The Role of Pharmaceutical Agents in the Alleviation of Male Infertility (Part-I)
Curr Pharm Des. 2021;27(23):2661-2664. doi: 10.2174/138161282723210806121224.NO ABSTRACTPMID:34525902 | DOI:10.2174/138161282723210806121224 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Sofikitis Athanasios Zahariou Fotios Dimitriadis Aris Kaltsas Source Type: research

Cardiovascular and Cardioprotective Agents in 2021
Curr Pharm Des. 2021;27(26):2915-2916. doi: 10.2174/138161282726210817124540.NO ABSTRACTPMID:34525903 | DOI:10.2174/138161282726210817124540 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Manfredi Rizzo Source Type: research

The Role of Pharmaceutical Agents in the Alleviation of Male Infertility (Part-II)
Curr Pharm Des. 2021;27(24):2747-2749. doi: 10.2174/138161282724210806145035.NO ABSTRACTPMID:34525917 | DOI:10.2174/138161282724210806145035 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Sofikitis Athanasios Zahariou Fotios Dimitriadis Aris Kaltsas Source Type: research

Implantable Microfluidic Device: An Epoch of Technology
Curr Pharm Des. 2021 Aug 25. doi: 10.2174/1381612827666210825114403. Online ahead of print.ABSTRACTImplantable microfluidic devices are milestones in developing devices that can either measure parameters like ocular pressure and blood glucose level or deliver various components for therapeutic needs or behavioral modification. Researchers are currently focusing on the miniaturization of almost all its tools for a better healthcare platform. Implantable microfluidic devices are a combination of various systems including, but not limited to, microfluidic platforms, reservoirs, sensors, and actuators, implanted inside the bod...
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Abey Joseph Arivazhagan Rajendran Akash Karthikeyan Baiju G Nair Source Type: research

The Role of Pharmaceutical Agents in the Alleviation of Male Infertility (Part-I)
Curr Pharm Des. 2021;27(23):2661-2664. doi: 10.2174/138161282723210806121224.NO ABSTRACTPMID:34525902 | DOI:10.2174/138161282723210806121224 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Sofikitis Athanasios Zahariou Fotios Dimitriadis Aris Kaltsas Source Type: research

Cardiovascular and Cardioprotective Agents in 2021
Curr Pharm Des. 2021;27(26):2915-2916. doi: 10.2174/138161282726210817124540.NO ABSTRACTPMID:34525903 | DOI:10.2174/138161282726210817124540 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Manfredi Rizzo Source Type: research

The Role of Pharmaceutical Agents in the Alleviation of Male Infertility (Part-II)
Curr Pharm Des. 2021;27(24):2747-2749. doi: 10.2174/138161282724210806145035.NO ABSTRACTPMID:34525917 | DOI:10.2174/138161282724210806145035 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Sofikitis Athanasios Zahariou Fotios Dimitriadis Aris Kaltsas Source Type: research

Implantable Microfluidic Device: An Epoch of Technology
Curr Pharm Des. 2021 Aug 25. doi: 10.2174/1381612827666210825114403. Online ahead of print.ABSTRACTImplantable microfluidic devices are milestones in developing devices that can either measure parameters like ocular pressure and blood glucose level or deliver various components for therapeutic needs or behavioral modification. Researchers are currently focusing on the miniaturization of almost all its tools for a better healthcare platform. Implantable microfluidic devices are a combination of various systems including, but not limited to, microfluidic platforms, reservoirs, sensors, and actuators, implanted inside the bod...
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Abey Joseph Arivazhagan Rajendran Akash Karthikeyan Baiju G Nair Source Type: research

The Role of Pharmaceutical Agents in the Alleviation of Male Infertility (Part-I)
Curr Pharm Des. 2021;27(23):2661-2664. doi: 10.2174/138161282723210806121224.NO ABSTRACTPMID:34525902 | DOI:10.2174/138161282723210806121224 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Sofikitis Athanasios Zahariou Fotios Dimitriadis Aris Kaltsas Source Type: research

Cardiovascular and Cardioprotective Agents in 2021
Curr Pharm Des. 2021;27(26):2915-2916. doi: 10.2174/138161282726210817124540.NO ABSTRACTPMID:34525903 | DOI:10.2174/138161282726210817124540 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Manfredi Rizzo Source Type: research

