Skin perfusion pressure for the prediction of wound healing in critical limb ischemia: a meta-analysis.
Conclusions: Skin perfusion pressure can accurately predict wound healing in patients with critical limb ischemia. PMID: 29765431 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Utility and safety of three-dimensional contrast low-dose dobutamine echocardiography in the evaluation of myocardial viability early after an acute myocardial infarction.
Conclusions: 3DCLDDE and LDDE are equally safe and useful in patients after STEMI. PMID: 29765432 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Left ventricular structural and functional changes evaluated by echocardiography and two-dimensional strain in patients with sickle cell disease.
Authors: Bedirian R, Soares AR, Maioli MC, de Medeiros JFF, Lopes AJ, Castier MB Abstract Introduction: Patients with sickle cell disease have increased left ventricular size, which is not usually accompanied by changes in systolic function indexes. We assessed echocardiographic abnormalities present in patients with sickle cell anemia (SCA) and compared echocardiographic parameters to other sickle cell diseases (OSCD). Material and methods: A blind cross-sectional study with 60 patients with SCA and 16 patients with OSCD who underwent transthoracic echocardiography was performed. Results: Echocardiographic...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Risk factors and prognostic role of an electrical storm in patients after myocardial infarction with an implanted ICD for secondary prevention.
Authors: Kwaśniewski W, Filipecki A, Orszulak M, Orszulak W, Urbańczyk D, Roczniok R, Trusz-Gluza M, Mizia-Stec K Abstract Introduction: The aim of our study was to determine the risk factors for electrical storm (ES) and to assess the impact of ES on the long-term prognosis in patients after myocardial infarction (MI) with an implantable cardioverter-defibrillator (ICD) for secondary prevention of sudden cardiac death (SCD). Material and methods: We retrospectively analyzed 416 patients with coronary artery disease after MI who had an implanted ICD for secondary prevention of SCD. Fifty (12%) patients had on...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Mortality of adult intensive care units in Turkey using the APACHE II and SOFA systems (outcome assessment in Turkish intensive care units).
Conclusions: There was a wide difference in outcome for patients admitted to different ICUs and severity of illness using risk adjustment methods. The high mortality rate in patients could be related to comorbid diseases, high mechanical ventilation rates and older ages. PMID: 29765435 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Anti-thyroid antibodies, parietal cell antibodies and tissue transglutaminase antibodies in patients with autoimmune thyroid disease.
Conclusions: Considering the frequency of PC-Ab and tTG-Ab positivity in ATD, checking for the presence of these two entities should be an integral part of the workup of this disease. PMID: 29765436 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Evaluation of ovarian reserve in women with overt or subclinical hypothyroidism.
Conclusions: Although AMH values were not significantly different among groups, AMH values were lower in OH and SCH patients, indicating a possible need for close monitoring of these patients. PMID: 29765437 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Decline in ovarian reserve may be an undiagnosed reason for unexplained infertility: a cohort study.
Conclusions: Although anti-Müllerian hormone values and antral follicle count were higher than the low thresholds, a statistically significant decline of ovarian reserve in the unexplained infertility group was found in the present study. This might be an undiagnosed reason for unexplained infertility. PMID: 29765438 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Radiographic features of anatomic relationship between impacted third molar and inferior alveolar canal on coronal CBCT images: risk factors for nerve injury after tooth extraction.
Authors: Wang D, Lin T, Wang Y, Sun C, Yang L, Jiang H, Cheng J Abstract Introduction: The present study was aimed to identify the radiographic signs between impacted third molar root and inferior alveolar canal (IAC) on cone-beam CT (CBCT) images as risk factors and prognostic predictors associated with inferior alveolar nerve (IAN) damage following tooth removal. Material and methods: A retrospective clinical study was performed involving 136 patients with 257 impacted lower third molars from January 2013 to December 2014. The neurosensory function of the lower lip and chin was subjectively evaluated and asse...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Prevalence of bacteria and fungi in samples of cornea preservation fluid.
Conclusions: We postulate that perioperative antibiotic prophylaxis in cornea transplant recipients is important in preventing bacterial infections derived from the donor cornea. We believe that the addition of an antifungal agent to commercially available cornea preservation fluids should also be considered. PMID: 29765440 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Suspected unexpected and other adverse reactions to antiretroviral drugs used as post-exposure prophylaxis of HIV infection - five-year experience from clinical practice.
