"Exp Ther Med"[ta]; +104 new citations
104 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Exp Ther Med"[ta] These pubmed results were generated on 2020/02/06PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites. (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - February 6, 2020 Category: General Medicine Tags: Report Source Type: research

miR-224-5p protects dental pulp stem cells from apoptosis by targeting Rac1.
Authors: Qiao W, Li D, Shi Q, Wang H, Wang H, Guo J Abstract Dental pulp stem cells (DPSCs) are reported to be enriched in stem/progenitor cells, however to the best of our knowledge they have yet to be well documented and characterized. In the present study, in order to characterize DPSCs and the effect of microRNAs (miRs/miRNAs) on DPSC properties, a miRNA array was performed between dental periodontal ligament cells (DPLCs) and DPSCs. The results revealed that miR-224-5p (miR-224) was highly expressed in the DPSCs compared with that in the DPLCs. The transfection of DPSCs with an miR-224 inhibitor impaired cell ...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Erratum: Identification of lncRNA competitively regulated subpathways in myocardial infarction.
Authors: Wu X, Sun L, Wang Z Abstract [This corrects the article DOI: 10.3892/etm.2019.7320.]. PMID: 31897094 [PubMed - in process] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Comparison of four different internal fixation methods in the treatment of distal clavicle fractures.
This study compared the clinical efficacy of four internal fixation methods in the treatment of distal clavicle fractures, in an effort to guide appropriate selection and application in the clinic. Eighty-four patients with distal clavicle-comminuted fractures were treated with a distal clavicle anatomic plate (group A), clavicular hook plate (group B), double-plate vertical fixation (group C), or T-shaped steel plate internal fixation (group D). The Constant-Murley scoring system was used to evaluate the shoulder joint function. The fracture healing time, VAS, and postoperative complications were compared and analyzed amo...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

MicroRNA-150 functions as a tumor suppressor and sensitizes osteosarcoma to doxorubicin-induced apoptosis by targeting RUNX2.
Authors: Ling Z, Fan G, Yao D, Zhao J, Zhou Y, Feng J, Zhou G, Chen Y Abstract Osteosarcoma (OS) is the most common form of bone malignancy in children and adolescents. MicroRNAs (miRNAs) have been associated with the development and progression of OS. In the present study, reverse transcription-quantitative PCR, western blotting, Cell Counting Kit-8, luciferase and Transwell assays were performed to investigate the biological function of microRNA-150 (miR-150) in OS. The results revealed that miR-150 was significantly downregulated in OS cell lines (HOS, SAOS2, MG-63 and U2OS) in comparison with the normal osteobl...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Identification of differentially expressed genes in the endothelial precursor cells of patients with type 2 diabetes mellitus by bioinformatics analysis.
Authors: Shen Z, Chen Q, Ying H, Ma Z, Bi X, Li X, Wang M, Jin C, Lai D, Zhao Y, Fu G Abstract Type 2 diabetes mellitus (DM) is a metabolic disease with worldwide prevalence that is associated with a decrease in the number and function of endothelial progenitor cells (EPCs). The aim of the present study was to explore the potential hub genes of EPCs in patients with type 2 DM. Differentially expressed genes (DEGs) were screened from a public microarray dataset (accession no. GSE43950). Pathway and functional enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Expression and short-term prognostic value of miR-126 and miR-182 in patients with acute stroke.
Authors: Qi R, Liu H, Liu C, Xu Y, Liu C Abstract Expression and short-term prognostic value of miR-126 and miR-182 in patients with acute stroke were investigated. In total, 153 patients with acute stroke admitted to the Second Affiliated Hospital of Soochow University from February 2016 to February 2018 were enrolled into the observation group as group A [88 patients with acute cerebral infarction (AIS)] or group B [65 patients with cerebral hemorrhage (ICH)]. Furthermore, 69 healthy people receiving physical examinations in the hospital were enrolled into the control group. The relative expression of miR-126 and...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

