Feasibility of removable balloon implant for simultaneous magnetic nanoparticle heating and HDR brachytherapy of brain tumor resection cavities.
CONCLUSIONS: These preclinical results demonstrate the feasibility of using a TBT balloon to deliver heat simultaneously with HDR brachytherapy to tumor bed around a brain tumor resection cavity, with significantly improved uniformity of heating over previous multi-catheter interstitial approaches. Considered along with results of previous clinical thermobrachytherapy trials, this new capability is expected to improve both survival and quality of life in patients with glioblastoma multiforme. PMID: 33047639 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 15, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The impact of HIPEC vs. EPIC for the treatment of mucinous appendiceal carcinoma: a study from the US HIPEC collaborative.
Authors: Leiting JL, Day CN, Harmsen WS, Cloyd JM, Abdel-Misih S, Fournier K, Lee AJ, Dineen S, Dessureault S, Veerapongh J, Baumgartner JM, Clarke C, Mogal H, Russell MC, Zaidi MY, Patel SH, Morris MC, Hendrix RJ, Lambert LA, Abbott DE, Pokrzywa C, Raoof M, Eng O, Johnston FM, Greer J, Grotz TE Abstract INTRODUCTION: Mucinous appendiceal carcinoma is a rare malignancy that commonly spreads to the peritoneum leading to peritoneal metastases. Complete cytoreduction with perioperative intraperitoneal chemotherapy (PIC) is the mainstay of treatment, administered as either hyperthermic intra peritoneal chemotherapy (HI...
Source: International Journal of Hyperthermia - October 14, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Factors associated with health-related quality of life in papillary thyroid microcarcinoma patients undergoing radiofrequency ablation: a cross-sectional prevalence study.
CONCLUSIONS: The factors related to significantly worse HRQoL scores across PCS and MCS for PTMC survivors include the female gender, the symptoms of neuromuscular and the throat/mouth, the psychological disorder, inability to concentrate, and the fear of their own physical health. Identification, management, and prevention of these factors are critical to improving the HRQoL of patients. PMID: 33043742 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 14, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Characterization of magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU)-induced large-volume hyperthermia in deep and superficial targets in a porcine model.
CONCLUSION: Large-volume MRgHIFU-mediated HT was successfully implemented and characterized in a porcine model in deep and superficial targets in vivo with heating distributions modifiable by user-definable parameters. PMID: 33003967 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 4, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Residual vital ratio: predicting regrowth after radiofrequency ablation for benign thyroid nodules.
Authors: Yan L, Luo Y, Xie F, Zhang M, Xiao J Abstract PURPOSE: To determine a novel quantitative index, residual vital ratio(RVR) by contrast-enhanced ultrasound(CEUS) with conventional Ultrasound(US), to early predict nodule regrowth after radiofrequency ablation (RFA)for benign thyroid nodules. METHODS: This retrospective study evaluated 186 patients with 206 benign thyroid nodules underwent RFA. Patients were followed at 1, 3, 6, 12 months and every 12 months thereafter by conventional US, CEUS and clinical evaluation. RVR was defined as the initial ratio of residual vital volume to the total volume ...
Source: International Journal of Hyperthermia - October 2, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

How large is the periablational zone after radiofrequency and microwave ablation? Computer-based comparative study of two currently used clinical devices.
Authors: Trujillo M, Prakash P, Faridi P, Radosevic A, Curto S, Burdio F, Berjano E Abstract PURPOSE: To compare the size of the coagulation (CZ) and periablational (PZ) zones created with two commercially available devices in clinical use for radiofrequency (RFA) and microwave ablation (MWA), respectively. METHODS: Computer models were used to simulate RFA with a 3-cm Cool-tip applicator and MWA with an Amica-Gen applicator. The Arrhenius model was used to compute the damage index (Ω). CZ was considered when Ω > 4.6 (>99% of damaged cells). Regions with 0.6
Source: International Journal of Hyperthermia - October 2, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Intraprocedurally EOB-MRI/US fusion imaging focusing on hepatobiliary phase findings can help to reduce the recurrence of hepatocellular carcinoma after radiofrequency ablation.
