kg (i.p.) on d...
Source: Archives of Medical Science - February 15, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Hypoxis hemerocallidea alters metabolic parameters and hepatic histomorphology in streptozotocin-nicotinamide-induced diabetic male rats under antiretroviral therapy.
This study aimed at investigating the possible protective effect of Hypoxis hemerocallidea (HH) against metabolic and hepatic histomorphology of diabetic rats under HAART. Material and methods: Sixty-two adult male Sprague-Dawley rats were divided into a normoglycemic group A (n = 6) and 7 diabetic (110 mg/kg nicotinamide + 45 mg/kg streptozotocin) groups (B-H) (n = 8) and treated according to protocols. Concomitant treatment with adjuvant HH and HAART resulted in the least %body weight gain as the liver weight decreased in all treated animals. Results: Significant changes in serum lipids were aggravated by treatme...
Source: Archives of Medical Science - February 15, 2020 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The effect of statins on psoriasis severity: a meta-analysis of randomized clinical trials.
Authors: Socha M, Pietrzak A, Grywalska E, Pietrzak D, Matosiuk D, Kiciński P, Rolinski J Abstract Introduction: Statins may reduce the severity of psoriasis, but the available evidence is unclear. We conducted a meta-analysis of randomized controlled studies (RCTs) that investigated the effect of statins on psoriasis severity assessed with the Psoriasis Area and Severity Index (PASI). Material and methods: Two investigators searched independently the following databases: Medline, EMBASE, Cochrane Central Register of Controlled Trials and ClinicalTrials.gov from inception to February 2019. Additionally, refere...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Pregnancy-associated plasma protein A as a predictor of all-cause mortality and cardiovascular events in patients with chronic kidney disease: a meta-analysis of prospective studies.
Conclusions: Our study suggests that elevated serum PAPP-A is associated with the risk of all-cause mortality in patients with CKD. PMID: 32051700 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

The association between fibroblast growth factor receptor 1 gene amplification and lung cancer: a meta-analysis.
Conclusions: These results suggest that FGFR1 amplification occurs more frequently in SCC and in Asians. FGFR1 amplification may be a potential new therapeutic target for specific patients and lung cancer subtypes. PMID: 32051701 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Genetic causes of hypopituitarism.
Authors: Parkin K, Kapoor R, Bhat R, Greenough A Abstract Hypopituitarism in neonates is rare, but has life-threatening complications if untreated. This review describes the features of hypopituitarism and the evidence for which infants in whom a genetic cause should be suspected. Importantly, neonates are often asymptomatic or present with non-specific symptoms. Hypopituitarism can be due to abnormal gland development as a result of genetic defects, which result from mutations in gene coding for transcription factors which regulate pituitary development. The mutations can be divided into those causing isolated hyp...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Changes in the incidence and prevalence of type 1 and type 2 diabetes among 2 million children and adolescents in Hungary between 2001 and 2016 - a nationwide population-based study.
Authors: Barkai L, Kiss Z, Rokszin G, Abonyi-Tóth Z, Jermendy G, Wittmann I, Kempler P Abstract Introduction: The aim of the present study was to assess changes in the incidence and prevalence of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) in children and adolescents in Hungary during the period 2001 to 2016 in order to provide nationwide population-based epidemiology data on diabetes in youths aged 0-18 years. Material and methods: This was a retrospective cohort study of Hungarian children and adolescents aged 18 years or younger. Pharmacologically treated diabetes cases were obtained through a p...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Endocan and a novel score for dyslipidemia, oxidative stress and inflammation (DOI score) are independently correlated with glycated hemoglobin (HbA1c) in patients with prediabetes and type 2 diabetes.
Authors: Klisic A, Kavaric N, Stanisic V, Vujcic S, Spasojevic-Kalimanovska V, Ninic A, Kotur-Stevuljevic J Abstract Introduction: We aimed to examine serum endocan level and the summary involvement of dyslipidemia, oxidative stress (OS) and inflammation by calculation of its comprehensive score (i.e. Dyslipidemia-Oxy-Inflammation (DOI) score) in relation to glucoregulation in subjects with prediabetes and overt type 2 diabetes (T2D). Material and methods: A total of 59 patients with prediabetes and 102 patients with T2D were compared with 117 diabetes-free controls. Glycated hemoglobin (HbA1c), inflammation, O...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis.
In this study, we analyzed the potential effect of collateral circulation on prognosis prediction of triiodothyronine for large artery atherosclerosis cerebral infarction (LAA-CI) patients. Material and methods: Clinical data of CI patients between 2012 and 2014 were collected. Imaging inspection was used for determining TOAST classification and evaluating collateral circulation. One-year follow-up was conducted for mRS score by telephone. Results: T3 level in the NTIS group (p = 0.001) was significantly decreased while TSH level (p
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Three-dimensional ultrasonographic evaluation of carotid artery plaque surface irregularity.
Conclusions: The present study shows that 3D US examination is a valuable non-invasive method for investigation of surface irregularity of carotid artery plaques. PMID: 32051706 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Heightened risk of cardiac events following percutaneous coronary intervention for cocaine-associated myocardial infarction.
Conclusions: This retrospective study suggests that PCI performed in cocaine-associated myocardial infarction comes with a high 30-day and one-year risk. Further prospective studies are needed to better define this risk and to lend insight into better management strategies. PMID: 32051707 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Is pentraxin 3 level an effective biomarker in disease activity in patients with rheumatoid arthritis?
Authors: Balbaloglu O, Ozcan SS Abstract Introduction: The aim of the current study was to identify whether serum pentraxin 3 (PTX3) level could be a marker of increased inflammation in rheumatoid arthritis (RA) patients. Material and methods: The study included 41 patients diagnosed with RA according to the American College of Rheumatology (ACR) 1990 diagnostic criteria. We compared the serum PTX3 levels between RA patients and a healthy control group, the relationship between PTX3 level and disease activity was also examined. Results: A statistically significant difference was determined between the RA pa...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

