A long ‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report
Exp Ther Med. 2024 Apr 24;27(6):263. doi: 10.3892/etm.2024.12551. eCollection 2024 Jun.ABSTRACTEstablished treatments for advanced hepatocellular carcinoma (HCC) with Child-Pugh cirrhosis B (CPB, moderate hepatic dysfunction) are lacking. A recently published randomized phase 2 study in CPB HCC investigating the safety and efficacy of namodenoson (25 mg BID), an A3 adenosine-receptor agonist vs. placebo, suggested a favorable safety profile and a positive efficacy signal in patients with HCC with a CPB score of 7 (CPB7). The present study reports a 61-year-old woman with CPB7 HCC who received namodenoson for over 6 years t...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Ioana Adriana Ciurescu Riccardo Lencioni Salomon M Stemmer Motti Farbstein Zivit Harpaz Avital Bareket-Samish Michael H Silverman Pnina Fishman Source Type: research

CB1 receptor mediates anesthetic drug ketamine ‑induced neuroprotection against glutamate in HT22 cells
Exp Ther Med. 2024 Apr 26;27(6):268. doi: 10.3892/etm.2024.12556. eCollection 2024 Jun.ABSTRACTThe anesthetic drug, ketamine (KTM) has been shown to induce therapeutic effects against major depressive disorder (MDD), however the related underlying mechanisms remain unclear. In the present study, HT22 neuronal cells were treated with glutamate to imitate oxidative stress injury in MDD, and it was hypothesized that the cannabinoid type 1 (CB1) receptor mediates KTM-induced neuroprotection via ameliorating mitochondrial function in glutamate-treated neuronal cells. Compared with the control, glutamate decreased cell viability...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: He Bao Chen Wang Xiaorong Xue Bin Hu Qi Guo Source Type: research

S1PR3 suppresses the inflammatory response and extracellular matrix degradation in human nucleus pulposus cells
In conclusion, STAT3 overexpression suppressed viability injury, the inflammatory response and the level of apoptosis and alleviated ECM protein deposition in HNPCs through the TLR2/STAT3 and TLR2/MAPK pathways, which may offer a promising candidate for the amelioration of intervertebral disc degeneration.PMID:38756905 | PMC:PMC11097297 | DOI:10.3892/etm.2024.12553 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Zhen Tian Haoran Gao Wenjun Xia Zhaohui Lou Source Type: research

Ossifying fibromyxoid tumor of the soft tissue in the left upper arm and a review of the literature: A case report
Exp Ther Med. 2024 Apr 23;27(6):261. doi: 10.3892/etm.2024.12549. eCollection 2024 Jun.ABSTRACTOssifying fibromyxoid tumor (OFMT) of the soft parts is a mesenchymal neoplasm of uncertain lineage. Fibromyxoid matrix and peripheral metaplastic bone are common histological features of this type of tumor. In the present study, a case of OFMT in a 33-year-old female was reported. The patient was referred to the First Affiliated Hospital of China Medical University (Shenyan, China) in January 2018. The patient had developed a mass in the left upper arm 6 months prior to presentation, which was slowly enlarging. The tumor was 1.5...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Nan Liu Yuefeng Jiang Jiang Du Chuifeng Fan Source Type: research

Association of IL ‑6 and MMP‑3 gene polymorphisms with adolescent idiopathic scoliosis: A systematic review and meta‑analysis
Exp Ther Med. 2024 Apr 26;27(6):267. doi: 10.3892/etm.2024.12555. eCollection 2024 Jun.ABSTRACTThe pathogenesis of adolescent idiopathic scoliosis (AIS) remains unclear. It has been found that interleukin-6 (IL-6) rs1800795 locus and matrix metalloproteinase-3 (MMP-3) rs3025058 locus gene polymorphisms may be associated with AIS susceptibility, which has been controversial and needs to be further confirmed by updated meta-analysis. The aim of the present study was to investigate the association of MMP-3 rs3025058 and IL-6 rs1800795 single nucleotide polymorphisms (SNPs) with susceptibility to AIS. All relevant articles tha...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Yue-Peng Wang Shi-Lei Qin Su Yang Yun-Feng Xu Peng-Fei Han Ai-Hua Liu Ke-Dong Hou Jian-Ping He Source Type: research

