Experimental and Therapeutic Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
Sex differences in diabetes ‑induced hepatic and renal damage
In conclusion, the present study characterized the features of liver and kidney damage in db/db mice and indicated that sex differences should be taken into account in experiments using female and male experimental animals. Furthermore, sex differences should be taken into account in the selection of drug interventions in experiments and in clinical drug therapy.PMID:38476888 | PMC:PMC10928993 | DOI:10.3892/etm.2024.12436 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Linghuan Gao Xindi Wang Lei Guo Wenli Zhang Gengyin Wang Shuying Han Yuxin Zhang Source Type: research
Mitochondrial calcium uniporter promotes mitophagy by regulating the PINK1/Parkin pathway in caerulein ‑treated pancreatic ductal epithelial cells < em > in < /em > < em > vitro < /em >
In conclusion, an activated MCU may promote mitophagy by regulating the PINK1/Parkin pathway in PDECs in AP.PMID:38476889 | PMC:PMC10928816 | DOI:10.3892/etm.2024.12435 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yu Lei Hui-Ying Yang Nuo Meng Ying-Ying Qin Meng-Tao Xu Xue-Lian Xiang Li Liu Guo-Du Tang Source Type: research
Erratum: [Corrigendum] miR ‑216a‑5p acts as an oncogene in renal cell carcinoma
Exp Ther Med. 2024 Feb 21;27(4):155. doi: 10.3892/etm.2024.12443. eCollection 2024 Apr.ABSTRACT[This corrects the article DOI: 10.3892/etm.2018.5881.].PMID:38476890 | PMC:PMC10928975 | DOI:10.3892/etm.2024.12443 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Peijie Chen Jing Quan Lu Jin Canbin Lin Weijie Xu Jinling Xu Xin Guan Zebo Chen Liangchao Ni Shangqi Yang Yun Chen Yongqing Lai Source Type: research
Predictive nomogram models for atrial fibrillation in COPD patients: A comprehensive analysis of risk factors and prognosis
Exp Ther Med. 2024 Feb 28;27(4):171. doi: 10.3892/etm.2024.12459. eCollection 2024 Apr.ABSTRACTThe aim of the present study was to identify the independent risk factors and prognostic indicators for atrial fibrillation (AF) in patients with chronic obstructive pulmonary disease (COPD) and to develop predictive nomogram models. This retrospective study included a total of 286 patients with COPD who were admitted to the Second Affiliated Hospital of Guilin Medical College between January 2020 and May 2022. The average age of the patients was 77.11±8.67 years. Based on the presence or absence of AF, the patients were divided...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Tao Huang Xingjie Huang Xueying Cui Qinghua Dong Source Type: research
Biochanin A inhibits endothelial dysfunction induced by IL ‑6‑stimulated endothelial microparticles in Perthes disease via the NFκB pathway
Exp Ther Med. 2024 Feb 13;27(4):137. doi: 10.3892/etm.2024.12425. eCollection 2024 Apr.ABSTRACTEndothelial dysfunction caused by the stimulation of endothelial microparticles (EMPs) by the inflammatory factor IL-6 is one of the pathogenic pathways associated with Perthes disease. The natural active product biochanin A (BCA) has an anti-inflammatory effect; however, whether it can alleviate endothelial dysfunction in Perthes disease is not known. The present in vitro experiments on human umbilical vein endothelial cells showed that 0-100 pg/ml IL-6-EMPs could induce endothelial dysfunction in a concentration-dependent manne...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Jianhong Liu Chengsen Lin Boxiang Li Qian Huang Xianxiang Chen Shengping Tang Xiaolin Luo Rongbin Lu Yun Liu Shijie Liao Xiaofei Ding Source Type: research
Transcriptomic analysis of lipoteichoic acid ‑treated undifferentiated and neutrophil‑like differentiated HL‑60 cells
