Experimental and Therapeutic Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence ‑based practice
Exp Ther Med. 2024 Feb 28;27(4):173. doi: 10.3892/etm.2024.12461. eCollection 2024 Apr.ABSTRACTThe dose-dependent pharmacological response to dapagliflozin in patients with type 2 diabetes mellitus (T2DM) with regard to weight loss remain unknown. The aim of the present study was to investigate the effects of dapagliflozin on weight loss in patients with T2DM. A total of 8,545 patients with T2DM from 24 randomized controlled trials reported in the literature were selected for inclusion in the study. Data from these trials were analyzed using maximal effect (Emax) models with nonlinear mixed effects modeling; the evaluation...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yan Han Ya-Feng Li Chao-Wei Ye Yao-Yang Gu Xiao Chen Qian Gu Qiang-Qiang Xu Xian-Ming Wang Su-Mei He Dong-Dong Wang Source Type: research

Antibiotic administration aggravates asthma by disrupting gut microbiota and the intestinal mucosal barrier in an asthma mouse model
Exp Ther Med. 2024 Feb 21;27(4):157. doi: 10.3892/etm.2024.12445. eCollection 2024 Apr.ABSTRACTIn humans, gut microbiota can determine the health status. The regulatory mechanisms of the gut microbiota in asthma must be elucidated. Although antibiotics (ABXs) can clear infections, they markedly alter the composition and abundance of gut microbiota. The present study used ABX-treated mice to examine the time-dependent effects of ABX administration on the gut microbiota and intestinal mucosal barrier. The mouse asthma model was established using ovalbumin (OVA) and gavaged with an ABX cocktail for different durations (1 or 2...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Cheng-Ling Xu Cui Wang Gao-Bin Li Tong Zhao Rui-Ling Zhou Jing Chen Source Type: research

Meta ‑analysis of the efficacy of venetoclax and azacitidine combination therapy and azacitidine monotherapy for treating acute myeloid leukemia
In conclusion, the combination of venetoclax and azacitidine was more effective than azacitidine alone, and had a good clinical application value in the treatment of AML. Although some adverse reactions occurred in response to the combination therapy, they did not significantly affect the prognosis of AML. To better evaluate the efficacy and safety of this treatment regimen, multicenter clinical studies with larger sample sizes are required.PMID:38476897 | PMC:PMC10928973 | DOI:10.3892/etm.2024.12452 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yuqin Xie Xueqin Wei Weiwei Wang Changsheng Liao Pengfei Han Yanhui Yu Source Type: research

CHL1 inhibits cell proliferation, migration and invasion by regulating the NF ‑κB signaling pathway in colorectal cancer
Exp Ther Med. 2024 Feb 26;27(4):165. doi: 10.3892/etm.2024.12454. eCollection 2024 Apr.ABSTRACTCell adhesion molecule close homolog of L1 (CHL1) is implicated in tumorigenesis of various malignancies. However, its role and underlying molecular mechanisms in colorectal cancer (CRC) remain unclear. The present study aimed to evaluate the specific biological functions and mechanisms of CHL1, in order to provide a theoretical basis for the use of CHL1 as a biological target in CRC. CHL1 expression was originally determined in CRC cell lines. Subsequently, CHL1 overexpression was induced by plasmid transfection in HT29 and SW48...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Ming Bao Shenglong Li Yu Zhu Xiaoyu Dong Ran Wang Fangyan Jing Source Type: research

Role of microRNAs in cognitive decline related to COVID ‑19 (Review)
Exp Ther Med. 2024 Feb 14;27(4):139. doi: 10.3892/etm.2024.12427. eCollection 2024 Apr.ABSTRACTThe likelihood and severity of cognitive decline related to coronavirus disease 2019 (COVID-19) have been shown to be reflected by the severity of the infection and concomitant alterations in specific biomarkers. The present review discusses the role of microRNAs (miRNAs/miRs) as biomarkers in COVID-19 and the potential molecular mechanisms of cognitive dysfunction related to COVID-19. A systematic search of published articles was carried out from January 31, 2000 to December 31, 2022 using the PubMed, ProQuest, Science Direct an...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Anastasia Bougea Vasiliki Epameinondas Georgakopoulou Ioannis G Lempesis George Fotakopoulos Petros Papalexis Pagona Sklapani Nikolaos Trakas Demetrios A Spandidos Efthalia Angelopoulou Source Type: research

Comparison of diagnostic performance of X ‑ray, CT and MRI in patients with surgically confirmed subtle Lisfranc injuries
In conclusion, non-weight-bearing X-rays had poor diagnostic accuracy for subtle Lisfranc injuries and their subtypes. CT was superior to X-rays and MRI in diagnosing first-ray injuries. Although not significantly different from CT in terms of overall diagnosis, MRI was superior to X-ray and CT in diagnosing second and cuneiform-ray injuries.PMID:38476900 | PMC:PMC10928826 | DOI:10.3892/etm.2024.12462 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Lubo Tang Wen Zhou Lu Bai Chenxi Wu Changyue Xiong Yuxin Yan Sumeng Chen Source Type: research

[Retracted] MicroRNA ‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1
Exp Ther Med. 2024 Feb 26;27(4):163. doi: 10.3892/etm.2024.12451. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2019.8348.].PMID:38476901 | PMC:PMC10928988 | DOI:10.3892/etm.2024.12451 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Juan Feng Tingfeng Wang Source Type: research

