Liquid Chromatography High Resolution Mass Spectrometry in Forensic Toxicology: What Are the Specifics of Method Development, Validation and Quality Assurance for Comprehensive Screening Approaches?
Curr Pharm Des. 2022 May 26. doi: 10.2174/1381612828666220526152259. Online ahead of print.ABSTRACTThe use of High Resolution Mass Spectrometry (HRMS) has increased over the past decade in clinical and forensic toxicology, especially for comprehensive screening approaches. Despite this, few guidelines of this field have specifically addressed HRMS issues concerning compound identification, validation, measurement uncertainty and quality assurance. To fully implement this technique, certainly in an era in which the quality demands for laboratories are ever increasing due to various norms (e.g. the International Organization...
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Sarah M R Wille Brigitte Desharnais Simona Pichini Annagiulia Di Trana Francesco Paolo Busard ò Dirk K Wissenbach Frank Theodor Peters Source Type: research

Effects of musk volatile compounds on attenuated nerve injury and improving post-cerebral ischemic exercise functions
CONCLUSION: The Volatile compounds of musk can attenuate nerve injury and improving post-cerebral ischemic exercise functions by HIF1A pathways, and the combined data provide novel insight for Musk volatile compounds developed as new drug for improving reperfusion injury in acute ischemic stroke.PMID:35619259 | DOI:10.2174/1381612828666220526154014 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Dan Wang Mengmeng Zhang Chun-Jie Wu Qi Liang Da-Neng Wei Lin He Xun Ye Source Type: research

Review on Artificial Intelligence Based Ophthalmic Application
Curr Pharm Des. 2022 May 20. doi: 10.2174/1381612828666220520112240. Online ahead of print.ABSTRACTArtificial intelligence is the leading branch of technology and innovation. The utility of artificial intelligence in the field of medicine is also remarkable. From drug discovery and development till the introduction of products in the market, artificial intelligence can play its role. As people age, they are more prone to be affected by eye diseases around the globe. Early diagnosis and detection help in minimizing the risk of vision loss and providing a quality life. With the help of artificial intelligence, the workload o...
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Sudhakar Kothandan Arun Radhakrishana Gowthamarajan Kuppusamy Source Type: research

The value of the MicroRNAs on alcoholic addicts: A meta-analytic review
CONCLUSION: This study strongly suggests that dopamine- or GABA-related miRs were mostly upregulated in alcoholism. Our findings revealed that about 9% of miRs were downregulated in alcoholism, including miR-567, miR-126, miR-1, miR-432, and miR-153. To identify other or specific miRs as potential biomarkers in alcoholics, large-scale studies and more clinical work are required.PMID:35619318 | DOI:10.2174/1381612828666220520112928 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Reza Mohebbati Hamid Reza Sadeghnia Source Type: research

HNF1A-AS1 :A tumor-associated long non-coding RNA
CONCLUSION: These studies show that LncRNA-HNF1A-AS1 is closely related to the occurrence development of numerous cancers. Through various molecular mechanisms to regulate tumor growth, HNF1A-AS1 can possibly become the new biological biomarker and therapeutic target for many kinds of tumors.PMID:35619319 | DOI:10.2174/1381612828666220520113846 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Yuling Liu Fangnan Zhao Fangshun Tan Lu Tang Zhuoying Du Jie Mou Gang Zhou Chengfu Yuan Source Type: research

Potential indicators of mitochondrial structure and function
Curr Pharm Des. 2022 May 20. doi: 10.2174/1381612828666220520161200. Online ahead of print.ABSTRACTMitochondria regulate a range of important physiological and biochemical cellular processes including apoptotic cell death, energy production, calcium homeostasis, oxidative stress, and lipid metabolism. Given their role as the 'engines' of cells, their dysfunction is associated with a variety of disease states. Exploring the relationship between mitochondrial function and disease can reveal the mechanism(s) of drug activity and disease pathology. In this review, we summarized the methods of evaluating the structure and funct...
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Xu-Dong He Fan Zhang Ying Huang Jun-Jie Hao Mei Zhang Jin-Biao He Xue-Mei Pu Yan-Juan Li Lei Zi Jie Yu Xing-Xin Yang Source Type: research

Main Diagnostic Methods for Covid-19: Integrative Review
CONCLUSION: Caution should be exercised when interpreting the results for the diagnosis of COVID-19, since the onset of clinical symptoms and laboratory and imaging tests must be taken into account.PMID:35619252 | DOI:10.2174/1381612828666220526113232 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Ana Sara Martins de Campos Giandra Azolini Fernandes de Souza Renan Almeida de Jesus Giuliana Zardeto Guilherme Donadel Mariana Dalmagro J éssica Renata de Almeida Canoff Jaqueline Hoscheid Odair Alberton Daniela de C ássia Faglioni Boleta-Ceranto Danie Source Type: research

Ruscogenin alleviates deep venous thrombosis and pulmonary embolism induced by inferior vena cava stenosis inhibiting MEK/ERK/Egr-1/TF signaling pathway in mice
CONCLUSION: IVCS model contributed to the development of DVT and PE in mice and was associated with increased inflammation. RUS showed therapeutic effects by inhibiting inflammation as well as suppressing the activation of MEK/ERK/Egr-1/TF signaling pathway.PMID:35619253 | DOI:10.2174/1381612828666220526120515 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Yujie Dai Qianliu Zhou Yuankai Liu Xiaojun Chen Fang Li Boyang Yu Yuanyuan Zhang Junping Kou Source Type: research

