Free Radicals, Mitochondrial Dysfunction and Sepsis-induced Organ Dysfunction: A Mechanistic Insight
Curr Pharm Des. 2024 Jan 18. doi: 10.2174/0113816128279655231228055842. Online ahead of print.ABSTRACTSepsis is a complex clinical condition and a leading cause of death worldwide. During Sepsis, there is a derailment in the host response to infection, which can progress to severe sepsis and multiple organ dysfunction or failure, which leads to death. Free radicals, including reactive oxygen species (ROS) generated predominantly in mitochondria, are one of the key players in impairing normal organ function in sepsis. ROS contributing to oxidative stress has been reported to be the main culprit in the injury of the lung, he...
Source: Current Pharmaceutical Design - January 20, 2024 Category: Drugs & Pharmacology Authors: Sanni Kumar Vijay Kumar Srivastava Sanket Kaushik Juhi Saxena Anupam Jyoti Source Type: research
Deciphering Multi-target Pharmacological Mechanism of Cucurbita pepo Seeds against Kidney Stones: Network Pharmacology and Molecular Docking Approach
CONCLUSION: These findings provide insight into the anti-kidney stone effects of Cucurbita pepo at a molecular level. In conclusion, this study contributes to understanding the potential of Cucurbita pepo in combating kidney stones and lays the foundation for further research.PMID:38213175 | DOI:10.2174/0113816128271781231104151155 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 12, 2024 Category: Drugs & Pharmacology Authors: Aqsa Shahzadi Usman Ali Ashfaq Mohsin Khurshid Muhammad Atif Nisar Asad Syed Ali H Bahkali Source Type: research
Novel Arena of Nanocosmetics: Applications and their Remarkable Contribution in the Management of Dermal Disorders, Topical Delivery, Future Trends and Challenges
Curr Pharm Des. 2024 Jan 10. doi: 10.2174/0113816128288516231228101024. Online ahead of print.ABSTRACTNanocosmetics have attracted a considerable audience towards natural care due to their low cost, target-specific delivery, and reduced toxicity compared to chemical-based cosmetics. Nanofomulations, including nanoemulsions, nanotubes, and polymeric carriers, have become next-generation products explored for the multifaced applications of nanotechnology in skin care. The rise in the cosmetic industry demands innovative and personalized products designed using nanocarriers for better targeting and improving patient complianc...
Source: Current Pharmaceutical Design - January 11, 2024 Category: Drugs & Pharmacology Authors: Ashima Ahuja Meenakshi Bajpai Source Type: research
Carbon Nanotubes for Targeted Therapy: Safety, Efficacy, Feasibility and Regulatory Aspects
Curr Pharm Des. 2024 Jan 5. doi: 10.2174/0113816128282085231226065407. Online ahead of print.ABSTRACTIt is crucial that novel and efficient drug delivery techniques be created in order to improve the pharmacological profiles of a wide variety of classes of medicinal compounds. Carbon nanotubes (CNTs) have recently come to the forefront as an innovative and very effective technique for transporting and translocating medicinal compounds. CNTs were suggested and aggressively researched as multifunctional novel transporters designed for targeted pharmaceutical distribution and used in diagnosis. CNTs can act as vectors for dir...
Source: Current Pharmaceutical Design - January 8, 2024 Category: Drugs & Pharmacology Authors: Babita Gupta Pramod Kumar Sharma Rishabha Malviya Source Type: research
Carbon Nanotubes for Targeted Therapy: Safety, Efficacy, Feasibility and Regulatory Aspects
Curr Pharm Des. 2024 Jan 5. doi: 10.2174/0113816128282085231226065407. Online ahead of print.ABSTRACTIt is crucial that novel and efficient drug delivery techniques be created in order to improve the pharmacological profiles of a wide variety of classes of medicinal compounds. Carbon nanotubes (CNTs) have recently come to the forefront as an innovative and very effective technique for transporting and translocating medicinal compounds. CNTs were suggested and aggressively researched as multifunctional novel transporters designed for targeted pharmaceutical distribution and used in diagnosis. CNTs can act as vectors for dir...