HPV genotyping and p16/Ki-67 test significantly improve detection rate of high-grade cervical squamous intraepithelial lesion.
We reported a strong correlation between positive Pap test and hrHPV (p
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

The effect of antioxidant status on overall survival in renal cell carcinoma.
Authors: Pavlović I, Pejić S, Radojević-Škodrić S, Todorović A, Stojiljković V, Gavrilović L, Popović N, Basta-Jovanović G, Džamić Z, Pajović SB Abstract Introduction: The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients. Materi...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Comparison of risk factors between colon cancer and rectum cancer in a single medical center hospital, Taiwan.
Conclusions: The long-term survival from CRC, colon cancer and rectum cancer remains promising, as 68.66%, 69.11% and 67.90% of patients are alive 5 years after being diagnosed, respectively. Perineural invasion was found to be an important factor related to the survival of patients who have CRC. Thus, early detection of CRC may help improve survival. PMID: 32051712 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

The MDR1/ABCB1 gene rs 1045642 polymorphism in colorectal cancer.
Conclusions: The MDR1/ABCB1 gene polymorphism rs 1045642 may be involved in the pathogenesis of CRC and this relationship may be sex-specific for males. However, further population studies are necessary to assess this relationship. PMID: 32051713 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Intra-day variations of blood reelin levels in healthy individuals.
Conclusions: Our findings point to short-term fluctuations in blood RELN levels being part of physiological RELN homeostasis. This is of special interest with regard to a potential clinical use of RELN as a biomarker. PMID: 32051714 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Two-dimensional system based on organic and functional impairment with aging for precisely assessing risk factors in chronic disease.
Authors: Cengfang W, Hanboya G, Hui L Abstract Introduction: The aim of the study was to establish a two-dimensional system based on organic and functional biological age (BA) using a biomarker of organic and functional impairment with aging for precisely assessing roles of natural aging and other risk factors in chronic disease. Material and methods: The index of organic mild impairment, which is similar to the frailty index, was determined with imaging parameters as organic BA. The functional BA was calculated with the following formula: Functional BA = [systolic - diastolic BP (mm Hg)] × waist circumfe...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Association of burnout syndrome and global self-esteem among Polish nurses.
Conclusions: Developing personal resources and deriving benefits from them may be important in the prevention of burnout syndrome. This study indicated the need to carry out preventive measures in the workplace to protect nurses from burnout. PMID: 32051717 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Breast cancer mortality trends in Europe among women in perimenopausal and postmenopausal age (45+).
Conclusions: Due to the availability of better treatment options, as well as presence of effective tools for detecting BC at the early stages of progression, BC mortality is falling in most analyzed European countries. To maintain this situation and to stop BC mortality increase in the analyzed age group in Bulgaria, Croatia, Poland, Romania and Slovakia, immediate actions for improvement of BC management in the European health care systems should be considered. PMID: 32051718 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Hepatitis B virus screening in patients with non-Hodgkin lymphoma in clinical practice in Poland - a report of the Polish Lymphoma Research Group.
Conclusions: In Polish lymphoma patients the incidence of positive HBsAg and/or anti-HBc results is consistent with the prevalence in the United States or Australia. The adherence to appropriate HBV screening guidelines in Polish centers is not sufficient. We should intensify educational strategies in the global oncohematologic medical community. PMID: 32051719 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

