The Effect of PDE5 Inhibitors on the Male Reproductive Tract.
is C, Takenaka A Abstract The therapeutic range of cyclic nucleotide phosphodiesterase 5 inhibitors (PDE5) inhibitors is getting wider in the last years. This review study focuses on the potential employment of PDE5 inhibitors as an adjunct tool for the therapeutic management of male infertility. The literature tends to suggest a beneficial effect of PDE5 inhibitors on Leydig and Sertoli cells secretory function. It also appears that PDE5 inhibitors play a role in the regulation of the contractility of the testicular tunica albuginea and the epididymis. Moreover scientific data suggest that PDE5 inhibitors enhance...
Source: Current Pharmaceutical Design - February 26, 2020 Category: Drugs & Pharmacology Authors: Sofikitis N, Kaltsas A, Dimitriadis F, Rassweiler J, Grivas N, Zachariou A, Kaponis A, Tsounapi P, Paterakis N, Karagiannis A, Skouros S, Giannakis I, Champilomatis I, Paschopoulos M, Daphnis D, Giakoumakis I, Gabales MR, M Chua JB, Lantin Iii PL, Mamoula Tags: Curr Pharm Des Source Type: research

LncRNAs a new target for post-stroke recovery.
Abstract LncRNAs (long non-coding RNAs) are endogenous molecules and involved in complicated biological processes. Increasing evidence has shown that lncRNAs play a vital role in the post-stroke pathophysiology.Furthermore, several lncRNAs were reported to mediate ischemia cascade processes include apoptosis, excitotoxicity, oxidative stress, angiogensis, neuroinfla- mmation, microglial cell which can cause neuron injury and influence neuron recovery after ischemic stroke. In our study, we first summarize current development about lncRNAs and post-stroke, focus on the regulatory roles of lncRNAs on pathophysiology...
Source: Current Pharmaceutical Design - February 25, 2020 Category: Drugs & Pharmacology Authors: Zhao J, Jun Y, Liu X, Zhu R Tags: Curr Pharm Des Source Type: research

Multiple risk factors: A challenge in the management of Autism.
Abstract Autism Spectrum Disorder (ASD) is an emerging health problem involving 1 out of every 68 children. The incidence rate of autism has increased 3 folds during last 3 decades. Due to the illusive picture of aetiology a considerable number of autistic children fail to receive proper behavioural and medicational treatment. The present study provides a cumulative account of autism risk factors. Several factors including the gene expression and gene mutations, environmental pollution, metal ion accumulation, exposure to pesticides, immune deficiencies, viral infections, mother's age, health, mental status, mothe...
Source: Current Pharmaceutical Design - February 25, 2020 Category: Drugs & Pharmacology Authors: Nadeem MS, Al-Abbasi FA, Kazmi I, Murtaza BN, Zamzami MA, Kamal MA, Arif A, Afzal M, Anwar F Tags: Curr Pharm Des Source Type: research

Neuropsychological Disorders and Their Nanocarriers.
Abstract Neuropsychological disorders are growing rapidly worldwide recently amongst the people of diverse background irrespective of age, gender and geographical region. such disorders not only disturb the normal life and functionality of an individual but also impacts the social relationships of the patient and of the people associated with them, and if not treated in time it may also result into mortality in severe conditions. Various antipsychotic drugs have been developed but their use is often limited by issues related to effective drug delivery at the site of action i.e. brain, mainly because of the blood b...
Source: Current Pharmaceutical Design - February 23, 2020 Category: Drugs & Pharmacology Authors: Sharma S, Dang S Tags: Curr Pharm Des Source Type: research

Bacterial Resistance: antibiotics of last generation used in clinical practice and the arise of natural products as new therapeutic alternatives.
ICFR Abstract Bacterial resistance to the therapeutical drugs has been a serious issue over the last decades. In fact, the quick development of resistance mechanisms by the microorganisms has been fatal for millions of people around the world, turning into a public health issue. The major cause for the resistance mechanisms is the overuse of antimicrobials. European countries try to implement mechanisms to overcome antimicrobial resistance in the community through the rational use of antimicrobials. The scientific community has been exhaustively dedicated to the discovering of new, safer and efficient drugs, being...
Source: Current Pharmaceutical Design - February 23, 2020 Category: Drugs & Pharmacology Authors: Corrêa RCG, Heleno SA, Alves MJ, Ferreira ICFR Tags: Curr Pharm Des Source Type: research

