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A comprehensive guidelines-based approach reduces cardiovascular risk in everyday practice: the VARO study.
Authors: Štulc T, Lánská V, Šnejdrlová M, Vrablík M, Prusíková M, Češka R Abstract INTRODUCTION: The aim of study was to investigate the possibility of cardiovascular risk improvement through systematic identification of high-risk individuals and treatment in accordance with current guidelines using modern therapy in daily clinical practice. MATERIAL AND METHODS: Two hundred and sixty-three physicians participated in the study. The physicians were asked to screen for cardiovascular risk factors in patients presenting with unrelated problems and to ...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Mean platelet volume changes before and after glycated hemoglobin (HbA1c) improvement in a large study population.
Authors: Sertbas Y, Sertbas M, Okuroglu N, Ozturk MA, Abacar KY, Ozdemir A Abstract INTRODUCTION: Diabetes mellitus (DM) is a metabolic disorder associated with both microvascular and macrovascular complications. Mean platelet volume (MPV) is a marker of platelet activity, which plays a major role in the development of vascular complications of DM. The aim of this study is to compare the MPV levels before and after the decrease of glycated hemoglobin (HbA1c) levels in a large diabetic population. MATERIAL AND METHODS: This was a retrospective study conducted on type 2 diabetic patients from the outpatient clini...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Beneficial effects of n-3 polyunsaturated fatty acids on adiponectin levels and AdipoR gene expression in patients with type 2 diabetes mellitus: a randomized, placebo-controlled, double-blind clinical trial.
CONCLUSIONS: Daily supplementation with n-3 PUFAs (2.7 g) was effective to significantly improve gene expression of AdipoR1 and AdipoR2 and the serum level of adiponectin in T2DM patients. Therefore, n-3 PUFAs might emerge as an adjuvant for current antidiabetic therapies. However, confirmatory long-term studies are required. PMID: 28721137 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

The effect of orlistat versus metformin on body composition and insulin resistance in obese premenopausal women: 3-month randomized prospective open-label study.
Authors: Kujawska-Łuczak M, Musialik K, Szulińska M, Swora-Cwynar E, Kargulewicz A, Grzymisławska M, Pupek-Musialik D, Bogdański P Abstract INTRODUCTION: Our aim was to evaluate the effects of metformin and orlistat on body composition and glucose-insulin homeostasis in obese premenopausal women. MATERIAL AND METHODS: Seventy-three obese premenopausal Caucasian women aged 32.4 ±8.3 years were treated with either metformin (1000 mg/day; n = 37) or orlistat (360 mg/day; n = 36). Anthropometric parameters were measured using dual-energy X-ray absorptiometry. Glucose tolerance, using the oral glucose tol...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Vitamin D deficiency and non-lipid biomarkers of cardiovascular risk.
Authors: Faridi KF, Lupton JR, Martin SS, Banach M, Quispe R, Kulkarni K, Jones SR, Michos ED Abstract INTRODUCTION: Deficient 25-hydroxyvitamin D (25(OH)D) levels have been associated with dyslipidemia and cardiovascular diseases, though the underlying mechanism of these associations is uncertain. We analyzed associations between vitamin D and other non-lipid biomarkers of cardiovascular risk to better elucidate possible relationships between deficient 25(OH)D and cardiovascular disease. MATERIAL AND METHODS: We performed a cross-sectional analysis of 4,591 adults included in a clinical laboratory database fro...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Serum adipokines and vitamin D levels in patients with type 1 diabetes mellitus.
Authors: Ismail MM, Abdel Hamid TA, Ibrahim AA, Marzouk H Abstract INTRODUCTION: Adiponectin, leptin and resistin are adipokines that play important roles in the regulation of lipid and carbohydrate metabolism in type 2 diabetes (T2DM). However, their influence in type 1 diabetes mellitus is still unknown. The aim of this study was to measure serum adiponectin, leptin and resistin levels and to investigate their relationships with vitamin D and other clinical and laboratory parameters in patients with type 1 diabetes. MATERIAL AND METHODS: Fifty subjects with type 1 diabetes and 50 healthy age- and sex-matched ...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Impact of 25-hydroxyvitamin D, free and bioavailable fractions of vitamin D, and vitamin D binding protein levels on metabolic syndrome components.
