Advances in Forensic Toxicology.
e; FP PMID: 32942971 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 21, 2020 Category: Drugs & Pharmacology Authors: Malaca S, Carlier J, Busardò FP Tags: Curr Pharm Des Source Type: research

Targeted Drug Delivery and Theragnostics.
PMID: 32942972 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 21, 2020 Category: Drugs & Pharmacology Authors: Kairemo K Tags: Curr Pharm Des Source Type: research

Beneficiary and Adverse Effects of Phytoestrogens: A Potential Constituent of Plant Based Diet.
CONCLUSION: The present review emphasizes the pros and cons of phytoestrogens on human health, which may help to direct the pharmaceutical industry to produce various phytoestrongen based drugs against various metabolic disorders. PMID: 32942973 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 17, 2020 Category: Drugs & Pharmacology Authors: Vaadala S, Ponneri N, Karnam VS, Pamuru RR, Arifullah M Tags: Curr Pharm Des Source Type: research

Mucoadhesive Formulation Designs for Oral Controlled Drug Release at the Colon.
Abstract Mucoadhesive formulations have been demonstrated to result in efficient drug delivery systems with advantages over existing systems such as increased local retention and sustained drug release via adhesiveness to mucosal tissues. The controlled release of colon-targeted, orally administered drugs has recently attracted a number of studies investigating mucoadhesive systems. Consequently, substantial designs, from mucoadhesive cores to shells of particles, have been studied with promising applications. This review will provide an overview of and discuss specific strategies for developing mucoadhesive syste...
Source: Current Pharmaceutical Design - September 17, 2020 Category: Drugs & Pharmacology Authors: Tran PHL, Tran TTD Tags: Curr Pharm Des Source Type: research

Expression of Rab3b in Human Glioma: Influence on Cell Proliferation and Apoptosis.
CONCLUSION: Rab3b expression levels are significantly related to the progression of gliomas. Moreover, Rab3b silencing not only significantly inhibits cell proliferation in gliomas via cell cycle arrest but also promotes cell apoptosis by upregulating the expression levels of apoptosis-related proteins, however these preliminary in vitro results warrant validation on in vivo studies. PMID: 32940170 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 17, 2020 Category: Drugs & Pharmacology Authors: Luo Q, Liu Y, Yuan Z, Huang L, Diao B Tags: Curr Pharm Des Source Type: research

Comparison of efficacy and peripheral neuropathy of solvent-based paclitaxel with paclitaxel poliglumex and NK105: A systematic review and meta-analysis.
Abstract Peripheral neuropathy is one of the most common dose-limiting side effects of solvent-based paclitaxel. Paclitaxel poliglumex (PPX) and NK105 were developed to overcome the paclitaxel induced peripheral neuropathy. However, the incidence of peripheral neuropathy induced by PPX and NK105 was reported higher than solvent-based paclitaxel, but evidence remains inconsistent. Therefore, we conducted a meta-analysis to compare the incidence and severity of peripheral neuropathy between solvent-based paclitaxel, PPX and NK105 mono-chemotherapy. Results revealed that no significant difference exists between the i...
Source: Current Pharmaceutical Design - September 17, 2020 Category: Drugs & Pharmacology Authors: Taheri A, Rad A, Sadeghi E, Varshosaz J Tags: Curr Pharm Des Source Type: research

Molecular hydrogen application in stroke: bench to bedside.
Abstract Stroke is a major cause of mortality and morbidity worldwide. Effective treatments are limited. Molecular hydrogen is emerging as a novel medical gas with therapeutic potential for various neurological diseases, including stroke. We reviewed the experimental and clinical findings of the effects of molecular hydrogen therapy in stroke patients and models. The underlying neuroprotective mechanisms aganist stroke pathology were also discussed. PMID: 32940172 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 17, 2020 Category: Drugs & Pharmacology Authors: Huang L, Lenahan C, Boling W, Tang J, Zhang JH Tags: Curr Pharm Des Source Type: research

