Hyperuricemia and Cardiovascular Disease.
Abstract Purine metabolism in the circulatory system yields uric acid as its final oxidation product, which is believed to be linked to the development of gout and kidney stones. Hyperuricemia is closely correlated with cardiovascular disease, metabolic syndrome, and chronic kidney disease, as attested by epidemiological and empirical research. In this review, we summarize the recent knowledge about hyperuricemia, with a special focus on its physiology, epidemiology, and correlation with cardiovascular disease. This review also discusses the possible positive effects of treatment to reduce urate levels in patients...
Source: Current Pharmaceutical Design - April 8, 2019 Category: Drugs & Pharmacology Authors: Zhang S, Wang Y, Cheng J, Huangfu N, Zhao R, Xu Z, Zhang F, Zheng W, Zhang D Tags: Curr Pharm Des Source Type: research

JAK inhibition: the most promising agents in the IBD pipeline?
és J Abstract Under current therapeutic algorithms, half of the patients with moderate-severe ulcerative colitis or Crohn's disease fail in achieving a sustained remission. New drugs with different mechanisms of action are needed. After two decades of new drug avenues in inflammatory bowel disease dominated by the development of monoclonal antibodies, in recent years we are witnessing promising developments of small molecules for these conditions. Their intrinsic characteristics make them attractive compared to monoclonal antibodies based on their oral administration, short plasma half-life, lack of immunog...
Source: Current Pharmaceutical Design - April 5, 2019 Category: Drugs & Pharmacology Authors: Fernández-Clotet A, Castro-Poceiro J, Panés J Tags: Curr Pharm Des Source Type: research

Inhibitors of DNA methylation and histone deacetylation as epigenetically active drugs for anticancer therapy.
Abstract Gene expression is regulated and tightly controlled by epigenetic mechanisms. Alterations of these mechanisms are frequently observed in various diseases, in particular, in various types of cancer. Malignant transformation is caused by the impairment of the mechanisms of cell differentiation and cell cycle control associated with epigenetic changes. Altered patterns of epigenetic modification associated with malignancies can potentially be reversed by some agents that act on the key proteins responsible for DNA/histone modification and chromatin remodelling. Examples of such substances include the inhibit...
Source: Current Pharmaceutical Design - April 5, 2019 Category: Drugs & Pharmacology Authors: Myasoedova VA, Grechko AV, Zhang D, Orekhov AN Tags: Curr Pharm Des Source Type: research

Human Placental Vascular Reactivity in Health and Disease: Implications for the Treatment of Pre-eclampsia.
CONCLUSIONS: This approach highlights the different pathways that are involved in the vascular regulation of the human placenta, changes that occur during PE and the importance of focusing on restoring these dysfunctional systems when studying treatment strategies for PE. PMID: 30950346 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 5, 2019 Category: Drugs & Pharmacology Authors: Hitzerd E, Broekhuizen M, Neuman RI, Colafella KMM, Merkus D, Schoenmakers S, Simons SHP, Reiss IKM, Danser AHJ Tags: Curr Pharm Des Source Type: research

Limitations and Opportunities in Topical Drug Delivery: Interaction between Silica Nanoparticles and Skin Barrier.
Abstract The first limiting barrier for the transport in the skin is the stratum corneum; different strategies have been developed to overcome this barrier, including chemical enhancers. However, these penetration enhancers have limitations, including toxic adverse effects. In this context, research into nanomaterials has provided new tools to increase the residence time of drugs by generating a reservoir, increasing the specificity of drugs and reducing their adverse effects, and improving the penetration of drugs that are difficult to formulate. Silica nanoparticles have been proposed as suitable nanocarriers fo...
Source: Current Pharmaceutical Design - April 4, 2019 Category: Drugs & Pharmacology Authors: Arriagada F, Morales J Tags: Curr Pharm Des Source Type: research

The regulation roles of Long Non-Coding RNA in the Chemoresistance Process of Ovarian cancer.
CONCLUSIONS: With the development of the study on drug resistance of ovarian cancer, the role of LncRNAs as sensitive biomarker and therapeutic target has emerged. And provides a direction for precision medicine of ovarian cancer resistance. PMID: 30947657 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 4, 2019 Category: Drugs & Pharmacology Authors: Qu J, Kamal MA, Yuan C Tags: Curr Pharm Des Source Type: research