The preventive effect of Apocynum venetum polyphenols on D-galactose-induced oxidative stress in mice.
In conclusion, AVP exhibited an antioxidant effect and the AVP-rich Apocynum venetum may be considered a plant resource with potential antioxidative benefits. PMID: 31897099 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effects of simvastatin-loaded PLGA microspheres on treatment of rats with intervertebral disk degeneration and on 6-K-PGF1 α and HIF-1α.
Effects of simvastatin-loaded PLGA microspheres on treatment of rats with intervertebral disk degeneration and on 6-K-PGF1α and HIF-1α. Exp Ther Med. 2020 Jan;19(1):579-584 Authors: Zhu K, Zhao F, Yang Y, Mu W Abstract Effects of simvastatin-loaded PLGA sustained release microspheres on the treatment of rats with intervertebral disk degeneration (IVDD) and on 6-keto-prostaglandin F1α (6-K-PGF1α) and hypoxia inducible factor-1α (HIF-1α) were investigated. Eighty female rats were selected and randomized into a model group (modeled for IVDD), a treatment group (modeled ...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Relationship between changes of electrocardiogram indexes in chronic heart failure with arrhythmia and serum PIIINP and BNP.
Authors: Wang Y, Ma X Abstract Relationship between changes of electrocardiogram (ECG) indexes in chronic heart failure (CHF) with arrhythmia and serum type III procollagen amino-terminal peptide (PIIINP) and brain natriuretic peptide (BNP) were evaluated. From December 2017 to December 2018, 101 patients with heart failure (HF) were collected. Among them, 48 patients with HF and slow arrhythmia were in group A, and 53 cases of HF with non-slow arrhythmia were sin group B, including 33 males and 20 females. BNP was detected by chemiluminescence and PIIINP was detected by immunoassay. The changes of ECG indexes in t...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Imatinib inhibits oxidative stress response in spinal cord injury rats by activating Nrf2/HO-1 signaling pathway.
Authors: Liu L, Zhou J, Wang Y, Qi T, Wang Z, Chen L, Suo N Abstract Effect of imatinib on rats with spinal cord injury (SCI) was investigated through the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway. Forty-eight Sprague-Dawley rats were randomly divided into sham operation group (n=12), model group (n=12), imatinib group (n=12) and inhibitor group (n=12). The results of immunohistochemistry showed that in comparison with sham operation group, the other three groups had overtly increased positive expression level of Bax and evidently reduced positive expression level of Bcl-2 (P
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Upregulated miRNA-182-5p expression in tumor tissue and peripheral blood samples from patients with non-small cell lung cancer is associated with downregulated Caspase 2 expression.
Authors: Yang L, Dou Y, Sui Z, Cheng H, Liu X, Wang Q, Gao P, Qu Y, Xu M Abstract Lung cancer has the highest morbidity and mortality rates among all malignant tumors worldwide. Previous studies demonstrated that microRNA (miR)-182-5p may serve different roles in different types of cancer, including renal cell carcinoma and liver cancer. However, the functional role of miR-182-5p in non-small cell lung cancer (NSCLC) remains unknown. In the current study, the expression level of miR-182-5p in tumor tissue and peripheral blood samples obtained from patients with NSCLC was examined. The biological function of miR-182...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

MRI and pathological features of Rathke cleft cysts in the sellar region.
Authors: Wang S, Nie Q, Wu Z, Zhang J, Wei L Abstract The aim of the present study was to investigate the MRI and pathological features of Rathke cleft cysts (RCC) in the sellar region. A total of 45 RCC cases were retrospectively analyzed. RCC size, location, intracyst nodules and general signals, as well as the posterior pituitary bright spot (PPBS) were analyzed using MRI-T1 weighted images (T1WI) and T2WI. The relationship between the presence of PPBS and histopathological features was additionally evaluated. On T1WI, there were 18 cases of isointense signal, 16 cases of hyperintense signal, 9 cases of hypointe...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effectiveness and safety of common therapeutic drugs for refractory lupus nephritis: A network meta-analysis.
In conclusion, the regimen of CTX + TAC + GC exhibited a trend in superiority regarding clinical efficacy among common therapeutic drug treatments for RLN, while the regimen of CTX + GC had a higher probability to cause adverse effects among the nine interventions compared. PMID: 31897105 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Expression and correlation of Chemerin and FABP4 in peripheral blood of gestational diabetes mellitus patients.
In conclusion, Chemerin and FABP4 were upregulated in the peripheral blood of GDM patients. There was a positive correlation between the two and a positive correlation with the inflammatory factors IL-6 and TNF-α. PMID: 31897106 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effect of silicone oil on macular capillary vessel density and thickness.
In conclusion, silicone oil has no significant effect on macular capillary vessel density within a 6-month period but may compress and reduce the thickness of the inner retina. PMID: 31897107 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Identification of an activation-related protein in B cells in the ABO incompatible condition.
Authors: Cao J, Chen C, Liu L, Zhang Y, Zhou H, Xiao J, Wang Y Abstract In ABO-incompatible (ABOi) kidney transplantation (KT), antibodies can mediate immunological accommodation or immune rejection, but the mechanism by which B cells are induced to produce antibodies with different functions is still unclear. Previous research established an ABOi kidney cell model and identified that haptoglobin (HP) is associated with the activation of lymphocytes. In the present study, the results of a flow cytometric assay demonstrated that HP was expressed by B cells. Moreover, dot-ELISA and ELISA analyses showed that the conc...
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Erratum: Expression and role of lncRNAs in the regeneration of skeletal muscle following contusion injury.
Authors: Zheng L, Liu X, Chen P, Xiao W Abstract [This corrects the article DOI: 10.3892/etm.2019.7871.]. PMID: 31897109 [PubMed - in process] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - January 4, 2020 Category: General Medicine Tags: Exp Ther Med Source Type: research