Regulation of Electrolyte Permeability by Herbal Monomers in Edematous Disorders.
In conclusion, the natural herbal monomers regulate electrolyte permeability in many edematous disorders, and further basic and clinical studies are needed. PMID: 32940173 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 17, 2020 Category: Drugs & Pharmacology Authors: Cui Y, Hou Y, Zhang H, Liu Y, Mao K, Nie H, Ding Y Tags: Curr Pharm Des Source Type: research

Oncogenic LncRNA CASC9 in Cancer Progression.
CONCLUSION: Long non-coding RNACASC9 likely served as useful disease biomarkers or therapy targets that could effectively apply in treatment of different kinds of cancers. PMID: 32940174 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 17, 2020 Category: Drugs & Pharmacology Authors: Qi Y, Song C, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

Toxicological Aspects of Carbon Nanotubes, Fullerenes and Graphenes.
Abstract Nanomedicines exhibit unbelievable capability in overcoming the hurdles faced in biological applications. Carbon nanotubes (CNTs), graphene-family nanomaterials and fullerenes are a class of engineered nanoparticles that have emerged as a new option for possible use in drug/gene delivery for life-threatening diseases. Their adaptability to pharmaceutical applications have opened new vistas for biomedical applications. Successful applications of this family of engineered nanoparticles in various fields may not support its use in medicine due to inconsistent data on toxicity as well as the lack of a central...
Source: Current Pharmaceutical Design - September 16, 2020 Category: Drugs & Pharmacology Authors: Shah P, Lalan M, Jani D Tags: Curr Pharm Des Source Type: research

Association between Thiopurines Use and Pregnancy Outcomes in Female Patients with Inflammatory Bowel Disease: A Meta-analysis.
CONCLUSION: Thiopurines' use in women with IBD during pregnancy is not associated with congenital malformations, LBW, SGA, or spontaneous abortion, but appears to have an association with an increased risk of preterm birth. PMID: 32938343 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2020 Category: Drugs & Pharmacology Authors: Zhang Y, Li D, Guo H, Wang W, Li X, Shen S Tags: Curr Pharm Des Source Type: research

The Effects of P75NTR on Learning Memory Mediated by Hippocampal Apoptosis and Synaptic Plasticity.
This article mainly discusses the relationship between p75NTR and learning memory and associated mechanisms, which may provide some new ideas for the treatment of neurological diseases. PMID: 32938344 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2020 Category: Drugs & Pharmacology Authors: Tang JJ, Feng S, Chen XD, Huang H, Mao M, Wang HY, Li S, Lu XM, Wang YT Tags: Curr Pharm Des Source Type: research

Topical Ocular Delivery of Nanocarriers: A Feasible Choice for Glaucoma Management.
Abstract Topical ocular delivery is an acceptable and familiar approach for the treatment of common ocular diseases. Novel strategies for the treatment of inherited eye diseases include new pharmacologic agents, gene therapy and genome editing, which lead to expansion of new management options for eye disorders. Topical ocular delivery of nanocarriers is a technique, which has the potential to facilitate novel treatments. Nanocarrier-based strategies have proven effective for site-targeted delivery. This review summarizes recent development in the area of topical delivery of different nanocarriers (Polymer, Vesicu...
Source: Current Pharmaceutical Design - September 16, 2020 Category: Drugs & Pharmacology Authors: Kesavan K, Mohan P, Gautam N, Sheffield VC Tags: Curr Pharm Des Source Type: research

New Therapies for Endothelial Dysfunction: From Basic to Applied Research.
PMID: 32893756 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 9, 2020 Category: Drugs & Pharmacology Authors: Dos Santos L Tags: Curr Pharm Des Source Type: research

Chitin Biology and Beyond: Chemical Biology Aiming to Enhanced Chitin Utilization and Insect Pest Control.
PMID: 32893757 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 9, 2020 Category: Drugs & Pharmacology Authors: Fukamizo T, Yang Q Tags: Curr Pharm Des Source Type: research

Immunosupression in Solid Organ Transplantation: Standard of Care and Future Directions.
PMID: 32883196 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 5, 2020 Category: Drugs & Pharmacology Authors: Chedid MF Tags: Curr Pharm Des Source Type: research

