Mitochondrial calcium uniporter promotes mitophagy by regulating the PINK1/Parkin pathway in caerulein ‑treated pancreatic ductal epithelial cells < em > in < /em >   < em > vitro < /em >
In conclusion, an activated MCU may promote mitophagy by regulating the PINK1/Parkin pathway in PDECs in AP.PMID:38476889 | PMC:PMC10928816 | DOI:10.3892/etm.2024.12435 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yu Lei Hui-Ying Yang Nuo Meng Ying-Ying Qin Meng-Tao Xu Xue-Lian Xiang Li Liu Guo-Du Tang Source Type: research

Erratum: [Corrigendum] miR ‑216a‑5p acts as an oncogene in renal cell carcinoma
Exp Ther Med. 2024 Feb 21;27(4):155. doi: 10.3892/etm.2024.12443. eCollection 2024 Apr.ABSTRACT[This corrects the article DOI: 10.3892/etm.2018.5881.].PMID:38476890 | PMC:PMC10928975 | DOI:10.3892/etm.2024.12443 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Peijie Chen Jing Quan Lu Jin Canbin Lin Weijie Xu Jinling Xu Xin Guan Zebo Chen Liangchao Ni Shangqi Yang Yun Chen Yongqing Lai Source Type: research

Predictive nomogram models for atrial fibrillation in COPD patients: A comprehensive analysis of risk factors and prognosis
Exp Ther Med. 2024 Feb 28;27(4):171. doi: 10.3892/etm.2024.12459. eCollection 2024 Apr.ABSTRACTThe aim of the present study was to identify the independent risk factors and prognostic indicators for atrial fibrillation (AF) in patients with chronic obstructive pulmonary disease (COPD) and to develop predictive nomogram models. This retrospective study included a total of 286 patients with COPD who were admitted to the Second Affiliated Hospital of Guilin Medical College between January 2020 and May 2022. The average age of the patients was 77.11±8.67 years. Based on the presence or absence of AF, the patients were divided...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Tao Huang Xingjie Huang Xueying Cui Qinghua Dong Source Type: research

Biochanin A inhibits endothelial dysfunction induced by IL ‑6‑stimulated endothelial microparticles in Perthes disease via the NFκB pathway
Exp Ther Med. 2024 Feb 13;27(4):137. doi: 10.3892/etm.2024.12425. eCollection 2024 Apr.ABSTRACTEndothelial dysfunction caused by the stimulation of endothelial microparticles (EMPs) by the inflammatory factor IL-6 is one of the pathogenic pathways associated with Perthes disease. The natural active product biochanin A (BCA) has an anti-inflammatory effect; however, whether it can alleviate endothelial dysfunction in Perthes disease is not known. The present in vitro experiments on human umbilical vein endothelial cells showed that 0-100 pg/ml IL-6-EMPs could induce endothelial dysfunction in a concentration-dependent manne...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Jianhong Liu Chengsen Lin Boxiang Li Qian Huang Xianxiang Chen Shengping Tang Xiaolin Luo Rongbin Lu Yun Liu Shijie Liao Xiaofei Ding Source Type: research

Transcriptomic analysis of lipoteichoic acid ‑treated undifferentiated and neutrophil‑like differentiated HL‑60 cells
Exp Ther Med. 2024 Feb 22;27(4):158. doi: 10.3892/etm.2024.12446. eCollection 2024 Apr.ABSTRACTToll-like receptor 2 (TLR2) is an important sensor for innate immune cells, including neutrophils, for the recognition of pathogen infection. Lipoteichoic acid (LTA), a cell wall component of gram-positive bacteria, is a TLR2 ligand. LTA-induced TLR2 signaling pathways are well established in neutrophils. However, experimental studies regarding transcriptional regulation and the molecular mechanisms in primary human neutrophils are limited due to their short lifespan. The promyelocytic leukemia cell line, HL-60, can differentiate...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Kuan-Ting Liu I-Jeng Yeh Ya-Ling Hsu Meng-Chi Yen Source Type: research