Challenging Axillary Lymph Nodes on PET/CT in Cancer Patients Throughout COVID-19 Vaccination Era
CONCLUSION: The correct interpretation of images is crucial to avoid unnecessary treatments and invasive procedures in vaccinated cancer pts. A detailed anamnestic interview and the analysis of lymph nodes' CT characteristics, after performing PET/CT, may help to clear any misleading diagnosis.PMID:38454762 | DOI:10.2174/0113816128246329231016091519 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Alessia Giordano Rosj Gallicchio Mariarita Milella Rebecca Storto Anna Nardelli Teresa Pellegrino Antonio Nappi Michele Di Cosola Giovanni Storto Source Type: research
Remedial Dosing Recommendations for Sirolimus Delayed or Missed Dosages Caused by Poor Medication Compliance in Pediatric Tuberous Sclerosis Complex Patients
CONCLUSION: It was the first time to recommend remedial dosages for delayed or missed sirolimus therapy caused by poor medication compliance in pediatric TSC patients based on Monte Carlo simulation. Meanwhile, the present study provided a potential solution for delayed or missed dosages in clinical practice.PMID:38454763 | DOI:10.2174/0113816128299479240213151714 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Yang Yang Lei Jiang Hai-Rong Zhu Wen-Xin Sun Jing-Yu Mao Jing-Wen Miao Yi-Chen Wang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research
Challenging Axillary Lymph Nodes on PET/CT in Cancer Patients Throughout COVID-19 Vaccination Era
CONCLUSION: The correct interpretation of images is crucial to avoid unnecessary treatments and invasive procedures in vaccinated cancer pts. A detailed anamnestic interview and the analysis of lymph nodes' CT characteristics, after performing PET/CT, may help to clear any misleading diagnosis.PMID:38454762 | DOI:10.2174/0113816128246329231016091519 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Alessia Giordano Rosj Gallicchio Mariarita Milella Rebecca Storto Anna Nardelli Teresa Pellegrino Antonio Nappi Michele Di Cosola Giovanni Storto Source Type: research
Remedial Dosing Recommendations for Sirolimus Delayed or Missed Dosages Caused by Poor Medication Compliance in Pediatric Tuberous Sclerosis Complex Patients
CONCLUSION: It was the first time to recommend remedial dosages for delayed or missed sirolimus therapy caused by poor medication compliance in pediatric TSC patients based on Monte Carlo simulation. Meanwhile, the present study provided a potential solution for delayed or missed dosages in clinical practice.PMID:38454763 | DOI:10.2174/0113816128299479240213151714 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Yang Yang Lei Jiang Hai-Rong Zhu Wen-Xin Sun Jing-Yu Mao Jing-Wen Miao Yi-Chen Wang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research
Challenging Axillary Lymph Nodes on PET/CT in Cancer Patients Throughout COVID-19 Vaccination Era
CONCLUSION: The correct interpretation of images is crucial to avoid unnecessary treatments and invasive procedures in vaccinated cancer pts. A detailed anamnestic interview and the analysis of lymph nodes' CT characteristics, after performing PET/CT, may help to clear any misleading diagnosis.PMID:38454762 | DOI:10.2174/0113816128246329231016091519 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Alessia Giordano Rosj Gallicchio Mariarita Milella Rebecca Storto Anna Nardelli Teresa Pellegrino Antonio Nappi Michele Di Cosola Giovanni Storto Source Type: research
Remedial Dosing Recommendations for Sirolimus Delayed or Missed Dosages Caused by Poor Medication Compliance in Pediatric Tuberous Sclerosis Complex Patients
CONCLUSION: It was the first time to recommend remedial dosages for delayed or missed sirolimus therapy caused by poor medication compliance in pediatric TSC patients based on Monte Carlo simulation. Meanwhile, the present study provided a potential solution for delayed or missed dosages in clinical practice.PMID:38454763 | DOI:10.2174/0113816128299479240213151714 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Yang Yang Lei Jiang Hai-Rong Zhu Wen-Xin Sun Jing-Yu Mao Jing-Wen Miao Yi-Chen Wang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research
Machine-learning-guided Directed Evolution for AAV Capsid Engineering
Curr Pharm Des. 2024 Mar 5. doi: 10.2174/0113816128286593240226060318. Online ahead of print.ABSTRACTTarget gene delivery is crucial to gene therapy. Adeno-associated virus (AAV) has emerged as a primary gene therapy vector due to its broad host range, long-term expression, and low pathogenicity. However, AAV vectors have some limitations, such as immunogenicity and insufficient targeting. Designing or modifying capsids is a potential method of improving the efficacy of gene delivery, but hindered by weak biological basis of AAV, complexity of the capsids, and limitations of current screening methods. Artificial intelligen...