Current status and research progress of minimally invasive surgery for flail chest.
Authors: Xia H, Zhu D, Li J, Sun Z, Deng L, Zhu P, Zhang Y, Li X, Wang D Abstract Chest trauma accounts for ~13.5% of all traumas, and direct death from chest trauma accounts for 20-25% of all traumatic deaths. Chest trauma is the second cause of death from trauma. Frequent rib fractures, especially in patients with flail chest, often cause severe pain, chest wall softening, abnormal breathing and severe lung contusion and laceration, usually requiring thoracic surgery. In recent years, the open reduction and internal fixation treatment of rib fractures with flail chest has achieved satisfactory results, and some s...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effects of cardiopulmonary bypass on the development of lymphopenia and sepsis after cardiac surgery in children with congenital cardiopathy.
The objective of the present study was to investigate whether lymphopenia occurring after heart surgery with cardiopulmonary bypass (CPB) is related to apoptosis and or sepsis in children. The design was a prospective cohort study in a third level care hospital in Mexico City. In total, 68 children (31 girls and 37 boys) with congenital cardiopathy who needed corrective cardiac surgery with or without CPB were included. The samples were obtained from central blood before, immediately after and 24 h after surgery. Complete blood counts and lymphocyte apoptosis were analyzed. Systemic inflammatory response syndrome (SIRS), s...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

ΜicroRNA-221 participates in cerebral ischemic stroke by modulating endothelial cell function by regulating the PTEN/PI3K/AKT pathway.
In conclusion, miR-221 was downregulated in CIS patients, and it promoted the function of HUVECs by regulating the PTEN/PI3K/AKT pathway in vitro, suggesting the ability to promote angiogenesis. Therefore, miR-221 may be a novel and promising therapeutic target for CIS treatment. PMID: 31885694 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

