Safety and efficacy of thermal ablation (radiofrequency and laser): should we treat all types of thyroid nodules? †.
Conclusions: Transient but potentially serious adverse events were reported in 3% of patients. A significant volumetric reduction was achieved with both techniques, regardless of nodule's characteristics, at 18 months. PMID: 31317800 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 20, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Effects of severe whole-body hyperthermia on ovarian hormone and extracellular Hsp72 responses in young adult women.
Conclusions: In the present study, we show that a severe whole-body hyperthermia (increase in rectal temperature of approximately 2.6 °C and heart rate of approximately 80 bpm from baseline) was sufficient to increase 17β-estradiol, progesterone, and prolactin and catecholamine norepinephrine concentration. Moreover, we show that the concentration of extracellular Hsp72 and catecholamine epinephrine were not affected by severe whole-body hyperthermia in young adult women. From the functional point of view, expression of ovarian hormones induced by passive heat stress may have therapeutic potential for young...
Source: International Journal of Hyperthermia - July 20, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct.
Authors: Ewertowska E, Andaluz A, Moll X, Aguilar A, Garcia F, Fondevila D, Quesada R, Trujillo M, Burdío F, Berjano E Abstract Introduction: Endoluminal sealing of the pancreatic duct by glue or sutures facilitates the management of the pancreatic stump. Our objective was to develop a catheter-based alternative for endoluminal radiofrequency (RF) sealing of the pancreatic duct. Materials and methods: We devised a novel RF ablation technique based on impedance-guided catheter pullback. First, bench tests were performed on ex vivo models to tune up the technique before the in vivo study, after which endolumin...
Source: International Journal of Hyperthermia - July 20, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Intersegmental differences in facial warmth sensitivity during rest, passive heat and exercise.
Conclusion: There were regional differences in facial warmth sensitivity together with different facial temperatures moving toward equilibration when the body is subjected to heat-producing activities. Perceptions of TC were more strongly related to Tface than to Tco or overall body TS. PMID: 31311353 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 18, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Efficacy and safety of microwave ablation for ectopic secondary hyperparathyroidism: a feasibility study.
Authors: Li X, Wei Y, Shao H, Peng L, An C, Yu MA Abstract Objective: To assess the feasibility of microwave ablation (MWA) in treating ectopic secondary hyperparathyroidism (SHPT) in patients with chronic renal failure. Methods: In this retrospective study, MWA was used to manage 22 SHPT nodules in 20 patients. The laboratory test results, including intact parathyroid hormone (iPTH), serum calcium, phosphorus and alkaline phosphatase (ALP) levels; clinical symptoms; complications before, at one day after MWA, and at the end of follow-up were recorded and compared. Both echogenicity and size of SHPT nodules ...
Source: International Journal of Hyperthermia - July 17, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Outcomes of ultrasound-guided percutaneous microwave ablation versus surgical resection for symptomatic large hepatic hemangiomas.
This study aimed to evaluate the safety and effectiveness of MWA compared to SR for large (5-10 cm) hepatic hemangiomas. Methods and materials: This retrospective comparative study included 112 patients with large, symptomatic hepatic hemangiomas who had been treated with MWA (n = 44) or SR (n = 68) and followed up for a median of 44 months using enhanced computed tomography (CT) or magnetic resonance imaging (MRI). Intraoperative information, postoperative recovery time, postoperative discomfort and complications and treatment effectiveness between groups were compared using a chi...
Source: International Journal of Hyperthermia - June 28, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A comparative study of short-term efficacy and safety for thyroid micropapillary carcinoma patients after microwave ablation or surgery.
We examined clinical outcomes during mean follow-up periods of 824 ± 452 days for the TL group and 753 ± 520 days for the MWA group. Results: Postprocedural follow-up revealed that, in the MWA group, the tumors had completely disappeared in 34 patients, and the remainder were reduced to necrotic or carbonized tissue. The incidence of transient hypoparathyroidism was significantly lower in the MWA group than in the TL group (p 
Source: International Journal of Hyperthermia - June 28, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Metabolic response to oral glucose tolerance test performed in neutral and warm environmental temperature.
Conclusion: We conclude that the effects of environmental temperature on the glucoregulatory hormones and biomarkers reported in this study do not explain the exaggerated increase in blood glucose after a glucose load taken in a warm environmental temperature. Precis statement: This work demonstrates in healthy men and women that the ingestion of glucose elicits an exaggerated increase in blood glucose when the environmental temperature is warm. PMID: 31223048 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 22, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Investigation of laser pulsing parameters' importance in Er:YAG laser skin ablation: a theoretical study conducted via newly developed thermo-mechanical ablation model.