Role of ATP-Binding Cassette Transporter Proteins in CNS tumors: Resistance-based perspectives and clinical updates.
Abstract Despite gigantic advances in medical research and development, chemotherapeutic resistance remains a major challenge for CNS tumors. The failure of complete eradication of CNS tumors has been correlated with the existence of several factors including over expression of transporter proteins. To date, 49 ABC-transporter proteins (ABC-TPs) are reported in humans, and the evidence of their strong association with chemotherapeutics' influx, dissemination, and efflux in CNS tumors, is growing. Research studies in CNS tumor are implicating ABC-TPs as diagnostic, prognostic and therapeutic biomarkers that may be ...
Source: Current Pharmaceutical Design - February 23, 2020 Category: Drugs & Pharmacology Authors: Asif M, Usman M, Ayub S, Farhat S, Huma Z, Ahmad J, Kamal A, Hussein D, Javed A, Khan I Tags: Curr Pharm Des Source Type: research

Drug Development for Central Nervous System Diseases Using In Vitro Blood-brain Barrier Models and Drug Repositioning.
Abstract An important goal of biomedical research is to translate basic research findings into practical clinical implementation. Despite the advances in the technology used in drug discovery, the development of drugs for central nervous system diseases remains challenging. The failure rate for new drugs targeting important central nervous system diseases is high compared to most other areas of drug discovery. The main reason of the failure is the poor penetration efficacy across the blood-brain barrier. The blood-brain barrier represents the bottleneck in central nervous system drug development and is the most im...
Source: Current Pharmaceutical Design - February 23, 2020 Category: Drugs & Pharmacology Authors: Morofuji Y, Nakagawa S Tags: Curr Pharm Des Source Type: research

Trends In Nanotechnology For In Vivo Cancer Diagnosis: Products And Patents.
CONCLUSION: Although few systems are found in the market and patented, nanotechnology appears as a promising field for the development of new nanosystems in order to optimize and accelerate the cancer diagnosis. PMID: 32072890 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 18, 2020 Category: Drugs & Pharmacology Authors: do Nascimento T, Tavares M, de Souza de Bustamante Monteiro MS, Santos-Oliveira R, Todeschini AR, de Souza VT, Júnior ER Tags: Curr Pharm Des Source Type: research

Precision Medicine Approach in Prostate Cancer.
Abstract Prostate cancer is the most prevalent form of cancer and the second cause of death in men worldwide. Various diagnostic and treatment procedures are available for this type of malignancy, but High-risk or locally advanced prostate cancers showed the potential to develop to lethal phase that can be causing dead. Therefore, new approaches are needed to prolong patient survival and provide a better quality of life. Precision medicine is a novel emerging field that has an essential role in identifying new sub-classifications of disease and guiding treatment based on individual multi-omics data. Multi-omics ap...
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Assadi M, Jokar N, Ghasemi M, Nabipour I, Gholamrezanezhad A, Ahmadzadehfar H Tags: Curr Pharm Des Source Type: research

Survival of beneficial vaginal lactobacilli (BVLB) to different gastrointestinal tract conditions.
CONCLUSION: The behavior of BVL in the conditions assayed is not related to specific strain or metabolic group, because the resistance is strain-specific. The results highlight the importance of the screening performed in a way to select the most adequate strains to be included in oral designed formula for the restoration of vaginal tract microbiome. PMID: 32067602 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Marchesi A, Silva J, Wiese B, Nader-Macías MEF Tags: Curr Pharm Des Source Type: research

Issues with cancer spheroid models in therapeutic drug screening.
h E Abstract In vitro screening for anti-cancer agents currently uses mainly cell lines in 2D culture. It is generally assumed that 3D culture, namely spheroids, represent physiologically more relevant models for tumors. Unfortunately, drug testing in spheroids is not as easy and reproducible as in 2D culture because there are factors that limit the universal use of spheroids as screening platforms. Technical problems in the generation of uniform spheroids, cell/tumor-specific differences in the ability to form spheroids, and more complex readout parameters are main reasons for differences between spheroid data. T...
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Fröhlich E Tags: Curr Pharm Des Source Type: research

The association between metformin and head and neck cancer survival: a systematic review and meta-analysis of cohort studies.
CONCLUSION: In this meta-analysis of 7 retrospective cohort studies, there was not a statistically significant association between use of metformin and better survival for head and neck cancer. However, the analysis may have been underpowered. More studies of prospective designs with larger sample sizes are needed to investigate the effect of metformin on the survival for head and neck cancer. PMID: 32067604 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Wang Y, Fu T, Liu Y, Yang G, Yu C, Zhang ZJ Tags: Curr Pharm Des Source Type: research