CONCLUSIONS: The intraprocedurally application of EOB-MRI/US FI to determine ablation scope according to HBP findings is feasible and beneficial for prognosis of RFA. PMID: 32996799 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 2, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Effects of energy-based ablation on thyroid function in treating benign thyroid nodules: a systematic review and meta-analysis.
CONCLUSIONS: Energy-based ablation was more likely to have negative effects on thyroid function and antibodies and led to transient increase in Tg level in the short term. However, most of the patients would not develop any thyroid dysfunction in the long-term follow-up. PMID: 32981370 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 1, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A multi-institution study: comparison of the heating patterns of five different MR-guided deep hyperthermia systems using an anthropomorphic phantom.
CONCLUSION: Anthropomorphic phantoms were used to perform QA-measurements of MR-guided hyperthermia systems operating in MR-scanners of different brands. Comparable heating profiles are shown for the five evaluated institutions. Subcentimeter differences in position substantially affected the results when evaluating the heating patterns. Integration of advanced phantoms and precise positioning in QA-guidelines should be evaluated to guarantee the best quality patient care. PMID: 32981391 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 1, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Enhancement of HIFU thermal therapy in perfused tissue models using micron-sized FTAC-stabilized PFOB-core endovascular sonosensitizers.
CONCLUSION: The current PFOB-FTAC micro-droplet sonosensitizers provided a large and sustained enhancement of the HIFU thermal deposition at the focal area, suggesting solutions for less technological constraints, lower risk for the near-/far- field heating. We also report a suitable experimental model for other MRgHIFU studies. PMID: 32990101 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 1, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Efficacy and safety of single-session radiofrequency ablation for benign thyroid nodules of different sizes: a retrospective study.
CONCLUSIONS: RFA was confirmed as effective in patients with large thyroid nodule (>30ml), with therapeutic efficacy similar to patients with smaller thyroid nodules. PMID: 32964743 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 25, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Stereotactic radiofrequency ablation of a variety of liver masses in children.
CONCLUSIONS: SRFA is an effective minimal-invasive treatment option in pediatric patients with liver tumors of different etiologies. PMID: 32954876 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 22, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Quantitative dynamic contrast-enhanced ultrasound to predict intrahepatic recurrence of hepatocellular carcinoma after radiofrequency ablation: a cohort study.
CONCLUSION: CEUS is commonly used in HCC patients who undergo RFA. The CEUS parameters PI and TTP are associated with intrahepatic recurrence after RFA, and can thus be used to identify patients at risk for intrahepatic recurrence. PMID: 32924654 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 15, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

High intensity focused ultrasound treatment for diffuse uterine leiomyomatosis: a feasibility study.
CONCLUSION: HIFU treatment is safe and effective in the treatment of patients with DUL. PMID: 32892661 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 9, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The effect of injected dose on localized tumor accumulation and cardiac uptake of doxorubicin in a Vx2 rabbit tumor model using MR-HIFU mild hyperthermia and thermosensitive liposomes.
Conclusions: These results provide guidance on clinical protocol design of hyperthermia-triggered drug delivery. PMID: 32892667 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 9, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Long-term follow-up outcome and reintervention analysis of ultrasound-guided high intensity focused ultrasound treatment for uterine fibroids.
CONCLUSION: USgHIFU for uterine fibroids is effective due to low reintervention rate in a long-term follow-up. PMID: 32878497 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 5, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Prediction of pelvic tumour coverage by magnetic resonance-guided high-intensity focused ultrasound (MRgHIFU) from referral imaging.
CONCLUSION: Prediction of MRgHIFU target coverage from referral imaging appears feasible, facilitating further development of automated evaluation of patient suitability for MRgHIFU. PMID: 32873089 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 4, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

High-intensity focused ultrasound (HIFU) for the treatment of uterine fibroids: does HIFU significantly increase the risk of pelvic adhesions?
