A Review on Novel Therapeutic Modalities and Evidence-based Drug Treatments Against Allergic Rhinitis
Curr Pharm Des. 2024 Mar 14. doi: 10.2174/0113816128295952240306072100. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is an IgE-mediated atopic disease that occurs due to inhaled antigens in the immediate phase. Misdiagnosis, insufficient treatment, or no treatment at all are frequent problems associated with the widespread condition known as chronic allergic rhinitis. AR symptoms include runny, itchy, stuffy, and sneezing noses. Asthma and nasal polyps, for example, sometimes occur simultaneously in patients. In order for people living with AR to be as comfortable and productive as possible, treatment should center...
Source: Current Pharmaceutical Design - March 15, 2024 Category: Drugs & Pharmacology Authors: Bhupendra Sharma Rohitas Deshmukh Source Type: research

A Review on Novel Therapeutic Modalities and Evidence-based Drug Treatments Against Allergic Rhinitis
Curr Pharm Des. 2024 Mar 14. doi: 10.2174/0113816128295952240306072100. Online ahead of print.ABSTRACTAllergic rhinitis (AR) is an IgE-mediated atopic disease that occurs due to inhaled antigens in the immediate phase. Misdiagnosis, insufficient treatment, or no treatment at all are frequent problems associated with the widespread condition known as chronic allergic rhinitis. AR symptoms include runny, itchy, stuffy, and sneezing noses. Asthma and nasal polyps, for example, sometimes occur simultaneously in patients. In order for people living with AR to be as comfortable and productive as possible, treatment should center...
Source: Current Pharmaceutical Design - March 15, 2024 Category: Drugs & Pharmacology Authors: Bhupendra Sharma Rohitas Deshmukh Source Type: research

Advances in the Treatment of Kidney Disorders using Mesenchymal Stem Cells
This article will examine the therapeutic approaches that make use of stem cells for the treatment of kidney disorders. The analysis will cover various cellular sources that have been utilised, potential mechanisms involved, and the outcomes that have been achieved so far.PMID:38482624 | DOI:10.2174/0113816128296105240305110312 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Rishabha Malviya Prerna Uniyal Source Type: research

Specific Targeting of Zinc Transporter LIV-1 with Immunocytokine Containing Anti-LIV-1 VHH and Human IL-2 and Evaluation of its In vitro Antitumor Activity
CONCLUSION: The observed results showed that LIV1-mIL2 immunocytokine could be considered an effective agent in the LIV-1-targeted treatment of cancers due to its longer half-life and stronger cytotoxicity.PMID:38482625 | DOI:10.2174/0113816128295195240305060103 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Rada Dehghan Arezoo Beig Parikhani Reza Ahangari Cohan Mohammad Ali Shokrgozar Esmat Mirabzadeh Soheila Ajdary Sirous Zeinali Hajarossadat Ghaderi Yeganeh Talebkhan Mahdi Behdani Source Type: research

Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases
Curr Pharm Des. 2024 Mar 12. doi: 10.2174/0113816128286655240304070740. Online ahead of print.ABSTRACTNeurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial morphology and metabolic malfunction are found in many neurodegenerative disorders. Alteration in mitochondrial function can occur as a result of aberrant mitochondrial DNA, altered nuclear enzymes that interact with mitochondria actively or passively, or due to unexplained reasons. Mitochondria are intimately linked to the Endoplasmic reticulum (ER), and ER-mitochondrial ...
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Nitu L Wankhede Mayur B Kale Mohit D Umare Sanket Lokhande Aman B Upaganlawar Pranay Wal Brijesh G Taksande Milind J Umekar Prasanna Shama Khandige Bhupendra Singh Vandana Sadananda Seema Ramniwas Tapan Behl Source Type: research

Compounds based on Adamantyl-Substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors
Curr Pharm Des. 2024 Mar 12. doi: 10.2174/0113816128286111240229074810. Online ahead of print.ABSTRACTThe discussion has revolved around the derivatives of amino acids and peptides containing carbocycles and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus. Studies conducted on cell cultures reveal that aminoadamantane amino acid derivatives exhibit the capacity to hinder the replication of viruses containing viroporins. Furthermore, certain compounds demonstrate potent virucidal activity with respect to influenza A/H5N1 and hepatitis C virus particles. A conceptual fram...
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Timur M Garaev Tatyana V Grebennikova Varvara V Lebedeva Varvara V Avdeeva Viktor F Larichev Source Type: research

Deformable Vesicles with Edge Activators for the Transdermal Delivery of Non-Psychoactive Cannabinoids
CONCLUSION: Desoxy-cannabidiol was successfully produced at high yields, and formulated into transethosomes optimized for transdermal delivery. Loaded vesicles showed improved skin penetration of desoxy-cannabidiol, cannabidiol and a lipophilic probe. These results suggest the potential of these carriers for the transdermal delivery of highly lipophilic drugs.PMID:38482628 | DOI:10.2174/0113816128289593240226071813 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Elisa Vettorato Marisa Fiordelisi Silvia Ferro Desir è Zanin Erica Franceschinis Giovanni Marzaro Nicola Realdon Source Type: research

