3D Printing Methods for Pharmaceutical Manufacturing: Opportunity and Challenges.
CONCLUSION: 3D printing is revolutionizing the pharma expectations towards customized medicines but still there is a need to explore the aspects of cost, flexibility and bioequivalence. The present review provides a comprehensive account of various 3D printing technologies and highlights the opportunities and key challenges of 3D printing relevant to pharmaceuticals. PMID: 30520367 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 6, 2018 Category: Drugs & Pharmacology Authors: Warsi MH, Yusuf M, Al Robaian M, Khan M, Alsaab H, Muheem A, Khan S Tags: Curr Pharm Des Source Type: research

3D printing Technology in drug delivery: Recent progress and Application.
CONCLUSION: There is enormous scope for this promising technology in designing various delivery systems and provide customized patient compatible formulations with polypills. The future of this technology will rely on its prospective to provide 3D printing systems capable of manufacturing personalized doses. In nutshell, the 3D approach is likely to revolutionize drug delivery systems to a new level, though need time to evolve. PMID: 30520368 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 6, 2018 Category: Drugs & Pharmacology Authors: Kotta S, Nair A, Alsabeelah N Tags: Curr Pharm Des Source Type: research

A critical review on 3D-printed dosage forms.
CONCLUSION: The current status of 3D-printing as a manufacturing process for pharmaceutical dosage forms was highlighted in this review article. Moreover, this article presents a critical evaluation of 3D-printing to control the dose and drug release of printed dosage forms. PMID: 30520369 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 6, 2018 Category: Drugs & Pharmacology Authors: El Aita I, Ponsar H, Quodbach J Tags: Curr Pharm Des Source Type: research

The Applications of 3d Printing in Pulmonary Drug Delivery and Treatment of Respiratory Disorders.
CONCLUSION: The intension of this review is to detail our current understanding of the applications of 3D printing in the design and evaluation of inhalable medicines and to provide an overview on its application in the diagnosis and treatment of pulmonary diseases. This review also discusses other technical and regulatory challenges associated with the progression of 3D printing into clinical practice. PMID: 30520370 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 6, 2018 Category: Drugs & Pharmacology Authors: Haque S, Shadab M, Whittaker M, Kaminskas LM Tags: Curr Pharm Des Source Type: research

Treatment of early vascular ageing.
Abstract Artery disease can be identified from ankle-brachial index (peripheral artery disease), pulse wave velocity (arterial stiffness), carotid intima media thickness (atherosclerosis) and flow-mediated dilation (endothelial disfunction). Arterial stiffness is a marker of cardiovascular disease associated with cardiovascular events. Increased vascular ageing is the acceleration of arterial stiffness inappropriate for the given chronological age. Treatment of early vascular ageing seems to be important if we target on primary cardiovascular prevention. Known factors that postpone the progression of vascular age...
Source: Current Pharmaceutical Design - December 4, 2018 Category: Drugs & Pharmacology Authors: Antza C, Doundoulakis I, Natsis M, Kotsis V Tags: Curr Pharm Des Source Type: research

Patient-specific finite element model of coronary artery stenting.
CONCLUSIONS: The results may have implications not only for understanding the vulnerable plaques and arterial layers to rupture during the stenting, but also for providing a comprehensive information for the medical and biomechanical experts in interventions and surgeries, including balloon-angioplasty, bypass, and stenting. PMID: 30514186 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 3, 2018 Category: Drugs & Pharmacology Authors: Razaghi R, Karimi A, Taheri RA Tags: Curr Pharm Des Source Type: research

Treatment of hypertension induced albuminuria.
Abstract Regardless of having similar antihypertensive effect, different antihypertensive drug classes have different effect on albuminuria.Patients with albuminuria will usually need more than one drug to achieve blood pressure control, particularly if the aim is also to reduce albuminuria.Albuminuria is independently associated with cardiovascular and renal risk regardless of diabetes status. The recent ESC/ESH guidelines listed microalbuminuria among the hypertension-mediated organ damages. Albumin-to-creatinine ratio was suggested to be included in the routine workup for evaluation of every hypertensive patien...
Source: Current Pharmaceutical Design - November 26, 2018 Category: Drugs & Pharmacology Authors: Knežević T, Gellineo L, Jelaković A, Premužić V, Dika Ž, Laganović M, Jelaković B Tags: Curr Pharm Des Source Type: research

