Paeoniflorigenone inhibits ovarian cancer metastasis through targeting the MUC1/Wnt/ β‑catenin pathway
In conclusion, the present study demonstrated that PFG may inhibit the MUC1/Wnt/β‑catenin pathway to induce anti‑metastatic, anti‑invasive and anti‑EMT effects on OC. Notably, MUC1 may be a direct target of PFG. Thus, PFG holds promise as a specific antitumor agent for the treatment of OC.PMID:38785138 | DOI:10.3892/ijmm.2024.5384 (Source: Molecular Medicine)
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Qingling Liu Liqin Jiang Yun Zhao Fang Su Junfeng Li Xinxin Tian Wenhong Liu Xiawei Jiang Ye Xu Fangfang Tao Source Type: research

Astragaloside IV protects against autoimmune myasthenia gravis in rats via regulation of mitophagy and apoptosis
In conclusion, AS‑IV may protect against EAMG in a rat model by modulating mitophagy and apoptosis. These findings indicated the potential mechanism underlying the effects of AS‑IV on MG and provided novel insights into treatment strategies for MG.PMID:38785143 | DOI:10.3892/mmr.2024.13253 (Source: Molecular Medicine)
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Jingjing Zhang Jiayan Huang Jinlian Lan Qing Li Lingling Ke Qilong Jiang Yanwu Li Han Zhang Huiya Zhong Peidan Yang Tongkai Chen Yafang Song Source Type: research

< em > Saururus chinensis < /em > (Lour.) Baill. extract promotes skeletal muscle cell differentiation by positively regulating mitochondrial biogenesis and AKT/mTOR signaling < em > in vitro < /em >
Mol Med Rep. 2024 Jul;30(1):125. doi: 10.3892/mmr.2024.13250. Epub 2024 May 24.ABSTRACTPromotion of myoblast differentiation by activating mitochondrial biogenesis and protein synthesis signaling pathways provides a potential alternative strategy to balance energy and overcome muscle loss and muscle disorders. Saururus chinensis (Lour.) Baill. extract (SCE) has been used extensively as a traditional herbal medicine and has several physiological activities, including anti‑asthmatic, anti‑oxidant, anti‑inflammatory, anti‑atopic, anticancer and hepatoprotective properties. However, the effects and mechanisms of action...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: So Young Eun Chong Hyuk Chung Yoon-Hee Cheon Gyeong Do Park Chang Hoon Lee Ju-Young Kim Myeung Su Lee Source Type: research

Oroxylin A inhibits inflammatory cytokines in periodontitis via HO ‑1
Mol Med Rep. 2024 Jul;30(1):126. doi: 10.3892/mmr.2024.13249. Epub 2024 May 24.ABSTRACTPeriodontal disease is a common infectious disease that can lead to the loss of teeth. Hower how to effectively suppress the inflammation with medication is unclear. The aim of the present study was to investigate the anti‑inflammatory effect of Oroxylin A in periodontitis and its potential role through heme oxygenase‑1 (HO‑1). Primary rat gingival fibroblasts (RGFs) were cultured using the tissue block method and identified by immunofluorescence. Following lipopolysaccharide (LPS) stimulation of RGFs, Oroxylin A was administered ...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Ting Wang Zhao-Bo Wang Chun-Miao Jiang Yang Zhao Li Tang Xi-Mei Xiao Jing Fu Source Type: research

Association of gut dysbiosis with first ‑episode psychosis (Review)
Mol Med Rep. 2024 Jul;30(1):130. doi: 10.3892/mmr.2024.13254. Epub 2024 May 24.ABSTRACTThe gut‑microbiota‑brain axis is a complex bidirectional communication system linking the gastrointestinal tract to the brain. Changes in the balance, composition and diversity of the gut‑microbiota (gut dysbiosis) have been found to be associated with the development of psychosis. Early‑life stress, along with various stressors encountered in different developmental phases, have been shown to be associated with the abnormal composition of the gut microbiota, leading to irregular immunological and neuroendocrine functions, which ...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Christos Theleritis Maria-Ioanna Stefanou Marina Demetriou Evangelos Alevyzakis Konstantinos Triantafyllou Nikolaos Smyrnis Demetrios A Spandidos Emmanouil Rizos Source Type: research

