Survival of Patients with Primary Brain Tumor: A Data Analysis of 10 Years
CONCLUSION: This study draws attention to the variations in the median survival times of the various kinds of primary brain tumors, with oligodendroglioma having the longest median survival time (199 months, or approximately 16.6 years) and glioblastoma having the shortest (8 months).PMID:38571355 | DOI:10.2174/0113816128306113240328050608 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 4, 2024 Category: Drugs & Pharmacology Authors: Shristy Verma Rishabha Malviya Prerna Uniyal Source Type: research
Mechanism Research of PZD Inhibiting Lung Cancer Cell Proliferation, Invasion, and Migration Based on Network Pharmacology
CONCLUSION: PZD could inhibit the cell proliferation, migration, and invasion of NCI-H1299 cells partially through the PI3K/AKT signaling pathway. These findings suggested that PZD might be a potential treatment strategy for lung cancer patients.PMID:38571356 | DOI:10.2174/0113816128296328240329032332 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 4, 2024 Category: Drugs & Pharmacology Authors: Fan Feng Ping Hu Lei Peng Jun Chen Xingkui Tao Source Type: research
Why have SGLT2 Inhibitors Failed to Achieve the Desired Success in COVID-19?
This article aims to uncover the reasons for the confusion in the literature and to unravel why SGLT2i failed to succeed in COVID-19 based on some solid evidence as well as speculative and personal perspectives.PMID:38566383 | DOI:10.2174/0113816128300162240322075423 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 3, 2024 Category: Drugs & Pharmacology Authors: Medine Cumhur Cure Erkan Cure Source Type: research
Why have SGLT2 Inhibitors Failed to Achieve the Desired Success in COVID-19?
This article aims to uncover the reasons for the confusion in the literature and to unravel why SGLT2i failed to succeed in COVID-19 based on some solid evidence as well as speculative and personal perspectives.PMID:38566383 | DOI:10.2174/0113816128300162240322075423 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 3, 2024 Category: Drugs & Pharmacology Authors: Medine Cumhur Cure Erkan Cure Source Type: research
Zamzam Water Mitigates Cardiac Toxicity Risk through Modulation of GUT Microbiota and the Renin-angiotensin System
CONCLUSION: Zam treatment mitigated cardiac toxicity risk through the modulation of GUT microbiota and the renin-angiotensin system and tissue histology effectively.PMID:38561612 | DOI:10.2174/0113816128302001240321044409 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 1, 2024 Category: Drugs & Pharmacology Authors: Ryan Adnan Sheikh Mohammad Shahid Nadeem Turky Omar Asar Mohammed A Almujtaba Salma Naqvi Fahad A Alabassi Naif A R Almalki Vikas Kumar Firoz Anwar Source Type: research
Molecular Mechanisms of Medicinal Plant Securinega Suffruticosa-derived Compound Securinine against Spinal Muscular Atrophy based on Network Pharmacology and Experimental Verification
CONCLUSION: Securinine might alleviate SMA by elevating HDAC1 and PRMT5 expression and reducing PTGS2 via JAK2-STAT3 suppression and PI3K-Akt activation.PMID:38561613 | DOI:10.2174/0113816128288504240321041408 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 1, 2024 Category: Drugs & Pharmacology Authors: Yinhong Zhang Jing He Lifeng Xiang Xinhua Tang Shiyu Wang Aoyu Li Chaoyan Wang Li Li Baosheng Zhu Source Type: research
Zamzam Water Mitigates Cardiac Toxicity Risk through Modulation of GUT Microbiota and the Renin-angiotensin System
CONCLUSION: Zam treatment mitigated cardiac toxicity risk through the modulation of GUT microbiota and the renin-angiotensin system and tissue histology effectively.PMID:38561612 | DOI:10.2174/0113816128302001240321044409 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 1, 2024 Category: Drugs & Pharmacology Authors: Ryan Adnan Sheikh Mohammad Shahid Nadeem Turky Omar Asar Mohammed A Almujtaba Salma Naqvi Fahad A Alabassi Naif A R Almalki Vikas Kumar Firoz Anwar Source Type: research
Molecular Mechanisms of Medicinal Plant Securinega Suffruticosa-derived Compound Securinine against Spinal Muscular Atrophy based on Network Pharmacology and Experimental Verification
CONCLUSION: Securinine might alleviate SMA by elevating HDAC1 and PRMT5 expression and reducing PTGS2 via JAK2-STAT3 suppression and PI3K-Akt activation.PMID:38561613 | DOI:10.2174/0113816128288504240321041408 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 1, 2024 Category: Drugs & Pharmacology Authors: Yinhong Zhang Jing He Lifeng Xiang Xinhua Tang Shiyu Wang Aoyu Li Chaoyan Wang Li Li Baosheng Zhu Source Type: research
Cellular and Mitochondrial Pathways Contribute to SGLT2 Inhibitors-mediated Tissue Protection: Experimental and Clinical Data