Edible mushrooms: Novel medicinal agents to combat metabolic syndrome and associated diseases.
Abstract Metabolic syndrome is an aggregation of conditions and associated with an increased risk of developing diabetes, obesity and cardiovascular diseases (CVD). Edible mushrooms are widely consumed in many countries and are valuable components of the diet because of their attractive taste, aroma, and nutritional value. Medicinal mushrooms are higher fungi with additional nutraceutical attributes having low fat content and a trans-isomer of unsaturated fatty acids along with high fiber content, biologically active compounds such as polysaccharides or polysaccharide β-glucans, alkaloids, steroids, polypheno...
Source: Current Pharmaceutical Design - August 31, 2020 Category: Drugs & Pharmacology Authors: Tung YT, Pan CH, Chien YW, Huang HY Tags: Curr Pharm Des Source Type: research

Therapeutic Advancements in Management of Diabetes Mellitus with Special Reference to Nanotechnology.
Abstract For improvisation of diabetic's quality of life, nanotechnology is facilitating the development of advanced glucose sensors as well as efficient insulin delivery systems. Our prime focus of the review is to highlight the advancement in diabetic research with special reference to nanotechnology at its interface. Recent studies are more focused on enhancing sensitivity, accuracy, and response by employing metal as well as nanoparticles based glucose sensors. Moreover, the review focuses on nanoscale based approaches i.e. closed-loop insulin delivery systems which detects any fluctuation in blood glucose lev...
Source: Current Pharmaceutical Design - August 26, 2020 Category: Drugs & Pharmacology Authors: Chauhan PS, Yadav D, Tayal S, Jin JO Tags: Curr Pharm Des Source Type: research

Elevated Urinary and Blood Vascular Cell Adhesion Molecule-1 as Potential Biomarkers for Active Systemic Lupus Erythematosus: a Meta- analysis.
CONCLUSION: Compared with inactive SLE patients, patients with active SLE have higher levels of VCAM-1 in both urine and blood. VCAM-1 may be a potential indicator of SLE disease activity. PMID: 32851953 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 26, 2020 Category: Drugs & Pharmacology Authors: Xia YR, Mao YM, Wang JP, Li QR, Fan YG, Pan HF, Ye DQ Tags: Curr Pharm Des Source Type: research

Nanocarrier based Topical Drug Delivery- A Promising Strategy for Treatment of Skin Cancer.
Abstract Skin cancers are one of the most widespread and complex forms of the disease, resulting in very high mortality rates across the world. The current treatments available for skin cancer include chemotherapy, surgery, radiotherapy, etc. The selected treatment options for skin cancer are usually decided based on the condition of a patient and the type of skin cancer. The effectiveness of skin cancer therapy is still limited because of poor penetrability of the drug into stratum corneum or lesions, low efficacy, required higher concentration of the active pharmaceutical ingredients to reach a therapeutic effec...
Source: Current Pharmaceutical Design - August 26, 2020 Category: Drugs & Pharmacology Authors: Jain R, Sarode I, Singhvi G, Dubey SK Tags: Curr Pharm Des Source Type: research

Flavonoids as potential therapeutic agents for the management of diabetic neuropathy.
Abstract Flavonoids are secondary metabolites that are widely distributed in plants. These phenolic compounds are classified into various subgroups based on their structures: flavones, flavonols, isoflavones, flavanones and anthocyanins. They are known to perform various pharmacological actions like antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic and antiallergic, etc. Diabetes is a chronic progressive metabolic disorder that affects several biochemical pathway and leads to secondary complications such as neuropathy, retinopathy, nephropathy and cardiomyopathy. Among them, management of dia...
Source: Current Pharmaceutical Design - August 26, 2020 Category: Drugs & Pharmacology Authors: Sood A, Kumar B, Singh SK, Prashar P, Gautam A, Gulati M, Pandey NK, Melkani I, Awasthi A, Saraf SA, Vidari G, Ozdemir M, Hussain FHS, Anwar ET, Ameen MSM, Gupta S, Porwal O Tags: Curr Pharm Des Source Type: research

