Research Progress of Raman Spectroscopy and Raman Imaging in Pharmaceutical Analysis
Curr Pharm Des. 2022 May 18. doi: 10.2174/1381612828666220518145635. Online ahead of print.ABSTRACTThe analytical investigation of the pharmaceutical process monitors the critical process parameters of the drug, beginning from its development until marketing and postmarketing, and appropriate corrective action can be taken to change the pharmaceutical design at any stage of the process. Advanced analytical methods, such as Raman spectroscopy, are particularly suitable for use in the field of drug analysis, especially for qualitative and quantitative work, due to the advantages of simple sample preparation, fast, nondestruc...
Source: Current Pharmaceutical Design - May 20, 2022 Category: Drugs & Pharmacology Authors: Jie Ren Shijie Mao Jidong Lin Ying Xu Qiaoqiao Zhu Ning Xu Source Type: research

Insights into new therapeutic approaches for the treatment and management of polycystic ovary syndrome: An updated review
CONCLUSION: Exhaustive, multicentric and multiethnic studies are vital to generate a network of normative data to better figure out the PCOS trajectory and change prognostic outcomes. Preclinical and clinical data is warranted to corroborate the new therapeutics and direct health care resources accordingly.PMID:35593345 | DOI:10.2174/1381612828666220518150754 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 20, 2022 Category: Drugs & Pharmacology Authors: Rohina Bashir Imtiyaz A Wani Mohd Ashraf Ganie Source Type: research

Alginate-based Composites Microspheres: Preparations and Applications for Bone Tissue Engineering
Curr Pharm Des. 2022 May 18. doi: 10.2174/1381612828666220518142911. Online ahead of print.ABSTRACTAlginate-based biomaterials have been extensively studied for bone tissue engineering. Scaffolds, microspheres, and hydrogels can be developed using alginate, which is biocompatible, biodegradable, and able to deliver growth factors and drugs. Alginate microspheres can be produced using crosslinking, microfluidic, three-dimensional printing, extrusion, and emulsion methods. The sizes of the alginate microspheres range from 10 µm to 4 mm. This review describes the chemical characterization and mechanical assessment of alginat...
Source: Current Pharmaceutical Design - May 20, 2022 Category: Drugs & Pharmacology Authors: Jayachandran Venkatesan Sesha Subramanian Murugan Pandurang Ad Yashaswini Dgv Gi Hun Seong Source Type: research

Immune Checkpoint Inhibitor-Induced Thyroid Disorders: a Single Center Experience
CONCLUSIONS: Our results confirm that patients undergoing immunotherapy should be monitored for potential thyroid dysfunction with biochemical assessments and changing in thyroid volume estimated by ultrasound could be helpful in the diagnostic work-up.PMID:35593347 | DOI:10.2174/1381612828666220518151509 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 20, 2022 Category: Drugs & Pharmacology Authors: Armando Patrizio Poupak Fallahi Alessandro Antonelli Silvia Martina Ferrari Source Type: research

Diammonium glycyrrhizinate preparation for liver function recovery in chronic hepatitis B in China: a meta-analysis with trial sequential analysis
CONCLUSION: To our knowledge, this was the first relatively complete meta-analysis and systematic evaluation of the efficacy of DG intervention for CHB; liver-function recovery was discussed in the context of traditional Chinese medicine thinking, and DG's therapeutic effect in CHB was defined.PMID:35593360 | DOI:10.2174/1381612828666220421134910 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 20, 2022 Category: Drugs & Pharmacology Authors: Yibo Liu Wenfang Guo Minhui Li Source Type: research

Beta Blockers can mask not only Hypoglycemia, but also Hypotension
CONCLUSION: Beta blockers can cause hypotension, mask it, and make recovery more difficult. This is clinically important and deserves to be more investigated and probably to be stated as a warning.PMID:35593361 | DOI:10.2174/1381612828666220421135523 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 20, 2022 Category: Drugs & Pharmacology Authors: Goran Koracevic Sladjana Micic Milovan Stojanovic Radmila Velickovic Radovanovic Milan Pavlovic Pavlovic Tomislav Kostic Dragan Djordjevic Nebojsa Antonijevic Maja Koracevic Vesna Atanaskovic Sonja Dakic Source Type: research

Evolving era of "sponges": Nanosponges as a versatile nanocarrier for the effective skin delivery of drugs
CONCLUSION: Nanosponges have been identified as a potential drug delivery carriers into as well as across skin. Delivery of biologics such as vaccines, enzymes, peptides, proteins, and antibodies, is also gaining attention in the recent past.PMID:35585809 | DOI:10.2174/1381612828666220518090431 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Prashansha Mullick Aswathi R Hegde Divya Gopalan Abhijeet Pandey Krishnadas Nandakumar Sanyog Jain Gowthamarajan Kuppusamy Srinivas Mutalik Source Type: research

