The Interplay Between Gut Microbiota and Central Nervous System
Curr Pharm Des. 2023 Dec 7. doi: 10.2174/0113816128264312231101110307. Online ahead of print.ABSTRACTThis review highlights the relationships between gastrointestinal microorganisms and the brain. The gut microbiota communicates with the central nervous system through nervous, endocrine, and immune signalling mechanisms. Our brain can modulate the gut microbiota structure and function through the autonomic nervous system, and possibly through neurotransmitters which directly act on bacterial gene expression. In this context, oxidative stress is one the main factors involved in the dysregulation of the gut-brain axis and co...
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Teresa Gervasi Giuseppina Mandalari Source Type: research

Exploration of the Mechanism of Kaempferol in the Treatment of Cervical Cancer-based on Metabolomics and Network Pharmacology
CONCLUSION: This study elucidates the intricate mechanisms by which kaempferol acts against cervical cancer. Furthermore, this research offers a novel approach to investigating the potential pharmacological mechanisms of action exhibited by natural compounds.PMID:38062663 | DOI:10.2174/0113816128268061231012073704 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Dong-Min Cao Tao Liu Source Type: research

The Dosage Recommendation of Cyclosporin in Children with Hemophagocytic Lymphohistiocytosis Based on Population Pharmacokinetic Model
CONCLUSION: It is the first time that the cyclosporin dosage regimens for HLH in children have been developed based on Monte Carlo simulation, and the initial dosage optimizations of cyclosporine in pediatric HLH patients have been recommended.PMID:38062660 | DOI:10.2174/0113816128286290231124055116 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Yang Yang Ya-Feng Li Ke Hu Shi-Jia Zhang Jia-Fang Cui Xue-Ting Huang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research

An In-silico Approach to Design and Validate SiRNA against Monkeypox Virus
CONCLUSION: Thus, the strategy may offer a platform for the development of potential antiviral RNA therapeutics that target MPXV at the genomic level.PMID:38062661 | DOI:10.2174/0113816128275065231103063935 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Kishore Dhotre Anwesha Banerjee Debashree Dass Vijay Nema Anupam Mukherjee Source Type: research

The Interplay Between Gut Microbiota and Central Nervous System
Curr Pharm Des. 2023 Dec 7. doi: 10.2174/0113816128264312231101110307. Online ahead of print.ABSTRACTThis review highlights the relationships between gastrointestinal microorganisms and the brain. The gut microbiota communicates with the central nervous system through nervous, endocrine, and immune signalling mechanisms. Our brain can modulate the gut microbiota structure and function through the autonomic nervous system, and possibly through neurotransmitters which directly act on bacterial gene expression. In this context, oxidative stress is one the main factors involved in the dysregulation of the gut-brain axis and co...
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Teresa Gervasi Giuseppina Mandalari Source Type: research

Exploration of the Mechanism of Kaempferol in the Treatment of Cervical Cancer-based on Metabolomics and Network Pharmacology
CONCLUSION: This study elucidates the intricate mechanisms by which kaempferol acts against cervical cancer. Furthermore, this research offers a novel approach to investigating the potential pharmacological mechanisms of action exhibited by natural compounds.PMID:38062663 | DOI:10.2174/0113816128268061231012073704 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Dong-Min Cao Tao Liu Source Type: research

The Dosage Recommendation of Cyclosporin in Children with Hemophagocytic Lymphohistiocytosis Based on Population Pharmacokinetic Model
CONCLUSION: It is the first time that the cyclosporin dosage regimens for HLH in children have been developed based on Monte Carlo simulation, and the initial dosage optimizations of cyclosporine in pediatric HLH patients have been recommended.PMID:38062660 | DOI:10.2174/0113816128286290231124055116 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Yang Yang Ya-Feng Li Ke Hu Shi-Jia Zhang Jia-Fang Cui Xue-Ting Huang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research

An In-silico Approach to Design and Validate SiRNA against Monkeypox Virus
CONCLUSION: Thus, the strategy may offer a platform for the development of potential antiviral RNA therapeutics that target MPXV at the genomic level.PMID:38062661 | DOI:10.2174/0113816128275065231103063935 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Kishore Dhotre Anwesha Banerjee Debashree Dass Vijay Nema Anupam Mukherjee Source Type: research