Treatment of Hypertension Induced Target Organ Damage in Children and Adolescents.
Abstract High blood pressure in children and adolescents may have adverse impact on the heart, the vessels, the kidney, and the central nervous system causing early functional or structural changes. The most prevalent subclinical hypertensive target organ damage in children and adolescents is left ventricular hypertrophy, and echocardiographic assessment of left ventricular mass is suggested in all hypertensive children. There is evolving evidence that antihypertensive treatment in children and adolescents could lead to regression of target organ damage, emphasizing also the importance of adequate blood pressure c...
Source: Current Pharmaceutical Design - November 26, 2018 Category: Drugs & Pharmacology Authors: Chrysaidou K, Stabouli S Tags: Curr Pharm Des Source Type: research

Treatment of hypertension to prevent atrial fibrillation.
Abstract Atrial fibrillation (AF) and hypertension (HT) are expected to rapidly rise worldwide in the next few years. Important improvements in AF therapy are hampered by pro-arrhythmic and bleeding risks of current medications. Prevention of AF is an important matter as it will not only prevent the disease but also medications side effects, and it is likely to be cost effective. HT is a major contributor to AF. As a modifiable risk factor, its treatment might reduce new-onset AF, and recurrent AF after cardioversion or ablation as well. We review here the effect of HT treatment to prevent AF. Renin-angiotensin sy...
Source: Current Pharmaceutical Design - November 26, 2018 Category: Drugs & Pharmacology Authors: De Becker B, De Borne Philippe V Tags: Curr Pharm Des Source Type: research

pNitro-Tyr-PseAAC: Predict nitrotyrosine sites in proteins by incorporating five features into Chou's general PseAAC.
CONCLUSION: It is concluded that the proposed computational model provides the foundation for further investigation and be used for the identification of nitrotyrosine sites in proteins. PMID: 30479209 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 26, 2018 Category: Drugs & Pharmacology Authors: Ghauri AW, Khan YD, Rasool N, Khan SA, Chou KC Tags: Curr Pharm Des Source Type: research

Pituitary adenylyl cyclase activating polypeptide (PACAP) signaling and the cell cycle machinery in neurodegenerative diseases.
Abstract Pituitary adenylyl cyclase activating polypeptide (PACAP) is a neuropeptide with great neuroprotective effects and remarkable therapeutic potential. PACAP activates several cellular pathways to exert its protective effects. Emerging evidence shows that PACAP can modify the levels and activity of cell cycle components involved in neurodegeneration to protect neurons from death. Cell cycle is a highly-regulated process that controls the balance between proliferation, differentiation and death of every cell in the body. Aberrant expression and function of components of the cell cycle machinery have been link...
Source: Current Pharmaceutical Design - November 26, 2018 Category: Drugs & Pharmacology Authors: Polanco MJ, Pennuto M Tags: Curr Pharm Des Source Type: research

The Organochalcogen Compound (MeOPhSe)2 Inhibits Both Formation and the Viability of the Biofilm Produced by Candida albicans, at Different Stages of Development.
CONCLUSION: Taken together, these results demonstrated the potential of the organochalcogen compound (MeOPhSe)2 as a promising antifungal therapy. PMID: 30465492 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 20, 2018 Category: Drugs & Pharmacology Authors: de Amorim LMM, Braga MT, Carvalho MSL, de Oliveira IR, Querobino SM, Alberto-Silva C, da Rocha JBT, Costa MS Tags: Curr Pharm Des Source Type: research

The role of calcium handling mechanisms in reperfusion injury.
Abstract Cardiovascular diseases, such as stroke and myocardial infarction (MI) remain the major cause of death and disability worldwide. However, the mortality of MI has declined dramatically over the past several decades because of advances in medicines (thrombolytic agents, antiplatelet drugs, beta blockers, and angiotensin converting enzyme inhibitors) and approaches to restore tissue perfusion(percutaneous coronary intervention and cardiopulmonary bypass). Animals studies have been shown that these treatments have been effective in reducing acute myocardial ischemic injury and limiting MI size. The paradox is...
Source: Current Pharmaceutical Design - November 20, 2018 Category: Drugs & Pharmacology Authors: Pittas K, Vrachatis DA, Angelidis C, Tsoucala S, Giannopoulos G, Defteros S Tags: Curr Pharm Des Source Type: research

