A Case of Incidentally Discovered Congenital Complete Pericardial Defect during Lobectomy for Lung Cancer: A Case Report and Literature Review
Ann Thorac Cardiovasc Surg. 2024;30(1). doi: 10.5761/atcs.cr.24-00041.ABSTRACTAn 82-year-old male patient underwent a left upper lobectomy with anterolateral thoracotomy for lung cancer. Although a complete left-pericardial defect was observed during surgery, the pericardial repair was not performed because the left lower lobe remained and the heart was considered stable. Postoperative pathological examination revealed primary synchronous double-lung squamous-cell carcinoma (pathological stage pT2a(2)N0M0 stage IB). He was discharged without complications on postoperative day 8. Leftward displacement of the heart and left ...
Source: Annals of Thoracic and Cardiovascular Surgery - May 15, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Tomohiro Setogawa Taketo Kato Hiroki Watanabe Shota Nakamura Tetsuya Mizuno Toyofumi Fengshi Chen-Yoshikawa Source Type: research
Predictive Performance of Radiomic Features Extracted from Breast MR Imaging in Postoperative Upgrading of Ductal Carcinoma in Situ to Invasive Carcinoma
CONCLUSION: A radiomics approach using breast MRI may be a promising method for predicting the postoperative upgrade of DCIS. The present study showed that the radiomic features extracted from pre-contrast T1WI and post-contrast subtraction images in the very early phase of DCE-MRI were more predictable.PMID:38749758 | DOI:10.2463/mrms.mp.2023-0168 (Source: Magnetic Resonance in Medical Sciences)
Source: Magnetic Resonance in Medical Sciences - May 15, 2024 Category: Radiology Authors: Hiroko Satake Fumie Kinoshita Satoko Ishigaki Keita Kato Yusuke Jo Satoko Shimada Norikazu Masuda Shinji Naganawa Source Type: research
The truncated AXIN1 isoform promotes hepatocellular carcinoma metastasis through SRSF9-mediated exon 9 skipping
In this study, we explored the potential molecular mechanisms that connect alternative splicing of AXIN1 to the metastasis of hepatocellular carcinoma (HCC). Transcriptome sequencing, RT‒PCR, qPCR and Western blotting were utilized to determine the expression levels of AXIN1 in human HCC tissues and HCC cells. The effects of the AXIN1 exon 9 alternative splice isoform and SRSF9 on the migration and invasion of HCC cells were assessed through wound healing and Transwell assays, respectively. The interaction between SRSF9 and AXIN1 was investigated using UV crosslink RNA immunoprecipitation, RNA pulldown, and RNA immunopre...
Source: Molecular and Cellular Biochemistry - May 15, 2024 Category: Biochemistry Authors: Qian-Qian Zhang Ying-Shuang Miao Jun-Yi Hu Rui-Xuan Liu Yue-Xiao Hu Feng Wang Source Type: research
New Carbothioamide and Carboxamide Derivatives of 3-Phenoxybenzoic Acid as Potent VEGFR-2 Inhibitors: Synthesis, Molecular Docking, and Cytotoxicity Assessment
CONCLUSION: Overall, the findings suggest that compound 4b has a promising future as a starting point for the development of new anticancer drugs.PMID:38747227 | DOI:10.2174/0115680096307334240429050730 (Source: Current Cancer Drug Targets)
Source: Current Cancer Drug Targets - May 15, 2024 Category: Cancer & Oncology Authors: Mohammad Hamza Heriz Ammar A Razzak Mahmood Lubna H Tahtamouni Mai F AlSakhen Sana I Kanaan Khaled M Saleh Salem R Yasin Source Type: research
Breaking the Mucin Barrier: A New Affinity Chromatography-Mass Spectrometry Approach to Unveil Potential Cell Markers and Pathways Altered in Pseudomyxoma Peritonei
CONCLUSIONS: In sum, our results demonstrate that this protein isolation protocol from mucin will have a high impact, allowing the oncology research community to more rapidly advance in the knowledge of PMP and other mucinous neoplasms, as well as develop new and effective therapeutic strategies.PMID:38750435 | PMC:PMC11094946 | DOI:10.1186/s12575-024-00239-0 (Source: Biological Procedures Online)