Design of Sphingosine Kinases Inhibitors: Challenges and Recent Developments.
CONCLUSION: SphK1 and SphK2 have many common features but different and even opposite biological functions. For this reason several research groups are interested in understanding the therapeutic usefulness of a selective or non-selective inhibition of SphKs. Moreover a compensatory mechanism for the two isoforms has been demonstrated thus leading the development of dual inhibitors. PMID: 30947653 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 3, 2019 Category: Drugs & Pharmacology Authors: Magli E, Corvino A, Fiorino F, Frecentese F, Perissutti E, Saccone I, Santagada V, Caliendo G, Severino B Tags: Curr Pharm Des Source Type: research

Laponite-based nanomaterials for biomedical applications: A review.
Abstract Laponite based nanomaterials (LBNMs) are highly diverse regarding their mechanical, chemical, and structural properties, coupled with shape, size, mass, biodegradability and biocompatibility. These ubiquitous properties of LBNMs make them an appropriate material for extensive applications. These have enormous potential for effective and targeted drug delivery comprised of numerous biodegradable materials which results into enhanced bioavailability. Moreover, the clay material has been explored in tissue engineering and bioimaging for diagnosis and treatment of various diseases. The material has been profo...
Source: Current Pharmaceutical Design - April 2, 2019 Category: Drugs & Pharmacology Authors: Das SS, Neelam, Hussain K, Singh S, Hussain A, Faruk A, Mike T Tags: Curr Pharm Des Source Type: research

Ethnobotany, phytochemistry and traditional uses of Curcuma spp. and pharmacological profile of two important species (C. longa and C. zedoaria): a review.
CONCLUSIONS: In this study, we reviewed various studies conducted on ethno-medicinal, ITM properties and photochemistry of Curcuma spp. Also pharmacological activities of two species, C. longa and C. zedoaria are summarized. Pre-clinical investigations have demonstrated some of the traditional aspects of Curcuma such as wound healing, anti-arthritic, anti-tumor and liver protective activities. These could be related to antioxidant and anti-inflammatory properties of Curcuma which might be due to high amounts of phenolic compounds. Curcuma is mentioned to have neural tonic properties in ITM which has been confirmed by some ...
Source: Current Pharmaceutical Design - April 2, 2019 Category: Drugs & Pharmacology Authors: Ayati Z, Ramezani M, Amiri MS, Moghadam AT, Rahimi H, Abdollahzade A, Emami SA, Sahebkar A Tags: Curr Pharm Des Source Type: research

Depression and treatment with effective herbs.
In this study, depression as well as the factors and mechanisms involved in its development are first addressed, and then medicinal plants effective in the treatment of depression along with their mechanisms of actions are reported. PMID: 30947651 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 1, 2019 Category: Drugs & Pharmacology Authors: Fathinezhad Z, Sewell RDE, Lorigooini Z, Rafieian-Kopaei M Tags: Curr Pharm Des Source Type: research

GDF-15 is a multifunctional modulator and potential therapeutic target in cancer.
Abstract Various pathological processes are associated with the aberrant expression and function of cytokines, especially those belonging to the transforming growth factor-β (TGF-β) family. Nevertheless, the functions of members of the TGF-β family in cancer progression and therapy are still uncertain. Growth differentiation factor- 15, which exists in intracellular and extracellular forms, is classified as a divergent member of the TGF-β superfamily. It has been indicated that GDF-15 is also connected to the evolution of cancer both positively and negatively depending upon the cellular state a...
Source: Current Pharmaceutical Design - April 1, 2019 Category: Drugs & Pharmacology Authors: Fang L, Li F, Gu C Tags: Curr Pharm Des Source Type: research

Creation Of Cultures Containing Mutations Linked With Cardiovascular Diseases Using Transfection And Genome Editing.
CONCLUSIONS: The most promising methods for creation of cell cultures containing mutations linked with cardiovascular diseases, were system CRISPR/Cas9 and the gene gun. PMID: 30931844 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Sazonova MA, Ryzhkova AI, Sinyov VV, Sazonova MD, Khasanova ZB, Nikitina NA Tags: Curr Pharm Des Source Type: research