Mitochondrial-induced epigenetic modifications: from biology to clinical translation.
Abstract Mitochondria are maternally inherited semi-autonomous organelles that play a central role in redox balance, energy metabolism, control of integrated stress responses, and cellular homeostasis. The molecular communication between mitochondria and the nucleus is intricate and bidirectional in nature. Though mitochondrial genome encodes for a number of key proteins involved in oxidative phosphorylation, several regulatory factors encoded by nuclear DNA are prominent contributors to mitochondrial biogenesis and function. The loss of synergy between this reciprocal control of anterograde (nuclear to mitochondr...
Source: Current Pharmaceutical Design - August 26, 2020 Category: Drugs & Pharmacology Authors: Sharma J, Kumari R, Bhargava A, Tiwari R, Mishra PK Tags: Curr Pharm Des Source Type: research

Epithelial Barrier Dysfunction Induced by Hypoxia in Respiratory System.
Abstract Steady and continuous supply of oxygen is important for humans, since an excess or deficiency in oxygen levels may result in the death of cells, tissue, or the organism. As a mechanical barrier against pathogens, the respiratory epithelium is always exposed to hypoxia in some detrimental external environment and/or pathologic state. The barrier function is accordingly impaired as a result of disrupted cell composition ratio, ion transport, and tight junctions in a hypoxia-inducible factor dependent or independent way. Hypoxia has been identified as an element of the primary or secondary pathogenic factors...
Source: Current Pharmaceutical Design - August 25, 2020 Category: Drugs & Pharmacology Authors: Hou Y, Ding Y, Liu Y, Xie X, Cui Y, Nie H Tags: Curr Pharm Des Source Type: research

Effect of Capsinoids Supplementation on Fat Oxidation and Muscle Glycogen Restoration During Post-exercise Recovery in Humans.
Conclusion: Our findings conclude that acute CSN intake could change energy reliance on fat oxidation, but unable to enhance muscle glycogen resynthesis during post-exercise recovery. Thus, ergogenic properties of CSN in relevance to muscle glycogen restoration following exercise needs to be further investigated in young adults. PMID: 32838710 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 23, 2020 Category: Drugs & Pharmacology Authors: Liao SF, Korivi M, Taso JP, Huang CC, Chang CC, Cheng IS Tags: Curr Pharm Des Source Type: research

Melatonin Protects HT22 Hippocampal Cells from H2O2-induced Injury by Increasing Beclin1 and Atg Protein Levels to Activate Autophagy.
Conclusion: In conclusion, these results demonstrate that melatonin protects HT22 hippocampal neurons from H2O2- induced injury by increasing the levels of the Beclin1 and Atg proteins to activate autophagy. PMID: 32838711 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 23, 2020 Category: Drugs & Pharmacology Authors: Gao Q, Guo X, Cao Y, Jia X, Xu S, Lu C, Zhu H Tags: Curr Pharm Des Source Type: research

A Comprehensive Review on Nanotechnology-Based Innovations in Topical Drug Delivery for Treatment of Skin Cancer.
CONCLUSION: In the present review, we have discussed various novel carrier systems being investigated for the topical application of chemotherapeutic agents for efficient skin targeting and better dermatological as well as therapeutic benefits with minimal systemic exposure and toxicity. PMID: 32814523 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 19, 2020 Category: Drugs & Pharmacology Authors: Lalotra AS, Singh V, Khurana B, Agrawal S, Shrestha S, Arora D Tags: Curr Pharm Des Source Type: research

Theoretical and Spectroscopic Characterization of API-Related Azoles in Solution and in Solid State.
rta I Abstract Azoles are a family of five-membered azacyclic compounds with relevant biological and pharmacological activity. Different subclasses of azoles are defined depending on the atomic arrangement and the number of nitrogen atoms present in the ring: pyrazoles, indazoles, imidazoles, benzimidazoles, triazoles, benzotriazoles, tetrazoles and pentazoles. The complete characterization of their structure and the knowledge about their crystal packing and physical and chemical properties are of vital importance to advance in the design of new azole-containing drugs. In this review, we report the latest recent c...
Source: Current Pharmaceutical Design - August 18, 2020 Category: Drugs & Pharmacology Authors: Marín-Luna M, Claramunt RM, Elguero J, Alkorta I Tags: Curr Pharm Des Source Type: research

