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Analysis of Clinical Data to Determine the Minimum Number of Sensors Required for Adequate Skin Temperature Monitoring of Superficial Hyperthermia Treatments.
CONCLUSIONS: Adequate coverage of the skin temperature distribution during superficial hyperthermia treatment requires the use of>50 stationary sensors per 400 cm2 applicator. Thermal mapping is a valid alternative. PMID: 29658357 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 18, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Radiofrequency ablation (RFA) induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins.
Authors: Ahmed M, Kumar G, Gourevitch S, Levchenko T, Galun E, Torchilin V, Goldberg SN Abstract PURPOSE: To determine the role of hepatic RFA heating parameters and their activation of heat shock proteins (HSPs) in modulating distant tumor growth. METHODS: First, to study effects of RFA dose on distant tumor growth, rats with subcutaneous R3230 adenocarcinoma (10 ± 1 mm) were assigned to 3 different hepatic RF doses (60°C × 10 min, 70°C × 5 min, or 90°C × 2 min) that induced identical sized ablation or sham (n = 6/arm). Post-RFA tum...
Source: International Journal of Hyperthermia - April 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided percutaneous microwave ablation versus surgery for papillary thyroid microcarcinoma.
Authors: Li J, Liu Y, Liu J, Qian L Abstract BACKGROUND: Papillary thyroid microcarcinoma (PTMC) has high incidence and low disease-specific mortality. However, active surveillance is not accepted by most patients owing to high physical or psychological pressures. The emergence of ablation technologies is supplanting traditional surgery. Our goal was to compare the clinical outcomes of microwave ablation (MWA) and surgery for T1aN0M0 PTMC. METHODS: A total of 92 consecutive patients with T1aN0M0 PTMC were studied retrospectively. Forty-six patients had been treated with MWA, and the other 46 had undergone surge...
Source: International Journal of Hyperthermia - April 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Feasibility of bipolar radiofrequency ablation in patients with parathyroid adenoma: A first evaluation.
CONCLUSION: For the first time, it was possible to depict the successful therapy of parathyroid adenoma by means of bRFA. This work thus proves bRFA to be an effective, safe, applicable and, concerning sensation of pain, very well tolerable thermoablative technique in the treatment of parathyroid adenoma. PMID: 29607692 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 4, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave Ablation Compared to Thyroidectomy to Treat Benign Thyroid Nodules.
CONCLUSIONS: MWA can significantly reduce nodule volume and nodule-related symptoms with more rapid recovery, more pleasing esthetic outcomes, less physiologic disruption and less expense compared to the surgery. PMID: 29577796 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 28, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A Multimodality Imaging-compatible Insertion Robot with A Respiratory Motion Calibration Module Designed for Ablation of Liver Tumors: A Preclinical Study.
CONCLUSION: The multimodality imaging-compatible insertion robot with a respiratory motion calibration module designed for ablation of liver tumors could increase the insertion accuracy and ablation efficacy, and minimize the influence of the physicians' experience. The ablation procedure could be more comfortable with less stress with the application of the robot. PMID: 29566561 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 25, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Transurethral High Intensity Ultrasound for Treatment of Stress Urinary Incontinence (SUI): Simulation Studies with Patient Specific Models.
The objective of this in silico study is to explore transurethral high intensity ultrasound for delivery of precise thermal therapy to the endopelvic tissues adjacent to the mid-urethra, to induce thermal remodelling as a potential minimally invasive treatment alternative. METHODS: 3D acoustic (Rayleigh-Sommerfeld) and biothermal (Pennes Bioheat) models of the ultrasound applicator and surrounding tissues were devised. Parametric studies over transducer configuration (frequency, radius-of-curvature (ROC)) and treatment settings (power, duration) were performed, and select cases on patient specific models were used for ...
Source: International Journal of Hyperthermia - March 25, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Factors influencing thermal injury to skin and abdominal wall structures in HIFU ablation of uterine fibroids.