Progresses in microRNA Delivery Using Synthetic Nanovectors for Cancer Therapy.
Abstract MicroRNAs are small noncoding RNAs that have key roles in gene expression. In recent decades, it has been revealed that aberrant expression of microRNAs is related to abnormality in gene expression and it is believed that they have potential to be used as anti-cancer drugs. However, the delivery of these small molecules is limited due to some obstacles including low uptake and insufficient endosomal release, intracellular nucleases degradation, phagocytic elimination and renal filtration. To overcome these issues, there are many novel delivery systems developed to improve efficiency of microRNAs therapy r...
Source: Current Pharmaceutical Design - November 20, 2018 Category: Drugs & Pharmacology Authors: Javanmardi S, Aghamaali MR, Abolmaali SS, Tamaddon AM Tags: Curr Pharm Des Source Type: research

Advanced carbon-based nanoplatforms combining drug delivery and thermal therapy for cancer treatment.
Abstract Anticancer treatment has become a research highlight in recent years. Despite several techniques have been developed and applied in the clinic, this area still meets great challenges in the construction of smart anticancer devices with accurate targeting, controlled release and microenvironment response properties. Most of carbon-based materials are biocompatible, possessing abundant and tunable pore structures and particularly large surface areas. These properties make them suitable materials as drug carriers. In addition, some carbon-based materials are capable of absorbing near-infrared radiation (NIR)...
Source: Current Pharmaceutical Design - November 20, 2018 Category: Drugs & Pharmacology Authors: Xu Y, Shan Y, Cong H, Shen Y, Yu B Tags: Curr Pharm Des Source Type: research

Antimicrobial, anticancer drug carrying properties of biopolymers-based nanocomposites-A mini review.
Abstract Biopolymers are ubiquitous in biomedical and healthcare application. Its nanocomposites have gained the more attention as antimicrobials, drug carrier, sensors, disease diagnosis, tissue engineering, wound healing and cancer therapy. These biopolymer composites are efficient in holding, protect and releasing the bioactive drugs such as pharmaceutics, nutraceuticals, enzymes and probiotics. Several studies are revealed that polymer based drug delivery system in cancer therapy and microbial treatments so on. However, this mini review emphasized the source, extraction, and characterizations of the biopolymer...
Source: Current Pharmaceutical Design - November 20, 2018 Category: Drugs & Pharmacology Authors: Saravanakumar K, Ali DM, Kathiresan K, Wang MH Tags: Curr Pharm Des Source Type: research

Biological Activities and Pharmacological Applications of Cyclodextrins Complexed with Essential Oils and Their Volatile Components: a Systematic Review.
CONCLUSION: This review of selected studies showed that the use of CDs promotes greater solubility, bioavailability and efficacy of EOs and their VCs indicating an interesting alternative for the biotechnological development of new therapeutic formulations. PMID: 30457047 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 19, 2018 Category: Drugs & Pharmacology Authors: Oliveira-Filho RD, E Silva ARA, de Azevedo Moreira R, Nogueira NAP Tags: Curr Pharm Des Source Type: research

Synaptic Plasticity in PTSD and Associated Comorbidities: The Function and Mechanism for Diagnostics and Therapy.
Abstract The studying of synaptic plasticity, the ability of synaptic connections between neurons to be weakened or strengthened and specifically long-term potentiation (LTP) and long-term depression (LTD), is one of the most active areas of research in neuroscience. The process of synaptic connections playing a crucial role in improving cognitive processes is important to the processing of information in brain. In general, the dysfunction of synaptic plasticity was involved in a wide spectrum of central nervous system (CNS) disorders, including some neurodegenerative disorders. Thus, synaptic plasticity which is ...
Source: Current Pharmaceutical Design - November 19, 2018 Category: Drugs & Pharmacology Authors: He M, Wei JX, Mao M, Zhao GY, Tang JJ, Feng S, Lu XM, Wang YT Tags: Curr Pharm Des Source Type: research

pLoc_bal-mPlant: predict subcellular localization of plant proteins by general PseAAC and balancing training dataset.
Abstract Knowledge of protein subcellular localization is vitally important for both basic research and drug development. With the avalanche of protein sequences emerging in the post-genomic age, it is highly desired to develop computational tools for timely and effectively identifying their subcellular localization based on the sequence information alone. Recently, a predictor called "pLoc-mPlant" was developed for identifying the subcellular localization of plant proteins. Its performance is overwhelmingly better than that of the other predictors for the same purpose, particularly in dealing with multi...
Source: Current Pharmaceutical Design - November 19, 2018 Category: Drugs & Pharmacology Authors: Cheng X, Xiao X, Chou KC Tags: Curr Pharm Des Source Type: research