Conclusions: In our observations ADRs in reaction to nPEP were frequent yet usually mild events, mostly occurring in the first 2 weeks and rarely causing discontinuation. The only significant factor increasing the risk of ADR was age. SUSARs were rare, transient and clinically insignificant. PMID: 29765441 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Hepatitis C coinfection adversely affects the life expectancy of people living with HIV in northwestern Poland.
This study aimed to analyze the HCV-associated influence on the life expectancy among HIV/HCV coinfected patients from northwestern Poland. Material and methods: Longitudinal data of 701 (368 HIV monoinfected and 368 HIV/HCV coinfected) patients were investigated to assess the life expectancy and survival after HIV diagnosis. Kaplan-Meier and Cox analyses were used to assess the mortality risk in both unadjusted and multivariate models. Effect plots indicate the adjusted hazard ratio for HCV-associated survival. Results: Overall mortality was significantly higher among HCV coinfected (22.52%) compared to HIV monoin...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Management of cardiac hemochromatosis.
Authors: Aronow WS Abstract Iron-overload syndromes may be hereditary or acquired. Patients may be asymptomatic early in the disease. Once heart failure develops, there is rapid deterioration. Cardiac hemochromatosis is characterized by a dilated cardiomyopathy with dilated ventricles, reduced ejection fraction, and reduced fractional shortening. Deposition of iron may occur in the entire cardiac conduction system, especially the atrioventricular node. Cardiac hemochromatosis should be considered in any patient with unexplained heart failure. Screening for systemic iron overload with serum ferritin and transferin s...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Sequentiality of treatment in the rheumatoid arthritis drug programme in the years 2009-2014.
Authors: Tłustochowicz M, Śliwczyński AM, Brzozowska M, Teter Z, Marczak M Abstract Approximately 1% of the population suffers from rheumatoid arthritis (RA) worldwide (0.45% in Poland). The therapy consists of the use of disease-modifying antirheumatic drugs (DMARDs). Biologics are used in the form of the drug programme. Analysis of the NHF database demonstrated the sequence of conversion between drugs and time spent in a single treatment. In 2009, the patients would start the following treatments: adalimumab 5.8%; etanercept 14.4%; infliximab 23.1%; leflunomide 53.6%; rituximab 3%. After the first year 16...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Augmented reality in neurosurgery.
Authors: Tagaytayan R, Kelemen A, Sik-Lanyi C Abstract Neurosurgery is a medical specialty that relies heavily on imaging. The use of computed tomography and magnetic resonance images during preoperative planning and intraoperative surgical navigation is vital to the success of the surgery and positive patient outcome. Augmented reality application in neurosurgery has the potential to revolutionize and change the way neurosurgeons plan and perform surgical procedures in the future. Augmented reality technology is currently commercially available for neurosurgery for simulation and training. However, the use of augm...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Inhibitory effect of PDGF-BB and serum-stimulated responses in vascular smooth muscle cell proliferation by hinokitiol via up-regulation of p21 and p53.
Conclusions: These data suggest that the anti-proliferative effects of hinokitiol in VSMCs may be mediated by activation of p21 and p53 signaling pathways, and it may contribute to the prevention of vascular diseases associated with VSMC proliferation. PMID: 29765446 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

MicroRNA-141 inhibits proliferation of gastric cardia adenocarcinoma by targeting MACC1.
Conclusions: Our findings demonstrated that miR-141 expression was associated with GCA progression. MACC1, working as one possible target of miR-141, may contribute to the process. MiR-141 is expected to be a potential therapeutic target for the treatment of GCA patients. PMID: 29765447 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Overexpressed HO-1 is associated with reduced STAT3 activation in preeclampsia placenta and inhibits STAT3 phosphorylation in placental JEG-3 cells under hypoxia.
Authors: Qu HM, Qu LP, Li XY, Pan XZ Abstract Introduction: Inadequate trophoblast invasion and placentation are widely believed to contribute to preeclampsia, and multiple lines of evidence indicate the involvement of hypoxia in preeclampsia. However, the molecular mechanisms underlying the association of placental hypoxia with preeclampsia are not clear. Material and methods: The present study focused on the role in preeclampsia of heme oxygenase 1 (HO-1), which is an inducible isoform of HO in response to hypoxia, via examining the expression of HO-1 and the expression and phosphorylation (Tyr705) of Signal ...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Effects of single and combined low frequency electromagnetic fields and simulated microgravity on gene expression of human mesenchymal stem cells during chondrogenesis.