Conclusions: Proper tuning of Er:YAG laser pulsing parameters can substantially improve its therapeutic outcomes. The effect of these parameters varies and depends on whether the laser-tissue conditions are ablative or sub-ablative. PMID: 31195904 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 15, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided percutaneous microwave ablation of central intraductal papilloma: a prospective pilot study.
Authors: Yu J, Wu H, Meng XW, Mu MJ, Dou JP, Ahmed M, Liang P Abstract Background: Central intraductal papilloma (IDP) has a low risk of cancer evolution; therefore, surgical treatment of IDP is controversial. We sought to validate ultrasound (US)-guided percutaneous microwave ablation (MWA) for minimally invasive treatment of IDP. Methods: Thirteen women with central IDP, including six with nipple discharge, underwent US-guided core needle biopsy and MWA from December 2016 to November 2017. Lesions histologically diagnosed as benign IDP were included. The hydro-dissection technique was used to protect the nipple d...
Source: International Journal of Hyperthermia - June 11, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Conformal coverage of liver tumors by the thermal coagulation zone in 2450-MHz microwave ablation.
Conclusion: The proposed method can be applied to computer-assisted MWA treatment planning of liver tumors, and is expected to guide clinical procedures in future. PMID: 31172824 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 8, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The impact of whole-body hyperthermia interventions on mood and depression - are we ready for recommendations for clinical application?
Conclusion: WBH is a promising alternative treatment for depression with low risk for adverse reactions and side effects but still lacking sufficient evidence for general recommendations for clinical practice. However, as all other interventions have failed, the studies to date can provide a framework for clinical application. PMID: 31159624 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 5, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The effect of high-intensity focused ultrasound guided by magnetic resonance therapy on obstetrical outcomes in patients with uterine fibroids - experiences from the main Polish center and a review of current data.
Conclusions: MRgFUS/MR-HIFU seems to be an interesting minimally invasive alternative for women with UFs who wish to conceive and deliver after the procedure. This method does not increase the rate of spontaneous abortions or pregnancy complications. In our opinion, it is important to take off an unjustified badge stating that MRgFUS/MR-HIFU method is contraindicated in women with UFs who wish to conceive. PMID: 31159642 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 5, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Efficacy of hyperthermic intraperitoneal chemotherapy in patients with epithelial ovarian cancer: a meta-analysis.
Conclusions: HIPEC is associated with improved OS and PFS in both primary and recurrent EOC. However, no significant increased 1- and 2-year of PFS were reached in recurrent EOC treated with HIPEC. Further prospective randomized controlled trials are warranted. PMID: 31137989 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 31, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

2018 Editor's award winners.
Authors: PMID: 31130011 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 29, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Experimental assessment on feasibility of computed tomography-based thermometry for radiofrequency ablation on tissue equivalent polyacrylamide phantom.
Conclusion: CT thermometry is feasible for temperature assessment during RFA with the current CT technology, which produced a high CT number reproducibility and stable measurement at different CT acquisition parameters. Despite being affected by metal artifacts, the CT-based thermometry could be further developed as a tissue temperature monitoring tool during CT-guided thermal ablation. PMID: 31132888 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 29, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Magnetic hyperthermia adjunctive therapy for fungi: in vitro studies against Candida albicans.
Authors: Suneet K, Sridhar S, Agiwal P, Sridhar MS, Sanyal K, Jain S Abstract The poor penetration of anti-fungal agents into the cornea through the intact epithelium layer makes it difficult to treat acute fungal corneal infections. Herein, we developed Amphotret (amphotericin B) antifungal drug contained polycaprolactone-Fe3O4 (PCL-FO) magnetic nanofibers (MNFs) using the electrospinning technique. These MNFs generate heat in the presence of AC magnetic field (AMF) and release drug upon heating. MNFs were compatible with human mesenchymal stem cells (hMSCs) and HeLa cells, which exhibited unaltered proliferation,...
Source: International Journal of Hyperthermia - May 29, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Mid-term results of MR-guided high-intensity focused ultrasound treatment for relapsing superficial desmoids.
CONCLUSION: MR-HIFU shows good mid-term result for extra-abdominal desmoids with complete response for small lesions and stabilization of larger lesions. MR-HIFU for desmoids can be performed under regional anesthesia/sedation as outpatients. PMID: 31068030 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 11, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Beneficial impact of microwave ablation-assisted laparoscopic hepatectomy in cirrhotic hepatocellular carcinoma patients: a propensity score matching analysis.