The Role of Pharmaceutical Agents in the Alleviation of Male Infertility (Part-II)
Curr Pharm Des. 2021;27(24):2747-2749. doi: 10.2174/138161282724210806145035.NO ABSTRACTPMID:34525917 | DOI:10.2174/138161282724210806145035 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Sofikitis Athanasios Zahariou Fotios Dimitriadis Aris Kaltsas Source Type: research

Implantable Microfluidic Device: An Epoch of Technology
Curr Pharm Des. 2021 Aug 25. doi: 10.2174/1381612827666210825114403. Online ahead of print.ABSTRACTImplantable microfluidic devices are milestones in developing devices that can either measure parameters like ocular pressure and blood glucose level or deliver various components for therapeutic needs or behavioral modification. Researchers are currently focusing on the miniaturization of almost all its tools for a better healthcare platform. Implantable microfluidic devices are a combination of various systems including, but not limited to, microfluidic platforms, reservoirs, sensors, and actuators, implanted inside the bod...
Source: Current Pharmaceutical Design - September 16, 2021 Category: Drugs & Pharmacology Authors: Abey Joseph Arivazhagan Rajendran Akash Karthikeyan Baiju G Nair Source Type: research

Essential oils as alternative promising anti-Candidal agents: progress and prospects
Curr Pharm Des. 2021 Sep 14. doi: 10.2174/1381612827666210914124344. Online ahead of print.ABSTRACTCandida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects as well as treatment costs are considered as major limitations for antifungal drugs. It has drawn scientists' attention to search for potential substitution and therapeutic reliable alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Essential oi...
Source: Current Pharmaceutical Design - September 15, 2021 Category: Drugs & Pharmacology Authors: Awad Shala Shweta Singh Saif Hameed M P Khurana Source Type: research

Essential oils as alternative promising anti-Candidal agents: progress and prospects
Curr Pharm Des. 2021 Sep 14. doi: 10.2174/1381612827666210914124344. Online ahead of print.ABSTRACTCandida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects as well as treatment costs are considered as major limitations for antifungal drugs. It has drawn scientists' attention to search for potential substitution and therapeutic reliable alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Essential oi...
Source: Current Pharmaceutical Design - September 15, 2021 Category: Drugs & Pharmacology Authors: Awad Shala Shweta Singh Saif Hameed M P Khurana Source Type: research

Therapies for RYR1-Related Myopathies: Where We Stand and the Perspectives
Curr Pharm Des. 2021 Sep 9. doi: 10.2174/1389201022666210910102516. Online ahead of print.ABSTRACTRyR1-related myopathies are a family of genetic neuromuscular diseases due to mutations in the RYR1 gene. No treatment exists for any of these myopathies today, which could change in the coming years with the growing number of studies dedicated to the pre-clinical assessment of various approaches, from pharmacological to gene therapy strategies, using the numerous models developed up to now. In addition, the first clinical trials for these rare diseases have just been completed or are being launched. We review the most recent ...
Source: Current Pharmaceutical Design - September 13, 2021 Category: Drugs & Pharmacology Authors: Mathilde Beaufils Lauriane Travard John Rendu Isabelle Marty Source Type: research

Overview of polyethylene glycol-based materials with a special focus on core-shell particles for drug delivery application
Curr Pharm Des. 2021 Sep 9. doi: 10.2174/1381612827666210910104333. Online ahead of print.ABSTRACTPolyethylene glycols (PEG) are water-soluble nonionic polymeric molecules. PEG and PEG-based materials are used for various important applications such as solvents, adhesives, adsorbents, drug delivery agents, tissue engineering scaffolds, etc. The coating of nanoparticles with PEG forms core-shell nanoparticles. The PEG-based core-shell nanoparticles are synthesized for the development of high-quality drug delivery systems. In the present review, we first explained the basics and various applications of PEGs and PEG-based com...
Source: Current Pharmaceutical Design - September 13, 2021 Category: Drugs & Pharmacology Authors: Nasrullah Shah Manzoor Hussain Touseef Rehan Abbas Khan Zubair Ullah Khan Source Type: research

