Experimental and Therapeutic Medicine 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Treatment opinions for dens invaginatus: A case series
Exp Ther Med. 2024 Feb 13;27(4):138. doi: 10.3892/etm.2024.12426. eCollection 2024 Apr.ABSTRACTDens invaginatus (DI) is a rare congenital dental malformation characterized by enamel or cementum folded into dentine. Such teeth are susceptible to caries, pulp infection or necrosis and periradicular lesion. The complex anatomy of this disease results in difficult treatment and a high rate of therapeutic failure. Therapeutic options, such as debriding and filling invagination, root canal treatment (RCT) and intentional replantation, vary according to the morphology and infection of the involved tooth. The present study reports...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Chengshi Wei Dong Wang Lili Shen Ping Lu Zhen Meng Rongjing Zhou Source Type: research
Epidemiological insights into seasonal, sex ‑specific and age‑related distribution of bacterial pathogens in urinary tract infections
Exp Ther Med. 2024 Feb 14;27(4):140. doi: 10.3892/etm.2024.12428. eCollection 2024 Apr.ABSTRACTUrinary tract infections (UTIs) are prevalent and recurrent bacterial infections that affect individuals worldwide, posing a significant burden on healthcare systems. The present study aimed to explore the epidemiology of UTIs, investigating the seasonal, gender-specific and age-related bacterial pathogen distribution to guide clinical diagnosis. Data were retrospectively collected from electronic medical records and laboratory reports of 926 UTIs diagnosed in Fuding Hospital (Fujian University of Traditional Chinese Medicine, Fu...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Zhi-Song Zhan Jing Shi Zu-Shun Zheng Xue-Xia Zhu Juan Chen Xin-Yi Zhou Shi-Yan Zhang Source Type: research
Clinical application of a connection device consisting of a bag valve mask and nebulizer in first aid: Two case reports
Exp Ther Med. 2024 Feb 28;27(4):172. doi: 10.3892/etm.2024.12460. eCollection 2024 Apr.ABSTRACTIn clinical practice, several emergencies may threaten the life of patients, and these emergencies can be unpredictable and challenging. During the coronavirus disease 2019 pandemic, in January 2023, a patient developed respiratory distress caused by coronavirus, but was unable to access respiratory support due to shortages of medical resources, intensive care unit beds and ventilators. The medical staff quickly created a portable high-flow atomized oxygen therapy apparatus consisting of a simple breathing bag connected to a nebu...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Ting-Ting Wang Yu-Ting Hou Yingzhen Yang Bin Mei Xue-Sheng Liu Yao Lu Shan-Gui Chen Source Type: research
Modulation of secretory factors by lipofundin contributes to its anti ‑neuroinflammatory effects
Exp Ther Med. 2024 Feb 27;27(4):169. doi: 10.3892/etm.2024.12456. eCollection 2024 Apr.ABSTRACTAs the global population ages, the prevalence of neuroinflammatory diseases such as Alzheimer's disease, Parkinson's disease and stroke continues to increase. Therefore, it is necessary to develop preventive and therapeutic methods against neuroinflammatory diseases. Lipofundin is a lipid emulsion commonly used in clinical anesthetic solvents and nutritional supplements. Lipid emulsions have been shown to possess anti-inflammatory properties. However, the potential beneficial effect of lipofundin against neuroinflammation require...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Ming-Shan Chen Chia-Lin Hu Shin-Kuang Jiang Zhi-Yong Chong Jui-Chieh Chen Source Type: research
Comparative efficiency of differential diagnostic methods for the identification of BRAF V600E gene mutation in papillary thyroid cancer (Review)
Exp Ther Med. 2024 Feb 20;27(4):149. doi: 10.3892/etm.2024.12437. eCollection 2024 Apr.ABSTRACTV-Raf murine sarcoma viral oncogene homolog B1 (BRAF) encodes a serine-threonine kinase. The V600E point mutation in the BRAF gene is the most common mutation, predominantly occurring in melanoma, and colorectal, thyroid and non-small cell lung cancer. Particularly in the context of thyroid cancer research, it is routinely employed as a molecular biomarker to assist in diagnosing and predicting the prognosis of papillary thyroid cancer (PTC), and to formulate targeted therapeutic strategies. Currently, several methods are utilize...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Qian Liu Xue Jiang Wenling Tu Lina Liu Ying Huang Yuxiao Xia Xuliang Xia Yuhong Shi Source Type: research