Role of non ‑coding RNAs in UV‑induced radiation effects (Review)
Exp Ther Med. 2024 Apr 23;27(6):262. doi: 10.3892/etm.2024.12550. eCollection 2024 Jun.ABSTRACTUltraviolet (UV) is divided into UVA (long-wave, 320-400 nm), UVB (middle-wave, 280-320 nm) and UVC (short-wave, 100-280 nm) based on wavelength. UV radiation (UVR) from sunlight (UVA + UVB) is a major cause of skin photodamage including skin inflammation, aging and pigmentation. Accidental exposure to UVC burns the skin and induces skin cancer. In addition to the skin, UV radiation can also impair visual function. Non-coding RNAs (ncRNAs) are a class of functional RNAs that do not have coding activity but can control cellular pr...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Xiaofei Liang Chao Zhang Lijuan Shen Ling Ding Haipeng Guo Source Type: research

Effects of magnesium sulfate combined with labetalol on inflammatory stress and pregnancy outcome of patients with gestational hypertension
In conclusion, MgSO4 + labetalol could improve inflammatory stress and the hemodynamics of patients with GH, and may have a marked antihypertensive effect. Thus, it may improve pregnancy outcome and reduce perinatal complications.PMID:38756909 | PMC:PMC11097299 | DOI:10.3892/etm.2024.12554 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Zhijuan Gu Wenqing Gu Guiping Zhang Ye Tang Minfang Wang Yan Guo Liping Zhou Source Type: research

Value of conventional ultrasound and shear ‑wave elastography in the assessment of mesenteric lymphadenitis in a paediatric population
Exp Ther Med. 2024 Apr 23;27(6):259. doi: 10.3892/etm.2024.12547. eCollection 2024 Jun.ABSTRACTThe present retrospective study was designed to explore the value of conventional ultrasound (US) and Virtual Touch Tissue Imaging and Quantification (VTIQ) in the assessment of mesenteric lymphadenitis (ML) in a paediatric population. A total of 103 patients with ML and 60 healthy paediatric patients were examined. VTIQ was performed to assess mesenteric lymph node (MLN) stiffness via shear-wave velocity (SWV). Univariate and multivariate logistic regression analyses were conducted to reveal independent variables for the identif...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Li Zhou Jun Shan Dao-Ming Zu Shu-Hao Deng Yuan Zhang Xiu-Rong Shi Yi-Cheng Zhu Quan Jiang Source Type: research

Identification of novel variations in three cases with rare inherited neuromuscular disorder
In conclusion, the present study expanded the IND mutation spectrum. The study not only detailed the precise diagnoses of these cases but also furnished substantial grounds for informed consultations. The approach involving the genetic evaluation strategy using WES for variation screening followed by validation using appropriate methods is beneficial due to the considerable heterogeneity of IND.PMID:38756899 | PMC:PMC11097291 | DOI:10.3892/etm.2024.12558 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Wen-Qi Chen Yu-Fan Yuan Ke-Na Hu Dong-Lan Sun Si-Wen Wang Qing-Bing He Yan-Ming Liu Cong-Ying Han Jing Zhang Ya-Zhou Li Source Type: research

Changes in the intestinal microbiota of multiple myeloma patients living in high ‑altitude and cold regions analyzed using 16s rRNA high‑throughput sequencing
Exp Ther Med. 2024 Apr 29;27(6):269. doi: 10.3892/etm.2024.12557. eCollection 2024 Jun.ABSTRACTMultiple myeloma (MM) is a plasma cell clonal disease and these plasma cells can survive in the gut. The intestinal microbiota is a complex ecosystem and its dysfunction can release persistent stimulus signals that trigger genetic mutations and clonal evolution in the gut. The present study analyzed the intestinal microbiota in fecal samples of MM patients in high-altitude and cold regions of China using 16s rRNA sequencing and analyzed significantly enriched species at the phylum and genus levels. Although no significant differe...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Xiaofei Liang Xuyang Guo Huixin Jin Lijuan Shen Ling Ding Xin Guan Yujie Kou Yi Wu Haipeng Guo Source Type: research

