Validation of hybrid angular spectrum acoustic and thermal modelling in phantoms.
This study validates that using the HAS and PBHE method can adequately predict temperature profiles from single sonications in homogeneous media. Further, it informs the need to accurately measure or predict patient-specific properties for improved treatment planning of ablative FUS surgeries. PMID: 30320518 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 16, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Inducing intravesical hyperthermia of the ex-vivo porcine bladder wall: radiofrequency-induction versus recirculation using a custom-made device.
CONCLUSION: Our results indicate a slightly superior heating capacity for RF-HT compared to C-HT, whereas for the bladder dome, the reverse seems true. Comparative studies are warranted to evaluate whether HT efficacy differs between both techniques, with emphasis on tumor location. PMID: 30303406 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

An analysis of the survival impact of dexmedetomidine in children undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.
CONCLUSION: In this retrospective study of children and adolescents who had undergone a major oncologic surgery, the intraoperative and/or early postoperative administration of dexmedetomidine was not associated with survival. PMID: 30303410 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The effect of air pockets in the urinary bladder on the temperature distribution during loco-regional hyperthermia treatment of bladder cancer patients.
CONCLUSION: Presence of air causes more heterogeneous bladder wall temperatures and lower T90, particularly for larger air pockets. The size of air pockets must therefore be minimized during bladder hyperthermia treatments. PMID: 30303415 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Differences in serum IL-6 response after 1  °C rise in core body temperature in individuals with spinal cord injury and cervical spinal cord injury during local heat stress.
CONCLUSIONS: Under a similar increase in core temperature, ΔIL-6% was lower in the CSCI group compared with the AB group. These findings suggest that the observed rise in IL-6 during hyperthermia is mediated, at least in part, by plasma adrenaline. PMID: 30303416 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison of effectiveness of epidural analgesia and monitored anesthesia care for high-intensity focused ultrasound treatment of adenomyosis.
Authors: Lee CS, Lee JY, Ro S, Choi S, Moon JY Abstract BACKGROUND: High-intensity focused ultrasound (HIFU) is a noninvasive thermodestructive procedure targeting internal organs with concentrated sonification energy that may cause pain. We aimed to compare the effectiveness of epidural analgesia (EA) and monitored anesthesia care (MAC) in HIFU treatment of uterine adenomyosis. MATERIALS AND METHODS: Sixty-eight patients were included in this case-control study. Thirty-seven patients underwent MAC; 31 patients underwent fluoroscope-guided epidural analgesia. The primary outcome was a frequency of patients repo...
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Whole body heat exposure modulates acute glucose metabolism.
Authors: Kimball AL, McCue PM, Petrie MA, Shields RK Abstract AIM: Exercise modulates glucose tolerance and homeostasis in both healthy and diabetic individuals. Heat stress is a fundamental element of exercise. The acute glycemic response and alterations in glucose clearance following whole body passive heat stress in the absence of muscle activity has yet to be examined in humans. Knowledge of this relationship may prove useful, particularly in populations with compromised glucoregulation from reduced activity. PURPOSE: To determine insulin/glucose levels before and after an acute bout of heat stress in healt...
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Feasibility of targeting canine soft tissue sarcoma with MR-guided high-intensity focused ultrasound.
Authors: Seward MC, Daniel GB, Ruth JD, Dervisis N, Partanen A, Yarmolenko PS Abstract PURPOSE: Magnetic resonance imaging-guided high-intensity-focused ultrasound (MR-HIFU) is a non-invasive treatment modality that precisely focuses ultrasound energy within a tumour and can be customised to result in a wide range of local bioeffects. The purpose of this study was to determine the feasibility of using MR-HIFU to treat soft tissue sarcoma (STS) in dogs. MATERIALS AND METHODS: Medical records of dogs admitted to the Virginia-Maryland College of Veterinary Medicine from 1 January 2012 to 31 December 2016 were sear...
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A three-dimensional transient computational study of 532-nm laser thermal ablation in a geometrical model representing prostate tissue.
