GLP-1/GLP-1RAs: New Options for the Drug Treatment of NAFLD
Curr Pharm Des. 2024;30(2):100-114. doi: 10.2174/0113816128283153231226103218.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines are approved to treat NAFLD. Glucagon-like peptide-1 (GLP-1) is an enteropeptide hormone that inhibits glucagon synthesis, promotes insulin sec...
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Haoran Jiang Linquan Zang Source Type: research
Neuro-protective Effect of Acetyl-11-keto- β-boswellic Acid in a Rat Model of Scopolamine-induced Cholinergic Dysfunction
CONCLUSION: The results suggested the effectiveness of AKBA in preventing learning and memory dysfunction induced by scopolamine. Accordingly, these protective effects might be produced by modulating BDNF, cholinergic system function, oxidative stress, and apoptotic markers.PMID:38532323 | DOI:10.2174/0113816128269289231226115446 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Amir Hossein Assaran Mahmoud Hosseini Matin Shirazinia Mohammad Hosein Eshaghi Ghalibaf Farimah Beheshti Leila Mobasheri Farshad Mirzavi Arezoo Rajabian Source Type: research
< em > Capsicum annuum < /em > Oleoresin Nanoemulgel - Design Characterization and < em > In vitro < /em > Investigation of Anticancer and Antimicrobial Activities
CONCLUSION: C. annuum oleoresin and its nanoemulgel can be considered valuable sources for the discovery of new antibacterial, antifungal, and anticancer compounds in the pharmaceutical industry, especially due to their potent activity against various cancer cell lines as well as bacterial and fungal strains.PMID:38532324 | DOI:10.2174/0113816128283684231220062019 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Ahmad M Eid Hiba Natsheh Linda Issa Majdulin Zoabi Monia Amer Effat Mahamid Ahmed Mousa Source Type: research
Exploring the Effect of Xiao-Chai-Hu Decoction on Treating Psoriasis Based on Network Pharmacology and Experiment Validation
CONCLUSION: XCHD showed the therapeutic effect on psoriasis by regulating keratinocyte differentiation, and suppressing inflammation and angiogenesis, which provided a theoretical basis for further experiments and clinical research.PMID:38532341 | DOI:10.2174/0113816128288527240108110844 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Ke He Ziyang Wang Meng Liu Wenqian Du Tingyi Yin Ruimin Bai Qiqi Duan Yuqian Wang Hao Lei Yan Zheng Source Type: research
Enhancing the Antiproliferative Activity of Perillyl Alcohol against Glioblastoma Cell Lines through Synergistic Formulation with Natural Oils
CONCLUSION: The findings indicated that the antiproliferative effect of POH-loaded Nanoemulsion (NE) could be used as a possible anticancer therapy for glioblastoma in vitro, particularly when paired with the tested natural oils. Before asserting that this delivery technique is appropriate for glioblastoma therapy, additional in vitro and in vivo investigations are required.PMID:38532602 | DOI:10.2174/0113816128293758240318080527 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 27, 2024 Category: Drugs & Pharmacology Authors: Waleed S Alharbi Abdullah A Alshehri Tarek A Ahmed Shadab Md Alshaimaa M Almehmady Manal A Alshabibi Reem M Altamimi Khalid M El-Say Source Type: research
The Role of Traditional Chinese Medicine and Chinese Pharmacopoeia in the Evaluation and Treatment of COVID-19
This study shed some light on common TCM used for SARS and MERS outbreaks and their effective use for COVID-19 management. This study provides new insights into COVID-19 drug discovery.PMID:38523518 | DOI:10.2174/0113816128217263240220060252 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 25, 2024 Category: Drugs & Pharmacology Authors: Amin Gasmi Sadaf Noor Maryam Dadar Yuliya Semenova Alain Menzel Asma Gasmi Benahmed Geir Bj ørklund Source Type: research
Effectiveness and Safety of Different Oral Anticoagulants with P-glycoprotein/ CYP3A4 Inhibitors: A Network Meta-analysis
CONCLUSION: When concomitantly used with P-gp/CYP3A4 inhibitors, apixaban and edoxaban were associated with a lower risk of bleeding, though no significant difference in effectiveness was observed among all OACs.PMID:38523519 | DOI:10.2174/0113816128293940240315073345 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 25, 2024 Category: Drugs & Pharmacology Authors: Siyu Yang Ye Xu Yang Zhang Dandan Li Xingang Li Source Type: research
Exploration of the Mechanisms Underlying Yu's Enema Formula in Treating Ulcerative Colitis by Blocking the RhoA/ROCK Pathway Based on Network Pharmacology, High-performance Liquid Chromatography Analysis, and Experimental Verification
