Recent Advancements in Pharmaceutical Cocrystals, Preparation Methods and Their Applications
Curr Pharm Des. 2021 Apr 14. doi: 10.2174/1381612827666210415104411. Online ahead of print.ABSTRACTThe issue of poor aqueous solubility is a major hurdle in pharmaceutical dosage forms design. A large number of active molecules in the research and development pipeline are known to possess poor aqueous solubility and hence are not suitable for further development. Therefore, the pharmaceutical industry is continuously in search of techniques to tackle the issue of poor solubility. Cocrystallization has gained popularity as one such technique for the modulation of physicochemical properties of an active pharmaceutical ingred...
Source: Current Pharmaceutical Design - April 16, 2021 Category: Drugs & Pharmacology Authors: Deeksha Manchanda Arun Kumar Arun Nanda Source Type: research

Recent Advancements in Pharmaceutical Cocrystals, Preparation Methods and Their Applications
Curr Pharm Des. 2021 Apr 14. doi: 10.2174/1381612827666210415104411. Online ahead of print.ABSTRACTThe issue of poor aqueous solubility is a major hurdle in pharmaceutical dosage forms design. A large number of active molecules in the research and development pipeline are known to possess poor aqueous solubility and hence are not suitable for further development. Therefore, the pharmaceutical industry is continuously in search of techniques to tackle the issue of poor solubility. Cocrystallization has gained popularity as one such technique for the modulation of physicochemical properties of an active pharmaceutical ingred...
Source: Current Pharmaceutical Design - April 16, 2021 Category: Drugs & Pharmacology Authors: Deeksha Manchanda Arun Kumar Arun Nanda Source Type: research

New Antidiabetic Therapies: A Paradigm Shift in Type 2 Diabetes Management
Curr Pharm Des. 2021;27(8):1007. doi: 10.2174/138161282708210308141311.NO ABSTRACTPMID:33849410 | DOI:10.2174/138161282708210308141311 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 14, 2021 Category: Drugs & Pharmacology Authors: Theocharis Koufakis Niki Katsiki Kalliopi Kotsa Source Type: research

New Antidiabetic Therapies: A Paradigm Shift in Type 2 Diabetes Management
Curr Pharm Des. 2021;27(8):1007. doi: 10.2174/138161282708210308141311.NO ABSTRACTPMID:33849410 | DOI:10.2174/138161282708210308141311 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 14, 2021 Category: Drugs & Pharmacology Authors: Theocharis Koufakis Niki Katsiki Kalliopi Kotsa Source Type: research

New Antidiabetic Therapies: A Paradigm Shift in Type 2 Diabetes Management
Curr Pharm Des. 2021;27(8):1007. doi: 10.2174/138161282708210308141311.NO ABSTRACTPMID:33849410 | DOI:10.2174/138161282708210308141311 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 14, 2021 Category: Drugs & Pharmacology Authors: Theocharis Koufakis Niki Katsiki Kalliopi Kotsa Source Type: research

Genetic and Epigenetic Biomarkers For Diagnosis, Prognosis and Treatment Of Metabolic Syndrome
CONCLUSION: For the screening, diagnosis, and prognosis of metabolic syndrome and the prescription of personalized medicine, the DNA methylation biomarkers specify for subjects have been recognized as an ensuring tool. While these results are promising, further investigations are needed to unravel the complicated synergic association of the genome, epigenome and the situations related to metabolic pathology.PMID:33845722 | DOI:10.2174/1381612827666210412145915 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 13, 2021 Category: Drugs & Pharmacology Authors: Rosaria V Giglio Anca P Stoian Angelo M Patti Ali A Rizvi Vasily Sukhorukov Marcello Ciaccio Alexander Orekhov Manfredi Rizzo Source Type: research