Authors: Yin N, Hu L, Xiao ZB, Liu C, Chen WZ, Roberts N, Chen JY, Wang ZB Abstract OBJECTIVE: To investigate the factors which may cause thermal injury of abdominal wall structures in ultrasound-guided high-intensity focussed ultrasound (USgHIFU) ablation of uterine fibroids. METHOD: A total of 892 patients with uterine fibroids diagnosed on contrast-enhanced magnetic resonance imaging (MRI) scans received HIFU ablation and follow-up MRI scanning. After therapy, thermal injury to the skin was assessed via measurement of skin redness, blisters, subcutaneous nodules and to the abdominal wall structures via measu...
Source: International Journal of Hyperthermia - March 8, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Local recurrence rate in patients with colorectal cancer liver metastasis after wedge resection or percutaneous radiofrequency ablation.
Authors: Vietti Violi N, Duran R, Demartines N, Sempoux C, Guiu B, Bize PE, Sala N, Halkic N, Knebel JF, Denys A Abstract PURPOSE: To compare local recurrence (LR) rate in patients with colorectal cancer liver metastasis (CRCLM) after surgical wedge resection (WR) or radiofrequency ablation (RFA) and to investigate predictive factors of LR. MATERIALS AND METHODS: This single-centre, retrospective, institutional review board-approved study including 43 consecutive patients with 121 metastases treated by WR and 60 patients with 110 metastases treated by RFA between 2007 and 2014 with 23 and 18.5 months of ...
Source: International Journal of Hyperthermia - March 8, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Locoregional hyperthermia of deep-seated tumors applied with capacitive and radiative systems: a simulation study.
CONCLUSION: Generally, radiative locoregional heating yields more favorable simulated temperature distributions for deep-seated pelvic tumors, compared with capacitive heating. Therapeutic temperatures are predicted for capacitive heating in patients with (almost) no fat. PMID: 29509043 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 8, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Inactivation kinetics of food-borne pathogens subjected to thermal treatments: a review.
This study presents a comprehensive review of recent progresses in inactivation kinetics of food-borne pathogens. It covers theoretical bases and experimental methods for developing thermal inactivation kinetics of food-borne pathogens and making comparisons and applications of the common thermal death kinetic models. Finally, it proposes possible recommendations on the future research directions of establishing inactivation kinetic models for food-borne pathogens in thermal processing. PMID: 29498308 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Temperature-sensitive liposomal ciprofloxacin for the treatment of biofilm on infected metal implants using alternating magnetic fields.
In this study, we treated a metal prosthesis infection model using a combination of ciprofloxacin-loaded temperature-sensitive liposomes (TSL) and alternating magnetic fields (AMF). AMF heating is used to disrupt the biofilm and release the ciprofloxacin-loaded TSL. The three main objectives of this study were to (1) investigate low- and high-temperature-sensitive liposomes (LTSLs and HTSLs) containing the antimicrobial agent ciprofloxacin for temperature-mediated antibiotic release, (2) characterise in vitro ciprofloxacin release and stability and (3) study the efficacy of combining liposomal ciprofloxacin with AMF agains...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity.
Authors: Bucsek MJ, Giridharan T, MacDonald CR, Hylander BL, Repasky EA Abstract Stress in patients and pre-clinical research animals plays a critical role in disease progression Activation of the sympathetic nervous system (SNS) by stress results in secretion of the catecholamines epinephrine (Epi) and norepinephrine (NE) from the adrenal gland and sympathetic nerve endings. Adrenergic receptors for catecholamines are present on immune cells and their activity is affected by stress and the accompanying changes in levels of these neurotransmitters. In this short review, we discuss how this adrenergic stress impacts...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Heat transfer from nanoparticles for targeted destruction of infectious organisms.
Authors: Cortie MB, Cortie DL, Timchenko V Abstract Whereas the application of optically or magnetically heated nanoparticles to destroy tumours is now well established, the extension of this concept to target pathogens has barely begun. Here we examine the challenge of targeting pathogens by this means and, in particular, explore the issues of power density and heat transfer. Depending on the rate of heating, either hyperthermia or thermoablation may occur. This division of the field is fundamental and implies very different sources of excitation and heat transfer for the two modes, and different strategies for th...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Thermal shock susceptibility and regrowth of Pseudomonas aeruginosa biofilms.
