Innovative Strategies to Enhance mRNA Vaccine Delivery and Effectiveness: Mechanisms and Future Outlook
Curr Pharm Des. 2024 Mar 28. doi: 10.2174/0113816128296588240321072042. Online ahead of print.ABSTRACTThe creation of mRNA vaccines has transformed the area of vaccination and allowed for the production of COVID-19 vaccines with previously unheard-of speed and effectiveness. The development of novel strategies to enhance the delivery and efficiency of mRNA vaccines has been motivated by the ongoing constraints of the present mRNA vaccine delivery systems. In this context, intriguing methods to get beyond these restrictions include lipid nanoparticles, self-amplifying RNA, electroporation, microneedles, and cell-targeted ad...
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Ankit Awasthi Source Type: research
Design of Nanodrug Delivery Systems for Tumor Bone Metastasis
Curr Pharm Des. 2024 Mar 27. doi: 10.2174/0113816128296883240320040636. Online ahead of print.ABSTRACTTumor metastasis is a complex process that is controlled at the molecular level by numerous cytokines. Primary breast and prostate tumors most commonly metastasize to bone, and the development of increasingly accurate targeted nanocarrier systems has become a research focus for more effective anti-bone metastasis therapy. This review summarizes the molecular mechanisms of bone metastasis and the principles and methods for designing bone-targeted nanocarriers and then provides an in-depth review of bone-targeted nanocarrier...
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Xiaoqing Zhai Shan Peng Chunyuan Zhai Shuai Wang Meina Xie Shoudong Guo Jingkun Bai Source Type: research
Cellular and Mitochondrial Pathways Contribute to SGLT2 Inhibitors-mediated Tissue Protection: Experimental and Clinical Data
In conclusion, like a treasure chest brimming with untold riches, the influence of SGLT2i on mitochondrial function holds untold potential for cardiovascular health. Unlocking these secrets, like a map guiding adventurers to hidden riches, promises to pave the way for even more potent therapeutic strategies.PMID:38551044 | DOI:10.2174/0113816128289350240320063045 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Ra úl Lelio Sanz Sebasti án García Menéndez Felipe Inserra Le ón Ferder Walter Manucha Source Type: research
Studies in Solid Solution Formation between Acetaminophen and Povidone and Mouth mouth-dissolving Strip Formulation
CONCLUSION: The developed SS can also be formulated as tablets, capsules, and oral dissolving tablets to deliver adult doses with improved therapeutic benefits and patient compliance.PMID:38551045 | DOI:10.2174/0113816128297499240321034304 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Aliasgar Shahiwala Source Type: research
Innovative Strategies to Enhance mRNA Vaccine Delivery and Effectiveness: Mechanisms and Future Outlook
Curr Pharm Des. 2024 Mar 28. doi: 10.2174/0113816128296588240321072042. Online ahead of print.ABSTRACTThe creation of mRNA vaccines has transformed the area of vaccination and allowed for the production of COVID-19 vaccines with previously unheard-of speed and effectiveness. The development of novel strategies to enhance the delivery and efficiency of mRNA vaccines has been motivated by the ongoing constraints of the present mRNA vaccine delivery systems. In this context, intriguing methods to get beyond these restrictions include lipid nanoparticles, self-amplifying RNA, electroporation, microneedles, and cell-targeted ad...
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Ankit Awasthi Source Type: research
Design of Nanodrug Delivery Systems for Tumor Bone Metastasis
Curr Pharm Des. 2024 Mar 27. doi: 10.2174/0113816128296883240320040636. Online ahead of print.ABSTRACTTumor metastasis is a complex process that is controlled at the molecular level by numerous cytokines. Primary breast and prostate tumors most commonly metastasize to bone, and the development of increasingly accurate targeted nanocarrier systems has become a research focus for more effective anti-bone metastasis therapy. This review summarizes the molecular mechanisms of bone metastasis and the principles and methods for designing bone-targeted nanocarriers and then provides an in-depth review of bone-targeted nanocarrier...
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Xiaoqing Zhai Shan Peng Chunyuan Zhai Shuai Wang Meina Xie Shoudong Guo Jingkun Bai Source Type: research
CASC19: An Oncogenic Long Non-coding RNA in Different Cancers
Curr Pharm Des. 2024 Mar 27. doi: 10.2174/0113816128300061240319034243. Online ahead of print.ABSTRACTA 324 bp lncRNA called CASC19 is found on chromosome 8q24.21. Recent research works have revealed that CASC19 is involved in the prognosis of tumors and related to the regulation of the radiation tolerance mechanisms during tumor radiotherapy (RT). This review sheds light on the changes and roles that CASC19 plays in many tumors and diseases, such as nasopharyngeal carcinoma (NPC), cervical cancer, colorectal cancer (CRC), non-small cell lung cancer (NSCLC), clear cell renal cell carcinoma (ccRCC), gastric cancer (GC), pan...
