The value of urinary cystatin C level to predict neonatal kidney injury.
Abstract BACKGROUND: The role of urinary cystatin C to early predict acute kidney injury (AKI) in children and neonates remains uncertain. The present study aimed to assess and compare the level of urinary cystatin C in neonates with and those without AKI. METHODS: This cross-sectional study was performed on 55 available neonates who were involved by AKI and admitted to neonatal department at Ali-Asghar hospital in Tehran in 2016. Ninety-seven neonates with jaundice and normal serum creatinine level were randomly selected as the control group. In both groups and on admission, the urine levels of cystatin C an...
Source: Current Pharmaceutical Design - September 17, 2018 Category: Drugs & Pharmacology Authors: Khosravi N, Zadkarami M, Chobdar F, Hoseini R, Khalesi N, Panahi P, Karimi A Tags: Curr Pharm Des Source Type: research

Mesenchymal Stem Cell Therapy For Ischemic Heart Disease: Advances And Challenges.
Abstract Ischemic heart disease (IHD) has been recognized as the main cause of mortality in the modern world. Application of cell therapy technologies for the IHD treatment has been actively studied from the beginning of 2000s. The review is dedicated to the use of mesenchymal stem cells (MSC) in the therapy of IHD. The strategies of the MSC modification in vitro for improvement of their regenerative potential are extensively discussed, including preconditioning to enhance the cell survival, boosting their paracrine effect, manipulating their cardiomyogenic differentiation. The optimization of the MSC delivery and...
Source: Current Pharmaceutical Design - September 13, 2018 Category: Drugs & Pharmacology Authors: Konoplyannikov M, Kotova S, Baklaushev V, Konoplyannikov A, Kalsin V, Timashev P, Troitsky A Tags: Curr Pharm Des Source Type: research

Metabolomics in Vitamin Status Assessment.
Abstract The issue of vitamin deficiency persists to be a major health issue worldwide despite the advancements in medicine. At the same time, the effect of marginal vitamin deficiency status on physiological processes is proven. However, general methods such as immune-enzyme and fluorescence analysis, microbiological assays, for example, have limitations in vitamin status assessment and are not able to reliably reflect personal vitamin demand. The potential usefulness of modern metabolomics methods in vitamin status assessment is described in this review. These methods can be used for vitamin metabolites detectio...
Source: Current Pharmaceutical Design - September 12, 2018 Category: Drugs & Pharmacology Authors: Yurgita RV, Livantsova NE, Ukrainets VI, Kosyura DS, Starodubova VA Tags: Curr Pharm Des Source Type: research

Effect of dapagliflozin on intestinal flora in MafA-deficient mice.
Abstract OBJECTIVE: To investigate the effect of dapagliflozin on intestinal microflora in MafA-deficient mice by establishing an animal model of diabetes. METHODS: Male MafA knockout mice were given intragastrically with dapagliflozin (1.0 mg/kg/d) for 6 weeks. Body weights and fasting blood glucose levels were measured in mice, and their intestinal short-chain fatty acids were measured by gas chromatography. At the same time, a plate count method was used to analyze the number of main harmful bacteria in the feces and the high-throughput sequencing was used to sequence the changes of intestinal flora. ...
Source: Current Pharmaceutical Design - September 12, 2018 Category: Drugs & Pharmacology Authors: Li L, Xu S, Guo T, Gong S, Zhang C Tags: Curr Pharm Des Source Type: research

Pharmaceutical potentialities of β-caryophyllene for drug delivery systems: a prospection.
CONCLUSION: This prospective study evidenced the new perspectives related to BCP vectorization systems in the pharmaceutical and industrial marketing field and may serve as a basis for further research and pharmaceutical use of this powerful cannabinoid. PMID: 30207226 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 12, 2018 Category: Drugs & Pharmacology Authors: Santos PS, Oliveira TC, R Júnior LM, Nunes LCC Tags: Curr Pharm Des Source Type: research

Medicinal plants and atherosclerosis: A review on molecular aspects.
Abstract Atherosclerosis is an inflammatory vascular disease that is characterized by progressive accumulation of cholesterol in the arterial walls and it is a major cause of cardiovascular disease. Issues related to the side effects of synthetic drugs have in recent times, led to the misuse of drugs, a lack of patient consultations, and consequently, a disruption in meticulous disease control. Therefore, a new insight into medicinal plants has recently emerged and much research has been conducted on these herbs in an attempt to prepare novel naturally based drugs. The aim of this review article was to scrutinize ...
Source: Current Pharmaceutical Design - September 11, 2018 Category: Drugs & Pharmacology Authors: Gholipour S, Sewell RDE, Lorigooini Z, Rafieian-Kopaei M Tags: Curr Pharm Des Source Type: research

