[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research

Erdheim ‑Chester disease of multisystem involvement with delayed diagnosis: A case report and literature review
Exp Ther Med. 2024 Feb 22;27(4):159. doi: 10.3892/etm.2024.12447. eCollection 2024 Apr.ABSTRACTErdheim-Chester disease (ECD) is a rare tumor of histiocytic origin, characterized by foamy or lipid-laden histiocytes mixed or surrounded by fibrosis that infiltrate multiple organs. Misdiagnosis is common due to the diversity of clinical presentations. The present study reported a case of ECD with the involvements of bone, cardiac, aorta and retroperitoneum. The patient had no obvious clinical symptoms and no noteworthy foamy histiocytes or Touton giant cells were found on pathological examination, delaying the diagnosis. The p...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiaotong Shi Guangzhi Sun Tongguan Li Mengjiao Xu Yixuan Liu Zhankui Wang Yanfeng Hou Source Type: research

Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research

Paclitaxel mediates the PI3K/AKT/mTOR pathway to reduce proliferation of FLT3 ‑ITD < sup > + < /sup > AML cells and promote apoptosis
Exp Ther Med. 2024 Feb 23;27(4):161. doi: 10.3892/etm.2024.12449. eCollection 2024 Apr.ABSTRACTAcute myeloid leukemia (AML) with internal tandem duplication (ITD) mutations in the FLT3 tyrosine kinase tend to have a poor prognosis. FLT3-ITD can promote the progress of AML by activating the PI3K/AKT/mTOR pathway. Paclitaxel (PTX) is a natural anticancer drug that has been widely used in chemotherapy for multiple malignancies. The present study used the CCK-8 assay, flow cytometry, PCR and western blotting to explore the anti-leukemia effect and possible mechanisms of PTX on MV4-11 cells with the FLT3-ITD mutation and the un...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yanyun Su Meiqing Wu Baowen Zhou Ziwen Bai Ruli Pang Zhenfang Liu Weihua Zhao Source Type: research

Sex differences in diabetes ‑induced hepatic and renal damage
In conclusion, the present study characterized the features of liver and kidney damage in db/db mice and indicated that sex differences should be taken into account in experiments using female and male experimental animals. Furthermore, sex differences should be taken into account in the selection of drug interventions in experiments and in clinical drug therapy.PMID:38476888 | PMC:PMC10928993 | DOI:10.3892/etm.2024.12436 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Linghuan Gao Xindi Wang Lei Guo Wenli Zhang Gengyin Wang Shuying Han Yuxin Zhang Source Type: research

Mitochondrial calcium uniporter promotes mitophagy by regulating the PINK1/Parkin pathway in caerulein ‑treated pancreatic ductal epithelial cells < em > in < /em >   < em > vitro < /em >
In conclusion, an activated MCU may promote mitophagy by regulating the PINK1/Parkin pathway in PDECs in AP.PMID:38476889 | PMC:PMC10928816 | DOI:10.3892/etm.2024.12435 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yu Lei Hui-Ying Yang Nuo Meng Ying-Ying Qin Meng-Tao Xu Xue-Lian Xiang Li Liu Guo-Du Tang Source Type: research

Erratum: [Corrigendum] miR ‑216a‑5p acts as an oncogene in renal cell carcinoma
Exp Ther Med. 2024 Feb 21;27(4):155. doi: 10.3892/etm.2024.12443. eCollection 2024 Apr.ABSTRACT[This corrects the article DOI: 10.3892/etm.2018.5881.].PMID:38476890 | PMC:PMC10928975 | DOI:10.3892/etm.2024.12443 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Peijie Chen Jing Quan Lu Jin Canbin Lin Weijie Xu Jinling Xu Xin Guan Zebo Chen Liangchao Ni Shangqi Yang Yun Chen Yongqing Lai Source Type: research

Predictive nomogram models for atrial fibrillation in COPD patients: A comprehensive analysis of risk factors and prognosis
Exp Ther Med. 2024 Feb 28;27(4):171. doi: 10.3892/etm.2024.12459. eCollection 2024 Apr.ABSTRACTThe aim of the present study was to identify the independent risk factors and prognostic indicators for atrial fibrillation (AF) in patients with chronic obstructive pulmonary disease (COPD) and to develop predictive nomogram models. This retrospective study included a total of 286 patients with COPD who were admitted to the Second Affiliated Hospital of Guilin Medical College between January 2020 and May 2022. The average age of the patients was 77.11±8.67 years. Based on the presence or absence of AF, the patients were divided...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Tao Huang Xingjie Huang Xueying Cui Qinghua Dong Source Type: research

Biochanin A inhibits endothelial dysfunction induced by IL ‑6‑stimulated endothelial microparticles in Perthes disease via the NFκB pathway
Exp Ther Med. 2024 Feb 13;27(4):137. doi: 10.3892/etm.2024.12425. eCollection 2024 Apr.ABSTRACTEndothelial dysfunction caused by the stimulation of endothelial microparticles (EMPs) by the inflammatory factor IL-6 is one of the pathogenic pathways associated with Perthes disease. The natural active product biochanin A (BCA) has an anti-inflammatory effect; however, whether it can alleviate endothelial dysfunction in Perthes disease is not known. The present in vitro experiments on human umbilical vein endothelial cells showed that 0-100 pg/ml IL-6-EMPs could induce endothelial dysfunction in a concentration-dependent manne...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Jianhong Liu Chengsen Lin Boxiang Li Qian Huang Xianxiang Chen Shengping Tang Xiaolin Luo Rongbin Lu Yun Liu Shijie Liao Xiaofei Ding Source Type: research

