Prediction Models and Scores in Adult Congenital Heart Disease.
Abstract Nowadays, most patients with congenital heart disease survive to adulthood, thanks to advances in pediatric cardiac surgery, but often present with various comorbidities and long-term complications, posing challenges in their management. The development and clinical use of risk scores for the prediction of morbidity and/or mortality in adults with congenital heart disease (ACHD) is fundamental in achieving optimal management for these patients, including appropriate follow-up frequency, treatment escalation and timely referral for invasive procedures or heart transplantation. In comparison with other fiel...
Source: Current Pharmaceutical Design - January 11, 2021 Category: Drugs & Pharmacology Authors: Arvanitaki A, Ntiloudi D, Giannakoulas G, Dimopoulos K Tags: Curr Pharm Des Source Type: research

The State of the Problem of Achieving Extremely Low LDL Levels.
Abstract Patients who have achieved very low low-density lipoprotein cholesterol (LDL-C) levels in clinical trials have the lowest cardio-vascular risk. The current clinical guidelines set such concentration for LDL-C as
Source: Current Pharmaceutical Design - January 11, 2021 Category: Drugs & Pharmacology Authors: Korneva V, Kuznetsova T, Julius U Tags: Curr Pharm Des Source Type: research

Focus on the Multimodal Role of Biomarkers in Breast Cancer.
Abstract Breast cancer is the most common type of malignancy affecting women worldwide and also being the mostly diagnosed one. Mammography being the gold standard for diagnosis but there are high chances that it can give false- negative as well false-positive test results. Finding cost-effective, readily available and increased sensitivity as well as specificity for diagnosis is the need right now to decrease the mortality as well as morbidity rate. Application of biomarkers to the clinical use has paved way for a better prognosis, diagnosis, detection, screening and better clinical results. The efficacy of the t...
Source: Current Pharmaceutical Design - January 11, 2021 Category: Drugs & Pharmacology Authors: Lang DK, Sood A, Kaur R, Arora R, Behl T Tags: Curr Pharm Des Source Type: research

COVID -19 infection: Epidemiology, Virology, Clinical Features, Diagnosis and Pharmacological Treatment.
Abstract Coronavirus was first discovered during the year 1930 and since then vrious coronaviruses like HKU1, MERS-CoV , NL63 and SARS-CoV-2 had been found to infect humans. The COVID-19 pandemic caused by SARS-CoV-2 is spreading at an alarming rate thereby created health emergency around the world. SARS-CoV2 is reportedly to be originated from wet animal market of Wuhan, China. Since then the world is searching for effective way to manage and treat the COVID-19 infection. The infections has already multiplied with several folds compared to the number of person infected by Middle East Respiratory Syndrome Coronavi...
Source: Current Pharmaceutical Design - January 11, 2021 Category: Drugs & Pharmacology Authors: Kaur A, Bhalla V, Salahuddin M, Rahman SO, Pottoo FH Tags: Curr Pharm Des Source Type: research

Natural Products, a Potential Therapeutic Modality in Management and Treatment of nCoV-19 Infection: Preclinical and Clinical based Evidence.
Abstract Recent outbreak of novel coronavirus (nCoV-19) has put an enormous burden on global public health. Millions of people were affected by this pandemic situation and as of now, no effective antiviral drug has been found for the management of this situation. Cytokine storm, acute respiratory distress, hypoxia and multi-organ failure are hallmark clinical conditions of this disease. Trials for several investigational and repurposed drugs are being conducted but none of them were found to be safe and effective. However, for the critically ill patient, plasma therapy, dexamethasone, and remdesivir are included i...
Source: Current Pharmaceutical Design - January 11, 2021 Category: Drugs & Pharmacology Authors: Iqubal A, Iqubal MK, Ahmed M, Haque SE Tags: Curr Pharm Des Source Type: research

Nutrition and NSCLC; Should We Administer Food Supplements?
is K Abstract Non-small cell lung cancer is usually diagnosed at advanced stage disease. We have novel diagnostic tools, however; prevention is still the best way to idetify this disease. Patients receive different treatments with different adverse effects. Targeted traetment with tyrosine kinase inhibitors, and immunotherapy have entered everyday clinical practice. The nutritional status of a patient plays a crucial role in the treatment of a patient. Cahexia is observed in most cancer patients and it has been identyfied as an independent factor to the overall survival of a patient. The improvement of nutritional...
Source: Current Pharmaceutical Design - January 11, 2021 Category: Drugs & Pharmacology Authors: Zarogoulidis P, Kosmidis C, Kesisoglou I, Tsakiridis K, Hohenforst-Schmidt W, Huang H, Romanidis Κ, Vagionas A, Sapalidis K Tags: Curr Pharm Des Source Type: research

