Temozolomide: an Overview of Biological Properties, Drug Delivery Nanosystems, and Analytical Methods
Curr Pharm Des. 2022 Jun 3. doi: 10.2174/1381612828666220603152918. Online ahead of print.ABSTRACTTemozolomide (TMZ) is an imidazotetrazine prodrug used to treat glioblastoma multiforme. Its physicochemical prop-erties and small size confer the ability to cross the blood-brain barrier. The antitumor activity depends on pH-dependent hydrolysis of the methyldiazonium cation, which is capable of methylating purine bases (O6-guanine; N7-guanine, and N3-adenine) and causing DNA damage and cell death. TMZ is more stable in acidic media (pH ≤ 5.0) than in basic media (pH ≥ 7.0) due to the protonated form that minimizes the ca...
Source: Current Pharmaceutical Design - June 6, 2022 Category: Drugs & Pharmacology Authors: Jessyca Aparecida Paes Dutra Marcela Tavares Luiz Alberto Gomes Tavares Junior Leonardo Delello Di Filippo Suzana Gon çalves Carvalho Marlus Chorilli Source Type: research

Common ictal and interictal perfusion patterns. A window into the epileptogenic network and SUDEP mechanism in Drug Resistant Focal Epilepsy?
CONCLUSION: The methodology employed made it possible to identify common cortical and subcortical perfusion patterns not directly linked to epileptogenicity, but open a window for the epileptogenic network and sudden unexpected death (SUDEP) mechanism in DRE .PMID:35658889 | DOI:10.2174/1381612828666220603125328 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - June 6, 2022 Category: Drugs & Pharmacology Authors: Lilia M Morales Chac ón Lidice Galan Garc ía Karla Batista Garc ía-Ramón Margarita Minou B áez Martin Jorge Bosch Bayard Maydelis Alfonso Alfonso Sheyla Berrillo Batista Tania de la Paz Bermudez Judith Gonz ález González Abel S ánchez Coroneaux Á Source Type: research

GC-MS identification and quantification of the synthetic cannabinoid MDMB-4en-PINACA in cannabis-derived material seized in the Turin Metropolitan Area (Italy)
CONCLUSIONS: The adulteration of low-THC cannabis products with synthetic cannabinoid receptor agonists is a widespread phenomenon today. Since these substances are potentially more toxic than THC, their consumption poses a high risk of overdose for unaware users and a health-threatening situation. This study confirmed the sporadic presence on the market of CBD-prevalent cannabis products adulterated with MDMB-4en-PINACA.PMID:35658890 | DOI:10.2174/1381612828666220603142859 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - June 6, 2022 Category: Drugs & Pharmacology Authors: Enrico Gerace Fabrizio Seganti Daniele Di Corcia Marco Vincenti Alberto Salomone Source Type: research

Recognizing, Managing and Treating Acute Agitation in Youths
Curr Pharm Des. 2022 Jun 3. doi: 10.2174/1381612828666220603144401. Online ahead of print.ABSTRACTAcute agitation is common in youths presenting to emergency departments, and, in some cases, may escalate into aggression and violence. Therefore, acute agitation in youths should be immediately and appropriately recognized and treated to avoid the consequences of its escalation. Agitation is widespread in youths, being reported in around 7% of all youths admitted to emergency departments due to psychiatric reasons. Overall, the most frequent causes of youth acute agitation include the exacerbation of neurodevelopmental disord...
Source: Current Pharmaceutical Design - June 6, 2022 Category: Drugs & Pharmacology Authors: Virginio Salvi Laura Orsolini Lorenzo Maria Martino Simone Pompili Umberto Volpe Source Type: research

Temozolomide: an Overview of Biological Properties, Drug Delivery Nanosystems, and Analytical Methods
Curr Pharm Des. 2022 Jun 3. doi: 10.2174/1381612828666220603152918. Online ahead of print.ABSTRACTTemozolomide (TMZ) is an imidazotetrazine prodrug used to treat glioblastoma multiforme. Its physicochemical prop-erties and small size confer the ability to cross the blood-brain barrier. The antitumor activity depends on pH-dependent hydrolysis of the methyldiazonium cation, which is capable of methylating purine bases (O6-guanine; N7-guanine, and N3-adenine) and causing DNA damage and cell death. TMZ is more stable in acidic media (pH ≤ 5.0) than in basic media (pH ≥ 7.0) due to the protonated form that minimizes the ca...
Source: Current Pharmaceutical Design - June 6, 2022 Category: Drugs & Pharmacology Authors: Jessyca Aparecida Paes Dutra Marcela Tavares Luiz Alberto Gomes Tavares Junior Leonardo Delello Di Filippo Suzana Gon çalves Carvalho Marlus Chorilli Source Type: research

