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Randomized trial of preoperative administration of oral pregabalin for postoperative analgesia in patients scheduled for radiofrequency ablation of focal lesions in the liver.
Authors: Abdelfattah AAM, Rizk F, Hawash N, Hanafy A, El-Kalla F, Abd-Elsalam S Abstract PURPOSE: The aim of this study was to evaluate the effect of preoperative pregabalin on postoperative analgesia in patients undergoing radiofrequency ablation (RFA) of hepatic focal lesions (HFLs). METHODS: This randomized controlled study was carried out on 70 adult patients for whom RFA was indicated to treat hepatocellular carcinoma. They were randomized into two groups: Group I: 35 patients who were given a placebo before the procedure and Group II: 35 patients who were given 150 mg of oral pregabalin one hour be...
Source: International Journal of Hyperthermia - January 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Percutaneous radiofrequency ablation of painful spinal metastasis: a systematic literature assessment of analgesia and safety.
CONCLUSION: RFA, combined with vertebral augmentation in most of the cases, is effective and safe in achieving short to mid-term (from 1 week to 6 months) analgesia in patients affected by painful spinal metastasis. PMID: 29308694 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Real-time estimation of lesion depth and control of radiofrequency ablation within ex vivo animal tissues using a neural network.
CONCLUSIONS: The results show that a NN could make lesion depth estimations in real-time using less in situ devices than current techniques. With the NN-based technique, physicians could deliver quicker and more precise ablation therapy. PMID: 29301446 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Effects of a microbubble ultrasound contrast agent on high-intensity focused ultrasound for uterine fibroids: a randomised controlled trial.
CONCLUSIONS: SonoVue could be safely used to enhance the ablation effects of HIFU treatment of uterine fibroids. PMID: 29301450 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Evaluation and selection of anatomic sites for magnetic resonance imaging-guided mild hyperthermia therapy: a healthy volunteer study.
This study evaluated the precision and accuracy of MR thermometry in healthy volunteers at different anatomical sites for long scan times. METHODS: A proton resonance frequency shift method was used for MR thermometry. Eight volunteers were subjected to a 5-min scanning protocol, targeting chest wall, bladder wall, and leg muscles. Six volunteers were subjected to a 30-min scanning protocol and three volunteers were subjected to a 60-min scanning protocol, both targeting the leg muscles. The precision and accuracy of the MR thermometry were quantified. Both the mean precision and accuracy
Source: International Journal of Hyperthermia - January 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Sonographic measurement of thyroid nodule changes after microwave ablation: relationship between multiple parameters.
CONCLUSIONS: Long-term follow-up emphasises changes in the shape and spatial structure of complex benign thyroid nodules, rather than size variations, after effective MWA. Index R, which is the surface area to volume ratio, can also reflect the shape change to some degree. PMID: 29303011 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

LncRNA FUNDC2P4 down-regulation promotes epithelial-mesenchymal transition by reducing E-cadherin expression in residual hepatocellular carcinoma after insufficient radiofrequency ablation.
CONCLUSIONS: We explored that lncRNA FUNDC2P4 down-regulation promoted EMT leading to tumor proliferation, invasion and migration by reducing E-cadherin expression in residual HCC after insufficient RFA in vitro. These results suggest that FUNDC2P4 may have potentially therapeutic value for prevention and treatment of HCC recurrence after RFA in the future. PMID: 29295626 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 5, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The effect of modulated electro-hyperthermia on temperature and blood flow in human cervical carcinoma.
CONCLUSION: Regional heating of the pelvic area with mEHT significantly increased the peri-tumor temperature and improved the blood flow in cervical cancer. This is the first demonstration that the blood flow in cervical cancer is increased by regional hyperthermia. Such increases in temperature and blood flow may account for the clinical observations that hyperthermia improves the response of cervical cancer to radiotherapy or chemotherapy. PMID: 29297234 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 5, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Residual tumor less than 0,25 centimetres and positive lymph nodes are risk factors for early relapse in recurrent ovarian peritoneal carcinomatosis treated with cytoreductive surgery, HIPEC and systemic chemotherapy.