Authors: Ricker EB, Aljaafari HAS, Bader TM, Hundley BS, Nuxoll E Abstract Biofilms on implanted medical devices cause thousands of patients each year to undergo multiple surgeries to remove and replace the implant, driving billions of dollars in increased health care costs due to the lack of viable treatment options for in situ biofilm eradication. Remotely activated localised heating is under investigation to mitigate these biofilms; however, little is known about the temperatures required to kill the biofilms. To better understand the required parameters this study investigated the thermal susceptibility of biof...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Introduction to the special issue on thermal therapy and infectious diseases.
Authors: Chopra R, Levi-Polyachenko N, Smeltzer MS PMID: 29498313 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Progress on utilizing hyperthermia for mitigating bacterial infections.
Authors: Ibelli T, Templeton S, Levi-Polyachenko N Abstract Recovery from systemic or local bacterial infections can be lengthy and costly, with the clinical challenges being further complicated when bacteria acquire resistance to current antibiotics. Hyperthermia offers new mechanisms for removing bacteria via ablation, or sensitising them to chemical agents. The first part of this review provides a background on the bacterial biofilms, their response to hyperthermia, and acquired resistance to antibiotics, followed by the clinical challenges they present in managing infections associated with soft tissues and bio...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison between single- and dual-porosity models for fluid transport in predicting lesion volume following saline-infused radiofrequency ablation.
Authors: Ooi EH, J Y Chia N, Ooi ET, Foo JJ, Liao IY, R Nair S, Mohd Ali AF Abstract A recent study by Ooi and Ooi (EH Ooi, ET Ooi, Mass transport in biological tissues: Comparisons between single- and dual-porosity models in the context of saline-infused radiofrequency ablation, Applied Mathematical Modelling, 2017, 41, 271-284) has shown that single-porosity (SP) models for describing fluid transport in biological tissues significantly underestimate the fluid penetration depth when compared to dual-porosity (DP) models. This has raised some concerns on whether the SP model, when coupled with models of radiofreque...
Source: International Journal of Hyperthermia - March 2, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects.
Authors: Kodama H, Ueshima E, Gao S, Monette S, Paluch LR, Howk K, Erinjeri JP, Solomon SB, Srimathveeravalli G Abstract PURPOSE: To assess the impact of duration of energy delivery on adverse events (AEs) and heat sink effects during high power microwave ablation (MWA) of normal swine lung. MATERIALS AND METHODS: High power (100 Watts) MWA was performed with short (2 minutes, 18 ablations) or long (10 minutes, 9 ablations) duration of energy delivery in unilateral lung of swine (n = 10). CT imaging was done prior to sacrifice at 2 or 28 days post-treatment, with additional imaging a...
Source: International Journal of Hyperthermia - March 2, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Laser immunotherapy for cutaneous squamous cell carcinoma with optimal thermal effects to enhance tumor immunogenicity.
Authors: Luo M, Shi L, Zhang F, Zhou F, Zhang L, Wang B, Wang P, Zhang Y, Zhang H, Yang D, Zhang G, Chen WR, Wang X Abstract BACKGROUND: Laser immunotherapy is a new anti-cancer therapy combining photothermal therapy and immunostimulation. It can eliminate the tumors by damaging tumor cells directly and promoting the release of damage-associated molecular patterns (DAMPs) to enhance tumor immunogenicity. The aim of this study was to investigate the thermal effects of laser immunotherapy and to evaluate the effectiveness and safety of laser immunotherapy for cutaneous squamous cell carcinoma (cSCC). METHODS: The...
Source: International Journal of Hyperthermia - March 1, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Technical analysis of US imaging for precise microwave ablation for benign breast tumours.
Authors: Li C, Li C, Ge H, Liang M, Ma G, Ling L, Pan H, Gong H, Xie H, Ding Q, Zhou W, Wang S Abstract PURPOSE: To determine thecharacteristicsof ultrasound (US) imaging of completelyablated cases and theeffects of duration and clinical experience on accurate microwave ablation (MWA) for the treatment of benign breast tumours. METHODS: With written informed consent and approval of the institutional ethics committee, patients with symptomatic or palpable benign breast tumours (longest diameter, 7-32mm), to whom MWA (2450MHz) was performed, were enrolled in this prospective nonrandomized study.US and contrast-en...