Exp Ther Med. 2024 Feb 22;27(4):158. doi: 10.3892/etm.2024.12446. eCollection 2024 Apr.ABSTRACTToll-like receptor 2 (TLR2) is an important sensor for innate immune cells, including neutrophils, for the recognition of pathogen infection. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is a TLR2 ligand. LTA-induced TLR2 signaling pathways are well established in neutrophils. However, experimental studies regarding transcriptional regulation and the molecular mechanisms in primary human neutrophils are limited due to their short lifespan. The promyelocytic leukemia cell line, HL-60, can differentiate...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Kuan-Ting Liu I-Jeng Yeh Ya-Ling Hsu Meng-Chi Yen Source Type: research
Effect of tofacitinib on the phenotype and activity of Caco ‑2 cells in a model of inflammatory bowel disease
In conclusion, the inhibitory effects of tofacitinib on oxidative stress, as well as its anti-apoptotic and regenerative effects, provide important information regarding the positive effect of tofacitinib on Caco-2 cells, and therefore constitute potential information about the beneficial effect of the evaluated drug in UC.PMID:38476894 | PMC:PMC10928998 | DOI:10.3892/etm.2024.12440 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Estera Skudrzyk Łukasz Bułdak Grzegorz Machnik Bogus ław Okopień Source Type: research
Effects of dapagliflozin on body weight in patients with type 2 diabetes mellitus: Evidence ‑based practice
Exp Ther Med. 2024 Feb 28;27(4):173. doi: 10.3892/etm.2024.12461. eCollection 2024 Apr.ABSTRACTThe dose-dependent pharmacological response to dapagliflozin in patients with type 2 diabetes mellitus (T2DM) with regard to weight loss remain unknown. The aim of the present study was to investigate the effects of dapagliflozin on weight loss in patients with T2DM. A total of 8,545 patients with T2DM from 24 randomized controlled trials reported in the literature were selected for inclusion in the study. Data from these trials were analyzed using maximal effect (Emax) models with nonlinear mixed effects modeling; the evaluation...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yan Han Ya-Feng Li Chao-Wei Ye Yao-Yang Gu Xiao Chen Qian Gu Qiang-Qiang Xu Xian-Ming Wang Su-Mei He Dong-Dong Wang Source Type: research
Antibiotic administration aggravates asthma by disrupting gut microbiota and the intestinal mucosal barrier in an asthma mouse model
Exp Ther Med. 2024 Feb 21;27(4):157. doi: 10.3892/etm.2024.12445. eCollection 2024 Apr.ABSTRACTIn humans, gut microbiota can determine the health status. The regulatory mechanisms of the gut microbiota in asthma must be elucidated. Although antibiotics (ABXs) can clear infections, they markedly alter the composition and abundance of gut microbiota. The present study used ABX-treated mice to examine the time-dependent effects of ABX administration on the gut microbiota and intestinal mucosal barrier. The mouse asthma model was established using ovalbumin (OVA) and gavaged with an ABX cocktail for different durations (1 or 2...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Cheng-Ling Xu Cui Wang Gao-Bin Li Tong Zhao Rui-Ling Zhou Jing Chen Source Type: research
Meta ‑analysis of the efficacy of venetoclax and azacitidine combination therapy and azacitidine monotherapy for treating acute myeloid leukemia
In conclusion, the combination of venetoclax and azacitidine was more effective than azacitidine alone, and had a good clinical application value in the treatment of AML. Although some adverse reactions occurred in response to the combination therapy, they did not significantly affect the prognosis of AML. To better evaluate the efficacy and safety of this treatment regimen, multicenter clinical studies with larger sample sizes are required.PMID:38476897 | PMC:PMC10928973 | DOI:10.3892/etm.2024.12452 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yuqin Xie Xueqin Wei Weiwei Wang Changsheng Liao Pengfei Han Yanhui Yu Source Type: research
