Strategies of targeting KRAS, challenging drug target
Curr Pharm Des. 2022 May 6. doi: 10.2174/1381612828666220506144046. Online ahead of print.ABSTRACTIn the developed world, cancer is the most common cause of death. Among the 36 human genes of the RAS family, KRAS, NRAS, and HRAS play a prominent role in human cancer. KRAS belongs to the Rassuperfamily of proteins and is a small GTPase signal transduction protein. Among the RAS isoform, KRAS is the dominant mutant that induced approximately 86% of the RAS mutations. The most frequently mutated KRAS isoform is KRAS4B, about 90% of pancreatic cancer, 30-40% of colon cancer, and 15 to 20% of lung cancers are caused by mutation...
Source: Current Pharmaceutical Design - May 7, 2022 Category: Drugs & Pharmacology Authors: Abdul Wadood Amar Ajmal Ashfaq Ur Rehman Source Type: research

Novel Insights into the Molecular Mechanisms Involved in the Neuroprotective Effects of C-Phycocyanin Against Brain Ischemia in Rats
CONCLUSION: These results suggest that the inhibition of cerebral NADPH oxidase and the improvement of neuroinflammation are key mechanisms mediating the neuroprotective actions of C-PC against brain ischemia.PMID:35524676 | DOI:10.2174/1381612828666220506145542 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 7, 2022 Category: Drugs & Pharmacology Authors: Javier Mar ín-Prida Jos é Luiz Liberato Alexey Ll ópiz-Arzuaga Karina Stringhetta-Padovani Nancy Pav ón-Fuentes Andr éia Machado Leopoldino Osmany Guirola Cruz Ignacio Hern ández González Mariela Le ón Pérez Antoni Camins Espuny Wagner Ferreira D Source Type: research

Can we succeed in the fight against SARS-CoV-2 with its emerging new variants?
Curr Pharm Des. 2022 May 6. doi: 10.2174/1381612828666220506142117. Online ahead of print.ABSTRACTIn 2019, the whole world came together to confront a life-threatening virus named SARS-CoV-2, which causes COVID-19 illness. The virus infected the human host through the attachment to the ACE2 and CD147 receptors present in some human cells, resulting in cytokine storm and death. The new variants of the virus that caused concern, are Alpha, Beta, Gamma, Delta, and Epsilon based on the WHO label. However, Pango lineages designated them to B.1.1.7, B.1.351, P.1, B.1.617.2, and B.1.429. Variants may be progressively formed in on...
Source: Current Pharmaceutical Design - May 7, 2022 Category: Drugs & Pharmacology Authors: Shima Tavakol Hani Tavakol Mo S Alavijeh Alexander Seifalian Source Type: research

Nucleic acid-conjugated carbohydrate nanobiosensors: A multimodal tool for disease diagnosis
CONCLUSION: NAbCSs provide a real-time monitoring of biosamples qualitatively and semi-quantitatively (luminometer, fluorimeter, etc.) in the absence of trained personnel. Explorations of NAbCSs encompasses advantages in remote resource limited access areas with simultaneous monitoring via smart devices for multiple analytes with greater precision, sensitivity, and selectivity.PMID:35490323 | DOI:10.2174/1381612828666220427140110 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Maithili Kantak Pravin Shende Source Type: research

The role of heat shock protein 27 in carcinogenesis and treatment of colorectal cancer
Curr Pharm Des. 2022 Apr 27. doi: 10.2174/1381612828666220427140640. Online ahead of print.ABSTRACTThe incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of Hsp family. It has attracted particular attention in CRC pathogenesis, since it is involved in fundamental cell functions for cell survival. Evidence show that Hsp27 plays important roles in CRC progression and metastasis. Hsp27...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Fereshteh Asgharzadeh Reyhaneh Moradi-Marjaneh Mahdi Moradi Marjaneh Source Type: research

ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors
Curr Pharm Des. 2022 May 1. doi: 10.2174/1381612828666220501165644. Online ahead of print.ABSTRACTIntegrins are a class of a cell surface adhesion molecule which composed of α subunit (ITGA) and β subunit (ITGB). They belong to heterodimer transmembrane glycoproteins. Its main function in organisms is as the receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9 among integrins. ITGA9 can improve cell migration and regulate various cellular biological functio...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Yinxin Wu Jinlan Chen Fangshun Tan Bei Wang Wen Xu Chengfu Yuan Source Type: research

Nucleic acid-conjugated carbohydrate nanobiosensors: A multimodal tool for disease diagnosis
CONCLUSION: NAbCSs provide a real-time monitoring of biosamples qualitatively and semi-quantitatively (luminometer, fluorimeter, etc.) in the absence of trained personnel. Explorations of NAbCSs encompasses advantages in remote resource limited access areas with simultaneous monitoring via smart devices for multiple analytes with greater precision, sensitivity, and selectivity.PMID:35490323 | DOI:10.2174/1381612828666220427140110 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Maithili Kantak Pravin Shende Source Type: research