Application of Bacterial Nanocellulose in the Cancer Drug Delivery: A Review
Curr Pharm Des. 2021 Apr 12. doi: 10.2174/1381612827666210412150445. Online ahead of print.ABSTRACTBacterial nanocellulose (BNC) is one of the natural biopolymers with unique features, the most important of which are nontoxicity, biocompatibility, high tensile profile, nanofiber structure, and purity. The current review aimed to summarize the latest development in BNC-based biomaterials in cancer drug delivery. The original articles were found by searching key databases including PubMed, Scopus, and Web of Scientific and using key terms such as "bacterial nanocellulose OR bacterial cellulose OR BNC" AND "can...
Source: Current Pharmaceutical Design - April 13, 2021 Category: Drugs & Pharmacology Authors: Mina Shahriari-Khalaji Maryam Zarkesh Zahra Nozhat Source Type: research

Genetic and Epigenetic Biomarkers For Diagnosis, Prognosis and Treatment Of Metabolic Syndrome
CONCLUSION: For the screening, diagnosis, and prognosis of metabolic syndrome and the prescription of personalized medicine, the DNA methylation biomarkers specify for subjects have been recognized as an ensuring tool. While these results are promising, further investigations are needed to unravel the complicated synergic association of the genome, epigenome and the situations related to metabolic pathology.PMID:33845722 | DOI:10.2174/1381612827666210412145915 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 13, 2021 Category: Drugs & Pharmacology Authors: Rosaria V Giglio Anca P Stoian Angelo M Patti Ali A Rizvi Vasily Sukhorukov Marcello Ciaccio Alexander Orekhov Manfredi Rizzo Source Type: research

Application of Bacterial Nanocellulose in the Cancer Drug Delivery: A Review
Curr Pharm Des. 2021 Apr 12. doi: 10.2174/1381612827666210412150445. Online ahead of print.ABSTRACTBacterial nanocellulose (BNC) is one of the natural biopolymers with unique features, the most important of which are nontoxicity, biocompatibility, high tensile profile, nanofiber structure, and purity. The current review aimed to summarize the latest development in BNC-based biomaterials in cancer drug delivery. The original articles were found by searching key databases including PubMed, Scopus, and Web of Scientific and using key terms such as "bacterial nanocellulose OR bacterial cellulose OR BNC" AND "can...
Source: Current Pharmaceutical Design - April 13, 2021 Category: Drugs & Pharmacology Authors: Mina Shahriari-Khalaji Maryam Zarkesh Zahra Nozhat Source Type: research

ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis
CONCLUSION: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.PMID:33823762 | DOI:10.2174/1381612827666210325105106 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Wen Xu Bei Wang Yuxuan Cai Jinlan Chen Xing Lv Chong Guo Chengfu Yuan Source Type: research

Osteogenic differentiation factors of multipotent mesenchymal stromal cells in the current understanding
CONCLUSION: It is concluded that it is necessary to move from studies focused of the effects of local genes to those taking multiple measurements of the gene-regulatory profile and the biomolecules critical for the implementation of numerous, incompletely studied osteogenic factors of endogenous and exogenous origin. Among the cornerstones of future (epi)genetic studies, whether osteomodulatory effects are realized through specific signaling pathways and/or whether cross-signaling with known genes drives the osteogenic differentiation of MSCs remain to be determined.PMID:33823770 | DOI:10.2174/1381612827666210406150027 (So...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Kristina А Yurova Elena S Melashchenko Olga G Khaziakhmatova Vladimir V Malashchenko Olga B Melashchenko Egor O Shunkin Igor K Norkin Pavel A Ivanov Igor A Khlusov Larisa S Litvinova Source Type: research

Clinical Use of Neurophysiological Biomarkers and Self-Assessment Scales to Predict and Monitor Treatment Response for Psychotic and Affective disorders
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406151447. Online ahead of print.ABSTRACTPsychoses and affective disorders are severe mental illnesses with a considerable negative effect on an individual and global scale. They are among the most damaging and socially significant diseases, which contribute to permanent disabilities for the patients. The aim of this review is to analyse the capacity of neuroscientific methods as tools to reform psychiatry into a biologically valid medical discipline. Furthermore, it will focus on the application of the translational approach towards the diagnostic and therapeutic pr...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Katrin Aryutova Drozdstoy St Stoyanov Sevdalina Kandilarova Anna Todeva-Radneva Stefan S Kostianev Source Type: research