Tumor necrosis factor- α and C-C motif chemokine ligand 18 associate with atherosclerotic lipid accumulation in situ and in vitro.
Tumor necrosis factor-α and C-C motif chemokine ligand 18 associate with atherosclerotic lipid accumulation in situ and in vitro. Curr Pharm Des. 2018 Sep 11;: Authors: Orekhov AN, Nikiforov NG, Elizova NV, Korobov GA, Aladinskaya AV, Sobenin IA, Bobryshev YV Abstract Disorders of the innate immune system and associated cytokine disturbances play an important role in atherosclerosis. Although both pro- and anti-inflammatory cytokines have been detected in human atherosclerotic lesions, quantitative data on their expression in early atherosclerotic lesions remains to be reported. We studied local...
Source: Current Pharmaceutical Design - September 11, 2018 Category: Drugs & Pharmacology Authors: Orekhov AN, Nikiforov NG, Elizova NV, Korobov GA, Aladinskaya AV, Sobenin IA, Bobryshev YV Tags: Curr Pharm Des Source Type: research

Modified Ldl Particles Activate Inflammatory Pathways In Monocyte-Derived Macrophages: Transcriptome Analysis.
Abstract A hallmark of atherosclerosis is its complex pathogenesis, which is dependent on altered cholesterol metabolism and inflammation. Both arms of pathogenesis involve myeloid cells. Monocytes migrating into the arterial walls interact with modified low-density lipoprotein (LDL) particles, accumulate cholesterol and convert into foam cells, which promote plaque formation and also contribute to inflammation by producing pro-inflammatory cytokines. A number of studies characterized transcriptomics of macrophages following interaction with modified LDL, and revealed alteration of the expression of genes responsi...
Source: Current Pharmaceutical Design - September 11, 2018 Category: Drugs & Pharmacology Authors: Orekhov AN, Oishi Y, Nikiforov NG, Zhelankin AV, Dubrovsky L, Sobenin IA, Kel A, Stelmashenko D, Makeev VJ, Foxx K, Jin X, Kruth HS, Bukrinsky M Tags: Curr Pharm Des Source Type: research

Coronary microcirculation and the no-reflow phenomenon.
Abstract The no-reflow phenomenon refers to the post-percutaneous coronary intervention condition in which, despite re-establishing epicardial coronary vessel patency, the flow to the previously ischemic myocardium is markedly reduced. When it does occur, it attenuates the beneficial effect of reperfusion therapy and substantial regions of the myocardium fail to receive adequate perfusion. The pathophysiology of this phenomenon is not completely understood. The possible mechanisms could be related to alterations in the microvascular circulation. Various mechanisms such as activation of inflammatory pathways, vascu...
Source: Current Pharmaceutical Design - September 11, 2018 Category: Drugs & Pharmacology Authors: Oikonomou E, Mourouzis K, Vogiatzi G, Siasos G, Deftereos S, Papaioannou S, Latsios G, Tsalamandris S, Tousoulis D Tags: Curr Pharm Des Source Type: research

Translation of Basic Research into Clinics: Killer Immunoglobulin-like Receptors Genes in Autoimmune and Infectious Diseases.
Abstract Killer immunoglobulin-like receptors regulate the activation of natural killer cells through their interaction with human leucocyte antigens. Killer immunoglobulin-like receptors and human leucocyte antigens loci are highly polymorphic, and some their combinations have been found to protect against viral infections or to predispose to autoimmune disorders. In particular, some activating killer immunoglobulin-like receptors profiles may be detrimental in autoimmune pathogenesis, and specific killer immunoglobulin-like receptors genes may be particularly aggressive in the clearance of different microorganis...
Source: Current Pharmaceutical Design - September 11, 2018 Category: Drugs & Pharmacology Authors: Aiello A, Candore G, Accardi G, Caruso C, Colomba C, Duro G, Gambino CM, Ligotti ME, Di Bona D Tags: Curr Pharm Des Source Type: research

The dual specificity role of transcription factor FOXO in type 2-diabetes and cancer.
Abstract The FOXO (Forkhead box O) transcription factors are implicated in several signaling pathways and play a vital role in various cellular and physiological processes include, for instance, ROS (reactive oxygen species) response, cell proliferation, regulation of programmed cell death, longevity, metabolism and cancer and regulation of cell cycle. In humans, four FOXO members resemble similar structure and are known for their role in both regulation and functions. FOXO1 gene is highly expressed in adipose tissues and it affects the regulation of glycogenolysis and gluconeogenesis through insulin signaling. Th...
Source: Current Pharmaceutical Design - September 10, 2018 Category: Drugs & Pharmacology Authors: Fatima K, Mathew S, Faheem M, Mehmood T, Yassine HM, Al Thani AA, Abdel-Hafiz H, Al Ghamdy K, Qadri I Tags: Curr Pharm Des Source Type: research