Visit-to-visit blood pressure variability and arterial stiffness: Which came first: the chicken or the egg?
This article summarizes the recent literature on these topics. In the elderly hypertensives, strict BP control using CCBs would play a pivotal role to suppress arterial stiffening via VVV reduction. PMID: 30931845 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Miyauchi S, Nagai M, Dote K, Kato M, Oda N, Kunita E, Kagawa E, Yamane A, Higashihara T, Takeuchi A, Tsuchiya A, Takahari K Tags: Curr Pharm Des Source Type: research

Recent advances in knowledge of natural-derived bioactive as modulating agents of the renin-angiotensin-aldosterone system: therapeutic benefit in cardiovascular diseases.
CONCLUSION: While there are a number of evidence about the positive actions of different classes of secondary metabolites for the treatment of cardiovascular and renal diseases, are scarce the clinical assays established to demonstrate their value in humans. PMID: 30931846 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: de Souza P, da Silva LM, de Andrade SF, Gasparotto A Tags: Curr Pharm Des Source Type: research

The Low Molecular Weight Brain Derived Neurotrophic Factor Mimetics With Antidepressant-Like Activity.
Abstract The search for new highly-effective, fast-acting antidepressant drugs is extremely relevant. Brain derived neurotrophic factor (BDNF) and signaling through its tropomyosin-related tyrosine kinase B (TrkB) receptor, represents one of the most promising therapeutic targets for treating depression. BDNF is a key regulator of neuroplasticity in the hippocampus and the prefrontal cortex, the dysfunction of which is considered to be the main pathophysiological hallmark of this disorder. BDNF itself has no favorable drug-like properties due to poor pharmacokinetics and possible adverse effects. The design of sma...
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Gudasheva TA, Povarnina P, Tarasiuk AV, Seredenin SB Tags: Curr Pharm Des Source Type: research

Phytochemistry, Pharmacological Activities, Toxicity and Clinical Application of Momordica cochinchinensis.
Abstract Momordica cochinchinensis (Lour.) Spreng (M. cochinchinensis) is a deciduous vine that grows in Southeast Asia. It is known as gac in Vietnam and as Red Melon in English. Gac is reputed to be extremely benefited for health, and has been widely used as food and folk medicine in Southeast Asia. In China, the seed of M. cochinchinensis (Chinese name: Mu biezi) is used as traditional Chinese medicine (TCM) for the treatment of various diseases. There are more than 60 chemical constituents have been isolated from M. cochinchinensis. Modern pharmacology studies and clinical practice demonstrate that some chemic...
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Lan HY, Zhao B, Shen YL, Li XQ, Wang SJ, Zhang LJ, Zhang H Tags: Curr Pharm Des Source Type: research

The significance of heat shock protein 70 kDa in the development of acute focal myocardial and cerebral ischemia.
Abstract In acute focal ischemia of the heart and brain similar processes are developing despite the obvious differences in the structure, function, and blood supply of these organs. This review presents a contemporary view of involvement of heat shock proteins (HSPs) in the process of ischemic injury of the heart and brain and summarizes new clinical studies related to the role of HSP70 in patients with atherosclerosis. The main types of these proteins, their receptors, mechanisms of their functioning and the sources of circulating HSP70 are described. We also discuss the possible reasons of similarity of the eff...
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Konstantinova EV, Chipigina NS, Shurdumova MH, Kovalenko EI, Sapozhnikov AM Tags: Curr Pharm Des Source Type: research

Safety and Efficacy of Tocolytics for the Treatment of Spontaneous Preterm Labour.
CONCLUSION: The perfect tocolytic that is uniformly effective and safe does not exist. Cost, licensing and informed consent are considerations involved in choice. Efforts continue to develop and introduce other or better agents, including novel compounds such as progesterone, PGF2α antagonists and statins. PMID: 30931850 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Lamont RF, Jørgensen JS Tags: Curr Pharm Des Source Type: research

Methotrexate Disposition in Pediatric Patients with Acute Lymphoblastic Leukemia: What We Have Learned On the Genetic Variants of Drug Transporters.
CONCLUSION: Overall, the data critically reviewed in this mini-review article confirmed that polymorphisms in the genes encoding SLC and ABC transporters confer higher sensitivity to altered plasma levels, MTX-induced toxicity, and therapeutic response in pediatric patients with ALL. Pre-emptive determination may be helpful in individualizing treatment. PMID: 30931851 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Hu YH, Zhou L, Wang SS, Jing X, Guo HL, Sun F, Zhang Y, Chen F, Xu J, Ji X Tags: Curr Pharm Des Source Type: research

