PJ ‑001, a small‑molecule proteolysis‑targeting chimera, ameliorates atopic dermatitis‑like inflammation in mice by inhibiting the JAK2/STAT3 pathway and repairing the skin barrier
In conclusion, PJ-001 could be considered a potential therapeutic option for AD.PMID:38476907 | PMC:PMC10928824 | DOI:10.3892/etm.2024.12464 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Pei Lin Zhendong Chen Yinying Lu Hongyu Shi Jun Lin Source Type: research

[Retracted] Overexpression of indoleamine 2, 3 ‑dioxygenase contributes to the repair of human airway epithelial cells inhibited by dexamethasone via affecting the MAPK/ERK signaling pathway
Exp Ther Med. 2024 Feb 19;27(4):144. doi: 10.3892/etm.2024.12432. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2018.6163.].PMID:38476908 | PMC:PMC10928849 | DOI:10.3892/etm.2024.12432 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Shanshan Jia Pin Guo Xiangjin Ge Huanhuan Wu Junhua Lu Xiaofang Fan Source Type: research

Tumor immunity: A brief overview of tumor ‑infiltrating immune cells and research advances into tumor‑infiltrating lymphocytes in gynecological malignancies (Review)
In conclusion, the present review summarized the biological classification of TILs and the mechanisms of their involvement in the regulation of the immune microenvironment, and subsequently analyzed the development of tumor immunotherapy for TILs. Collectively, the present review provides ideas for the current treatment dilemma of gynecological tumor immune checkpoints, such as adverse reactions, safety, personal specificity and efficacy.PMID:38476909 | PMC:PMC10928974 | DOI:10.3892/etm.2024.12453 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Zi-Tao Wang Zhi-Min Deng Fang-Fang Dai Meng-Qin Yuan Shi-Yi Liu Bing-Shu Li Yan-Xiang Cheng Source Type: research

Fluorofenidone attenuates renal fibrosis by inhibiting lysosomal cathepsin ‑mediated NLRP3 inflammasome activation
Exp Ther Med. 2024 Feb 15;27(4):142. doi: 10.3892/etm.2024.12430. eCollection 2024 Apr.ABSTRACTCurrently, no antifibrotic drug in clinical use can effectively treat renal fibrosis. Fluorofenidone (AKFPD), a novel pyridone agent, significantly reduces renal fibrosis by inhibiting the activation of the NOD-like receptor thermal protein domain associated protein 3 (NLRP3) inflammasome; however, the underlying mechanism of this inhibition is not fully understood. The present study aimed to reveal the molecular mechanism underlying the suppression of NLRP3 inflammasome activation by AKFPD. It investigated the effect of AKFPD on...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Linfeng Zheng Wenjuan Mei Jing Zhou Xin Wei Zhijuan Huang Xiaozhen Lin Li Zhang Wei Liu Qian Wu Jinhong Li Yan Yan Source Type: research

Comparison between minimally invasive and open transforaminal lumbar interbody fusion for the treatment of multi ‑segmental lumbar degenerative disease: A systematic evaluation and meta‑analysis
Exp Ther Med. 2024 Feb 23;27(4):162. doi: 10.3892/etm.2024.12450. eCollection 2024 Apr.ABSTRACTThe present study aimed to compare the differences between minimally invasive transforaminal lumbar fusion (MIS-TLIF) and open transforaminal lumbar fusion (TLIF) for multi-segmental lumbar degenerative disease regarding intraoperative indices and postoperative outcomes. PubMed, Web of Science, Embase, CNKI, Wanfang and VIP databases were searched for literature on MIS-TLIF and open TLIF in treating multi-segmental lumbar degenerative diseases. Of the 1,608 articles retrieved, 10 were included for final analysis. The Newcastle-Ot...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Wan-Jing Zhai Zhan-Kui Wang Hua-Lv Liu Shi-Lei Qin Peng-Fei Han Yun-Feng Xu Source Type: research