Authors: Mayer-Wagner S, Hammerschmid F, Blum H, Krebs S, Redeker JI, Holzapfel BM, Jansson V, Müller PE Abstract Introduction: Low frequency electromagnetic fields (LF-EMF) and simulated microgravity (SMG) have been observed to affect chondrogenesis. A controlled bioreactor system was developed to apply LF-EMF and SMG singly or combined during chondrogenic differentiation of human mesenchymal stem cells (hMSCs) in 3D culture. Material and methods: An external motor gear SMG bioreactor was combined with magnetic Helmholtz coils for EMF (5 mT; 15 Hz). Pellets of hMSCs (±TGF-β3) were cultured (P5...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Lutein prevents osteoarthritis through Nrf2 activation and downregulation of inflammation.
Conclusions: The present study shows significant cytoprotection offered by lutein against MIA-induced oxidative stress, inflammation and apoptosis by the modulatory effect of NF-κB and Nrf2 activation. PMID: 29765450 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Sequencing of exons 4, 5, 12 of COCH gene in patients with postlingual sensorineural hearing loss accompanied by vestibular lesion.
Conclusions: No cochlin mutations were found in the group of patients with severe to profound sensorineural hearing impairment accompanied by a vestibular lesion. The COCH gene needs further exploration and analysis of genotype-phenotype correlations. PMID: 29765451 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Effects and potential mechanism of atorvastatin treatment on Lp-PLA2 in rats with dyslipidemia.
Authors: Zheng D, Cai A, Xu R, Mai Z, Zhou Y, Zeng F, Li L, Mai W Abstract Introduction: The effects of statins on lipoprotein-associated phospholipase A2 (Lp-PLA2) are controversial, and the present study aimed to investigate whether atorvastatin could reduce Lp-PLA2 in rats with dyslipidemia. Material and methods: A high-fat and high-cholesterol diet was prescribed to produce a dyslipidemia model. Thereafter, low-dose atorvastatin (5 mg/kg/day), high-dose atorvastatin (20 mg/kg/day) or saline (without-treatment group) was prescribed for 14 days. At 6 weeks after dyslipidemia model establishment and 14 days of...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Therapeutic inhibition of CXC chemokine receptor 2 by SB225002 attenuates LPS-induced acute lung injury in mice.
Conclusions: Together, these data demonstrated that inhibition of CXCR2 signaling by SB225002 could ameliorate LPS-induced acute lung injury, by reducing neutrophil recruitment and vascular permeability. SB225002 may be further developed as a potential novel treatment for LPS-induced ALI. PMID: 29765453 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

The effects of ketamine and thiopental used alone or in combination on the brain, heart, and bronchial tissues of rats.
Authors: Ahiskalioglu EO, Aydin P, Ahiskalioglu A, Suleyman B, Kuyrukluyildiz U, Kurt N, Altuner D, Coskun R, Suleyman H Abstract Introduction: We compared the side effects of ketamine and thiopental used alone and of a ketamine/thiopental combination dose on the brain,heart, and bronchial tissues of rats. Material and methods: Three groups received intraperitoneal injections of 30 mg/kg ketamine (K-30); 15 mg/kg thiopental (T-15); or of both in combination (KTSA). These doses were doubled in another set of study groups (K-60, T-30, and KTA groups, respectively). Optimal anesthesia duration was examined in all ...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Ringer's lactate solution enhances the inflammatory response during fluid resuscitation of experimentally induced haemorrhagic shock in rats.
Authors: Kusza K, Mielniczuk M, Krokowicz L, Cywiński JB, Siemionow M Abstract Introduction: Hemorrhagic shock leads to systemic oxygen deficit (hypoxaemia) that results in systemic inflammatory response syndrome (SIRS), a recognised cause of late mortality in this case. The aim of this study was to analyse the impact of fluid resuscitation, using two Ringer solutions, on the microcirculation changes that take place during experimentally induced haemorrhagic shock. Material and methods: A model of the rat cremaster muscle was used to assess microcirculation in vivo. The experimental groups (n = 10 each) includ...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Indomethacin-induced gastric damage in rats and the protective effect of donkey milk.
