Mesenchymal stem cells derived from CHIR99021 and TGF ‑β induction remained on the colicomentum and improved cardiac function of a rat model of acute myocardium infarction

In conclusion, the CHIR99021 and TGF-β combined induction was a rapid and effective method to obtain MSC-like cells from hiPSCs and multiple high dose intraperitoneal injections of hiPSC-derived MSCs were safe and effective at restoring cardiac function in an AMI rat model.PMID:38515646 | PMC:PMC10952379 | DOI:10.3892/etm.2024.12470

Source: Experimental and Therapeutic Medicine - March 22, 2024 Category: General Medicine Authors: Yusen Zhang Yanmin Zhang Azhen Hu Fanhua Meng Peng Cui Tianshi Li Guanghui Cui Source Type: research