Secondary bladder stone caused by delayed penetration of the bladder by a pubic fracture: A case report and literature review
Exp Ther Med. 2024 Feb 27;27(4):167. doi: 10.3892/etm.2024.12455. eCollection 2024 Apr.ABSTRACTPelvic fractures sometimes lead to injuries of the urinary bladder, which commonly present as gross hematuria, dysuria and lower abdominal pain. As a type of urinary stone, bladder stones are usually secondary to lower urinary tract obstruction, such as benign prostatic hyperplasia, urethral stricture, and neurogenic bladder. The present case report examines an unusual case of a delayed pubic fracture penetrating the bladder, which caused a secondary bladder stone. A 53-year-old man was first hospitalized at The Second Hospital o...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xinghao Wang Xiao Guo Zhiling Tang Xiangjun Ying Chenye Tang Ruilin Shen Source Type: research
Type B3 thymoma complicated with < em > Chlamydia psittaci < /em > pneumonia with rare features: A case report
Exp Ther Med. 2024 Feb 20;27(4):153. doi: 10.3892/etm.2024.12441. eCollection 2024 Apr.ABSTRACTThe case of a patient with type B3 thymomacomorbid with Chlamydia psittaci (C. psittaci) pneumonia exhibiting rare features is presented in the current report. The patient was admitted at the Second Affiliated Hospital of Jiaxing University (Jiaxing, China) with a history of direct contact with poultry. Clinical manifestations included fever, shivers, cough, fatigue and poor appetite. Chest computed tomography (CT) indicated right lung pneumonia, while metagenomics next-generation sequencing using bronchoalveolar lavage fluid con...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Jianping Jiang Jinmeng Dai Xun Hu Xiujuan Yao Weiqiang Mo Haiqin Wang Source Type: research
Therapeutic effect of notoginseng saponins before and after fermentation on blood deficiency rats
Exp Ther Med. 2024 Feb 15;27(4):143. doi: 10.3892/etm.2024.12431. eCollection 2024 Apr.ABSTRACTNotoginseng saponins (NS) are the active ingredients in Panax notoginseng (Burk.) F.H. Chen (PN). NS can be transformed depending on how the extract is processed. Fermentation has been shown to produce secondary ginsenosides with increased bioavailability. However, the therapeutic effect of fermented NS (FNS) requires further study. The present study compared the compositions and activities of FNS and NS in blood deficiency rats, which resembles the symptoms of anemia in modern medicine, induced by acetylphenylhydrazine and cyclo...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Wenjie Su Zuguo Liang Daian Pan Lancao Zhang Yuyao Zhang Tongyi Yuan Xiang Gao Hang Su He Zhang Source Type: research
Cancer ‑associated fibroblasts under therapy‑induced senescence in the tumor microenvironment (Review)
Exp Ther Med. 2024 Feb 20;27(4):150. doi: 10.3892/etm.2024.12438. eCollection 2024 Apr.ABSTRACTCurrent cancer treatments target tumor cells; however, the tumor microenvironment (TME) induces therapeutic resistance, tumor development and metastasis, thus rendering these treatments ineffective. Research on the TME has therefore concentrated on nonmalignant cells. Cancer-associated fibroblasts (CAFs) are a major TME component, which contribute to cancer progression due to their diverse origins, phenotypes and functions, including cancer cell invasion and migration, extracellular matrix remodeling, tumor metabolism modulation ...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Qiuhua Zhang Yijie Lou Hao Fang Shaopeng Sun Rijuan Jin Yunxi Ji Zhe Chen Source Type: research
Novel underlying genetic markers for asthenozoospermia due to abnormal spermatogenesis and reproductive organ inflammation