Therapies for RYR1-Related Myopathies: Where We Stand and the Perspectives
Curr Pharm Des. 2021 Sep 9. doi: 10.2174/1389201022666210910102516. Online ahead of print.ABSTRACTRyR1-related myopathies are a family of genetic neuromuscular diseases due to mutations in the RYR1 gene. No treatment exists for any of these myopathies today, which could change in the coming years with the growing number of studies dedicated to the pre-clinical assessment of various approaches, from pharmacological to gene therapy strategies, using the numerous models developed up to now. In addition, the first clinical trials for these rare diseases have just been completed or are being launched. We review the most recent ...
Source: Current Pharmaceutical Design - September 13, 2021 Category: Drugs & Pharmacology Authors: Mathilde Beaufils Lauriane Travard John Rendu Isabelle Marty Source Type: research

Overview of polyethylene glycol-based materials with a special focus on core-shell particles for drug delivery application
Curr Pharm Des. 2021 Sep 9. doi: 10.2174/1381612827666210910104333. Online ahead of print.ABSTRACTPolyethylene glycols (PEG) are water-soluble nonionic polymeric molecules. PEG and PEG-based materials are used for various important applications such as solvents, adhesives, adsorbents, drug delivery agents, tissue engineering scaffolds, etc. The coating of nanoparticles with PEG forms core-shell nanoparticles. The PEG-based core-shell nanoparticles are synthesized for the development of high-quality drug delivery systems. In the present review, we first explained the basics and various applications of PEGs and PEG-based com...
Source: Current Pharmaceutical Design - September 13, 2021 Category: Drugs & Pharmacology Authors: Nasrullah Shah Manzoor Hussain Touseef Rehan Abbas Khan Zubair Ullah Khan Source Type: research

Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system
CONCLUSION: The results indicate the potential of OMV-NP as a novel vaccine delivery system.PMID:34493192 | DOI:10.2174/1381612827666210907154715 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 8, 2021 Category: Drugs & Pharmacology Authors: Abbas Rami Fatemeh Kazemi-Lomedasht Ali Mirjalili Mojtaba Noofeli Fereshteh Shahcheraghi Naser Mohammadpour Dounighi Source Type: research

Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system
CONCLUSION: The results indicate the potential of OMV-NP as a novel vaccine delivery system.PMID:34493192 | DOI:10.2174/1381612827666210907154715 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 8, 2021 Category: Drugs & Pharmacology Authors: Abbas Rami Fatemeh Kazemi-Lomedasht Ali Mirjalili Mojtaba Noofeli Fereshteh Shahcheraghi Naser Mohammadpour Dounighi Source Type: research

Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system
CONCLUSION: The results indicate the potential of OMV-NP as a novel vaccine delivery system.PMID:34493192 | DOI:10.2174/1381612827666210907154715 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 8, 2021 Category: Drugs & Pharmacology Authors: Abbas Rami Fatemeh Kazemi-Lomedasht Ali Mirjalili Mojtaba Noofeli Fereshteh Shahcheraghi Naser Mohammadpour Dounighi Source Type: research

Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system
CONCLUSION: The results indicate the potential of OMV-NP as a novel vaccine delivery system.PMID:34493192 | DOI:10.2174/1381612827666210907154715 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 8, 2021 Category: Drugs & Pharmacology Authors: Abbas Rami Fatemeh Kazemi-Lomedasht Ali Mirjalili Mojtaba Noofeli Fereshteh Shahcheraghi Naser Mohammadpour Dounighi Source Type: research

Outer Membrane Vesicles of Bordetella pertussis encapsulated into sodium alginate nanoparticles as novel vaccine delivery system
CONCLUSION: The results indicate the potential of OMV-NP as a novel vaccine delivery system.PMID:34493192 | DOI:10.2174/1381612827666210907154715 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 8, 2021 Category: Drugs & Pharmacology Authors: Abbas Rami Fatemeh Kazemi-Lomedasht Ali Mirjalili Mojtaba Noofeli Fereshteh Shahcheraghi Naser Mohammadpour Dounighi Source Type: research

Totally Implantable Venous Access Port Systems: Implant Depth-based Complications in Breast Cancer Therapy - A Comparative Study
This study reviewed the depth TIVAPS implantation in the internal jugular vein in 1282 breast cancer patients over a ten-year period (2009-2019), and associated complications. We segregated the patients as 5 groups: 'Group A (depth 16 mm)'. Consequently, the 'internal complications' such as infection, venous thrombotic syndrome, catheter folding & migration, extravasation, whereas the 'external complications' viz., inflammation, local hematoma, local cutaneous reactions, and port exteriorization were significantly analyzed during TIVAPS implantation at different depths in BC patients.RESULTS: Overall incidence of 'inte...
Source: Current Pharmaceutical Design - September 7, 2021 Category: Drugs & Pharmacology Authors: Kuo Chen Narasimha M Beeraka Yuanting Gu Jingruo Li Mikhail Sinelnikov Nan Han Pengwei Lu Source Type: research