CONCLUSIONS: Laser thermal tissue ablation employing continuous wave mode lasers outperforms that employing pulsed mode lasers. Laser power settings should be carefully selected to maximize the rate of tissue ablation and minimize tissue coagulation. PMID: 30303431 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Changes in serum thyroglobulin and antithyroglobulin shortly following high-intensity focused ablation of benign thyroid nodules in patients with positive antithyroglobulin status.
CONCLUSIONS: Given the fact that the percentage anti-Tg drop correlated significantly with 6-month nodule shrinkage in group I, monitoring early anti-Tg change may help to predict the 6-month nodule shrinkage in patients with positive anti-Tg. PMID: 30303432 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A molecular dynamics approach towards evaluating osmotic and thermal stress in the extracellular environment.
CONCLUSION: Results quantify multiple measures of structural changes as a function of temperature increase and addition of NaCl to the solution. Correlations between cell viability and stability measures suggest that protein aggregates, non-functional proteins, and less favorable cell attachment conditions have a role in TCA-induced cell stress. PMID: 30303437 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

High intensity focused ultrasound treatment of adenomyosis: a comparative study.
Authors: Guo Q, Xu F, Ding Z, Li P, Wang X, Gao B Abstract OBJECTIVE: To compare the treatment efficacy and safety of high intensity focused ultrasound (HIFU) on its own, HIFU combined with levonorgestrel-releasing intrauterine system (LNG-IUS) and HIFU combined with gonadotropin-releasing hormone agonist (GnRHa). METHOD: Seventy-eight patients with adenomyosis who underwent HIFU treatment were retrospectively analyzed. Among them, 45 patients were treated only with HIFU, 15 patients were treated with HIFU combined with LNG-IUS and 18 patients were treated with HIFU combined with GnRHa. Dysmenorrhea scores, men...
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Magnetic resonance imaging features influencing high-intensity focused ultrasound ablation of adenomyosis with a nonperfused volume ratio of ≥90% as a measure of clinical treatment success: retrospective multivariate analysis.
Magnetic resonance imaging features influencing high-intensity focused ultrasound ablation of adenomyosis with a nonperfused volume ratio of ≥90% as a measure of clinical treatment success: retrospective multivariate analysis. Int J Hyperthermia. 2018 Oct 11;:1-11 Authors: Keserci B, Duc NM Abstract OBJECTIVE: This retrospective study aimed (1) to investigate the magnetic resonance imaging (MRI) features influencing a nonperfused volume ratio (NPVr) ≥ 90% after high-intensity focussed ultrasound (HIFU) ablation of adenomyosis, and (2) to assess the safety, which was defined in terms...
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Numerical analysis of thermal response of tissues subjected to high intensity focused ultrasound.
Authors: Gupta P, Srivastava A Abstract The present work is concerned with the numerical investigation of the thermal response of tissue-mimicking biological phantom(s) subjected to high intensity focused ultrasound (HIFU). Simulations have been performed on the 3-dimensional physical domain for two-layered as well as multi-layered medium consisting of water and liver tissue. Local pressure distribution within the body of the phantom has been calculated by solving the complete full-wave nonlinear form of Westervelt equation. The solution of the pressure wave equation has been coupled with Pennes bioheat transfer eq...
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Percutaneous image-guided ablation of bone metastases: local tumor control in oligometastatic patients.
CONCLUSIONS: Percutaneous image-guided locoregional therapies used in the radical treatment of BM in oligometastatic patients demonstrate significant rates of LPFS providing the size of BM ≤2 cm. PMID: 30307346 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Programmed death-ligand 1 expression and CD8+ tumor-infiltrating lymphocytes in advanced non-small cell lung cancer treated with microwave ablation and chemotherapy.
CONCLUSION: PD-L1 expression and the presence of CD8+ TILs could predict neither the patients' response to chemotherapy or MWA nor survival in advanced NSCLC patients treated with MWA plus chemotherapy. PMID: 30307348 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 13, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison between microwave ablation and bipolar radiofrequency ablation in benign thyroid nodules: differences in energy transmission, duration of application and applied shots.
