Breast Cancer-related Lymphedema: Recent Updates on Clinical Efficacy of Therapies and Bioengineering Approaches for a Personalized Therapy
CONCLUSION: As such, currently, a strong foundation for further research into molecular-genetic changes in lymphedema tissue exists, and further research should focus on finding specific targets for personalized treatment through bi-engineering approaches.PMID:38141193 | DOI:10.2174/0113816128269545231218075040 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Xinliang Zhang Narasimha M Beeraka Mikhail Y Sinelnikov Oleg S Glazachev Konstantin S Ternovoy Pengwei Lu Aida Isaeva Yu Cao Jin Zhang Arshia Bakhtiari Nezhad Maria Plotnikova Kuo Chen Source Type: research
Deciphering Potential Role of Hippo Signaling Pathway in Breast Cancer: A Comprehensive Review
Curr Pharm Des. 2023 Dec 21. doi: 10.2174/0113816128274418231215054210. Online ahead of print.ABSTRACTBreast cancer is a heterogeneous disease and a leading malignancy around the world. It is a vital cause of untimely mortality among women. Drug resistance is the major challenge for effective cancer therapeutics. In contrast, cancer stem cells (CSCs) are one of the reasons for drug resistance, tumor progression, and metastasis. The small population of CSCs present in each tumor has the ability of self-renewal, differentiation, and tumorigenicity. CSCs are often identified and enriched using a variety of cell surface marker...
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Hunayna M Bhavnagari Apexa P Raval Franky D Shah Source Type: research
Privileged Scaffolds in Drug Discovery against Human Epidermal Growth Factor Receptor 2 for Cancer Treatment
Curr Pharm Des. 2023 Dec 21. doi: 10.2174/0113816128283615231218094706. Online ahead of print.ABSTRACTHER2 is the membrane receptor tyrosine kinase showing overexpression in several human malignancies, particularly breast cancer. HER2 overexpression causes the activation of Ras- MAPK and PI3K/Akt/ NF-κB cellular signal transduction pathways that lead to cancer development and progression. HER2 is, therefore, presumed as one of the key targets for the development of tumor-specific therapies. Several preclinical have been developed that function by inhibiting the HER2 tyrosine kinase activity through the prevention of the d...
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Mudasir Nabi Peerzada Rania Hamdy Masood Ahmad Rizvi Saurabh Verma Source Type: research
Breast Cancer-related Lymphedema: Recent Updates on Clinical Efficacy of Therapies and Bioengineering Approaches for a Personalized Therapy
CONCLUSION: As such, currently, a strong foundation for further research into molecular-genetic changes in lymphedema tissue exists, and further research should focus on finding specific targets for personalized treatment through bi-engineering approaches.PMID:38141193 | DOI:10.2174/0113816128269545231218075040 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Xinliang Zhang Narasimha M Beeraka Mikhail Y Sinelnikov Oleg S Glazachev Konstantin S Ternovoy Pengwei Lu Aida Isaeva Yu Cao Jin Zhang Arshia Bakhtiari Nezhad Maria Plotnikova Kuo Chen Source Type: research
Deciphering Potential Role of Hippo Signaling Pathway in Breast Cancer: A Comprehensive Review
Curr Pharm Des. 2023 Dec 21. doi: 10.2174/0113816128274418231215054210. Online ahead of print.ABSTRACTBreast cancer is a heterogeneous disease and a leading malignancy around the world. It is a vital cause of untimely mortality among women. Drug resistance is the major challenge for effective cancer therapeutics. In contrast, cancer stem cells (CSCs) are one of the reasons for drug resistance, tumor progression, and metastasis. The small population of CSCs present in each tumor has the ability of self-renewal, differentiation, and tumorigenicity. CSCs are often identified and enriched using a variety of cell surface marker...
