Molecular Mechanisms of Medicinal Plant Securinega Suffruticosa-derived Compound Securinine against Spinal Muscular Atrophy based on Network Pharmacology and Experimental Verification

CONCLUSION: Securinine might alleviate SMA by elevating HDAC1 and PRMT5 expression and reducing PTGS2 via JAK2-STAT3 suppression and PI3K-Akt activation.PMID:38561613 | DOI:10.2174/0113816128288504240321041408

Source: Current Pharmaceutical Design - April 1, 2024 Category: Drugs & Pharmacology Authors: Yinhong Zhang Jing He Lifeng Xiang Xinhua Tang Shiyu Wang Aoyu Li Chaoyan Wang Li Li Baosheng Zhu Source Type: research