Liposomes: An emerging approach for treatment of cancer
CONCLUSION: Liposomal targeting is a better emerging approach as an advanced drug delivery carrier with targeting ligands for anti-cancer agents.PMID:33823772 | DOI:10.2174/1381612827666210406141449 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Akhlesh K Jain Keerti Mishra Source Type: research

Torasemide in hypertension and heart failure: re-inventing loop diuretic therapy?
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406142933. Online ahead of print.ABSTRACTIn heart failure (HF) patients, current European Society of Cardiology (ESC) guidelines recommends the use of three loop diuretics (furosemide, torasemide, bumetanide) in order to reduce HF hospitalizations but also to improve symptoms and exercise capacity in patients with signs and/or symptoms of congestion. In addition, for the first time in hypertensive patients, European Society of Hypertension (ESH) guidelines recommend the use of torasemide. This review aimed to summarize the mode of action of loop diuretics, to present...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Athanasios Manolis Manolis Kallistratos Michael Doumas Source Type: research

Gender Disparities on Access to Care and Coronary Disease Management
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406144310. Online ahead of print.ABSTRACTMortality decline in women to a lesser extent than in men with coronary artery disease (CAD) has provoked a bigger interest in some already existing dilemmas and questions. Many studies carried out in the past three decades have remained without precise answers and with many challenges in the prevention, diagnosis, treatment and outcome of CAD in women. The meta-analysis and the systematic review conducted in the last years have offered novel approaches to understanding CAD gender disparities in access to care and coronary dis...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Zorana Vasiljevic-Pokrajcic Gordana Krljanac Ratko Lasica Marija Zdravkovic Sanja Stankovic Predrag Mitrovic Vladan Vukcevic Milika Asanin Source Type: research

ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis
CONCLUSION: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.PMID:33823762 | DOI:10.2174/1381612827666210325105106 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Wen Xu Bei Wang Yuxuan Cai Jinlan Chen Xing Lv Chong Guo Chengfu Yuan Source Type: research

Osteogenic differentiation factors of multipotent mesenchymal stromal cells in the current understanding
CONCLUSION: It is concluded that it is necessary to move from studies focused of the effects of local genes to those taking multiple measurements of the gene-regulatory profile and the biomolecules critical for the implementation of numerous, incompletely studied osteogenic factors of endogenous and exogenous origin. Among the cornerstones of future (epi)genetic studies, whether osteomodulatory effects are realized through specific signaling pathways and/or whether cross-signaling with known genes drives the osteogenic differentiation of MSCs remain to be determined.PMID:33823770 | DOI:10.2174/1381612827666210406150027 (So...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Kristina А Yurova Elena S Melashchenko Olga G Khaziakhmatova Vladimir V Malashchenko Olga B Melashchenko Egor O Shunkin Igor K Norkin Pavel A Ivanov Igor A Khlusov Larisa S Litvinova Source Type: research

Clinical Use of Neurophysiological Biomarkers and Self-Assessment Scales to Predict and Monitor Treatment Response for Psychotic and Affective disorders
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406151447. Online ahead of print.ABSTRACTPsychoses and affective disorders are severe mental illnesses with a considerable negative effect on an individual and global scale. They are among the most damaging and socially significant diseases, which contribute to permanent disabilities for the patients. The aim of this review is to analyse the capacity of neuroscientific methods as tools to reform psychiatry into a biologically valid medical discipline. Furthermore, it will focus on the application of the translational approach towards the diagnostic and therapeutic pr...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Katrin Aryutova Drozdstoy St Stoyanov Sevdalina Kandilarova Anna Todeva-Radneva Stefan S Kostianev Source Type: research

Liposomes: An emerging approach for treatment of cancer
CONCLUSION: Liposomal targeting is a better emerging approach as an advanced drug delivery carrier with targeting ligands for anti-cancer agents.PMID:33823772 | DOI:10.2174/1381612827666210406141449 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Akhlesh K Jain Keerti Mishra Source Type: research