A review of the most important medicinal plants effective on cardiac ischemia-reperfusion injury.
CONCLUSION: Medicinal plants presented in this article seem to be able to prevent cardiac damage and the disease progression via affecting the factors that are effective on ischemia. PMID: 30931852 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Sedighi M, Sewell RDE, Nazari A, Abbaszadeh S, Amini A, Heydari Z, Rafieian-Kopaei M Tags: Curr Pharm Des Source Type: research

Valproic Acid and the Liver Injury in Patients with Epilepsy: An update.
CONCLUSION: Therapeutic drug monitoring (TDM) and routine liver biochemistry monitoring during VPA-therapy, as well as genotype screening for certain patients before VPA administration, could improve the safety profile of this antiepileptic drug. PMID: 30931853 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Guo HL, Jing X, Sun JY, Hu YH, Xu ZJ, Nie MM, Chen F, Lu XP, Qiu JC, Wang T Tags: Curr Pharm Des Source Type: research

Evaluation and exploitation of bioactive compounds of walnut, Juglans regia.
Abstract In the last few years, a great importance has been given to natural materials (such as walnuts, peanuts, chestnuts) due to their medicinal and pharmaceutical uses induced by the presence of natural agents, including polyphenols. Juglans regia is a traditional plant that has been used since ancient times in traditional medicine for the treatment of various diseases like microbial infections, stomach ache, thyroid dysfunctions, cancer, heart diseases and sinusitis. Recently, scientific attention for phytochemical profile of walnut by-products is increasing due to their valuable active constituents. Natural ...
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Croitoru A, Ficai D, Craciun L, Ficai A, Andronescu E Tags: Curr Pharm Des Source Type: research

A novel DKL [LKlLKlLlkKLLkLL-NH2; K is Lys, L is Leu, k is D-Lys, l is D-Leu] modified probe for positron emission tomography imaging.
Abstract Peptides containing the asparagine-glycine-arginine (NGR) motif can target the tumor neovascular biomarker CD13/aminopeptidase N receptor. D-K6L9 is a tumor-selective anti-cancer peptide. To improve the capacity of NGR peptides to target tumors, we joined the NGR and D-K6L9 peptides to form NKL. Next, we linked 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) to NKL and labeled it with gallium 68 (68Ga, t1/2 = 67.7 min) to form 68Ga-DOTA-NKL. This novel probe was characterized in vitro. 68Ga-DOTA-NKL was stable in phosphate buffered saline at room temperature and in human serum at 37°C....
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Liu Y, Li X, Gao Y, Kang F, Ma X, Yang W, Wang J, Ma W Tags: Curr Pharm Des Source Type: research

Cellular and molecular basis of osteoblastic and vascular niches in the processes of hematopoiesis and bone remodeling (A short review of modern views).
Abstract In evolutionary processes, human bone marrow has formed as an organ depot of various types of cells that arise from hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs). Vital HSC activity is controlled through molecular interactions with the niche microenvironment. The review describes current views on the formation of key molecular and cellular components of the HSC niche, which ensure maintenance of homeostasis in stem cell niches, obtained from studies of their role in regulating the proliferation and differentiation of HSCs, including the physiological, reparative and pathological remode...
Source: Current Pharmaceutical Design - March 29, 2019 Category: Drugs & Pharmacology Authors: Yurova KA, Khaziakhmatova OG, Melashchenko ES, Malashchenko VV, Shunki EO, Shupletsova VV, Ivanov PA, Khlusov IA, Litvinova LS Tags: Curr Pharm Des Source Type: research

Collaboration in Regulatory Science to Facilitate Therapeutic Development for Pregnant Women.
CONCLUSION: Collaborative efforts from all stakeholders, including industry, academia, advocacy groups, regulators, and other governmental agencies, if successful will increase the information needed to help make decisions regarding use of drugs during pregnancy and lactation. PMID: 30919771 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2019 Category: Drugs & Pharmacology Authors: Roca C, Sahin L, Yao L Tags: Curr Pharm Des Source Type: research