Authors: Pelczyńska M, Grzelak T, Sperling M, Bogdański P, Pupek-Musialik D, Czyżewska K Abstract INTRODUCTION: Various forms of vitamin D and factors involved in their metabolism can play a role in the etiopathogenesis of metabolic disorders. This paper aims to define the relationship between concentration of the hydroxylated form of vitamin D (25(OH)D), the fraction of free and bioavailable vitamin D, and of vitamin D binding protein (VDBP) levels on the one hand and the prevalence of metabolic syndrome components on the other. MATERIAL AND METHODS: The studies were conducted on 79 people, including 52 wit...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Maternal lipids associated with large-for-gestational-age birth weight in women with type 1 diabetes: results from a prospective single-center study.
Authors: Gutaj P, Wender-Ożegowska E, Brązert J Abstract INTRODUCTION: Despite improvement in diabetes care over the years, the incidence of macrosomia in type 1 diabetic mothers is still very high and even shows an increasing tendency. It is suggested that other factors that maternal hyperglycemia might be associated with excessive fetal growth in diabetic mothers. The aim of this study was to determine whether maternal lipids might contribute to high rates of large-for-gestational-age (LGA) newborns in women with type 1 diabetes (T1DM). MATERIAL AND METHODS: This prospective, single-center study was perform...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

The effect of antihypertensive treatment on arterial stiffness and serum concentration of selected matrix metalloproteinases.
CONCLUSIONS: In patients with arterial hypertension, beside age and systolic blood pressure, the determinants of arterial stiffness include serum MMP-3 concentration. For drugs compared in the study with the same hypotensive effect obtained, the arterial stiffness reduction effect is not dependent on the drug used. Systolic blood pressure is one of the independent factors responsible for the reduction of arterial stiffness in the course of antihypertensive treatment. PMID: 28721143 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Clinical implications of plasma Nogo-A levels in patients with coronary heart disease.
Authors: Ding Y, Gao BB, Zhou L, Ye XH, Li H, Lai L, Huang JY Abstract INTRODUCTION: Nogo-A is an important neurite growth-regulatory protein in the adult and developing nervous system. Recently, increasing evidence has shown that Nogo-A plays important roles in cardiac development and may act as a potential indicator for heart failure. In addition, increased oxidative stress has been found in individuals with cardiovascular diseases. However, not much is known regarding the expression levels of Nogo-A and reactive oxygen species (ROS) in patients with coronary heart disease (CHD). Therefore, we sought to investiga...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Increased plasma concentrations of interleukin 35 in patients with coronary artery disease.
Authors: Gorzelak-Pabiś P, Chalubinski M, Wojdan K, Luczak E, Duraj I, Mozdzan M, Broncel M Abstract INTRODUCTION: Atherosclerosis leading to coronary artery disease (CAD) is a chronic inflammatory condition. Interleukin 35 (IL-35) released by regulatory T cells (Tregs) has been found to be associated with CAD in the Chinese population. However, nothing is known about the relation between IL-35 concentrations and cholesterol levels. The aim of the study was to assess the levels of IL-35 in CAD patients and healthy subjects from a Caucasian population, and to analyze the relationship between IL-35 and the levels of...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

The role of selected adipokines and ghrelin in the prognosis after myocardial infarction in a 12-month follow-up in the presence of metabolic syndrome.
CONCLUSIONS: The selected adipokines had a good predictive value for the development of adverse cardiac remodeling and for improvement of the ejection fraction among patients after a STEMI in the presence of metabolic syndrome. PMID: 28721146 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

The importance of two metabolic syndrome diagnostic criteria and body fat distribution in predicting clinical severity and prognosis of acute myocardial infarction.
Authors: Jelavic MM, Babic Z, Pintaric H Abstract INTRODUCTION: The interrelation between metabolic syndrome (MetS) (the revised National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF)) and obesity indices in predicting clinical severity and prognosis of acute ST-elevation myocardial infarction (STEMI) is insufficiently known. MATERIAL AND METHODS: This prospective study included 250 acute STEMI patients treated with primary percutaneous coronary intervention. The patients with/without MetS were analyzed by baseline (medical history, demography...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Association of moderate aerobic exercise and rho-associated kinase 2 concentration in subjects with dyslipidemia.