Source: Current Pharmaceutical Design - March 6, 2024 Category: Drugs & Pharmacology Authors: Xianrong Fu Hairui Suo Jiachen Zhang Dongmei Chen Source Type: research
Machine-learning-guided Directed Evolution for AAV Capsid Engineering
Curr Pharm Des. 2024 Mar 5. doi: 10.2174/0113816128286593240226060318. Online ahead of print.ABSTRACTTarget gene delivery is crucial to gene therapy. Adeno-associated virus (AAV) has emerged as a primary gene therapy vector due to its broad host range, long-term expression, and low pathogenicity. However, AAV vectors have some limitations, such as immunogenicity and insufficient targeting. Designing or modifying capsids is a potential method of improving the efficacy of gene delivery, but hindered by weak biological basis of AAV, complexity of the capsids, and limitations of current screening methods. Artificial intelligen...
Source: Current Pharmaceutical Design - March 6, 2024 Category: Drugs & Pharmacology Authors: Xianrong Fu Hairui Suo Jiachen Zhang Dongmei Chen Source Type: research
The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy
Curr Pharm Des. 2024 Mar 1. doi: 10.2174/0113816128295414240221063434. Online ahead of print.ABSTRACTThis review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within the embryonic landscape of nanotechnology. Nanoparticles, pivotal in cancer treatment, are systematically examined for their diverse physicochemical structures, categorized as organic (lipid-based, protein-based, and polymer-assisted) and inorganic (carbon-based and metal) varieties. A significant focus is placed on CMNPs, which serve as an innovative drug delivery vehicle, ove...
Source: Current Pharmaceutical Design - March 5, 2024 Category: Drugs & Pharmacology Authors: Sankha Bhattacharya Paul Beninger Source Type: research
The Emerging Role of Cell Membrane-coated Nanomaterials in Cancer Therapy
Curr Pharm Des. 2024 Mar 1. doi: 10.2174/0113816128295414240221063434. Online ahead of print.ABSTRACTThis review investigates the revolutionary application of cell membrane-coated nanoparticles (CMNPs) as a promising avenue for cancer therapy within the embryonic landscape of nanotechnology. Nanoparticles, pivotal in cancer treatment, are systematically examined for their diverse physicochemical structures, categorized as organic (lipid-based, protein-based, and polymer-assisted) and inorganic (carbon-based and metal) varieties. A significant focus is placed on CMNPs, which serve as an innovative drug delivery vehicle, ove...
Source: Current Pharmaceutical Design - March 5, 2024 Category: Drugs & Pharmacology Authors: Sankha Bhattacharya Paul Beninger Source Type: research
Cholesteryl Ester Transfer Protein (CETP) Variations in Relation to Lipid Profiles and Cardiovascular Diseases: An Update
Curr Pharm Des. 2024 Feb 29. doi: 10.2174/0113816128284695240219093612. Online ahead of print.ABSTRACTLipid metabolism plays an essential role in the pathogenesis of cardiovascular and metabolic diseases. Cholesteryl ester transfer protein (CETP) is a crucial glycoprotein involved in lipid metabolism by transferring cholesteryl esters (CE) and triglycerides (TG) between plasma lipoproteins. CETP activity results in reduced HDL-C and increased VLDL- and LDL-C concentrations, thus increasing the risk of cardiovascular and metabolic diseases. In this review, we discuss the structure of CETP and its mechanism of action. Furthe...