In silico Prediction and Designing of Potential siRNAs to be Used as Antivirals Against SARS-CoV-2.
CONCLUSIONS: The siRNAs were predicted and selected based on their greater potency and specificity. The predicted siRNAs need to be validated experimentally for their effective binding and antiviral activity. PMID: 33430748 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 11, 2021 Category: Drugs & Pharmacology Authors: Sohrab SS, Aly El-Kafrawy S, Abbas AT, Bajrai LH, Azhar EI Tags: Curr Pharm Des Source Type: research

Asymmetric dimethylarginine: a key player in the pathophysiology of endothelial dysfunction, vascular inflammation and atherosclerosis in rheumatoid arthritis?
Abstract Patients with rheumatoid arthritis (RA), a chronic and disabling autoimmune condition that is characterized by articular and extra-articular manifestations and a pro-inflammatory and pro-oxidant state, suffer from premature atherosclerosis and excessive cardiovascular disease burden. A key step in the pathogenesis of atherosclerosis is the impaired synthesis of the endogenous messenger nitric oxide (NO) by endothelial cells which, in turn, alters local homeostatic mechanisms and favors vascular damage and plaque deposition. While the exact mechanisms of endothelial dysfunction in RA remain to be establish...
Source: Current Pharmaceutical Design - January 6, 2021 Category: Drugs & Pharmacology Authors: Mangoni AA, Tommasi S, Sotgia S, Zinellu A, Paliogiannis P, Piga M, Cauli A, Pintus G, Carru C, Erre GL Tags: Curr Pharm Des Source Type: research

Histone Demethylase KDM4A Inhibition Represses Neuroinflammation and Improves Functional Recovery in Ischemic Stroke.
CONCLUSION: The current results demonstrated KDM4A inhibition improves functional recovery in ischemic stroke by repressing NF-κB activation and subsequent neuroinflammation. PMID: 33402077 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 5, 2021 Category: Drugs & Pharmacology Authors: Liu Y, Zhao L, Zhang J, Lv L, Han K, Huang C, Xu Z Tags: Curr Pharm Des Source Type: research

Serum uric acid and diabetes: from pathophysiology to cardiovascular disease.
Abstract Hyperuricemia, has been traditionally related to nephrolithiasis and gout. However, it has also been associated with the development of type 2 diabetes mellitus (T2DM) and cardiometabolic and cardiovascular diseases. Pathophysiologically, elevated serum uric acid (SUA) levels may be associated with abnormal lipid and glucose metabolism. In this narrative review, we consider the associations between hyperuricemia, hyperglycemia, atherosclerosis and thrombosis. Furthermore, we comment on the available evidence linking elevated SUA levels with the incidence and outcomes of coronary heart disease, stroke, per...
Source: Current Pharmaceutical Design - January 4, 2021 Category: Drugs & Pharmacology Authors: Katsiki N, Dimitriadis GD, Mikhailidis DP Tags: Curr Pharm Des Source Type: research

Highlights on Medical Treatment of Uterine Fibroids.
Abstract Uterine fibroids (leiomyomas or myomas) are the most frequent benign tumors in women. Heavy menstrual bleeding with resultant anemia, dysmenorrhea, chronic pelvic pain, infertility urinary symptoms and constipation are generally associated with uterine fibroids (UFs). Although strategies mainly resort to surgical intervention, medical treatments are considered the first-line treatment to preserve fertility and avoid surgery. The aim of this review is to offer available and newest medical treatment options for symptomatic UFs. Various medical therapies are now available for women with uterine fibroids, alt...
Source: Current Pharmaceutical Design - January 1, 2021 Category: Drugs & Pharmacology Authors: Angioni S, D'Alterio MN, Daniilidis A Tags: Curr Pharm Des Source Type: research