MiR-135b-5p promotes viability, proliferation, migration and invasion of gastric cancer cells by targeting Kr üppel-like factor 4 (KLF4).
Conclusions: The inhibitory effects of ectopic KLF4 could be attenuated by co-transfection of miR-135b-5p. Collective data suggested that miR-135b-5p has a tumor-promoting role in GC cells via downregulating KLF4. Hence, inhibition of miR-135b-5p could be valuable for treatment of gastric cancer. PMID: 32051721 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Aberrant expression of long non-coding RNAs (lncRNAs) is involved in brain glioma development.
We examined lncRNA profiles from three glioma specimens using lncRNA expression profiling microarrays. Quantitative real-time RT-PCR was used to analyze the differential expression of raw intensities of lncRNA expression in glioma and peritumoral tissues. Results: We found 4858 lncRNAs to be differentially expressed between tumor tissue and peritumoral tissue. Of these, 2845 lncRNAs were up-regulated (fold change> 3.0) and 2013 were down-regulated (fold change 3.0) and 1804 that were down-regulated (fold change
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Effects of immunisation against PCSK9 in mice bearing melanoma.
Conclusions: The nanoliposomal PCSK9 vaccine did not adversely affect the growth of melanoma tumour nor the survival of tumour-bearing mice. PMID: 32051723 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

The effects of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus region of the rat hippocampus in vivo.
Authors: Yang L, Wu, Wang B, Bu X, Zhu J, Tang J Abstract Introduction: The aim of our study is to investigate the effect of hyperbilirubinaemia on synaptic plasticity in the dentate gyrus (DG) region of the rat hippocampus. Material and methods: Seven-day-old healthy Sprague Dawley (SD) rats were randomly divided into a control group and an experiment group (n = 20 in each group). The input/output (I/O) functions, paired-pulse reactions (PPR), excitatory postsynaptic potential (EPSP), and population spike (PS) amplitude were measured in the DG area of both groups of rats in response to stimulation applied to t...
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Some clarifications of terminology may facilitate sarcopenia assessment.
Authors: Lewandowicz A, Sławiński P, Kądalska E, Targowski T PMID: 32051727 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Clinical characteristics and outcomes of patients with overlapping Miller Fisher syndrome and myasthenia gravis.
Authors: Yuan JL, Xing Y, Hu WL PMID: 32051728 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - February 15, 2020 Category: General Medicine Tags: Arch Med Sci Source Type: research

