Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates
Curr Pharm Des. 2024 Apr 5. doi: 10.2174/0113816128304230240327044201. Online ahead of print.ABSTRACTInflammation is critical to the formation and development of tumors and is closely associated with cancer. Therefore, addressing inflammation and the mediators that contribute to the inflammatory process may be a useful strategy for both cancer prevention and treatment. Tumor predisposition can be attributed to inflammation. It has been demonstrated that NSAIDs can modify the tumor microenvironment by enhancing apoptosis and chemosensitivity and reducing cell migration. There has been a recent rise in interest in drug repos...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Asmaa E Kassab Ehab M Gedawy Source Type: research
Association of Parity with the Risks of Gestational Diabetes and Macrosomia: A Retrospective Cohort Study in Nanjing, China
CONCLUSION: Parity was not associated with GDM risk, but mildly associated with macrosomia risk. Particular attention should be paid to multiparae with advanced age to reduce the risks of GDM and macrosomia.PMID:38584550 | DOI:10.2174/0113816128294311240322041144 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Shijie Geng Junya Wang Zhi Geng Juan Wen Source Type: research
Elucidation of the Molecular Mechanism of Compound Danshen Dripping Pills Against Angina Pectoris based on Network Pharmacology and Molecular Docking
CONCLUSION: This study comprehensively illustrated the bioactive, potential targets, and molecular mechanisms of CDDP against AP, offering fresh perspectives into the molecular mechanisms of CDDP in preventing and treating AP.PMID:38584551 | DOI:10.2174/0113816128287109240321074628 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Xiaocui Tian Shiqi Yin Zhiguang Liu Jinglin Cao Xinyu Liu Qi Qiu Source Type: research
CRISPR and Gene Editing: A Game-Changer in Drug Development
Curr Pharm Des. 2024 Apr 4. doi: 10.2174/0113816128298080240328053845. Online ahead of print.ABSTRACTCRISPR and gene editing technologies have emerged as transformative tools in medicine, offering unprecedented precision in targeting genetic disorders and revolutionizing drug development. This review explores the multifaceted impact of CRISPR across various medical domains, from hereditary diseases to infectious diseases and cancer. The potential of CRISPR in personalized medicine, therapeutic innovation, and pandemic prevention is highlighted, along with its role in reshaping traditional drug development processes. Howeve...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Tarun Sharma Ankit Awasthi Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
Neuropilin-1 Binding Peptide as Fusion to Diphtheria Toxin Induces Apoptosis in Non-small Cell Lung Cancer Cell Line
CONCLUSION: Taken together, DTA-triCRGDK is a promising tool for targeted therapy of NRP-1 overexpressing cancer cells.PMID:38584554 | DOI:10.2174/0113816128292382240325074032 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Sara Eghtedari Mahdi Behdani Fatemeh Kazemi-Lomedasht Source Type: research
A Comprehensive Guide to the Development, Evaluation, and Future Prospects of Self-nanoemulsifying Drug Delivery Systems for Poorly Water-soluble Drugs
Curr Pharm Des. 2024 Apr 5. doi: 10.2174/0113816128296705240327065131. Online ahead of print.ABSTRACTSelf-Nano Emulsifying Drug Delivery Systems (SNEDDS) are novel formulations that can enhance the solubility and bioavailability of poorly water-soluble drugs. SNEDDS are composed of lipids, surfactants, co-solvents, and drugs and can spontaneously form nanoemulsions when mixed with water under mild agitation. SNEDDS can be formulated as liquid or solid dosage forms and can improve drug absorption by increasing the interfacial area, protecting the drug from degradation, and facilitating lymphatic transport. SNEDDS is charact...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Abhishek Chauhan Raj Kamal Ritika Mishra Devank Shekho Ankit Awasthi Source Type: research
Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates
Curr Pharm Des. 2024 Apr 5. doi: 10.2174/0113816128304230240327044201. Online ahead of print.ABSTRACTInflammation is critical to the formation and development of tumors and is closely associated with cancer. Therefore, addressing inflammation and the mediators that contribute to the inflammatory process may be a useful strategy for both cancer prevention and treatment. Tumor predisposition can be attributed to inflammation. It has been demonstrated that NSAIDs can modify the tumor microenvironment by enhancing apoptosis and chemosensitivity and reducing cell migration. There has been a recent rise in interest in drug repos...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Asmaa E Kassab Ehab M Gedawy Source Type: research