In conclusion, like a treasure chest brimming with untold riches, the influence of SGLT2i on mitochondrial function holds untold potential for cardiovascular health. Unlocking these secrets, like a map guiding adventurers to hidden riches, promises to pave the way for even more potent therapeutic strategies.PMID:38551044 | DOI:10.2174/0113816128289350240320063045 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Ra úl Lelio Sanz Sebasti án García Menéndez Felipe Inserra Le ón Ferder Walter Manucha Source Type: research
Studies in Solid Solution Formation between Acetaminophen and Povidone and Mouth mouth-dissolving Strip Formulation
CONCLUSION: The developed SS can also be formulated as tablets, capsules, and oral dissolving tablets to deliver adult doses with improved therapeutic benefits and patient compliance.PMID:38551045 | DOI:10.2174/0113816128297499240321034304 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Aliasgar Shahiwala Source Type: research
Innovative Strategies to Enhance mRNA Vaccine Delivery and Effectiveness: Mechanisms and Future Outlook
Curr Pharm Des. 2024 Mar 28. doi: 10.2174/0113816128296588240321072042. Online ahead of print.ABSTRACTThe creation of mRNA vaccines has transformed the area of vaccination and allowed for the production of COVID-19 vaccines with previously unheard-of speed and effectiveness. The development of novel strategies to enhance the delivery and efficiency of mRNA vaccines has been motivated by the ongoing constraints of the present mRNA vaccine delivery systems. In this context, intriguing methods to get beyond these restrictions include lipid nanoparticles, self-amplifying RNA, electroporation, microneedles, and cell-targeted ad...
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Ankit Awasthi Source Type: research
Design of Nanodrug Delivery Systems for Tumor Bone Metastasis
Curr Pharm Des. 2024 Mar 27. doi: 10.2174/0113816128296883240320040636. Online ahead of print.ABSTRACTTumor metastasis is a complex process that is controlled at the molecular level by numerous cytokines. Primary breast and prostate tumors most commonly metastasize to bone, and the development of increasingly accurate targeted nanocarrier systems has become a research focus for more effective anti-bone metastasis therapy. This review summarizes the molecular mechanisms of bone metastasis and the principles and methods for designing bone-targeted nanocarriers and then provides an in-depth review of bone-targeted nanocarrier...
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Xiaoqing Zhai Shan Peng Chunyuan Zhai Shuai Wang Meina Xie Shoudong Guo Jingkun Bai Source Type: research
Cellular and Mitochondrial Pathways Contribute to SGLT2 Inhibitors-mediated Tissue Protection: Experimental and Clinical Data
In conclusion, like a treasure chest brimming with untold riches, the influence of SGLT2i on mitochondrial function holds untold potential for cardiovascular health. Unlocking these secrets, like a map guiding adventurers to hidden riches, promises to pave the way for even more potent therapeutic strategies.PMID:38551044 | DOI:10.2174/0113816128289350240320063045 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Ra úl Lelio Sanz Sebasti án García Menéndez Felipe Inserra Le ón Ferder Walter Manucha Source Type: research
Studies in Solid Solution Formation between Acetaminophen and Povidone and Mouth mouth-dissolving Strip Formulation
CONCLUSION: The developed SS can also be formulated as tablets, capsules, and oral dissolving tablets to deliver adult doses with improved therapeutic benefits and patient compliance.PMID:38551045 | DOI:10.2174/0113816128297499240321034304 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Aliasgar Shahiwala Source Type: research
Innovative Strategies to Enhance mRNA Vaccine Delivery and Effectiveness: Mechanisms and Future Outlook
Curr Pharm Des. 2024 Mar 28. doi: 10.2174/0113816128296588240321072042. Online ahead of print.ABSTRACTThe creation of mRNA vaccines has transformed the area of vaccination and allowed for the production of COVID-19 vaccines with previously unheard-of speed and effectiveness. The development of novel strategies to enhance the delivery and efficiency of mRNA vaccines has been motivated by the ongoing constraints of the present mRNA vaccine delivery systems. In this context, intriguing methods to get beyond these restrictions include lipid nanoparticles, self-amplifying RNA, electroporation, microneedles, and cell-targeted ad...
Source: Current Pharmaceutical Design - March 29, 2024 Category: Drugs & Pharmacology Authors: Abhishek Verma Ankit Awasthi Source Type: research