Source: Biological Procedures Online - May 15, 2024 Category: Molecular Biology Authors: Antonio Romero-Ruiz Melissa Granados-Rodr íguez Florina I Bura Francisca Valenzuela-Molina Blanca Rufi án-Andújar Ana Mart ínez-López Lidia Rodr íguez-Ortiz Rosa Ortega-Salas Mar ía Torres-Martínez Ana Moreno-Serrano Justo Casta ño Carmen Mich á Source Type: research
Minimally-invasive conservative techniques in management of thyroid carcinoma: a narrative review
Acta Otorhinolaryngol Ital. 2024 May;44(Suppl. 1):S82-S85. doi: 10.14639/0392-100X-suppl.1-44-2024-N2843.NO ABSTRACTPMID:38745519 | PMC:PMC11098533 | DOI:10.14639/0392-100X-suppl.1-44-2024-N2843 (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - May 15, 2024 Category: ENT & OMF Authors: Valentina de Robertis Gaetano Achille Francesco Barbara Francesco Caivano Roberta Anzivino Pierre Guarino Michele Barbara Source Type: research
Transoral robotic surgery for supraglottic cancer. A review of oncological and functional outcomes compared to open surgery
CONCLUSIONS: Although recently introduced in the treatment of laryngeal pathology, TORS has been shown to be a reliable technique not only for functional but also for oncological outcomes, ensuring good overall survival, disease-free survival, and disease control rates comparable to OPHL I.PMID:38745513 | PMC:PMC11098539 | DOI:10.14639/0392-100X-suppl.1-44-2024-N2919 (Source: Acta Otorhinolaryngologica Italica)
Source: Acta Otorhinolaryngologica Italica - May 15, 2024 Category: ENT & OMF Authors: Claudio Donadio Caporale Francesco Chiari Pasquale D'Alessio Francesco Barbara Pierre Guarino Source Type: research
Predictive Performance of Radiomic Features Extracted from Breast MR Imaging in Postoperative Upgrading of Ductal Carcinoma in Situ to Invasive Carcinoma
CONCLUSION: A radiomics approach using breast MRI may be a promising method for predicting the postoperative upgrade of DCIS. The present study showed that the radiomic features extracted from pre-contrast T1WI and post-contrast subtraction images in the very early phase of DCE-MRI were more predictable.PMID:38749758 | DOI:10.2463/mrms.mp.2023-0168 (Source: Magnetic Resonance in Medical Sciences : MRMS)
Source: Magnetic Resonance in Medical Sciences : MRMS - May 15, 2024 Category: Radiology Authors: Hiroko Satake Fumie Kinoshita Satoko Ishigaki Keita Kato Yusuke Jo Satoko Shimada Norikazu Masuda Shinji Naganawa Source Type: research
Evaluation of long-term outcome following therapeutic mammaplasty: the effect of wound complication on initiation of adjuvant therapy and subsequent oncological outcome
CONCLUSION: Our study finding demonstrates that although wound complications after TM leads to a modest delay to adjuvant therapy, the long-term oncological outcomes were comparable with those in patients without wound complications.PMID:38746984 | DOI:10.1308/rcsann.2023.0095 (Source: Annals of the Royal College of Surgeons of England)
Source: Annals of the Royal College of Surgeons of England - May 15, 2024 Category: Surgery Authors: R Rampal S Jones W Hogg B Rengabashyam B Hogan R Achuthan B Kim Source Type: research
Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc
This study aimed to investigate the effects of ZNF471 N-glycosylation on the proliferation, invasion, and docetaxel sensitivity of tongue squamous cell carcinoma (TSCC). It analyzed the expression, function, and prognostic significance of ZNF471 in TSCC using bioinformatics techniques such as gene differential expression analysis, univariate Cox regression analysis, functional enrichment analysis, and gene set enrichment analysis. Using site-specific mutagenesis, this study generated three mutant sites for ZNF471 N-glycosylation to determine the effect of N-glycosylation on ZNF471 protein levels and function. Quantitative ...