Torasemide in hypertension and heart failure: re-inventing loop diuretic therapy?
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406142933. Online ahead of print.ABSTRACTIn heart failure (HF) patients, current European Society of Cardiology (ESC) guidelines recommends the use of three loop diuretics (furosemide, torasemide, bumetanide) in order to reduce HF hospitalizations but also to improve symptoms and exercise capacity in patients with signs and/or symptoms of congestion. In addition, for the first time in hypertensive patients, European Society of Hypertension (ESH) guidelines recommend the use of torasemide. This review aimed to summarize the mode of action of loop diuretics, to present...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Athanasios Manolis Manolis Kallistratos Michael Doumas Source Type: research

Gender Disparities on Access to Care and Coronary Disease Management
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406144310. Online ahead of print.ABSTRACTMortality decline in women to a lesser extent than in men with coronary artery disease (CAD) has provoked a bigger interest in some already existing dilemmas and questions. Many studies carried out in the past three decades have remained without precise answers and with many challenges in the prevention, diagnosis, treatment and outcome of CAD in women. The meta-analysis and the systematic review conducted in the last years have offered novel approaches to understanding CAD gender disparities in access to care and coronary dis...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Zorana Vasiljevic-Pokrajcic Gordana Krljanac Ratko Lasica Marija Zdravkovic Sanja Stankovic Predrag Mitrovic Vladan Vukcevic Milika Asanin Source Type: research

ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis
CONCLUSION: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.PMID:33823762 | DOI:10.2174/1381612827666210325105106 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Wen Xu Bei Wang Yuxuan Cai Jinlan Chen Xing Lv Chong Guo Chengfu Yuan Source Type: research

Osteogenic differentiation factors of multipotent mesenchymal stromal cells in the current understanding
CONCLUSION: It is concluded that it is necessary to move from studies focused of the effects of local genes to those taking multiple measurements of the gene-regulatory profile and the biomolecules critical for the implementation of numerous, incompletely studied osteogenic factors of endogenous and exogenous origin. Among the cornerstones of future (epi)genetic studies, whether osteomodulatory effects are realized through specific signaling pathways and/or whether cross-signaling with known genes drives the osteogenic differentiation of MSCs remain to be determined.PMID:33823770 | DOI:10.2174/1381612827666210406150027 (So...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Kristina А Yurova Elena S Melashchenko Olga G Khaziakhmatova Vladimir V Malashchenko Olga B Melashchenko Egor O Shunkin Igor K Norkin Pavel A Ivanov Igor A Khlusov Larisa S Litvinova Source Type: research

Clinical Use of Neurophysiological Biomarkers and Self-Assessment Scales to Predict and Monitor Treatment Response for Psychotic and Affective disorders
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406151447. Online ahead of print.ABSTRACTPsychoses and affective disorders are severe mental illnesses with a considerable negative effect on an individual and global scale. They are among the most damaging and socially significant diseases, which contribute to permanent disabilities for the patients. The aim of this review is to analyse the capacity of neuroscientific methods as tools to reform psychiatry into a biologically valid medical discipline. Furthermore, it will focus on the application of the translational approach towards the diagnostic and therapeutic pr...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Katrin Aryutova Drozdstoy St Stoyanov Sevdalina Kandilarova Anna Todeva-Radneva Stefan S Kostianev Source Type: research

Liposomes: An emerging approach for treatment of cancer
CONCLUSION: Liposomal targeting is a better emerging approach as an advanced drug delivery carrier with targeting ligands for anti-cancer agents.PMID:33823772 | DOI:10.2174/1381612827666210406141449 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Akhlesh K Jain Keerti Mishra Source Type: research