CONCLUSIONS: MLH significantly decreased intraoperative bleeding and reduced the need for hepatic occlusion without compromising the surgical outcome. Therefore, microwave ablation could be a valuable tool for LH in HCC patients with cirrhosis. PMID: 31066585 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 9, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Tissue-mimicking thermochromic phantom for characterization of HIFU devices and applications.
CONCLUSIONS: We developed a novel MR-imageable and HIFU-compatible TMTCP to characterize HIFU heating without MRI or thermocouples. The HIFU-optimized TMTCP reports absolute temperatures and ablation zone geometry with high spatial resolution. Consequently, the TMTCP can be used to evaluate HIFU heating and may provide an in vitro tool for peak temperature assessment, and reduce preclinical in vivo requirements for clinical translation. PMID: 31046513 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 4, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Heat risks associated with synthetic athletic fields.
Authors: Abraham J PMID: 31018722 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 26, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Targeting autophagy enhances heat stress-induced apoptosis via the ATP-AMPK-mTOR axis for hepatocellular carcinoma.
CONCLUSIONS: Heat stress induced protective autophagy against heat-induced apoptosis in HCC via the ATP-AMPK-mTOR axis, suggesting that targeting autophagy may be a promising strategy for improving the efficacy of RFA treatment for HCC. PMID: 31007109 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 24, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis.
CONCLUSIONS: The combined therapeutic regimen of HIFU, GnRH-a and LNS-IUS is safe, effective and efficient for curing severe adenomyosis. PMID: 30994010 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 19, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

BRAF status as a predictive factor for response in isolated limb perfusion.
CONCLUSION: In this consecutive series of patients, BRAF V600E/K mutation was not found to be a significant factor for response or survival following ILP. PMID: 30987478 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 18, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Predictive value of SAR based quality indicators for head and neck hyperthermia treatment quality.
CONCLUSION: Our investigation confirmed the validity of our current strategy for deep hyperthermia in the head & neck based on a combination of THQ and TC25. TC50 was identified as the best surrogate since it enables optimization and patient inclusion decision making using one single parameter. PMID: 30973030 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 12, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Real-time monitoring radiofrequency ablation using tree-based ensemble learning models.
CONCLUSIONS: It is shown that an optimal pair of hardware setup and ML algorithm (Adaboost) is able to control the ablation by estimating the lesion depth within a test average of 0.3mm while keeping the estimation time within 10ms on a ×86-64 workstation. PMID: 30939953 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 5, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Assessment of nephrotoxicity associated with combined cisplatin and mitomycin C usage in laparoscopic hyperthermic intraperitoneal chemotherapy.
CONCLUSION: The laparoscopic approach to HIPEC using both cisplatin and MMC in our cohort was not associated with an increased incidence of AKI. The incidence of hypophosphatemia and hypocalcemia needs further evaluation to determine the exact etiology. Precis' statement: We retrospectively studied the association of AKI with the combined use of cisplatin and MMC in laparoscopic HIPEC. PMID: 30935256 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 4, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Feasibility study of metabolically supported chemotherapy with weekly carboplatin/paclitaxel combined with ketogenic diet, hyperthermia and hyperbaric oxygen therapy in metastatic non-small cell lung cancer.
CONCLUSIONS: Findings of this study suggest that MSCT combined with other modalities targeting multiple pathways and cellular vulnerabilities may bring about remarkable improvements in survival outcomes and treatment response rates in metastatic NSCLC, without additional safety concerns. Large comparative studies are warranted to draw robust conclusions. PMID: 30931666 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 2, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients.
CONCLUSIONS: In conclusion, we conducted a retrospective study combining mFOLFIRINOX and DRHT, which was well tolerated. The efficacy in the treatment of pancreatic cancer was encouraging, but further studies would be required to prove its merit, compared with conventional treatment. PMID: 30917701 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 30, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

2016 Editor's award winners.
Authors: PMID: 30919715 [PubMed] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 30, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Correction to: Liu, Zhang, Han, Zhang, Zhang, Qi, Yu, Li, Su, Duan, Li, Effectiveness of ultrasound-guided percutaneous microwave ablation for symptomatic uterine fibroids: a multicentre study in China.
Authors: PMID: 30919716 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 30, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The impact of technical parameters on ablation volume during MR-guided focused ultrasound of desmoid tumors.
Authors: Bucknor MD, Beroukhim G, Rieke V, Ozhinsky E, Lobach I Abstract PURPOSE: Desmoid tumors are benign, locally aggressive soft tissue tumors derived from fibroblasts. Magnetic resonance-guided focused ultrasound (MRgFUS) is a safe and effective treatment for desmoid tumors. The purpose of this study was to retrospectively review the MRgFUS treatments of desmoid tumors at our institution to determine which technical treatment parameters contributed most significantly to the accumulation of thermal dose. MATERIALS AND METHODS: The study protocol was approved by the local IRB. We retrospectively reviewed dat...