Authors: Bai H, Sun J, Du G, Jiao F Abstract INTRODUCTION: Dyslipidemia is associated with increased rho-associated kinase 2 (ROCK2) concentration. Whether moderate aerobic exercise could attenuate leukocyte ROCK2 concentration is unknown. MATERIAL AND METHODS: One hundred subjects with dyslipidemia and without statin treatment were enrolled and assigned to exercise and control groups. In the exercise group, at least 30 min of moderate aerobic exercise per day 5 times weekly was recommended. In the control group, participants were recommended to undertake exercise of the same intensity as the exercise group but...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Apolipoprotein A1 polymorphisms and risk of coronary artery disease: a meta-analysis.
CONCLUSIONS: The minor allele of the APOA1-75G/A polymorphism is a protective factor for CAD, especially in the studies consistent with HWE. PMID: 28721149 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Phenotype distribution of the paraoxonase gene in patients with cardiac disease.
CONCLUSIONS: We found a higher percentage of RR phenotype in STEMI and HF patients compared to a large control group as well as compared to two other groups of cardiac disease patients. PMID: 28721150 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Moderate-dose atorvastatin improves arterial endothelial function in patients with angina pectoris and normal coronary angiogram: a pilot study.
Authors: Kabaklić A, Fras Z Abstract INTRODUCTION: Endothelial dysfunction could contribute to the pathophysiology of angina pectoris (AP) in patients with normal coronary angiograms. Besides lipid-lowering effects, statins exert pleiotropic effects including improving endothelial function. MATERIAL AND METHODS: Our double-blind study included 58 patients with AP, noninvasively confirmed myocardial ischemia and a normal coronary angiogram. The effect of once-daily 20 mg atorvastatin (A) was compared with placebo (P) for 6 months. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachia...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Clinical SYNTAX Score - a good predictor for renal artery stenosis in acute myocardial infarction patients: analysis from the REN-ACS trial.
Authors: Burlacu A, Siriopol D, Nistor I, Voroneanu L, Nedelciuc I, Statescu C, Covic A Abstract INTRODUCTION: In ST-elevation myocardial infarction (STEMI) patients, multisite artery disease represents a serious issue influencing evolution, outcomes and prognosis. We evaluated for the first time the power of the Myocardial Infarction SYNTAX Score (MI SS) and Clinical SYNTAX Score (MI CSS) as predictors for renal artery stenosis (RAS) in STEMI. We also stratified the study population according to the two scores, and identified the variables correlated with the higher score. MATERIAL AND METHODS: We used data fr...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Fibroblast growth factor 23, iron and inflammation - are they related in early stages of chronic kidney disease?
Authors: Lukaszyk E, Lukaszyk M, Koc-Zorawska E, Bodzenta-Lukaszyk A, Malyszko J Abstract INTRODUCTION: Fibroblast growth factor 23 (FGF-23) levels are elevated in impaired renal function. Inflammation and iron are potential regulators of FGF-23. The aim of the study was to evaluate the association between FGF-23 concentration, novel iron status biomarkers and inflammatory parameters among patients with early stages of chronic kidney disease (CKD). MATERIAL AND METHODS: The study population included 84 patients with CKD in the early stage. Serum hemoglobin, fibrinogen, creatinine, iron, transferrin saturation a...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Obesity and inflammation: the linking mechanism and the complications.
Authors: Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y Abstract Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of d...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Clinical importance of epicardial adipose tissue.
Authors: Nagy E, Jermendy AL, Merkely B, Maurovich-Horvat P Abstract Different visceral fat compartments have several systemic effects and may play a role in the development of both insulin resistance and cardiovascular diseases. In the last couple of years special attention has been paid to the epicardial adipose tissue (EAT), which can be quantified by non-invasive cardiac imaging techniques. The epicardial fat is a unique fat compartment between the myocardium and the visceral pericardium sharing a common embryologic origin with the visceral fat depot. Epicardial adipose tissue has several specific roles, and it...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Obstructive sleep apnea and hormones - a novel insight.