Network Pharmacology Along with Molecular Docking to Explore the Mechanism of Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome Validation
CONCLUSION: The present study suggested that DSI might exert a cardioprotective effect on AIC via the inhibition of CA12, NOS3, and POLH, as well as the modulation of calcium signaling. Further experiments are warranted to verify the findings.PMID:38482629 | DOI:10.2174/0113816128289845240305070522 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Quankai Dai Yijun Pan Xiwen Zhu Mengyao Chen Lin Xie Yu Zhu Guoxing Wan Source Type: research

Advances in the Treatment of Kidney Disorders using Mesenchymal Stem Cells
This article will examine the therapeutic approaches that make use of stem cells for the treatment of kidney disorders. The analysis will cover various cellular sources that have been utilised, potential mechanisms involved, and the outcomes that have been achieved so far.PMID:38482624 | DOI:10.2174/0113816128296105240305110312 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Shivam Rajput Rishabha Malviya Prerna Uniyal Source Type: research

Specific Targeting of Zinc Transporter LIV-1 with Immunocytokine Containing Anti-LIV-1 VHH and Human IL-2 and Evaluation of its In vitro Antitumor Activity
CONCLUSION: The observed results showed that LIV1-mIL2 immunocytokine could be considered an effective agent in the LIV-1-targeted treatment of cancers due to its longer half-life and stronger cytotoxicity.PMID:38482625 | DOI:10.2174/0113816128295195240305060103 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Rada Dehghan Arezoo Beig Parikhani Reza Ahangari Cohan Mohammad Ali Shokrgozar Esmat Mirabzadeh Soheila Ajdary Sirous Zeinali Hajarossadat Ghaderi Yeganeh Talebkhan Mahdi Behdani Source Type: research

Revisiting the Mitochondrial Function and Communication in Neurodegenerative Diseases
Curr Pharm Des. 2024 Mar 12. doi: 10.2174/0113816128286655240304070740. Online ahead of print.ABSTRACTNeurodegenerative disorders are distinguished by the progressive loss of anatomically or physiologically relevant neural systems. Atypical mitochondrial morphology and metabolic malfunction are found in many neurodegenerative disorders. Alteration in mitochondrial function can occur as a result of aberrant mitochondrial DNA, altered nuclear enzymes that interact with mitochondria actively or passively, or due to unexplained reasons. Mitochondria are intimately linked to the Endoplasmic reticulum (ER), and ER-mitochondrial ...
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Nitu L Wankhede Mayur B Kale Mohit D Umare Sanket Lokhande Aman B Upaganlawar Pranay Wal Brijesh G Taksande Milind J Umekar Prasanna Shama Khandige Bhupendra Singh Vandana Sadananda Seema Ramniwas Tapan Behl Source Type: research

Compounds based on Adamantyl-Substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors
Curr Pharm Des. 2024 Mar 12. doi: 10.2174/0113816128286111240229074810. Online ahead of print.ABSTRACTThe discussion has revolved around the derivatives of amino acids and peptides containing carbocycles and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus. Studies conducted on cell cultures reveal that aminoadamantane amino acid derivatives exhibit the capacity to hinder the replication of viruses containing viroporins. Furthermore, certain compounds demonstrate potent virucidal activity with respect to influenza A/H5N1 and hepatitis C virus particles. A conceptual fram...
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Timur M Garaev Tatyana V Grebennikova Varvara V Lebedeva Varvara V Avdeeva Viktor F Larichev Source Type: research

Deformable Vesicles with Edge Activators for the Transdermal Delivery of Non-Psychoactive Cannabinoids
CONCLUSION: Desoxy-cannabidiol was successfully produced at high yields, and formulated into transethosomes optimized for transdermal delivery. Loaded vesicles showed improved skin penetration of desoxy-cannabidiol, cannabidiol and a lipophilic probe. These results suggest the potential of these carriers for the transdermal delivery of highly lipophilic drugs.PMID:38482628 | DOI:10.2174/0113816128289593240226071813 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Elisa Vettorato Marisa Fiordelisi Silvia Ferro Desir è Zanin Erica Franceschinis Giovanni Marzaro Nicola Realdon Source Type: research

Network Pharmacology Along with Molecular Docking to Explore the Mechanism of Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome Validation
CONCLUSION: The present study suggested that DSI might exert a cardioprotective effect on AIC via the inhibition of CA12, NOS3, and POLH, as well as the modulation of calcium signaling. Further experiments are warranted to verify the findings.PMID:38482629 | DOI:10.2174/0113816128289845240305070522 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Quankai Dai Yijun Pan Xiwen Zhu Mengyao Chen Lin Xie Yu Zhu Guoxing Wan Source Type: research

Pharmacological Considerations during Percutaneous Treatment of Heart Failure
This article aimed to provide a comprehensive review of the role of percutaneous interventions in HF patients, with a primary focus on key features, clinical effectiveness, and safety outcomes. Despite the growing utilization of these interventions, there remain critical gaps in the existing body of evidence. Consequently, the need for high-quality randomized clinical trials and extensive international registries is emphasized to shed light on the specific patient populations and clinical scenarios that stand to benefit most from these innovative devices.PMID:38477207 | DOI:10.2174/0113816128284131240209113009 (Source: Cur...
Source: Current Pharmaceutical Design - March 13, 2024 Category: Drugs & Pharmacology Authors: Jose Antonio Sorolla-Romero Javier Navarrete-Navarro Julia Martinez-Sole Hector M Garcia Garcia Jose Luis Diez-Gil Luis Martinez-Dolz Jorge Sanz-Sanchez Source Type: research