Selective vascular endothelial growth factor receptor inhibitors provide limited benefits for metastatic colorectal cancer: a meta-analysis.
CONCLUSION: Compared with placebo or cetuximab, selective VEGFR inhibitors alone or combined with cetuximab seemed to be more efficacious for mCRC respectively; however, the effects were not better than FOLFOX4 alone or when combined with bevacizumab for mCRC. Additionally, selective VEGFR inhibitors were not as safe as placebo or FOLFOX4 alone or in combination with bevacizumab in mCRC. PMID: 32067605 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Fan Q, Lv H, Xu Y, Dong Y, Xiang Z, Wang J Tags: Curr Pharm Des Source Type: research

Dietary amino acids and immunonutrition supplementation in cancer-induced skeletal muscle mass depletion: A mini review.
Abstract Cancer patients display systemic inflammation which leads to an increase in protein catabolism, thus promoting the release of free amino acids to further support metabolism and remodelling of muscle proteins. Inflammation associated with tumor growth leads to malnutrition, a factor that increases the risk of developing cachexia. With cancer-induced cachexia, nutritional interventions have gained traction as a preventative method to manage this condition. Currently, cancer consensus recommendations suggest a protein intake above 1.0 g/kg.day-1 up to 2.0 g/k.day-1 for cancer patients although an ideal amoun...
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Soares JDP, Howell SL, Teixeira FJ, Pimentel GD Tags: Curr Pharm Des Source Type: research

Lipid nanoparticles as carriers for the treatment of neurodegeneration associated with Alzheimer's disease and glaucoma: present and future challenges.
D, Souto EB Abstract Glaucoma constitutes the second cause of blindness worldwide and it is considered a neurodegenerative. In this sense, Alzheimer's disease, which is the most common type of dementia, causes also neurodegeneration. The association between both diseases remains unknown although it has been hypothesised that a possible connection between both diseases might exist. And it will be analysed throughout the review. In this sense, nanoparticulate systems and specially, lipid nanoparticles could be the key for an effective neuroprotection. Lipid nanoparticles are the most recent type of drug nanoparticul...
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Sánchez López E, Lopez Machado AL, Vidal LB, Pizarro RG, Silva AD, Souto EB Tags: Curr Pharm Des Source Type: research

Cerebrovascular Changes and Neurodegeneration Related to Hyperlipidemia: Characteristics of the Human ApoB-100 Transgenic Mice.
cute;ntha M Abstract Serum lipid levels are closely related to the structure and function of blood vessels. Chronic hyperlipidemia may lead to damage in both the cardio- and the cerebrovascular systems. Vascular dysfunctions, including impairments of the blood-brain barrier, are known to be associated with neurodegenerative diseases. A growing number of evidence suggests that cardiovascular risk factors, such as hyperlipidemia, may increase the likelihood of developing dementia. Due to differences in lipoprotein metabolism, wild-type mice are protected against diet-induced hypercholesterolemia, and their serum lip...
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Tóth ME, Dukay B, Hoyk Z, Sántha M Tags: Curr Pharm Des Source Type: research

Bench-to-Bedside Theranostics in Nuclear Medicine.
Abstract The optimum selection of the appropriate radiolabelled probe for the right target and the right patient is the foundation of theranostics in personalised medicine. In nuclear medicine, this process is realised through the appropriate choice of radiopharmaceuticals based on molecular biomarkers in concert with molecular imaging. Theranostics is developing a strategy that can be used to implement accepted tools for individual molecular targeting, including diagnostics, and advances in genomic molecular knowledge has led to identifying theranostics biomaterials that have the potency to diagnose and treat mal...
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Jokar N, Assadi M, Yordanova A, Ahmadzadehfar H Tags: Curr Pharm Des Source Type: research

Activity of Metal-Azole Complexes against Biofilms of Candida albicans and Candida glabrata.
CONCLUSION: In conclusion, metal-azole complexes used in this work show promising anti-biofilm activity and further clinical studies should confirm its potential for the treatment of Candida-associated onychomycosis. PMID: 32065088 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 17, 2020 Category: Drugs & Pharmacology Authors: Pereira LD, Vila T, Borba-Santos LP, de Souza W, Navarro M, Rozental S Tags: Curr Pharm Des Source Type: research

Current Therapeutic Strategies and Perspectives for Neuroprotection in Parkinson's Disease.
Abstract Parkinson's disease is a progressive neurodegenerative disorder of dopaminergic striatal neurons in basal ganglia. Treatment of Parkinson's disease (PD) through dopamine replacement strategies may provide improvement in early stages and this treatment response is related to dopaminergic neuronal mass which decreases in advanced stages. This treatment failure was revealed by many studies and levodopa treatment becomes ineffective or toxic in chronic stages of PD. Early diagnosis and neuroprotective agents may be a suitable approach for treatment of PD. The essentials required for early diagnosis are biomar...
Source: Current Pharmaceutical Design - February 16, 2020 Category: Drugs & Pharmacology Authors: Ghanta MK, Elango P, Bhaskar L V K S Tags: Curr Pharm Des Source Type: research

