Compounds based on Adamantyl-Substituted Amino Acids and Peptides as Potential Antiviral Drugs Acting as Viroporin Inhibitors
Curr Pharm Des. 2024 Mar 12. doi: 10.2174/0113816128286111240229074810. Online ahead of print.ABSTRACTThe discussion has revolved around the derivatives of amino acids and peptides containing carbocycles and their potential antiviral activity in vitro against influenza A, hepatitis C viruses, and coronavirus. Studies conducted on cell cultures reveal that aminoadamantane amino acid derivatives exhibit the capacity to hinder the replication of viruses containing viroporins. Furthermore, certain compounds demonstrate potent virucidal activity with respect to influenza A/H5N1 and hepatitis C virus particles. A conceptual fram...
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Timur M Garaev Tatyana V Grebennikova Varvara V Lebedeva Varvara V Avdeeva Viktor F Larichev Source Type: research
Deformable Vesicles with Edge Activators for the Transdermal Delivery of Non-Psychoactive Cannabinoids
CONCLUSION: Desoxy-cannabidiol was successfully produced at high yields, and formulated into transethosomes optimized for transdermal delivery. Loaded vesicles showed improved skin penetration of desoxy-cannabidiol, cannabidiol and a lipophilic probe. These results suggest the potential of these carriers for the transdermal delivery of highly lipophilic drugs.PMID:38482628 | DOI:10.2174/0113816128289593240226071813 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Elisa Vettorato Marisa Fiordelisi Silvia Ferro Desir è Zanin Erica Franceschinis Giovanni Marzaro Nicola Realdon Source Type: research
Network Pharmacology Along with Molecular Docking to Explore the Mechanism of Danshen Injection against Anthracycline-induced Cardiotoxicity and Transcriptome Validation
CONCLUSION: The present study suggested that DSI might exert a cardioprotective effect on AIC via the inhibition of CA12, NOS3, and POLH, as well as the modulation of calcium signaling. Further experiments are warranted to verify the findings.PMID:38482629 | DOI:10.2174/0113816128289845240305070522 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 14, 2024 Category: Drugs & Pharmacology Authors: Quankai Dai Yijun Pan Xiwen Zhu Mengyao Chen Lin Xie Yu Zhu Guoxing Wan Source Type: research
Pharmacological Considerations during Percutaneous Treatment of Heart Failure
This article aimed to provide a comprehensive review of the role of percutaneous interventions in HF patients, with a primary focus on key features, clinical effectiveness, and safety outcomes. Despite the growing utilization of these interventions, there remain critical gaps in the existing body of evidence. Consequently, the need for high-quality randomized clinical trials and extensive international registries is emphasized to shed light on the specific patient populations and clinical scenarios that stand to benefit most from these innovative devices.PMID:38477207 | DOI:10.2174/0113816128284131240209113009 (Source: Cur...
Source: Current Pharmaceutical Design - March 13, 2024 Category: Drugs & Pharmacology Authors: Jose Antonio Sorolla-Romero Javier Navarrete-Navarro Julia Martinez-Sole Hector M Garcia Garcia Jose Luis Diez-Gil Luis Martinez-Dolz Jorge Sanz-Sanchez Source Type: research
The Potential of Natural Products in the Management of Cardiovascular Disease
Curr Pharm Des. 2024 Feb 20. doi: 10.2174/0113816128295053240207090928. Online ahead of print.ABSTRACTCardiovascular Disease (CVD) is one of the most prevalent diseases in the world, comprising a variety of disorders such as hypertension, heart attacks, Peripheral Vascular Disease (PVD), dyslipidemias, strokes, coronary heart disease, and cardiomyopathies. The World Health Organization (WHO) predicts that 22.2 million people will die from CVD in 2030. Conventional treatments for CVDs are often quite expensive and also have several side effects. This potentiates the use of medicinal plants, which are still a viable alternat...
