Experimental and Therapeutic Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Proteinase ‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report
Exp Ther Med. 2024 Mar 20;27(5):216. doi: 10.3892/etm.2024.12504. eCollection 2024 May.ABSTRACTA 58-year-old male patient was admitted to Peking University First Hospital (Beijing, China) due to recurrent hematuria, proteinuria and kidney dysfunction. The patient was positive for proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA). Pathology of the kidney showed focal proliferative necrotizing glomerulonephritis with crescent formation and immune complex-mediated glomerulonephritis. The patient was diagnosed with PR3-ANCA-associated vasculitis (AAV), received intensive immunosuppressive therapy and experienced tw...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Hui Lu Zhao Cui Xu-Jie Zhou Ying Yang Xiao-Ning Han Xi-Hui Li Fu-De Zhou Ming-Hui Zhao Source Type: research

Identification of common genes of rhinovirus single/double ‑stranded RNA‑induced asthma deterioration by bioinformatics analysis
Exp Ther Med. 2024 Mar 20;27(5):210. doi: 10.3892/etm.2024.12498. eCollection 2024 May.ABSTRACTRhinovirus (RV) is the most common respiratory virus affecting humans. The majority of asthma deteriorations are triggered by RV infections. However, whether the effects of RV single- and double-stranded RNA on asthma deterioration have common target genes needs to be further studied. In the present study, two datasets (GSE51392 and GSE30326) were used to screen for common differentially expressed genes (cDEGs). The molecular function, signaling pathways, interaction networks, hub genes, key modules and regulatory molecules of cD...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Qian An Yi Cao Wei Guo Ziyun Jiang Hui Luo Hui Liu Xiaodong Zhan Source Type: research

A study of the molecular mechanism of action of Jiawei Guizhishaoyaozhimu Decoction during rheumatoid arthritis therapy based on basic of network pharmacology and experimental verification
Exp Ther Med. 2024 Mar 20;27(5):212. doi: 10.3892/etm.2024.12499. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease, which primarily affects the joints. The aim of the present study was to predict the main active ingredients of Jiawei Guizhishaoyaozhimu Decoction (JWGZSYZMD) and potential targets of this treatment during RA therapy by using molecular docking and network pharmacology methods. In addition, another aim was to investigate the therapeutic effects and mechanism of JWGZSYZMD on joint inflammation in rat models of collagen Ⅱ-induced arthritis (CIA). JWGZSYZMD ingredients and ...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yiji Cheng Yue Ji Kaidi Feng Xinyuan Zhang Yunming Xiao Weixia Jing Source Type: research

Recent development of oral vaccines (Review)
Exp Ther Med. 2024 Mar 22;27(5):223. doi: 10.3892/etm.2024.12511. eCollection 2024 May.ABSTRACTOral immunization can elicit an effective immune response and immune tolerance to specific antigens. When compared with the traditional injection route, delivering antigens via the gastrointestinal mucosa offers superior immune effects and compliance, as well as simplicity and convenience, making it a more optimal route for immunization. At present, various oral vaccine delivery systems exist. Certain modified bacteria, such as Salmonella, Escherichia coli and particularly Lactobacillus, are considered promising carriers for oral...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Ying Liu Dominic Man-Kit Lam Mei Luan Wenfu Zheng Hao Ai Source Type: research

Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells
Exp Ther Med. 2024 Mar 21;27(5):217. doi: 10.3892/etm.2024.12505. eCollection 2024 May.ABSTRACTTotal saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and anti-gastric ulcer effects. Bupleurum or TSS is frequently utilized in clinical practice alongside other medications (such as entecavir, lamivudine, compound paracetamol and amantadine hydrochloride capsules), leading to an increased risk of drug-drug interactions. The cytochrome P450 (CYP) fam...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yunyan Tang Hongfang Li Jianhua Tang Lei Hu Feifei Ma Yanmiao Liu Fushan Tang Source Type: research

Vigeo attenuates cartilage and bone destruction in a collagen ‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines
Exp Ther Med. 2024 Mar 19;27(5):208. doi: 10.3892/etm.2024.12496. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease characterized by articular cartilage destruction, bone destruction and synovial hyperplasia. It has been suggested that Vigeo, a mixture of Eleutherococcus senticosus, Achyranthes japonica and Atractylodes japonica fermented with Korean nuruk, has an anti-osteoporotic effect in a mouse model of inflammation-mediated bone loss. The present study evaluated the therapeutic effects of Vigeo in RA using a collagen-induced arthritis (CIA) mouse model. DBA/1J mi...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yoon-Hee Cheon Chang Hoon Lee So Young Eun Gyeong Do Park Chong Hyuk Chung Ju-Young Kim Myeung Su Lee Source Type: research

Immune profile of patients ‑a new approach in management of sepsis and septic shock?
Exp Ther Med. 2024 Mar 15;27(5):203. doi: 10.3892/etm.2024.12489. eCollection 2024 May.ABSTRACTThe present study was a prospective observational single center study, enrolling 102 patients with sepsis, admitted in the Intensive Care Unit of the County Emergency Clinical Hospital in Târgu Mureș (Mureș, Romania). The main goal of the present study was to compare the changes of the following parameters on day 1 compared with day 5, in sepsis compared with septic shock, as well as in survivors compared with non-survivors: Cell blood count parameters, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and systemic inflam...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Anca Bac ârea Oana Coman Vladimir Constantin Bac ârea Anca Meda V ăsieşiu Irina S ăplăcan Raluca Śtefania Fodor Bianca Liana Grigorescu Source Type: research