Medicinal plants for the treatment of hair loss and the suggested mechanisms.
Abstract Hair loss may not be recognized as a life-threatening disorder. However, it has a great harm on a person's self-respect, mental health, and entirety quality of life. Androgenic alopecia (AGA) is the most common type of hair loss, which affects a great number of both men and women. Alopecia can be treated with various hair loss strategies, including hair transplant, cosmetics and medication. Medical treatment shows the outstanding ability in improving hair growth. Plenty of drugs prevent alopecia by inhibiting the secretion of male hormone. But these medicines exhibit some undesirable side effects. Since h...
Source: Current Pharmaceutical Design - September 10, 2018 Category: Drugs & Pharmacology Authors: Shen YL, Li XQ, Pan RR, Yue W, Zhang LJ, Zhang H Tags: Curr Pharm Des Source Type: research

Diagnostics and Therapy of human diseases - Focus on sialidases.
Abstract Sialic acid residues that make part of the cell surface repertoire of carbohydrate residues are implicated in various physiological processes and human pathologies. Sialidases, or neuraminidases, are the enzymes that are able to cleave and release the sialic acid residues, while trans-sialidases can transfer the residues from donor to acceptor molecules. They are important for processing the surface glycolipids and glycoproteins. Therapeutic potential of pharmacological sialidases inhibition is currently actively studied. Knowledge and expertise gained from genetic defects leading to human sialidase defic...
Source: Current Pharmaceutical Design - September 10, 2018 Category: Drugs & Pharmacology Authors: Karagodin VP, Sukhorukov VN, Myasoedova VA, Grechko AV, Orekhov AN Tags: Curr Pharm Des Source Type: research

Does HbA1cc Play a Role in the Development of Cardiovascular Diseases?
In conclusion, HbA1c serves as a useful marker for diagnosis and management of diabetes. AGE cannot replace HbA1c in the diagnosis and management of diabetes. There is an association of HbA1c with CVD which be mediated through modulation of CVD risk factors. PMID: 30179123 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Prasad K Tags: Curr Pharm Des Source Type: research

Protein-derived smart materials for medical applications: elastin-like polypeptides.
Abstract A group of stimulus-responsive biopolymers developed from the hydrophobic domain of tropoelastin are collectively known as elastin-like polypeptides (ELPs). These peptides generally consist of repeated pentapeptide units of the form (VPGXG)n, where X can be any amino acid with the exception of proline. ELPs present wide-ranging possibilities in biomedicine due to their many beneficial characteristics, including tunable phase transition behavior and biological compatibility, along with the absence of immunogenic and pyrogenic characteristics. The present paper reviews the physicochemical characteristics of...
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Lin R, Wang S, Liu W Tags: Curr Pharm Des Source Type: research

Computer-aided drug design and drug pharmacokinetic prediction: a mini-review.
Abstract Prediction of pharmacokinetics and drug targeting is a challenge in drug design. There are different types of software that can help predicting the pharmacokinetic profile of a drug. Quantitative structure-activity relationship (QSAR) modeling is used for drug design with less cost. Drug-excipient interactions are predicted by docking tools. Computerized drug target prediction and docking programs offer additional options to predict potential effects and adverse reactions of a given candidate as well as the best orientation of the compound on the receptor active site. Information on the absorption, distri...
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Tabeshpour J, Sahebkar A, Zirak MR, Zeinali M, Hashemzaei M, Rakhshani S, Rakhshani S Tags: Curr Pharm Des Source Type: research

Cardiac Stem Cell Characteristics in Physiological and Pathological Conditions.
Abstract For nearly a century, the adult heart was considered as a post-mitotic organ. The discovery of a resident cardiac stem cell (CSC) population in the heart has dramatically undermined this notion with the support of encouraging preclinical and clinical studies aiming to regenerate the damaged heart after a myocardial infarction (MI). There are two ways to obtain CSCs for transplantation: Allogeneic and autologous sources. Autologous cells may be obtained from the patients' own tissue. Obtaining cells from diseased patients may contain a risk for altered stem cell characteristics. In addition to MI, these pa...
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Ozturk S, Elcin YM Tags: Curr Pharm Des Source Type: research

Mitochondria and the Pathophysiological Mechanism of Atrial Fibrillation.
Abstract Atrial fibrillation (AF) is the most common and significant cardiac arrhythmia in clinical practice, however the pathophysiological mechanism of AF has not been fully explained. At present, there are no available treatment options can target the underlying pathophysiological processes of AF. Research on improving management strategies for AF can start with a further understanding of the changes of cells in AF. Mitochondria play central roles in the function of cardiac myocytes and many of the pathophysiological processes implicated in AF are relative to mitochondrial function, including formation of react...
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Li X, Yang X, Li Y, Yuan M, Tian C, Yang Y, Zhang X, Liu C, Gao Y, Liu N, Shang H, Xing Y Tags: Curr Pharm Des Source Type: research