MicroRNA-1236-3p/translationally controlled tumor protein (TPT1) axis participates in congenital hypothyroidism progression by regulating neuronal apoptosis.
Authors: Meng T, Shen S, Li C, Liu X Abstract Congenital hypothyroidism (CH) is an endocrine disease caused by congenital thyroid hormone (TH) deficiency. MicroRNAs (miRNAs or miRs) have been reported to inhibit the progression of congenital hypothyroidism. However, the expression and role of miR-1236-3p in CH remains unclear. To address this, 12 day old Sprague-Dawley rats were divided into five groups: Control; Congenital hypothyroidism (CH), miR-1236-3p inhibitor control (inhibitor control); miR-1236-3p inhibitor (inhibitor); and miR-1236-3p inhibitor + translationally-controlled tumor protein 1 (TPT1)-small int...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Color-coded duplex sonography vs. 3.0 Tesla magnetic resonance angiography for detection of intracranial stenosis of the internal carotid artery: A prospective cohort study.
Authors: Xiao L, Chu W, Wang H Abstract Hemodynamic changes may provide important information for clinical decision-making in internal carotid artery (ICA) stenosis. The degree of stenosis is responsible for the hemodynamic changes. For detection of intracranial stenosis, each diagnostic method has its own advantages and disadvantages. The goal of the present study was to compare the sensitivity and accuracy of color-coded duplex sonography with that of magnetic resonance angiography (MRA) for the detection of intracranial stenosis. Patients with 3 vessels and/or left stem coronary artery disease were subjected to ...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Pulmonary protection of transcutaneous electrical acupoint stimulation in gynecological laparoscopic surgery: A randomized controlled trial.
Authors: Wei W, Bai W, Yang Y, Li Y, Teng X, Wan Y, Zhu J Abstract Laparoscopy is performed worldwide due to its limited side effects and optimal treatment efficacy. However, it also has adverse effects, including atelectasis and ischemia-reperfusion injury, due to CO2 accumulation during ventilation in a head-down position, which may result in severe disorders and adversely affecting postoperative recovery, prolonging hospitalization. The present study was performed to assess whether transcutaneous electrical acupoint stimulation (TEAS) protects against lung injury occurring during gynecological laparoscopic surge...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Efficacy, safety and prognosis of treating neurological deficits caused by spinal tuberculosis within 4 weeks' standard anti-tuberculosis treatment: A single medical center's experience.
Authors: Jia CG, Gao JG, Liu FS, Li Z, Dong ZL, Yao LM, Wang LB, Yao XW Abstract The present study aimed to retrospectively analyze the safety and efficacy of the early surgical management of thoracic tuberculosis (TB) in patients with neurological deficits. The medical data of patients with thoracic TB exhibiting neurological deficit in the Chest Hospital of Hebei Province were retrospectively reviewed. A total of 234 cases, including 123 males and 115 females, were recruited in the present study. Their pre- and postoperative neurological deficit and pain levels were assessed using the 2002 American spinal injury ...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Umbilical cord blood troponin I, myoglobin and CK-MB in neonatal hypoxic ischemic encephalopathy and the clinical significance.
Authors: Wan B, Pan X, Ma J, Luo Y, Liu J, Zhao G Abstract Associations of serum S-100β, cystatin C (Cys-C) and C-reactive protein (CRP) with umbilical cord blood troponin I (TnI), myoglobin (Mb) and creatine kinase-MB (CK-MB) in neonatal hypoxic ischemic encephalopathy (NHIE) and the clinical significance were explored. A total of 40 patients with NHIE treated in the Binzhou Medical University Hospital were selected as observation group, while another 40 healthy neonates in the same period were selected as control group. The related data of all subjects were collected, and the levels of serum S-100β prot...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Effects of etanercept and infliximab on bone metabolism indexes in patients with ankylosing spondylitis.
Authors: Wang C, Li W Abstract Effect of etanercept and infliximab on bone metabolism indexes in patients with ankylosing spondylitis (AS) were evaluated. The clinical data of 80 patients with ankylosing spondylitis admitted to Affiliated Hospital of Hebei University of Engineering from June 2015 to March 2016 were selected. There were 39 patients treated with Enbrel as Enbrel group and 41 patients treated with Infliximab as Infliximab group. The general data of the two groups of patients were collected and various indexes before and 12 and 24 weeks after treatment were recorded. Adverse reactions of the two groups...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Inhibition of the leucine-rich repeat protein lingo-1 enhances RGC survival in optic nerve injury.
Authors: Quan Y, Wu Y, Zhan Z, Yang Y, Chen X, Wu K, Yu M Abstract Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (lingo-1) is selectively expressed on neurons and oligodendrocytes in the central nervous system and acts as a negative regulator in neural repair, implying a potential role in optic neuropathy. The aim of the present study was to determine whether adeno-associated virus serotype 2 (AAV2) vector-mediated transfer of lingo-1 short hairpin RNA could reduce nerve crush-induced axonal degeneration and enhance axonal regeneration following optic nerve (ON) i...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Prospective analysis of the efficacy of beraprost sodium combined with alprostadil on diabetic nephropathy and influence on rennin-angiotensin system and TNF- α.
Prospective analysis of the efficacy of beraprost sodium combined with alprostadil on diabetic nephropathy and influence on rennin-angiotensin system and TNF-α. Exp Ther Med. 2020 Jan;19(1):639-645 Authors: Xu X, Pan X, Li S Abstract Efficacy of beraprost sodium (BPS) combined with alprostadil on diabetic nephropathy (DN) and its influence on renin angiotensin system (RAS) and TNF-α were investigated. One hundred and two patients with type 2 diabetic nephropathy admitted to Weifang People's Hospital from July 2017 to January 2019 were selected and divided into two groups according to the tr...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage.
Authors: Cai Z, Zhang H, Song H, Piao Y, Zhang X Abstract Effects of edaravone combined with cinepazide maleate on neurocyte autophagy and neurological function in rats with subarachnoid hemorrhage were investigated. Eighty SD rats were selected to establish subarachnoid hemorrhage (SAH) rat models, which were divided into sham operation group, SAH group, MCI group and combined group. Hippocampal tissue of each group was taken to observe the number of neurocytes. The expression levels of Beclin-1 and (light chain LC3)-II of rats in each group were detected by ELISA. Pearson's correlation factors were used to analyz...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Imaging and treatment of idiopathic abdominal cocoon in 9 patients.
In conclusion, CT may be highly valuable in the preoperative diagnosis of AC. PMID: 31885704 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Downregulated miRNA-324-5p aggravates neuronal injury induced by oxygen-glucose deprivation via modulating RAN.
Authors: Gu J, Gui S, Hu L, Kong L, Di M, Wang Y Abstract Differentially expressed miRNAs in the GEO profile of ischemic stroke were analyzed to clarify the specific role of microRNA-324-5p (miRNA-324-5p) in ischemic stroke and the potential mechanism. After screening out miRNA-324-5p, its level in peripheral blood of stroke patients and in vitro oxygen-glucose deprivation (OGD)-induced primary rat neurons was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Regulatory effects of miRNA-324-5p on viability, and apoptosis of OGD-induced neurons were evaluated by CCK-8 and Annexin V fluorescei...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Systematically transplanted human gingiva-derived mesenchymal stem cells regulate lipid metabolism and inflammation in hyperlipidemic mice with periodontitis.
Authors: Liu X, Wang Z, Song W, Sun W, Hong R, Pothukuchi A, Xu Q Abstract Gingiva-derived mesenchymal stem cells (GMSCs) have been the focus of extensive research due to their numerous distinct properties, including their homing to injury sites and their contribution to tissue regeneration. However, the role of transplanted GMSCs in the regulation of lipid metabolism and inflammation in hyperlipidemic mice with periodontitis has not been demonstrated. In the present study, apolipoprotein E-deficient (ApoE-/-) mice were used to establish a hyperlipidemia model with periodontitis and divided into two groups: Group B...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Sanjin tablet combined with antibiotics for treating patients with acute lower urinary tract infections: A meta-analysis and GRADE evidence profile.
Authors: Lyu J, Xie Y, Sun M, Zhang C, Wang L Abstract Numerous clinical studies have evaluated the performance of Sanjin tablets (SJTs) in the treatment of acute lower urinary tract infections (ALUTIs) in China. The present meta-analysis aimed to determine the efficacy and safety of SJT combined with antibiotics for the treatment of patients with ALUTIs and to evaluate the quality of evidence. The Cochrane Library, PubMed, EMBASE, Web of Science, Chinese BioMedical Database, China National Knowledge Infrastructure, WanFang and VIP databases were searched for entries added between inception and December 2018 to ide...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