Disseminated central nervous system tuberculoma in a patient with scrub typhus: A case report
Exp Ther Med. 2024 Apr 23;27(6):260. doi: 10.3892/etm.2024.12548. eCollection 2024 Jun.ABSTRACTCentral nervous system (CNS) tuberculosis mainly manifests as tuberculous meningitis and intracranial tuberculosis; intramedullary tuberculosis is uncommon. Scrub typhus is an acute naturally occurring infectious disease caused by Orientia tsutsugamushi. CNS tuberculoma following typhus is rare. The present study described a 60-year-old man with high fever, muscle soreness, yellowish skin and sclera and hepatosplenomegaly. At first, the patient was diagnosed with scrub typhus, after treatment with doxycycline he recovered complet...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Yachun Yu Guohua He Source Type: research

Erratum: [Corrigendum] Aloperine activates the Nrf2 ‑ARE pathway when ameliorating early brain injury in a subarachnoid hemorrhage model
Exp Ther Med. 2024 Apr 25;27(6):264. doi: 10.3892/etm.2024.12552. eCollection 2024 Jun.ABSTRACT[This corrects the article DOI: 10.3892/etm.2018.5896.].PMID:38756902 | PMC:PMC11097296 | DOI:10.3892/etm.2024.12552 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Shibin Song Yimin Chen Feng Han Minghao Dong Xin Xiang Jianmei Sui Yuming Li Hua Yang Jian Liu Source Type: research

A long ‑term complete response to namodenoson in liver cancer with Child‑Pugh B cirrhosis: A case report
Exp Ther Med. 2024 Apr 24;27(6):263. doi: 10.3892/etm.2024.12551. eCollection 2024 Jun.ABSTRACTEstablished treatments for advanced hepatocellular carcinoma (HCC) with Child-Pugh cirrhosis B (CPB, moderate hepatic dysfunction) are lacking. A recently published randomized phase 2 study in CPB HCC investigating the safety and efficacy of namodenoson (25 mg BID), an A3 adenosine-receptor agonist vs. placebo, suggested a favorable safety profile and a positive efficacy signal in patients with HCC with a CPB score of 7 (CPB7). The present study reports a 61-year-old woman with CPB7 HCC who received namodenoson for over 6 years t...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Ioana Adriana Ciurescu Riccardo Lencioni Salomon M Stemmer Motti Farbstein Zivit Harpaz Avital Bareket-Samish Michael H Silverman Pnina Fishman Source Type: research

CB1 receptor mediates anesthetic drug ketamine ‑induced neuroprotection against glutamate in HT22 cells
Exp Ther Med. 2024 Apr 26;27(6):268. doi: 10.3892/etm.2024.12556. eCollection 2024 Jun.ABSTRACTThe anesthetic drug, ketamine (KTM) has been shown to induce therapeutic effects against major depressive disorder (MDD), however the related underlying mechanisms remain unclear. In the present study, HT22 neuronal cells were treated with glutamate to imitate oxidative stress injury in MDD, and it was hypothesized that the cannabinoid type 1 (CB1) receptor mediates KTM-induced neuroprotection via ameliorating mitochondrial function in glutamate-treated neuronal cells. Compared with the control, glutamate decreased cell viability...
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: He Bao Chen Wang Xiaorong Xue Bin Hu Qi Guo Source Type: research

S1PR3 suppresses the inflammatory response and extracellular matrix degradation in human nucleus pulposus cells
In conclusion, STAT3 overexpression suppressed viability injury, the inflammatory response and the level of apoptosis and alleviated ECM protein deposition in HNPCs through the TLR2/STAT3 and TLR2/MAPK pathways, which may offer a promising candidate for the amelioration of intervertebral disc degeneration.PMID:38756905 | PMC:PMC11097297 | DOI:10.3892/etm.2024.12553 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - May 17, 2024 Category: General Medicine Authors: Zhen Tian Haoran Gao Wenjun Xia Zhaohui Lou Source Type: research