The anti-atherosclerotic effects of natural polysaccharides: from phenomena to the main mechanisms of action
Curr Pharm Des. 2022 May 18. doi: 10.2174/1381612828666220518095025. Online ahead of print.ABSTRACTPolysaccharides (PSs) of plant origin have a variety of biological activities, anti-atherosclerotic including, but their use in atherosclerosis therapy is hindered by insufficient knowledge on the cellular and molecular mechanisms of action. In this review, the influence of several natural PSs on the function of macrophages, viral activity, and macrophage cholesterol metabolism has been discussed considering the tight interplay between these aspects in the pathogenesis of atherosclerosis. The anti-atherosclerotic activities o...
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Vasily P Karagodin Volha I Summerhill Shaw-Fang Yet Alexander N Orekhov Source Type: research

Docosahexaenoic acid ester of phloridzin reduces inflammation and insulin resistance via AMPK
CONCLUSION: The effects of PZ-DHA on insulin resistance in C2C12 myotubes may be mediated by the LKB1-AMPK signaling pathway. Hence, PZ-DHA is a promising therapeutic agent for insulin resistance in type 2 diabetes.PMID:35585811 | DOI:10.2174/1381612828666220518102440 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Jingqing Chen Zhenlong Wu Jin Wang Xuemeng Si Rui Zhang Tianqi Sun Qiaoyan Dong Wenqing Wu Yefeng Qiu Source Type: research

Trends in pharmaceutical design of new psychoactive substances detected in oral fluid of drivers around a music festival in south-west France: comparison 2019/2017
CONCLUSION: these pharmaceutical design trends (2019 vs 2017) observed in a population of drivers around a music festival seem to reflect those that can be seen in more general populations in France, with probably a rise in the consumption of synthetic cannabinoids.PMID:35585812 | DOI:10.2174/1381612828666220517160545 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Alexandr Gish V éronique Dumestre-Toulet Camille Richeval Jean-Fran çois Wiart Florian Hakim Delphine Allorge Jean-Michel Gaulier Source Type: research

Evolving era of "sponges": Nanosponges as a versatile nanocarrier for the effective skin delivery of drugs
CONCLUSION: Nanosponges have been identified as a potential drug delivery carriers into as well as across skin. Delivery of biologics such as vaccines, enzymes, peptides, proteins, and antibodies, is also gaining attention in the recent past.PMID:35585809 | DOI:10.2174/1381612828666220518090431 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Prashansha Mullick Aswathi R Hegde Divya Gopalan Abhijeet Pandey Krishnadas Nandakumar Sanyog Jain Gowthamarajan Kuppusamy Srinivas Mutalik Source Type: research

The anti-atherosclerotic effects of natural polysaccharides: from phenomena to the main mechanisms of action
Curr Pharm Des. 2022 May 18. doi: 10.2174/1381612828666220518095025. Online ahead of print.ABSTRACTPolysaccharides (PSs) of plant origin have a variety of biological activities, anti-atherosclerotic including, but their use in atherosclerosis therapy is hindered by insufficient knowledge on the cellular and molecular mechanisms of action. In this review, the influence of several natural PSs on the function of macrophages, viral activity, and macrophage cholesterol metabolism has been discussed considering the tight interplay between these aspects in the pathogenesis of atherosclerosis. The anti-atherosclerotic activities o...
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Vasily P Karagodin Volha I Summerhill Shaw-Fang Yet Alexander N Orekhov Source Type: research

Docosahexaenoic acid ester of phloridzin reduces inflammation and insulin resistance via AMPK
CONCLUSION: The effects of PZ-DHA on insulin resistance in C2C12 myotubes may be mediated by the LKB1-AMPK signaling pathway. Hence, PZ-DHA is a promising therapeutic agent for insulin resistance in type 2 diabetes.PMID:35585811 | DOI:10.2174/1381612828666220518102440 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Jingqing Chen Zhenlong Wu Jin Wang Xuemeng Si Rui Zhang Tianqi Sun Qiaoyan Dong Wenqing Wu Yefeng Qiu Source Type: research

Trends in pharmaceutical design of new psychoactive substances detected in oral fluid of drivers around a music festival in south-west France: comparison 2019/2017
CONCLUSION: these pharmaceutical design trends (2019 vs 2017) observed in a population of drivers around a music festival seem to reflect those that can be seen in more general populations in France, with probably a rise in the consumption of synthetic cannabinoids.PMID:35585812 | DOI:10.2174/1381612828666220517160545 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 19, 2022 Category: Drugs & Pharmacology Authors: Alexandr Gish V éronique Dumestre-Toulet Camille Richeval Jean-Fran çois Wiart Florian Hakim Delphine Allorge Jean-Michel Gaulier Source Type: research

MEG8 :An Indispensable Long Non-coding RNA in Multiple Cancers
CONCLUSIONS: LncRNA MEG8 is expected to be a new therapeutic target or biomarker for a wide range of cancers in the future.PMID:35578848 | DOI:10.2174/1381612828666220516090245 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 17, 2022 Category: Drugs & Pharmacology Authors: Zhuoying Du Fangshun Tan Jinlan Chen Bei Wang Yuling Liu Fangnan Zhao Yinxin Wu Chengfu Yuan Source Type: research