Source: International Journal of Hyperthermia - February 21, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Proceedings of the First Italian Conference on Thyroid Minimally Invasive Treatments and foundation of the Italian Research Group for Thyroid Minimally Invasive Procedures.
Authors: Mauri G, Pacella CM, Papini E, Sconfienza LM, Solbiati L PMID: 29455559 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 20, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Hepatocellular carcinoma abutting large vessels: Comparison of four percutaneous ablation systems.
CONCLUSION: Multi-applicator RFA provides better local tumor control in HCC abutting large vessels than single-applicator techniques (monopolar RFA or MWA). PMID: 29457510 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 20, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Safety and effect on ablation size of Hydrochloric Acid-perfused Radiofrequency Ablation in animal livers.
Authors: Zhang TQ, Huang SM, Gu YK, Gao F, Huang ZM, Jiang XY, Liu DX, Huang JH Abstract PURPOSE: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissue, prospectively using in vivo rabbit and ex vivo porcine liver models. MATERIALS AND METHODS: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103°C and 30 W for 3 minutes. For each experimental setting, 6 ablations were created. Safety was assessed by comparing bas...
Source: International Journal of Hyperthermia - February 20, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Summary of numerical analyses for therapeutic uses of laser-activated gold nanoparticles.
Authors: Mesicek J, Kuca K Abstract The optimal light dose, heat generation, consequent heat spread, and an accurate thermal damage model, are key components of effective laser therapies. Recent advances in nanotechnology offer numerous possibilities on how to increase the efficacy of hyperthermia for tumour treatments. Gold nanoparticles are a promising candidate towards the achievement of this goal owing to their properties for efficiently converting light to heat. In this review, we summarise the numerical tools that are available for theoretical studies of gold-nanoparticle-mediated photo-thermal therapy. The p...
Source: International Journal of Hyperthermia - February 17, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Effect of pretreatment with gonadotropin-releasing hormone analog GnRH- α on high-intensity focused ultrasound ablation for diffuse adenomyosis: a preliminary study.
Effect of pretreatment with gonadotropin-releasing hormone analog GnRH-α on high-intensity focused ultrasound ablation for diffuse adenomyosis: a preliminary study. Int J Hyperthermia. 2018 Feb 15;:1-19 Authors: Zhang XY, Guo YS, Chen JM, Wang JJ, Ye H, Zang CY, Duan H Abstract OBJECTIVES: To evaluate the efficacy and safety of GnRH-α pretreatment with HIFU ablation for diffuse adenomyosis. METHODS: From January 2014 to December 2016, 61 patients were divided into two groups. Twenty-three patients with larger uteri received pretreatment with GnRH-αand were then subjected to HIFU, ...
Source: International Journal of Hyperthermia - February 17, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Are infectious diseases and microbiology new fields for thermal therapy research?
Authors: Gazel D, Yılmaz M Abstract Antimicrobial chemotherapy and surgery are classical methods for treating infectious diseases. However, there is a need for alternative methods to cure infections caused by antibiotic-resistant pathogens, recurrent or chronic infections, and unreachable local infections in which the use of drugs or surgery is anatomically and physically restricted. Several microorganisms are known to be sensitive to mild hyperthermia, and this sensitivity is one of the potential benefits proposed for the host during an episode of fever. Additionally, some immunological or biophysical changes occ...
Source: International Journal of Hyperthermia - February 17, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Mechanical Fractionation of Tissues using Microsecond-Long HIFU Pulses on a Clinical MR-HIFU System.
CONCLUSION: Clinical MR-HIFU system was utilized to generate distinct types of lesions and to produce targeted thermomechanical bioeffects in ex vivo tissues. The results guide HIFU research on thermomechanical tissue bioeffects, inform future studies, and advice sonication parameter selection for direct tumor ablation or immunomodulation using a clinical MR-HIFU system. PMID: 29429375 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 14, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma and predictors of survival.