Role of Methylglyoxal in Diabetic Cardiovascular and Kidney Diseases: Insights from Basic Science for Application into Clinical Practice.
CONCLUSION: Reducing MG levels directly using scavengers or indirectly via activation of Nrf2/Glo1 may serve as a novel and potent therapeutic strategy to counter the deleterious effects of MG in diabetic complications. PMID: 30179128 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Sankaralingam S, Ahmed A, Rahman M, Eid AH, Munusamy S Tags: Curr Pharm Des Source Type: research

Cell-based therapy for hypertension: challenges and perspectives.
Abstract Hypertension is a non-transmissible chronic disease with a high prevalence, morbidity, and mortality. Different strategies for the treatment of hypertension are employed worldwide, but the control of hypertension remains a major challenge for global health. Many unsuccessful unconventional therapies have been proposed in recent years, including herbal medicines and the development of small molecules or antibodies that seek to disrupt the disease's pathogenesis. Cell-based therapies may be used as replacement or complementary treatment strategies. The results of recent preclinical studies of cell-based the...
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Gasparotto A, Dos Reis FA Tags: Curr Pharm Des Source Type: research

Mechanisms and Treatments of Oxidative Stress in Atrial Fibrillation.
Abstract Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious diseases and is an increasing health-care burden. AF is associated with an excess amount of reactive oxygen species. In this review, we summarize several possible reactive oxygen species pathways that induce AF based on atrial electrical and structural remodeling data. The sources and factors implicated in AF-related oxidative stress include NADPH oxidase activation, calcium overloading and mitochondrial damage, angiotensin system activation, nitric oxide synthase uncoupling, and xanthine oxidase activation-as...
Source: Current Pharmaceutical Design - September 3, 2018 Category: Drugs & Pharmacology Authors: Ren X, Wang X, Yuan M, Tian C, Li H, Yang X, Li X, Li Y, Yang Y, Liu N, Shang H, Gao Y, Xing Y Tags: Curr Pharm Des Source Type: research

Effect of Paclitaxel-Loaded PLGA Nanoparticles on MDA-MB Type Cell Lines; Apoptosis and Cytotoxicity Studies.
Abstract Triple-Negative Breast Cancer is an aggressive type of breast cancer, unable to treat by using chemotherapy drugs, due lack of Estrogen Receptor (ER), Progesterone Receptor (PR) expression and Human Epidermal Growth Factor Receptor 2 (HER2) on the cell surface. The aim of this study was to compare the effect of paclitaxel-loaded PLGA nanoparticle (PTX-NPs) on the cytotoxicity and apoptosis of the different MDA-MB type of cell lines. PTX-NPs were prepared by nanoprecipitation method and characterized earlier. The cytotoxicity of PTX-NPs was evaluated by MTT and LDH assay, later apoptosis was calculated by ...
Source: Current Pharmaceutical Design - September 2, 2018 Category: Drugs & Pharmacology Authors: Vijayan V, Shalini K, Yugesvaran V, Yee TH, Balakrishnan S, Palanimuthu VR Tags: Curr Pharm Des Source Type: research

Chemical constituents and pharmacological activities of Stellera Chamaejasme.
CONCLUSIONS: A large number of studies conclude that S. Chamaejasme displays a wide spectrum of pharmacological activity with the anti-tumor activity being significant. PMID: 30179119 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 2, 2018 Category: Drugs & Pharmacology Authors: Li XQ, Rahman K, Zhu JY, Zhang H Tags: Curr Pharm Des Source Type: research

Sulfur mustard-related ocular complications: a review of proteomic alterations and pathways involved.
In this study, we reviewed SM-related proteomic alterations and the association of the found proteins with other eye disorders and diseases. Furthermore, using pathway enrichment analysis, we found the most central biological processes involved in the emergence of complications caused by SM. Our results revealed that deficient cellular homeostasis, especially in terms of iron-dependent regulations, as well as pathological changes in vascular endothelial growth factor (VEGF) expression, are the most central biological processes involved in eye injuries caused by SM. PMID: 30179120 [PubMed - as supplied by publisher] (S...
Source: Current Pharmaceutical Design - September 2, 2018 Category: Drugs & Pharmacology Authors: Panahi Y, Shahbazi A, Naderi M, Jadidi K, Sahebkar A Tags: Curr Pharm Des Source Type: research

The Mechanism of Exosomes Function in Neurological Diseases: a progressive review.
Abstract Exosomes are extracellular microparticles (≈30-100 nm in diameter) secreted from nearly all types of cells, containing a whole set of biological information including proteins, ribonucleic acid (RNA) and lipids. Latest studies show that exosomes contribute to cell-cell communication and are considered closely related with the modulation of angiogenesis and neurogenesis in many neurological diseases. In past decade, numerous researchers were devoted to exosomes study, but the mechanism of exosomes function and delivery is uncertain. In this review, we summarized several potential mechanisms of exosom...
Source: Current Pharmaceutical Design - September 2, 2018 Category: Drugs & Pharmacology Authors: Yuan M, Liu N, Wang X, Tian C, Ren X, Zhang H, Li X, Zhu H, Zhu L, Shang H, Xing Y, Gao Y Tags: Curr Pharm Des Source Type: research