Lipoxygenase (LOX) Pathway: A Promising Target to Combat Cancer.
Abstract Leukotrienes are one of the major eicosanoid lipid mediators being produced as a result of oxidative transformation of arachidonic acid. Subsequently, they get converted into various cellular signaling hormones by a series of enzymes of myeloid origin to mediateor debilitate inflammation. Interestingly, the available literature demonstrates the pivotal role of eicosanoids in neurodegenerative, obesity, diabetes, cardiovascular diseases and cancers as well. The aberrant metabolism of arachidonic acid by LOX pathway is a common feature of epithelial derived malignancies and suggests the contributory role of...
Source: Current Pharmaceutical Design - January 1, 2021 Category: Drugs & Pharmacology Authors: Vishnupriya P, Aparna A, Vijaya Padma V Tags: Curr Pharm Des Source Type: research

Inhaled Antifungal Agents for the Treatment and Prophylaxis of Pulmonary Mycoses.
Abstract Pulmonary mycoses are associated with high morbidity and mortality. The current standard treatment by systemic administration is limited by inadequate local bioavailability and systemic toxic effects. Aerosolisation of antifungals is an attractive approach to overcome these problems, but no inhaled antifungal formulation is currently available for the treatment of pulmonary mycoses. Hence, the development of respirable antifungals formulations is of interest and in high demand. In this review, the recent advances in the development of antifungal formulations for pulmonary delivery are discussed, including...
Source: Current Pharmaceutical Design - January 1, 2021 Category: Drugs & Pharmacology Authors: Liao Q, Lam KW Tags: Curr Pharm Des Source Type: research

Use of Natural Compounds as a potential therapeutic agent against COVID-19.
Abstract The current 2019-nCoV outbreak is becoming extremely noxious and has affected the whole world. Its control is challenging because there is no effective vaccine or drug available for Coronavirus disease. The Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), previously named as 2019 novel Coronavirus (2019-nCoV), primarily targets the human respiratory system to lung lesions and lethal pneumonia. Natural products have always shown a crucial role in the process of drug development against various diseases. They could be leads for further drug development to combat emergent mutants of the coronavi...
Source: Current Pharmaceutical Design - January 1, 2021 Category: Drugs & Pharmacology Authors: Wahab S, Ahmad I, Irfan S, Baig MH, Farouk AE, Dong JJ Tags: Curr Pharm Des Source Type: research

The pathogenic subpopulation of Th17 cells in obesity.
Abstract Obesity is a metabolic disease characterized by a chronic subclinical inflammatory response associated with an imbalance/dysregulation of cellular homeostasis in response to excessive nutrient intake and accumulation. CD4+ Tlymphocytes form different populations, Th1, Th2, Th9, Th17, Th22, and Treg cells, which have phenotypic and functional differences. Despite the active study of Th17 cells in severe disorders, their role in metabolic disorders, particularly in obesity, is not well understood. Th17 lymphocytes, depending on the microenvironment, can form pathogenic and nonpathogenic subpopulations. Syst...
Source: Current Pharmaceutical Design - January 1, 2021 Category: Drugs & Pharmacology Authors: Todosenko N, Vulf M, Yurova K, Skuratovskaia D, Khaziakhmatova O, Gazatova N, Melashchenko O, Urazova O, Litvinova L Tags: Curr Pharm Des Source Type: research

Routes to Reduce the Time and Failing in Drug Development.
PMID: 33357179 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 30, 2020 Category: Drugs & Pharmacology Authors: Basile L, Guccione S Tags: Curr Pharm Des Source Type: research

Application of Monte Carlo Algorithms to Cardiac Imaging Reconstruction.
Abstract Monte Carlo algorithms have a growing impact on nuclear medicine reconstruction processes. One of the main limitations of myocardial perfusion imaging (MPI) is the effective mitigation of the scattering component, which is particularly challenging in Single Photon Emission Computed Tomography (SPECT). In SPECT, no timing information can be retrieved to locate the primary source photons. Monte Carlo methods allow an event-by-event simulation of the scattering kinematics, which can be incorporated into a model of the imaging system response. This approach was adopted since the late Nineties by several autho...
Source: Current Pharmaceutical Design - December 28, 2020 Category: Drugs & Pharmacology Authors: Zhou J, Leja AG, Salvatori M, Latta DD, Di Fulvio A Tags: Curr Pharm Des Source Type: research