In this study, we investigated donkey milk's possible protective effect against acute gastric mucosal damage by indomethacin. Material and methods: Four groups, each composed of 8 rats, were created. Rats in the first and third groups were fed with standard rat chow, while those in the second and fourth groups were additionally fed with 25 mg/kg of donkey milk per day via nasogastric gavage. On the 11th day gastric mucosal damage was induced by oral administration of 30 mg/kg of indomethacin to the rats in groups 3 and 4. Six h later all rats were sacrificed and their stomachs were removed for macroscopic and microscop...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

High lncRNA HULC expression is associated with poor prognosis and promotes tumor progression by regulating epithelial-mesenchymal transition in prostate cancer.
Authors: Zheng P, Li H, Xu P, Wang X, Shi Z, Han Q, Li Z Abstract Introduction: Recently, increasing evidence has shown that long non-coding RNAs (lncRNAs) play critical roles in tumor progression and development. However, the expression pattern and biological function of lncRNA HULC (highly upregulated in liver cancer) in prostate cancer (PCa) remain largely unclear. Material and methods: The expression of lncRNA HULC in 53 paired PCa tissues and cell lines was detected by quantitative real-time polymerase chain reaction (qRT-PCR). The χ2 test was used to explore the association of lncRNA HULC expression w...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Analysis of Web-based learning methods in emergency medicine: randomized controlled trial.
Conclusions: The study allowed the interactive course to be identified as the most effective method of distance learning among selected ones. Due to the limitations of the study, we conclude that there is a need for further studies on the effectiveness of e-learning in emergency medicine. PMID: 29765458 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

The number of strata in propensity score stratification for a  binary outcome.
Conclusions: When applying a stratification, more than five strata may be preferable, especially because of increased power. Our simulation study does not show a clear winner; hence a useful strategy could be to work with five as well as with ten strata. PMID: 29765459 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

The role of intestinal microbiota in the pathogenesis of NAFLD: starting points for intervention.
Authors: Vespasiani-Gentilucci U, Gallo P, Picardi A Abstract In recent years, close links between intestinal microbiota and host metabolism have been recognized. Intestinal bacteria can participate in the extraction of calories from food, and circulation of bacterial products, in particular lipopolysaccharides (LPS), is responsible for the "metabolic endotoxemia", which contributes to insulin resistance and its complications, such as non-alcoholic fatty liver disease (NAFLD). Indeed, qualitative and quantitative intestinal dysbiotic changes have been clearly documented in NAFLD patients, and several mech...
Source: Archives of Medical Science - May 17, 2018 Category: General Medicine Tags: Arch Med Sci Source Type: research

Factors influencing P terminal force in lead V1 of the ECG in hemodialysis patients.
Authors: Jaroszyński A, Jaroszyńska A, Dąbrowski W, Zaborowski T, Stepulak A, Iłżecki M, Zubilewicz T Abstract Introduction: Atrial fibrillation (AF) is a highly prevalent arrhythmia in hemodialysis (HD) patients, and an HD session may be a trigger for AF episodes. An abnormal P-terminal force in lead V1 (PTFV1) may predict new-onset AF in HD patients. The aim of the study was to assess the influence of the HD process on PTFV1 and to evaluate possible factors influencing PTFV1 in a group of selected HD patients. Material and methods: One hundred and fifty-three selected HD patients entered the study. Blood...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Depressive symptoms but not chronic pain have an impact on the survival of patients undergoing maintenance hemodialysis.
Conclusions: Chronic pain, although common among hemodialysis patients, did not lower survival. Depressive symptoms are an important predictor for all-cause mortality in hemodialysis patients, with the relationship independent of nutritional or inflammatory status. PMID: 29593798 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Comparison of the efficacy and safety of hybrid and sequential therapies as a first-line regimen for Helicobacter pylori infection in Turkey.
Conclusions: Both therapies are highly effective for eradication of H. pylori, and could be recommended as a first-line therapy in regions with high antibiotic resistance. PMID: 29593799 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Activity of alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase in sera of patients with hepatitis C.
In this study we measured the activity of ADH isoenzymes and ALDH in the sera of patients with hepatitis C. Material and methods: Serum samples were taken from 60 patients suffering from viral hepatitis C and from 66 control subjects. Total ADH activity and class III and IV isoenzymes were measured by the photometric method and ALDH activity, ADH I and II by the fluorometric method. Results: The ADH activity was significantly higher in patients with hepatitis C than in healthy (p
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Inflammatory mediators in the diagnosis and treatment of acute pancreatitis: pentraxin-3, procalcitonin and myeloperoxidase.