Current Approaches to Diagnostics and Therapies of Chronic Diseases: Focus on Molecular and Cell Biology.
Abstract PMID: 30426892 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 15, 2018 Category: Drugs & Pharmacology Authors: Orekhov AN, Sukhorukov VN Tags: Curr Pharm Des Source Type: research

Coronary Microcirculation and Ischemic Heart Disease, Today.
Abstract PMID: 30426894 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 15, 2018 Category: Drugs & Pharmacology Authors: Bugiardini R Tags: Curr Pharm Des Source Type: research

Simulated protein thermal detection (SPTD) for enzyme thermostability study and an application example for pullulanase from Bacillus deramificans.
CONCLUSION: The SPTD technique presented in this paper may become a very useful tool for pharmaceutical design and protein engineering. PMID: 30421671 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 13, 2018 Category: Drugs & Pharmacology Authors: Li JX, Wang SQ, Du QS, Wei H, Li XM, Meng JZ, Wang QY, Xie NZ, Huang RB, Chou KC Tags: Curr Pharm Des Source Type: research

Nanotechnology as an emerging pathway for cancer therapy and diagnosis.
This article mainly opted advance nanotherapy methods, based on most recent studies. Result and conclusion- Nanotechnology provides new molecular contrasts agents and materials to enable earlier and more accurate initial diagnosis, as well as continual monitoring of patient while cancer treatment. This review concludes that nanotechnology as nanodrugs, nano carrier, nanoparticles in combination with radiological methods have a better future in cancer treatment. In this paper, several diagrammatic pathways presented the opted studies and proposed conclusion. PMID: 30426890 [PubMed - as supplied by publisher] (Source: C...
Source: Current Pharmaceutical Design - November 13, 2018 Category: Drugs & Pharmacology Authors: Mahmood A, Kesari KK, Fatima I, Siddiqui MH, Jamal QMS, Akhtar S, Khan MKA, Kamal MA, Arif JM Tags: Curr Pharm Des Source Type: research

Current Scenario in Structure and Ligand-Based Drug Design on Anti-Colon Cancer Drugs.
This study highlights aspects of the anticancer drug design. The structure and ligand-based drug design are discussed to investigate the molecular and quantum mechanics in anti-cancer drugs. Recent advances in anticancer agent identification driven by structural and molecular insights are presented. As a result, the recent advances in the field and the current scenario in drug designing of cancer drugs are discussed. This review provides information on how cancer drugs were formulated and identified using computational power by the drug discovery society. PMID: 30426891 [PubMed - as supplied by publisher] (Source: Cur...
Source: Current Pharmaceutical Design - November 13, 2018 Category: Drugs & Pharmacology Authors: Loganathan L, Muthusamy K Tags: Curr Pharm Des Source Type: research

Machine Learning Methods in Precision Medicine Targeting Epigenetics Diseases.
CONCLUSION: In order to make full use of machine learning algorithms, one should get familiar with the pros and cons of them, which will benefit from big data by choosing the most suitable method(s). PMID: 30421670 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Fan S, Chen Y, Luo C, Meng F Tags: Curr Pharm Des Source Type: research

Advances in antidiabetic drugs targeting Insulin Secretion.
This article will introduce the advancements of targets and drugs to promote insulin secretion. PMID: 30417774 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Ding Y, Li Y, Chen Q, Niu B Tags: Curr Pharm Des Source Type: research

Alternative routes of administration of the neuroprotective pituitary adenylate cyclase activating polypeptide.
Abstract Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with diverse actions, including strong neurotrophic and neuroprotective effects. The aim of our present review is to provide a summary of the different approaches how in vivo neuroprotective effects can be achieved, emphasizing the potential translational values for future therapeutic applications. In the central nervous system, PACAP has been shown to have in vivo protective effects in models of cerebral ischemia, Parkinson's and Alzheimer's disease, Huntington chorea, traumatic brain and spinal cord injury and different retinal...
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Reglodi D, Atlasz T, Jungling A, Szabo E, Kovari P, Manavalan S, Tamas A Tags: Curr Pharm Des Source Type: research