CONCLUSIONS: The combination of both (CC1 and positive lymph nodes) makes that the indication of CRS and HIPEC should be individualized. However, the major morbidity, stage IV and the time to the adjuvant treatment were not associated with an early recurrence, so that, a major aggressiveness is recommended to achieve a CC0. PMID: 29298538 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 5, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Drug release kinetics of temperature sensitive liposomes measured at high-temporal resolution with a millifluidic device.
CONCLUSIONS: The millifluidic device allows measurement of TSL release at unprecedented temporal resolution, thus allowing adequate characterisation of TSL release at time scales relevant for intravascular triggered drug release. The type of buffer and encapsulated compound significantly affect release kinetics and need to be considered when designing and evaluating novel TSL-drug combinations. PMID: 29284329 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - December 31, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A retrospective study of ultrasound-guided high intensity focused ultrasound ablation for multiple uterine fibroids in South Africa.
CONCLUSION: Based on our results, USgHIFU is safe and effective in treating patients with multiple uterine fibroids. PMID: 29278943 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - December 29, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Elastin-Like Polypeptide incorporated thermally sensitive liposome improve antibiotic therapy against Staphyloccous aureus in vitro.
Authors: Nigatu AS, Ashar H, Sethuraman SN, Wardlow R, Maples D, Malayer J, Ranjan A Abstract Musculoskeletal infections caused by bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa in children and adults can lead to adverse outcomes including a need for extensive surgical debridement and limb amputation. To enable targeted antimicrobial release in infected tissues, the objective of this study was to design and investigate novel Elastin-Like Polypeptide (ELP) based thermally-sensitive liposomes in vitro. ELP biopolymers can change their phase behavior at higher temperatures. We hypothesized that ELP-...
Source: International Journal of Hyperthermia - December 29, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Experimental assessment of phase aberration correction for breast MRgFUS therapy.
This study validates that phase aberrations in breast magnetic resonance-guided focused ultrasound (MRgFUS) therapies can be corrected in a clinically relevant time frame to generate more intense, smaller and more spatially accurate foci. MATERIALS AND METHODS: Hybrid Angular Spectrum (HAS) ultrasound calculations in an MRI-based tissue model were used to compute phase aberration corrections for improved experimental MRgFUS heating in four heterogeneous breast-mimicking phantoms (N = 18 total locations). MR temperature imaging was used to evaluate the maximum temperature rise, focus volume, and focus accu...
Source: International Journal of Hyperthermia - December 29, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Adjuvant intraperitoneal chemotherapy for the treatment of colorectal cancer at risk for peritoneal carcinomatosis: a systematic review.
CONCLUSIONS: This systematic review supports the use of adjuvant IP chemotherapy in resectable colorectal cancer at risk for peritoneal spread. Future trials should seek to standardise inclusion criteria and IP chemotherapy modalities to better define the role of this treatment in patients with resectable colorectal cancer. PMID: 29214884 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - December 9, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Percutaneous microwave ablation of renal cell carcinoma using a high power microwave system: focus upon safety and efficacy.
CONCLUSIONS: Percutaneous microwave ablation of RCC using a high power microwave system is a safe and efficacious technique for the treatment of small- to medium-sized renal masses. PMID: 29202667 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - December 6, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Intravesical radiofrequency induced hyperthermia enhances mitomycin C accumulation in tumour tissue.
CONCLUSION: Intravesical RF-CHT results in higher tumour MMC concentrations vs. cold MMC instillation which contributes to its superior efficacy. PMID: 29191126 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - December 2, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Application of dynamic thermal imaging in a photocarcinogenesis mouse model.
CONCLUSIONS Dynamic thermal imaging is useful to differentiate normal, premalignant, and malignant cutaneous lesions. Increased vasculature is the key change responsible for different thermal imaging results. PMID: 29166797 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - November 25, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review.