Authors: Simsek O, Kocael A, Kocael P, Orhan A, Cengiz M, Balcı H, Ulualp K, Uzun H Abstract Introduction: Acute pancreatitis (AP) is the third most common gastrointestinal disease at hospital admission. The etiology and pathogenesis of this disease are not completely clear. Our study was intended to determine the systemic levels of pentraxin-3 (PTX-3), myeloperoxidase (MPO), procalcitonin (PCT), and C-reactive protein (CRP) as prognostic parameters in early stages of AP. We also determined the effects of treatment on PTX-3, MPO, PCT and CRP levels in AP. Material and methods: The study group comprised 44 AP p...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Oxygen dependence of endothelium-dependent vasodilation: importance in chronic obstructive pulmonary disease.
Authors: Keymel S, Schueller B, Sansone R, Wagstaff R, Steiner S, Kelm M, Heiss C Abstract Introduction: Epidemiological studies have shown increased morbidity and mortality in patients with coronary artery disease (CAD) and chronic obstructive pulmonary disease (COPD). We aimed to characterize the oxygen dependence of endothelial function in patients with CAD and coexisting COPD. Material and methods: In CAD patients with and without COPD (n = 33), we non-invasively measured flow-mediated dilation (FMD) and intima-media thickness (IMT) of the brachial artery (BA), forearm blood flow (FBF), and perfusion of the...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Can we define migraine patients with blood high-sensitivity C-reactive protein and galectin-3 levels in the emergency department?
Authors: Gürger M, Atescelik M, Yilmaz M, Yildiz M, Kalayci H, Kobat MA, Demir CF Abstract Introduction: Migraine, the most widespread cause of headache in young adults, is a frequent reason for presentation to emergency departments. The aim of this study was to determine the diagnostic value of serum galectin-3 and high-sensitivity C-reactive protein (hsCRP) levels in migraine patients. Material and methods: Serum galectin-3 and hsCRP levels were measured using enzyme-linked immunosorbent assay in 70 migraine patients and 70 healthy control subjects. Results: The mean values of hsCRP and galectin-3 le...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

CXCL9 concentrations in cerebrospinal fluid and serum of patients with tick-borne encephalitis.
Authors: Koper OM, Kamińska J, Grygorczuk S, Zajkowska J, Kemona H Abstract Introduction: The aim of our current study was to evaluate cerebrospinal fluid (CSF) and serum CXCL9 concentrations and diagnostic usefulness of this molecule in tick-borne encephalitis (TBE). The study included TBE patients in the acute phase (TBE I) and after 2 weeks of follow-up (TBE II). The control group consisted of patients investigated for suspected central nervous system (CNS) infection, but with normal CSF findings. Material and methods: Concentrations of CXCL9 were measured using enzyme-linked immunosorbent assay (ELISA). ...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Evaluating the introduction of intraoperative neuromonitoring of the recurrent laryngeal nerve in thyroid and parathyroid surgery.
Conclusions: During the initial stages of implementing IONM we experienced technical problems that required correction in every tenth patient. The positive predictive value was relatively low; nevertheless, good results in terms of the rate of accurate identification of the RLN as well as the low rate of RLN paresis support the use of this method. PMID: 29593805 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Consequences of bleeding after thyroid surgery - analysis of 7805 operations performed in a single center.
Authors: Wojtczak B, Aporowicz M, Kaliszewski K, Bolanowski M Abstract Introduction: Surgical treatment of thyroid gland diseases is associated with the possibility of severe complications. The most dangerous of them is bleeding. Current studies focus on its risk factors, rather than reoperation-related consequences. Material and methods: We analyzed 7805 thyroid operations performed from 1996 to 2014 in the Clinic of General, Gastroenterological and Endocrine Surgery of Wroclaw Medical University. Typical risk factors, symptoms and consequences of bleeding were analyzed. Results: Among operated patients 88...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Enhanced healing and anti-inflammatory effects of a carbohydrate polymer with zinc oxide in patients with chronic venous leg ulcers: preliminary results.
Conclusions: The carbohydrate polymer with zinc oxide treatment with venous compression enhances healing of CVUs and improves quality of life due, in part, to its anti-inflammatory properties. PMID: 29593807 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Evaluation of the validity of treatment decisions based on surrogate country models before introduction of the Polish FRAX and recommendations in comparison to current practice.