Authors: Vorländer C, David Kohlhase K, Korkusuz Y, Erbelding C, Luboldt W, Baser I, Korkusuz H Abstract PURPOSE: Comparison between different thermal ablation systems for thyroid nodules regarding their different procedural characteristics such as treatment-time, number of shots and energy transmission in the context of their clinical performance such as complication rate and volume reduction after three months. METHODS: A total of 60 patients with 65 nodules underwent thermal ablation of thyroid nodules with either microwave ablation (MWA) (9 male, 15 female and mean age 57 ± 13&thin...
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Neoadjuvant chemotherapy plus radiation versus chemotherapy plus regional hyperthermia in high-grade soft tissue sarcomas: a retrospective comparison.
This study aims to compare preoperative CRT with neoadjuvant chemotherapy + regional hyperthermia (HCT) regarding histopathological response, toxicity and outcome. METHODS: In this retrospective analysis, 61 consecutive high-grade STS patients treated between 2009 and 2016 were included. All patients were treated within a prospective treatment protocol. 28 patients received neoadjuvant CRT 33 patients HCT. CRT consisted of four cycles doxorubicin/ifosfamide and two cycles ifosfamide concomitant to 50.4 Gray external beam radiotherapy. HCT consisted of 4-6 cycles doxorubicin/ifosfamide with deep regional h...
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave ablation followed by immediate biopsy in the treatment of non-small cell lung cancer.
CONCLUSIONS: Immediate biopsy post-MWA can distinguish cancer cells or histology types in most cases of NSCLC. However, pathology changes pre- and postablation could not predict the response to MWA and patient survival. PMID: 30300022 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Suppression of SESN1 reduces cisplatin and hyperthermia resistance through increasing reactive oxygen species (ROS) in human maxillary cancer cells.
CONCLUSIONS: This study demonstrated the participation of SESN1 in cisplatin and hyperthermia resistance of human head and neck cancers. SESN1 is a novel molecular target to overcome cisplatin resistance and hyperthermia resistance and improve head and neck cancer treatment. PMID: 30300027 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Predictive value of simulated SAR and temperature for changes in measured temperature after phase-amplitude steering during locoregional hyperthermia treatments.
CONCLUSION: Treatment planning can predict changes in an average temperature after phase-amplitude steering. This allows on-line support with phase-amplitude steering to optimize hyperthermia treatments. PMID: 30300028 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Treading the beaten path with old and new obstacles: a report from the Indian HIPEC registry.
CONCLUSIONS: These results validate existing practices and identify country-specific problems that need to be addressed. Despite operational problems, the registry is an invaluable tool for audit and research. It shows the feasibility of fruitful collaboration between surgeons in the absence of any regulatory body or funding for the project. PMID: 30300029 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Post-sauna recovery enhances brain neural network relaxation and improves cognitive economy in oddball tasks.
CONCLUSION: Post-sauna recovery to normothermia led to enhanced resting neural network relaxation followed by increases in cognitive processing economy for the given oddball tasks. The auditory processing was not affected more by post-sauna recovery than was visual processing. Post-sauna recovery modifications in ERP components (stimulus processing) were insufficient to affect cognitive performance in both visual and auditory task modalities. PMID: 30300030 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison of CT/MRI-CEUS and US-CEUS fusion imaging techniques in the assessment of the thermal ablation of liver tumors.
Authors: Xu E, Long Y, Li K, Zeng Q, Tan L, Luo L, Huang Q, Zheng R Abstract PURPOSE: To compare the applicability of fusion imaging between contrast-enhanced ultrasound (CEUS) and computed tomography (CT) or magnetic resonance imaging (MRI) (CT/MRI-CEUS fusion imaging) and fusion imaging between CEUS and ultrasound (US-CEUS fusion imaging) in the assessment of treatment response during liver cancer ablation. METHODS: From August to December 2015, patients who underwent US-guided thermal ablation of liver tumors at our hospital with available CT/MRI images were enrolled consecutively. Both CT/MRI-CEUS and US-CE...
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Multiple antenna placement in microwave ablation assisted by a three-dimensional fusion image navigation system for hepatocellular carcinoma.