The role of epigenetic alterations involved in sepsis: An overview.
CONCLUSION: Epigenetic processes involve specific enzymes detected in the blood and other body fluids which can potentially serve as diagnostic, therapeutic, as well as prognostic tools in sepsis. Epigenetic mechanisms can provide highly sensitive and accurate method for sepsis diagnosis using blood and other body fluids. PMID: 30179122 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - September 2, 2018 Category: Drugs & Pharmacology Authors: Hassan FI, Khan F, Mojtahedzadeh M, Abdollahi M Tags: Curr Pharm Des Source Type: research

Potential Prognostic, Diagnostic And Therapeutic Markers For In-stent Reocclusion In Advanced Age Patients After Coronary Stenting.
Abstract Oxidative stress and inflammatory response played important roles in advanced atherosclerosis. We tried to confirm clinical diagnostic significance of the assessments of oxidative stress and inflammatory response status with in-stent reocclusion in 283 advanced age patients (80~90 years) after coronary stenting. We analyzed levels of circulating superoxide dismutase 3 (SOD3), nitric oxide (NO), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA) , acrolein(ACR), and paraoxonase-1 (PON-1)in advanced age patients with in-stent reocclusion after coronary stenting. Levels of SOD3, eNOS, ...
Source: Current Pharmaceutical Design - August 30, 2018 Category: Drugs & Pharmacology Authors: Li X, Zhang F, Zhou H, Hu Y, Fang X, Guo D, Chen Y Tags: Curr Pharm Des Source Type: research

Concept of Hematopoietic and Stromal Niches for Cell-Based Diagnostics and Regenerative Medicine (a Review).
CONCLUSION: We speculated our definition of the stem cell niche, proposed and described certain stages (postulation; morphofunctional; topographical; quantitative; bioengineering) of the niche theory development. Prospective directions of the niche designing for cell-based diagnostics and regenerative medicine were noted. PMID: 30160210 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 29, 2018 Category: Drugs & Pharmacology Authors: Khlusov IA, Litvinova LS, Khlusova MY, Yurov KA Tags: Curr Pharm Des Source Type: research

The effects of curcumin on glycemic control and lipid profiles among patients with metabolic diseases: a systematic review and meta-analysis of randomized controlled trials.
Abstract This systematic review and meta-analysis of randomized controlled trials (RCTs) was performed to determine the influence of curcumin intake on glycemic status and lipid profiles of patients with metabolic diseases. We searched the following databases up until January 2018: MEDLINE, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials. The relevant data were extracted and evaluated for quality of the studies in accordance with the Cochrane risk of bias tool. Data were pooled using the inverse variance method and expressed as standardized mean difference (MDs) with 95% confidence inter...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Tabrizi R, Vakili S, Lankarani KB, Akbari M, Mirhosseini N, Ghayour-Mobarhan M, Ferns G, Karamali F, Karamali M, Taghizadeh M, Kouchaki E, Asemi Z Tags: Curr Pharm Des Source Type: research

Role of Regulatory T Cells in Infection and Vaccination During Early Infancy.
Abstract Reducing infant mortality due to infectious diseases is one of the most important public health goals worldwide. Several approaches have been implemented to reach this goal and vaccination has been an effective strategy for reducing infant and newborn mortality. However, the immunological features of neonates and infants represent a significant barrier to the effectiveness of vaccination. Since regulatory T cells (Treg cells) are known to play an active role in contributing to various mechanisms of suppression of the immune cell function, it has been proposed that these immune cells could decrease the imm...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Funes SC, Mansilla MA, Canedo-Marroquin G, Lay MK, Riedel CA, Kalergis AM Tags: Curr Pharm Des Source Type: research

The anticancer effect of Sanguinarine, a review.
Abstract In vitro and in vivo studies have revealed that Sanguinarine has antioxidant, anti-inflammatory, proapoptotic, and growth inhibitory effects on tumor cells of a variety of cancers. Previous research showed that sanguinarine induced apoptosis (cell death) and/or antiproliferattin, while reducing tumor cell antiangiogenic and anti-invasive properties. This paper describes various sanguinarine anti-cancer mechanisms, including inhibition of erroneously-activated signal transduction pathways, apoptosis, and tumor cell proliferation inhibition. PMID: 30156147 [PubMed - as supplied by publisher] (Source: ...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Fu C, Guan G, Wang H Tags: Curr Pharm Des Source Type: research