Transcriptomic analysis of lipoteichoic acid ‑treated undifferentiated and neutrophil‑like differentiated HL‑60 cells
Exp Ther Med. 2024 Feb 22;27(4):158. doi: 10.3892/etm.2024.12446. eCollection 2024 Apr.ABSTRACTToll-like receptor 2 (TLR2) is an important sensor for innate immune cells, including neutrophils, for the recognition of pathogen infection. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is a TLR2 ligand. LTA-induced TLR2 signaling pathways are well established in neutrophils. However, experimental studies regarding transcriptional regulation and the molecular mechanisms in primary human neutrophils are limited due to their short lifespan. The promyelocytic leukemia cell line, HL-60, can differentiate...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Kuan-Ting Liu I-Jeng Yeh Ya-Ling Hsu Meng-Chi Yen Source Type: research

Effect of tofacitinib on the phenotype and activity of Caco ‑2 cells in a model of inflammatory bowel disease
In conclusion, the inhibitory effects of tofacitinib on oxidative stress, as well as its anti-apoptotic and regenerative effects, provide important information regarding the positive effect of tofacitinib on Caco-2 cells, and therefore constitute potential information about the beneficial effect of the evaluated drug in UC.PMID:38476894 | PMC:PMC10928998 | DOI:10.3892/etm.2024.12440 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Estera Skudrzyk Łukasz Bułdak Grzegorz Machnik Bogus ław Okopień Source Type: research

Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence ‑based practice
Exp Ther Med. 2024 Feb 28;27(4):173. doi: 10.3892/etm.2024.12461. eCollection 2024 Apr.ABSTRACTThe dose-dependent pharmacological response to dapagliflozin in patients with type 2 diabetes mellitus (T2DM) with regard to weight loss remain unknown. The aim of the present study was to investigate the effects of dapagliflozin on weight loss in patients with T2DM. A total of 8,545 patients with T2DM from 24 randomized controlled trials reported in the literature were selected for inclusion in the study. Data from these trials were analyzed using maximal effect (Emax) models with nonlinear mixed effects modeling; the evaluation...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yan Han Ya-Feng Li Chao-Wei Ye Yao-Yang Gu Xiao Chen Qian Gu Qiang-Qiang Xu Xian-Ming Wang Su-Mei He Dong-Dong Wang Source Type: research

Antibiotic administration aggravates asthma by disrupting gut microbiota and the intestinal mucosal barrier in an asthma mouse model
Exp Ther Med. 2024 Feb 21;27(4):157. doi: 10.3892/etm.2024.12445. eCollection 2024 Apr.ABSTRACTIn humans, gut microbiota can determine the health status. The regulatory mechanisms of the gut microbiota in asthma must be elucidated. Although antibiotics (ABXs) can clear infections, they markedly alter the composition and abundance of gut microbiota. The present study used ABX-treated mice to examine the time-dependent effects of ABX administration on the gut microbiota and intestinal mucosal barrier. The mouse asthma model was established using ovalbumin (OVA) and gavaged with an ABX cocktail for different durations (1 or 2...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Cheng-Ling Xu Cui Wang Gao-Bin Li Tong Zhao Rui-Ling Zhou Jing Chen Source Type: research

Meta ‑analysis of the efficacy of venetoclax and azacitidine combination therapy and azacitidine monotherapy for treating acute myeloid leukemia
In conclusion, the combination of venetoclax and azacitidine was more effective than azacitidine alone, and had a good clinical application value in the treatment of AML. Although some adverse reactions occurred in response to the combination therapy, they did not significantly affect the prognosis of AML. To better evaluate the efficacy and safety of this treatment regimen, multicenter clinical studies with larger sample sizes are required.PMID:38476897 | PMC:PMC10928973 | DOI:10.3892/etm.2024.12452 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yuqin Xie Xueqin Wei Weiwei Wang Changsheng Liao Pengfei Han Yanhui Yu Source Type: research

CHL1 inhibits cell proliferation, migration and invasion by regulating the NF ‑κB signaling pathway in colorectal cancer
Exp Ther Med. 2024 Feb 26;27(4):165. doi: 10.3892/etm.2024.12454. eCollection 2024 Apr.ABSTRACTCell adhesion molecule close homolog of L1 (CHL1) is implicated in tumorigenesis of various malignancies. However, its role and underlying molecular mechanisms in colorectal cancer (CRC) remain unclear. The present study aimed to evaluate the specific biological functions and mechanisms of CHL1, in order to provide a theoretical basis for the use of CHL1 as a biological target in CRC. CHL1 expression was originally determined in CRC cell lines. Subsequently, CHL1 overexpression was induced by plasmid transfection in HT29 and SW48...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Ming Bao Shenglong Li Yu Zhu Xiaoyu Dong Ran Wang Fangyan Jing Source Type: research