S100 calcium ‑binding protein A16 suppresses the osteogenic differentiation of rat bone marrow mesenchymal stem cells by inhibiting SMAD family member 4 signaling
Exp Ther Med. 2024 Apr 15;27(6):250. doi: 10.3892/etm.2024.12538. eCollection 2024 Jun.ABSTRACTOsteogenesis is a complex process of bone formation regulated by various factors, yet its underlying molecular mechanisms remain incompletely understood. The present study aimed to investigate the role of S100A16, a novel member of the S100 protein family, in the osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) and uncover a novel Smad4-mitogen-activated protein kinase (MAPK)/Jun N-terminal kinase (JNK) signaling axis. In the present study, the expression level of S100A16 in bone tissues and BMSCs from...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Jing Xin Zhaoxu Wang Yanju Shen Jing Bai Yafei Shen Source Type: research

Antioxidant and anti ‑inflammatory effects of esculin and esculetin (Review)
Exp Ther Med. 2024 Apr 12;27(6):248. doi: 10.3892/etm.2024.12536. eCollection 2024 Jun.ABSTRACTFraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin. The aim of the present study was to systematically review relevant literature on the antioxidant and anti-inflammatory effects of esculetin and esculin. Esculetin and esculin can promote the ex...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Shaohua Ju Youli Tan Qiang Wang Ling Zhou Kun Wang Chenghong Wen Mingjian Wang Source Type: research

[Retracted] Reduced miR ‑202 levels enhanced oral cancer development via targeting Sp1
Exp Ther Med. 2024 Apr 15;27(6):251. doi: 10.3892/etm.2024.12539. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/etm.2019.7603.].PMID:38682115 | PMC:PMC11046176 | DOI:10.3892/etm.2024.12539 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Jia Zhao Deguang Ding Ge Zhao Source Type: research

Preparation and evaluation of the PD0721 ‑DOX antibody‑drug conjugate targeting EGFRvIII to inhibit glioblastoma
Exp Ther Med. 2024 Apr 17;27(6):254. doi: 10.3892/etm.2024.12542. eCollection 2024 Jun.ABSTRACTEpidermal growth factor receptor variant III (EGFRvIII) is prominently expressed in various epithelial tumors. PD0721, a single-chain antibody (scFv), has been developed to specifically target EGFRvIII. Although doxorubicin (DOX) is an essential treatment approach for glioblastoma (GBM), its toxic effects and limited targeting capabilities are a challenge. To overcome the above limitations, antibody-drug conjugates (ADCs) have been developed to exploit the specificity of monoclonal antibodies in directing potent cytotoxic drugs t...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Minmin Hu Hong Liu Yubing Zhang Dingyan Lu Lin Zheng Yonglin Wang Shuaishuai Chen Ting Liu Source Type: research

Vastus lateralis flap for trochanteric sarcoma reconstruction following prior main pedicle dissection: A case report
Exp Ther Med. 2024 Apr 12;27(6):249. doi: 10.3892/etm.2024.12537. eCollection 2024 Jun.ABSTRACTThe reconstruction of trochanteric defects presents a challenge to the reconstructive surgeon. There have been a number of locoregional reconstructive options described in the literature. These include flaps based on the lateral circumflex femoral artery and its branches, such as the tensor fascia lata, vastus lateralis (VL), anterolateral thigh (ALT) flaps. The present case further complicated this challenge as the patient had multiple recurrences of a sarcoma overlying the trochanteric region, with previous surgical resections,...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Zahir T Fadel Amani J Basaeed Mohammed B Ashi Hattan A Aljaaly Source Type: research

Erratum: [Corrigendum] Hydrogen gas post ‑conditioning alleviates cognitive dysfunction and anxiety‑like behavior in a rat model of subarachnoid hemorrhage
Exp Ther Med. 2024 Apr 17;27(6):253. doi: 10.3892/etm.2024.12541. eCollection 2024 Jun.ABSTRACT[This corrects the article DOI: 10.3892/etm.2021.10555.].PMID:38682110 | PMC:PMC11046182 | DOI:10.3892/etm.2024.12541 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Jing-Hua Song Hong-Yan Jia Tian-Peng Shao Zhi-Bao Liu Yuan-Ping Zhao Source Type: research

YTHDF1 regulates immune cell infiltration in gastric cancer via interaction with p53
In conclusion, the findings of the present study indicate that YTHDF1 is associated with a poor prognosis and serves an important role in the TME of GC. We hypothesize, for the first time to the best of our knowledge, that YTHDF1 regulates immune cell infiltration by interacting with p53 in GC, which provides a promising direction for future research.PMID:38682111 | PMC:PMC11046265 | DOI:10.3892/etm.2024.12543 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Quan Liao Jianping Xiong Source Type: research

GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1 ‑autophagy axis
In conclusion, GDF11 may exert tumor-suppressive properties in HCC cells through inactivating the mTORC1 signaling pathway to strengthen autophagy.PMID:38682112 | PMC:PMC11046183 | DOI:10.3892/etm.2024.12540 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Qingyi Wu Chan Fan Kebo Liu Jiefu Tang Source Type: research