Torasemide in hypertension and heart failure: re-inventing loop diuretic therapy?
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406142933. Online ahead of print.ABSTRACTIn heart failure (HF) patients, current European Society of Cardiology (ESC) guidelines recommends the use of three loop diuretics (furosemide, torasemide, bumetanide) in order to reduce HF hospitalizations but also to improve symptoms and exercise capacity in patients with signs and/or symptoms of congestion. In addition, for the first time in hypertensive patients, European Society of Hypertension (ESH) guidelines recommend the use of torasemide. This review aimed to summarize the mode of action of loop diuretics, to present...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Athanasios Manolis Manolis Kallistratos Michael Doumas Source Type: research

Gender Disparities on Access to Care and Coronary Disease Management
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406144310. Online ahead of print.ABSTRACTMortality decline in women to a lesser extent than in men with coronary artery disease (CAD) has provoked a bigger interest in some already existing dilemmas and questions. Many studies carried out in the past three decades have remained without precise answers and with many challenges in the prevention, diagnosis, treatment and outcome of CAD in women. The meta-analysis and the systematic review conducted in the last years have offered novel approaches to understanding CAD gender disparities in access to care and coronary dis...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Zorana Vasiljevic-Pokrajcic Gordana Krljanac Ratko Lasica Marija Zdravkovic Sanja Stankovic Predrag Mitrovic Vladan Vukcevic Milika Asanin Source Type: research

ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis
CONCLUSION: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.PMID:33823762 | DOI:10.2174/1381612827666210325105106 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Wen Xu Bei Wang Yuxuan Cai Jinlan Chen Xing Lv Chong Guo Chengfu Yuan Source Type: research

Osteogenic differentiation factors of multipotent mesenchymal stromal cells in the current understanding
CONCLUSION: It is concluded that it is necessary to move from studies focused of the effects of local genes to those taking multiple measurements of the gene-regulatory profile and the biomolecules critical for the implementation of numerous, incompletely studied osteogenic factors of endogenous and exogenous origin. Among the cornerstones of future (epi)genetic studies, whether osteomodulatory effects are realized through specific signaling pathways and/or whether cross-signaling with known genes drives the osteogenic differentiation of MSCs remain to be determined.PMID:33823770 | DOI:10.2174/1381612827666210406150027 (So...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Kristina А Yurova Elena S Melashchenko Olga G Khaziakhmatova Vladimir V Malashchenko Olga B Melashchenko Egor O Shunkin Igor K Norkin Pavel A Ivanov Igor A Khlusov Larisa S Litvinova Source Type: research

Clinical Use of Neurophysiological Biomarkers and Self-Assessment Scales to Predict and Monitor Treatment Response for Psychotic and Affective disorders
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406151447. Online ahead of print.ABSTRACTPsychoses and affective disorders are severe mental illnesses with a considerable negative effect on an individual and global scale. They are among the most damaging and socially significant diseases, which contribute to permanent disabilities for the patients. The aim of this review is to analyse the capacity of neuroscientific methods as tools to reform psychiatry into a biologically valid medical discipline. Furthermore, it will focus on the application of the translational approach towards the diagnostic and therapeutic pr...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Katrin Aryutova Drozdstoy St Stoyanov Sevdalina Kandilarova Anna Todeva-Radneva Stefan S Kostianev Source Type: research

Liposomes: An emerging approach for treatment of cancer
CONCLUSION: Liposomal targeting is a better emerging approach as an advanced drug delivery carrier with targeting ligands for anti-cancer agents.PMID:33823772 | DOI:10.2174/1381612827666210406141449 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Akhlesh K Jain Keerti Mishra Source Type: research

Torasemide in hypertension and heart failure: re-inventing loop diuretic therapy?
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406142933. Online ahead of print.ABSTRACTIn heart failure (HF) patients, current European Society of Cardiology (ESC) guidelines recommends the use of three loop diuretics (furosemide, torasemide, bumetanide) in order to reduce HF hospitalizations but also to improve symptoms and exercise capacity in patients with signs and/or symptoms of congestion. In addition, for the first time in hypertensive patients, European Society of Hypertension (ESH) guidelines recommend the use of torasemide. This review aimed to summarize the mode of action of loop diuretics, to present...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Athanasios Manolis Manolis Kallistratos Michael Doumas Source Type: research