Dogs as a model for chemotherapy of Chagas disease and Leishmaniasis.
CONCLUSION: The benefits of treatment in terms of reducing or eliminating lesions and/or cardiac dysfunctions were demonstrated at acute and/or chronic phases relative to parasite load and/or the T. cruzi strain resistance to treatment. BZ presented better therapeutic results than the two EBI compounds evaluated. Although treatment of the canine visceral leishmaniasis was not able to induce complete parasite clearance, it can improve clinical recovery. Thus, the dog is a good model for CD and Leishmaniasis studies of chemotherapy and may be indicated for pre-clinical trials of new treatments. PMID: 33371843 [PubMed - ...
Source: Current Pharmaceutical Design - December 28, 2020 Category: Drugs & Pharmacology Authors: de Lana M, Giunchetti RC Tags: Curr Pharm Des Source Type: research

In silico studies reveal antiviral effects of traditional Indian spices on COVID-19.
CONCLUSION: Optimal use of traditional spices in our daily meals may help fight against COVID-19. This study also paves the path for herbal drug formulation against SARS-CoV-2 after wet lab validation. PMID: 33357192 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 22, 2020 Category: Drugs & Pharmacology Authors: Kumar B, Zaidi S, Haque S, Dasgupta N, Hussain A, Unni S, Singh V, Mishra BN Tags: Curr Pharm Des Source Type: research

3-MA Enhanced Chemosensitivity in Cisplatin Resistant Hypopharyngeal Squamous Carcinoma Cells via Inhibiting Beclin -1 Mediated Autophagy.
CONCLUSION: Our work confirmed that enhanced autophagy is an important cause of cisplatin resistance in FaDu cells. The use of 3-MA can significantly reduce autophagy level and arresting its cell cycle, promote apoptosis and reverse the cisplatin resistance condition, this effect is partly mediated by inhibition of Beclin-1 expression. Our data provides a theoretical basis for the application of 3-MA in overcoming cisplatin resistance in hypopharyngeal cancer. PMID: 33349212 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 21, 2020 Category: Drugs & Pharmacology Authors: Zhang J, Mao W, Liu Y, Ding J, Wang J, Yu Z, Huang R, Yang S, Sun Y, Dong P Tags: Curr Pharm Des Source Type: research

Hydrogen Gas Therapy: From Preclinical Studies to Clinical Trials.
CONCLUSION: H2 is an easily administered, inexpensive, and well-tolerated agent that is highly effective for a wide range of conditions in emergency medicine, as well as for preserving donated organs. PMID: 33349213 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 21, 2020 Category: Drugs & Pharmacology Authors: Sano M, Tamura T Tags: Curr Pharm Des Source Type: research

New Generation of Biocompatible Nanocarriers with Targeting Potential.
PMID: 33327902 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 19, 2020 Category: Drugs & Pharmacology Authors: Suresh PK, Saraf SA, Jain SK Tags: Curr Pharm Des Source Type: research

Viral Diseases and Natural Products: Prospects in COVID-19 Treatment (Part-I).
PMID: 33327907 [PubMed - in process] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 19, 2020 Category: Drugs & Pharmacology Authors: Kamal MA, Khan MA Tags: Curr Pharm Des Source Type: research

Flavonoids from marine-derived actinobacteria as anticancer drugs.
Abstract Flavonoids represent a large diverse group of natural products that are used as a traditional medicine against various infectious diseases. They possess many biological activities including antimicrobial, antioxidant, antiinflammatory, anti-cancer and anti-diabetic. Commercially Flavonoids are mainly obtained from plants, however, several challenges faced that production. Microorganisms have been known as natural sources of a wide range of bioactive compounds including flavonoids. Actinobacteria are the most prolific group of microorganisms for the production of bioactive secondary metabolites hold many a...
Source: Current Pharmaceutical Design - December 16, 2020 Category: Drugs & Pharmacology Authors: Hozzein WN, Mohany M, Alhawsawi SMM, Zaky MY, Al-Rejaie SS, Alkhalifah DHM Tags: Curr Pharm Des Source Type: research

Emergence and Reemergence of Human Coronaviruses: Spike Protein as the Potential Molecular Switch and Pharmaceutical Target.
CONCLUSIONS: High propensity of mutations and "molecular adaptations" in coronaviruses create the hot spots and high potential for "host switching" leading to emergence of more virulent strains human CoVs. The public/global health agencies, medical communities and research scientists should be prepared for emergence and reemergence of new human CoV strain(s) leading to potential disease outbreaks. The inhibitors binding with conserved druggable regions of spike proteins from multiple strains CoV may have utility as broad-spectrum antiviral drugs to combat future emergence of CoVs. PMID: 33327904 [P...
Source: Current Pharmaceutical Design - December 15, 2020 Category: Drugs & Pharmacology Authors: Ahmad F, Kamal MA, Tekwani BL Tags: Curr Pharm Des Source Type: research