CONCLUSIONS: Based on our results with limited numbers, we concluded that HIFU treatment did not significantly increase the risk of pelvic adhesions. PMID: 32873107 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 4, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Contrast-enhanced ultrasound-guided feeding artery ablation as add-on to percutaneous radiofrequency ablation for hypervascular hepatocellular carcinoma with a modified ablative technique and tumor perfusion evaluation.
CONCLUSION: As an add-on to conventional percutaneous RFA, tailored CEUS-guided FAA can reduce tumor perfusion and provide good local control of HCC. PMID: 32865050 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 2, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Prolonged post-ablation fever may predict one-year tumor recurrence in hepatocellular carcinoma after radiofrequency ablation.
CONCLUSIONS: Prolonged PAF may associate with early HCC recurrence after complete ablation by RFA. Patients with prolonged PAF need to be more clinical attentions. PMID: 32814458 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - August 22, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Advanced patient-specific hyperthermia treatment planning.
Authors: Gavazzi S, van Lier ALHMW, Zachiu C, Jansen E, Lagendijk JJW, Stalpers LJA, Crezee H, Kok HP Abstract Hyperthermia treatment planning (HTP) is valuable to optimize tumor heating during thermal therapy delivery. Yet, clinical hyperthermia treatment plans lack quantitative accuracy due to uncertainties in tissue properties and modeling, and report tumor absorbed power and temperature distributions which cannot be linked directly to treatment outcome. Over the last decade, considerable progress has been made to address these inaccuracies and therefore improve the reliability of hyperthermia treatment planning...
Source: International Journal of Hyperthermia - August 20, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Clinical outcomes of curative treatment for colorectal liver metastases combined with cytoreductive surgery and intraperitoneal chemotherapy for peritoneal metastases: a systematic review and meta-analysis of current evidence.
Authors: Zou Y, Chen X, Zhang X, Shen Z, Cai J, Tan Y, Weng J, Rong Y, Lin X Abstract BACKGROUND: The optimal treatment for colorectal cancer (CRC) with synchronous peritoneal carcinomatosis (PC) and liver metastases (LM) remains controversial. We aimed to investigate clinical outcomes in patients with CRC and concomitant PC and LM who had undergone curative surgery, including resections at both metastatic sites and synchronous intraabdominal chemotherapy. METHODS: We searched PubMed, EMBASE, and Web of Science databases for eligible studies. Studies focusing on the clinical effects of curative surgery and sync...
Source: International Journal of Hyperthermia - August 15, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Disseminated peritoneal leiomyomatosis after uterine artery embolization, laparoscopic surgery, and high intensity focused ultrasound for uterine fibroids :a case report.
CONCLUSION: In our case, the occurrence of DPL is most likely associated with laparoscopic myomectomy using power morcellation. In addition, it should be noted whether some other factors played a role in stimulating the growth of the multiple nodules. PMID: 32752969 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - August 13, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

mNP hyperthermia and hypofractionated radiation activate similar immunogenetic and cytotoxic pathways.
CONCLUSION: This study clearly shows that modest, but commonly used hypofractionated radiation and hyperthermia doses share many important immune and cytotoxic pathways and that combining the treatments, as compared to either treatment alone, results in genetic and biological anti-cancer benefits. PMID: 32757666 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - August 13, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave ablation versus transcatheter arterial embolization for large hepatic hemangiomas: clinical outcomes.
Authors: Shi Y, Song J, Ding M, Tang X, Wang Z, Chi J, Wang T, Ji J, Zhai B Abstract PURPOSE: To evaluate the safety and effect of microwave ablation (MWA) compared with transcatheter arterial embolization (TAE) for the treatment of large hepatic hemangiomas. MATERIALS AND METHODS: A total of 135 patients with symptomatic or/and enlarging hepatic hemangiomas (5-10 cm) from two centers underwent either MWA (n = 82) or TAE (n = 53) as first-line treatment. We compared the two groups in terms of radiologic response, clinical response, operative time, postoperative analgesic requi...
Source: International Journal of Hyperthermia - August 13, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided percutaneous microwave ablation for hepatocellular carcinoma adjacent to large vessels: a propensity score matching analysis.