CONCLUSIONS: Hyperthermia, when added to chemotherapy and/or radiotherapy, may positively affect treatment outcome for patients with pancreatic cancer. However, the quality of the reviewed studies was limited and future randomised controlled trials are needed to establish efficacy. PMID: 29168401 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - November 25, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided percutaneous microwave ablation vs. surgical resection for thoracoabdominal wall implants from hepatocellular carcinoma: intermediate-term results.
Authors: An C, Hu ZL, Liang P, Cheng ZG, Han ZY, Yu J, Liu FY Abstract OBJECTIVE: The aims of this study were to compare the clinical outcomes between ultrasound (US)-guided percutaneous microwave ablation (MWA) and surgical resection (SR) in patients with thoracoabdominal wall implants from hepatocellular carcinom (HCC) and to identify the prognostic factors associated with the two treatment methods. MATERIALS AND METHODS: A total of 47 patients (mean age, 56.7 ± 15.9 years, range, 18-78 years; 34 men and 13 women) with 61 thoracoabdominal wall HCC seeding were included from Apri...
Source: International Journal of Hyperthermia - November 23, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Introduction to thyroid collection issue.
Authors: Mauri G PMID: 29164991 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - November 23, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Factors associated with recurrence of BTN after ablation.
Authors: Wang B, Han ZY, Yu J, Liang P PMID: 29164992 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - November 23, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Head-out immersion in hot water increases serum BDNF in healthy males.
Authors: Kojima D, Nakamura T, Banno M, Umemoto Y, Kinoshita T, Ishida Y, Tajima F Abstract PURPOSE: Brain-derived neurotrophic factor (BDNF) is an important neurotrophin. The present study investigated the effects of head-out water immersion (HOI) on serum BDNF concentrations. METHODS: Eight healthy men performed 20 min head-out water immersion at 42 °C (hot-HOI) and 35 °C (neutral-HOI). These experimental trials were administered in a randomised order separated by at least 7 days. Venous blood samples were withdrawn at rest, immediately after the 20-min HOI, as well as at 1...
Source: International Journal of Hyperthermia - November 22, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Feasibility of on-line temperature-based hyperthermia treatment planning to improve tumour temperatures during locoregional hyperthermia.
CONCLUSION: On-line temperature-based treatment planning is clinically feasible to improve tumour temperatures. A next, worthwhile step is automatic optimisation for a larger number of patients. PMID: 29145750 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - November 19, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The usefulness of mobile insulator sheets for the optimization of deep heating area for regional hyperthermia using a capacitively-coupled heating method: Phantom, simulation and clinical prospective studies.
CONCLUSIONS: Our novel heating method using mobile insulator sheets was thus found to improve the thermal dose parameters. Further investigations are expected. PMID: 29108446 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - November 9, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Cross-sectional area of the murine aorta linearly increases with increasing core body temperature.
Authors: Crouch AC, Manders AB, Cao AA, Scheven UM, Greve JM Abstract PURPOSE: The cardiovascular (CV) system plays a vital role in thermoregulation. To date, the response of core vasculature to increasing core temperature has not been adequately studied in vivo. Our objective was to non-invasively quantify the arterial response in murine models due to increases in body temperature, with a focus on core vessels of the torso and investigate whether responses were dependent on sex or age. METHODS: Male and female, adult and aged mice were anaesthetised and underwent magnetic resonance imaging (MRI). Data were acq...
Source: International Journal of Hyperthermia - November 8, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Perivascular extension of Microwave ablation zone - demonstrated using an ex-vivo porcine perfusion liver model.
Authors: Singh S, Siriwardana PN, Johnston EW, Watkins J, Bandula S, Illing R, Davidson BR Abstract Microwave ablation (MWA) has been proposed to suffer less from the heat sink effect compared to radiofrequency ablation but has been reported to cause extension of the ablation zone along intrahepatic vessels in clinical practice. To study this effect in detail, eight fresh porcine livers were perfused in an ex-vivo organ perfusion system. Livers were perfused with oxygenated, O-positive human blood at 37°C. Perfusion was discontinued immediately before ablation in the non-perfused group (n = 4) whi...