Significance of Hemodynamics Biomarkers, Tissue Biomechanics and Numerical Simulations in the Pathogenesis of Ascending Thoracic Aortic Aneurysms.
Abstract Guidelines for the treatment of aortic wall diseases are based on measurements of maximum aortic diameter. However aortic rupture or dissections do occur for small aortic diameters. Growing scientific evidence underlines the importance of biomechanics and hemodynamics in aortic disease development and progression. Wall shear stress (WWS) is an important hemodynamics marker which depends on aortic wall morphology and on the aortic valve function. WSS could be helpful to interpret aortic wall remodeling and define personalized risk criteria. The complementarity of Computational Fluid Dynamics and 4D Magneti...
Source: Current Pharmaceutical Design - December 14, 2020 Category: Drugs & Pharmacology Authors: Campisi S, Jayendiran R, Condemi F, Viallon M, Croisille P, Stephane A Tags: Curr Pharm Des Source Type: research

An Overview of Natural and Synthetic Analogs of Quinoline for the Prophylaxis of COVID-19. Chloroquine Analogs: An Overview of Natural and Synthetic Quinolines as Broad Spectrum Antiviral Agents.
In this study, we review Chloroquine and its synthetic and natural analogs for their antiviral properties in a variety of different viruses. Furthermore, we review the compound's potential abilities to attenuate symptoms associated with viral infections. Natural compounds that share scaffolding to Chloroquine can act as antivirals or attenuate symptoms through stimulate the host immune system or reducing oxidative stress. Furthermore, we discuss perspectives of the drug's repurposing due to its ability to inhibit beta-hematin formation and to be a Zinc Ionophore. PMID: 33308117 [PubMed - as supplied by publisher] (Sou...
Source: Current Pharmaceutical Design - December 11, 2020 Category: Drugs & Pharmacology Authors: Pallaval VB, Kanithi M, Meenakshisundaram S, Jagadeesh A, Alavala M, Pillaiyar T, Manickam M, Chidipi B Tags: Curr Pharm Des Source Type: research

Effects of an Integrative Mind-body-medicine Group Program for Breast Cancer Patients during Chemotherapy: An Observational Study.
CONCLUSION: Breast cancer patients benefit from an integrative mind-body-medicine group program during chemotherapy regarding the quality of life and psychological symptoms. Randomized controlled trials are warranted. PMID: 33308110 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Haller H, Choi KE, Lange S, Kümmel S, Paul A, Cramer H, Dobos G, Voiss P Tags: Curr Pharm Des Source Type: research

Histone Deacetylase Inhibitors and Papillary Thyroid Cancer.
CONCLUSION: HDACIs have no significant effect as monotherapy against PTC but further research needs to be conducted in order to investigate their potential effect when used as an additional modality. PMID: 33308111 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Spartalis E, Kotrotsios K, Chrysikos D, Spartalis M, Paschou SA, Schizas D, Tsamakis K, Dimitroulis D, Troupis T, Nikiteas N Tags: Curr Pharm Des Source Type: research

Mechanisms Underlying the Biological Effects of Molecular Hydrogen.
Abstract Aberrant redox-sensitive reactions and accumulation of oxidative damage can impair body functions and contribute to the development of various pathologies and aging. Although antioxidant substances have long been recognized as a measure of alleviating oxidative stress and restoring redox balance, the arsenal of effective means of preventing the development of various disorders is still limited. There is an emerging field that utilizes molecular hydrogen (H2 ) as a scavenger of free radicals and reactive oxygen species (ROS). Among the remarkable characteristics of H2 is its ability to counteract harmful e...
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Radyuk SN Tags: Curr Pharm Des Source Type: research