Docking related survey on the Heterocyclic compounds based Glucosamine-6-Phosphate Synthase inhibitors and their antimicrobial potential.
Abstract The synthetic heterocyclic compounds have their importance due to their wide applications in various field of science. The heterocyclic compounds have been reported for their anticancer, antitubercular, insecticides, analeptics, analgesic, anti-bacterial, anti-viral, anti-fungal, and weedicidal activity. Researchers have tried various newer targets for search of better antimicrobials acting via novel mechanisms. Glucosamine-6-Phosphate synthase is an enzyme present in microbial cells. The inactivation of G-6-P synthase may serve as a novel approach to find better antimicrobial. The increasing demands deve...
Source: Current Pharmaceutical Design - February 16, 2020 Category: Drugs & Pharmacology Authors: Lather A, Sharma S, Khatkar S, Khatkar A Tags: Curr Pharm Des Source Type: research

Ameliorative effects and cellular aspects of phytoconstituents in atherosclerosis.
Abstract Atherosclerosis is a cardiovascular disease that involves vessels through the development of fatty streaks and plaques. Plant-based compounds can help treat or prevent atherosclerosis by affecting various factors that are involved in the disease. The present review discusses our current knowledge of the major cellular and molecular mechanisms of phytotherapeutics for the treatment of atherosclerosis. Numerous studies have evaluated the antiatherosclerotic activity of phytoconstituents to provide preliminary evidence of efficacy, but only a few studies have delineated the underlying molecular mechanisms. P...
Source: Current Pharmaceutical Design - February 14, 2020 Category: Drugs & Pharmacology Authors: Alamgeer, Asif H, Ahmad Sandhu MZ, Aziz M, Irfan HM, Tafarelo Moreno KG, Junior AG Tags: Curr Pharm Des Source Type: research

Surface-Engineered Cancer Nanomedicine: Rational Design And Recent Progress.
Abstract Cancer is highly heterogeneous in nature and characterized by abnormal cells grow uncontrollably. It is responsible for second leading cause of death in the world. Nanotechnology is explored profoundly for site-specific delivery of cancer chemotherapeutics as well as overcome multidrug-resistance (MDR) challenges in cancer. The progress in design of various smart biocompatible materials (such as polymers, lipids and inorganic materials) has now been revolutionized the area of cancer research for rational design of nanomedicine by surface engineering with targeting ligands. The small tunable size and surfa...
Source: Current Pharmaceutical Design - February 13, 2020 Category: Drugs & Pharmacology Authors: Ahmad J, Ameeduzzafar, Ahmad MZ, Akhter MH Tags: Curr Pharm Des Source Type: research

Manipulation of pharmaceutical polymorphic transformation process using excipients.
CONCLUSION: Using appropriate excipients plays a role in manipulating polymorphic transformation process of corresponding APIs, with promising application of guaranteeing the stability and effectiveness of drug dosage forms. PMID: 32053064 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 13, 2020 Category: Drugs & Pharmacology Authors: Tian B, Ding Z, Zong S, Yang J, Wang N, Wang T, Huang X, Hao H Tags: Curr Pharm Des Source Type: research

Molecular mechanisms and therapeutic targets of inflammatory-related Cardiovascular diseases: from molecular mechanisms to therapeutic targets.
Abstract Inflammation is a pathogenic response to multiple factors, that cause over activation of different molecules and pro-inflammatory cellular lines. Different behavioral factors and risk factors might enhance the inflammatory stress, and this might cause cardiovascular disease (CVD). CVD is the world's leading cause of morbidity and mortality, and it is represented by hypertension, coronary heart disease, cerebrovascular disease, peripheral vascular disease, heart failure, rheumatic heart disease, congenital heart disease and cardiomyopathies. In this context, inflammation is both a cause and an aggravating ...
Source: Current Pharmaceutical Design - February 13, 2020 Category: Drugs & Pharmacology Authors: Sardu C, Paolisso G, Marfella R Tags: Curr Pharm Des Source Type: research