Source: International Journal of Hyperthermia - March 30, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Real-time optoacoustic temperature determination on cell cultures during heat exposure: a feasibility study.
CONCLUSIONS: This method shows great potential not only as a noninvasive, non-contact method to determine temperature/time responses of cells in culture, but also for complex tissue and other materials. PMID: 30922131 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 30, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Correction.
Authors: PMID: 30922132 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 30, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Reactivation of heat-inactivated Ku proteins by heat shock cognate protein HSC73.
CONCLUSIONS: These results suggest that de novo protein synthesis is unnecessary for recovery of some heat-inactivated DNA-PK. Rather, it might be reactivated by the molecular chaperone activity of HSC73, but not HSP72. PMID: 30922135 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 30, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Reasons for different therapeutic effects of high-intensity focused ultrasound ablation on excised uterine fibroids with different signal intensities on T2-weighted MRI: a study of histopathological characteristics.
CONCLUSIONS: Differences in histopathological characteristics may be one of the reasons for different therapeutic effects of HIFU ablation on uterine fibroids with different signal intensities on T2-weighted MRI. PMID: 30915864 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 29, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Proteomic and bioinformatic analysis of condyloma acuminata: mild hyperthermia treatment reveals compromised HPV infectivity of keratinocytes via regulation of metabolism, differentiation and anti-viral responses.
CONCLUSIONS: Hyperthermia inhibited enzymes and molecules responsible for metabolism modulation and keratinocyte differentiation in CA tissue, whereas it promoted factors involved in anti-viral responses. Such effects may, in part, contribute to the efficacy of local hyperthermia therapy against HPV infection. PMID: 30909744 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 27, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Minimally-invasive treatments for benign thyroid nodules: a Delphi-based consensus statement from the Italian minimally-invasive treatments of the thyroid (MITT) group.
Authors: Papini E, Pacella CM, Solbiati LA, Achille G, Barbaro D, Bernardi S, Cantisani V, Cesareo R, Chiti A, Cozzaglio L, Crescenzi A, De Cobelli F, Deandrea M, Fugazzola L, Gambelunghe G, Garberoglio R, Giugliano G, Luzi L, Negro R, Persani L, Raggiunti B, Sardanelli F, Seregni E, Sollini M, Spiezia S, Stacul F, Van Doorne D, Sconfienza LM, Mauri G Abstract Benign thyroid nodules are a common clinical occurrence and usually do not require treatment unless symptomatic. During the last years, ultrasound-guided minimally invasive treatments (MIT) gained an increasing role in the management of nodules causing local ...
Source: International Journal of Hyperthermia - March 27, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Letter to the editor regarding perivascular extension of microwave ablation zone.
Authors: Ma G, Ding Z, Huang H, Zhou W, Wang S PMID: 30912453 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 27, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

In response to letter to the editor from Ma et  al. 2019 regarding perivascular extension of microwave ablation zone.
In response to letter to the editor from Ma et al. 2019 regarding perivascular extension of microwave ablation zone. Int J Hyperthermia. 2019 Mar 23;:1 Authors: Singh S, Siriwardana PN, Johnston EW, Watkins J, Bandula S, Illing RO, Davidson BR PMID: 30905224 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 26, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Cryo-thermal therapy inducing MI macrophage polarization created CXCL10 and IL-6-rich pro-inflammatory environment for CD4+ T cell-mediated anti-tumor immunity.
CONCLUSIONS: Cryo-thermal-induced CXCL10 and IL-6 created acute inflammatory environment to initiate a systemically cascading innate and adaptive anti-tumor immunity, which was more permissive for tumor eradication. PMID: 30892102 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 22, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

High-intensity focused ultrasound combined procedures treatment of retained placenta accreta with marked vascularity after abortion or delivery.
This study included 21 patients diagnosed with retained PA with marked vascularity after abortion or delivery from July 2015 to December 2017. Patients with high serum β-hCG level (≥100 mIU/mL) received systemic MTX + HIFU treatment for 3 days and the ones with low β-hCG level (
Source: International Journal of Hyperthermia - March 22, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave ablation of hyperplastic parathyroid glands is a treatment option for end-stage renal disease patients ineligible for surgical resection.