New approaches for hydrogen therapy of various diseases.
Abstract Hydrogen therapy has recently attracted increasing attention as an emerging and promising therapeutic technology due to its selective antioxidant properties and regulatory capacities in vivo. To effectively solve the low solubility issue of hydrogen, a variety of nanomaterials and devices for hydrogen supply have recently been developed, aiming to increase the concentration of hydrogen in specific disease location and realize controlled hydrogen release and combined treatment. In this review, we mainly focus on the latest advances in using hydrogen-generating devices and nanomaterials for hydrogen therapy...
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Zhang L, Yu H, Tu Q, He Q, Huang N Tags: Curr Pharm Des Source Type: research

Advances in Microbiome Detection Technologies and Application in Antirheumatic Drug Design.
Abstract Rheumatic diseases are a kind of chronic inflammatory and autoimmune disease affecting the connection or supporting structures of the human body, such as the most common diseases Ankylosing spondylitis (AS), gout and Systemic lupus erythematosus (SLE). Although the precise etiology and pathogenesis of the different types of rheumatic diseases remain mostly unknown, it is now commonly believed that these diseases are attributed to some complex interactions between genetics and environmental factors, especially the gut microbiome. Altered microbiome showed clinical improvement in disease symptoms and partia...
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Wu X, Chen X, Lyu X, Zheng H Tags: Curr Pharm Des Source Type: research

Trypanothione metabolism as Drug Target for Trypanosomatids.
llo C Abstract Chagas Disease, African sleeping sickness, and leishmaniasis are neglected diseases caused by pathogenic trypanosomatid parasites, which have a considerable impact on morbidity and mortality in poor countries. The available drugs used as treatment have high toxicity, limited access, and can cause parasite drug resistance. Long-term treatments, added to their high toxicity, result in patients that give up therapy. Trypanosomatids presents a unique trypanothione based redox system, which is the main responsible for maintaining the redox balance. Therefore, inhibition of these essential and exclusive p...
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Piñeyro MD, Arias DG, Parodi-Talice A, Guerrero SA, Robello C Tags: Curr Pharm Des Source Type: research

Exosome Limitations in the Treatment of Inflammatory Diseases.
CONCLUSION: Exosomes obtained from sick patients carry markers characteristic of the corresponding disease. Such exosomes can have pro-inflammatory, pro-fibrotic, cytotoxic, and oncogenic properties, and disrupt cellular cooperation. Until now, questions regarding the dose, reactions to repeated administration, and dosage regimes have not been completely resolved. PMID: 33302851 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Skuratovskaia D, Vulf M, Khaziakhmatova O, Malashchenko V, Komar A, Shunkin E, Gazatova N, Litvinova L Tags: Curr Pharm Des Source Type: research

Natural Products Homoharringtonine and Emetine Alkaloids for SARSCoV-2 Treatment Options.
CONCLUSION: This review specifically focuses on the recent findings of these alkaloids against coronaviruses and possible treatment options for SARS-CoV-2. It is expected that natural products as alkaloids from herbal plants could be considered as novel and valuable candidates for the new antiviral drugs against SARS-CoV-2. PMID: 33302852 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Sohrab SS, Suhail M, Kamal MA, Azhar EI Tags: Curr Pharm Des Source Type: research

Silybin B and Cianidanol Inhibit M pro and Spike Protein of SARS-CoV-2: Evidence from in Silico Molecular Docking Studies.
CONCLUSION: Silybin B and Cianidanol showed excellent binding and ADME properties compared with the currently endeavored drugs and can be exploited as therapeutic options against SARS-CoV-2 infection after experimental validation and clinical trials. PMID: 33302853 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Srivastava R, Tripathi S, Unni S, Hussain A, Haque S, Dasgupta N, Singh V, Mishra BN Tags: Curr Pharm Des Source Type: research

The Novel Antipsychotic Drug Cariprazine and Cognition Enhancing Drugs: Indications for Their Use as an Add-on Therapy in Schizophrenia.
CONCLUSION: In clinical trials, patients with treatment-resistant forms of psychosis should be examined to know whether a combination therapy with clozapine and a novel antipsychotic drug can ameliorate the PANSS total score. In schizophrenia, long-acting injectable antipsychotic drugs are a safe and tolerable maintenance therapy. In further clinical studies, it should be investigated whether patients with treatment-resistant forms of psychoses can improve negative schizophrenic symptoms and cognitive functions by an add-on therapy with cognition enhancing drugs. PMID: 33302854 [PubMed - as supplied by publisher] (Sou...
Source: Current Pharmaceutical Design - December 10, 2020 Category: Drugs & Pharmacology Authors: Werner FM, Coveñas R Tags: Curr Pharm Des Source Type: research