Predominant control of PDGF/PDGF receptor signaling in the migration and proliferation of human adipose ‑derived stem cells under culture conditions with a combination of growth factors
Exp Ther Med. 2024 Feb 21;27(4):156. doi: 10.3892/etm.2024.12444. eCollection 2024 Apr.ABSTRACTHuman adipose-derived stem cells (hASCs) play important roles in regenerative medicine and tissue engineering. However, their clinical applications are limited because of their instability during cell culture. Platelet lysates (PLTs) contain large amounts of growth factors that are useful for manufacturing cellular products. Platelet-derived growth factor (PDGF) is a major growth factor in PLTs and a potent mitogen in hASCs. To optimize growth conditions, the effects of a combination of growth factors on the promotion of hASC pro...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Zhongxin Sun Michika Fukui Shigeru Taketani Ayako Kako Sakurako Kunieda Natsuko Kakudo Source Type: research

Risk factors and predictive model for mortality in patients undergoing allogeneic hematopoietic stem cell transplantation admitted to the intensive care unit
Exp Ther Med. 2024 Feb 27;27(4):168. doi: 10.3892/etm.2024.12457. eCollection 2024 Apr.ABSTRACTHematological malignant tumors represent a group of major diseases carrying a substantial risk to the lives of affected patients. Risk factors for mortality in critically ill patients have garnered substantial attention in recent research endeavors. The present research aimed to identify factors predicting intensive care unit (ICU) mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Furthermore, the present study analyzed and compared the mortality rate between patients undergoing hapl...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Peihua Wu Wenxuan Huo Huiying Zhao Jie Lv Shan Lv Youzhong An Source Type: research

Reproductive outcomes following copper ‑containing intrauterine device after hysteroscopic lysis for intrauterine adhesions
Exp Ther Med. 2024 Feb 29;27(4):175. doi: 10.3892/etm.2024.12463. eCollection 2024 Apr.ABSTRACTThe present study aimed to investigate the reproductive outcomes of copper-containing intrauterine devices (IUDs) after hysteroscopic lysis in patients with mild to severe intrauterine adhesions (IUAs), according to the American Fertility Society (AFS) classification. Therefore, a prospective randomized controlled study was conducted at the Affiliated Jinhua Hospital of Wenzhou Medical University (Jinhua, China). A total of 173 women with IUAs were initially recruited between January 2020 and June 2021 and were then randomized to...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Pan Xu Heng Xu Qiaoqiao Lu Shanshan Ling E Hu Ying Song Jie Liu Bixia Yi Source Type: research

Enhancer of zeste homolog 2 facilitates phenotypic transition of vascular smooth muscle cells leading to aortic aneurysm/dissection
In conclusion, the present study identified a previously unrecognized EZH2-ITGB3 regulatory axis and thus provides novel mechanistic insights into the pathophysiological function of EZH2. EZH2 may thus serve as a potential target for the management of TAAs.PMID:38476905 | PMC:PMC10928840 | DOI:10.3892/etm.2024.12433 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Shishan Xue Shuai Leng Fengquan Zhang Zhiqiao Dang Guohai Su Wenqian Yu Source Type: research

Unilateral percutaneous vertebroplasty in osteoporotic vertebral compression fractures: A clinical efficacy evaluation
In conclusion, the unilateral PVP method is safe and efficient for the management of osteoporotic vertebral compression fractures.PMID:38476906 | PMC:PMC10928977 | DOI:10.3892/etm.2024.12439 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Dongdong Shi Xiaoling Li Fang Huang Gejin Wei Zhoudan Lin Source Type: research

PJ ‑001, a small‑molecule proteolysis‑targeting chimera, ameliorates atopic dermatitis‑like inflammation in mice by inhibiting the JAK2/STAT3 pathway and repairing the skin barrier
In conclusion, PJ-001 could be considered a potential therapeutic option for AD.PMID:38476907 | PMC:PMC10928824 | DOI:10.3892/etm.2024.12464 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Pei Lin Zhendong Chen Yinying Lu Hongyu Shi Jun Lin Source Type: research

[Retracted] Overexpression of indoleamine 2, 3 ‑dioxygenase contributes to the repair of human airway epithelial cells inhibited by dexamethasone via affecting the MAPK/ERK signaling pathway
Exp Ther Med. 2024 Feb 19;27(4):144. doi: 10.3892/etm.2024.12432. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2018.6163.].PMID:38476908 | PMC:PMC10928849 | DOI:10.3892/etm.2024.12432 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Shanshan Jia Pin Guo Xiangjin Ge Huanhuan Wu Junhua Lu Xiaofang Fan Source Type: research

Tumor immunity: A brief overview of tumor ‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)
In conclusion, the present review summarized the biological classification of TILs and the mechanisms of their involvement in the regulation of the immune microenvironment, and subsequently analyzed the development of tumor immunotherapy for TILs. Collectively, the present review provides ideas for the current treatment dilemma of gynecological tumor immune checkpoints, such as adverse reactions, safety, personal specificity and efficacy.PMID:38476909 | PMC:PMC10928974 | DOI:10.3892/etm.2024.12453 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Zi-Tao Wang Zhi-Min Deng Fang-Fang Dai Meng-Qin Yuan Shi-Yi Liu Bing-Shu Li Yan-Xiang Cheng Source Type: research