CONCLUSION: With adequate patient selection (guided by histological classification and Ki-67 proliferation index) and complete cytoreduction with HIPEC, satisfactory outcomes can be achieved in selected patients with peritoneal mesothelioma. PMID: 29431036 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 14, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Intra-articular application of pulsed radiofrequency combined with viscosupplementation for improvement of knee osteoarthritis symptoms: a single centre prospective study.
Authors: Filippiadis D, Velonakis G, Mazioti A, Konstantos C, Brountzos E, Kelekis N, Kelekis A Abstract OBJECTIVES: To prospectively evaluate the effectiveness of intra-articular application of pulsed radiofrequency (PRF) combined with viscosupplementation in patients with knee osteoarthritis suffering from chronic pain refractory to conservative therapies. METHODS: During a 30-month period, PRF combined with viscosupplementation was performed on 53 cases of knee osteoarthritis (45 patients, 8/45 with bilateral knee osteoarthritis). Pre-operational imaging included standard knee X-rays on anterior-posterior an...
Source: International Journal of Hyperthermia - February 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Radiofrequency ablation for the treatment of knee osteoarthritis: present status and future perspectives.
Authors: Cazzato RL, Garnon J, Caudrelier J, Rao PP, Koch G, Gangi A PMID: 29417857 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A Single Session of Laser Ablation for Toxic Thyroid Nodules: Three-year Follow up Results.
Authors: Gambelunghe G, Stefanetti E, Colella R, Monacelli M, Avenia N, De Feo P Abstract PURPOSE: To confirm the effectiveness of laser ablation on toxic nodules in a large population with three years of follow-up. MATERIAL AND METHODS: Between 2009 and 2014, we treated 82 patients with hyperthyroidism related to the presence of a toxic nodular goiter. Patients were pre-treated pharmacologically with methimazole prior to single session of laser ablation (LA) and then followed up every 3 months with FT4 and TSH blood tests as well as ultrasound examination of the nodules treated. RESULTS: All patients respo...
Source: International Journal of Hyperthermia - February 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ex vivo comparison between thyroid-dedicated bipolar and monopolar radiofrequency electrodes.
This study evaluated the characteristics of a thyroid-dedicated bipolar RF electrode (BRFE) and compared its ablation performance with that of monopolar RF electrodes (MRFEs) in normal bovine liver blocks Methods: BRFE was tested on 60 bovine liver blocks with six different time-power combinations, applying 20, 30, and 40 watts (W) for 60 and 120 seconds (sec). Subsequently, BRFE and MRFEs with 0.5-, 0.7- and 1-cm active tips were applied on 160 bovine liver blocks, creating 16 time-electrode combinations (10, 30, 60, 120 sec). The ablation characteristics, RF efficacy and true RF efficacy of each electrode g...
Source: International Journal of Hyperthermia - February 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

In vivo monitoring of microwave ablation in a porcine model using ultrasonic differential attenuation coefficient intercept imaging.
In this study, the feasibility of using ultrasonic differential attenuation coefficient intercept (Δα0) imaging to evaluate thermal lesions induced by microwave ablation (MWA) was explored using an in vivo porcine model. The attenuation coefficient intercept (α0) is defined as the attenuation coefficient at the center frequency of the ultrasound transmitted pulse. Δα0 is estimated by subtracting an initial value of α0 from the value calculated during MWA. Thermal lesions were induced in the livers (N = 9) and kidneys (N = 7) of five domestic pigs using a clini...
Source: International Journal of Hyperthermia - February 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

RF-Energized Intracoronary Guidewire to Enhance Bipolar Ablation of the Interventricular Septum: In-silico Feasibility Study.
CONCLUSIONS: An RF-energized guidewire could enhance bipolar RFA by allowing transmural lesions to be made through thick ventricular walls. However, the safety of this new approach must be assessed in future pre-clinical studies, especially in terms of the risk of stenosis and its clinical impact. PMID: 29392974 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 4, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Safety margin after radiofrequency ablation of hepatocellular carcinoma: precise assessment with a three-dimensional reconstruction technique using CT imaging.