Authors: Ruchała M, Bromińska B, Cyrańska-Chyrek E, Kuźnar-Kamińska B, Kostrzewska M, Batura-Gabryel H Abstract Obstructive sleep apnea (OSA), a disorder characterized by repetitive collapse of the upper respiratory tract during sleep, occurs in about 4% of middle-aged men and 2% of women. The incidence of the disorder is rising due to an increase in obesity and ageing of the population. Patients with obstructive sleep apnea are at elevated risk of some endocrinal and metabolic disorders, which may lead to serious consequences including shortening of life expectancy. The recognition and understanding of intera...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

MicroRNAs and metabolic disorders - where are we heading?
Authors: Sliwinska A, Kasinska MA, Drzewoski J Abstract MicroRNAs (miRNAs, miRs) are short, non-coding molecules engaged in normal functioning of eukaryotic cells, as negative regulators of gene expression. Since the first discovery of miRNA in the early 1990s, hundreds of different miRNAs and their targets have been identified. A growing number of studies have aimed to search for microRNAs which have a key role in the regulation of insulin signaling and metabolic homeostasis. Recent evidence indicates that dysregulation of miRNA expression is involved in the development of various diseases, including type 2 diabet...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Potential novel biomarkers of cardiovascular dysfunction and disease: cardiotrophin-1, adipokines and galectin-3.
Authors: Hogas S, Bilha SC, Branisteanu D, Hogas M, Gaipov A, Kanbay M, Covic A Abstract Cardiovascular disease is one of the main burdens of healthcare systems worldwide. Nevertheless, assessing cardiovascular risk in both apparently healthy individuals and low/high-risk patients remains a difficult issue. Already established biomarkers (e.g. brain natriuretic peptide, troponin) have significantly improved the assessment of major cardiovascular events and diseases but cannot be applied to all patients and in some cases do not provide sufficiently accurate information. In this context, new potential biomarkers that...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

PCSK9 inhibitors - from discovery of a single mutation to a groundbreaking therapy of lipid disorders in one decade.
Authors: Jaworski K, Jankowski P, Kosior DA Abstract Hypercholesterolemia is one of the main risk factors for coronary heart disease and significantly contributes to the high mortality associated with cardiovascular diseases. Statin therapy represents the gold standard in the reduction of low-density lipoprotein cholesterol concentration. Nevertheless, many patients still cannot achieve the recommended target levels, due to either inadequate effectiveness or intolerance of these drugs. Monoclonal antibodies that inhibit proprotein convertase subtilisin/kexin type 9 (PCSK9) have emerged as a promising option in lipi...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Genetic disruption of multidrug resistance-associated protein 1 improves endothelial function and attenuates atherosclerosis in MRP1(-/-) LDLr(-/-) double knockout mice.
Authors: Jehle J, Müller CFH, Aksoy A, Zimmer S, Nickenig G, Tiyerili V Abstract INTRODUCTION: Multidrug resistance-associated protein 1 (MRP1) is an anion transporter which is implicated in the efflux of the intracellular antioxidant anion glutathione as well as leukotrienes. Pharmacological inhibition of MRP1 exhibits antioxidative and anti-atherosclerotic effects both in vitro and in vivo. However, pharmacological inhibitors of MRP1 lack selectivity, which prompted us to study the in vivo impact of a genetic disruption of MRP1 on endothelial dysfunction, reactive oxygen species formation and atherogenesis i...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Repeated positive acceleration exposure exacerbates endothelial dysfunction in high-fat-diet-induced hyperlipidemic rats.
CONCLUSIONS: Repeated +Gz exposure promotes endothelial dysfunction in HFD-induced hyperlipidemic rats. PMID: 28721161 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

The influence of rapamycin on the early cardioprotective effect of hypoxic preconditioning on cardiomyocytes.
Authors: Wang J, Maimaitili Y, Zheng H, Yu J, Guo H, Ma HP, Chen CL Abstract INTRODUCTION: The purpose of this study was to examine the effects of rapamycin on the cardioprotective effect of hypoxic preconditioning (HPC) and on the mammalian target of rapamycin (mTOR)-mediated hypoxia-inducible factor 1 (HIF-1) signaling pathway. MATERIAL AND METHODS: Primary cardiomyocytes were isolated from rat pups and underwent rapamycin and/or HPC, followed by hypoxia/re-oxygenation (H/R) injury. Cell viability and cell injury were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and lactate...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Additive effects of atorvastatin combined with sitagliptin on rats with myocardial infarction: a pilot study.