The Interplay Between Gut Microbiota and Central Nervous System
Curr Pharm Des. 2023 Dec 7. doi: 10.2174/0113816128264312231101110307. Online ahead of print.ABSTRACTThis review highlights the relationships between gastrointestinal microorganisms and the brain. The gut microbiota communicates with the central nervous system through nervous, endocrine, and immune signalling mechanisms. Our brain can modulate the gut microbiota structure and function through the autonomic nervous system, and possibly through neurotransmitters which directly act on bacterial gene expression. In this context, oxidative stress is one the main factors involved in the dysregulation of the gut-brain axis and co...
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Teresa Gervasi Giuseppina Mandalari Source Type: research

Exploration of the Mechanism of Kaempferol in the Treatment of Cervical Cancer-based on Metabolomics and Network Pharmacology
CONCLUSION: This study elucidates the intricate mechanisms by which kaempferol acts against cervical cancer. Furthermore, this research offers a novel approach to investigating the potential pharmacological mechanisms of action exhibited by natural compounds.PMID:38062663 | DOI:10.2174/0113816128268061231012073704 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Dong-Min Cao Tao Liu Source Type: research

Neuropathy, Its Profile and Experimental Nerve Injury Neuropathic Pain Models: A Review
Curr Pharm Des. 2023 Dec 6. doi: 10.2174/0113816128274200231128065425. Online ahead of print.ABSTRACTNeuropathy is a terrible disorder that has a wide range of etiologies. Drug-induced neuropathy, which happens whenever a chemical agent damages the peripheral nerve system, has been linked here to the iatrogenic creation of some drugs. It is potentially permanent and causes sensory impairments and paresthesia that typically affects the hands, feet, and stockings; motor participation is uncommon. It might appear suddenly or over time, and the long-term outlook varies. The wide range of chronic pain conditions experienced by ...
Source: Current Pharmaceutical Design - December 7, 2023 Category: Drugs & Pharmacology Authors: Krishana Kumar Sharma Nishat Fatima Zeeshan Ali Mohd Moshin Phool Chandra Anurag Verma Omprakash Goshain Gajendra Kumar Source Type: research

CRISPR-Cas9 for the Treatment of Transthyretin Cardiac Amyloidosis
Curr Pharm Des. 2023 Dec 6. doi: 10.2174/0113816128267417231127070901. Online ahead of print.NO ABSTRACTPMID:38058090 | DOI:10.2174/0113816128267417231127070901 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 7, 2023 Category: Drugs & Pharmacology Authors: Giorgia Panichella Alberto Aimo Source Type: research

Neuropathy, Its Profile and Experimental Nerve Injury Neuropathic Pain Models: A Review
Curr Pharm Des. 2023 Dec 6. doi: 10.2174/0113816128274200231128065425. Online ahead of print.ABSTRACTNeuropathy is a terrible disorder that has a wide range of etiologies. Drug-induced neuropathy, which happens whenever a chemical agent damages the peripheral nerve system, has been linked here to the iatrogenic creation of some drugs. It is potentially permanent and causes sensory impairments and paresthesia that typically affects the hands, feet, and stockings; motor participation is uncommon. It might appear suddenly or over time, and the long-term outlook varies. The wide range of chronic pain conditions experienced by ...
Source: Current Pharmaceutical Design - December 7, 2023 Category: Drugs & Pharmacology Authors: Krishana Kumar Sharma Nishat Fatima Zeeshan Ali Mohd Moshin Phool Chandra Anurag Verma Omprakash Goshain Gajendra Kumar Source Type: research

CRISPR-Cas9 for the Treatment of Transthyretin Cardiac Amyloidosis
Curr Pharm Des. 2023 Dec 6. doi: 10.2174/0113816128267417231127070901. Online ahead of print.NO ABSTRACTPMID:38058090 | DOI:10.2174/0113816128267417231127070901 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 7, 2023 Category: Drugs & Pharmacology Authors: Giorgia Panichella Alberto Aimo Source Type: research

Gamma-mangostin Protects S16Y Schwann Cells Against tert-Butyl Hydroperoxide-induced Apoptotic Cell Death
CONCLUSION: Collectively, these findings highlight the ability of γ-mangostin to protect Schwann cells from apoptotic cell death induced by oxidative stress.PMID:38053351 | DOI:10.2174/0113816128270941231124102032 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 6, 2023 Category: Drugs & Pharmacology Authors: Purin Charoensuksai Kwanputtha Arunprasert Audchara Saenkham Praneet Opanasopit Sunit Suksamrarn Pawaris Wongprayoon Source Type: research