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Hunayna M Bhavnagari Apexa P Raval Franky D Shah Source Type: research
Privileged Scaffolds in Drug Discovery against Human Epidermal Growth Factor Receptor 2 for Cancer Treatment
Curr Pharm Des. 2023 Dec 21. doi: 10.2174/0113816128283615231218094706. Online ahead of print.ABSTRACTHER2 is the membrane receptor tyrosine kinase showing overexpression in several human malignancies, particularly breast cancer. HER2 overexpression causes the activation of Ras- MAPK and PI3K/Akt/ NF-κB cellular signal transduction pathways that lead to cancer development and progression. HER2 is, therefore, presumed as one of the key targets for the development of tumor-specific therapies. Several preclinical have been developed that function by inhibiting the HER2 tyrosine kinase activity through the prevention of the d...
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Mudasir Nabi Peerzada Rania Hamdy Masood Ahmad Rizvi Saurabh Verma Source Type: research
Breast Cancer-related Lymphedema: Recent Updates on Clinical Efficacy of Therapies and Bioengineering Approaches for a Personalized Therapy
CONCLUSION: As such, currently, a strong foundation for further research into molecular-genetic changes in lymphedema tissue exists, and further research should focus on finding specific targets for personalized treatment through bi-engineering approaches.PMID:38141193 | DOI:10.2174/0113816128269545231218075040 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Xinliang Zhang Narasimha M Beeraka Mikhail Y Sinelnikov Oleg S Glazachev Konstantin S Ternovoy Pengwei Lu Aida Isaeva Yu Cao Jin Zhang Arshia Bakhtiari Nezhad Maria Plotnikova Kuo Chen Source Type: research
Deciphering Potential Role of Hippo Signaling Pathway in Breast Cancer: A Comprehensive Review
Curr Pharm Des. 2023 Dec 21. doi: 10.2174/0113816128274418231215054210. Online ahead of print.ABSTRACTBreast cancer is a heterogeneous disease and a leading malignancy around the world. It is a vital cause of untimely mortality among women. Drug resistance is the major challenge for effective cancer therapeutics. In contrast, cancer stem cells (CSCs) are one of the reasons for drug resistance, tumor progression, and metastasis. The small population of CSCs present in each tumor has the ability of self-renewal, differentiation, and tumorigenicity. CSCs are often identified and enriched using a variety of cell surface marker...
Source: Current Pharmaceutical Design - December 23, 2023 Category: Drugs & Pharmacology Authors: Hunayna M Bhavnagari Apexa P Raval Franky D Shah Source Type: research
Smart Stimuli-responsive Alginate Nanogels for Drug Delivery Systems and Cancer Therapy: A Review
Curr Pharm Des. 2023 Dec 19. doi: 10.2174/0113816128283806231211073031. Online ahead of print.ABSTRACTNanogels are three-dimensional networks at the nanoscale level that can be fabricated through physical or chemical processes using polymers. These nanoparticles' biocompatibility, notable stability, efficacious drug-loading capacity, and ligand-binding proficiency make them highly suitable for employment as drug-delivery vehicles. In addition, they exhibit the ability to react to both endogenous and exogenous stimuli, which may include factors such as temperature, illumination, pH levels, and a diverse range of other facto...
Source: Current Pharmaceutical Design - December 20, 2023 Category: Drugs & Pharmacology Authors: Seyed Morteza Naghib Hamid Reza Garshasbi Source Type: research
Smart Stimuli-responsive Alginate Nanogels for Drug Delivery Systems and Cancer Therapy: A Review
Curr Pharm Des. 2023 Dec 19. doi: 10.2174/0113816128283806231211073031. Online ahead of print.ABSTRACTNanogels are three-dimensional networks at the nanoscale level that can be fabricated through physical or chemical processes using polymers. These nanoparticles' biocompatibility, notable stability, efficacious drug-loading capacity, and ligand-binding proficiency make them highly suitable for employment as drug-delivery vehicles. In addition, they exhibit the ability to react to both endogenous and exogenous stimuli, which may include factors such as temperature, illumination, pH levels, and a diverse range of other facto...
