Percutaneous ablation of the tumor feeding artery for hypervascular hepatocellular carcinoma before tumor ablation.
This study was registered at the clinical trials registry website (No. NCT03143140). The mean tumor size was 3.2 ± 0.9 cm (2.0-5.0 cm). The mean follow-up was 23.7 ± 9.7 months (4-44 months). The technical success, local tumor progression and intrahepatic distant recurrence rates were compared. Survival analysis was performed using the Kaplan-Meier method and compared with the log-rank test. RESULTS: The local tumor progression rate was significantly lower for the PAA + RFA group than for the RFA group (8.5% vs 21.3%, p 
Source: International Journal of Hyperthermia - July 14, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Percutaneous thermal ablation of hepatocellular carcinomas located in the hepatic dome using artificial carbon dioxide pneumothorax: retrospective evaluation of safety and efficacy.
CONCLUSION: CT-guided PTA after artificially induced CO2 pneumothorax is a safe and efficient technique to treat HCC located in the hepatic dome. PMID: 29923441 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 28, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

International Journal of Hyperthermia Editors' Award Winners, 2017.
Authors: PMID: 29938570 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 28, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Reply to letter: Nephrotoxic synergism of cisplatin and mitomycin-C for hyperthermic intraperitoneal chemotherapy and cytoreductive surgery by Kapoor R, Robinson K and Badgwell B.
Authors: Tan GHC, Shannon NB, Chia C, Soo KC, Teo M PMID: 29938571 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 28, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Nephrotoxic synergism of cisplatin and mitomycin-C for hyperthermic intraperitoneal chemotherapy and cytoreductive surgery.
Authors: Kapoor R, Robinson KA, Badgwell B PMID: 29938572 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 28, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Invasive pulmonary aspergillosis secondary to microwave ablation: a multicenter retrospective study.
CONCLUSIONS: Lung MWA may be an additional host risk factor for IPA, particularly in elderly patients with underlying diseases and in patients who have recently undergone chemotherapy. Early and accurate diagnosis of IPA after MWA is critical for patient prognosis. Voriconazole should be given as the first-line treatment as early as possible. Bronchial artery embolization or intracavitary lavage may be required in some patients. PMID: 29874934 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 8, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Study of enhanced radiofrequency heating by pre-freezing tissue.
Authors: Zhang K, Zou J, He K, Xu L, Liu P, Li W, Zhang A, Xu LX Abstract In our previous animal model study, we found that radiofrequency (RF) ablation of pre-frozen tumor resulted in improved therapeutic effects. To understand the underlying mechanisms and optimize the treatment protocol, the RF heating pattern in pre-frozen tissue was studied in this paper. Both ex vivo and in vivo experiments were conducted to compare the temperature profiles of RF heating with or without pre-freezing. Results showed that the heating rate of in vivo tissues was significantly higher with pre-freezing. However, little difference ...
Source: International Journal of Hyperthermia - June 7, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Is there a role for minimally invasive thermal ablations in the treatment of autonomously functioning thyroid nodules?
Authors: Pacella CM, Mauri G PMID: 29793352 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Effects of internal electrode cooling on irreversible electroporation using a perfused organ model.
CONCLUSIONS: The internally-cooled bipolar applicator offers advantages that could improve clinical outcomes. Thermally mitigating internal perfusion technology reduced tissue temperatures and electric current while maintaining similar lesion sizes. PMID: 29806513 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Increasing radiofrequency ablation volumes with the use of internally cooled electrodes and injected hydrochloric acid in ex vivo bovine livers.
Authors: Jiang XY, Zhang TQ, Li G, Gu YK, Gao F, Yao W, Zhang YY, Huang JH Abstract PURPOSE: We used an impedance-controlled generator with an internally cooled electrode to perform radiofrequency ablation (RFA) in ex vivo bovine livers, with a single injection of either 38.5% sodium chloride (NaCl) or 10% hydrochloric acid (HCl), to determine the relative effects of these two solutions on tissue impedance, temperature and ablation volume. MATERIALS AND METHODS: We performed 10 ablations each with injections of NaCl (NaCl-RFA), HCl (HCl-RFA) or nothing (RFA-alone), with a power setting of 200 W for 15 mi...
Source: International Journal of Hyperthermia - June 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Local tumor progression after ultrasound-guided percutaneous microwave ablation of stage T1a renal cell carcinoma: risk factors analysis of 171 tumors.
CONCLUSIONS: US-guided percutaneous MWA for T1a RCC achieved a relatively low LTP incidence rate. Tumors adjacent to the renal pelvis or bowel increased the potential of LTP occurrence. PMID: 29807450 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - June 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Adverse effect analysis of high-intensity focused ultrasound in the treatment of benign uterine diseases.
CONCLUSIONS: Based on the results with low rate of major adverse effects from multiple centers, we concluded that HIFU is safe in treating patients with benign uterine diseases. With development of this technique and more experience on the part of the physicians, the rates of the major adverse effects will be further lowered. PMID: 29792359 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 27, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Design and simulation of novel laparoscopic renal denervation system: a feasibility study.
CONCLUSIONS: We developed a novel laparoscope-based electrosurgical RDN method for hypertension treatment. The feasibility of our system was confirmed through a simulation study as well as in vitro experiments. Our proposed method could be an effective treatment for resistant hypertension as well as central nervous system diseases. PMID: 29772927 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 22, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors.