Common neural mechanisms of palatable food intake and drug abuse: knowledge obtained with animal models.
cute;guez-Arias M Abstract Eating is necessary for survival, but it is also one of the great pleasures enjoyed by human beings. Research to date shows that palatable food can be rewarding in a similar way to drugs of abuse, indicating a considerable comorbidity between eating disorders and substance-use disorders. Analysis of the common characteristics of both types of disorder has led to a new wave of studies proposing a Gateway Theory of food as a vulnerability factor that modulates the development of drug addiction. The homeostatic and hedonic mechanisms of feeding overlap with some of the mechanisms implicated...
Source: Current Pharmaceutical Design - February 13, 2020 Category: Drugs & Pharmacology Authors: Blanco-Gandía MC, Miñarro J, Rodríguez-Arias M Tags: Curr Pharm Des Source Type: research

Formulation strategies of nano lipid carrier for effective brain targeting of anti-AD drugs.
Abstract NLC is a next-generation lipid nanocarrier which holds many advantages over other colloidal lipid carrier system like higher drug loading, better and controlled release and enhanced stability. Owing to the unique structural composition, i.e. crystallized solid and liquid lipid blend it offers excellent biocompatibility and higher permeation across physiological membranes like BBB. Moreover, the surface of NLC can be easily modified with target-specific ligands, proteins, peptides, etc. which makes it a potential candidate for brain targeting of CNS acting drugs. NLC has found various applications in treat...
Source: Current Pharmaceutical Design - February 12, 2020 Category: Drugs & Pharmacology Authors: Alexander A, Agrawal M, Saraf S, Saraf S, Ajazuddin, Chougule MB Tags: Curr Pharm Des Source Type: research

Inhibition of Bacterial Biofilm Formation by Phytotherapeutics with Focus on Overcoming Antimicrobial Resistance.
te; T Abstract Bacteria within biofilms are more resistant to antibiotics and chemical agents than planktonic bacteria in suspension. Treatment of biofilm-associated infections inevitably involves high dosages and prolonged courses of antimicrobial agents; therefore, there is a potential risk of the development of antimicrobial resistance (AMR). Due to the high prevalence of AMR and its association with biofilm formation, investigation of more effective anti-biofilm agents is required. From ancient times, herbs and spices have been used to preserve foods, and their antimicrobial, anti-biofilm and anti-quorum sensi...
Source: Current Pharmaceutical Design - February 12, 2020 Category: Drugs & Pharmacology Authors: Janga YS, Mosolygó T Tags: Curr Pharm Des Source Type: research

Administration of pharmaceutical agents prior to testicular sperm extraction procedures: A meaningful or meaningless approach?
CONCLUSION: Based on the published studies, in the presence of normal range of peripheral serum total testosterone level, no medical treatment is advised, and TESE procedures should be performed directly in men with NOA. Further well-designed and randomized, placebo controlled trials are needed to support the potential benefit of pretreatment prior to TESE procedures. PMID: 32053067 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 12, 2020 Category: Drugs & Pharmacology Authors: Çayan S, Yaman O Tags: Curr Pharm Des Source Type: research

A novel sentinel lymph node approach in oral squamous cell carcinoma.
CONCLUSION: This paper presents a novel protocol for identification of sentinel node in the head and neck region. The protocol additionally enables the use of flow cytometry analysis of resected lymph nodes. PMID: 32053068 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 12, 2020 Category: Drugs & Pharmacology Authors: Kågedal Å, Margolin G, Held C, da Silva PFN, Piersiala K, Munck-Wikland E, Jacobsson H, Häyry V, Cardell LO Tags: Curr Pharm Des Source Type: research

DPepH3, an Improved Peptide Shuttle for Receptor-independent Transport across the Blood-Brain Barrier.
Abstract The use of peptides as drug carriers across the blood-brain barrier (BBB) has increased significantly during the last decades. PepH3, a seven residue sequence (AGILKRW) derived from the α-helical domain of the dengue virus type-2 capsid protein, translocates across the BBB with very low toxicity. Somehow predictably from its size and sequence, PepH3 is degraded in serum relatively fast. Among strategies to increase peptide half-life (t1/2), use of the enantiomer (wholly made of D-amino acid residues) can be quite successful if the peptide interacts with a target in non-stereospecific fashion. Here w...
Source: Current Pharmaceutical Design - February 12, 2020 Category: Drugs & Pharmacology Authors: Cavaco MC, Garcia JV, da Silva RDM, Correia JDG, Castanho MARB, Andreu Martinez D, Neves VLS Tags: Curr Pharm Des Source Type: research