CONCLUSIONS: Ultrasound-guided percutaneous MWA appears to be a safe procedure and can achieve comparable oncological efficacy for HCC abutting large vessels. PMID: 32781862 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - August 13, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Exploring the potential of the dynamic hysteresis loops via high field, high frequency and temperature adjustable AC magnetometer for magnetic hyperthermia characterization.
CONCLUSION: We show that AC magnetometry becomes a very reliable technique to determine the effective anisotropy constant of single domains, to study the impact of the mechanical orientation in the SAR and to choose the optimal excitation parameters to maximize heating production under human safety limits. PMID: 32781865 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - August 13, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Serial locally applied water-filtered infrared a radiation in axial spondyloarthritis - a randomized controlled trial.
Authors: Klemm P, Eichelmann M, Aykara I, Hudowenz O, Dischereit G, Lange U Abstract INTRODUCTION: Aim of this randomized controlled trial was to evaluate the effects of serial locally applied water-filtered infrared A radiation (sl-wIRAR) in patients with axial spondyloarthritis (axSpA). METHODS: axSpA patients with active disease undergoing a 7-day multimodal rheumatologic complex treatment under non-steroidal anti-inflammatory drug (NSAID) therapy were eligible. Patients were randomly assigned in a 1:1 ratio. The intervention group (IG) received additional sl-wIRAR treatment of the back (2 treatments for 30&...
Source: International Journal of Hyperthermia - August 13, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Efficacy and safety of percutaneous ultrasound-guided microwave ablation for cervical metastatic lymph nodes from papillary thyroid carcinoma.
CONCLUSIONS: US-guided MWA can effectively control cervical metastatic lymph nodes from PTC. MWA may become an alternative therapy in selected PTC patients with cervical lymph node metastasis. PMID: 32781871 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - August 13, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison of thermal ablation and routine surgery for the treatment of papillary thyroid microcarcinoma: a systematic review and Meta-analysis.
CONCLUSIONS: TA may not be oncologically inferior to RS, and it is a relatively safe and economical alternative for the treatment of PTMC. PMID: 32722973 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 30, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Safety and feasibility of arterial wall targeting with robot-assisted high intensity focused ultrasound: a preclinical study.
CONCLUSION: HIFU/DMUA therapy successfully targeted the vessel walls of healthy porcine arteries, without causing endothelial damage or other vascular complications. Therefore, this therapy can be safely applied to healthy arterial walls in animals. Future studies should focus on safety and dose-finding in atherosclerotic diseased arteries. PMID: 32713277 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 29, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Lung microwave ablation - an in  vivo swine tumor model experiment to evaluate ablation zones.
Lung microwave ablation - an in vivo swine tumor model experiment to evaluate ablation zones. Int J Hyperthermia. 2020;37(1):879-886 Authors: Prud'homme C, Teriitehau C, Adam J, Kyaw Tun J, Roux C, Hakime A, Delpla A, Deschamps F, de Baere T, Tselikas L Abstract PURPOSE: To evaluate microwave ablation (MWA) algorithms, comparing pulsed and continuous mode in an in vivo lung tumor mimic model. MATERIALS AND METHODS: A total of 43 lung tumor-mimic models of 1, 2 or 3 cm were created in 11 pigs through an intra-pulmonary injection of contrast-enriched minced muscle. Tumors were ablate...
Source: International Journal of Hyperthermia - July 23, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Bifidobacterium-mediated high-intensity focused ultrasound for solid tumor therapy: comparison of two nanoparticle delivery methods.
CONCLUSION: Delivery of B. longum followed by that of PFH/BL-NPs can enhance the imaging of solid tumors and effectively improve the efficiency of HIFU treatment of solid tumors, providing a basis for further clinical work. PMID: 32689830 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 23, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

wIRA-heating of piglet skin and subcutis in  vivo: proof of accordance with ESHO criteria for superficial hyperthermia.