miRNA-429 suppresses osteogenic differentiation of human adipose-derived mesenchymal stem cells under oxidative stress via targeting SCD-1.
Authors: Lan C, Long L, Xie K, Liu J, Zhou L, Pan S, Liang J, Tu Z, Gao Z, Tang Y Abstract Role of microRNA-429 (miRNA-429) in osteogenic differentiation of hADMSCs was elucidated to explore the potential mechanism. Serum level of miRNA-429 in osteoporosis patients and controls was determined by quantitative real-time polymerase chain reaction (qRT-PCR). After H2O2 induction in hADMSCs, cell viability and reactive oxygen species (ROS) level were determined by cell-counting kit (CCK-8) assay and flow cytometry, respectively. Alkaline phosphatase (ALP) activity in H2O2-induced hADMSCs was also detected. The binding c...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

A novel approach regarding the anti-aging of facial skin through collagen reorganization.
Authors: Sifaki M, Calina D, Docea AO, Tsioumas S, Katsarou MS, Papadogiorgaki S, Fragkiadaki P, Branisteanu DE, Kouskoukis K, Tsiaoussis J, Spandidos DA Abstract The needle shaping technique can be used to perform subcutaneous microtransplants, enabling the 'lifting' of the skin. This prospective cohort study aimed to examine the effects of needle shaping on facial skin tone, volume and histological structure. A total of 54 women underwent the needle shaping procedure performed by inserting a tiny acupuncture needle combined with mixed electrical currents. The overall treatment was completed within 4 sessions of 2...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