CHL1 inhibits cell proliferation, migration and invasion by regulating the NF ‑κB signaling pathway in colorectal cancer
Exp Ther Med. 2024 Feb 26;27(4):165. doi: 10.3892/etm.2024.12454. eCollection 2024 Apr.ABSTRACTCell adhesion molecule close homolog of L1 (CHL1) is implicated in tumorigenesis of various malignancies. However, its role and underlying molecular mechanisms in colorectal cancer (CRC) remain unclear. The present study aimed to evaluate the specific biological functions and mechanisms of CHL1, in order to provide a theoretical basis for the use of CHL1 as a biological target in CRC. CHL1 expression was originally determined in CRC cell lines. Subsequently, CHL1 overexpression was induced by plasmid transfection in HT29 and SW48...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Ming Bao Shenglong Li Yu Zhu Xiaoyu Dong Ran Wang Fangyan Jing Source Type: research
Role of microRNAs in cognitive decline related to COVID ‑19 (Review)
Exp Ther Med. 2024 Feb 14;27(4):139. doi: 10.3892/etm.2024.12427. eCollection 2024 Apr.ABSTRACTThe likelihood and severity of cognitive decline related to coronavirus disease 2019 (COVID-19) have been shown to be reflected by the severity of the infection and concomitant alterations in specific biomarkers. The present review discusses the role of microRNAs (miRNAs/miRs) as biomarkers in COVID-19 and the potential molecular mechanisms of cognitive dysfunction related to COVID-19. A systematic search of published articles was carried out from January 31, 2000 to December 31, 2022 using the PubMed, ProQuest, Science Direct an...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Anastasia Bougea Vasiliki Epameinondas Georgakopoulou Ioannis G Lempesis George Fotakopoulos Petros Papalexis Pagona Sklapani Nikolaos Trakas Demetrios A Spandidos Efthalia Angelopoulou Source Type: research
Comparison of diagnostic performance of X ‑ray, CT and MRI in patients with surgically confirmed subtle Lisfranc injuries
In conclusion, non-weight-bearing X-rays had poor diagnostic accuracy for subtle Lisfranc injuries and their subtypes. CT was superior to X-rays and MRI in diagnosing first-ray injuries. Although not significantly different from CT in terms of overall diagnosis, MRI was superior to X-ray and CT in diagnosing second and cuneiform-ray injuries.PMID:38476900 | PMC:PMC10928826 | DOI:10.3892/etm.2024.12462 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Lubo Tang Wen Zhou Lu Bai Chenxi Wu Changyue Xiong Yuxin Yan Sumeng Chen Source Type: research
[Retracted] MicroRNA ‑873 serves a critical role in human cervical cancer proliferation and metastasis via regulating glioma‑associated oncogene homolog 1
Exp Ther Med. 2024 Feb 26;27(4):163. doi: 10.3892/etm.2024.12451. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2019.8348.].PMID:38476901 | PMC:PMC10928988 | DOI:10.3892/etm.2024.12451 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Juan Feng Tingfeng Wang Source Type: research
Predominant control of PDGF/PDGF receptor signaling in the migration and proliferation of human adipose ‑derived stem cells under culture conditions with a combination of growth factors
Exp Ther Med. 2024 Feb 21;27(4):156. doi: 10.3892/etm.2024.12444. eCollection 2024 Apr.ABSTRACTHuman adipose-derived stem cells (hASCs) play important roles in regenerative medicine and tissue engineering. However, their clinical applications are limited because of their instability during cell culture. Platelet lysates (PLTs) contain large amounts of growth factors that are useful for manufacturing cellular products. Platelet-derived growth factor (PDGF) is a major growth factor in PLTs and a potent mitogen in hASCs. To optimize growth conditions, the effects of a combination of growth factors on the promotion of hASC pro...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Zhongxin Sun Michika Fukui Shigeru Taketani Ayako Kako Sakurako Kunieda Natsuko Kakudo Source Type: research