Stimulation of Leydig and Sertoli cellular secretory function by anti-oestrogens: Tamoxifen.
In this study, we performed a literature search of the OVID medline database and identified 37 studies describing the effects of tamoxifen which we then reviewed. Evidence suggests Tamoxifen effectively increases androgen levels and sperm concentrations in males with idiopathic oligozoospermia. Evidence for increased motility and pregnancy rates in these patients is less conclusive. Further randomised control trials are needed to elucidate the safety of Tamoxifen combination therapies and their efficacy in improving pregnancy rates. PMID: 32053070 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 12, 2020 Category: Drugs & Pharmacology Authors: Dimakopoulou A, Foran D, Jayasena CN, Minhas S Tags: Curr Pharm Des Source Type: research

Potential therapeutic role of carnitine and acetylcarnitine in neurological disorders.
CONCLUSIONS: ALCAR emerges as a simple, economical and safe adjuvant option in order to impair the progression of most neurological disorders. PMID: 32048954 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 11, 2020 Category: Drugs & Pharmacology Authors: Maldonado C, Vázquez M, Fagiolino P Tags: Curr Pharm Des Source Type: research

Hormonal Male Contraception.
Abstract The demand for availability of efficient and safe contraceptive methods is strengthened by the predictions made by the United Nations regarding the future growth of the human population. So far, the women are not only the main victims of the unsafe procedures related to terminating unwished pregnancies but do also carry the main responsibility for family planning. There is a significant desire among the men for sharing this responsibility and a substantial proportion of the females are willing to trust their male partners in regard to use of contraception. There is, therefore, a need of developing new rev...
Source: Current Pharmaceutical Design - February 11, 2020 Category: Drugs & Pharmacology Authors: Giwercman A Tags: Curr Pharm Des Source Type: research

Universal Human Papillomavirus Vaccination And Impact In A Southern Italian Region.
Abstract HPV is still the most common sexually transmitted infection, leading to the onset of many disorders while causing an increase in direct and indirect health costs. High Risk (HR) HPV is the primary cause of invasive cervical cancer and contributes significantly to the development of anogenital and oropharyngeal cancers. The introduction of universal HPV vaccination has led to a significant reduction in vaccine-targeted HPV infections, cross-protective genotypes, precancerous lesions and anogenital warts. Despite the several limitations of HPV vaccination programs, including vaccine type specificity, differ...
Source: Current Pharmaceutical Design - February 11, 2020 Category: Drugs & Pharmacology Authors: Guido M, Bruno A, Tagliaferro L, Aprile V, Tinelli A, Fedele A, Lobreglio G, Menegazzi P, Pasanisi G, Tassi V, Forcina B, Fortunato F, Lupo LI, Zizza A Tags: Curr Pharm Des Source Type: research

Vesicular Transport Machinery in Brain Endothelial Cells: What We Know and What We Don`t.
Abstract The vesicular transport machinery regulates numerous essential functions in cells such as cell polarity, signalling pathways, and the transport of receptors and their cargoes. From a pharmaceutical perspective, vesicular transport offers avenues to facilitate the uptake of therapeutic agents into cells and across cellular barriers. In order to improve receptor-mediated transcytosis of biologics across the blood-brain barrier and into the diseased brain, a detailed understanding of intracellular transport mechanisms is essential. The vesicular transport machinery is a highly complex network and involves an...
Source: Current Pharmaceutical Design - February 11, 2020 Category: Drugs & Pharmacology Authors: Toth AE, Holst MR, Nielsen MS Tags: Curr Pharm Des Source Type: research

Pine bark phenolic extract: current uses and potential food applications.
CONCLUSION: PBPE represent an opportunity for the development of functional foods with phenolic-rich bioactive compounds. PMID: 32048960 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 11, 2020 Category: Drugs & Pharmacology Authors: Dridi W, Bordenave N Tags: Curr Pharm Des Source Type: research

Human health effects of lactose consumption as food and drug ingredient.
M, Cordoba-Diaz D Abstract Lactose is a reducing sugar consisting of galactose and glucose, linked by a β (1→4) glycosidic bond, considered as an antioxidant due to its α-hydroxycabonyl group. Lactose is widely ingested through milk and other unfermented dairy products and is considered to be one of the primary foods. On the other hand, lactose is also considered as one of the most widely used excipient for the development of pharmaceutical formulations. In this sense, lactose has been related with numerous drug-excipient or drug-food pharmacokinetic interactions. Intolerance, maldigestion and ...
Source: Current Pharmaceutical Design - February 11, 2020 Category: Drugs & Pharmacology Authors: Seoane RG, Garcia-Recio V, Garrosa M, Rojo MÁ, Jiménez P, Girbés T, Cordoba-Diaz M, Cordoba-Diaz D Tags: Curr Pharm Des Source Type: research