Estrogen inhibits TGF ‑β1‑stimulated cardiac fibroblast differentiation and collagen synthesis by promoting Cdc42
Mol Med Rep. 2024 Jul;30(1):123. doi: 10.3892/mmr.2024.13246. Epub 2024 May 24.ABSTRACT17β‑estradiol (E2) can inhibit cardiac fibrosis in female patients with heart failure (HF) and activate cell division cycle 42 (Cdc42), however it is unknown whether 17β‑estradiol (E2) can ameliorate differentiation and collagen synthesis in TGF‑β1‑stimulated mouse cardiac fibroblasts (MCFs) by regulating cell division cycle 42 (Cdc42). The present study aimed to investigate the roles of estrogen and Cdc42 in preventing myocardial fibrosis and the underlying molecular mechanisms. An ELISA was used to measure the levels of E2 a...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Jingyi Xu Feng Wang Yuan Li Ping Li Yiqing Zhang Guidong Xu Kangyun Sun Ying Huang Source Type: research

Possible association of G6PC2 and MUC6 induced by low ‑dose‑rate irradiation in mouse intestine with inflammatory bowel disease
Mol Med Rep. 2024 Jul;30(1):127. doi: 10.3892/mmr.2024.13251. Epub 2024 May 24.ABSTRACTAlthough there are several types of radiation exposure, it is debated whether low‑dose‑rate (LDR) irradiation (IR) affects the body. Since the small intestine is a radiation‑sensitive organ, the present study aimed to evaluate how it changes when exposed to LDR IR and identify the genes sensitive to these doses. After undergoing LDR (6.0 mGy/h) γ radiation exposure, intestinal RNA from BALB/c mice was extracted 1 and 24 h later. Mouse whole genome microarrays were used to explore radiation‑induced transcriptional alterations. Re...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Sohi Kang Min Ji Bae Min Kook Kang Hyojin Kim Yeong-Rok Kang Wol Soon Jo Chang Geun Lee Bokyung Jung Jeongmin Lee Changjong Moon Yeonghoon Son Hae-June Lee Joong Sun Kim Source Type: research

[Retracted] MicroRNA ‑584 prohibits hepatocellular carcinoma cell proliferation and invasion by directly targeting BDNF
Mol Med Rep. 2024 Jul;30(1):124. doi: 10.3892/mmr.2024.13248. Epub 2024 May 24.ABSTRACTFollowing the publication of this paper, it was drawn to the Editor's attention by a concerned reader that the Transwell invasion assay data shown in Fig. 2C and D on p. 1997 were strikingly similar to data appearing in different form in other articles written by different authors at different research institutes that had either already been published, or were submitted for publication at around the same time (and in some cases, have subsequently been retracted). Owing to the fact that the contentious data in the above article had alread...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Yanan Song Guoyu Wang Juhua Zhuang Jing Ni Suiliang Zhang Ying Ye Wei Xia Source Type: research

Tributyltin chloride induces chondrocyte damage through the activation of NLRP3 ‑mediated inflammation and pyroptosis
In conclusion, TBTC may aggravate OA in mice by promoting chondrocyte damage and inducing pyroptosis through the activation of NLRP3 and caspase‑1 signaling. The present study demonstrated that TBTC can cause significant damage to the articular cartilage; therefore, TBTC contamination should be strictly monitored.PMID:38785157 | DOI:10.3892/mmr.2024.13247 (Source: Molecular Medicine)
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Silong Xia Rong Ma Source Type: research

Recent advances in potential therapeutic targets of ferroptosis ‑associated pathways for the treatment of stroke (Review)
In conclusion, the present review provides a comprehensive overview of the potential therapeutic targets afforded by ferroptosis‑associated pathways in stroke, offering new insights into how ferroptosis may be exploited in the treatment of stroke.PMID:38785160 | DOI:10.3892/mmr.2024.13252 (Source: Molecular Medicine)
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Hao Dong Ya-Ping Ma Mei-Mei Cui Zheng-Hao Qiu Mao-Tao He Bao-Gang Zhang Source Type: research