Authors: Zhuo L, Zhang L, Peng LL, Yang Y, Lu HT, Chen DP, Li WG, Yu MA Abstract BACKGROUND: Secondary hyperparathyroidism (SHPT) is a frequently encountered problem in patients with end-stage renal disease (ESRD). Some patients with severe SHPT could not be managed by medical treatment and are ineligible for surgical resection. PURPOSE: Our objective was to evaluate the efficacy, safety of microwave ablation (MWA) on these patients. MATERIALS AND METHODS: Between 1 April 2015 and 28 February 2017, 35 patients (M/F 19/16, age 49.8 ± 12.9 years) were enrolled. All patients were tr...
Source: International Journal of Hyperthermia - March 10, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results.
Authors: Xu C, Li L, Xu W, Du C, Yang L, Tong J, Yi Y Abstract OBJECTIVE: The aims of this study were to compare the clinical outcomes between ultrasound-guided percutaneous microwave ablation (US-PMWA) and surgical resection (SR) in patients with recurrent intrahepatic cholangiocarcinoma (ICC) and to identify the prognostic factors associated with the two treatment methods. METHODS: This retrospective study was institutional review board approved. A total of 121 patients (102 men and 19 women) with 136 ICCs after hepatectomy from April 2011 to January 2017 were reviewed. Fifty-six patients underwent US-PMWA an...
Source: International Journal of Hyperthermia - March 10, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

An assessment of the survival impact of multimodal anesthesia/analgesia technique in adults undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: a propensity score matched analysis.
The objective of this single institution retrospective study was to evaluate the survival impact of a multimodal opioid-sparing nonvolatile anesthetic technique (MA) in a group of patients who had undergone cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) for appendiceal carcinomatosis. METHODS: Propensity score matching (PSM) and Cox proportional hazard models were used to compare the survivals of patients who received MA (MA group), to those who received volatile-opioid anesthesia (volatile-opioid group). RESULTS: Of the 373 patients, 110 (29%) were in the MA group and 263 (71%) in...
Source: International Journal of Hyperthermia - March 6, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Intraperitoneal perfusion chemotherapy and whole abdominal hyperthermia using external radiofrequency following radical D2 resection for treatment of advanced gastric cancer.
CONCLUSIONS: This hypothesis-generating study indicated that IP chemotherapy with whole abdominal hyperthermia might be feasible for gastric cancer patients after D2 resection. PMID: 30829551 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 6, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison of temperature change and resulting ablation size induced by a 902-928  MHz and a 2450 MHz microwave ablation system in in-vivo porcine kidneys.
CONCLUSION: The 2450 MHz system achieved similar steady state temperature increases compared to the 902-928 MHz system, but more quickly due to higher output power. Further investigations using various treatment parameters and precise thermal sensor placement are warranted to refine equation parameters for the development of an ablation model. PMID: 30836034 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 6, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison of efficacy and complications between radiofrequency ablation and repeat surgery in the treatment of locally recurrent thyroid cancers: a single-center propensity score matching study.
Authors: Choi Y, Jung SL, Bae JS, Lee SH, Jung CK, Jang J, Shin NY, Choi HS, Ahn KJ, Kim BS Abstract PURPOSE: To compare the efficacy and complication rates of radiofrequency ablation (RFA) and repeat surgery in the treatment of locally recurrent thyroid cancers. MATERIALS AND METHODS: A total of 221 patients with locally recurrent thyroid cancers who underwent either RFA (n = 96) or repeat surgery (n = 125) between March 2008 and March 2017 were retrospectively enrolled (range of follow-up, 1-10 years). Each cohort consisted of 70 patients after propensity score adjustment. P...
Source: International Journal of Hyperthermia - March 6, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Orthotopic hepatocellular carcinoma: molecular imaging-monitored intratumoral hyperthermia-enhanced direct oncolytic virotherapy.
This study included in vitro experiments using luciferase-labeled rat HCC cells and in vivo validation experiments on rat models with orthotopic HCCs. Both cells and HCCs in four groups (n = 6/group) were treated by: (1) combination therapy of oncolytic virotherapy (T-VEC) plus RFH at 42 °C for 30 min; (2) oncolytic virotherapy alone; (3) RFH alone; and (4) saline. For in vitro confirmation, confocal microscopy and bioluminescence optical imaging were used to evaluate the cell viabilities. For in vivo validation, oncolytic viruses were directly infused into rat HCCs through a multi-functiona...
Source: International Journal of Hyperthermia - February 20, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Safety and technical feasibility of percutaneous ablation for lymph node metastases of hepatocellular carcinoma.
CONCLUSION: Percutaneous ablation appears to be a safe and feasible method for treatment of metastatic LNs in patients with HCC. PMID: 30776925 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 20, 2019 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research