CONCLUSIONS: The 3D FINS could be a safe, feasible and effective technique for guiding PMWA of HCC, which could help an operator improve the complete ablation rate of the first session. PMID: 30300036 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Quantitative dynamic contrast-enhanced ultrasound may help predict the outcome of hepatocellular carcinoma after microwave ablation.
CONCLUSION: DCE-US parameter may help predict the outcome of HCC patients after MWA, though further study is still needed. PMID: 30300039 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Upfront HIPEC and bevacizumab-containing adjuvant chemotherapy in advanced epithelial ovarian cancer.
CONCLUSION: Our data suggest that HIPEC can be safely introduced in the upfront therapy of advanced ovarian cancer. PMID: 30300042 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A clinically oriented computer model for radiofrequency ablation of hepatic tissue with internally cooled wet electrode.
CONCLUSIONS: Using a three-compartment model and a realistic saline spatial distribution notably improves the match with the outcome of the clinical trials. PMID: 30293464 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Local recurrence of brain metastasis reduced by intra-operative hyperthermia treatment.
CONCLUSIONS: Results of this study suggest that intra-operative hyperthermia treatment after total resection of metastatic brain tumor could reduce local recurrence of tumor. We believe that intra-operative hyperthermia treatment could be used as an adjuvant therapy to surgery and post-operative radiotherapy, or as a salvage treatment in patients who cannot receive further radiotherapy. PMID: 30293465 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Long-term survival in patients with epithelial ovarian cancer following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC).
The objective of the present study was to evaluate the frequency of long-term survivors and to identify the prognostic factors associated with long-term survival in a French cohort of 566 patients. METHODS: Patients treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for EOC in 13 French centers between 1991 and 2010 were included. Long-term survivors were defined as patients who survived more than 5 years after HIPEC and CRS, irrespective of relapse. RESULTS: Seventy-eight long-term survivors were analyzed. The median follow-up was 74 months. Median age at t...
Source: International Journal of Hyperthermia - October 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Efficacy of radio-hyperthermo-chemotherapy as salvage therapy for recurrent or residual malignant soft tissue tumors.
CONCLUSION: RHC is an effective option for salvage treatment of recurrent and residual STS. PMID: 30295115 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microbubble-assisted MRI-guided focused ultrasound for hyperthermia at reduced power levels.
Authors: Santos MA, Wu SK, Li Z, Goertz DE, Hynynen K Abstract PURPOSE: Ultrasound contrast agent microbubbles were combined with magnetic resonance imaging (MRI)-guided focused ultrasound (MRgFUS) as a means to achieve mild hyperthermia at reduced power levels. METHODS: MRgFUS hyperthermia (42°C for 20 min) was evaluated in rabbit thigh muscle or Vx2 tumors using infusions of microbubbles (Definity, 20 µL/kg) or saline (sham) administered over 5 min. The impact of treatments on drug uptake was assessed with liposomal doxorubicin (Caelyx, 2.5 mg/kg). Applied power levels before an...
Source: International Journal of Hyperthermia - October 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Development of custom RF coils for use in a small animal platform for magnetic resonance-guided focused ultrasound hyperthermia compatible with a clinical MRI scanner.
Authors: Abraham CB, Loree-Spacek J, Drainville RA, Pichardo S, Curiel L Abstract Three different magnetic resonance imaging (MRI) coils were developed and assessed for use with an experimental platform designed to generate hyperthermia in mice using magnetic resonance-guided focused ultrasound (MRgFUS). An ergonomic animal treatment bed was integrated with MRI coils. Three different coil designs optimized for small targets were tested, and performance in targeting and conducting accurate temperature imaging was evaluated. Two transmit/receive surface coils of different diameters (4 and 7 cm) and a transmit-...
Source: International Journal of Hyperthermia - October 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Innate/inflammatory bioregulation and clinical effectiveness of whole-body hyperthermia (balneotherapy) in elderly patients with osteoarthritis.