Individualized Tacrolimus Therapy for Pediatric Nephrotic Syndrome: Considerations for Ontogeny and Pharmacogenetics of CYP3A.
Abstract Tacrolimus is used initially as an immunosuppressant drug in solid organ transplant population. This calcineurin inhibitor has also been recommended by KDIGO Clinical Practice Guideline for Glomerulonephritis for the treatment of nephrotic syndrome in children and adults. Tacrolimus is characterized by a narrow therapeutic index and large pharmacokinetic (PK) variations. Therefore, routine therapeutic drug monitoring (TDM) is critical to keep tacrolimus blood levels within therapeutic range. Tacrolimus is mainly metabolized by cytochrome P450 (CYP) enzymes 3A5 and 3A4. Actually, for pediatric patients, th...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Sun JY, Xu ZJ, Sun F, Guo HL, Ding XS, Chen F, Xu J Tags: Curr Pharm Des Source Type: research

Chinese herbal formulas and renal fibrosis: An overview.
Abstract All forms of chronic kidney disease (CKD) eventually lead to renal fibrosis irrespective of its origin. It is generally characterized by an excessive accumulation and deposition of extracellular matrix (ECM) and to date no ideal treatment has been established. Bian-Zheng-Lun-Zhi (syndrome differentiation and treatment), a classic feature of traditional Chinese Medicine (TCM), is a unique method used to diagnose and treat the pathology of a disease. Zheng (syndrome) is used to demonstrate the nature of a disease completely in an extensive and specific manner. Chinese herbal formulas are determined accordin...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Shen YL, Wang SJ, Rahman K, Zhang LJ, Zhang H Tags: Curr Pharm Des Source Type: research

Effects of bioactive peptide on Inflammatory Bowel Disease, focus on signal transduction and intestinal microbiota.
Abstract Inflammatory bowel diseases (IBD) is now widely receiving attention. There are many reasons why people get IBD; for example, environment, smoking, family heredity, intestinal microbiota and so on. Antibiotics have not proved effective and those suffering from IBD have begun to look for other effective drugs to treat the chronic disease. Bioactive peptides are a good candidate among alternative drugs tested so far, and have been seen to control bodily growth, development, immune regulation and metabolism. This paper will review the literature describing the effects of bioactive peptides on intestinal infla...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Ma Y, Yan W, Ding S, Fei Y, Liu G, Fang J Tags: Curr Pharm Des Source Type: research

Immunosuppression-lipid metabolism interplay and medicinal plants in atherosclerosis: a review.
Abstract Atherosclerosis is a chronic arterial disease responsible for the majority of vascular-related deaths throughout the world. Immune cells and inflammation in conjunction with hyperlipidemia play a key role in atherosclerosis development. Regarding the low efficacy of the synthetic drugs and also the associated negative side effects which can adversely influence health-related quality of life, looking for natural, affordable and non-toxic substances seem necessary. Plant-derived natural products play a critical role in prevention and treatment of atherosclerosis. In this review, we aimed to outline the most...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Moradi F, Sewell RDE, Lorigooini Z, Rafieian-Kopaei M Tags: Curr Pharm Des Source Type: research

Therapeutic potential of DNA-aptamers raised against AGE-RAGE axis in diabetes-related complications.
Abstract Accumulating evidence has indicated that formation and accumulation of advanced glycation end products (AGEs) progress under diabetic conditions, thereby contributing to the development and progression of various diabetes- and aging-related disorders, such as diabetic nephropathy, diabetic retinopathy, atherosclerotic cardiovascular disease, insulin resistance, cancer growth and metastasis, osteoporosis, and Alzheimer's disease. Modification of proteins, lipids and nucleic acids by AGEs alter their structural integrity and function, and evoke oxidative stress generation and inflammatory reactions through ...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Yamagish SI, Matsui T Tags: Curr Pharm Des Source Type: research

Meta-analysis of clinical outcomes of electrical cardioversion and catheter ablation in patients with atrial fibrillation and chronic kidney disease.
Abstract BACKGROUND: Chronic kidney disease (CKD) is associated with adverse outcomes in presence of atrial fibrillation (AF). However, the literature shows limited data on non-pharmacological management of AF in CKD patients. AIM: summarizing the available data on outcomes associated with electrical cardioversion (ECV) and AF catheter ablation (CA) in CKD patients. METHODS: We searched MEDLINE and the Cochrane Central Register of Controlled Trials and performed a meta-analysis. The primary outcome was recurrence of AF. The secondary outcomes were occurrence of thromboembolic events (TEs) and estimated g...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Diemberger I, Genovesi S, Massaro G, Reggiani MLB, Frisoni J, Gorlato G, Mauro E, Padeletti M, Vincenti A, Boriani G Tags: Curr Pharm Des Source Type: research

