Apelin ‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress
In conclusion, the present study elucidated the protective role of Apelin-13 in ameliorating HG-induced mitochondrial functional impairment in cochlear hair cells by inhibiting ER stress.PMID:38596659 | PMC:PMC11002831 | DOI:10.3892/etm.2024.12515 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Zhiqiang Huo Jun Gu Teng He Source Type: research

Current clinical application of lutetium ‑177 in solid tumors (Review)
Exp Ther Med. 2024 Mar 26;27(5):225. doi: 10.3892/etm.2024.12514. eCollection 2024 May.ABSTRACTRadionuclide-based therapy represents a novel treatment regimen for tumors. Among these therapies, lutetium-177 (177Lu) has gained significant attention due to its stability and safety, as well as its ability to emit both γ and β rays, allowing for both imaging with single photon emission computed tomography and tumor treatment. As a result, 177Lu can be used for both diagnosis and treatment for diseases such as prostatic and gastric cancer. Therefore, based on the available data, the present review provides a brief overview of...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Tingting Niu Mi Fan Binwei Lin Feng Gao Bangxian Tan Xiaobo Du Source Type: research

Bulk and single cells transcriptomes with experimental validation identify USP18 as a novel glioma prognosis and proliferation indicator
In conclusion, the present study demonstrated that knockdown of USP18 expression inhibited the proliferation of glioma cells, which may be mediated by the effect of USP18 on the IFN-I response.PMID:38596661 | PMC:PMC11002833 | DOI:10.3892/etm.2024.12517 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Yang Chen Ren Li Ziao Li Biao Yang Jianhang He Jiayu Li Peize Li Zihan Zhou Yongqiang Wu Yuanli Zhao Geng Guo Source Type: research

[Retracted] Anthelmintic drug albendazole arrests human gastric cancer cells at the mitotic phase and induces apoptosis
Exp Ther Med. 2024 Mar 26;27(5):227. doi: 10.3892/etm.2024.12513. eCollection 2024 May.ABSTRACT[This retracts the article DOI: 10.3892/etm.2016.3992.].PMID:38596655 | PMC:PMC11002832 | DOI:10.3892/etm.2024.12513 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Xuan Zhang Jing Zhao Xiangyang Gao Dongsheng Pei Chao Gao Source Type: research

Control of pleural effusion with prednisolone in a patient with yellow nail syndrome: A case report
Exp Ther Med. 2024 Mar 22;27(5):224. doi: 10.3892/etm.2024.12512. eCollection 2024 May.ABSTRACTYellow nail syndrome (YNS) can induce bilateral exudative pleural effusion; however, to the best of our knowledge, no standard treatment for YNS has been established. The present study describes a patient with YNS for whom the pleural effusion was controlled by prednisolone. A 73-year-old man was referred to the University of Tsukuba Hospital (Ibaraki, Japan) complaining of shortness of breath, which was diagnosed as being due to bilateral pleural effusion. Based on the presence of yellowing and growth retardation of the toenails...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Manato Taguchi Hironori Masuko Kai Kawashima Tetsuya Yamagishi Yuka Kitaoka Rie Shigemasa Kazufumi Yoshida Chikako Tsurushige Hiroaki Satoh Nobuyuki Hizawa Source Type: research

Non ‑contact locking plate: A useful alternative to external fixation in second‑stage treatment of post‑traumatic tibial osteomyelitis
In conclusion, the results of the present study demonstrate that the non-contact locking plate technique provided stable fixation without any contact between the implant and bone tissues. Therefore, this technique may be viable for use during the reconstruction stage of post-traumatic tibial osteomyelitis.PMID:38596657 | PMC:PMC11002822 | DOI:10.3892/etm.2024.12518 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Yan Zhu Peng Jiang Zhiwei He Hongbo Qian Source Type: research

Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease
Exp Ther Med. 2024 Mar 26;27(5):228. doi: 10.3892/etm.2024.12516. eCollection 2024 May.ABSTRACTGlucose transporter isoform 1 (GLUT1), which is upregulated in a variety of malignant tumors, facilitates cellular glucose uptake to boost rapid tumor growth and progression. In several types of cancer, inhibition of GLUT1 suppresses tumor proliferation and metastasis, indicating that GLUT1 is a potential target of anticancer therapy. The present study performed immunohistochemistry to analyze GLUT1 expression levels in 51 patients with extramammary Paget's disease (EMPD), including 23 with only intraepidermal lesions and 28 with...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Mika Matsumoto Daiki Rokunohe Takanori Sasaki Yasushi Matsuzaki Hajime Nakano Hiroki Mizukami Eijiro Akasaka Daisuke Sawamura Source Type: research

Apelin ‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress
In conclusion, the present study elucidated the protective role of Apelin-13 in ameliorating HG-induced mitochondrial functional impairment in cochlear hair cells by inhibiting ER stress.PMID:38596659 | PMC:PMC11002831 | DOI:10.3892/etm.2024.12515 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Zhiqiang Huo Jun Gu Teng He Source Type: research