Authors: Jiang C, Liu B, Chen S, Peng Z, Xie X, Kuang M Abstract PURPOSE: To analyse the precise ablative margin (AM) after radiofrequency ablation (RFA) for hepatocellular carcinoma (HCC) and the correlation between AM and local tumour progression (LTP) with a three-dimension (3D) reconstruction technique. METHODS: From March 2011 to May 2013, 134 patients who underwent RFA for 159 primary or recurrent HCCs within Milan criteria were enrolled. Contrast-enhanced computed tomography (CECT) scans were performed 1 week before and 1 month after treatment. The AM was measured in various directions usin...
Source: International Journal of Hyperthermia - February 4, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Real-time 3D ultrasound based motion tracking for the treatment of mobile organs with MR-guided High Intensity Focused Ultrasound.
CONCLUSION: This standalone 3D ultrasound-based motion correction technique is robust and allows maintaining the HIFU focal spot in the presence of motion without adding any burden or complexity to MR thermal imaging. In vitro and in vivo results showed about 35% improvement in heating efficiency when focus position was locked on the target using the proposed technique. PMID: 29378441 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 31, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison between Microwave Ablation and Lobectomy for Stage I Non-small Cell Lung Cancer: A Propensity Score Analysis.
CONCLUSION: Microwave ablation has similar therapeutic effect compared with lobectomy for stage I non-small cell lung cancer, but with fewer complication and less pain. PMID: 29378462 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 31, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave ablation induces a lower systemic stress response in patients than open surgery for treatment of benign thyroid nodules.
CONCLUSION: Microwave ablation induces a lower systemic stress response than open surgery for treatment of benign thyroid nodules. PMID: 29366346 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 27, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Nodule Size as Predictive Factor of Efficacy of Radiofrequency Ablation in Treating Autonomously Functioning Thyroid Nodules.
Authors: Cesareo R, Naciu AM, Iozzino M, Pasqualini V, Simeoni C, Casini A, Campagna G, Manfrini S, Tabacco G, Palermo A Abstract CONTEXT: No defined pretreatment factors are able to predict the response to radiofrequency ablation(RFA) of an autonomously functioning thyroid nodule(AFTN). OBJECTIVE: primary endpoint was to evaluate the success rate of RFA to restore euthyroidism in a cohort of adult patients with small solitary AFTN compared with medium-sized nodules. Secondary endpoints included nodule volume reduction and rate of conversion from hot nodules to cold using scintiscan. METHODS: This was a 24-...
Source: International Journal of Hyperthermia - January 25, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave-assisted liver resection versus clamp crushing liver resection in cirrhosis patients with hepatocellular carcinoma.
This study aimed to evaluate the safety and effectiveness of microwave-ablation-assisted liver resection (MW-LR) and clamp crushing liver resection (CC-LR) in cirrhotic patients with hepatocellular carcinoma (HCC). MATERIALS AND METHODS: From July 2005 to January 2015, cirrhotic HCC patients who underwent CC-LR (n = 191) or MW-LR (n = 112) were retrospectively analyzed. We compared morbidity, mortality, disease-free survival time, and overall survival time between the CC-LR and MW-LR groups. RESULTS: The blood loss volume was significantly higher in the CC-LR group (mean of 752 ml...
Source: International Journal of Hyperthermia - January 24, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Magnetic hyperthermia therapy for the treatment of glioblastoma: a review of the therapy's history, efficacy, and application in humans.
Authors: Mahmoudi K, Bouras A, Bozec D, Ivkov R, Hadjipanayis C Abstract Hyperthermia therapy (HT) is the exposure of a region of the body to elevated temperatures to achieve a therapeutic effect. HT anticancer properties and its potential as a cancer treatment have been studied for decades. Techniques used to achieve a localized hyperthermic effect include radiofrequency, ultrasound, microwave, laser, and magnetic nanoparticles (MNPs). The use of MNPs for therapeutic hyperthermia generation is known as magnetic hyperthermia therapy (MHT) and was first attempted as a cancer therapy in 1957. However, despite more re...
Source: International Journal of Hyperthermia - January 24, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

SAR thresholds for electromagnetic exposure using functional thermal dose limits.