Long Noncoding RNAs as Diagnostic and Therapeutic Targets for Ischemic Stroke.
Abstract LncRNAs (long non-coding RNAs) are endogenous molecules lacking protein-encoding capacity, which have been identified as key regulators of ischemic stroke. Increasing evidence suggests that lncRNAs play critical roles in several aspects of ischemic stroke, including atherosclerosis, dyslipidemia, hypertension, and diabetes mellitus. Hence, lncRNAs may further broaden our understanding of stroke pathogenesis. Altered lncRNA expression has been found in rodent focal cerebral ischemia models and oxygen-glucose deprived mouse brain microvascular endothelial cells as well as stroke patients. LncRNAs are consid...
Source: Current Pharmaceutical Design - March 27, 2019 Category: Drugs & Pharmacology Authors: Wang Q, Liu X, Zhu R Tags: Curr Pharm Des Source Type: research

Antenatal Corticosteroids for Fetal Lung Maturity - Too Much of a Good Thing?
CONCLUSION: Further investigations are urgently needed to determine the most safe and effective treatment regimen for antenatal corticosteroids, particularly regarding type of corticosteroid and optimal gestational window of administration. A clear consensus on the use of this common treatment could maximise the benefits and minimise potential harms to offspring. PMID: 30914016 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 26, 2019 Category: Drugs & Pharmacology Authors: Hrabalkova L, Takahashi T, Kemp MW, Stock SJ Tags: Curr Pharm Des Source Type: research

Expression profile of MicroRNA: An Emerging Hallmark of Cancer.
Abstract MicroRNA (miRNAs), a class of small, endogenous non-coding RNA molecules of about 21-24 nucleotides in length, have unraveled a new modulatory network of RNAs that form an additional level of post-transcriptional gene regulation by targeting messenger RNAs (mRNAs). These miRNAs possess the ability to regulate gene expression by modulating the stability of mRNAs, controlling their translation rates, and consequently regulating protein synthesis. Substantial experimental evidence established the involvement of miRNAs in most biological processes like growth, differentiation, development, and metabolism in m...
Source: Current Pharmaceutical Design - March 25, 2019 Category: Drugs & Pharmacology Authors: Zaheer U, Faheem M, Qadri I, Begum N, Yassine HM, Al Thani AA, Mathew S Tags: Curr Pharm Des Source Type: research

Stimuli-responsive Drug Delivery Systems as an Emerging Platform for Treatment of Rheumatoid Arthritis.
Abstract Rheumatoid arthritis (RA) is a systemic autoimmune disease accompanied by chronic inflammation. Due to the long-term infiltration in inflammatory sites, joints were steadily deteriorated, eventually resulting in functional incapacitation and disability. Despite of the considerable effect, RA sufferers treated with current drug therapeutic efficacy were exposed to severe side effects. Application of Drug Delivery Systems (DDS) has improved these situations while remaining the problem of limited drug exposure untackled. Stimuli-responsive DDS that are responsive to a variety of endogenous and exogenous stim...
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Xu XL, Lu KJ, Yao XQ, Ying XY, Du YZ Tags: Curr Pharm Des Source Type: research

Women's Beliefs about Medicines and Adherence to Pharmacotherapy in Pregnancy: Opportunities for Community Pharmacists?
CONCLUSION: Concerns about medication use and non-adherence are widespread among pregnant women. Community pharmacists' counselling during pregnancy is insufficient. Further education, training and research are required to support community pharmacists in fulfilling all the opportunities they have when counselling pregnant women. PMID: 30907309 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Ceulemans M, Lupattelli A, Nordeng H, Odalovic M, Twigg M, Foulon V Tags: Curr Pharm Des Source Type: research

Clinical Pharmacokinetic Studies in Pregnant Women and the Relevance of Pharmacometric Tools.
CONCLUSIONS: pharmacometric tools became very instrumental to improve perinatal pharmacology. However, to reach their full potential, multidisciplinary collaboration and structured efforts are needed to generate more information from already available datasets, to share data and models, and to stimulate cross talk between clinicians and pharmacometricians to generate specific observations (pathophysiology during pregnancy, breastfeeding) needed to further develop the field. PMID: 30894099 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Dallmann A, Mian P, den Anker JV, Allegaert K Tags: Curr Pharm Des Source Type: research

Mobile health applications for prenatal assessment and monitoring.
CONCLUSIONS: Despite the potential advantages of these devices, some caution must be heeded when implementing this technology into routine daily practice. To date, the majority of published research on mobile health in the prenatal setting consists of observational studies and there is a need for high-quality randomized controlled trials to confirm the reported clinical and economic benefits as well as the safety of this technology. There is also a need for guidance and governance on the development and validation of new apps and devices and for the implementation of mobile health technology into healthcare systems in both...
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Gyselaers W, Lanssens D, Perry H, Khalil A Tags: Curr Pharm Des Source Type: research