Source: Current Pharmaceutical Design - March 13, 2024 Category: Drugs & Pharmacology Authors: Harshita Singhai Sunny Rathee Sanjay K Jain Umesh Kumar Patil Source Type: research
Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease
Curr Pharm Des. 2024 Feb 19. doi: 10.2174/0113816128291248240131102709. Online ahead of print.ABSTRACTChronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of renal function, and plays a crucial role in the pathophysiology and progression of the disease. Si...
Source: Current Pharmaceutical Design - March 13, 2024 Category: Drugs & Pharmacology Authors: Zaobin Chen Yongda Lin Jiali Wang Kaijin Yao Yina Xie Xiutian Chen Tianbiao Zhou Source Type: research
Pharmacological Considerations during Percutaneous Treatment of Heart Failure
This article aimed to provide a comprehensive review of the role of percutaneous interventions in HF patients, with a primary focus on key features, clinical effectiveness, and safety outcomes. Despite the growing utilization of these interventions, there remain critical gaps in the existing body of evidence. Consequently, the need for high-quality randomized clinical trials and extensive international registries is emphasized to shed light on the specific patient populations and clinical scenarios that stand to benefit most from these innovative devices.PMID:38477207 | DOI:10.2174/0113816128284131240209113009 (Source: Cur...
Source: Current Pharmaceutical Design - March 13, 2024 Category: Drugs & Pharmacology Authors: Jose Antonio Sorolla-Romero Javier Navarrete-Navarro Julia Martinez-Sole Hector M Garcia Garcia Jose Luis Diez-Gil Luis Martinez-Dolz Jorge Sanz-Sanchez Source Type: research
The Potential of Natural Products in the Management of Cardiovascular Disease
Curr Pharm Des. 2024 Feb 20. doi: 10.2174/0113816128295053240207090928. Online ahead of print.ABSTRACTCardiovascular Disease (CVD) is one of the most prevalent diseases in the world, comprising a variety of disorders such as hypertension, heart attacks, Peripheral Vascular Disease (PVD), dyslipidemias, strokes, coronary heart disease, and cardiomyopathies. The World Health Organization (WHO) predicts that 22.2 million people will die from CVD in 2030. Conventional treatments for CVDs are often quite expensive and also have several side effects. This potentiates the use of medicinal plants, which are still a viable alternat...
Source: Current Pharmaceutical Design - March 13, 2024 Category: Drugs & Pharmacology Authors: Harshita Singhai Sunny Rathee Sanjay K Jain Umesh Kumar Patil Source Type: research
Relationship between Compound α-Ketoacid and Microinflammation in Patients with Chronic Kidney Disease
Curr Pharm Des. 2024 Feb 19. doi: 10.2174/0113816128291248240131102709. Online ahead of print.ABSTRACTChronic kidney disease (CKD) refers to the presence of structural or functional abnormalities in the kidneys that affect health, lasting for more than 3 months. CKD is not only the direct cause of global incidence rate and mortality, but also an important risk factor for cardiovascular disease. Persistent microinflammatory state has been recognized as an important component of CKD, which can lead to renal fibrosis and loss of renal function, and plays a crucial role in the pathophysiology and progression of the disease. Si...
Source: Current Pharmaceutical Design - March 13, 2024 Category: Drugs & Pharmacology Authors: Zaobin Chen Yongda Lin Jiali Wang Kaijin Yao Yina Xie Xiutian Chen Tianbiao Zhou Source Type: research
Repurposing of Angiotensin-converting-enzyme Inhibitor on Prevention of Post-surgical Tendon Adhesion
CONCLUSION: Our results showed that ACEI is a safe and effective therapeutic candidate with potent immunomodulatory and anti-fibrotic features to alleviate surgery-induced development of fibrotic adhesive tissue. However, its efficacy needs to be further validated in clinical studies.PMID:38468533 | DOI:10.2174/0113816128284671240214080516 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 12, 2024 Category: Drugs & Pharmacology Authors: Hamideh Naimi Majid Khazaei Fariba Sharifnia Sayyed-Hadi Sayyed-Hosseinian Source Type: research
A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer
This study presented a safer and more economical way of preparing stable SeNPs. The researcher has assessed the antiproliferative efficiency of SeNPs-based paclitaxel delivery systems against tumor cells in vitro with relevant mechanistic visualization. SeNPs stabilized by Pluronic F-127 were synthesized and studied. The significant properties and biological activities of PTX-loaded SeNPs on cancer cells from the lungs, breasts, cervical, and colons. In one study, SeNPs were formulated using chitosan (CTS) polymer and then incorporated into CTS/citrate gel, resulting in a SeNPs-loaded chitosan/citrate complex; in another s...