Brain Peptides for the Treatment of Neuropsychiatric Disorders.
Abstract The realization of the importance of growth factors in adult CNS led to several studies investigating their roles in neuropsychiatric disorders. Based on the observations that chronic stress decreases brain-derived neurotrophic factor (BDNF) and antidepressant treatments reverse BDNF to normal levels, "neurotrophic hypothesis of depression" was proposed. Subsequent studies found that several other growth factors, including fibroblast growth factor (FGF), vascular endothelial growth factor, nerve growth factor were also decreased by chronic stress. Growth factors promote stem cell survival, angio...
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Karatas H, Yemisci M, Eren-Kocak E, Dalkara T Tags: Curr Pharm Des Source Type: research

Cancer Biology Aspects of Computational Methods & Applications in Drug Discovery.
CONCLUSIONS: Our findings indicate that only a few studies have been carried out regarding this area of research. Hence, it is recommended that further research should be conducted on the computational methods for identifying candidate drugs cancers for colon cancer, prostate cancer, and other types of cancer. PMID: 30417777 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Chien ST, Kumar A, Pandey S, Yen CK, Wang SY, Wen ZH, Kaushik AC, Shiue YL, Pan CT Tags: Curr Pharm Des Source Type: research

Convolutional neural networks for ATC classification.
CONCLUSION: Extensive experiments demonstrate that the new predictor, based on CNN, outperforms other existing predictors in the literature in almost all the five metrics used to examine the performance for multi-label systems, particularly in the "absolute true" rate and the "absolute false" rate, the two most significant indexes. Matlab code will be available at https://github.com/LorisNanni. PMID: 30417778 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Lumini A, Nanni L Tags: Curr Pharm Des Source Type: research

NAP protects against Tau hyperphosphorylation through GSK3.
CONCLUSION: These results together with previous findings strongly corroborated Tau's involvement in NAP/ADNP cellular activity. PMID: 30417779 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Ivashko-Pachima Y, Gozes I Tags: Curr Pharm Des Source Type: research

Neuroprotection with the Endozepine octadecaneuropeptide, ODN.
Abstract The term endozepines designates a family of astroglia-secreted proteins including the diazepam-binding inhibitor (DBI) and its processing products, which have been originally isolated and characterized as endogenous ligands of benzodiazepine receptors. It is now clearly established that the octadecaneuropeptide ODN (DBI33-50), acting through the central-type benzodiazepine receptor or a metabotropic receptor, exerts important functions such as proconflict behavior, induction of anxiety, inhibition of pentobarbital-provoked sleep, decrease of water consumption and reduction of food intake. To mediate its e...
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Olfa MK, Yosra H, Ikram G, Seyma B, Hadhemi K, Jerome L, Helene C, Hubert V, Mohamed A, David V, Marie-Christine T Tags: Curr Pharm Des Source Type: research

Small molecules as PD-1/PD-L1 pathway modulators for cancer immunotherapy.
Abstract Blockade of PD-1/PD-L1 interaction using PD-1/PD-L1 inhibitors have demonstrated unprecedented clinical efficacy in various cancer types. Current PD-1/PD-L1 inhibitors approved by FDA are exclusively dominated by therapeutic antibodies. However, therapeutic antibodies also exhibit several disadvantages such as low tumor tissues penetration, difficult across physiological barriers, lacking oral bioavailability, immunogenicity, long half-life time and strong target occupancy, high manufacturing costs, inaccessible to intracellular targets. Modulation of PD-1/PD-L1 pathway using small molecules may be an alt...
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Jiao P, Geng Q, Jin P, Su G, Teng H, Dong J, Yan B Tags: Curr Pharm Des Source Type: research

The effects of coenzyme Q10 supplementation on metabolic profiles of patients with chronic kidney disease: A systematic review and meta-analysis of randomized controlled trials.
CONCLUSIONS: Overall, the current meta-analysis demonstrated that CoQ10 supplementation significantly improved metabolic profile in patients with CKD by reducing total-cholesterol, LDL-cholesterol, MDA and creatinine levels, yet it did not affect fasting glucose, insulin, HOMA-IR, and CRP concentrations. PMID: 30417782 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 11, 2018 Category: Drugs & Pharmacology Authors: Bakhshayeshkaram M, Lankarani KB, Mirhosseini N, Tabrizi R, Akbari M, Dabbaghmanesh MH, Asemi Z Tags: Curr Pharm Des Source Type: research