Sildenafil for Antenatal Treatment of Congenital Diaphragmatic Hernia: from Bench to Bedside.
CONCLUSION: There is preclinical evidence that maternally administered sildenafil prevents the vascular changes that lead to PPH in CDH newborns. The phase I/IIb clinical study together with the p-PBPK model will define the maternal dose needed for a therapeutic effect in the foetus. Foetal safety will be investigated both in the clinical study and in the sheep. The final step will be a multicentre, randomized, placebo-controlled trial. PMID: 30894101 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Russo FM, De Bie F, Hodges R, Flake A, Deprest J Tags: Curr Pharm Des Source Type: research

Next Generation Medical Management of Postpartum Hemorrhage.
CONCLUSION: A promising new approach for management of severe postpartum hemorrhage is using medications that alter coagulation. More data are needed to describe ideal patient populations, dosing, timing of administration, and infusion rate. PMID: 30894102 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Phillips JM, van den Anker JN, Ahmadzia HK Tags: Curr Pharm Des Source Type: research

Pharmacokinetics, Placental and Breastmilk Transfer of Antiretroviral Drugs in Pregnant and Lactating Women Living with HIV.
CONCLUSIONS: Available pharmacological data provide evidence that physiological changes during pregnancy affect maternal and consequently fetal ARV exposure. Limited available data suggest that expression of drug transporters may vary throughout pregnancy and breastfeeding thereby possibly impacting the amount of ARV crossing the placenta and secreted into the breastmilk. The drug transporter role in the fetal/child exposure to maternal ARVs needs to be better understood. Our analysis underscores the need for more pharmacological studies with innovative study design, sparse PK sampling, improved study data reporting and PK...
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Hodel EM, Marzolini C, Waitt C, Rakhmanina N Tags: Curr Pharm Des Source Type: research

Non-clinical Models to Determine Drug Passage into Human Breast Milk.
CONCLUSION: By combining various non-clinical tools (physicochemistry-based, in vitro and PBPK, in vivo animal) for drug milk excretion, valuable and unique information regarding drug milk concentrations during lactation can be obtained. PMID: 30894104 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 20, 2019 Category: Drugs & Pharmacology Authors: Ventrella D, Forni M, Bacci ML, Annaert P Tags: Curr Pharm Des Source Type: research

Circulating Insulin-like Growth Factor-1 Levels in Patients with Rheumatoid Arthritis : A Meta-analysis.
Abstract BACKGROUND AND OBJECTIVES: Insulin-like growth factor-1 (IGF-1) levels have been investigated in rheumatoid arthritis (RA), however, produced inconsistent results. The purpose of this meta-analysis was to derive a more precise conclusion about serum/plasma IGF-1 levels in RA patients. METHODS: PubMed, Embase and the Cochrane Library databases were searched up to December 2018 in English, and the studies comparing serum/plasma IGF-1 levels between RA group and healthy control group were what we are interested in. The Newcastle-Ottawa Scale (NOS) was used to assess the methodology quality of included s...
Source: Current Pharmaceutical Design - March 19, 2019 Category: Drugs & Pharmacology Authors: Zhao YL, Wu J, Zhang TP, Cheng QY, Wang XP, Gu MM, Pan HF, Ye DQ Tags: Curr Pharm Des Source Type: research

Neural Networks in Generalized Epilepsy and Novel Antiepileptic Drugs.
CONCLUSION: In preclinical studies, the GABAB receptor agonist GS 39,783 exerted a good antiepileptic effect. Perampanel, an AMPA receptor antagonist, showed good clinical effects in the treatment of partial-onset seizures and primary generalized tonic-clonic seizures. In this treatment, perampanel can be combined with other antiepileptic drugs. Brivaracetam, which shows a high affinity for the synaptic vesicle 2A, exerted a good efficacy in the treatment of adult focal seizures and secondarily generalized tonic-clonic seizures. PMID: 30892153 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 19, 2019 Category: Drugs & Pharmacology Authors: Werner FM, Coveñas R Tags: Curr Pharm Des Source Type: research