Prevention Knowledge and Its Practice Towards COVID-19 Among General Population of Saudi Arabia: A Gender-based Perspective.
CONCLUSION: This study shows that women were more compliant to the WHO public health covid-19 prevention advice than men which can decrease the chances of covid-19 infection. PMID: 32811408 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 18, 2020 Category: Drugs & Pharmacology Authors: Alshammary F, Siddiqui AA, Amin J, Ilyas M, Rathore HA, Hassan I, Alam MK, Kamal MA Tags: Curr Pharm Des Source Type: research

System Biology Methods and Tools for Pharmaceutical Design.
PMID: 32787750 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 15, 2020 Category: Drugs & Pharmacology Authors: Cheng L Tags: Curr Pharm Des Source Type: research

Engineered Site Specific Vesicular Systems for Colonic Delivery: Trends and Implications.
Abstract Steering drug loaded, site-specific, coated lipid vesicles to the target receptor sites has the potential of plummeting adverse effects and improving the pharmacological response in diverse pathologies of large bowel, especially colon. Colonic delivery via oral route has its own challenges, often governed by several glitches such as drug degradation or absorption in the upper GIT, instability of proteins/peptides due to high molecular weight and peptidase activity in the stomach. Consequently, colon specific coated liposomal systems (CSLS) offer a potential alternate for not only site specificity, but pro...
Source: Current Pharmaceutical Design - August 13, 2020 Category: Drugs & Pharmacology Authors: Goel H, Razdan K, Singla R, Talegaokar S, Khurana RK, Tiwary AK, Sinha VR, Singh KK Tags: Curr Pharm Des Source Type: research

Role of histamine as a peripheral sympathetic neuromediator and its interrelation with substance P.
Abstract With this article we wanted to carry out an educational review about of the fundamental aspects related to the proposal of the existence of a peripheral sympathetic reflex regulated by Histamine, through its effect on presynaptic H3 type receptors, under the interaction of a sensory neurone that would be mediated by Substance P. In this respect, we consider it useful to highlight the role of Histamine, so we discuss some aspects about its history, metabolism, and function, as well as its interaction with H3 type receptors, considered as neuroreceptors, which define and typify it as a neuromediator at both...
Source: Current Pharmaceutical Design - August 13, 2020 Category: Drugs & Pharmacology Authors: Atencio ASM, de Manzo FAP, Velasco M Tags: Curr Pharm Des Source Type: research

Imaging Techniques As An Aid In The Early Detection Of Cardiac Amyloidosis.
Abstract The idea that performing a proper succession of imaging tests and techniques allows an accurate and early diagnosis of cardiac amyloidosis, avoiding the need to perform myocardial biopsy, is becoming increasingly popular. Furthermore, being imaging techniques non-invasive, it is possible to perform the follow-up of the pathology through repeated image acquisitions. In the present review, the various innovative imaging methodologies are presented, and it is discussed how they have been applied for early diagnosis of cardiac amyloidosis (CA), also to distinguish the two most frequent subtypes in CA: immunog...
Source: Current Pharmaceutical Design - August 13, 2020 Category: Drugs & Pharmacology Authors: Santarelli MF, Scipioni M, Genovesi D, Giorgetti A, Marzullo P, Landini L Tags: Curr Pharm Des Source Type: research

Approach to the Patient with Subclinical Cushing's Syndrome.
Vujović S Abstract A growing number of patients with adrenal incidentalomas and subclinical Cushing's syndrome (SCS) led to a growing number of different guidelines, diagnostic and treatment recommendations. Excess cortisol secretion in patients with SCS is associated with a number of comorbidities, such as hypertension, dyslipidemia, type 2 diabetes mellitus and obesity, which in long-term increase mortality of these patients. Subtle cortisol secretion effects also bone health, quality of life and cause depression, but due to the unapparent clinical features, patients with SCS are often in risk between over and...
Source: Current Pharmaceutical Design - August 13, 2020 Category: Drugs & Pharmacology Authors: Ivović M, Marina LV, Šojat AS, Tančić-Gajić M, Arizanović Z, Kendereški A, Vujović S Tags: Curr Pharm Des Source Type: research