Common ictal and interictal perfusion patterns. A window into the epileptogenic network and SUDEP mechanism in Drug Resistant Focal Epilepsy?
CONCLUSION: The methodology employed made it possible to identify common cortical and subcortical perfusion patterns not directly linked to epileptogenicity, but open a window for the epileptogenic network and sudden unexpected death (SUDEP) mechanism in DRE .PMID:35658889 | DOI:10.2174/1381612828666220603125328 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - June 6, 2022 Category: Drugs & Pharmacology Authors: Lilia M Morales Chac ón Lidice Galan Garc ía Karla Batista Garc ía-Ramón Margarita Minou B áez Martin Jorge Bosch Bayard Maydelis Alfonso Alfonso Sheyla Berrillo Batista Tania de la Paz Bermudez Judith Gonz ález González Abel S ánchez Coroneaux Á Source Type: research

GC-MS identification and quantification of the synthetic cannabinoid MDMB-4en-PINACA in cannabis-derived material seized in the Turin Metropolitan Area (Italy)
CONCLUSIONS: The adulteration of low-THC cannabis products with synthetic cannabinoid receptor agonists is a widespread phenomenon today. Since these substances are potentially more toxic than THC, their consumption poses a high risk of overdose for unaware users and a health-threatening situation. This study confirmed the sporadic presence on the market of CBD-prevalent cannabis products adulterated with MDMB-4en-PINACA.PMID:35658890 | DOI:10.2174/1381612828666220603142859 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - June 6, 2022 Category: Drugs & Pharmacology Authors: Enrico Gerace Fabrizio Seganti Daniele Di Corcia Marco Vincenti Alberto Salomone Source Type: research

Utility of Indian fruits in cancer prevention and treatment: Time to undertake translational and bedside studies
Curr Pharm Des. 2022 Jun 1. doi: 10.2174/1381612828666220601151931. Online ahead of print.ABSTRACTThe World Health Organization predicts a 70% increase in cancer incidents in developing nations over the next decade, and it will be the second leading cause of death worldwide. Traditional plant-based medicine systems play an important role against various diseases and provide health care to a large section of the population in developing countries. Indigenous fruits and their bioactive compounds with beneficial effects like antioxidant, antiproliferative, and immunomodulatory are shown to be useful in preventing the incidenc...
Source: Current Pharmaceutical Design - June 2, 2022 Category: Drugs & Pharmacology Authors: Pankaj Prabhakar Giriyapura Srikantachar Pavankumar Shamprasad Varija Raghu Suresh Rao Krishna Prasad Thomas George Manjeshwar Shrinath Baliga Source Type: research

Chemotherapeutics activities of dietary phytoestrogens against prostate cancer: From observational to clinical studies
Curr Pharm Des. 2022 Jun 1. doi: 10.2174/1381612828666220601153426. Online ahead of print.ABSTRACTProstate cancer remains one of the most frequent and deadliest malignancies in males, where the rate of disease progression is closely associated with the type of dietary intake, specifically Western-style diet. Indeed intake of the Asian diet, which contains abundant phytoestrogens, is inversely correlated with a higher risk of prostate cancer, suggesting a chemoprotective effect of phytoestrogen against cancer progression. Although the role of phytoestrogens in cancer treatment was well documented, their impact on prostate c...
Source: Current Pharmaceutical Design - June 2, 2022 Category: Drugs & Pharmacology Authors: Md Sohel Habiba Sultana Tayeba Sultana Abdullah Al Mamun Mohammad Nurul Amin Md Arju Hossain Md Chayan Ali Suraiya Aktar Armin Sultana Zahed Bin Rahim Sarmistha Mitra Raju Dash Source Type: research

Utility of Indian fruits in cancer prevention and treatment: Time to undertake translational and bedside studies
Curr Pharm Des. 2022 Jun 1. doi: 10.2174/1381612828666220601151931. Online ahead of print.ABSTRACTThe World Health Organization predicts a 70% increase in cancer incidents in developing nations over the next decade, and it will be the second leading cause of death worldwide. Traditional plant-based medicine systems play an important role against various diseases and provide health care to a large section of the population in developing countries. Indigenous fruits and their bioactive compounds with beneficial effects like antioxidant, antiproliferative, and immunomodulatory are shown to be useful in preventing the incidenc...
Source: Current Pharmaceutical Design - June 2, 2022 Category: Drugs & Pharmacology Authors: Pankaj Prabhakar Giriyapura Srikantachar Pavankumar Shamprasad Varija Raghu Suresh Rao Krishna Prasad Thomas George Manjeshwar Shrinath Baliga Source Type: research