Association of Parity with the Risks of Gestational Diabetes and Macrosomia: A Retrospective Cohort Study in Nanjing, China
CONCLUSION: Parity was not associated with GDM risk, but mildly associated with macrosomia risk. Particular attention should be paid to multiparae with advanced age to reduce the risks of GDM and macrosomia.PMID:38584550 | DOI:10.2174/0113816128294311240322041144 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Shijie Geng Junya Wang Zhi Geng Juan Wen Source Type: research
Elucidation of the Molecular Mechanism of Compound Danshen Dripping Pills Against Angina Pectoris based on Network Pharmacology and Molecular Docking
CONCLUSION: This study comprehensively illustrated the bioactive, potential targets, and molecular mechanisms of CDDP against AP, offering fresh perspectives into the molecular mechanisms of CDDP in preventing and treating AP.PMID:38584551 | DOI:10.2174/0113816128287109240321074628 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Xiaocui Tian Shiqi Yin Zhiguang Liu Jinglin Cao Xinyu Liu Qi Qiu Source Type: research
CRISPR and Gene Editing: A Game-Changer in Drug Development
Curr Pharm Des. 2024 Apr 4. doi: 10.2174/0113816128298080240328053845. Online ahead of print.ABSTRACTCRISPR and gene editing technologies have emerged as transformative tools in medicine, offering unprecedented precision in targeting genetic disorders and revolutionizing drug development. This review explores the multifaceted impact of CRISPR across various medical domains, from hereditary diseases to infectious diseases and cancer. The potential of CRISPR in personalized medicine, therapeutic innovation, and pandemic prevention is highlighted, along with its role in reshaping traditional drug development processes. Howeve...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Tarun Sharma Ankit Awasthi Source Type: research
Celastrol Elicits Antitumor Effects through Inducing Immunogenic Cell Death and Downregulating PD-L1 in ccRCC
CONCLUSION: These findings indicate that CeT not only induces ICD but also suppresses PD-L1 by down-regulating MAPK1 expression, which will provide an attractive strategy for ccRCC immunotherapy.PMID:38584553 | DOI:10.2174/0113816128288970240321073436 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Hong-Fang Li Neng Zhu Jia-Jun Wu Ya-Ning Shi Jia Gu Li Qin Source Type: research
Neuropilin-1 Binding Peptide as Fusion to Diphtheria Toxin Induces Apoptosis in Non-small Cell Lung Cancer Cell Line
CONCLUSION: Taken together, DTA-triCRGDK is a promising tool for targeted therapy of NRP-1 overexpressing cancer cells.PMID:38584554 | DOI:10.2174/0113816128292382240325074032 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Sara Eghtedari Mahdi Behdani Fatemeh Kazemi-Lomedasht Source Type: research
A Comprehensive Guide to the Development, Evaluation, and Future Prospects of Self-nanoemulsifying Drug Delivery Systems for Poorly Water-soluble Drugs
Curr Pharm Des. 2024 Apr 5. doi: 10.2174/0113816128296705240327065131. Online ahead of print.ABSTRACTSelf-Nano Emulsifying Drug Delivery Systems (SNEDDS) are novel formulations that can enhance the solubility and bioavailability of poorly water-soluble drugs. SNEDDS are composed of lipids, surfactants, co-solvents, and drugs and can spontaneously form nanoemulsions when mixed with water under mild agitation. SNEDDS can be formulated as liquid or solid dosage forms and can improve drug absorption by increasing the interfacial area, protecting the drug from degradation, and facilitating lymphatic transport. SNEDDS is charact...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Abhishek Chauhan Raj Kamal Ritika Mishra Devank Shekho Ankit Awasthi Source Type: research
Recent Advancements in Refashioning of NSAIDs and their Derivatives as Anticancer Candidates
Curr Pharm Des. 2024 Apr 5. doi: 10.2174/0113816128304230240327044201. Online ahead of print.ABSTRACTInflammation is critical to the formation and development of tumors and is closely associated with cancer. Therefore, addressing inflammation and the mediators that contribute to the inflammatory process may be a useful strategy for both cancer prevention and treatment. Tumor predisposition can be attributed to inflammation. It has been demonstrated that NSAIDs can modify the tumor microenvironment by enhancing apoptosis and chemosensitivity and reducing cell migration. There has been a recent rise in interest in drug repos...
Source: Current Pharmaceutical Design - April 8, 2024 Category: Drugs & Pharmacology Authors: Asmaa E Kassab Ehab M Gedawy Source Type: research