CONCLUSION: YEF may safeguard the intestinal mucosal barrier in UC by targeting CTNNB1, MAPK1, MAPK3, SRC, STAT3, TLR4, and TP53, while blocking the RhoA/ROCK pathway.PMID:38523541 | DOI:10.2174/0113816128290586240315071044 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 25, 2024 Category: Drugs & Pharmacology Authors: Binbin Liu Jie Zhang Xiaoqi Wang Wei Ye Jiaming Yao Source Type: research
The Role of Traditional Chinese Medicine and Chinese Pharmacopoeia in the Evaluation and Treatment of COVID-19
This study shed some light on common TCM used for SARS and MERS outbreaks and their effective use for COVID-19 management. This study provides new insights into COVID-19 drug discovery.PMID:38523518 | DOI:10.2174/0113816128217263240220060252 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 25, 2024 Category: Drugs & Pharmacology Authors: Amin Gasmi Sadaf Noor Maryam Dadar Yuliya Semenova Alain Menzel Asma Gasmi Benahmed Geir Bj ørklund Source Type: research
Effectiveness and Safety of Different Oral Anticoagulants with P-glycoprotein/ CYP3A4 Inhibitors: A Network Meta-analysis
CONCLUSION: When concomitantly used with P-gp/CYP3A4 inhibitors, apixaban and edoxaban were associated with a lower risk of bleeding, though no significant difference in effectiveness was observed among all OACs.PMID:38523519 | DOI:10.2174/0113816128293940240315073345 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 25, 2024 Category: Drugs & Pharmacology Authors: Siyu Yang Ye Xu Yang Zhang Dandan Li Xingang Li Source Type: research
Exploration of the Mechanisms Underlying Yu's Enema Formula in Treating Ulcerative Colitis by Blocking the RhoA/ROCK Pathway Based on Network Pharmacology, High-performance Liquid Chromatography Analysis, and Experimental Verification
CONCLUSION: YEF may safeguard the intestinal mucosal barrier in UC by targeting CTNNB1, MAPK1, MAPK3, SRC, STAT3, TLR4, and TP53, while blocking the RhoA/ROCK pathway.PMID:38523541 | DOI:10.2174/0113816128290586240315071044 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 25, 2024 Category: Drugs & Pharmacology Authors: Binbin Liu Jie Zhang Xiaoqi Wang Wei Ye Jiaming Yao Source Type: research
Identification of Drug Targets and Agents Associated with Ferroptosis-related Osteoporosis Through Integrated Network Pharmacology and Molecular Docking Technology
CONCLUSION: We examined the relationship between ferroptosis and osteoporosis based on bioinformatics and network pharmacology, presenting a promising direction to the pursuit of the exact molecular mechanism of osteoporosis so that a new target can be discovered for the treatment of osteoporosis.PMID:38509680 | DOI:10.2174/0113816128288225240318045050 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 21, 2024 Category: Drugs & Pharmacology Authors: Kailun Huo Yiqian Yang Tieyi Yang Weiwei Zhang Jin Shao Source Type: research
Identification of Drug Targets and Agents Associated with Ferroptosis-related Osteoporosis Through Integrated Network Pharmacology and Molecular Docking Technology
CONCLUSION: We examined the relationship between ferroptosis and osteoporosis based on bioinformatics and network pharmacology, presenting a promising direction to the pursuit of the exact molecular mechanism of osteoporosis so that a new target can be discovered for the treatment of osteoporosis.PMID:38509680 | DOI:10.2174/0113816128288225240318045050 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 21, 2024 Category: Drugs & Pharmacology Authors: Kailun Huo Yiqian Yang Tieyi Yang Weiwei Zhang Jin Shao Source Type: research
Identification of Drug Targets and Agents Associated with Ferroptosis-related Osteoporosis Through Integrated Network Pharmacology and Molecular Docking Technology
CONCLUSION: We examined the relationship between ferroptosis and osteoporosis based on bioinformatics and network pharmacology, presenting a promising direction to the pursuit of the exact molecular mechanism of osteoporosis so that a new target can be discovered for the treatment of osteoporosis.PMID:38509680 | DOI:10.2174/0113816128288225240318045050 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 21, 2024 Category: Drugs & Pharmacology Authors: Kailun Huo Yiqian Yang Tieyi Yang Weiwei Zhang Jin Shao Source Type: research
Identification of Drug Targets and Agents Associated with Ferroptosis-related Osteoporosis Through Integrated Network Pharmacology and Molecular Docking Technology
CONCLUSION: We examined the relationship between ferroptosis and osteoporosis based on bioinformatics and network pharmacology, presenting a promising direction to the pursuit of the exact molecular mechanism of osteoporosis so that a new target can be discovered for the treatment of osteoporosis.PMID:38509680 | DOI:10.2174/0113816128288225240318045050 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 21, 2024 Category: Drugs & Pharmacology Authors: Kailun Huo Yiqian Yang Tieyi Yang Weiwei Zhang Jin Shao Source Type: research