S100 calcium ‑binding protein A16 suppresses the osteogenic differentiation of rat bone marrow mesenchymal stem cells by inhibiting SMAD family member 4 signaling
Exp Ther Med. 2024 Apr 15;27(6):250. doi: 10.3892/etm.2024.12538. eCollection 2024 Jun.ABSTRACTOsteogenesis is a complex process of bone formation regulated by various factors, yet its underlying molecular mechanisms remain incompletely understood. The present study aimed to investigate the role of S100A16, a novel member of the S100 protein family, in the osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMSCs) and uncover a novel Smad4-mitogen-activated protein kinase (MAPK)/Jun N-terminal kinase (JNK) signaling axis. In the present study, the expression level of S100A16 in bone tissues and BMSCs from...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Jing Xin Zhaoxu Wang Yanju Shen Jing Bai Yafei Shen Source Type: research

Antioxidant and anti ‑inflammatory effects of esculin and esculetin (Review)
Exp Ther Med. 2024 Apr 12;27(6):248. doi: 10.3892/etm.2024.12536. eCollection 2024 Jun.ABSTRACTFraxinus chinensis Roxb is a deciduous tree, which is distributed worldwide and has important medicinal value. In Asia, the bark of Fraxinus chinensis Roxb is a commonly used traditional Chinese medicine called Qinpi. Esculetin is a coumarin compound derived from the bark of Fraxinus chinensis Roxb and its glycoside form is called esculin. The aim of the present study was to systematically review relevant literature on the antioxidant and anti-inflammatory effects of esculetin and esculin. Esculetin and esculin can promote the ex...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Shaohua Ju Youli Tan Qiang Wang Ling Zhou Kun Wang Chenghong Wen Mingjian Wang Source Type: research

[Retracted] Reduced miR ‑202 levels enhanced oral cancer development via targeting Sp1
Exp Ther Med. 2024 Apr 15;27(6):251. doi: 10.3892/etm.2024.12539. eCollection 2024 Jun.ABSTRACT[This retracts the article DOI: 10.3892/etm.2019.7603.].PMID:38682115 | PMC:PMC11046176 | DOI:10.3892/etm.2024.12539 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Jia Zhao Deguang Ding Ge Zhao Source Type: research

Preparation and evaluation of the PD0721 ‑DOX antibody‑drug conjugate targeting EGFRvIII to inhibit glioblastoma
Exp Ther Med. 2024 Apr 17;27(6):254. doi: 10.3892/etm.2024.12542. eCollection 2024 Jun.ABSTRACTEpidermal growth factor receptor variant III (EGFRvIII) is prominently expressed in various epithelial tumors. PD0721, a single-chain antibody (scFv), has been developed to specifically target EGFRvIII. Although doxorubicin (DOX) is an essential treatment approach for glioblastoma (GBM), its toxic effects and limited targeting capabilities are a challenge. To overcome the above limitations, antibody-drug conjugates (ADCs) have been developed to exploit the specificity of monoclonal antibodies in directing potent cytotoxic drugs t...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Minmin Hu Hong Liu Yubing Zhang Dingyan Lu Lin Zheng Yonglin Wang Shuaishuai Chen Ting Liu Source Type: research

Vastus lateralis flap for trochanteric sarcoma reconstruction following prior main pedicle dissection: A case report
Exp Ther Med. 2024 Apr 12;27(6):249. doi: 10.3892/etm.2024.12537. eCollection 2024 Jun.ABSTRACTThe reconstruction of trochanteric defects presents a challenge to the reconstructive surgeon. There have been a number of locoregional reconstructive options described in the literature. These include flaps based on the lateral circumflex femoral artery and its branches, such as the tensor fascia lata, vastus lateralis (VL), anterolateral thigh (ALT) flaps. The present case further complicated this challenge as the patient had multiple recurrences of a sarcoma overlying the trochanteric region, with previous surgical resections,...
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Zahir T Fadel Amani J Basaeed Mohammed B Ashi Hattan A Aljaaly Source Type: research

Erratum: [Corrigendum] Hydrogen gas post ‑conditioning alleviates cognitive dysfunction and anxiety‑like behavior in a rat model of subarachnoid hemorrhage
Exp Ther Med. 2024 Apr 17;27(6):253. doi: 10.3892/etm.2024.12541. eCollection 2024 Jun.ABSTRACT[This corrects the article DOI: 10.3892/etm.2021.10555.].PMID:38682110 | PMC:PMC11046182 | DOI:10.3892/etm.2024.12541 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Jing-Hua Song Hong-Yan Jia Tian-Peng Shao Zhi-Bao Liu Yuan-Ping Zhao Source Type: research

YTHDF1 regulates immune cell infiltration in gastric cancer via interaction with p53
In conclusion, the findings of the present study indicate that YTHDF1 is associated with a poor prognosis and serves an important role in the TME of GC. We hypothesize, for the first time to the best of our knowledge, that YTHDF1 regulates immune cell infiltration by interacting with p53 in GC, which provides a promising direction for future research.PMID:38682111 | PMC:PMC11046265 | DOI:10.3892/etm.2024.12543 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 29, 2024 Category: General Medicine Authors: Quan Liao Jianping Xiong Source Type: research