Immune profile of patients ‑a new approach in management of sepsis and septic shock?
Exp Ther Med. 2024 Mar 15;27(5):203. doi: 10.3892/etm.2024.12489. eCollection 2024 May.ABSTRACTThe present study was a prospective observational single center study, enrolling 102 patients with sepsis, admitted in the Intensive Care Unit of the County Emergency Clinical Hospital in Târgu Mureș (Mureș, Romania). The main goal of the present study was to compare the changes of the following parameters on day 1 compared with day 5, in sepsis compared with septic shock, as well as in survivors compared with non-survivors: Cell blood count parameters, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic inflam...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Anca Bac ârea Oana Coman Vladimir Constantin Bac ârea Anca Meda V ăsieşiu Irina S ăplăcan Raluca Śtefania Fodor Bianca Liana Grigorescu Source Type: research

Airway basal cell ‑derived exosomes suppress epithelial‑mesenchymal transition of lung cells by inhibiting the expression of ANO1
In conclusion, airway basal cell-derived exosomes suppressed the EMT of lung cells via the downregulation of ANO1. These exosomes represent a potential therapeutic option for patients with IPF.PMID:38590572 | PMC:PMC11000454 | DOI:10.3892/etm.2024.12507 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Xiaohua Gu Zeyu Liu Shan Shan Tao Ren Shaoyang Wang Source Type: research

Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta ‑analysis
Exp Ther Med. 2024 Mar 20;27(5):215. doi: 10.3892/etm.2024.12503. eCollection 2024 May.ABSTRACTIntracranial cavernous malformations (CMs) are vascular lesions with a high bleeding rate. At present, the debate regarding their treatment is still ongoing. The present systematic review and meta-analysis aimed to evaluate the safety of surgery or radiosurgery (SRS) for the management of CMs and to determine their potential outcomes compared with conservative treatment. The present systematic review and meta-analysis investigated the relative articles involving the management of intracranial CMs, namely their natural history (co...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: George Fotakopoulos Vasiliki Epameinondas Georgakopoulou Petros Papalexis Demetrios A Spandidos Nikolaos Trakas Pagona Sklapani Kostas N Fountas Source Type: research

Endothoracic lymphatic plexus ‑hemiazygos vein anastomosis for chylothorax complicated with hepatocellular carcinoma: A case report
In conclusion, LVA could be appropriate to treat chylothorax when TDL is ineffective as a remedial or even prophylactic intervention.PMID:38590574 | PMC:PMC11000049 | DOI:10.3892/etm.2024.12495 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yi Jiang Cong Liu Yingtong Huang Naiquan Mao Xiaoming Liao Source Type: research

Clinical presentation of severe COVID ‑19 with heart failure: A single‑center retrospective study
In conclusion, HF combined with COVID-19, treatment and prognosis are getting worse. Enhancing preparedness for future COVID-19 and other similar pandemics necessitates the comprehension of this to refine care provided to patients with HF (registration no. THH-IPR-20221101 on 01 November 2022).PMID:38590575 | PMC:PMC11000051 | DOI:10.3892/etm.2024.12481 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Xinling Liu Tingting Liu Rong Wan Source Type: research

Treatment of rectal anastomotic atresia with transurethral prostate resection instrumentation: A report of three cases
Exp Ther Med. 2024 Mar 15;27(5):202. doi: 10.3892/etm.2024.12491. eCollection 2024 May.ABSTRACTDixon surgery for rectal cancer can lead to severe intestinal narrowing and blockage that is difficult to treat with open surgery or colonoscopy. The aim of the present study was to develop a minimally invasive approach for treating rectal anastomotic atresia based on three cases that were managed with transurethral prostate resection instrumentation. Preoperative imaging determined the distance from the anastomotic closure to the anal margin, the length of the anastomotic closure and the degree of proximal intestinal dilation fo...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Zhentao Hu Yujie Qin Xiaoyi Wei Jun Qian Song Tu Jiaxi Yao Source Type: research

Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age ‑related macular degeneration
Exp Ther Med. 2024 Mar 20;27(5):214. doi: 10.3892/etm.2024.12501. eCollection 2024 May.ABSTRACTThe present study aimed to examine the optical coherence tomography angiography (OCTA) parameters associated with macular neovascularization (MNV) in patients diagnosed with neovascular age-related macular degeneration (nAMD) and treated with either intravitreal conbercept (IVC) or ranibizumab (IVR). It enrolled 39 nAMD patients presenting with MNV, including 23 in the IVC group and 16 in the IVR group. All participants were treatment-naïve with intravitreal therapy and they underwent treatment following a '3+PRN' regimen. The M...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Jing Li Zhufang Yang Xueying Li Di Li Jin Yang Meijia Dang Source Type: research

Eukaryotic translation initiation factor < em > EIF4G1 < /em > p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor
In conclusion, the results from the present study suggested that EIF4G1 may be responsible for the hereditary PD with 'antecedent ET' reported in the family assessed.PMID:38590578 | PMC:PMC11000071 | DOI:10.3892/etm.2024.12494 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Rui-Han Liu Xiang-Yu Xiao Lei Yao Yuan-Yuan Jia Jia Guo Xing-Chen Wang Yu Kong Qing-Xia Kong Source Type: research

RFC3 drives the proliferation, migration, invasion and angiogenesis of colorectal cancer cells by binding KIF14
In conclusion, RFC3 might interact with KIF14 to function as a contributor to the malignant development of CRC.PMID:38590579 | PMC:PMC11000453 | DOI:10.3892/etm.2024.12510 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Rong Yu Xinxin Wu Fang Qian Qian Yang Source Type: research

Role of crosstalk between synovial cells and chondrocytes in osteoarthritis (Review)
Exp Ther Med. 2024 Mar 15;27(5):201. doi: 10.3892/etm.2024.12490. eCollection 2024 May.ABSTRACTOsteoarthritis (OA) is a low-grade, nonspecific inflammatory disease that affects the entire joint. This condition is characterized by synovitis, cartilage erosion, subchondral bone defects, and subpatellar fat pad damage. There is mounting evidence demonstrating the significance of crosstalk between synovitis and cartilage destruction in the development of OA. To comprehensively explore the phenotypic alterations of synovitis and cartilage destruction, it is important to elucidate the crosstalk mechanisms between chondrocytes an...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Baisen Chen Yuyu Sun Guanhua Xu Jiawei Jiang Wenhao Zhang Chunshuai Wu Pengfei Xue Zhiming Cui Source Type: research

Microbiota analysis in individuals with type two diabetes mellitus and end ‑stage renal disease: A pilot study
In conclusion, the present pilot study focused on gut microbiome alterations in T2DM and ESRD. Understanding the relationship between dysbiosis and CKD may identify new areas of research and therapeutic interventions aimed at modulating the gut microbiota to improve the health and outcomes of individuals with CKD and ESRD.PMID:38590581 | PMC:PMC11000444 | DOI:10.3892/etm.2024.12500 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Maria Trandafir Gratiela Gradisteanu Pircalabioru Octavian Savu Source Type: research

The parallel lives of pandemics: COVID ‑19 and obesity
Exp Ther Med. 2024 Mar 6;27(5):184. doi: 10.3892/etm.2024.12472. eCollection 2024 May.ABSTRACTThe present article discusses the interconnectedness of coronavirus disease 2019 (COVID-19) and obesity as global health crises. The similarities between the two conditions are highlighted; these include shared risk factors and comorbidities, and the impact of obesity on the immune system. The present article also mentions the challenges faced in combating both pandemics, including misinformation and prejudice against obesity. It discusses the development of therapeutic medications and vaccines for COVID-19 and the potential of in...
Source: Experimental and Therapeutic Medicine - March 29, 2024 Category: General Medicine Authors: Vasiliki Epameinondas Georgakopoulou Ioannis G Lempesis Demetrios A Spandidos Source Type: research