Covid-19 And Rheumatic Autoimmune Systemic Diseases: Role of Pre-Existing Lung Involvement and Ongoing Treatments
CONCLUSION: The higher prevalence of Covid-19 in ASD patients along with the significant correlations with important clinical features and therapeutic regimens suggests the need to develop targeted prevention/management strategies during the current pandemic wave.PMID:34477509 | DOI:10.2174/1381612827666210903103935 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 3, 2021 Category: Drugs & Pharmacology Authors: Clodoveo Ferri Dilia Giuggioli Vincenzo Raimondo Massimo L'Andolina Lorenzo Dagna Antonio Tavoni Francesco Caso Francesco Ursini Ruscitti Piero Maurizio Caminiti Rosario Foti Valeria Riccieri Serena Guiducci Roberta Pellegrini Elisabetta Zanatta Giuseppe Source Type: research

Ryanodine receptor as insecticide target
Curr Pharm Des. 2021 Sep 2. doi: 10.2174/1381612827666210902150224. Online ahead of print.ABSTRACTRyanodine receptor (RyR) is one of the primary targets of commercial insecticides. The diamide insecticide family, including flubendiamide, chlorantraniliprole, cyantraniliprole, etc, targets insect RyRs and can be used to control a wide range of destructive agricultural pests. The diamide insecticides are highly selective against lepidopteran and coleopteran pests with relatively low toxicity for non-target species, such as mammals, fishes, and beneficial insects. However, recently mutations identified on insect RyRs have eme...
Source: Current Pharmaceutical Design - September 3, 2021 Category: Drugs & Pharmacology Authors: Arthur Samurkas Li Yao Hadiatullah Hadiatullah Ruifang Ma Yunxun Xie Rajamanikandan Sundarraj Han Zuilhof Zhiguang Yuchi Source Type: research

Surgical Treatment of Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension
Curr Pharm Des. 2021 Sep 2. doi: 10.2174/1381612827666210902152539. Online ahead of print.ABSTRACTVenous thromboembolism clinically presents as deep venous thrombosis or acute pulmonary embolism and is globally recognized as the third most frequent acute cardiovascular syndrome after myocardial infarction and stroke. Although pulmonary embolism does not typically cause severe pulmonary hypertension in the acute setting, thrombus organization and fibrosis can lead to stenosis or obliteration of pulmonary arteries in a minority of patients, which in turn result in severe pulmonary hypertension and right heart failure. This d...
Source: Current Pharmaceutical Design - September 3, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Papakonstantinou Polydoros Kampaktsis Filippos-Paschalis Rorris Ilias Doulamis Aspasia Tzani Sotirios Katsaridis Dimitrios Avgerinos Source Type: research

sFlt-1: a double regulator in angiogenesis-related diseases
CONCLUSION: From the summary article, sFlt-1 is a double regulator in angiogenesis-related diseases; too much or too little may cause different diseases. Therefore, maintaining the stability of sFlt-1 content in the body is essential to control the development of related diseases.PMID:34477512 | DOI:10.2174/1381612827666210902155015 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 3, 2021 Category: Drugs & Pharmacology Authors: Li Liao Xingtao Zhao Mengting Zhou Ying Deng Yunxia Li Cheng Peng Source Type: research

Assessment of combination approaches of phytoconstituents with chemotherapy for the treatment of breast cancer, a systematic review
CONCLUSION: The combination approaches of phytoconstituents with chemotherapeutic drugs give less toxicity to normal cells, reduce side effects, and overcome the multi-drug resistance, making the combination approaches an effective strategy.PMID:34477513 | DOI:10.2174/1381612827666210902155752 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 3, 2021 Category: Drugs & Pharmacology Authors: Ali Sartaj Sanjula Baboota Javed Ali Source Type: research