Source: Current Pharmaceutical Design - March 1, 2024 Category: Drugs & Pharmacology Authors: Siarhei Dabravolski Nikolay A Orekhov Alexandra Melnichenko Vasily N Sukhorukov Mikhail A Popov Alexander Orekhov Source Type: research
Cholesteryl Ester Transfer Protein (CETP) Variations in Relation to Lipid Profiles and Cardiovascular Diseases: An Update
Curr Pharm Des. 2024 Feb 29. doi: 10.2174/0113816128284695240219093612. Online ahead of print.ABSTRACTLipid metabolism plays an essential role in the pathogenesis of cardiovascular and metabolic diseases. Cholesteryl ester transfer protein (CETP) is a crucial glycoprotein involved in lipid metabolism by transferring cholesteryl esters (CE) and triglycerides (TG) between plasma lipoproteins. CETP activity results in reduced HDL-C and increased VLDL- and LDL-C concentrations, thus increasing the risk of cardiovascular and metabolic diseases. In this review, we discuss the structure of CETP and its mechanism of action. Furthe...
Source: Current Pharmaceutical Design - March 1, 2024 Category: Drugs & Pharmacology Authors: Siarhei Dabravolski Nikolay A Orekhov Alexandra Melnichenko Vasily N Sukhorukov Mikhail A Popov Alexander Orekhov Source Type: research
Cholesteryl Ester Transfer Protein (CETP) Variations in Relation to Lipid Profiles and Cardiovascular Diseases: An Update
Curr Pharm Des. 2024 Feb 29. doi: 10.2174/0113816128284695240219093612. Online ahead of print.ABSTRACTLipid metabolism plays an essential role in the pathogenesis of cardiovascular and metabolic diseases. Cholesteryl ester transfer protein (CETP) is a crucial glycoprotein involved in lipid metabolism by transferring cholesteryl esters (CE) and triglycerides (TG) between plasma lipoproteins. CETP activity results in reduced HDL-C and increased VLDL- and LDL-C concentrations, thus increasing the risk of cardiovascular and metabolic diseases. In this review, we discuss the structure of CETP and its mechanism of action. Furthe...
Source: Current Pharmaceutical Design - March 1, 2024 Category: Drugs & Pharmacology Authors: Siarhei Dabravolski Nikolay A Orekhov Alexandra Melnichenko Vasily N Sukhorukov Mikhail A Popov Alexander Orekhov Source Type: research
Cholesteryl Ester Transfer Protein (CETP) Variations in Relation to Lipid Profiles and Cardiovascular Diseases: An Update
Curr Pharm Des. 2024 Feb 29. doi: 10.2174/0113816128284695240219093612. Online ahead of print.ABSTRACTLipid metabolism plays an essential role in the pathogenesis of cardiovascular and metabolic diseases. Cholesteryl ester transfer protein (CETP) is a crucial glycoprotein involved in lipid metabolism by transferring cholesteryl esters (CE) and triglycerides (TG) between plasma lipoproteins. CETP activity results in reduced HDL-C and increased VLDL- and LDL-C concentrations, thus increasing the risk of cardiovascular and metabolic diseases. In this review, we discuss the structure of CETP and its mechanism of action. Furthe...
Source: Current Pharmaceutical Design - March 1, 2024 Category: Drugs & Pharmacology Authors: Siarhei Dabravolski Nikolay A Orekhov Alexandra Melnichenko Vasily N Sukhorukov Mikhail A Popov Alexander Orekhov Source Type: research
Cumulative Exposure to Oxidized Low-density Lipoprotein is a Potential Predictor for Prognosis in Acute Ischemic Stroke: A Cohort Study
CONCLUSION: Cumulative ox-LDL exposure has a positive correlation with poor prognosis at 90 days of AIS, and has a more accurate predictive ability than cumulative LDL exposure.PMID:38424424 | DOI:10.2174/0113816128280291240220093912 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - February 29, 2024 Category: Drugs & Pharmacology Authors: Kaili Cheng Xiuqi Chen Yufan Luo Wenbo Sun Xiaoli Yang Shengwen Huang Yuanyuan Wang Danhong Wu Source Type: research
