Contribution of ChatGPT in Parkinson's Disease Detection
Nucl Med Mol Imaging. 2024 May;58(3):101-103. doi: 10.1007/s13139-024-00857-2. Epub 2024 Mar 15.NO ABSTRACTPMID:38633283 | PMC:PMC11018720 | DOI:10.1007/s13139-024-00857-2 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Nikita Aggarwal Barjinder Singh Saini Savita Gupta Source Type: research
Association Between < sup > 18 < /sup > F-FDG PET Activity and HER2 Status in Breast Cancer Brain Metastases
CONCLUSION: The SUVmax ratio may help to identify the HER2 status of breast cancer brain metastases, if validated prospectively.PMID:38633284 | PMC:PMC11018722 | DOI:10.1007/s13139-024-00843-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Jonathan R Young Julie A Ressler Joanne E Mortimer Daniel Schmolze Mariko Fitzgibbons Bihong T Chen Source Type: research
Annotating the Role of < sup > 18 < /sup > F-FDG PET/CT in Fibromatoses: A Benign Masquerader of Malignancies-Is It Really an Advantageous Tool?
Nucl Med Mol Imaging. 2024 May;58(3):140-146. doi: 10.1007/s13139-024-00846-5. Epub 2024 Feb 14.ABSTRACTFibromatoses are a heterogeneous group of benign proliferating fibroblasts and myofibroblasts which have a high predilection for recurrence and local invasion, especially deep fibromatoses or desmoid fibromatosis. 18F-FDG PET/CT, the workhorse of oncological imaging in nuclear medicine, can be employed to figure out the nature and aggressiveness of the lesions and various sites of involvement and to monitor treatment response to systemic therapies like tyrosine kinase inhibitors in case of deep or desmoid fibromatoses wh...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Srinivas Ananth Kumar Harmandeep Singh Lileswar Kaman Ritambhra Nada Bhagwant Rai Mittal Source Type: research
Discordant Molecular Imaging Findings with 2-[ < sup > 18 < /sup > F]FDG and [ < sup > 68 < /sup > Ga]Ga-PSMA PET/CT in a Patient with Both Bladder and Prostate Cancer
We present a case of double primary cancer involving the bladder and prostate, where the prostatic primary showed intense [68Ga]Ga-PSMA uptake with non-avid skeletal and pulmonary metastases, which showed intense 2-[18F]FDG uptake, thus showing discordance due to different clonal origins.PMID:38633286 | PMC:PMC11018560 | DOI:10.1007/s13139-024-00839-4 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Aparna Mahalik Jasim Jaleel Sambit Sagar Dikhra Khan Shobhana Raju Rakesh Kumar Source Type: research
First Local Experience of Intra-Cavitary Yttrium-90 Citrate Colloid Irradiation via Ommaya Reservoir for Refractory Cystic Craniopharyngioma: a Case Report
Nucl Med Mol Imaging. 2024 May;58(3):129-139. doi: 10.1007/s13139-024-00838-5. Epub 2024 Jan 16.ABSTRACTCraniopharyngioma is uncommon benign intracranial tumour that can be cured by surgical resection followed by conventional radiotherapy. However, its anatomical localisation makes the treatment hazardous or impossible. This case report aims to discuss the first local experience of using beta-emitting Yttrium-90 radioisotope in treating a patient with refractory cystic craniopharyngioma. A 43-year-old male who has underlying refractory cystic craniopharyngioma complicated with visual impairment and panhypopituitarism was r...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Nadiah Abd Razak Pung Choon Ping Kamalia Kamarulzaman Siti Zarina Amir Hassan Source Type: research
Incidentally Detected Gallbladder Carcinoma: Can F-18 FDG PET/CT Aid in Staging and Prognostication?
CONCLUSION: FDG-PET/CT detects residual and metastatic disease in patients with IGBC, enabling the institution of appropriate management and acting as a tool for prognostication of survival.PMID:38633288 | PMC:PMC11018561 | DOI:10.1007/s13139-024-00841-w (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Venkata Subramanian Krishnaraju Rajender Kumar Bhagwant Rai Mittal Harjeet Singh Piyush Aggarwal Harmandeep Singh Thakur Deen Yadav Ritambhra Nada Vikas Gupta Rajesh Gupta Source Type: research
Hepatic Superscan in Medullary Thyroid Carcinoma: A Rare Presentation in [ < sup > 18 < /sup > F]FDG PET/CT
Nucl Med Mol Imaging. 2024 May;58(3):147-149. doi: 10.1007/s13139-023-00836-z. Epub 2024 Jan 18.NO ABSTRACTPMID:38633289 | PMC:PMC11018564 | DOI:10.1007/s13139-023-00836-z (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Ahmed Saad Abdlkadir Dhuha Al-Adhami Baraa Alsyouf Raghad Alhouwari Ula Al-Rasheed Omar Jaber Issa Mohamad Akram Al-Ibraheem Source Type: research
Uncertainty Analysis of Time-Integrated Activity Coefficient in Single-Time-Point Dosimetry Using Bayesian Fitting Method
CONCLUSION: We introduce the BF method to calculate the SD of individual TIACs in STP dosimetry. The presented method might be used as an alternative method for uncertainty analysis in STP dosimetry.SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13139-024-00851-8.PMID:38633290 | PMC:PMC11018592 | DOI:10.1007/s13139-024-00851-8 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Achmad Faturrahman Jundi M Dlorifun Naqiyyun Bisma Barron Patrianesha Intan A S Mu'minah Ade Riana Deni Hardiansyah Source Type: research
Recent Updates on Applications of Artificial Intelligence for Nuclear Medicine Professionals: Prostate Cancer and PET/CT