Airway basal cell ‑derived exosomes suppress epithelial‑mesenchymal transition of lung cells by inhibiting the expression of ANO1
In conclusion, airway basal cell-derived exosomes suppressed the EMT of lung cells via the downregulation of ANO1. These exosomes represent a potential therapeutic option for patients with IPF.PMID:38590572 | PMC:PMC11000454 | DOI:10.3892/etm.2024.12507 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Xiaohua Gu Zeyu Liu Shan Shan Tao Ren Shaoyang Wang Source Type: research

Management of intracranial cavernous malformations using conservative vs. surgical and/or radiosurgical treatment: A systematic review and meta ‑analysis
Exp Ther Med. 2024 Mar 20;27(5):215. doi: 10.3892/etm.2024.12503. eCollection 2024 May.ABSTRACTIntracranial cavernous malformations (CMs) are vascular lesions with a high bleeding rate. At present, the debate regarding their treatment is still ongoing. The present systematic review and meta-analysis aimed to evaluate the safety of surgery or radiosurgery (SRS) for the management of CMs and to determine their potential outcomes compared with conservative treatment. The present systematic review and meta-analysis investigated the relative articles involving the management of intracranial CMs, namely their natural history (co...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: George Fotakopoulos Vasiliki Epameinondas Georgakopoulou Petros Papalexis Demetrios A Spandidos Nikolaos Trakas Pagona Sklapani Kostas N Fountas Source Type: research

Endothoracic lymphatic plexus ‑hemiazygos vein anastomosis for chylothorax complicated with hepatocellular carcinoma: A case report
In conclusion, LVA could be appropriate to treat chylothorax when TDL is ineffective as a remedial or even prophylactic intervention.PMID:38590574 | PMC:PMC11000049 | DOI:10.3892/etm.2024.12495 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yi Jiang Cong Liu Yingtong Huang Naiquan Mao Xiaoming Liao Source Type: research

Clinical presentation of severe COVID ‑19 with heart failure: A single‑center retrospective study
In conclusion, HF combined with COVID-19, treatment and prognosis are getting worse. Enhancing preparedness for future COVID-19 and other similar pandemics necessitates the comprehension of this to refine care provided to patients with HF (registration no. THH-IPR-20221101 on 01 November 2022).PMID:38590575 | PMC:PMC11000051 | DOI:10.3892/etm.2024.12481 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Xinling Liu Tingting Liu Rong Wan Source Type: research

Treatment of rectal anastomotic atresia with transurethral prostate resection instrumentation: A report of three cases
Exp Ther Med. 2024 Mar 15;27(5):202. doi: 10.3892/etm.2024.12491. eCollection 2024 May.ABSTRACTDixon surgery for rectal cancer can lead to severe intestinal narrowing and blockage that is difficult to treat with open surgery or colonoscopy. The aim of the present study was to develop a minimally invasive approach for treating rectal anastomotic atresia based on three cases that were managed with transurethral prostate resection instrumentation. Preoperative imaging determined the distance from the anastomotic closure to the anal margin, the length of the anastomotic closure and the degree of proximal intestinal dilation fo...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Zhentao Hu Yujie Qin Xiaoyi Wei Jun Qian Song Tu Jiaxi Yao Source Type: research

Comparative quantitative analysis of optical coherence tomography angiography in varied morphologies of macular neovascularization following intravitreal conbercept and ranibizumab treatments for neovascular age ‑related macular degeneration
Exp Ther Med. 2024 Mar 20;27(5):214. doi: 10.3892/etm.2024.12501. eCollection 2024 May.ABSTRACTThe present study aimed to examine the optical coherence tomography angiography (OCTA) parameters associated with macular neovascularization (MNV) in patients diagnosed with neovascular age-related macular degeneration (nAMD) and treated with either intravitreal conbercept (IVC) or ranibizumab (IVR). It enrolled 39 nAMD patients presenting with MNV, including 23 in the IVC group and 16 in the IVR group. All participants were treatment-naïve with intravitreal therapy and they underwent treatment following a '3+PRN' regimen. The M...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Jing Li Zhufang Yang Xueying Li Di Li Jin Yang Meijia Dang Source Type: research

Eukaryotic translation initiation factor < em > EIF4G1 < /em > p.Ser637Cys mutation in a family with Parkinson's disease with antecedent essential tremor
In conclusion, the results from the present study suggested that EIF4G1 may be responsible for the hereditary PD with 'antecedent ET' reported in the family assessed.PMID:38590578 | PMC:PMC11000071 | DOI:10.3892/etm.2024.12494 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Rui-Han Liu Xiang-Yu Xiao Lei Yao Yuan-Yuan Jia Jia Guo Xing-Chen Wang Yu Kong Qing-Xia Kong Source Type: research

RFC3 drives the proliferation, migration, invasion and angiogenesis of colorectal cancer cells by binding KIF14
In conclusion, RFC3 might interact with KIF14 to function as a contributor to the malignant development of CRC.PMID:38590579 | PMC:PMC11000453 | DOI:10.3892/etm.2024.12510 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Rong Yu Xinxin Wu Fang Qian Qian Yang Source Type: research