Source: International Journal of Hyperthermia - November 5, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Thermal ablation of hepatocellular carcinoma in patients with abnormal coagulation function.
Authors: Huang Q, Xu E, Tan L, Zeng Q, Zheng R, Li K Abstract OBJECTIVE: To evaluate the safety of thermal ablation for hepatocellular carcinoma (HCC) in patients with abnormal coagulation function. METHODS: Fifty-seven HCC tumours in 50 patients were treated with thermal ablation. All patients had a meted platelet count 
Source: International Journal of Hyperthermia - November 1, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The efficacy and safety of microwave ablation in patients with retroperitoneal metastases.
CONCLUSION: MWA for the treatment of retroperitoneal metastases was effective and the complications were common. PMID: 29082799 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - November 1, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The pre-operative neutrophil-lymphocyte ratio predicts overall and disease-free survival following cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with pseudomxyoma peritonei of appendiceal origin.
CONCLUSION: The pre-operative NLR is cost effective and has equivalent prognostic value to pre-operative tumour markers for patients with PMP treated with CRS and HIPEC. The NLR is a reliable tool that may have a role in predicting outcomes following CRS and HIPEC for patients with PMP of appendiceal origin. PMID: 29063804 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 26, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Target visualisation and microwave hyperthermia monitoring using nanoparticle-enhanced transmission ultrasound (NETUS).
Authors: Perlman O, Weitz IS, Azhari H Abstract PURPOSE: The aim of this study was to examine the feasibility of using nanoparticle-enhanced transmission ultrasound (NETUS) as an image-based monitoring modality for microwave hyperthermia treatment. METHODS: A dedicated transmission ultrasound imaging system was used to obtain acoustic projections and ultrasound computed tomography images. Initially, speed-of-sound based images were used to non-invasively monitor temperature changes in in vitro and ex vivo specimens, induced by a microwave needle-type applicator. Next, the hyperthermia acceleration ability of tw...
Source: International Journal of Hyperthermia - October 26, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Commentary on the clinical and preclinical dosage limits of interstitially administered magnetic fluids for therapeutic hyperthermia based on current practice and efficacy models.
Authors: Southern P, Pankhurst QA Abstract We offer a critique of what constitutes a suitable dosage limit, in both clinical and preclinical studies, for interstitially administered magnetic nanoparticles in order to enable therapeutic hyperthermia under the action of an externally applied alternating magnetic field. We approach this first from the perspective of the currently approved clinical dosages of magnetic nanoparticles in the fields of MRI contrast enhancement, sentinel node detection, iron replacement therapy and magnetic thermoablation. We compare this to a simple analytical model of the achievable hyper...
Source: International Journal of Hyperthermia - October 20, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasonography-guided percutaneous microwave ablation for large hepatic cavernous hemangiomas.
Authors: Liu F, Yu X, Liang P, Cheng Z, Han Z, Yu J Abstract PURPOSE: To evaluate the efficacy and safety of ultrasound-guided percutaneous microwave ablation (MWA) for large hepatic cavernous hemangiomas (HCHs) with ablation of the feeding artery and aspiration of blood from hemangioma simultaneously. MATERIALS AND METHODS: From January 2011 to December 2016, 40 patients (29 females, 11male; average age 43.25±7.65 years) with 42 giant hepatic hemangiomas (mean diameter7.02±1.55cm, range4.1-10.8 cm) were treated with image-guided percutaneous MWA with ablation of the feeding artery and aspi...
Source: International Journal of Hyperthermia - October 16, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The effects of head-cooling on brain function during passive hyperthermia: an fMRI study.
CONCLUSIONS: Head-cooling could substantially reduce the negative effect of hyperthermia on human brain activity as well as thermal sensation. PMID: 29025324 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 16, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Versatility of Targeted Antibiotic-loaded Gold Nanoconstructs for the Treatment of Biofilm-associated Bacterial Infections.