Pharmacokinetic Profile of Oxaliplatin-Loaded pH-Responsive Hydrogels in Rabbits.
CONCLUSION: HPLC-UV method was successfully optimized for OXP detection in oral solution and hydrogels administered to rabbits. A significant difference was found among various pharmacokinetic parameters by comparing the two groups including half-life (t1/2), tmax, Cmax, AUCtot MRT, Vz , and Lz . PMID: 32787758 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 13, 2020 Category: Drugs & Pharmacology Authors: Ullah K, Khan SA, Sohail M, Mannan A, Murtaza G Tags: Curr Pharm Des Source Type: research

Autophagic vacuole secretion triggered by chidamide participates in TRAIL apoptosis effect in breast cancer cells.
CONCLUSION: Our data are the first to demonstrate the synergistic effects of chidamide and TRAIL in BC cells, specifically, the pharmacological effects on cell death induction. These results lay a solid experimental and theoretical basis to solve the clinical resistance of chidamide. PMID: 32787747 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 11, 2020 Category: Drugs & Pharmacology Authors: Zhou W, Han H, Xu J, Sun T, Feng X Tags: Curr Pharm Des Source Type: research

Pentoxifylline and Oxypurinol: Potential Drugs to Prevent the "Cytokine Release (Storm) Syndrome" Caused by SARS-CoV-2?
CONCLUSION: Pentoxifylline and oxypurinol are licensed drugs used for diseases other than COVID-19 and, therefore, phase I clinical trials would not be necessary for administration to SARS-CoV2- infected people. It would be worth trying their potential effects against hyperinflammatory response to SARS-CoV2 infection. PMID: 32787748 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 11, 2020 Category: Drugs & Pharmacology Authors: López-Iranzo FJ, López-Rodas AM, Franco L, López-Rodas G Tags: Curr Pharm Des Source Type: research

Edible Nuts for Memory.
Abstract Nuts hold prime significance throughout the world as they offer multiple health benefits owing to their highly nutritious profile. A number of scientific studies have demonstrated their actions against inflammation, oxidative damage, the aging process, as well as dementia or memory loss. However, only walnuts, followed by almonds, hazelnuts and pistachios, have shown promising results in empirical studies for memory improvements. So, the current review focuses on presenting hypotheses regarding anti-dementia property of nine different nuts: almond, walnut, pistachio, Brazil nut, peanut, pecans, cashew, ha...
Source: Current Pharmaceutical Design - August 5, 2020 Category: Drugs & Pharmacology Authors: Arslan J, Gilani AU, Jamshed H, Khan SF, Kamal MA Tags: Curr Pharm Des Source Type: research

Larvicidal activity of essential oils against Aedes aegypti (Diptera: Culicidae).
FAB Abstract The Aedes aegypti is responsible for the transmission of arboviruses, which compromise public health. In the search for synthetic product alternatives, essential oils (OEs) have been highlighted by many researchers as natural insecticides. This systematic review (SR) was performed according to PRISMA guidelines (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and had as it's objective to evaluate studies addressing OEs with larvicidal properties against Ae. aegypti, through electronic database searches (Pubmed, Science Direct and Scielo), covering an overview of the plant sources ...
Source: Current Pharmaceutical Design - August 5, 2020 Category: Drugs & Pharmacology Authors: de Souza MA, da Silva L, Dos Santos MAC, Macêdo MJF, Lacerda-Neto LJ, Coutinho HDM, de Oliveira LCC, Cunha FAB Tags: Curr Pharm Des Source Type: research