Source: Current Pharmaceutical Design - December 20, 2023 Category: Drugs & Pharmacology Authors: Seyed Morteza Naghib Hamid Reza Garshasbi Source Type: research
Smart Stimuli-responsive Alginate Nanogels for Drug Delivery Systems and Cancer Therapy: A Review
Curr Pharm Des. 2023 Dec 19. doi: 10.2174/0113816128283806231211073031. Online ahead of print.ABSTRACTNanogels are three-dimensional networks at the nanoscale level that can be fabricated through physical or chemical processes using polymers. These nanoparticles' biocompatibility, notable stability, efficacious drug-loading capacity, and ligand-binding proficiency make them highly suitable for employment as drug-delivery vehicles. In addition, they exhibit the ability to react to both endogenous and exogenous stimuli, which may include factors such as temperature, illumination, pH levels, and a diverse range of other facto...
Source: Current Pharmaceutical Design - December 20, 2023 Category: Drugs & Pharmacology Authors: Seyed Morteza Naghib Hamid Reza Garshasbi Source Type: research
Smart Stimuli-responsive Alginate Nanogels for Drug Delivery Systems and Cancer Therapy: A Review
Curr Pharm Des. 2023 Dec 19. doi: 10.2174/0113816128283806231211073031. Online ahead of print.ABSTRACTNanogels are three-dimensional networks at the nanoscale level that can be fabricated through physical or chemical processes using polymers. These nanoparticles' biocompatibility, notable stability, efficacious drug-loading capacity, and ligand-binding proficiency make them highly suitable for employment as drug-delivery vehicles. In addition, they exhibit the ability to react to both endogenous and exogenous stimuli, which may include factors such as temperature, illumination, pH levels, and a diverse range of other facto...
Source: Current Pharmaceutical Design - December 20, 2023 Category: Drugs & Pharmacology Authors: Seyed Morteza Naghib Hamid Reza Garshasbi Source Type: research
Review on the Artificial Intelligence-based Nanorobotics Targeted Drug Delivery System for Brain-specific Targeting
In conclusion, integrating machine learning and AI with robotics aims to develop safe nanorobots capable of interacting with the BBB without adverse effects. This comprehensive review is valuable for extensive analysis and is of great significance to healthcare professionals, engineers specializing in robotics, chemists, and bioengineers involved in pharmaceutical development and neurological research, emphasizing transdisciplinary approaches.PMID:38111114 | DOI:10.2174/0113816128279248231210172053 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 19, 2023 Category: Drugs & Pharmacology Authors: Akriti Rai Kamal Shah Hitesh Kumar Dewangan Source Type: research
Simultaneous Study of Analysis of Anti-inflammatory Potential of Dryopteris ramosa (C. Hope) C. Chr. using GC- Mass and Computational Modeling on the Xylene- Induced Ear Oedema in Mouse Model
CONCLUSION: The outcome of the study signifies that MEDR can offer a new prospect in the discovery of a harmonizing and alternative therapy for inflammatory disease conditions.PMID:38111115 | DOI:10.2174/0113816128290636231129074039 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 19, 2023 Category: Drugs & Pharmacology Authors: Khalil Said Muhammad Hamayun Mamoona Rauf Sumera Afzal Khan Muhammad Arif Abdulwahed Fahad Alrefaei Mikhlid H Almutairi Sajid Ali Source Type: research
Peptide Polyagonists for the Treatment of Nonalcoholic Fatty Liver Disease
Curr Pharm Des. 2023 Dec 18. doi: 10.2174/0113816128279822231211101522. Online ahead of print.NO ABSTRACTPMID:38111116 | DOI:10.2174/0113816128279822231211101522 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 19, 2023 Category: Drugs & Pharmacology Authors: Stergios A Polyzos Gema Fr ühbeck Dimitrios N Kiortsis Source Type: research
