The Interplay Between Gut Microbiota and Central Nervous System
Curr Pharm Des. 2023 Dec 7. doi: 10.2174/0113816128264312231101110307. Online ahead of print.ABSTRACTThis review highlights the relationships between gastrointestinal microorganisms and the brain. The gut microbiota communicates with the central nervous system through nervous, endocrine, and immune signalling mechanisms. Our brain can modulate the gut microbiota structure and function through the autonomic nervous system, and possibly through neurotransmitters which directly act on bacterial gene expression. In this context, oxidative stress is one the main factors involved in the dysregulation of the gut-brain axis and co...
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Teresa Gervasi Giuseppina Mandalari Source Type: research
Exploration of the Mechanism of Kaempferol in the Treatment of Cervical Cancer-based on Metabolomics and Network Pharmacology
CONCLUSION: This study elucidates the intricate mechanisms by which kaempferol acts against cervical cancer. Furthermore, this research offers a novel approach to investigating the potential pharmacological mechanisms of action exhibited by natural compounds.PMID:38062663 | DOI:10.2174/0113816128268061231012073704 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Dong-Min Cao Tao Liu Source Type: research
The Dosage Recommendation of Cyclosporin in Children with Hemophagocytic Lymphohistiocytosis Based on Population Pharmacokinetic Model
CONCLUSION: It is the first time that the cyclosporin dosage regimens for HLH in children have been developed based on Monte Carlo simulation, and the initial dosage optimizations of cyclosporine in pediatric HLH patients have been recommended.PMID:38062660 | DOI:10.2174/0113816128286290231124055116 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Yang Yang Ya-Feng Li Ke Hu Shi-Jia Zhang Jia-Fang Cui Xue-Ting Huang Su-Mei He Dong-Dong Wang Xiao Chen Source Type: research
An In-silico Approach to Design and Validate SiRNA against Monkeypox Virus
CONCLUSION: Thus, the strategy may offer a platform for the development of potential antiviral RNA therapeutics that target MPXV at the genomic level.PMID:38062661 | DOI:10.2174/0113816128275065231103063935 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Kishore Dhotre Anwesha Banerjee Debashree Dass Vijay Nema Anupam Mukherjee Source Type: research
The Interplay Between Gut Microbiota and Central Nervous System
Curr Pharm Des. 2023 Dec 7. doi: 10.2174/0113816128264312231101110307. Online ahead of print.ABSTRACTThis review highlights the relationships between gastrointestinal microorganisms and the brain. The gut microbiota communicates with the central nervous system through nervous, endocrine, and immune signalling mechanisms. Our brain can modulate the gut microbiota structure and function through the autonomic nervous system, and possibly through neurotransmitters which directly act on bacterial gene expression. In this context, oxidative stress is one the main factors involved in the dysregulation of the gut-brain axis and co...
Source: Current Pharmaceutical Design - December 8, 2023 Category: Drugs & Pharmacology Authors: Teresa Gervasi Giuseppina Mandalari Source Type: research