CONCLUSIONS: Balneotherapy with mud application was effective in the management of osteoarthritis symptoms. The anti-inflammatory effect mediated by cytokines contributed to the improvement in pain and joint function; and changes in the circulating percentage of regulatory T cells seem to be involved in the anti-inflammatory effects. Improvement in neutrophil function after mud therapy reflects an optimal bioregulatory effect on the inflammatory and innate responses. PMID: 30295126 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - October 9, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Tumor-specific CD8-positive T cell-mediated antitumor immunity is implicated in the antitumor effect of local hyperthermia.
This study aimed to elucidate the contribution of T cell-mediated antitumor immunity in the antitumor effect of local hyperthermia (LH). MATERIALS AND METHODS: C57BL/6J mice were injected with the mouse lymphoma cell line, E.G7-OVA, in the right femur on day 0. LH was induced by immersing the right femur in a water bath at 42 °C for 60 min on day 7, followed by administration of anti-CD8 monoclonal antibodies (mAb) or anti-CTLA-4 mAb (days 8, 11, and 14). The effect of LH on tumor growth (TG) was assessed by measuring the duration until tumor volume reached 1000 mm3 and survival time. Tumor-spe...
Source: International Journal of Hyperthermia - September 19, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison of ultrasound-guided high-intensity focused ultrasound ablation and surgery for abdominal wall endometriosis.
CONCLUSIONS: HIFU appears to be beneficial for the treatment of AWE, and may reduce adverse events. Compared with surgery, HIFU does not induce blood loss or tissue defects. PMID: 30208746 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 15, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Targetability of osteoid osteomas and bone metastases by MR-guided high intensity focused ultrasound (MRgHIFU).
CONCLUSION: MRgHIFU cannot be systematically performed non-invasively on bone tumors. Combination with minimally-invasive thermo-protective techniques may increase the number of eligible cases. PMID: 30208747 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 15, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Pepper and cinnamon improve cold induced cognitive impairment via increasing non-shivering thermogenesis; a study.
In conclusion, our results demonstrate that the cognitive impairment caused by exposure to cold can be effectively countered by agents with thermogenic potential. PMID: 30208750 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 15, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

"A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma" of Yoko Harima et  al. (2001): multiple biases and no advantage of hyperthermia.
"A randomized clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma" of Yoko Harima et al. (2001): multiple biases and no advantage of hyperthermia. Int J Hyperthermia. 2018 Dec;34(8):1400 Authors: Roussakow SV PMID: 30209978 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 15, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

"A randomised clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma" of Yoko Harima et  al. (2001): a response letter to the editor of comments from Dr. Roussakow.
"A randomised clinical trial of radiation therapy versus thermoradiotherapy in stage IIIB cervical carcinoma" of Yoko Harima et al. (2001): a response letter to the editor of comments from Dr. Roussakow. Int J Hyperthermia. 2018 Dec;34(8):1401 Authors: Harima Y PMID: 30209979 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 15, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The impact of gestational sac size on the effectiveness and safety of high intensity focused ultrasound combined with ultrasound-guided suction curettage treatment for caesarean scar pregnancy.
Authors: Zhang Y, Zhang C, He J, Bai J, Zhang L Abstract OBJECTIVE: To evaluate the correlation between the gestational sac size and the effect and safety of high intensity focused ultrasound (HIFU) combined with ultrasound-guided suction curettage for caesarean scar pregnancy (CSP). METHODS: Seventy-six patients with CSP were enrolled. Based on their gestational sac size, patients were divided into three groups: Group 1 (n = 16, 10-20 mm), Group 2 (n = 28, 21-30 mm) and Group 3 (n = 32,>30 mm). All of them were treated by HIFU combined with ultr...
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Long-term outcomes and prognostic analysis of percutaneous radiofrequency ablation in liver metastasis from breast cancer.
Authors: Bai XM, Yang W, Zhang ZY, Jiang AN, Wu W, Lee JC, Chen MH, Yan K Abstract OBJECTIVE: To evaluate the long-term efficacy and prognostic factors of ultrasound-guided percutaneous radiofrequency ablation (RFA) for breast cancer liver metastasis (BCLM). METHODS: Between 2000 and 2015, 69 patients who underwent ultrasound-guided percutaneous RFA for BCLM and had regular follow-up examinations were included. All patients had undergone resection of the primary breast cancer and had received chemotherapy, endocrine therapy or both after surgery. The sample included two males and 67 females with an average age ...