Analytical Comparison of the Originator Granulocyte-colony Stimulating Factor Filgrastim and its Biosimilars.
Abstract BACKGROUND: Filgrastim, a recombinant human granulocyte colony-stimulating factor (rhG-CSF) produced in Escherichia coli, is indicated for treatment of neutropenia-related conditions in cancer patients. It has been marketed as Neupogen since 1991. In 2006, biosimilar rhG-CSF products have been approved in the European Union (EU). OBJECTIVE: The aim of this study was to compare quality attributes of the originator filgrastim with its three biosimilars which came from the EU market in 2014 to verify whether their similarity is maintained since their market approval. METHODS: Spectrophotometric ana...
Source: Current Pharmaceutical Design - November 9, 2018 Category: Drugs & Pharmacology Authors: Orlik G, Khan MA, Grieb P Tags: Curr Pharm Des Source Type: research

Emerging trends in Advanced Nanomaterials based electrochemical genosensors.
Abstract Advanced nanomaterials indubitably represent one of the most propitious classes of new materials due to their intriguing optical, electronic and redox properties. The incredible progress achieved in this research area has been propelled by the development of novel synthetic procedures owing to the emergence of nanotechnology and by the wide range of applications. These nanostructured materials possess high surface area, biocompatibility, nontoxicity and charge-sensitive conductance which have led to the development of simple, rapid, highly sensitive, inexpensive and portable electrochemical genosensors. T...
Source: Current Pharmaceutical Design - November 9, 2018 Category: Drugs & Pharmacology Authors: Kaushik M, Khurana S, Mehra K, Yadav N, Mishra S, Kukreti S Tags: Curr Pharm Des Source Type: research

Polyphenols: plant sources and food industry applications.
CONCLUSIONS: However, careful monitoring of production is needed in order to maximize the (poly)phenol content of plant foods. PMID: 30398104 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Marranzano M, Rosa R, Malaguarnera M, Palmeri R, Tessitori M, Barbera AC Tags: Curr Pharm Des Source Type: research

Cancer Immunomics in the Age of Information: Role in Diagnostics and Beyond.
Abstract Cancer genome sequencing is useful for diagnosis and personalized treatment. Analysis of the sequencing data involves integration of computation, statistics and system biology methods. The amalgam of such methods which help study interaction of cancer cells with immune system, harnessing immune system for cancer therapy or its prevention through vaccines has led to the foundation of cancer immunomics. It is, therefore, a combinatorial science which merges diverse techniques from genomics and proteomics for diagnosis and drug design/treatment. There has been a gradual increase in establishment of cancer im...
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Basharat Z, Yasmin A, Masood N Tags: Curr Pharm Des Source Type: research

Cancer Immunoinformatics: A Promising Era in the Development of Peptide Vaccines for Human Papillomavirus induced Cervical cancer.
Abstract Cancer immunoinformatics have new directions towards in vaccine design from predicted potential epitope candidates, able to stimulate a correct cellular or humoral immune responses have been reported. It employed to accomplish an advanced vaccine design through Reverse vaccinology by replacing the whole organisms. In this review, computational tools play an essential role in evaluating multiple proteomes to identify and select the potential targeted epitopes or combinations of distinct epitopes candidates may afford a rationale design competent towards obtaining suitable cytotoxic T lymphocytes (T cell) o...
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Kaliamurthi S, Selvaraj G, Junaid M, Khan A, Gu K, Wei DQ Tags: Curr Pharm Des Source Type: research

A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine.
Abstract A complex framework of interacting partners including genetic, proteomic, and metabolic networks that cooperate to mediate specific functional phenotypes drives human biological processes. Recent technological and analytical advances in "omic" sciences allow the identification and elucidation of reprogramming biological functions in response to perturbations in cells and tissues. To understand such a complex system, biological networks are generated to reduce the complexity into relatively simple models, and the integration of these molecular networks from different perspectives is implemented f...
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Turanli B, Karagoz K, Gulfidan G, Sinha R, Mardinoglu A, Arga KY Tags: Curr Pharm Des Source Type: research

The Landscape of Protein Tyrosine Phosphatase (Shp2) and Cancer.
Conclusion: The current study was designed to focus on the allosteric regulation (autoinhibition) of the of Shp2 protein. Subsequently, it will cover the last 10-year recap of Shp2 protein, their role in cancer, and regulation in numerous ways (allosteric regulation). PMID: 30398108 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Rehman AU, Rehman MU, Tahir KM, Saud S, Liu H, Song D, Sultana P, Wadood A, Chen HF Tags: Curr Pharm Des Source Type: research