Risk Models and Scores of Cardiovascular Disease in Patients with Diabetes Mellitus.
Abstract Diabetes mellitus (DM) is an established risk factor for atherosclerotic cardiovascular disease (CVD) and patients with DM are at a two to four-fold higher cardiovascular risk, including myocardial infraction, unstable angina, stroke, and heart failure. All of the above have arisen interest in CVD preventive strategies by the use of non-invasive methods, such as risk scores. The most common approach is to consider DM as a CVD equivalent and, therefore, to treat patients with DM in a similar way to those who required secondary CVD prevention. However, this approach has been disputed as all patients with DM...
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Kostopoulos G, Antza C, Doundoulakis I, Toulis KA Tags: Curr Pharm Des Source Type: research

Comparative Analysis of Risk Stratification Scores in Atrial Fibrillation.
CONCLUSION: Further work is warranted to analyze new reliable risk stratification schemes and optimally implement them into routine clinical life. PMID: 33302847 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Athanasios S, Ioannis D, Christina A, Stefanos Z, Ioannis F, Apostolos T Tags: Curr Pharm Des Source Type: research

Pregnancy and Viral Hepatitis: Current Concepts.
Abstract Viral hepatitis in pregnancy constitutes a complex issue, requiring meticulous management due to the potential potent compromise of both mother's and fetus' health. Hepatitis B and C are implicated with a high risk for chronicity, whereas hepatitis A and hepatitis E have an acute course. In pre-existing viral disease, pregnancy may lead to exacerbation of the disease's course due to a plethora of hormonal, immunological and genetic alterations. Vice versa, viral hepatitis, acute or chronic, during pregnancy, can cause gestational complications that may lead to significant maternal and neonatal morbidity a...
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Tagkou NM, Kondylis G, Cholongitas E Tags: Curr Pharm Des Source Type: research

Yb/chitosan catalyzed synthesis of highly substituted piperidine derivatives for potential nuclease activity and DNA binding study.
CONCLUSION: Hence, it could be suggested that compounds bearing spiro-piperidine scaffold synthesized using reusable nano-catalyst would be an effective biological agent. PMID: 33302849 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Laskar K, Farhan M, Ahmad A Tags: Curr Pharm Des Source Type: research

Phospholipid Analogues as Chemotherapeutic Agents Against Trypanoso matids.
CONCLUSION: Phospholipid analogues are already known for their antiprotozoal activity. Several studies have been conducted in order to synthesize novel derivatives with the aim to improve current treatments such as miltefosine, with promising results. Photolabeling and fluorescent alkyl phospholipid analogues have contributed to the clarification of the mode of action of this drug family. PMID: 33302850 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Chazapi E, Magoulas GE, Prousis KC, Calogeropoulou T Tags: Curr Pharm Des Source Type: research

Anti-malarial Drugs are Not Created Equal for SARS-CoV-2 Treatment: A Computational Analysis Evidence.
CONCLUSION: Our data suggest that hydroxychloroquine may exert additional direct antiviral activity compared to chloroquine. In the absence of clinical studies comparing the efficacy of these two compounds, hydroxychloroquine may offer additional effects and may be considered as first choice. PMID: 33302855 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Ronsisvalle S, Panarello F, Di Mauro R, Bernardini R, Volti GL, Cantarella G Tags: Curr Pharm Des Source Type: research

Quorum Sensing - A Stratagem for Conquering Multi-Drug Resistant Pathogens.
Abstract Quorum sensing is defined as cell to cell communication between microorganisms, which enables microorganisms to behave as multicellular organisms. Quorum sensing enables many collaborative benefits such as synchronisation of virulence factors and biofilm formation. Both quorum sensing as well as biofilm formation encourage the development of drug resistance in microorganisms. Biofilm formation and quorum sensing are causally linked to each other and play role in the pathogenesis of microorganisms. With the increasing drug resistance against the available antibiotics and antifungal medications, scientists ...
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Tonkin M, Khan S, Wani MY, Ahmad A Tags: Curr Pharm Des Source Type: research