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Large hepatocellular carcinomas: treatment with transarterial chemoembolization alone or in combination with percutaneous cryoablation.
Authors: Cui W, Fan W, Huang K, Wang Y, Lu M, Yao W, Li J Abstract PURPOSE: To evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with cryoablation (TACE-cryoablation) in large (main tumor ≥5 cm in diameter) hepatocellular carcinomas (HCCs). METHODS: From January 2010 to December 2015, 56 lesions in 56 patients were treated with combination therapy via a single TACE session followed by one to three percutaneous cryoablation sessions twice a week (TACE-cryoablation group). A total of 54 lesions in 54 patients were treated with TACE alone for two to six sessions once a m...
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided laser ablation for local control of neck recurrences of medullary thyroid cancer. A feasibility study.
CONCLUSIONS: LA is a promising tool for the management of relapsing cervical metastases that are localized in non- critical areas and are characterized by low progression rate. Advantages of LA are the outpatient setting, the absence of general anesthesia, the tolerability and the safety of the procedure. Thus, LA may be considered as an alternative approach to surgery or active surveillance for the management of local recurrences of MTC in selected patients. PMID: 30204004 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Systematic quality assurance of the BSD2000-3D MR-compatible hyperthermia applicator performance using MR temperature imaging.
CONCLUSION: The Pyrexar BSD2000-3D MR-compatible applicator provides robust and reproducible heating. The upper boundary of the 95% confidence interval of the spatial steering accuracy is 0.9 cm, i.e. sufficient to fulfil the criterion of ≤0.2 °C temperature variation due to positioning errors as defined by Canters et al. PMID: 30204006 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound and cone beam CT fusion for liver ablation: technical note.
Authors: Monfardini L, Orsi F, Caserta R, Sallemi C, Della Vigna P, Bonomo G, Varano G, Solbiati L, Mauri G Abstract PURPOSE: To assess the feasibility of fusion imaging between intraprocedural ultrasound (US) and contrast-enhanced cone-beam CT (CBCT) for small (
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Estimation of the temperature field in laser-induced hyperthermia experiments with a phantom.
CONCLUSIONS: This article demonstrated that the Particle Filter method can be used to accurately predict the temperatures in regions where measurements are not available. The present technique has potential applications in hyperthermia treatments as an observer for active control strategies, as well as to plan personalized heating protocols. PMID: 30204008 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

High intensity focused ultrasound (HIFU) for the treatment of symptomatic breast fibroadenoma.
CONCLUSION: US-guided HIFU is an effective procedure and a minimally invasive alternative for the treatment of breast FA. PMID: 30204024 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Oliguric acute kidney injury after microwave ablation of large liver tumors: incidence and preventive measures.
This study evaluated the clinical features, mechanisms, risk factors and prevention strategies for oliguric AKI after MWA of large liver tumors. METHODS: From March 2011 to May 2015, 441 patients with liver tumors ≧5 cm received MWA in our hospital. The clinical features, prevention strategies, further mechanisms and possible risk factors for oliguric AKI after MWA were analyzed. RESULTS: One hundred four (23.6%) patients had AKI after MWA; 11 (10.6%) patients had oliguric AKI, and 93 (89.4%) patients had nonoliguric AKI. All patients with nonoliguric AKI recovered without any special treatments. The eleve...
Source: International Journal of Hyperthermia - September 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A propensity score matching study between ultrasound-guided percutaneous microwave ablation and conventional thyroidectomy for benign thyroid nodules treatment.
CONCLUSIONS: Our study demonstrated that US-guided PMWA is characterized by a definite therapeutic success rate, good cosmetic effect, slight injury and rapid recovery. US-guided PMWA is an effective technique for benign thyroid nodules treatment.. PMID: 30176761 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - September 6, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research