Bulk and single cells transcriptomes with experimental validation identify USP18 as a novel glioma prognosis and proliferation indicator
In conclusion, the present study demonstrated that knockdown of USP18 expression inhibited the proliferation of glioma cells, which may be mediated by the effect of USP18 on the IFN-I response.PMID:38596661 | PMC:PMC11002833 | DOI:10.3892/etm.2024.12517 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Yang Chen Ren Li Ziao Li Biao Yang Jianhang He Jiayu Li Peize Li Zihan Zhou Yongqiang Wu Yuanli Zhao Geng Guo Source Type: research

Role of co ‑inhibitory molecules in the treatment of psoriasis (Review)
Exp Ther Med. 2024 Mar 19;27(5):209. doi: 10.3892/etm.2024.12497. eCollection 2024 May.ABSTRACTPsoriasis is a common chronic inflammatory skin disease characterized by abnormal activation and infiltration of T-cells and excessive proliferation of keratinocytes (KCs). Its pathogenesis is complex and frequently accompanied by the imbalance of T-cell subpopulations, contributing to its development and further exacerbation. Therefore, the immune system, especially T-cells, is mainly involved in the pathogenesis of psoriasis. While T-cell activation not only requires the first recognition of T-cell receptor and major histocompa...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yue Yao Linxi Zeng Xin Huang Jinfang Zhang Guoqiang Zhang Ling Wang Source Type: research

[Retracted] Dexmedetomidine improves early postoperative neurocognitive disorder in elderly male patients undergoing thoracoscopic lobectomy
Exp Ther Med. 2024 Mar 19;27(5):204. doi: 10.3892/etm.2024.12492. eCollection 2024 May.ABSTRACT[This retracts the article DOI: 10.3892/etm.2020.9113.].PMID:38590558 | PMC:PMC11000070 | DOI:10.3892/etm.2024.12492 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Haixia Shi Xuejiang Du Fan Wu Yajuan Hu Zhipeng Xv Weidong Mi Source Type: research

Unusual clinical presentation of cervical extradural meningioma detected with neuromuscular ultrasound: A case report
Exp Ther Med. 2024 Mar 19;27(5):205. doi: 10.3892/etm.2024.12493. eCollection 2024 May.ABSTRACTExtradural meningiomas are rare in the cervical region. A total of 70-77% of reported cases have occurred in the thoracic region. Tumors that occur in the cervical region may invade the adjacent nerve root and brachial plexus. Typically, diagnoses of extradural meningioma are made after patients present with signs of myelopathy, such as progressive paresis and numbness. In the current study, a 64-year-old male patient presented with neck pain, numbness and mild weakness in the left hand over a 6-month period. The general neurolog...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Pei-Chen Hsieh Johnny Chuieng-Yi Lu Shih-Chiang Huang Cheng Hong Toh Hung-Chou Kuo Source Type: research

TRIM21 silencing inhibits the apoptosis and expedites the osteogenic differentiation of dexamethasone ‑induced MC3T3‑E1 cells by activating the Keap1/Nrf2 pathway
In conclusion, TRIM21 silencing might activate Keap1/Nrf2 signaling to protect against steroid-induced ONFH.PMID:38590560 | PMC:PMC11000457 | DOI:10.3892/etm.2024.12502 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Jiaqi Shi Li Chen Xu Wang Xin Ma Source Type: research

Transcriptome and proteome analyses reveal that upregulation of GSTM2 by allisartan improves cardiac remodeling and dysfunction in hypertensive rats
In conclusion, the present study demonstrated that allisartan can effectively control blood pressure in SHRs, and improves cardiac remodeling and cardiac dysfunction. Allisartan may also upregulate the expression levels of GSTM2 in the hearts of SHRs and significantly affect glutathione metabolism, as determined by transcriptome and proteome analyses. The cardioprotective effect of allisartan may be mediated through activation of the PI3K-AKT-Nrf2 signaling pathway, upregulation of GSTM2 expression and reduction of cardiomyocyte apoptosis in SHRs.PMID:38590561 | PMC:PMC11000455 | DOI:10.3892/etm.2024.12508 (Source: Experim...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Hao Wu Yajun Zhai Jing Yu Liping Wei Xin Qi Source Type: research