Gender Disparities on Access to Care and Coronary Disease Management
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406144310. Online ahead of print.ABSTRACTMortality decline in women to a lesser extent than in men with coronary artery disease (CAD) has provoked a bigger interest in some already existing dilemmas and questions. Many studies carried out in the past three decades have remained without precise answers and with many challenges in the prevention, diagnosis, treatment and outcome of CAD in women. The meta-analysis and the systematic review conducted in the last years have offered novel approaches to understanding CAD gender disparities in access to care and coronary dis...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Zorana Vasiljevic-Pokrajcic Gordana Krljanac Ratko Lasica Marija Zdravkovic Sanja Stankovic Predrag Mitrovic Vladan Vukcevic Milika Asanin Source Type: research

ADAMTS9-AS2: A functional long non-coding RNA in tumorigenesis
CONCLUSION: LncRNA ADAMTS9-AS2 can become a promising biomolecular marker and a therapeutic target for human cancer.PMID:33823762 | DOI:10.2174/1381612827666210325105106 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Wen Xu Bei Wang Yuxuan Cai Jinlan Chen Xing Lv Chong Guo Chengfu Yuan Source Type: research

Osteogenic differentiation factors of multipotent mesenchymal stromal cells in the current understanding
CONCLUSION: It is concluded that it is necessary to move from studies focused of the effects of local genes to those taking multiple measurements of the gene-regulatory profile and the biomolecules critical for the implementation of numerous, incompletely studied osteogenic factors of endogenous and exogenous origin. Among the cornerstones of future (epi)genetic studies, whether osteomodulatory effects are realized through specific signaling pathways and/or whether cross-signaling with known genes drives the osteogenic differentiation of MSCs remain to be determined.PMID:33823770 | DOI:10.2174/1381612827666210406150027 (So...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Kristina А Yurova Elena S Melashchenko Olga G Khaziakhmatova Vladimir V Malashchenko Olga B Melashchenko Egor O Shunkin Igor K Norkin Pavel A Ivanov Igor A Khlusov Larisa S Litvinova Source Type: research

Clinical Use of Neurophysiological Biomarkers and Self-Assessment Scales to Predict and Monitor Treatment Response for Psychotic and Affective disorders
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406151447. Online ahead of print.ABSTRACTPsychoses and affective disorders are severe mental illnesses with a considerable negative effect on an individual and global scale. They are among the most damaging and socially significant diseases, which contribute to permanent disabilities for the patients. The aim of this review is to analyse the capacity of neuroscientific methods as tools to reform psychiatry into a biologically valid medical discipline. Furthermore, it will focus on the application of the translational approach towards the diagnostic and therapeutic pr...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Katrin Aryutova Drozdstoy St Stoyanov Sevdalina Kandilarova Anna Todeva-Radneva Stefan S Kostianev Source Type: research

Liposomes: An emerging approach for treatment of cancer
CONCLUSION: Liposomal targeting is a better emerging approach as an advanced drug delivery carrier with targeting ligands for anti-cancer agents.PMID:33823772 | DOI:10.2174/1381612827666210406141449 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Akhlesh K Jain Keerti Mishra Source Type: research

Torasemide in hypertension and heart failure: re-inventing loop diuretic therapy?
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406142933. Online ahead of print.ABSTRACTIn heart failure (HF) patients, current European Society of Cardiology (ESC) guidelines recommends the use of three loop diuretics (furosemide, torasemide, bumetanide) in order to reduce HF hospitalizations but also to improve symptoms and exercise capacity in patients with signs and/or symptoms of congestion. In addition, for the first time in hypertensive patients, European Society of Hypertension (ESH) guidelines recommend the use of torasemide. This review aimed to summarize the mode of action of loop diuretics, to present...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Athanasios Manolis Manolis Kallistratos Michael Doumas Source Type: research