Anticholinergic Exposure in Elderly Complex Chronic Patients: A Cross-Sectional Study
CONCLUSIONS: This study has highlighted clear differences between the scales used. DBI seems to be the scale that identifies a higher number of elderly chronic complex patients at risk of developing anticholinergic adverse effects.PMID:34463225 | DOI:10.2174/1381612827666210830164054 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 31, 2021 Category: Drugs & Pharmacology Authors: Ángela Tristancho-Pérez Ángela Villalba-Moreno Mar ía Dolores Santos-Rubio Mar ía Dolores López-Malo Bernardo Santos-Ramos Susana S ánchez-Fidalgo Source Type: research

Upregulated Long Non-coding RNA ALMS1-IT1 Promotes Neuroinflammation by Activating NF- κB Signaling in Ischemic Cerebral Injury
CONCLUSIONS: These data demonstrated that ALMS1-IT1 inhibition improved neurological function of MCAO rats, at least in part by repressing NF-κB-dependent neuro-inflammation.PMID:34455967 | DOI:10.2174/1381612827666210827104316 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Peng Lu Ye Zhang Huanjiang Niu Yirong Wang Source Type: research

LncRNA PCGsEM1 contributes to the Proliferation, Migration and Invasion of Non-small Cell Lung Cancer Cells via acting as a Sponge for miR-152-3p Short title: The PCGEM1/miR-152-3p axis in NSCLC
Curr Pharm Des. 2021 Aug 26. doi: 10.2174/1381612827666210827104828. Online ahead of print.ABSTRACTBACKGROUND: Long non-coding RNAs (lncRNAs) have been reported to play important roles in cellular biological function. Aberrant expression of lncRNAs has been found to be related to the progression of various diseases. LncRNA prostate cancer gene expression marker 1 (PCGEM1) has been demonstrated to be involved in the initiation and progression of human cancers. However, to date, the clinical and functional significance of PCGEM1 expression in NSCLC progression remains unknown.METHODS: The expression of LncRNA PCGEM1 and miR-...
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Jianhui Huang Jian Lou Xueni Liu Yanru Xie Source Type: research

Nanotechnology-Based Strategies for the Management of COVID-19: Recent Development and Challenges
Curr Pharm Des. 2021 Aug 29. doi: 10.2174/1381612827666210830105459. Online ahead of print.ABSTRACTCOVID-19 is a respiratory disease caused by a newly identified coronavirus named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Since its inception in late December 2019, COVID-19 has led to a remarkable loss of human life all over the world. To overcome the unprecedented challenges posed by COVID-19 pandemic to the public and economic health, strengthening of the healthcare system is utmost needed. In this regard, research communities are putting efforts in developing an advanced healthcare system, that cou...
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Ritu Singh Monalisha Behera Nisha Kumari Sanjeev Kumar Vishnu D Rajput Tatiana M Minkina Mohd Adnan Arif Jamal Siddiqui Narendra Kumar Source Type: research

The Regulatory Role of Both MBNL1 and MBNL1-AS1 in Several Common Cancers
CONCLUSION: MBNL1 may be an important regulator of cancer, and MBNL1-AS1 is a better tumor suppressor.PMID:34459372 | DOI:10.2174/1381612827666210830110732 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Qi Zhang Yinxin Wu Jinlan Chen Yuxuan Cai Bei Wang Fangshun Tan Jie Mou Chengfu Yuan Source Type: research

Hypertension in pregnancy: unanswered questions
Curr Pharm Des. 2021 Aug 29. doi: 10.2174/1381612827666210830091652. Online ahead of print.ABSTRACTBACKGROUND: Hypertension of pregnancy [office blood pressure (BP) levels≥140/90 mmHg] is fairly common and can affect up to 10% of pregnant women worldwide. Hypertension of pregnancy is an important risk factor for the mother and carries increased morbidity and mortality for the fetus. Women with hypertension of pregnancy have a high-risk for future cardiovascular and renal events.OBJECTIVES: To summarize the literature related to several clinical aspects of hypertension in pregnancy and draw clinically meaningful conclusi...
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Vasilios Papademetriou Konstantinos Stavropoulos Dimitrios Patoulias Christodoulos Papadopoulos Kerpiniotis Georgios Maria Toumpourleka Alexandros Sachinidis Source Type: research