Source: Am J Pathol - May 15, 2024 Category: Pathology Authors: Yan Liu Xu Cai Shousen Hu Zhen Wang Hao Tian Honghan Wang Source Type: research
Suppression of N-Glycosylation of Zinc Finger Protein 471 Affects Proliferation, Invasion, and Docetaxel Sensitivity of Tongue Squamous Cell Carcinoma via Regulation of c-Myc
This study aimed to investigate the effects of ZNF471 N-glycosylation on the proliferation, invasion, and docetaxel sensitivity of tongue squamous cell carcinoma (TSCC). It analyzed the expression, function, and prognostic significance of ZNF471 in TSCC using bioinformatics techniques such as gene differential expression analysis, univariate Cox regression analysis, functional enrichment analysis, and gene set enrichment analysis. Using site-specific mutagenesis, this study generated three mutant sites for ZNF471 N-glycosylation to determine the effect of N-glycosylation on ZNF471 protein levels and function. Quantitative ...
Source: The American Journal of Pathology - May 15, 2024 Category: Pathology Authors: Yan Liu Xu Cai Shousen Hu Zhen Wang Hao Tian Honghan Wang Source Type: research
Evaluation of BH3 mimetics as a combination therapy with irradiation in head and neck squamous cell carcinoma
CONCLUSIONS: Our findings encourage the further preclinical investigation of BH3 mimetics, particularly A-1331852, as a single agent or combined with irradiation as a treatment for HNSCC.PMID:38749173 | DOI:10.1016/j.biopha.2024.116719 (Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie)
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - May 15, 2024 Category: Drugs & Pharmacology Authors: Katja Korelin Mayke Oostveen Wafa Wahbi Filipp Ianevski Bruno Cavalcante Laura Turunen Ilya Belevich Ahmed Al-Samadi Tuula Salo Source Type: research
GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma
In this study, we generated GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK for the treatment of HCC. GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK specifically and effectively lysed GPC3-positive tumor cells in vitro in an antigen-dependent manner. Furthermore, GLUT1 or AGK overexpression protected CAR-T cells from apoptosis during repeated exposures to tumor cells. Compared with second-generation CAR-T cells, GPC3-targeted CAR-T cells overexpressing GLUT1 or AGK exhibited greater CD8+ T-cell persistence in vivo and better antitumor effects in HCC allograft mouse models. Finally, we revealed that GLUT1 or AG...
Source: Acta Pharmacologica Sinica - May 15, 2024 Category: Drugs & Pharmacology Authors: Rui-Xin Sun Yi-Fan Liu Yan-Sha Sun Min Zhou Yi Wang Bi-Zhi Shi Hua Jiang Zong-Hai Li Source Type: research
Exploring the Molecular Mechanisms of Huaier on Modulating Metabolic Reprogramming of Hepatocellular Carcinoma: A Study based on Network Pharmacology, Molecular Docking and Bioinformatics
CONCLUSION: This study provided a workflow for understanding the mechanism of Huaier in regulating the metabolic reprogramming of HCC.PMID:38747231 | DOI:10.2174/0113816128287535240429043610 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 15, 2024 Category: Drugs & Pharmacology Authors: Yuxiang Wan Honglin Jiang Zeyu Liu Chen Bai Yanyan Lian Chunguang Zhang Qiaoli Zhang Jinchang Huang Source Type: research
Exploring the impact of insufficient thermal ablation on hepatocellular carcinoma: NDST2 overexpression mechanism and its role in facilitating growth and invasion of residual cancer cells
CONCLUSION: The upregulation of NDST2 can accelerate the progression of residual HCC after ITA, suggesting a potential role for NDST2 in the therapeutic efficacy and prognosis of residual HCC.PMID:38749506 | DOI:10.1080/02656736.2024.2353309 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 15, 2024 Category: Internal Medicine Authors: Weijun Wan Danxia Guo Tong Kang Jinshu Pang Yunjing Pan Jiamin Chen Wei Liao Yuji Chen Peng Lin Lipeng Li Hong Yang Yun He Source Type: research