CONCLUSION: These results confirm the therapeutic versatility of our approach. However, to the extent that its synergistic efficacy is dependent on the ability to achieve both a lethal photothermal effect and the thermally-controlled release of a sufficient amount of antibiotic, they also demonstrate the importance of carefully designing appropriate antibody and antibiotic combinations to achieve the desired therapeutic synergy. PMID: 29025325 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 16, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Application of microwave ablation in the emergent control of intraoperative life threatening tumor hemorrhage during hepatic surgeries.
CONCLUSIONS: MWA may be a feasible, effective and simple strategy for the emergent control of intraoperative hepatic tumor bleeding. To the best of our knowledge, this study represents the first reported cases of this novel application of MWA. PMID: 28982246 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 7, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Combined Radiofrequency Ablation and Ethanol Injection Versus Repeat Hepatectomy for Elderly Patients with Recurrent Hepatocellular Carcinoma after Initial Hepatic Surgery.
Authors: Chen S, Peng Z, Xiao H, Lin M, Chen Z, Jiang C, Hu W, Xie X, Liu L, Peng B, Kuang M Abstract PURPOSE: To retrospectively compare the efficacy and safety of combined radiofrequency ablation and percutaneous ethanol injection (RFA-PEI) with repeat hepatectomy for elderly patients with initial recurrent hepatocellular carcinoma (HCC) after hepatic surgery. METHODS: From January 2009 to June 2015, 105 elderly patients (≥ 70 years) who underwent RFA-PEI (n = 57) or repeated hepatectomy (n = 48) for recurrent HCC ≤ 5.0 cm were included in the study. The overall surviv...
Source: International Journal of Hyperthermia - October 6, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The Oncologic Results of Cryoablation in Prostate Cancer Patients with Bone Metastases.
Authors: Si T, Guo Z, Yang X, Zhang W, Xing W Abstract OBJECTIVE: To explore the role of whole gland cryoablation plus ADT in prostate cancer (PCa) with bone metastases compared with ADT treatment alone in metastatic PCa. METHODS: A total of 30 patients with biopsy proven PCa with bone metastases underwent cryoablation and ADT treatment. The control group consisted of 30 men who were initially treated with ADT only and who were followed until progression, development of castration resistant PCa or death. Patients were pair-matched for age, PSA level, clinical stage, preoperative biopsy Gleason score, and bone m...
Source: International Journal of Hyperthermia - October 6, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A Review of Immune Therapy in Cancer and a Question: Can Thermal Therapy Increase Tumor Response?
Authors: Bull JMC Abstract Immune therapy is a successful cancer treatment coming into its own. This is because checkpoint molecules, adoptive specific lymphocyte transfer, and CAR-T therapy are able to induce more responses and more durable responses in an increasing number of malignancies compared to chemotherapy. In addition, immune therapies are able to treat bulky disease, whereas standard cytotoxic therapies cannot treat large tumor burdens. Checkpoint inhibitor monoclonal antibodies are becoming widely used in the clinic; and although more complex, adoptive lymphocyte transfer and CAR-T therapies show promis...
Source: International Journal of Hyperthermia - October 6, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Activation of hypoxia-inducible factor-1 in rat brain after perinatal anoxia: role of body temperature.
Authors: Kletkiewicz H, Hyjek M, Jaworski K, Nowakowska A, Rogalska J Abstract Transcriptional hypoxia-inducible factor-1α (HIF-1α) plays the fundamental role in adaptive processes in response to hypoxia. Specific HIF-1α target genes are involved in glycolysis, erythropoiesis and angiogenesis to promote survival. In our previous study we have demonstrated that naturally low body temperature of newborn rats protects them against damage due to perinatal hypoxia. Therefore, our experiments aimed at checking the effects of body temperature during simulated perinatal anoxia on subsequent changes of exp...