Fagonia indica; A Review on Chemical Constituents, Traditional Uses and Pharmacological Activities.
This article is a review based on different studies regarding occurrence, phytochemistry, traditional uses, biochemical constituents and therapeutic uses of F. indica. Available literature review provided base for this review. The presence of flavonoids, saponins, tannins, glycosides, pectin and alkaloids were confirmed by different researchers. F. indica is very important medicinal plant because it has different therapeutic and traditional uses such as antidiabetic, anticancer, antileshminial, antipyretic, antiinflammatory, laxative, gastroprotective, hepatoprotective and antioxidant effects. Further in vitro and in vivo ...
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Ali K, Khan H Tags: Curr Pharm Des Source Type: research

Myocardial Infarction in Systemic Lupus Erythematosus - the Sex Specific Risk Profile.
CONCLUSION: Systemic lupus erythematosus is a major contributor to atherosclerotic and non-atherosclerotic mechanisms involved in the development of myocardial infarction, which should be taken into account during therapeutic treatment. Although Systemic lupus erythematosus per se is a "female" disease, males are at increased cardiovascular risk and worse outcome. PMID: 33302858 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Vavlukis M, Pop-Gjorceva D, Poposka L, Sandevska E, Kedev S Tags: Curr Pharm Des Source Type: research

Elucidating the Biological Activity of Fish-Derived Collagen and Gelatine Hydrolysates using Animal Cell Culture-A review.
Abstract A large percentage of a fish's weight is generally discarded during fish processing. Reducing waste in products of marine origin is a subject of great interest within the scientific community. Pelagic by-products such as the structural protein collagen, which can be generated during the processing of fish, has been proposed as an alternative to terrestrial, mammalian sources due to advantages including high availability and low risk of zoonotic disease transmission. Gelatine has multiple possible applications, ranging from nutraceutical applications to cosmetics and has the advantage of being generally re...
Source: Current Pharmaceutical Design - December 9, 2020 Category: Drugs & Pharmacology Authors: Magtaan JK, Fitzpatrick B, Murphy R, Hayes M Tags: Curr Pharm Des Source Type: research

Hydrogen Commonly Applicable to Medicine to Agriculture: From Molecular Mechanisms to the Field.
Abstract The emerging field of hydrogen biology has to date mainly been applied in medicine. However, hydrogen biology can also enable positive outcomes in agriculture. Agriculture faces significant challenges resulting from a growing population, climate change, natural disasters, environment pollution, and food safety issues. In fact, hydrogen agriculture is a practical application of hydrogen biology, which may assist in addressing many of these challenges. It has been demonstrated that hydrogen gas (H2) may enhance plant tolerance towards abiotic and biotic stresses, regulate plant growth and development, incre...
Source: Current Pharmaceutical Design - December 7, 2020 Category: Drugs & Pharmacology Authors: Li L, Lou W, Kong L, Shen W Tags: Curr Pharm Des Source Type: research

Impact of Guidelines on Hypertension Control in the Elderly.
Abstract BACKGROUND: Hypertension control is a crucial measure to reduce cardiovascular (CV) risk, and blood pressure (BP) treatment targets have been recently revised to address this issue. However, achieving the recommended goal may be challenging. OBJECTIVE: We aimed to assess the prevalence of uncontrolled hypertension according to the US hypertension guidelines among elderly participants in an Italian nationwide epidemiological survey, the relevant clinical correlates, and the agreement with the application of the European guidelines. METHODS: Elderly (≥65y) volunteers enrolled in an Italian nati...
Source: Current Pharmaceutical Design - December 7, 2020 Category: Drugs & Pharmacology Authors: Pinto RD, Dobre M, Pagliacci S, Ferri C Tags: Curr Pharm Des Source Type: research

The Impact of Immune Cell-derived Exosomes on Immune Response Initiation and Immune System Function.
Abstract Exosomes are small extracellular vesicles that pass genetic material between various cells to modulate or alter their biological function. The role of exosomes is to communicate with the target cell for cell-to-cell communication. Their inherent characteristics of exosomes, such as adhesion molecules, allow targeting specifically to the receiving cell. Exosomes are involved in cell to cell communication in the immune system including antigen presentation, natural killer cells (NK cells) and T cell activation/polarisation, immune suppression and various anti-inflammatory processes. In this review, we have ...
Source: Current Pharmaceutical Design - December 7, 2020 Category: Drugs & Pharmacology Authors: Tavasolian F, Hosseini AZ, Rashidi M, Soudi S, Abdollahi E, Momtazi-Borojeni AA, Sathyapalan T, Sahebkar A Tags: Curr Pharm Des Source Type: research