Conclusions: More patients might have received antiresorptive medication before the Polish FRAX. This study recommends re-evaluation of patients who received medical therapy before the Polish FRAX was introduced and a review of the recommendations, considering the side effects of antiresorptive medication. PMID: 29593808 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The impact of age, sex, blepharitis, rosacea and rheumatoid arthritis on Demodex mite infection.
Authors: Sędzikowska A, Osęka M, Skopiński P Abstract Introduction: Two human-specific Demodex species have been described: Demodex folliculorum and Demodex brevis. A medical condition caused by the presence of Demodex is called demodicosis. Material and methods: The study material comprised eyelashes collected from 1499 patients. Results: Demodex sp. infection was revealed in 47% of patients (487 women and 216 men). We determined the following rates of infection by age groups: 1-25 (8% of infected subjects), 26-40 (36%), 41-55 (50%), 56-70 (67%), over 70 (77%). The sex of the subjects was not identified...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Francisella tularensis/Rickettsia spp. co-infections in patients with skin changes and lymphadenopathy.
Conclusions: The results of our study show that in infections with fever, enlarged lymph nodes and skin lesions after tick and insect bites, laboratory testing of both diseases - SFG rickettsiosis and tularemia - should be implemented. Identification of F. tularensis and Rickettsia spp. mixed infections is crucial in order to administer appropriate antibiotics and to avoid treatment failure and relapse. PMID: 29593810 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Expression of selected genes of dendritic and Treg cells in blood and skin of morphea patients treated with UVA1 phototherapy.
Conclusions: The results do not confirm the involvement of analysed subsets of DC and Tregs in UVA1 phototherapy in morphea, but point to CLEC4C as a possible biomarker associated with the disease activity. PMID: 29593811 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The effect of celastrol on learning and memory in diabetic rats after sevoflurane inhalation.
Authors: Liao WT, Xiao XY, Zhu Y, Zhou SP Abstract Introduction: The aim was to devise an animal model showing some of the neuropathological changes seen in senile dementia, and to investigate the effect of celastrol on cognition neuropathology in this model. Material and methods: Forty male Sprague Dawley rats weighing 300-350 g were randomly divided into 5 groups (n = 8 each): control (Con); inhaled sevoflurane (Sev); diabetes mellitus (DM); diabetes mellitus + inhaled sevoflurane (DM/Sev); diabetes + inhaled sevoflurane + celastrol (Cel). Diabetes was induced by an intraperitoneal injection of streptozotocin...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

The role of vitamin E in the prevention of zoledronic acid-induced nephrotoxicity in rats: a light and electron microscopy study.
In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy. Material and methods: A total of 30 male Sprague-Dawley rats were divided into 3 groups. The first group constituted the control group. The second group was given i.v. ZA of 3 mg/kg once every 3 weeks for 12 weeks from the tail vein. The third group received the same dosage of ZA with an additional i.m. injection of 15 mg Vit-E every week for 12 weeks. Tissues were taken 4 days after the last dose of ZA for histopathological and ultr...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Age-related differences in function and structure of rat livers subjected to ischemia/reperfusion.
Conclusions: The function and structure of mature livers slightly deteriorate with age and these differences are more noticeable under IR conditions. PMID: 29593814 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Preventive effects of total saponins of Panax japonicus on fatty liver fibrosis in mice.
Conclusions: Based on this research, SPJ as a preventive medicine has great potential in prevention of liver fibrosis. PMID: 29593815 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Pancreatic-like enzymes of microbial origin restore growth and normalize lipid absorption in a pig model with exocrine pancreatic insufficiency.
Authors: Pierzynowska K, Valverde-Piedra J, Szymanczyk S, Prykhod'ko O, Pieszka M, Kardas M, Grochowska-Niedworok E, Grabowski T, Winiarczyk M, Pierzynowski S Abstract Introduction: The standard therapy for exocrine pancreatic insufficiency (EPI) is porcine-derived pancreatic enzyme replacement therapy (PERT). In the present study we tested a new approach with a mixture of pancreatic-like enzymes of microbial origin (PLEM) in a 1-week efficacy study in EPI pigs. In addition to the conventionally used coefficient of fat and nitrogen absorption (CFA and CNA), parameters that more accurately reflect the nutritional an...
Source: Archives of Medical Science - March 30, 2018 Category: Biomedical Science Tags: Arch Med Sci Source Type: research