Apatinib beyond first progression is associated with prolonged overall survival in patients with advanced breast cancer: Results from an observational study
Exp Ther Med. 2024 Mar 14;27(5):200. doi: 10.3892/etm.2024.12488. eCollection 2024 May.ABSTRACTIn the present study, the efficacy and safety of a low dose of apatinib in the treatment of patients with advanced breast cancer (ABC) in a real-world setting were assessed, the impact of continuous anti-angiogenic therapy beyond progression was determined and the factors associated with efficacy were evaluated. A total of 63 patients with ABC who were treated with apatinib and for whom several lines of treatment had failed were retrospectively analyzed in Tangshan People's Hospital (Tangshan, China) between January 2016 and Octo...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Jing Wang Jinghao Jia Jingjing Liu Xuemin Yao Zhiyong Yuan Source Type: research

Exploring the molecular biology of ischemic cardiomyopathy based on ferroptosis ‑related genes
Exp Ther Med. 2024 Mar 22;27(5):221. doi: 10.3892/etm.2024.12509. eCollection 2024 May.ABSTRACTIschemic cardiomyopathy (ICM) is a serious cardiac disease with a very high mortality rate worldwide, which causes myocardial ischemia and hypoxia as the main damage. Further understanding of the underlying pathological processes of cardiomyocyte injury is key to the development of cardioprotective strategies. Ferroptosis is an iron-dependent form of regulated cell death characterized by the accumulation of lipid hydroperoxides to lethal levels, resulting in oxidative damage to the cell membrane. The current understanding of the ...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Shi-Tao Zhao Zhi-Cong Qiu Rui-Yuan Zeng Hua-Xi Zou Rong-Bin Qiu Han-Zhi Peng Lian-Fen Zhou Zhi-Qiang Xu Song-Qing Lai Li Wan Source Type: research

SLC38A2 promotes cell proliferation and invasion by promoting glutamine metabolism in adenomyosis
Exp Ther Med. 2024 Mar 21;27(5):218. doi: 10.3892/etm.2024.12506. eCollection 2024 May.ABSTRACTAdenomyosis is a benign uterine disorder that is associated with female infertility, a reduced clinical pregnancy rate and a high risk of miscarriage. Solute carrier family 38 member a2 (SLC38A2) is a glutamine (Gln) transporter that serves roles in various medical conditions. The present study aimed to reveal the role of SLC38A2 in adenomyosis. The mRNA expression levels of SLC38A2 in eutopic endometrial (EU) and ectopic endometrial (EC) tissues from adenomyotic patients were examined by reverse transcription-quantitative PCR. E...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Kui Wu Wei Gong Jia-Chang Hu Ying-Chun Duan Hui-Hui Ke Li Chen Source Type: research

Proteinase ‑3‑antineutrophil cytoplasmic antibody‑associated vasculitis secondary to subacute infective endocarditis: A case report
Exp Ther Med. 2024 Mar 20;27(5):216. doi: 10.3892/etm.2024.12504. eCollection 2024 May.ABSTRACTA 58-year-old male patient was admitted to Peking University First Hospital (Beijing, China) due to recurrent hematuria, proteinuria and kidney dysfunction. The patient was positive for proteinase-3 (PR3)-antineutrophil cytoplasmic antibody (ANCA). Pathology of the kidney showed focal proliferative necrotizing glomerulonephritis with crescent formation and immune complex-mediated glomerulonephritis. The patient was diagnosed with PR3-ANCA-associated vasculitis (AAV), received intensive immunosuppressive therapy and experienced tw...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Hui Lu Zhao Cui Xu-Jie Zhou Ying Yang Xiao-Ning Han Xi-Hui Li Fu-De Zhou Ming-Hui Zhao Source Type: research