Source: Current Pharmaceutical Design - March 11, 2024 Category: Drugs & Pharmacology Authors: Rohitas Deshmukh Rajesh Singh Sandeep Sharma Ashwini Kumar Mishra Ranjit K Harwansh Source Type: research
A Snapshot of Selenium-enclosed Nanoparticles for the Management of Cancer
This study presented a safer and more economical way of preparing stable SeNPs. The researcher has assessed the antiproliferative efficiency of SeNPs-based paclitaxel delivery systems against tumor cells in vitro with relevant mechanistic visualization. SeNPs stabilized by Pluronic F-127 were synthesized and studied. The significant properties and biological activities of PTX-loaded SeNPs on cancer cells from the lungs, breasts, cervical, and colons. In one study, SeNPs were formulated using chitosan (CTS) polymer and then incorporated into CTS/citrate gel, resulting in a SeNPs-loaded chitosan/citrate complex; in another s...
Source: Current Pharmaceutical Design - March 11, 2024 Category: Drugs & Pharmacology Authors: Rohitas Deshmukh Rajesh Singh Sandeep Sharma Ashwini Kumar Mishra Ranjit K Harwansh Source Type: research
Challenging Axillary Lymph Nodes on PET/CT in Cancer Patients Throughout COVID-19 Vaccination Era
CONCLUSION: The correct interpretation of images is crucial to avoid unnecessary treatments and invasive procedures in vaccinated cancer pts. A detailed anamnestic interview and the analysis of lymph nodes' CT characteristics, after performing PET/CT, may help to clear any misleading diagnosis.PMID:38454762 | DOI:10.2174/0113816128246329231016091519 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Alessia Giordano Rosj Gallicchio Mariarita Milella Rebecca Storto Anna Nardelli Teresa Pellegrino Antonio Nappi Michele Di Cosola Giovanni Storto Source Type: research
Remedial Dosing Recommendations for Sirolimus Delayed or Missed Dosages Caused by Poor Medication Compliance in Pediatric Tuberous Sclerosis Complex Patients
CONCLUSION: It was the first time to recommend remedial dosages for delayed or missed sirolimus therapy caused by poor medication compliance in pediatric TSC patients based on Monte Carlo simulation. Meanwhile, the present study provided a potential solution for delayed or missed dosages in clinical practice.PMID:38454763 | DOI:10.2174/0113816128299479240213151714 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Yang Yang Lei Jiang Hai-Rong Zhu Wen-Xin Sun Jing-Yu Mao Jing-Wen Miao Yi-Chen Wang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research
Challenging Axillary Lymph Nodes on PET/CT in Cancer Patients Throughout COVID-19 Vaccination Era
CONCLUSION: The correct interpretation of images is crucial to avoid unnecessary treatments and invasive procedures in vaccinated cancer pts. A detailed anamnestic interview and the analysis of lymph nodes' CT characteristics, after performing PET/CT, may help to clear any misleading diagnosis.PMID:38454762 | DOI:10.2174/0113816128246329231016091519 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 8, 2024 Category: Drugs & Pharmacology Authors: Alessia Giordano Rosj Gallicchio Mariarita Milella Rebecca Storto Anna Nardelli Teresa Pellegrino Antonio Nappi Michele Di Cosola Giovanni Storto Source Type: research