Is type 2 diabetes mellitus a coronary heart disease equivalent or not? Do not just enjoy the debate and forget the patient!
Authors: Katsiki N, Banach M, Mikhailidis DP Abstract In the last several years there has been a large debate whether patients with type 2 diabetes (T2DM) should be treated as those with high or very high cardiovascular risk, and whether T2DM should be considered as equivalent to coronary heart disease (CHD). It all started in the 2001 in National Cholesterol Education Program - Adult Treatment Panel III recommendations, and the knowledge has changed on this issue at least several times. But the main problem is that due to these inconsistencies and different approaches to the cardiovascular risk of T2DM patients, w...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Pulse wave velocity as a measure of arterial stiffness in patients with familial hypercholesterolemia: a systematic review and meta-analysis.
Conclusions: This meta-analysis suggests that FH patients do not have significantly altered PWV when compared with normocholesterolemic individuals. However, a subanalysis of studies in which IMT was measured indicated that IMT is increased in FH patients compared with controls. PMID: 31749863 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Association of lipoprotein(a) and major adverse cardiovascular events in patients with percutaneous coronary intervention.
Authors: Chen Z, Jiang C, Qu H, Liang S, Yang J, Wu H, He C, Wang X Abstract Introduction: The aim of the current study was to evaluate the association between lipoprotein(a) [Lp(a)] and major adverse cardiovascular events (MACEs) in patients with percutaneous coronary intervention (PCI) treatment. Material and methods: This was a retrospective study. The demographics, prior medical histories, comorbidities and laboratory parameters were collected from the electronic health record. All participants were followed up for 1 year after the indexed PCI. Studied end points were a composite of MACEs including all-caus...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Effects of blood pressure goals on cardiovascular outcomes in hypertensive patients.
Authors: Du Z, Bian W, Wu S, Gao B, Sun Y, Kang Z, Zhang X Abstract Introduction: The aim of the study was to evaluate the effects of blood pressure (BP) goals on cardiovascular outcomes in hypertensive patients. Material and methods: Primary hypertensive patients were retrospectively enrolled from outpatient clinics. The demographics, comorbidities, laboratory parameters and glomerular filtration rate (GFR) were collected. All participants were followed for 1 year. Cardiovascular outcomes included composite of all-cause mortality, non-fatal myocardial infarction, and non-fatal ischemic stroke/transient ischemi...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Increased carotid plaque burden in patients with family medical history of premature cardiovascular events in the absence of classical risk factors.
The objective of this study was to investigate whether FHx is associated with a higher atherosclerotic burden, measured as carotid total plaque area (TPA) in a population having no traditional RF. Material and methods: The study included 4,351 primary care patients in Argentina. After excluding a personal history of cardiovascular disease (CVD) and TRF: hypertension, diabetes mellitus, hypercholesterolemia, smoking history, and body mass index (BMI)> 25 kg/cm2, 34 patients with FHx were identified. Compared to 56 matched controls TPA was 86% higher in FHx patients (p
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Prognostic role of traditional cardiovascular risk factors in patients with idiopathic pulmonary arterial hypertension.
Conclusions: Patients with IPAH are characterized by an altered profile of lipid and glucose metabolism. Lowered levels of LDL-C and HDL-C and increased TG/HDL-C ratio correlate with disease severity and together with elevated plasma glucose level predict poor survival in IPAH. PMID: 31749867 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Abnormal serum fatty acid profile in psoriatic arthritis.
Authors: Mysliwiec H, Harasim-Symbor E, Baran A, Szterling-Jaworowska M, Milewska AJ, Chabowski A, Flisiak I Abstract Introduction: Psoriatic arthritis (PsA) is a chronic inflammatory disease associated with higher risk of cardiovascular events and metabolic syndrome than psoriasis without arthritis. Fatty acids (FA) play an important role as signaling molecules in inflammatory and metabolic pathways. The aim of the study was to evaluate serum FA concentration in patients with PsA and to investigate the correlations of FA with the clinical and biochemical markers. Material and methods: We measured 14 FA serum c...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Modulator role of infliximab and methotrexate through the transient receptor potential melastatin 2 (TRPM2) channel in neutrophils of patients with rheumatoid arthritis: a pilot study.
Conclusions: Our results suggest that INF and MTX are useful antagonists in apoptosis and mitochondrial oxidative stress in the neutrophils of RA patients. INF and MTX decreased the Ca2+ concentration through inhibition of the TRPM2 channel in the neutrophils of RA patients. It may be a new pathway in the mechanisms of anti-rheumatic drugs. PMID: 31749869 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Evaluation of folate concentration in amniotic fluid and maternal and umbilical cord blood during labor.
This study was conducted on 175 pregnant Polish women (white/Caucasian) aged between 17 and 42 years. Only pregnancies without birth defects were included in this study. Amniotic fluid, maternal serum, and umbilical cord blood samples were collected during vaginal delivery or cesarean section. Folate concentration was determined using a microbiological assay. Results: Strong correlations were observed between the concentrations of folate in amniotic fluid and maternal serum (rho = 0.67, p
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Clinicopathological factors associated with novel prognostic markers for patients with triple negative breast cancer.
Authors: Badowska-Kozakiewicz AM, Budzik MP, Liszcz A, Sobieraj MT, Czerw AI, Sobol M, Patera J, Deptała A Abstract Introduction: Triple negative breast cancer (TNBC) is characterized by a worse prognosis than other breast cancer subtypes. TNBC is defined by lack of expression of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2. The aim of this analysis was to evaluate the relationship between immunohistochemical expression of novel prognostic markers (erythropoietin (EPO) and erythropoietin receptor (EPO-R)) and clinicopathological features of TNBC and non-TNBC patients. M...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Is percutaneous computed tomography-guided biopsy sufficient to establish indolent lymphoma transformation?
Conclusions: Percutaneous CT guided biopsy performed in patients with a history of indolent lymphoma had high accuracy in establishing the correct diagnosis regarding transformation, relapse, duplicate malignancy or a benign process. Simultaneously, the complication rate was low. PMID: 31749872 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