CONCLUSIONS: Our analysis provides clear instructions for calculation of SARTDFL and consequently quantification of the incorporated safety factor in the current basic restrictions. This research can form the basis for further discussion on establishing the guidelines dedicated to a specific exposure scenario, i.e. exposure-specific SAR limits, rather than the current generic guidelines. PMID: 29347853 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 21, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Low-power bipolar radiofrequency ablation and vertebral augmentation for the palliative treatment of spinal malignancies.
Authors: Cazzato RL, Garnon J, Caudrelier J, Rao PP, Koch G, Gangi A Abstract AIM: To investigate the analgesic properties and the safety of low power bipolar radiofrequency ablation (RFA) performed with internally cooled electrodes and vertebral augmentation for the treatment of painful spinal malignancies. MATERIALS AND METHODS: Consent was waived for retrospective study participation. Review of electronic records identified 11 consecutive patients (6 females; 5 males; mean age 61.3 ± 11.6 years) with one-index painful spinal tumour, who were treated between June 2016 and October 2...
Source: International Journal of Hyperthermia - January 21, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A heterogeneous tissue model for treatment planning for magnetic resonance-guided laser interstitial thermal therapy.
Authors: Mitchell D, Fahrenholtz S, MacLellan C, Bastos D, Rao G, Prabhu S, Weinberg J, Hazle J, Stafford J, Fuentes D Abstract We evaluated a physics-based model for planning for magnetic resonance-guided laser interstitial thermal therapy for focal brain lesions. Linear superposition of analytical point source solutions to the steady-state Pennes bioheat transfer equation simulates laser-induced heating in brain tissue. The line integral of the photon attenuation from the laser source enables computation of the laser interaction with heterogeneous tissue. Magnetic resonance thermometry data sets (n =&thins...
Source: International Journal of Hyperthermia - January 20, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Laser ablation of the biliary tree: in vivo proof of concept as potential treatment of unresectable cholangiocarcinoma.
CONCLUSIONS: The temperature distribution obtained through LA proved to induce a safe and effective intraductal coagulative necrosis of biliary ducts. These results represent the basis for further experiments on tumor-bearing models for the treatment of obstructive cholangiocarcinoma. PMID: 29322853 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 14, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Radiofrequency Ablation of Primary Thyroid Carcinoma: Efficacy According to the Types of Thyroid Carcinoma.
CONCLUSION: In patients with primary thyroid carcinoma, RFA achieved excellent local tumor control for papillary macro- and microcarcinoma; however, its clinical effect on anaplastic carcinoma was questionable. PMID: 29322881 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 14, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Randomized trial of preoperative administration of oral pregabalin for postoperative analgesia in patients scheduled for radiofrequency ablation of focal lesions in the liver.
Authors: Abdelfattah AAM, Rizk F, Hawash N, Hanafy A, El-Kalla F, Abd-Elsalam S Abstract PURPOSE: The aim of this study was to evaluate the effect of preoperative pregabalin on postoperative analgesia in patients undergoing radiofrequency ablation (RFA) of hepatic focal lesions (HFLs). METHODS: This randomized controlled study was carried out on 70 adult patients for whom RFA was indicated to treat hepatocellular carcinoma. They were randomized into two groups: Group I: 35 patients who were given a placebo before the procedure and Group II: 35 patients who were given 150 mg of oral pregabalin one hour be...
Source: International Journal of Hyperthermia - January 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Percutaneous radiofrequency ablation of painful spinal metastasis: a systematic literature assessment of analgesia and safety.
CONCLUSION: RFA, combined with vertebral augmentation in most of the cases, is effective and safe in achieving short to mid-term (from 1 week to 6 months) analgesia in patients affected by painful spinal metastasis. PMID: 29308694 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Real-time estimation of lesion depth and control of radiofrequency ablation within ex vivo animal tissues using a neural network.
CONCLUSIONS: The results show that a NN could make lesion depth estimations in real-time using less in situ devices than current techniques. With the NN-based technique, physicians could deliver quicker and more precise ablation therapy. PMID: 29301446 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - January 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research