Exp Ther Med. 2024 Feb 19;27(4):146. doi: 10.3892/etm.2024.12434. eCollection 2024 Apr.ABSTRACTAsthenozoospermia, a male fertility disorder, has a complex and multifactorial etiology. Moreover, the effectiveness of different treatments for asthenozoospermia remains uncertain. Hence, by using bioinformatics techniques, the present study aimed to determine the underlying genetic markers and pathogenetic mechanisms associated with asthenozoospermia due to abnormal spermatogenesis and inflammation of the reproductive tract. GSE160749 dataset was downloaded from the Gene Expression Omnibus database, and the data were filtered t...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Yaodong Zhang Yun Peng Yao Wang Jian Xu Hongli Yan Source Type: research
Erratum: [Corrigendum] Pien Tze Huang inhibits hypoxia ‑induced epithelial‑mesenchymal transition in human colon carcinoma cells through suppression of the HIF‑1 pathway
Exp Ther Med. 2024 Feb 28;27(4):170. doi: 10.3892/etm.2024.12458. eCollection 2024 Apr.ABSTRACT[This corrects the article DOI: 10.3892/etm.2014.1549.].PMID:38476924 | PMC:PMC10928845 | DOI:10.3892/etm.2024.12458 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Hongwei Chen Aling Shen Yuchen Zhang Youqin Chen Jiumao Lin Wei Lin Thomas Sferra Jun Peng Source Type: research
Neuroprotective effects of galectin ‑1 on cerebral ischemia/reperfusion injury by regulating oxidative stress
Exp Ther Med. 2024 Feb 20;27(4):154. doi: 10.3892/etm.2024.12442. eCollection 2024 Apr.ABSTRACTOxidative stress contributes to the pathology of cerebral ischemia/reperfusion (I/R) injury. Galectin-1 has shown an anti-oxidative stress effect. The present study investigated whether this anti-oxidative stress effect can account for the neuroprotective actions of galectin-1 induced by cerebral I/R injury. A cerebral I/R injury model was created in C57Bl/6 mice by transient occlusion of the middle cerebral artery, after which the mice were treated with galectin-1 for 3 days. Infarct volumes were measured. A rotarod test and neu...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Jie Zhao Rui Zhu Feifei He Miao Wu Yufu Wu Xiangjun Meng Xiaohong Liu Source Type: research
[Retracted] microRNA ‑146b promotes neuroblastoma cell growth through targeting NUMB
Exp Ther Med. 2024 Feb 13;27(4):136. doi: 10.3892/etm.2024.12424. eCollection 2024 Apr.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.8623.].PMID:38476884 | PMC:PMC10928818 | DOI:10.3892/etm.2024.12424 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiao-Li Ma Xiao-Juan Zhang Qian Du Xiang-Nan Zhang Shu-Yan Zhang Huan-Fen Zhao Source Type: research
Erdheim ‑Chester disease of multisystem involvement with delayed diagnosis: A case report and literature review
Exp Ther Med. 2024 Feb 22;27(4):159. doi: 10.3892/etm.2024.12447. eCollection 2024 Apr.ABSTRACTErdheim-Chester disease (ECD) is a rare tumor of histiocytic origin, characterized by foamy or lipid-laden histiocytes mixed or surrounded by fibrosis that infiltrate multiple organs. Misdiagnosis is common due to the diversity of clinical presentations. The present study reported a case of ECD with the involvements of bone, cardiac, aorta and retroperitoneum. The patient had no obvious clinical symptoms and no noteworthy foamy histiocytes or Touton giant cells were found on pathological examination, delaying the diagnosis. The p...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Xiaotong Shi Guangzhi Sun Tongguan Li Mengjiao Xu Yixuan Liu Zhankui Wang Yanfeng Hou Source Type: research
Programmed cell death 4 blocks autophagy and promotes dopaminergic neuronal injury in Parkinson's disease
Exp Ther Med. 2024 Feb 12;27(4):135. doi: 10.3892/etm.2024.12423. eCollection 2024 Apr.ABSTRACTDysregulation of autophagy has previously been associated with the formation of toxic proteins, such as α-synuclein, in patients with Parkinson's disease (PD). In addition, it has been indicated that programmed cell death 4 (PDCD4) can inhibit autophagy in certain conditions, such as diabetic nephropathy, atherosclerosis and cardiac hypertrophy. Therefore, the hypothesis that PDCD4 can promote dopaminergic neuron damage through autophagy was proposed. To explore this hypothesis, the present study treated human neuroblastoma SK-N...
Source: Experimental and Therapeutic Medicine - March 13, 2024 Category: General Medicine Authors: Guiling Cao Tao Kang Nini Li Peng Li Source Type: research