Development of Simple Dissolution Methods for Felodipine and Combined Amlodipine Besylate -Indapamide Extended Release Tablets without Stationary (Felodipine) Basket
CONCLUSION: Test dissolution methods for Plendil® and Natrilam® tablets produced equivalent dissolution profiles compared to standard methods with stationary basket USP Apparatus II.PMID:35619254 | DOI:10.2174/1381612828666220526122615 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Arslan Javed Ummarah Kanwal Syed Ahmad Nazir Gilani Farhan Akhtar Rahat Shamim Nasir Abbas Nadeem Irfan Bukhari Source Type: research

Discovery of active ingredients in Traditional Chinese Medicine based on odor and flavor compounds analysis
CONCLUSION: This current review provides some guidelines for quality evaluation of food or Chinese medicine.PMID:35619255 | DOI:10.2174/1381612828666220526124239 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Dan Wang Feng Lu Li Ai Chun-Jie Wu Ziqi Liu Mengmeng Zhang Ciping Zhong Source Type: research

Trabectedin in Cancers: Mechanisms and Clinical Applications
Curr Pharm Des. 2022 May 26. doi: 10.2174/1381612828666220526125806. Online ahead of print.ABSTRACTTrabectedin, a tetrahydroisoquinoline alkaloid, is the first marine antineoplastic agent approved with special anticancer mechanisms involving DNA binding, DNA repair pathways, transcription regulation and regulation of the tumor microenvironment. It has favorable clinical applications, especially for the treatment of patients with advanced soft tissue sarcoma, who failed in anthracyclines and ifosfamide therapy or could not receive these agents. Currently, trabectedin monotherapy regimen and regimens of combined therapy with...
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Jiali Wang Pengfei Wang Zheng Zeng Caiji Lin Yiru Lin Danli Cao Wenqing Ma Wenwen Xu Qian Xiang Lingjie Luo Wenxue Wang Yongwei Shi Zixiang Gao Yufan Zhao Huidi Liu Shu-Lin Liu Source Type: research

Controversies In The Pharmacotherapy Of Adolescent Depression
DISCUSSION: Moderate to severe depression should be treated with psychotherapy and/or fluoxetine, the best-supported medication, and treatment-resistant adolescents should always receive combined treatment with psychotherapy. Suicidal ideation, particularly with a plan, should be actively explored before starting an antidepressant, as a reason for the closest monitoring. Emergent suicidality after starting antidepressants, as well as antidepressant-related activation, should also be closely monitored and may lead to antidepressant discontinuation. Although no response to pharmacotherapy and psychotherapy may occur in up to...
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Gabriele Masi Source Type: research

Liquid Chromatography High Resolution Mass Spectrometry in Forensic Toxicology: What Are the Specifics of Method Development, Validation and Quality Assurance for Comprehensive Screening Approaches?
Curr Pharm Des. 2022 May 26. doi: 10.2174/1381612828666220526152259. Online ahead of print.ABSTRACTThe use of High Resolution Mass Spectrometry (HRMS) has increased over the past decade in clinical and forensic toxicology, especially for comprehensive screening approaches. Despite this, few guidelines of this field have specifically addressed HRMS issues concerning compound identification, validation, measurement uncertainty and quality assurance. To fully implement this technique, certainly in an era in which the quality demands for laboratories are ever increasing due to various norms (e.g. the International Organization...
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Sarah M R Wille Brigitte Desharnais Simona Pichini Annagiulia Di Trana Francesco Paolo Busard ò Dirk K Wissenbach Frank Theodor Peters Source Type: research

Effects of musk volatile compounds on attenuated nerve injury and improving post-cerebral ischemic exercise functions
CONCLUSION: The Volatile compounds of musk can attenuate nerve injury and improving post-cerebral ischemic exercise functions by HIF1A pathways, and the combined data provide novel insight for Musk volatile compounds developed as new drug for improving reperfusion injury in acute ischemic stroke.PMID:35619259 | DOI:10.2174/1381612828666220526154014 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Dan Wang Mengmeng Zhang Chun-Jie Wu Qi Liang Da-Neng Wei Lin He Xun Ye Source Type: research

Review on Artificial Intelligence Based Ophthalmic Application
Curr Pharm Des. 2022 May 20. doi: 10.2174/1381612828666220520112240. Online ahead of print.ABSTRACTArtificial intelligence is the leading branch of technology and innovation. The utility of artificial intelligence in the field of medicine is also remarkable. From drug discovery and development till the introduction of products in the market, artificial intelligence can play its role. As people age, they are more prone to be affected by eye diseases around the globe. Early diagnosis and detection help in minimizing the risk of vision loss and providing a quality life. With the help of artificial intelligence, the workload o...
Source: Current Pharmaceutical Design - May 27, 2022 Category: Drugs & Pharmacology Authors: Sudhakar Kothandan Arun Radhakrishana Gowthamarajan Kuppusamy Source Type: research