Chemotherapeutics activities of dietary phytoestrogens against prostate cancer: From observational to clinical studies
Curr Pharm Des. 2022 Jun 1. doi: 10.2174/1381612828666220601153426. Online ahead of print.ABSTRACTProstate cancer remains one of the most frequent and deadliest malignancies in males, where the rate of disease progression is closely associated with the type of dietary intake, specifically Western-style diet. Indeed intake of the Asian diet, which contains abundant phytoestrogens, is inversely correlated with a higher risk of prostate cancer, suggesting a chemoprotective effect of phytoestrogen against cancer progression. Although the role of phytoestrogens in cancer treatment was well documented, their impact on prostate c...
Source: Current Pharmaceutical Design - June 2, 2022 Category: Drugs & Pharmacology Authors: Md Sohel Habiba Sultana Tayeba Sultana Abdullah Al Mamun Mohammad Nurul Amin Md Arju Hossain Md Chayan Ali Suraiya Aktar Armin Sultana Zahed Bin Rahim Sarmistha Mitra Raju Dash Source Type: research

Utility of Indian fruits in cancer prevention and treatment: Time to undertake translational and bedside studies
Curr Pharm Des. 2022 Jun 1. doi: 10.2174/1381612828666220601151931. Online ahead of print.ABSTRACTThe World Health Organization predicts a 70% increase in cancer incidents in developing nations over the next decade, and it will be the second leading cause of death worldwide. Traditional plant-based medicine systems play an important role against various diseases and provide health care to a large section of the population in developing countries. Indigenous fruits and their bioactive compounds with beneficial effects like antioxidant, antiproliferative, and immunomodulatory are shown to be useful in preventing the incidenc...
Source: Current Pharmaceutical Design - June 2, 2022 Category: Drugs & Pharmacology Authors: Pankaj Prabhakar Giriyapura Srikantachar Pavankumar Shamprasad Varija Raghu Suresh Rao Krishna Prasad Thomas George Manjeshwar Shrinath Baliga Source Type: research

Chemotherapeutics activities of dietary phytoestrogens against prostate cancer: From observational to clinical studies
Curr Pharm Des. 2022 Jun 1. doi: 10.2174/1381612828666220601153426. Online ahead of print.ABSTRACTProstate cancer remains one of the most frequent and deadliest malignancies in males, where the rate of disease progression is closely associated with the type of dietary intake, specifically Western-style diet. Indeed intake of the Asian diet, which contains abundant phytoestrogens, is inversely correlated with a higher risk of prostate cancer, suggesting a chemoprotective effect of phytoestrogen against cancer progression. Although the role of phytoestrogens in cancer treatment was well documented, their impact on prostate c...
Source: Current Pharmaceutical Design - June 2, 2022 Category: Drugs & Pharmacology Authors: Md Sohel Habiba Sultana Tayeba Sultana Abdullah Al Mamun Mohammad Nurul Amin Md Arju Hossain Md Chayan Ali Suraiya Aktar Armin Sultana Zahed Bin Rahim Sarmistha Mitra Raju Dash Source Type: research

Differential impact of biologic therapy on heart function biomarkers in rheumatoid arthritis patients: Observational study on etanercept, adalimumab and tocilizumab
Conclusion As this biomarker reflects potential heart injury we suggest that heart damage proceeds in continuous manner in RA patients despite effective treatment and attainment of remission/low disease activity. This finding however should be verify in larger cohort of RA patients to ascertain if routine assessment of H-FABP may be useful for detection of patients with RA who are at risk of development of heart damage.PMID:35638285 | DOI:10.2174/1381612828666220527141532 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 31, 2022 Category: Drugs & Pharmacology Authors: Beata Dubiel-Braszczok Karolina Nowak Aleksander Owczarek Ma łgorzata Engelmann Olga Gumkowska-Sroka Przemys ław J Kotyla Source Type: research

Differential impact of biologic therapy on heart function biomarkers in rheumatoid arthritis patients: Observational study on etanercept, adalimumab and tocilizumab
Conclusion As this biomarker reflects potential heart injury we suggest that heart damage proceeds in continuous manner in RA patients despite effective treatment and attainment of remission/low disease activity. This finding however should be verify in larger cohort of RA patients to ascertain if routine assessment of H-FABP may be useful for detection of patients with RA who are at risk of development of heart damage.PMID:35638285 | DOI:10.2174/1381612828666220527141532 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 31, 2022 Category: Drugs & Pharmacology Authors: Beata Dubiel-Braszczok Karolina Nowak Aleksander Owczarek Ma łgorzata Engelmann Olga Gumkowska-Sroka Przemys ław J Kotyla Source Type: research