STAT3 speeds up progression of osteoarthritis through NF- κB signaling pathway.
In this study, we constructed a number of regulator-mediated OA dysfunction modules, and carried out in-depth analysis in order to examine the disease development process. Differential expression analysis, co-expression analysis and enrichment analysis were combined to screen genes related to disease progression. Subsequently, key regulatory factors in the process of OA were identified based on the pivotal regulators that may manipulate important parts of the module subnetwork. A total of 16 OA dysfunction modules were obtained, involving the aggregation of 3,239 module genes. Then, enrichment analysis showed that module g...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Angiotensin type 1 receptor regulates yes-associated protein in vascular endothelial cells.
Authors: Wang X, Zhang H, Ge Y, Liu J, Rong D, Cao L, He Y, Sun G, Jia S, Guo W Abstract Aortic dissection (AD) is one of the most lethal cardiovascular diseases. Endothelial cell (EC) dysfunction serves an important role in AD progression. Angiotensin II (Ang II) is a key effector in cardiovascular disease development that acts through binding to angiotensin type 1 receptor (AT1R). Yes-associated protein (YAP) is well-known as a key mediator of cell proliferation and apoptosis. To determine whether AT1R and YAP influence EC proliferation or injury, human aortic endothelial cells were cultured under different cultu...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Increased expression of CD81 is associated with poor prognosis of prostate cancer and increases the progression of prostate cancer cells in vitro.
Authors: Zhang Y, Qian H, Xu A, Yang G Abstract CD81, a member of the tetraspanin family, has been revealed to be upregulated and associated with prognosis in several types of cancer; however, this relationship has not been explored in prostate cancer. The present study aimed to investigate the prognostic significance and functional role of CD81 in prostate cancer. The expression of CD81 in prostate cancer tissues and cell lines was evaluated using qRT-PCR analysis. Kaplan-Meier survival analysis and Cox regression analysis were conducted to explore the prognostic significance of CD81. Cell experiments were used to...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Hydrogen sulfide modulates high glucose-induced NLRP3 inflammasome activation in 3T3-L1 adipocytes.
In conclusion, HG may increase and exogenous H2S may inhibit HG-induced NLRP3 inflammasome activation in adipocytes. PMID: 31885713 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Administration effects of single-dose GnRH agonist for luteal support in females undertaking IVF/ICSI cycles: A meta-analysis of randomized controlled trials.
Authors: Song M, Liu C, Hu R, Wang F, Huo Z Abstract The aim of the present meta-analysis was to evaluate the effects of the addition of single-dose gonadotropin-releasing hormone agonist (GnRHa) for luteal support on pregnancy outcomes in females partaking in in vitro fertilization or intracytoplasmic sperm injection cycles. In total, the studies were hand-searched from six electronic databases to compare the pregnancy outcomes between single-dose GnRHa administered as luteal phase support (GnRHa group) and regular luteal support (control group). In the GnRHa group, single-dose GnRH agonist were administered at 5/...
Source: Experimental and Therapeutic Medicine - December 31, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Clinical characteristics and association analysis of persistent low-level HBsAg expression in a physical examination population with HBV infection.
Authors: Dai Y, Che F, Jiang X, Cui D, Zhou H, Xu X, Sun C, Cheng J Abstract Certain patients with hepatitis B virus (HBV) infection present with persistently low levels of serum hepatitis B surface antigen (HBsAg) and have been indicated to have low rates of HBV nucleic acid replication. To explore the serological and molecular epidemiological characteristics of HBV population with low-level HBsAg in the present study, associated serum markers and virologic genotype detection were performed accordingly. Determination of HBV markers was performed using a chemiluminescence immunoassay from which 2,544 out of 45,256 ...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Bisphenol A-induced oxidative damage in the hepatic and cardiac tissues of rats: The modulatory role of sesame lignans.
Authors: Eweda SM, Newairy ASA, Abdou HM, Gaber AS Abstract Bisphenol A (BPA) is an environmental pollutant that is widely produced throughout the world. It is primarily used in the manufacture of polycarbonate plastics, epoxy resins, paints and dental materials. BPA has been reported to promote hepatotoxicity and cardiotoxicity. The antioxidant activity of sesame lignans is well established. The current study assessed the protective efficiency of sesame lignans against BPA-induced hepatotoxicity and cardiotoxicity. Rats were divided into 4 groups: A control group, a BPA-treated group, a sesame lignans-treated grou...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Pterostilbene reduces endothelial cell injury in vascular arterial walls by regulating the Nrf2-mediated AMPK/STAT3 pathway in an atherosclerosis rat model.
In conclusion, these data suggest that Pts can protect endothelial cells in the vascular arterial walls against atherosclerosis-induced injury through regulation of the Nrf2-mediated AMPK/STAT3 pathway. PMID: 31853271 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