Erratum: [Corrigendum] Relationship between changes in mitochondrial function and hippocampal neuronal apoptosis after recurrent convulsion during developmental stage
Exp Ther Med. 2024 Feb 15;27(4):141. doi: 10.3892/etm.2024.12429. eCollection 2024 Apr.ABSTRACT[This corrects the article DOI: 10.3892/etm.2018.6147.].PMID:38476912 | PMC:PMC10928829 | DOI:10.3892/etm.2024.12429 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yueying Liu Jieru Chen Meifang Jin Zhenhong Li Tian Tian Lili Li Hong Ni Source Type: research

Effect of prior anticoagulation therapy on outcomes of traumatic brain injury: A systematic review and meta ‑analysis
Exp Ther Med. 2024 Feb 22;27(4):160. doi: 10.3892/etm.2024.12448. eCollection 2024 Apr.ABSTRACTAnticoagulants are commonly prescribed for multiple conditions. However, their influence on traumatic brain injury (TBI) outcomes, especially mortality, is not clear. The present study aimed to explore the effect of prior anticoagulation treatment on the outcomes of TBI. PubMed, Embase, Cochrane Central Register of Controlled Trials, Scopus and CINAHL databases were systematically searched for studies on individuals diagnosed with TBI, with a subgroup on prior anticoagulation therapy. Outcomes of interest included overall mortali...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Linghong Pan Jiayao Hu Source Type: research

Treatment opinions for dens invaginatus: A case series
Exp Ther Med. 2024 Feb 13;27(4):138. doi: 10.3892/etm.2024.12426. eCollection 2024 Apr.ABSTRACTDens invaginatus (DI) is a rare congenital dental malformation characterized by enamel or cementum folded into dentine. Such teeth are susceptible to caries, pulp infection or necrosis and periradicular lesion. The complex anatomy of this disease results in difficult treatment and a high rate of therapeutic failure. Therapeutic options, such as debriding and filling invagination, root canal treatment (RCT) and intentional replantation, vary according to the morphology and infection of the involved tooth. The present study reports...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Chengshi Wei Dong Wang Lili Shen Ping Lu Zhen Meng Rongjing Zhou Source Type: research

Epidemiological insights into seasonal, sex ‑specific and age‑related distribution of bacterial pathogens in urinary tract infections
Exp Ther Med. 2024 Feb 14;27(4):140. doi: 10.3892/etm.2024.12428. eCollection 2024 Apr.ABSTRACTUrinary tract infections (UTIs) are prevalent and recurrent bacterial infections that affect individuals worldwide, posing a significant burden on healthcare systems. The present study aimed to explore the epidemiology of UTIs, investigating the seasonal, gender-specific and age-related bacterial pathogen distribution to guide clinical diagnosis. Data were retrospectively collected from electronic medical records and laboratory reports of 926 UTIs diagnosed in Fuding Hospital (Fujian University of Traditional Chinese Medicine, Fu...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Zhi-Song Zhan Jing Shi Zu-Shun Zheng Xue-Xia Zhu Juan Chen Xin-Yi Zhou Shi-Yan Zhang Source Type: research

Clinical application of a connection device consisting of a bag valve mask and nebulizer in first aid: Two case reports
Exp Ther Med. 2024 Feb 28;27(4):172. doi: 10.3892/etm.2024.12460. eCollection 2024 Apr.ABSTRACTIn clinical practice, several emergencies may threaten the life of patients, and these emergencies can be unpredictable and challenging. During the coronavirus disease 2019 pandemic, in January 2023, a patient developed respiratory distress caused by coronavirus, but was unable to access respiratory support due to shortages of medical resources, intensive care unit beds and ventilators. The medical staff quickly created a portable high-flow atomized oxygen therapy apparatus consisting of a simple breathing bag connected to a nebu...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Ting-Ting Wang Yu-Ting Hou Yingzhen Yang Bin Mei Xue-Sheng Liu Yao Lu Shan-Gui Chen Source Type: research