Gender Disparities on Access to Care and Coronary Disease Management
Curr Pharm Des. 2021 Apr 6. doi: 10.2174/1381612827666210406144310. Online ahead of print.ABSTRACTMortality decline in women to a lesser extent than in men with coronary artery disease (CAD) has provoked a bigger interest in some already existing dilemmas and questions. Many studies carried out in the past three decades have remained without precise answers and with many challenges in the prevention, diagnosis, treatment and outcome of CAD in women. The meta-analysis and the systematic review conducted in the last years have offered novel approaches to understanding CAD gender disparities in access to care and coronary dis...
Source: Current Pharmaceutical Design - April 7, 2021 Category: Drugs & Pharmacology Authors: Zorana Vasiljevic-Pokrajcic Gordana Krljanac Ratko Lasica Marija Zdravkovic Sanja Stankovic Predrag Mitrovic Vladan Vukcevic Milika Asanin Source Type: research

Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments
Curr Pharm Des. 2021 Mar 28. doi: 10.2174/1381612827666210329101335. Online ahead of print.ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and...
Source: Current Pharmaceutical Design - March 30, 2021 Category: Drugs & Pharmacology Authors: Yi Du Kaijun Li Wei Liu Ruitong Song Meifeng Luo Jianfeng He Xiaoyu Xu Xiaosheng Qu Source Type: research

Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments
Curr Pharm Des. 2021 Mar 28. doi: 10.2174/1381612827666210329101335. Online ahead of print.ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and...
Source: Current Pharmaceutical Design - March 30, 2021 Category: Drugs & Pharmacology Authors: Yi Du Kaijun Li Wei Liu Ruitong Song Meifeng Luo Jianfeng He Xiaoyu Xu Xiaosheng Qu Source Type: research

Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments
Curr Pharm Des. 2021 Mar 28. doi: 10.2174/1381612827666210329101335. Online ahead of print.ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and...
Source: Current Pharmaceutical Design - March 30, 2021 Category: Drugs & Pharmacology Authors: Yi Du Kaijun Li Wei Liu Ruitong Song Meifeng Luo Jianfeng He Xiaoyu Xu Xiaosheng Qu Source Type: research

Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments
Curr Pharm Des. 2021 Mar 28. doi: 10.2174/1381612827666210329101335. Online ahead of print.ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and...
Source: Current Pharmaceutical Design - March 30, 2021 Category: Drugs & Pharmacology Authors: Yi Du Kaijun Li Wei Liu Ruitong Song Meifeng Luo Jianfeng He Xiaoyu Xu Xiaosheng Qu Source Type: research

Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments
Curr Pharm Des. 2021 Mar 28. doi: 10.2174/1381612827666210329101335. Online ahead of print.ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and...
Source: Current Pharmaceutical Design - March 30, 2021 Category: Drugs & Pharmacology Authors: Yi Du Kaijun Li Wei Liu Ruitong Song Meifeng Luo Jianfeng He Xiaoyu Xu Xiaosheng Qu Source Type: research

Recent Advances in Neuromyelitis Optica Spectrum Disorder: Pathogenesis, Mechanisms and Potential Treatments
Curr Pharm Des. 2021 Mar 28. doi: 10.2174/1381612827666210329101335. Online ahead of print.ABSTRACTNeuromyelitis optica spectrum disorder (NMOSD) is an acute or subacute demyelinating disease that affects mainly the optic nerve and spinal cord. A major proportion of NMOSD cases have a relationship with autoimmunity to aquaporin 4 (AQP4) found on the central nervous system. NMOSD can occur repeatedly, causing symptoms such as decreased vision and weakness of limbs. The main goal of current therapy is to relieve acute symptoms and prevent recurrence of the disease. Without timely and appropriate treatment, the recurrence and...
Source: Current Pharmaceutical Design - March 30, 2021 Category: Drugs & Pharmacology Authors: Yi Du Kaijun Li Wei Liu Ruitong Song Meifeng Luo Jianfeng He Xiaoyu Xu Xiaosheng Qu Source Type: research