The role of heat shock protein 27 in carcinogenesis and treatment of colorectal cancer
Curr Pharm Des. 2022 Apr 27. doi: 10.2174/1381612828666220427140640. Online ahead of print.ABSTRACTThe incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of Hsp family. It has attracted particular attention in CRC pathogenesis, since it is involved in fundamental cell functions for cell survival. Evidence show that Hsp27 plays important roles in CRC progression and metastasis. Hsp27...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Fereshteh Asgharzadeh Reyhaneh Moradi-Marjaneh Mahdi Moradi Marjaneh Source Type: research

ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors
Curr Pharm Des. 2022 May 1. doi: 10.2174/1381612828666220501165644. Online ahead of print.ABSTRACTIntegrins are a class of a cell surface adhesion molecule which composed of α subunit (ITGA) and β subunit (ITGB). They belong to heterodimer transmembrane glycoproteins. Its main function in organisms is as the receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9 among integrins. ITGA9 can improve cell migration and regulate various cellular biological functio...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Yinxin Wu Jinlan Chen Fangshun Tan Bei Wang Wen Xu Chengfu Yuan Source Type: research

Nucleic acid-conjugated carbohydrate nanobiosensors: A multimodal tool for disease diagnosis
CONCLUSION: NAbCSs provide a real-time monitoring of biosamples qualitatively and semi-quantitatively (luminometer, fluorimeter, etc.) in the absence of trained personnel. Explorations of NAbCSs encompasses advantages in remote resource limited access areas with simultaneous monitoring via smart devices for multiple analytes with greater precision, sensitivity, and selectivity.PMID:35490323 | DOI:10.2174/1381612828666220427140110 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Maithili Kantak Pravin Shende Source Type: research

The role of heat shock protein 27 in carcinogenesis and treatment of colorectal cancer
Curr Pharm Des. 2022 Apr 27. doi: 10.2174/1381612828666220427140640. Online ahead of print.ABSTRACTThe incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of Hsp family. It has attracted particular attention in CRC pathogenesis, since it is involved in fundamental cell functions for cell survival. Evidence show that Hsp27 plays important roles in CRC progression and metastasis. Hsp27...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Fereshteh Asgharzadeh Reyhaneh Moradi-Marjaneh Mahdi Moradi Marjaneh Source Type: research

ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors
Curr Pharm Des. 2022 May 1. doi: 10.2174/1381612828666220501165644. Online ahead of print.ABSTRACTIntegrins are a class of a cell surface adhesion molecule which composed of α subunit (ITGA) and β subunit (ITGB). They belong to heterodimer transmembrane glycoproteins. Its main function in organisms is as the receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9 among integrins. ITGA9 can improve cell migration and regulate various cellular biological functio...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Yinxin Wu Jinlan Chen Fangshun Tan Bei Wang Wen Xu Chengfu Yuan Source Type: research

Nucleic acid-conjugated carbohydrate nanobiosensors: A multimodal tool for disease diagnosis
CONCLUSION: NAbCSs provide a real-time monitoring of biosamples qualitatively and semi-quantitatively (luminometer, fluorimeter, etc.) in the absence of trained personnel. Explorations of NAbCSs encompasses advantages in remote resource limited access areas with simultaneous monitoring via smart devices for multiple analytes with greater precision, sensitivity, and selectivity.PMID:35490323 | DOI:10.2174/1381612828666220427140110 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Maithili Kantak Pravin Shende Source Type: research

The role of heat shock protein 27 in carcinogenesis and treatment of colorectal cancer
Curr Pharm Des. 2022 Apr 27. doi: 10.2174/1381612828666220427140640. Online ahead of print.ABSTRACTThe incidence of colorectal cancer (CRC) has significantly increased in recent decades, which has made this disease an important global health issue. Despite many efforts, there is no useful prognostic or diagnostic biomarker for CRC. Heat shock protein 27 (Hsp27) is one of the most studied members of Hsp family. It has attracted particular attention in CRC pathogenesis, since it is involved in fundamental cell functions for cell survival. Evidence show that Hsp27 plays important roles in CRC progression and metastasis. Hsp27...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Fereshteh Asgharzadeh Reyhaneh Moradi-Marjaneh Mahdi Moradi Marjaneh Source Type: research

ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors
Curr Pharm Des. 2022 May 1. doi: 10.2174/1381612828666220501165644. Online ahead of print.ABSTRACTIntegrins are a class of a cell surface adhesion molecule which composed of α subunit (ITGA) and β subunit (ITGB). They belong to heterodimer transmembrane glycoproteins. Its main function in organisms is as the receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9 among integrins. ITGA9 can improve cell migration and regulate various cellular biological functio...
Source: Current Pharmaceutical Design - May 1, 2022 Category: Drugs & Pharmacology Authors: Yinxin Wu Jinlan Chen Fangshun Tan Bei Wang Wen Xu Chengfu Yuan Source Type: research