Source: Current Pharmaceutical Design - January 8, 2024 Category: Drugs & Pharmacology Authors: Babita Gupta Pramod Kumar Sharma Rishabha Malviya Source Type: research
Role of Amphotericin B in the Treatment of Mucormycosis
CONCLUSION: The article demonstrates the traits of the drug associated with its chemical, pharmacokinetics, stability, and other features, and illustrates their most useful characteristics for clinical application.PMID:38178658 | DOI:10.2174/0113816128272443231221101415 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 5, 2024 Category: Drugs & Pharmacology Authors: Alisha Sachdeva Monika Targhotra Meenakshi Kanwar Chauhan Monica Chopra Source Type: research
Role of Amphotericin B in the Treatment of Mucormycosis
CONCLUSION: The article demonstrates the traits of the drug associated with its chemical, pharmacokinetics, stability, and other features, and illustrates their most useful characteristics for clinical application.PMID:38178658 | DOI:10.2174/0113816128272443231221101415 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 5, 2024 Category: Drugs & Pharmacology Authors: Alisha Sachdeva Monika Targhotra Meenakshi Kanwar Chauhan Monica Chopra Source Type: research
Role of Amphotericin B in the Treatment of Mucormycosis
CONCLUSION: The article demonstrates the traits of the drug associated with its chemical, pharmacokinetics, stability, and other features, and illustrates their most useful characteristics for clinical application.PMID:38178658 | DOI:10.2174/0113816128272443231221101415 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 5, 2024 Category: Drugs & Pharmacology Authors: Alisha Sachdeva Monika Targhotra Meenakshi Kanwar Chauhan Monica Chopra Source Type: research
Poly(lactic-co-glycolic) Acid (PLGA) Nanoparticles and Transdermal Drug Delivery: An Overview
CONCLUSION: PLGA nanoparticles can be considered efficient nanocarriers for the transdermal delivery of drugs. Nevertheless, the clinical investigation of PLGA nanoparticles for the transdermal administration of therapeutic agents remains a formidable obstacle.PMID:38173050 | DOI:10.2174/0113816128275385231027054743 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 4, 2024 Category: Drugs & Pharmacology Authors: Lalit Kumar Gauree Kukreti Ritesh Rana Himanshu Chaurasia Anchal Sharma Neelam Sharma None Komal Source Type: research
Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic Actions and Synergistic Anticancer Efficacy
Conclusion: This article sheds light on HST structure-function correlation and pleiotropic anticancer mechanisms, in unaided and NC-administered delivery in singular and with CDs synergy. The discussion could streamline the HST usefulness and long-term anticancer efficacy.PMID:38173051 | DOI:10.2174/0113816128253609231030070414 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 4, 2024 Category: Drugs & Pharmacology Authors: Parth Malik Manju Bernela Mahima Seth Priya Kaushal Tapan Kumar Mukherjee Source Type: research
Multiphasic Gels: Achieving New Drug Delivery
Curr Pharm Des. 2023;29(40):3171. doi: 10.2174/138161282940231220112709.NO ABSTRACTPMID:38173055 | DOI:10.2174/138161282940231220112709 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 4, 2024 Category: Drugs & Pharmacology Authors: Manisha Pandey Shubhini A Saraf Shailendra K Saraf Source Type: research
Poly(lactic-co-glycolic) Acid (PLGA) Nanoparticles and Transdermal Drug Delivery: An Overview
CONCLUSION: PLGA nanoparticles can be considered efficient nanocarriers for the transdermal delivery of drugs. Nevertheless, the clinical investigation of PLGA nanoparticles for the transdermal administration of therapeutic agents remains a formidable obstacle.PMID:38173050 | DOI:10.2174/0113816128275385231027054743 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 4, 2024 Category: Drugs & Pharmacology Authors: Lalit Kumar Gauree Kukreti Ritesh Rana Himanshu Chaurasia Anchal Sharma Neelam Sharma None Komal Source Type: research
Recent Progress in the Hesperetin Delivery Regimes: Significance of Pleiotropic Actions and Synergistic Anticancer Efficacy
Conclusion: This article sheds light on HST structure-function correlation and pleiotropic anticancer mechanisms, in unaided and NC-administered delivery in singular and with CDs synergy. The discussion could streamline the HST usefulness and long-term anticancer efficacy.PMID:38173051 | DOI:10.2174/0113816128253609231030070414 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 4, 2024 Category: Drugs & Pharmacology Authors: Parth Malik Manju Bernela Mahima Seth Priya Kaushal Tapan Kumar Mukherjee Source Type: research
Multiphasic Gels: Achieving New Drug Delivery
Curr Pharm Des. 2023;29(40):3171. doi: 10.2174/138161282940231220112709.NO ABSTRACTPMID:38173055 | DOI:10.2174/138161282940231220112709 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 4, 2024 Category: Drugs & Pharmacology Authors: Manisha Pandey Shubhini A Saraf Shailendra K Saraf Source Type: research
GDF-10 Induces an Inhibitory Effect on Epithelial-Mesenchymal Transition of Laryngeal Cancer via LPR4
CONCLUSION: Our findings support that GDF-10 can inhibit the proliferation, migration, and invasion, and promote apoptosis of laryngeal carcinoma AMC-HN-8 cells. GDF-10 inhibits the EMT of laryngeal carcinoma through LRP4 and thus inhibits the progression of laryngeal carcinoma.PMID:38163971 | DOI:10.2174/0113816128261029231206035206 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - January 2, 2024 Category: Drugs & Pharmacology Authors: Xuan Kan Li Ai Ruidi Guan Jianwei Hao Yanan Sun Wei Xiu Source Type: research