Source: International Journal of Hyperthermia - October 6, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Exploring the trend in referrals for consideration of CRS and HIPEC to understand the attitudes of clinicians in the development of a national cancer centre program in peritoneal disease.
CONCLUSIONS: There is growing acceptance of CRS and HIPEC in patients and oncologic-related departments. However, consideration of this procedure as a treatment option remains low in non-oncologic departments. Dissemination of information and well-defined clinical recommendations may help physicians identify and select potentially eligible patients for consideration of CRS and HIPEC. PMID: 28978237 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 6, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Correction to: Tan et al., Diagnostic and therapeutic laparoscopy in assessment and management of patients with appendiceal neoplasms.
Authors: PMID: 28967270 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 3, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Heat stress induced, ligand-independent MET and EGFR signaling in hepatocellular carcinoma.
CONCLUSIONS: Heat stress induced MET and EGFR signaling is distinct from growth factor mediated signaling in HCC cells and MET inhibition enhances heat stress induced HCC cell killing via a PI3K/AKT/mTOR-independent mechanism. PMID: 28954551 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 30, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Two Questions about the Analysis and Interpretation of Randomized Trials.
Authors: Samsa G, Neely M Abstract This non-technical tutorial focus on two questions about the analysis of data from randomized trials. Which is the more appropriate analysis of data from a randomized trial - an unadjusted analysis or an adjusted one? When a result is not statistically significant is it nevertheless appropriate to comment on its direction? PMID: 28954558 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 30, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Hyperthermia treatment planning guided applicator selection for sub-superficial head and neck tumors heating.
CONCLUSION: Simulations predict that the HYPERcollar (hence also its successor the HYPERcollar3D) is to be preferred over planar applicators such as LCA and current sheet applicator in sub-superficial tumors in the H&N region when used within specifications. PMID: 28931333 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 23, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Erratum.
Authors: PMID: 28925283 [PubMed] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 22, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Thalamocortical neural responses during hyperthermia: A resting-state functional MRI study.
In this study, we performed exploratory analyses comparing thalamocortical functional connectivity during whole body hyperthermic condition for an hour at 50°C and normothermic condition at 25°C. We found weakened functional connectivity of cortical fronto-polar/anterior cingulate cortex and prefrontal areas with the corresponding thalamic nuclei during hyperthermic versus normothermic comparisons. On the contrary, the motor/premotor, somatosensory and temporal cortical subdivisions showed increased connectivity with thalamic nuclei during hyperthermia. Thalamocortical connectivity changes in the prefrontal were id...
Source: International Journal of Hyperthermia - September 22, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

BRCA2 protects mammalian cells from heat shock.
CONCLUSION: BRCA2 has a protecting role against heat-induced cell death. BRCA2 might be a potential molecular target for hyperthermic cancer therapy. PMID: 28891354 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 13, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparative efficacy evaluation of catheter intraperitoneal chemotherapy, normothermic and hyperthermic chemoperfusion in a rat model of ascitic ovarian cancer.
CONCLUSIONS: Dioxadet and cisplatin show similar efficacy in the CIPC route. Compared with CIPC IP chemotherapy by chemoperfusions is more effective for both of the drugs. Dioxadet in HIPEC showed highest survival benefit whereas largest effect during NIPEC is achieved with cisplatin. PMID: 28893108 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 13, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for the treatment of advanced epithelial and recurrent ovarian carcinoma: a single center experience.
CONCLUSIONS: In advanced or recurrent EOC, a curative therapeutic approach was pursued that combined optimal cytoreductive surgery and intraperitoneal chemotherapy. PCI and timing of the intervention (primary or recurrent) were the strongest independent prognostic factors. PMID: 28877609 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 9, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The role of MRI in the early evaluation of lung microwave ablation.
CONCLUSION: A ceMRI performed 24h after MWA of lung tumors has a similar ability to predict LTP and detect important complications as a CT has. PMID: 28877612 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 9, 2017 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research