Source: Current Pharmaceutical Design - March 28, 2024 Category: Drugs & Pharmacology Authors: Yinxin Wu Jie Mou Gang Zhou Chengfu Yuan Source Type: research
GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD
Curr Pharm Des. 2024;30(2):100-114. doi: 10.2174/0113816128283153231226103218.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines are approved to treat NAFLD. Glucagon-like peptide-1 (GLP-1) is an enteropeptide hormone that inhibits glucagon synthesis, promotes insulin sec...
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Haoran Jiang Linquan Zang Source Type: research
Neuro-protective Effect of Acetyl-11-keto- β-boswellic Acid in a Rat Model of Scopolamine-induced Cholinergic Dysfunction
CONCLUSION: The results suggested the effectiveness of AKBA in preventing learning and memory dysfunction induced by scopolamine. Accordingly, these protective effects might be produced by modulating BDNF, cholinergic system function, oxidative stress, and apoptotic markers.PMID:38532323 | DOI:10.2174/0113816128269289231226115446 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Amir Hossein Assaran Mahmoud Hosseini Matin Shirazinia Mohammad Hosein Eshaghi Ghalibaf Farimah Beheshti Leila Mobasheri Farshad Mirzavi Arezoo Rajabian Source Type: research
< em > Capsicum annuum < /em > Oleoresin Nanoemulgel - Design Characterization and < em > In vitro < /em > Investigation of Anticancer and Antimicrobial Activities
CONCLUSION: C. annuum oleoresin and its nanoemulgel can be considered valuable sources for the discovery of new antibacterial, antifungal, and anticancer compounds in the pharmaceutical industry, especially due to their potent activity against various cancer cell lines as well as bacterial and fungal strains.PMID:38532324 | DOI:10.2174/0113816128283684231220062019 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Ahmad M Eid Hiba Natsheh Linda Issa Majdulin Zoabi Monia Amer Effat Mahamid Ahmed Mousa Source Type: research
Exploring the Effect of Xiao-Chai-Hu Decoction on Treating Psoriasis Based on Network Pharmacology and Experiment Validation
CONCLUSION: XCHD showed the therapeutic effect on psoriasis by regulating keratinocyte differentiation, and suppressing inflammation and angiogenesis, which provided a theoretical basis for further experiments and clinical research.PMID:38532341 | DOI:10.2174/0113816128288527240108110844 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Ke He Ziyang Wang Meng Liu Wenqian Du Tingyi Yin Ruimin Bai Qiqi Duan Yuqian Wang Hao Lei Yan Zheng Source Type: research
Enhancing the Antiproliferative Activity of Perillyl Alcohol against Glioblastoma Cell Lines through Synergistic Formulation with Natural Oils
CONCLUSION: The findings indicated that the antiproliferative effect of POH-loaded Nanoemulsion (NE) could be used as a possible anticancer therapy for glioblastoma in vitro, particularly when paired with the tested natural oils. Before asserting that this delivery technique is appropriate for glioblastoma therapy, additional in vitro and in vivo investigations are required.PMID:38532602 | DOI:10.2174/0113816128293758240318080527 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Waleed S Alharbi Abdullah A Alshehri Tarek A Ahmed Shadab Md Alshaimaa M Almehmady Manal A Alshabibi Reem M Altamimi Khalid M El-Say Source Type: research
GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD
Curr Pharm Des. 2024;30(2):100-114. doi: 10.2174/0113816128283153231226103218.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines are approved to treat NAFLD. Glucagon-like peptide-1 (GLP-1) is an enteropeptide hormone that inhibits glucagon synthesis, promotes insulin sec...
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Haoran Jiang Linquan Zang Source Type: research
Neuro-protective Effect of Acetyl-11-keto- β-boswellic Acid in a Rat Model of Scopolamine-induced Cholinergic Dysfunction
CONCLUSION: The results suggested the effectiveness of AKBA in preventing learning and memory dysfunction induced by scopolamine. Accordingly, these protective effects might be produced by modulating BDNF, cholinergic system function, oxidative stress, and apoptotic markers.PMID:38532323 | DOI:10.2174/0113816128269289231226115446 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Amir Hossein Assaran Mahmoud Hosseini Matin Shirazinia Mohammad Hosein Eshaghi Ghalibaf Farimah Beheshti Leila Mobasheri Farshad Mirzavi Arezoo Rajabian Source Type: research
< em > Capsicum annuum < /em > Oleoresin Nanoemulgel - Design Characterization and < em > In vitro < /em > Investigation of Anticancer and Antimicrobial Activities
CONCLUSION: C. annuum oleoresin and its nanoemulgel can be considered valuable sources for the discovery of new antibacterial, antifungal, and anticancer compounds in the pharmaceutical industry, especially due to their potent activity against various cancer cell lines as well as bacterial and fungal strains.PMID:38532324 | DOI:10.2174/0113816128283684231220062019 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Ahmad M Eid Hiba Natsheh Linda Issa Majdulin Zoabi Monia Amer Effat Mahamid Ahmed Mousa Source Type: research