Computational and experimental binding mechanism ofDNA- drug interactions.
This article is attempts to outline those interactions of drug-DNA with both experimental and computational advances, including ultraviolet (UV)-visible spectroscopy, fluorescent spectroscopy, circular dichroism, Nuclear magnetic resonance (NMR), molecular docking & dynamics and quantum mechanical applications. PMID: 30398109 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Selvaraj C, Singh SK Tags: Curr Pharm Des Source Type: research

Detecting personalized determinates during drug treatment from omics big data.
CONCLUSIONS: Totally, detecting personalized determinates during drug treatment from omics big data will bring the precision medicine or personalized medicine from concept to application. More and more inspiring bio-technologies, data resources, and analytic approaches will benefit All of US in the near future. PMID: 30398110 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Wang L, Yu X, Zhang C, Zeng T Tags: Curr Pharm Des Source Type: research

Prospecting and Structural insight into the binding of Novel Plant-Derived Molecules of Leea indica as Inhibitors of BACE-1.
This study therefore unveiled the potent BACE1 inhibitor from a manually curated dataset of Leea indica molecules, which may provide a dimension of designing novel BACE1 inhibitors for AD therapy. PMID: 30398111 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Hosen SMZ, Rubayed M, Dash R, Junaid M, Mitra S, Alam MS, Dey R Tags: Curr Pharm Des Source Type: research

Regulation of feeding behavior and energy metabolism by galanin-like peptide (GALP): a novel strategy to conquer fight against obesity.
Abstract Galanin-like peptide (GALP) is composed of 60 amino acid residues and its sequence is highly homologous across species. GALP is produced in the hypothalamic arcuate nucleus and has diverse physiological effects such as the regulation of feeding, energy metabolism, and reproductive behavior. GALP-containing neurons express leptin receptors and these neurons form networks in the hypothalamus that contain various peptides that regulate feeding behavior. Recent studies have revealed that GALP has a central anti-obesity action in addition to its role in food intake regulation. Furthermore, we have found that t...
Source: Current Pharmaceutical Design - November 5, 2018 Category: Drugs & Pharmacology Authors: Takenoya F, Hirako S, Wada N, Nonaka N, Hirabayashi T, Kageyama H, Shioda S Tags: Curr Pharm Des Source Type: research

Computational Advances in the Label-free Quantification of Cancer Proteomics Data.
CONCLUSION: There is a dramatic increase of LFQ approaches in recent year, which significantly enhance the diversity of the possible quantification strategies for studying cancer proteomics. PMID: 30387388 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 2, 2018 Category: Drugs & Pharmacology Authors: Tang J, Zhang Y, Fu J, Wang Y, Li Y, Yang Q, Yao L, Xue W, Zhu F Tags: Curr Pharm Des Source Type: research

Advances in theoretical studies on the design of single boron atom compounds.
CONCLUSIONS: Although the strategies employed in many of the studies presented here should serve in the development of selective SBACs, it is clear that the development of the precise force field parameters, which include not only the individual atom types but also the entire molecules, is still lacking, yet it is a necessary requirement for the design of new SBACS, as well as gaining insight into their molecular recognition. PMID: 30387389 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 2, 2018 Category: Drugs & Pharmacology Authors: Bello M Tags: Curr Pharm Des Source Type: research

"Novel Topical Nanocarriers For Treatment Of Psoriasis: An Overview".
CONCLUSION: Present review is an attempt to contemplate on psoriasis as far as Improved comprehension of the dermal delivery perspectives and at present accessible treatment alternatives, significant preventions in psoriasis treatment, late advancements in the conveyance of different antipsoriatic drugs through novel colloidal drug transporters. PMID: 30387390 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 2, 2018 Category: Drugs & Pharmacology Authors: Dadwal A, Mishra N, Narang RK Tags: Curr Pharm Des Source Type: research

Emerging Clinical Applications of Heme Oxygenase.
Abstract PMID: 30378488 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 1, 2018 Category: Drugs & Pharmacology Authors: Haines D, Tosaki A Tags: Curr Pharm Des Source Type: research

Crystallization for Pharmaceutical and Food Science.
Abstract PMID: 30378491 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - November 1, 2018 Category: Drugs & Pharmacology Authors: Hao H, Yin Q, Zhong J, Wang X Tags: Curr Pharm Des Source Type: research