MicroRNA-30d-5p promotes ovarian granulosa cell apoptosis by targeting Smad2.
Authors: Yu M, Liu J Abstract Polycystic ovarian syndrome (PCOS) is one of the leading causes of female infertility. MicroRNA-30d-5p (miR-30d-5p) has been reported to be significantly increased during follicle stimulating hormone (FSH)-mediated progesterone secretion of cultured granulosa cells. However, its role in the proliferation and apoptosis of ovarian granulosa cells is unclear. The present study aimed to investigate the role of miR-30d-5p in the proliferation and apoptosis of ovarian granulosa cells. Bioinformatic analysis and dual-luciferase reporter assay were used to predict and confirm the direct target...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Correlation of cathepsin S with coronary stenosis degree, carotid thickness, blood pressure, glucose and lipid metabolism and vascular endothelial function in atherosclerosis.
In conclusion, as the serum cathepsin S level is elevated, the coronary stenosis is aggravated, the carotid thickness and blood pressure are increased, and the glucose and lipid metabolism, as well as vascular endothelial function are significantly abnormal. PMID: 31853273 [PubMed] (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Increase in liver γδ T cells with concurrent augmentation of IFN-β production during the early stages of a mouse model of acute experimental hepatitis B virus infection.
Increase in liver γδ T cells with concurrent augmentation of IFN-β production during the early stages of a mouse model of acute experimental hepatitis B virus infection. Exp Ther Med. 2020 Jan;19(1):67-78 Authors: Chang L, Wang L, Ling N, Peng H, Chen M Abstract The role of γδ T cells in acute hepatitis B virus (HBV) infection remains unclear. For the present study, a mouse model of acute HBV infection was constructed using hydrodynamic injection-based transfection of an HBV DNA plasmid (pHBV). Subsequent changes in the percentages of γδ T cells, expression of a...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

miR-190b promotes colorectal cancer progression through targeting forkhead box protein P2.
Authors: Zhao Q, Liu C, Cui Q, Luan X, Wang Q, Zhou C Abstract microRNA-190b (miR-190b) is abnormally expressed in multiple types of cancer, however, its role in colorectal cancer (CRC) is largely unknown. In the present study, it was demonstrated that miR-190b expression was upregulated in CRC cell lines compared with the normal epithelial colon cell line. Knockdown of miR-190b decreased proliferation, colony formation and invasion, and increased apoptosis of CRC cells. Furthermore, forkhead box protein P2 (FOXP2) was predicted as a target of miR-190b and further validated by luciferase activity reporter assay and...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Fructus Viticis methanolic extract attenuates trigeminal hyperalgesia in migraine by regulating injury signal transmission.
Authors: Wen W, Chen H, Fu K, Wei J, Qin L, Pan T, Xu S Abstract Migraine, characterized by hyperalgesia of the trigeminovascular system, is a severe condition that leads to severe reductions in the quality of life. Upon external stimulation, the levels of various neurotransmitters, including aspartic acid (Asp), glutamic acid (Glu), γ-amino butyric acid (GABA), norepinephrine (NE) and 5-hydroxytryptamine (5-HT), are significantly altered; this directly or indirectly promotes trigeminal hypersensitivity. Fructus Viticis is a Traditional Chinese Medicine with analgesic properties to provide efficient relief of...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research

Transgastric endoscopic gallbladder polypectomy and cholecystolithiasis: A case report.
Authors: Li Y, Han S Abstract As the most common digestive-system disease, cholelithiasis and gallbladder polyps have a high incidence. The most common treatment is laparoscopic cholecystectomy, but there are numerous drawbacks, including stump syndrome. In the present study, a novel treatment, namely transgastric endoscopic gallbladder polypectomy and cholecystolithiasis, was applied. To the best of our knowledge, the present study is the first to report on this application, which can potentially avoid open surgery and associated scars and allows for rapid recovery after surgery, and may therefore be worthy of fur...
Source: Experimental and Therapeutic Medicine - December 21, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research