Current approaches to engineering of NK cells for cancer immunotherapy.
Abstract Natural killer (NK) cells belong to a unique subtype of lymphocytes with a great potential for cancer immunotherapy due to their ability to rapidly recognize and efficiently kill tumor cells. Their anti-cancer potential can be further increased by genetic and non-genetic modifications. However, the attempts of genetic improvements of NK cells over the past 20 years have been hampered by the difficulties of gene delivery into this cell type, thus preventing researchers from producing clinically relevant numbers of viable and biologically active NK cells. Currently, several successful approaches to genetic ...
Source: Current Pharmaceutical Design - August 28, 2018 Category: Drugs & Pharmacology Authors: Streltsova MA, Barsov EV, Erokhina SA, Sapozhnikov AM, Kovalenko EI Tags: Curr Pharm Des Source Type: research

Management of Erectile Dysfunction: An Under-Recognition Of Hypertension.
CONCLUSION: Understanding of common mechanisms involved in ED accompanied with hypertension and the research on antihypertensive drugs that impact ED will bring important approaches for identifying novel therapeutic strategies that will improve quality of life in patients with these conditions. PMID: 30152279 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 27, 2018 Category: Drugs & Pharmacology Authors: Koroglu G, Kaya-Sezginer E, Yilmaz-Oral D, Gur S Tags: Curr Pharm Des Source Type: research

Herbal and Holistic solutions for Neurodegenerative and Depressive disorders: Leads from Ayurveda.
Abstract Neuropsychiatric and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease, depression, epilepsy, schizophrenia, and anxiety pose a major public health problem and are associated with the considerable burden of disease, suicides, physical comorbidities, high economic costs, and poor quality of life. There is a recent upsurge in global interest toward the field of herbal or traditional medicine and these drugs are gaining popularity both in developing and developed countries because of their natural origin and fewer side effects. On the contrary, conventional synthetic drugs have bee...
Source: Current Pharmaceutical Design - August 21, 2018 Category: Drugs & Pharmacology Authors: Sharma R, Kabra A, Rao MM, Prajapati PK Tags: Curr Pharm Des Source Type: research

Thioredoxin as a therapeutic target in cerebral ischemia.
CONCLUSION: In conclusion, Trx has a potential neuroprotection in cerebral ischemia and may be very promising for clinical therapy of ischemic stroke in the future. PMID: 30124144 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 20, 2018 Category: Drugs & Pharmacology Authors: Zeng XS, Geng WS, Chen L, Jia JJ Tags: Curr Pharm Des Source Type: research

Cordycepin modulates body weight by reducing prolactin via an adenosine A1 receptor.
In this study, we explored the molecular mechanism of the anti-obesity effect of cordycepin. In vivo, obese rats model was induced by high fat diet for 5 weeks, the serum and liver lipids coupled with serum prolactin were reduced by treatment of cordycepin (P<0.01) , the results suggested that cordycepin is a potential drug for lowering blood and liver lipids and reducing body weight which related with prolactin. Cordycepin also protects adipocytes from enlargement and hepatocytes from lipotoxicity caused inflammation. In vitro, cordycepin could inhibit prolactin secretion in GH3 cells via upregulating the expression of ...
Source: Current Pharmaceutical Design - August 20, 2018 Category: Drugs & Pharmacology Authors: Li Y, Li Y, Wang X, Xu H, Wang C, An Y, Luan W, Wang X, Li S, Ma F, Ni L, Liu M, Tang X, Yu L Tags: Curr Pharm Des Source Type: research

Emerging and alternative therapies for Parkinson disease: an updated review.
Abstract Parkinson's disease (PD) is one of the most common neurodegenerative disorder with intricate progressive pathology. Currently, available conventional options for PD have certain limitations of their own, and as a result, patient compliance and satisfaction are low. Current contemporary treatment options provide only symptomatic relief with limited control to prevent disease progression, resulting in poor patient compliance and satisfaction. Several emerging pharmacotherapies for PD are in different stages of clinical development. These therapies include adenosine A2A receptor antagonists, glutamate recept...
Source: Current Pharmaceutical Design - August 20, 2018 Category: Drugs & Pharmacology Authors: Kabra A, Sharma R, Kabra R, Baghel US Tags: Curr Pharm Des Source Type: research

A comparison of proliferation of human mesenchymal stem cells derived from adipose tissue treated with human full-length amelogenin and C-terminal amelogenin peptide.
In this study, we examined the effects of human full-length amelogenin (rh174) and amelogenin C-terminal peptide (amgCP) on the proliferation of ADSCs. ADSCs were cultured in the presence of amgCP or rh174. Cell proliferation was analyzed using BrdU immunoassay and MTS assay. Cell migration was evaluated by ELISA. The MAPK-ERK pathway was examined by phospho-p44/42 MAPK (Thr202/Tyr204) sandwich ELISA and western blotting. A specific MAPK inhibitor, U0126, was used to block ERK activity. ADSC proliferation and migration were significantly (P
Source: Current Pharmaceutical Design - August 15, 2018 Category: Drugs & Pharmacology Authors: Ando K, Kunimatsu R, Awada T, Yoshimi Y, Tsuka Y, Sumi K, Horie K, Abe T, Nakajima K, Tanimoto K Tags: Curr Pharm Des Source Type: research