New Strategies from Natural Materials to Fight against Diet-induced Metabolic Disorders (Part - II)
Curr Pharm Des. 2021;27(6):761-762. doi: 10.2174/138161282706210222144912.ABSTRACTAccording to the global statistics, the incidence of metabolic syndrome (MetS), which is a multifactorial disease with multiple risk factors, has reached nearly one-quarter of the population, and poses a serious threat to public health. MetS is a cluster of conditions characterized by insulin resistance, hypertension, obesity, and cardiovascular-related risk factors. Various aspects, such as modern lifestyle (diet, sedentary behavior), aging and genes attribute to increasing the morbidity of MetS. While external interventions, prescribed drug...
Source: Current Pharmaceutical Design - March 24, 2021 Category: Drugs & Pharmacology Authors: Mallikarjuna Korivi Betty R Liu Source Type: research

New Strategies from Natural Materials to Fight against Diet-induced Metabolic Disorders (Part - II)
Curr Pharm Des. 2021;27(6):761-762. doi: 10.2174/138161282706210222144912.ABSTRACTAccording to the global statistics, the incidence of metabolic syndrome (MetS), which is a multifactorial disease with multiple risk factors, has reached nearly one-quarter of the population, and poses a serious threat to public health. MetS is a cluster of conditions characterized by insulin resistance, hypertension, obesity, and cardiovascular-related risk factors. Various aspects, such as modern lifestyle (diet, sedentary behavior), aging and genes attribute to increasing the morbidity of MetS. While external interventions, prescribed drug...
Source: Current Pharmaceutical Design - March 24, 2021 Category: Drugs & Pharmacology Authors: Mallikarjuna Korivi Betty R Liu Source Type: research

New Strategies from Natural Materials to Fight against Diet-induced Metabolic Disorders (Part - II)
Curr Pharm Des. 2021;27(6):761-762. doi: 10.2174/138161282706210222144912.ABSTRACTAccording to the global statistics, the incidence of metabolic syndrome (MetS), which is a multifactorial disease with multiple risk factors, has reached nearly one-quarter of the population, and poses a serious threat to public health. MetS is a cluster of conditions characterized by insulin resistance, hypertension, obesity, and cardiovascular-related risk factors. Various aspects, such as modern lifestyle (diet, sedentary behavior), aging and genes attribute to increasing the morbidity of MetS. While external interventions, prescribed drug...
Source: Current Pharmaceutical Design - March 24, 2021 Category: Drugs & Pharmacology Authors: Mallikarjuna Korivi Betty R Liu Source Type: research

New Strategies from Natural Materials to Fight against Diet-induced Metabolic Disorders (Part - II)
Curr Pharm Des. 2021;27(6):761-762. doi: 10.2174/138161282706210222144912.ABSTRACTAccording to the global statistics, the incidence of metabolic syndrome (MetS), which is a multifactorial disease with multiple risk factors, has reached nearly one-quarter of the population, and poses a serious threat to public health. MetS is a cluster of conditions characterized by insulin resistance, hypertension, obesity, and cardiovascular-related risk factors. Various aspects, such as modern lifestyle (diet, sedentary behavior), aging and genes attribute to increasing the morbidity of MetS. While external interventions, prescribed drug...
Source: Current Pharmaceutical Design - March 24, 2021 Category: Drugs & Pharmacology Authors: Mallikarjuna Korivi Betty R Liu Source Type: research

New Strategies from Natural Materials to Fight against Diet-induced Metabolic Disorders (Part - II)
Curr Pharm Des. 2021;27(6):761-762. doi: 10.2174/138161282706210222144912.ABSTRACTAccording to the global statistics, the incidence of metabolic syndrome (MetS), which is a multifactorial disease with multiple risk factors, has reached nearly one-quarter of the population, and poses a serious threat to public health. MetS is a cluster of conditions characterized by insulin resistance, hypertension, obesity, and cardiovascular-related risk factors. Various aspects, such as modern lifestyle (diet, sedentary behavior), aging and genes attribute to increasing the morbidity of MetS. While external interventions, prescribed drug...
Source: Current Pharmaceutical Design - March 24, 2021 Category: Drugs & Pharmacology Authors: Mallikarjuna Korivi Betty R Liu Source Type: research