Direct targets and subsequent pathways for molecular hydrogen to exert multiple functions: Focusing on interventions in radical reactions.
Abstract Molecular hydrogen (H2 ) was long regarded as non-functional in mammalian cells. We overturned the concept by demonstrating that H2 exhibits antioxidant effects and protects cells against oxidative stress. Subsequently, it has been revealed that H2 has multiple functions in addition to antioxidant effects, including ant-inflammatory, anti-allergic functions, and as a cell death and autophagy regulation. Additionally, H2 stimulates energy metabolism. Because H2 does not readily react with most biomolecules without a catalyst, it is essential to identify the primary targets with which H2 reacts or interacts...
Source: Current Pharmaceutical Design - August 5, 2020 Category: Drugs & Pharmacology Authors: Ohta S Tags: Curr Pharm Des Source Type: research

Role of Opioidergic System in Regulating Depression Pathophysiology.
CONCLUSION: The endogenous opioidergic system is intimately interwoven with MDD pathophysiology and provides a relevant target for novel treatment development, as well as providing a focus for the integration of wider MDD pathophysiology. PMID: 32767926 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 5, 2020 Category: Drugs & Pharmacology Authors: Anderson G, Maes M Tags: Curr Pharm Des Source Type: research

CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 5, 2020 Category: Drugs & Pharmacology Authors: Song C, Qi Y, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

Plasma non-cholesterol sterols as markers of cholesterol synthesis and intestinal absorption: a critical review.
o ECR Abstract Plasma concentrations of phytosterols, and of non-cholesterol sterol precursors of cholesterol synthesis have been used as markers, respectively, of intestinal cholesterol absorption and synthesis in inherited and secondary dyslipidemias and in population-based investigations to evaluate the risk for cardiovascular disease. The method aims at replacing initial research tecniques such as use of stable isotopes associated with fecal steroid balance that are limited by high cost and tedious procedures. However, we show in this review that several results obtained with serum sterol measurements are cont...
Source: Current Pharmaceutical Design - July 30, 2020 Category: Drugs & Pharmacology Authors: Quintão ECR Tags: Curr Pharm Des Source Type: research

Plant compounds for the treatment of diabetes, a metabolic disorder: NF- κB as therapeutic target.
CONCLUSION: NF-κB plays a crucial role in the development of diabetic complications because of its link in expression of genes that are responsible for organs damage such as kidney, brain, eye, liver, heart, muscle, endothelium, adipose tissue and pancreas by inflammation, apoptosis and oxidative stress. Activation of PPAR-α, SIRT3/1, and FXR through many cascades by plant compounds such as terpenoids, iridoids, flavonoids, alkaloids, phenols, tannins, carbohydrates, and phyto cannabinoids recover the diabetic complications. These compounds also exhibit prevention of NF-κB translocation into nucleus by in...
Source: Current Pharmaceutical Design - July 30, 2020 Category: Drugs & Pharmacology Authors: Sahukari R, Punabaka J, Bhasha S, Ganjikunta VS, Ramudu SK, Kesireddy SR Tags: Curr Pharm Des Source Type: research

Stem Cell Therapy Offers a Possible Safe and Promising Alternative Approach for Treating Vitiligo: A Review.
CONCLUSIONS: Finally, MSC therapy also has been shown to stimulate the mobilization of healthy melanocytes, leading to successful repigmentation of skin lesions in vitiligo patients. PMID: 32744962 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - July 30, 2020 Category: Drugs & Pharmacology Authors: Esquive D, Mishra R, Srivastava A Tags: Curr Pharm Des Source Type: research

Recent advances in strategies for extracellular matrix degradation and synthesis inhibition for improved therapy of solid tumors.
Abstract Despite a great deal of efforts made by researchers and the advances in the technology, the treatment of cancer is very challenging. Significant advances in the field of cancer therapeutics have been made but due to the complexity of solid tumor microenvironment, specially their dense extracellular matrix (which make the conditions favorable for cancer growth, metastasis and act as a barrier to the chemotherapeutic drugs as well as nanomedicine), the treatment of solid tumors is difficult. Overexpression of extracellular matrix components such as collagen, hyaluronan and proteoglycans in solid tumor leads...
Source: Current Pharmaceutical Design - July 28, 2020 Category: Drugs & Pharmacology Authors: Sandha KK, Shukla MK, Gupta PN Tags: Curr Pharm Des Source Type: research