Multi-functionalization, a promising adaptation to overcome challenges to clinical translation of nanomedicines as nano-diagnostics and nano-therapeutics for breast cancer
CONCLUSION: Critical analysis of the available evidences revealed that multi-functionalization of nanomedicines is a plausible and sustainable adaptation for early diagnosis and treatment of BC with better therapeutic outcomes.PMID:34459374 | DOI:10.2174/1381612827666210830092539 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Lama Abdulrahim Abdul Moti Zahid Hussain Hnin Ei Thu Shahzeb Khan Mohammad Sohail Rai Muhammad Sarfraz Source Type: research

The Use of Lectins as Tools to Combat SARS-CoV-2
CONCLUSION: even with the development of effective vaccines, new cases of viral infection with the same virus, or new outbreaks with different viruses can occur; so, the development of new treatments should not be discarded. moreover, the discussions made in this work are relevant regarding the anti-viral properties of lectins.PMID:34459375 | DOI:10.2174/1381612827666210830094743 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Daniela Martinez Diego Amaral David Markovitz Luciano Pinto Source Type: research

The Relation between the Plasma Concentrations of Long-Acting Atypical Antipsychotics and Clinical Effectiveness in Patients Affected by Schizophrenia or Schizoaffective Disorder: A Comprehensive Overview
Curr Pharm Des. 2021 Aug 29. doi: 10.2174/1381612827666210830095349. Online ahead of print.ABSTRACTAtypical antipsychotic depot medications are currently recommended for patients with schizophrenia (SCZ) to prevent relapse and ameliorate the long-term prognosis of these patients. This review critically summarizes the available data about the association between the plasma concentrations of long-acting SecondGeneration Antipsychotics (SGAs) and the clinical effectiveness of these compounds in patients affected by SCZ or schizoaffective disorder. Our question is if the measurement of these concentrations can be helpful for c...
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Enrico Capuzzi Alessandro Ceresa Alice Caldiroli Cecilia Maria Esposito Paolo Ossola Massimiliano Buoli Source Type: research

Multivesicular liposome: A lipid-based drug delivery system for efficient drug delivery
Curr Pharm Des. 2021 Aug 29. doi: 10.2174/1381612827666210830095941. Online ahead of print.ABSTRACTThe advancement of delivery tools for therapeutic agents has brought several novel formulations with increased drug loading, sustained release, targeted delivery, and prolonged efficacy. Amongst the several novel delivery approaches, multivesicular liposome has gained potential interest because this delivery system possesses the above advantages. In addition, this multivesicular liposomal delivery prevents degradation of the entrapped drug within the physiological environment while administered. The special structure of the v...
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Bapi Gorain Bandar E Al-Dhubiab Anroop Nair Prashant Kesharwani Manisha Pandey Hira Choudhury Source Type: research

Perfluorocarbons therapeutics in modern cancer nanotechnology for hypoxia-induced anti-tumor therapy
Curr Pharm Des. 2021 Aug 29. doi: 10.2174/1381612827666210830100907. Online ahead of print.ABSTRACTWith an estimated failure rate of about 90%, immunotherapies that are intended for the treatment of solid tumors have caused an anomalous rise in the mortality rate over the past decades. It is apparent that resistance towards such therapies primarily occurs due to elevated levels of HIF-1 (Hypoxia-induced factor) in tumor cells, which are caused by disrupted microcirculation and diffusion mechanisms. With the advent of nanotechnology, several innovative advances were brought to the fore; and, one such promising direction is ...
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Saurabh Satija Prabal Sharma Harpreet Kaur Daljeet Singh Dhanjal Reena Singh Chopra Navneet Khurana Manish Vyas Neha Sharma Murtaza M Tambuwala Hamid A Bakshi Nitin B Charbe Flavia C Zacconi Dinesh Kumar Chellappan Kamal Dua Meenu Mehta Source Type: research

Venous Thromboembolism in Patients with Heart Failure
Curr Pharm Des. 2021 Aug 29. doi: 10.2174/1381612827666210830102419. Online ahead of print.ABSTRACTHeart failure (HF) and venous thromboembolism (VTE) are common clinical entities, closely inter-related, sharing multiple pathophysiological mechanisms. Their co-incidence is associated with further worsening of the prognosis of one another. Despite their frequent co-existence, important clinical questions still remain unanswered. The risk of VTE especially in chronic HF patients appears to vary widely in clinical studies, while the VTE-associated risk in HF pa-tients is still not well determined and cannot be accurately pred...
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Aris Bechlioulis Lampros Lakkas Aidonis Rammos Christos Katsouras Lampros Michalis Katerina Naka Source Type: research