Current clinical application of lutetium ‑177 in solid tumors (Review)
Exp Ther Med. 2024 Mar 26;27(5):225. doi: 10.3892/etm.2024.12514. eCollection 2024 May.ABSTRACTRadionuclide-based therapy represents a novel treatment regimen for tumors. Among these therapies, lutetium-177 (177Lu) has gained significant attention due to its stability and safety, as well as its ability to emit both γ and β rays, allowing for both imaging with single photon emission computed tomography and tumor treatment. As a result, 177Lu can be used for both diagnosis and treatment for diseases such as prostatic and gastric cancer. Therefore, based on the available data, the present review provides a brief overview of...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Tingting Niu Mi Fan Binwei Lin Feng Gao Bangxian Tan Xiaobo Du Source Type: research

Bulk and single cells transcriptomes with experimental validation identify USP18 as a novel glioma prognosis and proliferation indicator
In conclusion, the present study demonstrated that knockdown of USP18 expression inhibited the proliferation of glioma cells, which may be mediated by the effect of USP18 on the IFN-I response.PMID:38596661 | PMC:PMC11002833 | DOI:10.3892/etm.2024.12517 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Yang Chen Ren Li Ziao Li Biao Yang Jianhang He Jiayu Li Peize Li Zihan Zhou Yongqiang Wu Yuanli Zhao Geng Guo Source Type: research

[Retracted] Anthelmintic drug albendazole arrests human gastric cancer cells at the mitotic phase and induces apoptosis
Exp Ther Med. 2024 Mar 26;27(5):227. doi: 10.3892/etm.2024.12513. eCollection 2024 May.ABSTRACT[This retracts the article DOI: 10.3892/etm.2016.3992.].PMID:38596655 | PMC:PMC11002832 | DOI:10.3892/etm.2024.12513 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Xuan Zhang Jing Zhao Xiangyang Gao Dongsheng Pei Chao Gao Source Type: research

Control of pleural effusion with prednisolone in a patient with yellow nail syndrome: A case report
Exp Ther Med. 2024 Mar 22;27(5):224. doi: 10.3892/etm.2024.12512. eCollection 2024 May.ABSTRACTYellow nail syndrome (YNS) can induce bilateral exudative pleural effusion; however, to the best of our knowledge, no standard treatment for YNS has been established. The present study describes a patient with YNS for whom the pleural effusion was controlled by prednisolone. A 73-year-old man was referred to the University of Tsukuba Hospital (Ibaraki, Japan) complaining of shortness of breath, which was diagnosed as being due to bilateral pleural effusion. Based on the presence of yellowing and growth retardation of the toenails...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Manato Taguchi Hironori Masuko Kai Kawashima Tetsuya Yamagishi Yuka Kitaoka Rie Shigemasa Kazufumi Yoshida Chikako Tsurushige Hiroaki Satoh Nobuyuki Hizawa Source Type: research

Non ‑contact locking plate: A useful alternative to external fixation in second‑stage treatment of post‑traumatic tibial osteomyelitis
In conclusion, the results of the present study demonstrate that the non-contact locking plate technique provided stable fixation without any contact between the implant and bone tissues. Therefore, this technique may be viable for use during the reconstruction stage of post-traumatic tibial osteomyelitis.PMID:38596657 | PMC:PMC11002822 | DOI:10.3892/etm.2024.12518 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Yan Zhu Peng Jiang Zhiwei He Hongbo Qian Source Type: research

Upregulated expression of glucose transporter isoform 1 in invasive and metastatic extramammary Paget's disease
Exp Ther Med. 2024 Mar 26;27(5):228. doi: 10.3892/etm.2024.12516. eCollection 2024 May.ABSTRACTGlucose transporter isoform 1 (GLUT1), which is upregulated in a variety of malignant tumors, facilitates cellular glucose uptake to boost rapid tumor growth and progression. In several types of cancer, inhibition of GLUT1 suppresses tumor proliferation and metastasis, indicating that GLUT1 is a potential target of anticancer therapy. The present study performed immunohistochemistry to analyze GLUT1 expression levels in 51 patients with extramammary Paget's disease (EMPD), including 23 with only intraepidermal lesions and 28 with...
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Mika Matsumoto Daiki Rokunohe Takanori Sasaki Yasushi Matsuzaki Hajime Nakano Hiroki Mizukami Eijiro Akasaka Daisuke Sawamura Source Type: research

Apelin ‑13 reduces high glucose‑induced mitochondrial dysfunction in cochlear hair cells by inhibiting endoplasmic reticulum stress
In conclusion, the present study elucidated the protective role of Apelin-13 in ameliorating HG-induced mitochondrial functional impairment in cochlear hair cells by inhibiting ER stress.PMID:38596659 | PMC:PMC11002831 | DOI:10.3892/etm.2024.12515 (Source: Experimental and Therapeutic Medicine)
Source: Experimental and Therapeutic Medicine - April 10, 2024 Category: General Medicine Authors: Zhiqiang Huo Jun Gu Teng He Source Type: research