Authors: Ke X, Ke B, Wang X, Wu S, Yang R, Hu C Abstract INTRODUCTION: Atorvastatin and sitagliptin are able to exert cardio-protective effects. However, whether atorvastatin plus sitagliptin could confer additive benefits for rats with myocardial infarction (MI) is unknown. MATERIAL AND METHODS: Forty rats with MI were produced and 37 surviving rats were randomly divided into atorvastatin (10 mg/kg daily, n = 9), sitagliptin (10 mg/kg daily, n = 9), combined (10 mg/kg daily atorvastatin plus 10 mg/kg daily sitagliptin, n = 9), and control groups (3 ml normal saline daily, n = 10). Fourteen days later, cardiac ...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Influence of half marathon race on aortic stiffness in amateur runners.
Authors: Staniszewska M, Pudło A, Pawlik A PMID: 28721164 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Can coffee consumption lower the risk of Alzheimer's disease and Parkinson's disease? A literature review.
Authors: Wierzejska R Abstract In light of the fact that the number of elderly citizens in society is steadily increasing, the search for dietary factors which might prolong mental agility is growing in significance. Coffee, together with its main ingredient, caffeine, has been the focus of much attention from various researchers, as data on its beneficial effects on human health continue to accumulate. Most reports indicate that moderate coffee consumption may in fact lower the risk for common neurodegenerative conditions, i.e. Alzheimer's and Parkinson's diseases. Regardless, due to their complex pathogenesis as ...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Management of the hormonal syndrome of neuroendocrine tumors.
Authors: Gut P, Waligórska-Stachura J, Czarnywojtek A, Sawicka-Gutaj N, Bączyk M, Ziemnicka K, Fischbach J, Woliński K, Kaznowski J, Wrotkowska E, Ruchała M Abstract Gastroenteropancreatic neuroendocrine tumors (GEP/NET) are unusual and rare neoplasms that present many clinical challenges. They characteristically synthesize store and secrete a variety of peptides and neuroamines which can lead to the development of distinct clinical syndrome, however many are clinically silent until late presentation with mass effects. Management strategies include surgery cure and cytoreduction with the use of somatostat...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Laparoscopic and open liver resection - a literature review with meta-analysis.
Authors: Komorowski AL, Mituś JW, Wysocki WM, Bała MM Abstract INTRODUCTION: In recent years laparoscopic approach to liver resections has gained important attention from surgeons worldwide. The aim of this review was to compare the results of laparoscopic and open liver resections. MATERIAL AND METHODS: We have performed a search in Medline, Embase and the Cochrane Library databases. Studies comparing laparoscopic and open liver resections were included. RESULTS: No randomized clinical trial were identified. In the 16 observational studies included in the analysis there were 927 laparoscopic and 1049 ope...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Comparison of intra-articular versus intravenous application of tranexamic acid in total knee arthroplasty: a meta-analysis of randomized controlled trials.
CONCLUSIONS: In comparison with intravenous application of TXA, intra-articular application had a comparable effect on reducing blood loss and the transfusion rate without increasing the complication rate. PMID: 28507566 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Performance of pfHRP2 versus pLDH antigen rapid diagnostic tests for the detection of Plasmodium falciparum: a systematic review and meta-analysis.
Authors: Li B, Sun Z, Li X, Li X, Wang H, Chen W, Chen P, Qiao M, Mao Y Abstract INTRODUCTION: There have been many inconsistent reports about the performance of histidine-rich protein 2 (HRP2) and lactate dehydrogenase (LDH) antigens as rapid diagnostic tests (RDTs) for the diagnosis of past Plasmodium falciparum infections. This meta-analysis was performed to determine the performance of pfHRP2 versus pLDH antigen RDTs in the detection of P. falciparum. MATERIAL AND METHODS: After a systematic review of related studies, Meta-DiSc 1.4 software was used to calculate the pooled sensitivity, specificity, positive...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Effect of ramipril/hydrochlorothiazide and ramipril/canrenone combination on atrial fibrillation recurrence in hypertensive type 2 diabetic patients with and without cardiac autonomic neuropathy.