Nucl Med Mol Imaging. 2024 May;58(3):97-100. doi: 10.1007/s13139-024-00856-3. Epub 2024 Feb 24.NO ABSTRACTPMID:38633291 | PMC:PMC11018562 | DOI:10.1007/s13139-024-00856-3 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Ki-Seong Park Source Type: research
A robust computational quest: Discovering potential hits to improve the treatment of pyrazinamide-resistant Mycobacterium tuberculosis
This study utilizes a novel integration of computational techniques, including multiscale biomolecular and molecular dynamics simulations, physicochemical and medicinal chemistry predictions, quantum computations and virtual screening from the ZINC and Chembridge databases, to elucidate the resistance mechanism and identify lead compounds that have the potential to improve treatment outcomes for PZA-resistant MTB, namely ZINC15913786, ZINC20735155, Chem10269711, Chem10279789 and Chem10295790. These computational methods offer a cost-effective, rapid alternative to traditional drug trials by bypassing the need for organic s...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Muhammad Shahab Gabriel Christian de Farias Morais Shopnil Akash Umberto Laino Fulco Jonas Ivan Nobre Oliveira Guojun Zheng Shahina Akter Source Type: research
Malformations of cortical development: Fetal imaging and genetics
CONCLUSION: The results suggest that genetic testing, especially WES, should be performed for fetal MCD, in order to evaluate the outcomes and prognosis, and predict the risk of recurrence in future pregnancies.PMID:38634212 | DOI:10.1002/mgg3.2440 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Lin-Lin Wang Ping-Shan Pan Hui Ma Chun He Zai-Long Qin Wei He Jing Huang Shu-Yin Tan Da-Hua Meng Hong-Wei Wei Ai-Hua Yin Source Type: research
Association of a genetic variant in angiopoietin-like 3 with serum HDL-C and risk of cardiovascular disease: A study of the MASHAD cohort over 6  years
CONCLUSION: We have found that a rs10789117 C>A in ANGPTL3 gene polymorphism was associated with incident CVD events, and this may be of value as a risk stratification biomarker in CVD in the Iranian population.PMID:38634215 | DOI:10.1002/mgg3.2418 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Malihe Aghasizadeh Asieh Ahmadi Hoseini Reza Sahebi Tooba Kazemi Parisa Asadiyan-Sohan Habibollah Esmaily Sara Samadi Amir Avan Gordon A Ferns Saeede Khosravi Hamideh Ghazizadeh Ebrahim Miri-Moghaddam Majid Ghayour-Mobarhan Source Type: research
Impacts of pro-inflammatory cytokines variant on cardiometabolic profile and premature coronary artery disease: A systematic review and meta-analysis
J Cell Mol Med. 2024 Apr;28(8):e18311. doi: 10.1111/jcmm.18311.ABSTRACTInterleukin-6 (IL-6), a pivotal pro-inflammatory cytokine, is closely linked to vascular wall thickening and atherosclerotic lesion. Since serum IL-6 levels are largely determined by the genetic variant in IL-6, this study was conducted to investigate whether the IL-6 variant impacts cardiometabolic profile and the risk of premature coronary artery disease (PCAD). PubMed, Cochrane Library, Central, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and ClinicalTrials.gov were searched from May 13, 2022 to June 28, 2023. In total, 40 stud...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Yang Liu Yuan Chen Yi Lin Baozhu Wei Zhi Luo Source Type: research
Are asymptomatic carriers of OTC deficiency always asymptomatic? A multicentric retrospective study of risk using the UCDC longitudinal study database
CONCLUSIONS: Analysis of Asx and Asx/Sym females with OTCD in this study suggests that future evidence-based management guidelines and/or a clinical risk score calculator for this cohort could be useful management tools to reduce morbidity and improve long-term quality of life.PMID:38634223 | DOI:10.1002/mgg3.2443 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Kuntal Sen Rima Izem Yuelin Long Jiji Jiang Laura L Konczal Robert J McCarter Members of the Urea Cycle Disorders Consortium (UCDC) Andrea L Gropman Jirair K Bedoyan Source Type: research
Same-day post-therapy imaging with a new generation whole-body digital SPECT/CT in assessing treatment response to [ < sup > 177 < /sup > Lu]Lu-PSMA-617 in metastatic castration-resistant prostate cancer
CONCLUSION: We successfully implemented same-day post-therapy SPECT/CT after [177Lu]Lu-PSMA-617 infusions. Quantitation of 1-2 h post-therapy SPECT/CT images is a promising method for assessing treatment response. However, the approach is currently limited by its suboptimal detection of small tumor lesions and the necessity of incorporating a third-cycle SPECT/CT to mitigate the effects of any potential treatment-related flare-up. Further investigation in a larger patient cohort and prospective validation is essential to confirm these findings and to explore the role of SPECT/CT as a potential adjunct to PSMA PET/CT in man...
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Hong Song Maria Isabel Leonio Valentina Ferri Heying Duan Carina Mari Aparici Guido Davidzon Benjamin L Franc Farshad Moradi Jagruti Shah Colin P Bergstrom Alice C Fan Sumit Shah Ali Raza Khaki Sandy Srinivas Andrei Iagaru Source Type: research