Caffeoylquinic acids with potential biological activity from plant in vitro cultures as alternative sources of valuable natural products.
CONCLUSION: The results indicate that the various in vitro cultures of different plant species can be profitable approach for production of CQAs. In particular an efficient production of these valuable compounds is possible by Lonicera macranthoides and Eucomia ulmoides cell suspension cultures, Leonurus sibiricus transformed roots and AtPAP1 transgenic roots, Echinacea angustifolia adventitious shoots, Rhaponticum carthamoides transformed plants, Lavandula viridis shoots, Sausera involucrata cell suspension and Cichorium intybus transformed roots. PMID: 32048962 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 11, 2020 Category: Drugs & Pharmacology Authors: Skała E, Makowczyńska J, Wieczfinska J, Kowalczyk T, Sitarek P Tags: Curr Pharm Des Source Type: research

Lipophilic Guanylhydrazone Analogues As Promising Trypanocidal Agents: An Extended SAR Study.
In this report, we extend the SAR analysis of a number of lipophilic guanylhydrazone analogues with respect to in vitro growth inhibition of Trypanosoma brucei and Trypanosoma cruzi. Sleeping sickness and Chagas disease, caused by the tropical parasites T. brucei and T. cruzi, constitute a significant socioeconomic burden in low-income countries of sub-Saharan Africa and Latin America, respectively. Drug development is under-funded. Moreover, current treatments are outdated and difficult to administer, while drug resistance is an emerging concern. The synthesis of adamantane-based compounds that have potential as antitrypa...
Source: Current Pharmaceutical Design - February 10, 2020 Category: Drugs & Pharmacology Authors: Pardali V, Giannakopoulou E, Balourdas DI, Myrianthopoulos V, Taylor MC, Šekutor M, Mlinarić-Majerski K, Kelly JM, Zoidis G Tags: Curr Pharm Des Source Type: research

An overview of structural aspects and health beneficial effects of antioxidant oligosaccharides.
CONCLUSION: A great amount of high quality evidence has been accumulating during the last decade in support to a meaningful antioxidant activity of oligosaccharides and derivatives. Ingestion of antioxidant oligosaccharides can be visualized as beneficial to human and animal health. PMID: 32039673 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 9, 2020 Category: Drugs & Pharmacology Authors: Vieira TF, Corrêa RCG, Peralta RA, de Fátima Peralta-Muniz-Moreira R, Bracht A, Peralta RM Tags: Curr Pharm Des Source Type: research

Development of a novel oral delivery vehicle for probiotics.
Abstract BACKGROUND: There is significant interest in effective oral drug delivery of therapeutic substances. For probiotics, there is a particular need for a delivery platform that protects the bacteria from destruction by the acidic stomach while enabling targeted delivery to the intestine where microbiota naturally reside. The use of probiotics and how they impact the gut microbiota is a growing field and holds promise for the treatment of a variety of gastrointestinal diseases including irritable bowel disease Crohn's disease and C. diff and other diseases, such as obesity, diabetes, Parkinson's, and Alzheimer...
Source: Current Pharmaceutical Design - February 9, 2020 Category: Drugs & Pharmacology Authors: Enck K, Banks S, Yadav H, Welker ME, Opara EC Tags: Curr Pharm Des Source Type: research

A traditional Chinese medicine YXQN reduces amyloid-induced cytotoxicity by inhibiting A β42 aggregation and fibril formation.
CONCLUSION: Based on these results, YXQN exerts a neuroprotective effect by inhibiting Aβ42 toxic aggregation, which has the potential to combat AD. PMID: 32031066 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 7, 2020 Category: Drugs & Pharmacology Authors: Wang L, Liu S, Xu J, Watanabe N, Di J, Wei W, Mayo KH, Li J, Li X Tags: Curr Pharm Des Source Type: research

Lipid-based nanosystem as intelligent carriers for versatile drug delivery applications.
LIPID-BASED NANOSYSTEM AS INTELLIGENT CARRIERS FOR VERSATILE DRUG DELIVERY APPLICATIONS. Curr Pharm Des. 2020 Feb 05;: Authors: Harshita, Barkat MA, Das SS, Pottoo FH, Beg S, Rahman Z Abstract The contemporary drug discovery research shows that the most of the drug candidates are highly potent but showing poor aqueous solubility leads a variety of challenges for formulation scientists to develop a suitable formulation to improve the systemic bioavailability of such drugs. Lipid based nanocarriers act as a major and most projecting approach overcoming the limitations which affects several physiochemica...
Source: Current Pharmaceutical Design - February 5, 2020 Category: Drugs & Pharmacology Authors: Harshita, Barkat MA, Das SS, Pottoo FH, Beg S, Rahman Z Tags: Curr Pharm Des Source Type: research