Authors: Bosone D, Costa A, Ghiotto N, Ramusino MC, Zoppi A, D'Angelo A, Fogari R Abstract INTRODUCTION: The aim of this study was to compare the effect of ramipril/canrenone versus ramipril/hydrochlorothiazide (HCTZ) combination on atrial fibrillation (AF) recurrence in type 2 diabetic hypertensives with and without cardiac autonomic neuropathy (CAN). MATERIAL AND METHODS: A total of 289 hypertensive type 2 diabetic patients, 95 with CAN, in sinus rhythm but with at least two episodes of AF in the previous 6 months were randomized to ramipril 5 mg plus canrenone 50 mg (titrated to 10/100 mg) or to ramipril 5 m...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Effects of a novel ascorbate-based protocol on infarct size and ventricle function in acute myocardial infarction patients undergoing percutaneous coronary angioplasty.
This study was designed to test the hypothesis that high-dose ascorbate prior to reperfusion followed by low chronic oral doses ameliorate myocardial reperfusion injury (MRI) in acute myocardial infarction patients subjected to primary percutaneous coronary angioplasty (PCA). MATERIAL AND METHODS: A randomized double-blind placebo-controlled and multicenter clinical trial was performed on acute myocardial infarction (AMI) patients who underwent PCA. Sodium ascorbate (320 mmol/l, n = 53) or placebo (n = 46) was infused 30 min prior to PCA. Blood samples were drawn at enrolment (M1), after balloon deflation (M2), 6-8 h a...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

ScaI atrial natriuretic peptide gene polymorphisms and their possible association with postoperative atrial fibrillation - a preliminary report.
CONCLUSIONS: ANP genotype did not predispose to the incidence of "new-onset" AF. PMID: 28507570 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Transcatheter paravalvular leak closure and hemolysis - a prospective registry.
Authors: Smolka G, Pysz P, Ochała A, Kozłowski M, Zasada W, Parma Z, Tendera M, Wojakowski W Abstract INTRODUCTION: Paravalvular leak (PVL) related to a surgical prosthetic valve may be associated with clinically significant hemolysis. The influence of transcatheter PVL closure (TPVLC) on hemolysis remains uncertain. MATERIAL AND METHODS: The prospective registry included patients undergoing TPVLC due to PVL-related heart failure and/or hemolysis. Procedural data, laboratory markers of hemolysis and heart failure status were recorded at baseline, discharge and at 1- and 6-month follow-up. RESULTS: Of 116 ...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Transient dilutional acidosis but no lactic acidosis upon cardiopulmonary bypass in patients undergoing coronary artery bypass grafting.
Authors: Teloh JK, Dohle DS, Sönmez S, Tsagakis K, Verhaegh R, Petersen M, Jakob H, de Groot H Abstract INTRODUCTION: Dilutional acidosis may result from the introduction of a large fluid volume into the patients' systemic circulation, resulting in a considerable dilution of endogenous bicarbonate in the presence of a constant carbon dioxide partial pressure. Its significance or even existence, however, has been strongly questioned. Blood gas samples of patients operated on with standard cardiopulmonary bypass (CPB) were analyzed in order to provide further evidence for the existence of dilutional acidosis. ...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Admission D-dimer testing for differentiating acute aortic dissection from other causes of acute chest pain.
Authors: Li W, Huang B, Tian L, Yang Y, Zhang W, Wang X, Chen J, Sun K, Hui R, Fan X Abstract INTRODUCTION: The present study aims to evaluate the utility of D-dimer testing for differentiating the causes of acute chest pain, including acute aortic dissection (AAD), pulmonary embolism (PE), acute myocardial infarction (AMI), unstable angina (UA), and other uncertain diagnoses of chest pain. MATERIAL AND METHODS: Consecutive patients admitted for acute chest pain within 24 h from symptom onset were enrolled prospectively, and plasma D-dimer levels were measured on admission. Diagnoses of AAD, PE, AMI, and UA wer...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Blood groups and acute aortic dissection type III.
CONCLUSIONS: Our results indicated no difference between different blood groups and RhD typing with respect to in-hospital mortality of patients with acute aortic dissection type III. PMID: 28507574 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Association between telomere length and complete blood count in US adults.