The possible impact of hyperuricemia on serum soluble receptor for advanced glycation end products (sRAGE) levels in teenagers: a case control study.
This study was set out to assess, whether there was any association between serum sRAGE level and serum uric acid level in children with hyperuricemia Methods This case control study involved 53 patients (12 girls, 41 boys) with hyperuricemia (defined as serum uric acid >4.8 and >5.5 mg/dl in girls and boys, respectively) aged median of 13.5-15.5 years. Thirty-six healthy individuals with normal serum uric acid level were selected as a reference group. Additionally the study group with hyperuricemia was divided into two groups: HU-HT (hypertensive n=25) and HU-NT (normotensive n=28) teenagers. The serum...
Source: Current Pharmaceutical Design - August 12, 2018 Category: Drugs & Pharmacology Authors: Lemiesz M, Tenderenda-Banasiuk E, Sosnowska D, Rybi-Szuminska A, Storonowicz J, Lemiesz T, Wasilewska A Tags: Curr Pharm Des Source Type: research

Redox sensitive polysaccharide based nanoparticles for improved cancer treatment: A comprehensive review.
CONCLUSION: According to the reviewed papers, the efficiency of diverse redox-responsive polysaccharide-based nanoparticles with therapeutic payloads in cancer chemotherapy could be concluded. Nevertheless, more comprehensive studies are required to understand the exact intracellular and systemic fate of these nano-carriers, as well as their clinical efficacy for cancer treatment. PMID: 30101696 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 12, 2018 Category: Drugs & Pharmacology Authors: Ghassami E, Varshosaz J, Taymouri S Tags: Curr Pharm Des Source Type: research

The influence of silicone oil on the ganglion cell complex after pars plana vitrectomy for rhegmatogenous retinal detachment.
Abstract PURPOSE: Pars plana vitrectomy (PPV) and silicone oil endotamponade has been used as a treatment in rhegmatogenous retinal detachment (RRD). Improvement in the modality of spectral-domain optical coherence tomography (SD-OCT) allows for the assessment of ganglion cell layer-inner plexiform layer (GCL-IPL) in the macular region. Information about the GCL-IPL status may be a response to the question why the visual recovery after PPV with silicone oil tamponade is incomplete. The aim of the study was to evaluate the impact of silicone oil on GCL-IPL and compare it with other endotamponade types such as Sulfu...
Source: Current Pharmaceutical Design - August 12, 2018 Category: Drugs & Pharmacology Authors: Raczynska D, Mitrosz K, Raczynska K Tags: Curr Pharm Des Source Type: research

Understanding the binding mechanism of Amyloid- β inhibitors from molecular simulations.
Understanding the binding mechanism of Amyloid-β inhibitors from molecular simulations. Curr Pharm Des. 2018 Aug 12;: Authors: Tran L Abstract In recent years, Aβ aggregation prevention, one of the most concerned strategies in drug development has been carefully assessed to treat Alzheimer's disease. Aβ peptides can transform structurally from random coil monomer into β-stranded protofibril via multiple oligomeric states. Among the various Aβ species, the identification of binding targets has been challenging due to the heterogeneousity and metastable nature. A better understa...
Source: Current Pharmaceutical Design - August 12, 2018 Category: Drugs & Pharmacology Authors: Tran L Tags: Curr Pharm Des Source Type: research

Improvement of stability of tea polyphenols: a review.
Abstract Tea polyphenols have received much attention from the pharmaceutical and food industries owing to their extraordinary antioxidant and antibacterial characteristics. However, tea polyphenols are very unstable to processing and storage, since they are sensitive to the environmental factors like temperature, light and pH. Therefore, the effective application of tea polyphenols requires a protective mechanism to maintain its activity. The utilization of compounded tea polyphenols, instead of raw materials, can potentially help to improve their stability. This review focuses on the summarization of the compoun...
Source: Current Pharmaceutical Design - August 10, 2018 Category: Drugs & Pharmacology Authors: Sun B, Wang W, He Z, Zhang M, Kong F, Sain M, Ni Y Tags: Curr Pharm Des Source Type: research

The Development of Pharmacophore Modeling: Generation and Recent Applications in Drug Discovery.
CONCLUSIONS: Owing to its' convenience and efficiency, pharmacophore presents an essential method for drug discovery. PMID: 30101699 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - August 10, 2018 Category: Drugs & Pharmacology Authors: Lu X, Yang H, Chen Y, Li Q, He SY, Jiang X, Feng F, Qu W, Sun H Tags: Curr Pharm Des Source Type: research