Identification of common genes of rhinovirus single/double ‑stranded RNA‑induced asthma deterioration by bioinformatics analysis
Exp Ther Med. 2024 Mar 20;27(5):210. doi: 10.3892/etm.2024.12498. eCollection 2024 May.ABSTRACTRhinovirus (RV) is the most common respiratory virus affecting humans. The majority of asthma deteriorations are triggered by RV infections. However, whether the effects of RV single- and double-stranded RNA on asthma deterioration have common target genes needs to be further studied. In the present study, two datasets (GSE51392 and GSE30326) were used to screen for common differentially expressed genes (cDEGs). The molecular function, signaling pathways, interaction networks, hub genes, key modules and regulatory molecules of cD...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Qian An Yi Cao Wei Guo Ziyun Jiang Hui Luo Hui Liu Xiaodong Zhan Source Type: research

A study of the molecular mechanism of action of Jiawei Guizhishaoyaozhimu Decoction during rheumatoid arthritis therapy based on basic of network pharmacology and experimental verification
Exp Ther Med. 2024 Mar 20;27(5):212. doi: 10.3892/etm.2024.12499. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is a chronic autoimmune disease, which primarily affects the joints. The aim of the present study was to predict the main active ingredients of Jiawei Guizhishaoyaozhimu Decoction (JWGZSYZMD) and potential targets of this treatment during RA therapy by using molecular docking and network pharmacology methods. In addition, another aim was to investigate the therapeutic effects and mechanism of JWGZSYZMD on joint inflammation in rat models of collagen Ⅱ-induced arthritis (CIA). JWGZSYZMD ingredients and ...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yiji Cheng Yue Ji Kaidi Feng Xinyuan Zhang Yunming Xiao Weixia Jing Source Type: research

Recent development of oral vaccines (Review)
Exp Ther Med. 2024 Mar 22;27(5):223. doi: 10.3892/etm.2024.12511. eCollection 2024 May.ABSTRACTOral immunization can elicit an effective immune response and immune tolerance to specific antigens. When compared with the traditional injection route, delivering antigens via the gastrointestinal mucosa offers superior immune effects and compliance, as well as simplicity and convenience, making it a more optimal route for immunization. At present, various oral vaccine delivery systems exist. Certain modified bacteria, such as Salmonella, Escherichia coli and particularly Lactobacillus, are considered promising carriers for oral...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Ying Liu Dominic Man-Kit Lam Mei Luan Wenfu Zheng Hao Ai Source Type: research

Effects of total saikosaponins on CYP3A4 and CYP1A2 in HepaRG cells
Exp Ther Med. 2024 Mar 21;27(5):217. doi: 10.3892/etm.2024.12505. eCollection 2024 May.ABSTRACTTotal saikosaponins (TSS) form a group of chemically and biologically active components that can be extracted from Bupleurum, with reported antidepressive, anti-inflammatory, antiviral, antiendotoxin, antitumor, anti-pulmonary fibrosis and anti-gastric ulcer effects. Bupleurum or TSS is frequently utilized in clinical practice alongside other medications (such as entecavir, lamivudine, compound paracetamol and amantadine hydrochloride capsules), leading to an increased risk of drug-drug interactions. The cytochrome P450 (CYP) fam...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yunyan Tang Hongfang Li Jianhua Tang Lei Hu Feifei Ma Yanmiao Liu Fushan Tang Source Type: research

Vigeo attenuates cartilage and bone destruction in a collagen ‑induced arthritis mouse model by reducing production of pro‑inflammatory cytokines
Exp Ther Med. 2024 Mar 19;27(5):208. doi: 10.3892/etm.2024.12496. eCollection 2024 May.ABSTRACTRheumatoid arthritis (RA) is an autoimmune and chronic inflammatory disease characterized by articular cartilage destruction, bone destruction and synovial hyperplasia. It has been suggested that Vigeo, a mixture of Eleutherococcus senticosus, Achyranthes japonica and Atractylodes japonica fermented with Korean nuruk, has an anti-osteoporotic effect in a mouse model of inflammation-mediated bone loss. The present study evaluated the therapeutic effects of Vigeo in RA using a collagen-induced arthritis (CIA) mouse model. DBA/1J mi...
Source: Experimental and Therapeutic Medicine - April 9, 2024 Category: General Medicine Authors: Yoon-Hee Cheon Chang Hoon Lee So Young Eun Gyeong Do Park Chong Hyuk Chung Ju-Young Kim Myeung Su Lee Source Type: research