CONCLUSIONS: Piglet data are comparable with preliminary literature data assessed in vivo in the abdominal wall and in recurrent breast cancer of humans. The potential of wIRA-HT for adequate treatment of superficial tissues/cancers in the clinical setting thus is confirmed. To ensure therapeutically needed doses of wIRA-HT, irradiation times should be extended. PMID: 32689831 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 23, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Sodium thiosulfate protects from renal impairement following hyperthermic intraperitoneal chemotherapy (HIPEC) with Cisplatin.
Authors: Laplace N, Kepenekian V, Friggeri A, Vassal O, Ranchon F, Rioufol C, Gertych W, Villeneuve L, Glehen O, Bakrin N Abstract BACKGROUND: Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has been shown to provide benefits in the management of peritoneal metastasis. Cisplatin (CDDP) is one of the most frequently used drugs for peritoneal infusion. A major restriction is that CDDP causes renal toxicity and acute renal failure, sometimes leading to chronic renal failure. The aim of the present study was to assess the impact of sodium thiosulfate (ST) in preventing renal impair...
Source: International Journal of Hyperthermia - July 23, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Editors' awardees for 2020.
Authors: Dewhirst M PMID: 32686534 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 21, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Safety and efficacy of intravesical chemotherapy and hyperthermia in the bladder: results of a porcine study.
CONCLUSIONS: Convective bladder hyperthermia using the Combat BRS device is safe and the temperature can be maintained at 43 °C. Hyperthermia therapy may increase MMC penetration into the bladder wall but does not result in an increase of MMC levels in other organs. PMID: 32664768 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Percutaneous radiofrequency ablation of HCC: reduced ablation duration and increased ablation size using single, internally cooled electrodes with an optimized pulsing algorithm.
CONCLUSION: Efficient delivery of RF energy can considerably decrease the ablation time in many instances while achieving larger, relatively spherical, and reproducible areas of ablation with extremely low rates of local tumor progression and adverse events. PMID: 32669003 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Emerging indications for stereotactic laser interstitial thermal therapy in pediatric neurosurgery.
Authors: Remick M, McDowell MM, Gupta K, Felker J, Abel TJ Abstract Surgical treatment of deep or difficult to access lesions represents a unique and significant challenge for pediatric neurosurgeons. The introduction of stereotactic magnetic resonance-guided laser interstitial thermal therapy (LITT) over the last decade has had a dramatic impact on the landscape of pediatric neurosurgery. LITT provides a safe and effective option for children with epilepsy from hypothalamic hamartoma that represents a ground-breaking new therapy for a condition which was historically very difficult to treat with previous neurosurg...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The effect of thermal therapy on the blood-brain barrier and blood-tumor barrier.
Authors: Patel B, Yang PH, Kim AH Abstract The blood-brain and blood-tumor barriers represent highly specialized structures responsible for tight regulation of molecular transit into the central nervous system. Under normal circumstances, the relative impermeability of the blood-brain barrier (BBB) protects the brain from circulating toxins and contributes to a brain microenvironment necessary for optimal neuronal function. However, in the context of tumors and other diseases of central nervous system, the BBB and the more recently appreciated blood-tumor barrier (BTB) represent barriers that prevent effective drug...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Laser interstitial thermal therapy for treatment of cerebral radiation necrosis.
Authors: Hong CS, Beckta JM, Kundishora AJ, Elsamadicy AA, Chiang VL Abstract Radiation necrosis is a well described complication after radiosurgical treatment of intracranial pathologies - best recognized after the treatment of patients with arteriovenous malformations and brain metastases but possibly also affecting patients treated with radiosurgery for meningioma. The pathophysiology of radiation necrosis is still not well understood but is most likely a secondary local tissue inflammatory response to brain tissue injured by radiation. Radiation necrosis in brain metastases patients may present radiographically...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Introduction to laser thermal therapy for brain disorders.
Authors: Yu JS, Mohammadi AM PMID: 32672120 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Laser thermal therapy in the management of high-grade gliomas.