MicroRNA-122a as a non-invasive biomarker for HCV genotype 4-related hepatocellular carcinoma in Egyptian patients.
This study aims to develop a non-invasive diagnostic tool based on measuring the serum levels of different miRNAs in order to detect HCV-induced HCC at the early stages of the disease. Material and methods: Five main miRNAs (miRNA-122a, miRNA-125a, miRNA-139, miRNA-145, and miRNA-199a) were selected according to the literature that demonstrated their unique expression pattern during HCC development. Serum samples were collected from 42 cases of chronic hepatitis C (CHC) without cirrhosis, 45 cases of CHC with cirrhosis (LC), 38 cases of HCC with HCV, and 40 healthy individuals serving as a control. The five miRNAs were...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Hepatopathy of unknown etiology - is liver biopsy a good tool in differential diagnosis?
Conclusions: Liver biopsy - despite the increasing access to new, non-invasive methods - remains a useful method in the differential diagnosis of liver diseases. PMID: 31749874 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Evaluation of the effectiveness of iodine prophylaxis in Poland based on over 20 years of observations of iodine supply in school-aged children in the central region of the country.
Conclusions: Iodine prophylaxis has proved effective in eliminating iodine deficiency. In recent years, the diversification of iodine sources, despite the reduction of salt consumption, has led to an increase in median UIC to values close to the upper limit of UIC, accepted as normal. Further increase in iodine supply may be unfavourable for health; therefore constant monitoring of iodine prophylaxis is required. PMID: 31749875 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Prevalence of Helicobacter pylori in Turkish children with celiac disease and its effect on clinical, histopathological, and laboratory parameters.
Conclusions: The prevalence of HP was not increased in cases of CD. The CD was diagnosed later in HP (+) cases, distension and diarrhea complaints were more frequent, and folate deficiency was significant. PMID: 31749876 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Duration of empirical therapy in neonatal bacterial meningitis with third generation cephalosporin: a multicenter retrospective study.
Conclusions: Third generation cephalosporin therapy does not have a different prognosis for negative CSF culture of neonatal bacterial meningitis in term infants in this study. PMID: 31749877 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

miR-21 regulates vascular smooth muscle cell function in arteriosclerosis obliterans of lower extremities through AKT and ERK1/2 pathways.
Conclusions: We demonstrated that the expression of miR-21 in HASMCs could find potential application in cardiac therapy. Inhibition of the activity of AKT or ERK could attenuate miR-21-induced cell proliferation and migration as well as altering morphology of HASMCs. The present study aimed to indicate the potential roles of miR-21 in ASO processes, and the results provided a novel therapeutic approach for treating ASO and new targets for preventing ASO in earlier stages. PMID: 31749878 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Effects of vascular endothelial growth factor and epidermal growth factor on biological properties of gastric cancer cells.
This study investigates the effects of vascular endothelial growth factor (VEGF) and epidermal growth factor (EGF) on the biological properties of gastric cancer cells. Material and methods: mRNA expression of VEGF and EGF in gastric cancer tissues from 80 patients suffering from serosa-infiltrated gastric cancer (T3) was examined. The differences of proliferation, movement, adhesion and invasion among 4 gastric cancer cell lines were analysed. The mRNA expression of EGF, EGFR, VEGF and VEGFR in the gastric cancer cell lines was examined before and after adding endostatin (Endostar) or cetuximab (Erbitux) to observe ch...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

Effects of paclitaxel and cisplatin on in vitro ovarian follicle development.
This study aimed to investigate the concentrations at which cisplatin and paclitaxel, alone or combined, affect the in vitro development of ovarian follicles. Their differential effects on the oocytes and surrounding granulosa cells was also evaluated. Material and methods: Ovarian follicles were cultured in vitro using gonadotropins and treated with 10-8-10-10 M of cisplatin, paclitaxel, or both. At day 13, granulosa cells and oocytes were retrieved and used for imaging and functional analyses. Results: Follicular survival and growth was significantly suppressed in all treatment groups at 10-9 M or higher concentr...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research

MicroRNA-331-3p inhibits proliferation and metastasis of ovarian cancer by targeting RCC2.
Authors: Buranjiang G, Kuerban R, Abuduw.e A, Li X, Kuerban G Abstract Introduction: Epithelial ovarian carcinoma (EOC) is one of the most lethal gynecologic malignancies, with a poor 5-year survival rate. Numerous studies have shown that microRNAs participate in the malignant behavior of ovarian cancer cells by directly targeting multiple oncogenes or tumor suppressor genes. Material and methods: Reverse transcription-PCR was used to determine the level of miR-331-3p in EOC. Cells proliferation was measured with the Cell Counting Kit-8. Cell mobility were measured by wound-healing assay. Cell migration and inv...
Source: Archives of Medical Science - November 23, 2019 Category: General Medicine Tags: Arch Med Sci Source Type: research