CONCLUSIONS: These results support the possibility that telomere attrition may be a marker for reduced proliferative reserve in hematopoietic progenitor cells. PMID: 28507575 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Red blood cell distribution width in patients with limb, chest and head trauma.
This study investigated the values of red blood cell distribution width (RDW), an emerging and independent predictor of morbidity and mortality, in patients with limb, chest and head trauma. MATERIAL AND METHODS: The study sample consisted of all patients who attended the emergency department (ED) of the University Hospital of Parma for limb, chest and head traumas requiring admission to hospital wards during the year 2014. The controls consisted of outpatients living in the same geographical area and undergoing routine laboratory testing for health check-up. RESULTS: The final study sample consisted of 290 patient...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Peritoneal lavage examination as a prognostic tool in cases of gastric cancer.
Authors: Hoskovec D, Varga J, Dytrych P, Konecna E, Matek J Abstract INTRODUCTION: Peritoneal tumor seeding is a common form of recurrence after gastric cancer surgery. The finding of free tumor cells and/or elevation of tumor markers in the peritoneal fluid could predict intraperitoneal tumor recurrence. The results of these examination can be used for indication of aggressive treatment modalities such as hyperthermic intraperitoneal chemotherapy (HIPEC). MATERIAL AND METHODS: We have operated on 105 patients suffering from gastric cancer. The control group consisted of 12 patients without malignant disease. P...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Lobular carcinoma in situ of the breast - correlation between minimally invasive biopsy and final pathology.
CONCLUSIONS: Pleomorphic histology, mass formation and BIRADS 5 category reflect more aggressive behaviour of LCIS and identify patients who need subsequent surgery. For other patients, close follow-up could be a safe alternative. PMID: 28507578 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Assessment of concentrations of sTRAIL ligand and its receptors sTRAIL-R1 and sTRAIL-R2 - markers monitoring the course of the extrinsic pathway of apoptosis induction: potential application in ovarian cancer diagnostics.
CONCLUSIONS: The state of immunosuppression accompanying neoplastic disease depends on the extrinsic pathway of apoptosis induction in the TRAIL/TRAIL-R system. Determination of TRAIL-R1 and TRAIL-R2 levels may prove to be useful in ovarian tumor differential diagnostics, which requires further research. PMID: 28507579 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Impact of antenatal oxytocin infusion on neonatal respiratory morbidity associated with elective cesarean section.
CONCLUSIONS: Neonatal respiratory morbidity associated with ECS significantly decreased after antenatal oxytocin exposure. A significant reduction of neonatal respiratory morbidity would be achieved if ECS were performed after 39 weeks' gestation. PMID: 28507580 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Long-term outcomes in children with chronic kidney disease stage 5 over the last 40 years.
Authors: Adamczuk D, Roszkowska-Blaim M Abstract INTRODUCTION: We evaluated outcomes in children with chronic kidney disease stage 5 (CKD 5) treated in the first pediatric dialysis unit in Poland during 1973-2012. MATERIAL AND METHODS: The retrospective analysis included 208 children with CKD 5 undergoing renal replacement therapy (RRT), stratified into four decades of treatment: 1973-1982, 1983-1992, 1993-2002, and 2003-2012. RESULTS: The most common causes of CKD 5 included glomerulonephritis in 27.4% and pyelonephritis secondary to urinary tract anomalies in 25.5% of children. Among 208 children, 172 (82...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research

Decreased activity of butyrylcholinesterase in blood plasma of patients with chronic obstructive pulmonary disease.
Authors: Sicinska P, Bukowska B, Pajak A, Koceva-Chyla A, Pietras T, Nizinkowski P, Gorski P, Koter-Michalak M Abstract INTRODUCTION: Butyrylcholinesterase (BChE) is involved in the metabolism of endogenous lipids and xenobiotics, such as esters of carboxylic or phosphoric acids. Butyrylcholinesterase activity is associated with both inflammation and oxidative stress. Changes in the activity of this enzyme have been observed in various diseases such as liver cirrhosis, diabetes, neurodegenerative disease and others. MATERIAL AND METHODS: The study involved 30 patients with chronic obstructive pulmonary disease ...
Source: Archives of Medical Science - May 17, 2017 Category: Biomedical Science Tags: Arch Med Sci Source Type: research