Matrixmetalloproteinase Inhibitors: Promising Therapeutic Targets Against Cancer
CONCLUSION: In this review, we presented different MMP inhibitors, their performance at different stages of models - in vitro, in vivo, small animal models and eventually clinical trials. We provide newer methods of MMPI delivery that may be better targeted to suppress only specific MMPs and avoid toxic side-effects in healthy cells.PMID:34459380 | DOI:10.2174/1381612827666210830103059 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 30, 2021 Category: Drugs & Pharmacology Authors: Vibha Rani Dhananjay Yadav Neha Atale Source Type: research

Nanoscience
Curr Pharm Des. 2021;27(21):2435. doi: 10.2174/138161282721210628122958.NO ABSTRACTPMID:34414863 | DOI:10.2174/138161282721210628122958 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Jaiprakash N Sangshetti Source Type: research

Oncology
Curr Pharm Des. 2021;27(20):2327. doi: 10.2174/138161282720210628113005.NO ABSTRACTPMID:34414866 | DOI:10.2174/138161282720210628113005 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Jen-Tsung Chen Source Type: research

The therapeutic value and molecular mechanisms of lncRNA FENDRR in human cancer
CONCLUSION: Specific evidences for the involvement of LncRNA FENDRR in cancer regulatory processes suggest that FENDRR has the potential to be a biomarker or clinical therapeutic target for malignant tumors.PMID:34414867 | DOI:10.2174/1381612827666210820094702 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Wen Xu Bei Wang Yuxuan Cai Jinlan Chen Enqing Meng Chong Guo Gang Zhou Chengfu Yuan Source Type: research

Transdermal Delivery Of Macromolecules Using Nanolipid Carriers
Curr Pharm Des. 2021 Aug 19. doi: 10.2174/1381612827666210820095330. Online ahead of print.ABSTRACTSkin being the largest external organ, offers an enticing procedure for transdermal drug delivery, so the drug needs to rise above the outermost layer of the skin, i.e., stratum corneum. Small molecular drug entities obeying the Lipinski rule, i.e., drugs having a molecular weight less than 500Da, high lipophilicity, and optimum polarity, are favored enough to be used on the skin as therapeutics. Skin's barrier action properties prevent the transport of macromolecules at pre-determined therapeutic rates. Notable advancement i...
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Sana Kalave Bappaditya Chatterjee Parth Shah Ambikanandan Misra Source Type: research

A Recent Update on Intranasal Delivery of High Molecular Weight Proteins, Peptides, and Hormones
Curr Pharm Des. 2021 Aug 19. doi: 10.2174/1381612827666210820100723. Online ahead of print.ABSTRACTProteins and hormones have a wide range of therapeutic uses that have emerged throughout the years. The increase in their clinical application nowadays have outgrown the need to deliver these macromolecules without deterioration and ease of administration, therefore nasal delivery has proven to be the most useful tool. Despite the obstacles, smart polymers, nasal enhancers, nanotechnology-based delivery systems, and computational modelling tools have all been used to increase the residence time and absorption window in the na...
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Mayank Sharma Simran Waghela Riddhi Mhatre Gaurav K Saraogi Source Type: research

Nanoscience
Curr Pharm Des. 2021;27(21):2435. doi: 10.2174/138161282721210628122958.NO ABSTRACTPMID:34414863 | DOI:10.2174/138161282721210628122958 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Jaiprakash N Sangshetti Source Type: research

Oncology
Curr Pharm Des. 2021;27(20):2327. doi: 10.2174/138161282720210628113005.NO ABSTRACTPMID:34414866 | DOI:10.2174/138161282720210628113005 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Jen-Tsung Chen Source Type: research

The therapeutic value and molecular mechanisms of lncRNA FENDRR in human cancer
CONCLUSION: Specific evidences for the involvement of LncRNA FENDRR in cancer regulatory processes suggest that FENDRR has the potential to be a biomarker or clinical therapeutic target for malignant tumors.PMID:34414867 | DOI:10.2174/1381612827666210820094702 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 20, 2021 Category: Drugs & Pharmacology Authors: Wen Xu Bei Wang Yuxuan Cai Jinlan Chen Enqing Meng Chong Guo Gang Zhou Chengfu Yuan Source Type: research