Transcriptional characteristics of activated macrophages.
Abstract Macrophages are key players in human innate immunity that protect the organism from pathologic agents, including infection and malignant cells. The spectrum of their functions includes initiation and maintaining on inflammation, cleaning of pathogens and cell debris, as well as inflammation resolution and tissue remodeling and repair. Such wide spectrum is reflected by the great variety of macrophage phenotypes based on activation of distinct transcription patterns in response to different stimuli. Studying this complexity requires an integrated approach, such as transcriptome studies. For many genes, the...
Source: Current Pharmaceutical Design - March 19, 2019 Category: Drugs & Pharmacology Authors: Glanz V, Myasoedova VA, Sukhorukov V, Grechko A, Zhang D, Romaneneko EB, Orekhova VA, Orekhov A Tags: Curr Pharm Des Source Type: research

Retinal and Choroidal Changes after Anti Vascular Endothelial Growth Factor Therapy for Neovascular Age-related Macular Degeneration.
CONCLUSION: Excessive long-term vascular endothelial growth factor inhibition by an anti-vascular endothelial growth factor agent that is trapped by neuronal and retinal pigment epithelium cells may adversely affect the function of physiological vascular endothelial growth factor and harm retinal cells and vessels. PMID: 30892159 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 19, 2019 Category: Drugs & Pharmacology Authors: Kim SW, Woo JE, Yoon YS, Lee S, Woo JM, Min JK Tags: Curr Pharm Des Source Type: research

Thrombolytic Therapy for Acute Ischemic Stroke: Past and Future.
CONCLUSION: Thrombolytic therapy is sometimes accompanied by harmful hemorrhagic insults; accordingly, a window of time wherein therapy can safely be performed has been established for this approach. Several basic and clinical studies are ongoing to develop next-generation thrombolytic drugs to expand the time window. PMID: 30892155 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 18, 2019 Category: Drugs & Pharmacology Authors: Shibata K, Hashimoto T, Miyazaki T, Miyazaki A, Nobe K Tags: Curr Pharm Des Source Type: research

Therapeutic potential of pigment epithelium-derived factor in cancer.
Abstract Pigment epithelium-derived factor (PEDF) is one of the serine protease inhibitors with multifunctional properties, which is produced by various types of organs and tissues. There is an accumulating body of evidence that PEDF plays an important role in the maintenance of tissue homeostasis. Indeed, PEDF not only works as an endogenous inhibitor of angiogenesis, but also suppresses oxidative stress, inflammatory and thrombotic reactions in cell culture systems, animal models, and humans. Furthermore, we, along with others, have found that PEDF inhibits proliferation of, and induces apoptotic cell death in, ...
Source: Current Pharmaceutical Design - March 18, 2019 Category: Drugs & Pharmacology Authors: Yamagishi SI, Koga Y, Sotokawauchi A, Hashizume N, Fukahori S, Matsui T, Yagi M Tags: Curr Pharm Des Source Type: research

Treatments for iron deficiency (ID): Prospective organic iron fortification.
Abstract Iron deficiency, one of the most common nutritional deficient disorders, frequently affects infants, adolescents and pregnant women and impairs growth, development and immune responses. Iron deficiency may also be secondary to gastrointestinal conditions such as gastrectomy and inflammatory bowel disease, as well as cancer and chronic uremia. Iron supplementation is the most commonly selected treatment option for iron deficiency. This review summarizes the iron compounds currently recommended for the iron fortification of foods and for clinical use. Additionally, this review discusses and compares the imp...
Source: Current Pharmaceutical Design - March 18, 2019 Category: Drugs & Pharmacology Authors: Wan D, Wu Q, Ni H, Liu G, Ruan Z, Yin Y Tags: Curr Pharm Des Source Type: research

Methodological Approaches To Evaluate Fetal Drug Exposure.
CONCLUSIONS: PBPK models appeared to be a very promising tool in order to predict fetal drug exposure in-silico. However, these models mainly picture the end of pregnancy and knowledge regarding both, development of the placental permeability and transporters is strongly needed. PMID: 30892158 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 18, 2019 Category: Drugs & Pharmacology Authors: Bouazza N, Foissac F, Hirt D, Urien S, Benaboud S, Lui G, Treluyer JM Tags: Curr Pharm Des Source Type: research