An overview of the mechanisms of marine fungi-derived antiinflammatory and anti-tumor agents and their novel role in drug targeting.
Abstract Marine fungi with their successful pharmacological effects were considered to be the treasure of ocean medicines concerning the striking ability of their secondary metabolites. Literature over literature has been published on fungi derived bioactive molecules to probe its therapeutic potential. Marine fungi have an implicit to cede future medicines against life-threatening diseases, such as cancer and several emerging inflammations. The biological actions of many marine fungi-derived secondary metabolites are still unlocked, for an assorted number of bioactive compounds by which they interact with human d...
Source: Current Pharmaceutical Design - July 28, 2020 Category: Drugs & Pharmacology Authors: Shams Ul Hassan S, Ishaq M, Zhang WD, Jin HZ Tags: Curr Pharm Des Source Type: research

Fighting diabetes mellitus: Pharmacological and non-pharmacological approaches.
CONCLUSION: Pharmacological-based approaches such as insulin, metformin, sodium-glucose cotransporters 2 inhibitor, sulfonylureas, glucagon-like peptide-1 receptor agonists, and dipeptidyl peptidase IV inhibitors represent the most important strategies in diabetes management. These approved diabetes medications work via targeting the central signaling pathways related to the etiology of diabetes. Non-pharmacological approaches including dietary modification, increased physical activity, and microbiota-based therapy are the other cornerstones for diabetes treatment. Pharmacological-based approaches may be incorporated when ...
Source: Current Pharmaceutical Design - July 28, 2020 Category: Drugs & Pharmacology Authors: Wang X, Kang J, Liu Q, Tong T, Quan H Tags: Curr Pharm Des Source Type: research

Natural Products and Extracts as Xantine Oxidase Inhibitors - A Hope for Gout Disease?
Abstract Xanthine oxidase (EC 1.17.3.2) (XO) is one of the main enzymatic sources that create reactive oxygen species (ROS) in the living system. It is a dehydrogenase enzyme that performs electron transfer to nicotinamide adenine dinucleotide (NAD+ ), while oxidizing hypoxanthin, which is an intermediate compound in purine catabolism, first to xanthine and then to uric acid. XO turns into an oxidant enzyme that oxidizes thiol groups under certain stress conditions in the tissue. The last metabolic step, in which hypoxanthin turns into uric acid, is catalyzed by XO. Uric acid, considered a waste product, can cause...
Source: Current Pharmaceutical Design - July 28, 2020 Category: Drugs & Pharmacology Authors: Orhan IE, Deniz FSS Tags: Curr Pharm Des Source Type: research

Mechano-chemo-biological computational models for arteries in health, disease and healing: from tissue remodelling to drug-eluting devices.
Abstract This review aims to highlight urgent priorities for the computational biomechanics community in the framework of mechano-chemo-biological models. Recent approaches, promising directions and open challenges on the computational modelling of arterial tissues in health and disease are introduced and investigated, together with in silico approaches for the analysis of drug-eluting stents that promote a pharmacological-induced healing. The paper addresses a number of chemo-biological phenomena that are generally neglected in biomechanical engineering models but are most likely instrumental for the onset and th...
Source: Current Pharmaceutical Design - July 28, 2020 Category: Drugs & Pharmacology Authors: Marino M, Vairo G, Wriggers P Tags: Curr Pharm Des Source Type: research

Estimated arterial stiffness and prediction of vascular aging: The rising of a new era.
Abstract Arterial stiffness has been associated with cardiovascular events and correlated with cardiovascular risk factors. In the new guidelines of the European Society of Hypertension, the evaluation of arterial stiffness, and specifically carotid-femoral pulse wave velocity (c-f PWV), was taken into account for the detailed screening of the hypertensive population. Despite the importance of arterial stiffness as a target organ damage, the measurement is time-consuming, not practical, needs expensive equipment and experienced staff. For all these reasons, c-f PWV is not recommended for the everyday clinical prac...
Source: Current Pharmaceutical Design - July 28, 2020 Category: Drugs & Pharmacology Authors: Antza C, Doundoulakis I, Akrivos E, Stabouli S, Chrysaidou K, Gidaris D, Kotsis V Tags: Curr Pharm Des Source Type: research