Modulation of secretory factors by lipofundin contributes to its anti ‑neuroinflammatory effects
Exp Ther Med. 2024 Feb 27;27(4):169. doi: 10.3892/etm.2024.12456. eCollection 2024 Apr.ABSTRACTAs the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases. Lipofundin is a lipid emulsion commonly used in clinical anesthetic solvents and nutritional supplements. Lipid emulsions have been shown to possess anti-inflammatory properties. However, the potential beneficial effect of lipofundin against neuroinflammation require...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Ming-Shan Chen Chia-Lin Hu Shin-Kuang Jiang Zhi-Yong Chong Jui-Chieh Chen Source Type: research

Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review)
Exp Ther Med. 2024 Feb 20;27(4):149. doi: 10.3892/etm.2024.12437. eCollection 2024 Apr.ABSTRACTV-Raf murine sarcoma viral oncogene homolog B1 (BRAF) encodes a serine-threonine kinase. The V600E point mutation in the BRAF gene is the most common mutation, predominantly occurring in melanoma, and colorectal, thyroid and non-small cell lung cancer. Particularly in the context of thyroid cancer research, it is routinely employed as a molecular biomarker to assist in diagnosing and predicting the prognosis of papillary thyroid cancer (PTC), and to formulate targeted therapeutic strategies. Currently, several methods are utilize...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Qian Liu Xue Jiang Wenling Tu Lina Liu Ying Huang Yuxiao Xia Xuliang Xia Yuhong Shi Source Type: research

Secondary bladder stone caused by delayed penetration of the bladder by a pubic fracture: A case report and literature review
Exp Ther Med. 2024 Feb 27;27(4):167. doi: 10.3892/etm.2024.12455. eCollection 2024 Apr.ABSTRACTPelvic fractures sometimes lead to injuries of the urinary bladder, which commonly present as gross hematuria, dysuria and lower abdominal pain. As a type of urinary stone, bladder stones are usually secondary to lower urinary tract obstruction, such as benign prostatic hyperplasia, urethral stricture, and neurogenic bladder. The present case report examines an unusual case of a delayed pubic fracture penetrating the bladder, which caused a secondary bladder stone. A 53-year-old man was first hospitalized at The Second Hospital o...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xinghao Wang Xiao Guo Zhiling Tang Xiangjun Ying Chenye Tang Ruilin Shen Source Type: research

Type  B3 thymoma complicated with < em > Chlamydia psittaci < /em > pneumonia with rare features: A case report
Exp Ther Med. 2024 Feb 20;27(4):153. doi: 10.3892/etm.2024.12441. eCollection 2024 Apr.ABSTRACTThe case of a patient with type B3 thymomacomorbid with Chlamydia psittaci (C. psittaci) pneumonia exhibiting rare features is presented in the current report. The patient was admitted at the Second Affiliated Hospital of Jiaxing University (Jiaxing, China) with a history of direct contact with poultry. Clinical manifestations included fever, shivers, cough, fatigue and poor appetite. Chest computed tomography (CT) indicated right lung pneumonia, while metagenomics next-generation sequencing using bronchoalveolar lavage fluid con...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Jianping Jiang Jinmeng Dai Xun Hu Xiujuan Yao Weiqiang Mo Haiqin Wang Source Type: research

Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats
Exp Ther Med. 2024 Feb 15;27(4):143. doi: 10.3892/etm.2024.12431. eCollection 2024 Apr.ABSTRACTNotoginseng saponins (NS) are the active ingredients in Panax notoginseng (Burk.) F.H. Chen (PN). NS can be transformed depending on how the extract is processed. Fermentation has been shown to produce secondary ginsenosides with increased bioavailability. However, the therapeutic effect of fermented NS (FNS) requires further study. The present study compared the compositions and activities of FNS and NS in blood deficiency rats, which resembles the symptoms of anemia in modern medicine, induced by acetylphenylhydrazine and cyclo...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Wenjie Su Zuguo Liang Daian Pan Lancao Zhang Yuyao Zhang Tongyi Yuan Xiang Gao Hang Su He Zhang Source Type: research