Emerging Research Paradigm for Infant Drug Exposure Through Breast Milk.
CONCLUSIONS: in order to facilitate participant enrollment and data acquisition in a timely manner, networks of investigators become crucial. PMID: 30887918 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 18, 2019 Category: Drugs & Pharmacology Authors: Ito S Tags: Curr Pharm Des Source Type: research

The Role Of Genetic Polymorphism In The Formation Of Arterial Hypertension, Type 2 Diabetes And Their Comorbidity.
CONCLUSION: Contradictory data on the influence of gene polymorphisms on the formation of AH and DM2 in different populations, as well as a small number of studies of the combined effects of several polymorphisms on the formation of comorbidity, determine the continuation of research in this direction. PMID: 30868946 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2019 Category: Drugs & Pharmacology Authors: Shalimova A, Fadieienko G, Kolesnikova O, Isayeva A, Zlatkina V, Nemtsova V, Prosolenko K, Psarova V, Kyrychenko N, Kochuieva M Tags: Curr Pharm Des Source Type: research

Prunella vulgaris: A comprehensive review of chemical constituents, pharmacological effects and clinical applications.
Abstract Prunella vulgaris (PV) is a perennial herb belonging to the Labiate family and is widely distributed in northeastern Asian countries such as Korea, Japan, and China. It is reported to display diverse biological activities including anti-microbial, anti-cancer, and anti-inflammation as determined by in vitro or in vivo studies. So far, about 200 compounds have been isolated from PV plant and majority of these have been characterized mainly as triterpenoids, sterols and flavonoids, followed by coumarins, phenylpropanoids, polysaccharides and volatile oils. This review summarizes and analyzes the current kno...
Source: Current Pharmaceutical Design - March 13, 2019 Category: Drugs & Pharmacology Authors: Wang SJ, Wang XH, Dai YY, Ma MH, Rahman K, Nian H, Zhang H Tags: Curr Pharm Des Source Type: research

Therapeutic potential of curcumin in the treatment of glioblastoma multiforme.
Abstract Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor. Despite standard multimodality treatment, the highly aggressive nature of GBM makes it one of the deadliest human malignancies. The anti-cancer effects of dietary phytochemicals like curcumin provides new insights to cancer treatment. Evaluation of curcumin's efficacy against different malignancies including glioblastoma has been a motivational research topic and widely studied during the recent decade. In this review, we discuss the recent observations on the potential therapeutic effects of curcumin against glioblastoma. Cur...
Source: Current Pharmaceutical Design - March 13, 2019 Category: Drugs & Pharmacology Authors: Shahcheraghi SH, Zangui M, Lotfi M, Ghayour-Mobarhan M, Ghorbani A, Jaliani HZ, Sadeghnia HR, Sahebkar A Tags: Curr Pharm Des Source Type: research

Current concepts of the Pathogenesis of Aplastic Anemia.
Abstract Abnormal activation of the immune system plays an important role in the pathogenesis of aplastic anemia (AA). Various immune cells and cytokines constitute a complex immune network, leading to bone marrow failure. The known pathogenesis is an increase of the myeloid dendritic cell (mDC)/ plasmacytoid dendritic cell (pDC) ratio, which causes the ratio of T helper (Th)1/Th2 to be skewed in favor of Th1 and eventually leads to an abnormal activation of cytotoxic T lymphocyte (CTL). The antigens that stimulate T cells in the context of AA remain unknown. In this process, regulatory T (Treg), Th17, natural kil...
Source: Current Pharmaceutical Design - March 12, 2019 Category: Drugs & Pharmacology Authors: Liu C, Sun Y, Shao Z Tags: Curr Pharm Des Source Type: research

Genotypic and phenotypic aspects of longevity: results from a Sicilian survey and implication for the prevention and the treatment of age-related diseases.
CONCLUSION: As widely discussed in this review, the explanation of the role of genetics and lifestyle in longevity can provide important information on how to develop drugs and / or behaviours that can slow down or delay ageing. Thus, it will be possible to understand, through a "positive biology" approach, how to prevent and/or reduce elderly frailty and disability. PMID: 30864497 [PubMed - as supplied by publisher] (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 12, 2019 Category: Drugs & Pharmacology Authors: Accardi G, Aprile S, Candore G, Caruso C, Cusimano R, Cristaldi L, Di Bona D, Duro G, Galimberti D, Gambino CM, Ligotti ME, Mazzucco W, Vasto S, Aiello A Tags: Curr Pharm Des Source Type: research