Novel Polymethoxylated Chalcones as potential compounds against KRAS-Mutant Colorectal Cancers.
CONCLUSION: Compounds 3 and 14 represent potent and selective leads for KRAS-mutant CRC cells, thus, further in vitro and in vivo studies are necessary to confirm their effect on KRAS-mutant CRCs. PMID: 32026770 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 5, 2020 Category: Drugs & Pharmacology Authors: Mahmoud A, Elkhalifa D, Alali F, Al Moustafa AE, Khalil A Tags: Curr Pharm Des Source Type: research

Hippocampal-Dependent Inhibitory Learning and Memory Processes in the Control of Eating and Drug Taking.
Abstract As manifestations of excessive and uncontrolled intake, obesity and drug addiction have generated much research aimed at identifying common neuroadaptations that could underlie both disorders. Much work has focused on changes in brain reward and motivational circuitry that can overexcite eating and drug-taking behaviors. We suggest that the regulation of both behaviors depends on balancing excitation produced by stimuli associated with food and drug rewards with the behavioral inhibition produced by physiological "satiety" and other stimuli that signal when those rewards are unavailable. Our mai...
Source: Current Pharmaceutical Design - February 5, 2020 Category: Drugs & Pharmacology Authors: Clasen MM, Riley AL, Davidson TL Tags: Curr Pharm Des Source Type: research

Behavioral and Neurobiological Consequences of Hedonic Feeding on Alcohol Drinking.
Abstract A complex interplay of peripheral and central signaling mechanisms within the body of an organism maintains energy homeostasis. In addition, energy/food intake is modified by various external factors (e.g., palatability, food availability, social and environmental triggers). Highly palatable foods can provoke maladaptive feeding behavior, which in turn disrupts normal homeostatic regulation resulting in numerous health consequences. Furthermore, neuroendocrine peptides, traditionally considered to regulate appetite and energy homeostasis, also control the intake and reinforcing properties of alcohol and d...
Source: Current Pharmaceutical Design - February 5, 2020 Category: Drugs & Pharmacology Authors: Brutman J, Davis JF, Sirohi S Tags: Curr Pharm Des Source Type: research

Heterocycle compounds with antimicrobial activity.
CONCLUSION: It should be mentioned that despite the progress in the development of new antimicrobial agents there is still room for new findings. Thus, research still continues. PMID: 32026773 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 5, 2020 Category: Drugs & Pharmacology Authors: Fesatidou M, Petrou A, Geronikaki A Tags: Curr Pharm Des Source Type: research

Modulatory Effects of Food Restriction on Brain and Behavioral Effects of Abused Drugs.
Abstract Energy homeostasis is achieved, in part, by metabolic signals that regulate the incentive motivating effects of food and its cues, thereby driving or curtailing procurement and consumption. The neural underpinnings of these regulated incentive effects have been identified as elements within the mesolimbic dopamine pathway. A separate line of research has shown that most drugs with abuse liability increase dopamine transmission in this same pathway and thereby reinforce self-administration. Consequently, one might expect shifts in energy balance and metabolic signaling to impact drug abuse risk. Basic scie...
Source: Current Pharmaceutical Design - February 4, 2020 Category: Drugs & Pharmacology Authors: Carr KD Tags: Curr Pharm Des Source Type: research

Antioxidant phytochemicals in pulses and their relation to human health: A Review.
Ruiz V, Morales P Abstract Pulses are staple foods cultivated since ancient times, which play an important role in the human diet. From a nutritional point of view, pulses are very interesting foods as they are rich in proteins, carbohydrates and dietary fiber. Dietary antioxidants are a complex mixture of hydrophilic and lipophilic compounds usually present in foods of plant origin, including pulses. In the present study, the phytochemical composition of selected pulses (common beans, fava beans, lentils, chickpeas, peas and lupins) have been reviewed in terms of their content of antioxidant compounds. The conten...
Source: Current Pharmaceutical Design - February 3, 2020 Category: Drugs & Pharmacology Authors: Ciudad-Mulero M, Matallana-González MC, Cámara M, Fernádez-Ruiz V, Morales P Tags: Curr Pharm Des Source Type: research

Bentonite clays for therapeutic purposes and biomaterial design.
CONCLUSION: Numerous publications have cited bentonite extensive applications as an alternative and complementary treatment for numerous health conditions and as detoxifying agent and for the preparation of several bionanocomposites. PMID: 32013819 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 3, 2020 Category: Drugs & Pharmacology Authors: Srasra E, Bekri-Abbes I Tags: Curr Pharm Des Source Type: research