Authors: Avecillas-Chasin JM, Atik A, Mohammadi AM, Barnett GH Abstract Laser interstitial thermal therapy (LITT) is a minimally invasive therapy that have been used for brain tumors, epilepsy, chronic pain, and other spine pathologies. This therapy is performed under imaging and stereotactic guidance to precisely direct the probe and ablate the area of interest using real-time magnetic resonance (MR) thermography. LITT has gained popularity as a treatment for glioma because of its minimally invasive nature, small skin incision, repeatability, shorter hospital stay, and the possibility of receiving adjuvant therapy...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The use of laser interstitial thermal therapy in the treatment of brain metastases: a literature review.
CONCLUSIONS: The current literature supports LITT as a safe and effective therapy for patients with brain metastases that have failed SRS. Larger studies are still required to better evaluate the use of systemic therapy in concomitance with LITT. New images modalities may enable optimized treatment and outcomes. PMID: 32672122 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Hyperthermia treatment advances for brain tumors.
Authors: Skandalakis GP, Rivera DR, Rizea CD, Bouras A, Jesu Raj JG, Bozec D, Hadjipanayis CG Abstract Hyperthermia therapy (HT) of cancer is a well-known treatment approach. With the advent of new technologies, HT approaches are now important for the treatment of brain tumors. We review current clinical applications of HT in neuro-oncology and ongoing preclinical research aiming to advance HT approaches to clinical practice. Laser interstitial thermal therapy (LITT) is currently the most widely utilized thermal ablation approach in clinical practice mainly for the treatment of recurrent or deep-seated tumors in th...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Laser thermal therapy for epilepsy surgery: current standing and future perspectives.
Authors: Zemmar A, Nelson BJ, Neimat JS Abstract More than 130-year ago, Sir Victor Horsley delivered a landmark address to the British Medical Association, in which he described successful localization and resection of an epileptogenic focus resulting in seizure freedom for the patient. Several important steps in epilepsy surgery have been achieved since, including resection techniques such as anterior temporal lobectomy and selective amygdalohippocampectomy, both resulting in 70-80% seizure freedom and distinct differences in neuropsychological outcomes. The most recent addition to techniques for epilepsy surgery...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Cost-effectiveness of stereotactic laser ablation (SLA) for brain tumors.
CONCLUSION: There is limited data on the cost-effectiveness of SLA. In the available literature, SLA compared favorably to craniotomy in terms of cost-effectiveness as a treatment for primary and metastatic brain cancers. PMID: 32672125 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The intersection between immunotherapy and laser interstitial thermal therapy: a multipronged future of neuro-oncology.
Authors: Srinivasan ES, Sankey EW, Grabowski MM, Chongsathidkiet P, Fecci PE Abstract The rise of immunotherapy (IT) in oncological treatment has greatly improved outcomes in a number of disease states. However, its use in tumors of the central nervous system (CNS) remains limited for multiple reasons related to the unique immunologic tumor microenvironment. As such, it is valuable to consider the intersection of IT with additional treatment methods that may improve access to the CNS and effectiveness of existing IT modalities. One such combination is the pairing of IT with localized hyperthermia (HT) generated thr...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

In vitro evidence for glioblastoma cell death in temperatures found in the penumbra of laser-ablated tumors.
Authors: Frenster JD, Desai S, Placantonakis DG Abstract The concept of thermal therapy toward the treatment of brain tumors has gained traction in recent years. Traditionally, thermal therapy has been subdivided into hyperthermia, with mild elevation of temperature in treated tissue above the physiologic baseline; and thermal ablation, where even higher temperatures are achieved. The recent surge in interest has been driven by the use of novel thermal ablation technologies, including laser interstitial thermal therapy (LITT), that are implemented in brain tumor treatment. Here, we review previous scientific litera...
Source: International Journal of Hyperthermia - July 17, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Tumor-related HSP70 released after cryo-thermal therapy targeted innate immune initiation in the antitumor immune response.
CONCLUSIONS: Local cryo-thermal therapy not only destroyed solid tumors thermally and mechanically but also induced the release of a large amount of DAMPs to effectively trigger a systemic antitumor response. PMID: 32654540 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - July 14, 2020 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research