Role of lactate and lactate metabolism in liver diseases (Review)
Int J Mol Med. 2024 Jul;54(1):59. doi: 10.3892/ijmm.2024.5383. Epub 2024 May 24.ABSTRACTLactate is a byproduct of glycolysis, and before the Warburg effect was revealed (in which glucose can be fermented in the presence of oxygen to produce lactate) it was considered a metabolic waste product. At present, lactate is not only recognized as a metabolic substrate that provides energy, but also as a signaling molecule that regulates cellular functions under pathophysiological conditions. Lactylation, a post‑translational modification, is involved in the development of various diseases, including inflammation and tumors. Live...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Shun Yao Hongyu Chai Ting Tao Li Zhang Xingyue Yang Xin Li Zhiqiang Yi Yongfeng Wang Jiaxin An Guorong Wen Hai Jin Biguang Tuo Source Type: research

NR1D1-transactivated lncRNA NUTM2A-AS1 promotes chemoresistance and immune evasion in neuroblastoma via inhibiting B7-H3 degradation
J Cell Mol Med. 2024 May;28(10):e18360. doi: 10.1111/jcmm.18360.ABSTRACTNeuroblastoma (NB), a common solid tumour in young children originating from the sympathetic nervous system during embryonic development, poses challenges despite therapeutic advances like high-dose chemotherapy and immunotherapy. Some survivors still grapple with severe side effects and drug resistance. The role of lncRNA NUTM2A-AS1 has been explored in various cancers, but its function in drug-resistant NB progression is unclear. Our study found that NUTM2A-AS1 expression in cisplatin-resistant NB cells increased in a time- and dose-dependent manner....
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Tian Xiang Yejing Li Gao Liu Xianyun Li Source Type: research

Identification of biomarkers for abdominal aortic aneurysm in Beh çet's disease via mendelian randomization and integrated bioinformatics analyses
J Cell Mol Med. 2024 May;28(10):e18398. doi: 10.1111/jcmm.18398.ABSTRACTBehçet's disease (BD) is a complex autoimmune disorder impacting several organ systems. Although the involvement of abdominal aortic aneurysm (AAA) in BD is rare, it can be associated with severe consequences. In the present study, we identified diagnostic biomarkers in patients with BD having AAA. Mendelian randomization (MR) analysis was initially used to explore the potential causal association between BD and AAA. The Limma package, WGCNA, PPI and machine learning algorithms were employed to identify potential diagnostic genes. A receiver operating...
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Chunjiang Liu Huadong Wu Kuan Li Yongxing Chi Zhaoying Wu Chungen Xing Source Type: research

Why and how optical molecular imaging should further be catalyzed by nuclear medicine and molecular imaging: report from the EANM piloting group
Eur J Nucl Med Mol Imaging. 2024 May 24. doi: 10.1007/s00259-024-06729-3. Online ahead of print.NO ABSTRACTPMID:38787394 | DOI:10.1007/s00259-024-06729-3 (Source: Molecular Medicine)
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: J Vonk R A J O Dierckx S Keereweer A L Vahrmeijer F A Verburg S Kruijff Source Type: research

Development and evaluation of albumin binder-conjugated heterodimeric radiopharmaceuticals targeting integrin α < sub > v < /sub > β < sub > 3 < /sub > and CD13 for cancer therapy
CONCLUSION: A new integrin αvβ3 and CD13 targeting compound was screened out. This compound bears a novel albumin binder and exhibits increased tumor uptake and prolonged tumor retention in BxPC-3 tumors and low background in normal organs, making it a perfect candidate for radiotherapy when radiolabeled with 177Lu.PMID:38787395 | DOI:10.1007/s00259-024-06766-y (Source: Molecular Medicine)
Source: Molecular Medicine - May 24, 2024 Category: Molecular Biology Authors: Biao Yang Changyu Shan Xiangming Song Xiaoying Lv Yu Long Dexing Zeng Rui An Xiaoli Lan Yongkang Gai Source Type: research