Authors: Vaupel P, Piazena H, Müller W, Notter M Abstract Thermography-controlled, water-filtered infrared-A (wIRA) is a novel, effective and approved heating technique listed in the ESHO quality assurance guidelines for superficial hyperthermia clinical trials (2017). In order to assess the special features and the potential of wIRA-hyperthermia (wIRA-HT), detailed and updated information about its physical and photobiological background is presented. wIRA allows for (a) application of high irradiances without skin pain and acute grade 2-4 skin toxicities, (b) prolonged, therapeutically relevant exposure time...
Source: International Journal of Hyperthermia - May 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma - a feasibility study.
CONCLUSION: Hyperthermia with the HYPERcollar proved to be safe and feasible with good compliance and promising outcome. PMID: 29747544 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose.
CONCLUSION: This planning study indicates that the largest therapeutic gain for thermoradiotherapy in cervical cancer patients can be obtained when hyperthermia is delivered immediately before or after radiotherapy. PMID: 29749270 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided percutaneous laser ablation is safe and effective in the treatment of small renal tumors in patients at increased bleeding risk.
CONCLUSIONS: LA is safe and effective in the treatment of small RCC and might represent a valid option in patients with increased risk of bleeding. PMID: 29749271 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Fluorodeoxyglucose positron emission tomography for detection of tumor recurrence following radiofrequency ablation in retrospective cohort of stage I lung cancer.
CONCLUSION: A pattern of focally intense and increasing FDG PET uptake has high sensitivity and specificity for detecting recurrent lung cancer following RFA. Surveillance after RFA should include a contrast enhanced diagnostic CT at 1 month to diagnose procedural complications, PET at 6 months as a post-treatment metabolic baseline (with diagnostic CT if PET is abnormal) and alternating diagnostic CTs or PET every 6 months for 2 years. PMID: 29719997 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 5, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave ablation with chemoembolization for large hepatocellular carcinoma in patients with cirrhosis.
CONCLUSION: MWA-TACE is a safe, feasible and effective therapy for the treatment of 5.0- to 10.0-cm HCC lesions in patients with cirrhosis. PMID: 29720001 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - May 5, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Prognostic scores for colorectal cancer with peritoneal metastases treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.
CONCLUSION: The mCOREP has successfully been simplified while still improving its prognostic ability. The mCOREP and COMPASS scores have independent prognostic value. Patients with mCOREP 11 + may not benefit from treatment. PMID: 29695209 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 28, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Analysis of Clinical Data to Determine the Minimum Number of Sensors Required for Adequate Skin Temperature Monitoring of Superficial Hyperthermia Treatments.
CONCLUSIONS: Adequate coverage of the skin temperature distribution during superficial hyperthermia treatment requires the use of>50 stationary sensors per 400 cm2 applicator. Thermal mapping is a valid alternative. PMID: 29658357 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 18, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Radiofrequency ablation (RFA) induced systemic tumor growth can be reduced by suppression of resultant heat shock proteins.
Authors: Ahmed M, Kumar G, Gourevitch S, Levchenko T, Galun E, Torchilin V, Goldberg SN Abstract PURPOSE: To determine the role of hepatic RFA heating parameters and their activation of heat shock proteins (HSPs) in modulating distant tumor growth. METHODS: First, to study effects of RFA dose on distant tumor growth, rats with subcutaneous R3230 adenocarcinoma (10 ± 1 mm) were assigned to 3 different hepatic RF doses (60°C × 10 min, 70°C × 5 min, or 90°C × 2 min) that induced identical sized ablation or sham (n = 6/arm). Post-RFA tum...
Source: International Journal of Hyperthermia - April 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Ultrasound-guided percutaneous microwave ablation versus surgery for papillary thyroid microcarcinoma.
Authors: Li J, Liu Y, Liu J, Qian L Abstract BACKGROUND: Papillary thyroid microcarcinoma (PTMC) has high incidence and low disease-specific mortality. However, active surveillance is not accepted by most patients owing to high physical or psychological pressures. The emergence of ablation technologies is supplanting traditional surgery. Our goal was to compare the clinical outcomes of microwave ablation (MWA) and surgery for T1aN0M0 PTMC. METHODS: A total of 92 consecutive patients with T1aN0M0 PTMC were studied retrospectively. Forty-six patients had been treated with MWA, and the other 46 had undergone surge...
Source: International Journal of Hyperthermia - April 12, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Feasibility of bipolar radiofrequency ablation in patients with parathyroid adenoma: A first evaluation.
CONCLUSION: For the first time, it was possible to depict the successful therapy of parathyroid adenoma by means of bRFA. This work thus proves bRFA to be an effective, safe, applicable and, concerning sensation of pain, very well tolerable thermoablative technique in the treatment of parathyroid adenoma. PMID: 29607692 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 4, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Microwave Ablation Compared to Thyroidectomy to Treat Benign Thyroid Nodules.
CONCLUSIONS: MWA can significantly reduce nodule volume and nodule-related symptoms with more rapid recovery, more pleasing esthetic outcomes, less physiologic disruption and less expense compared to the surgery. PMID: 29577796 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 28, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

A Multimodality Imaging-compatible Insertion Robot with A Respiratory Motion Calibration Module Designed for Ablation of Liver Tumors: A Preclinical Study.
CONCLUSION: The multimodality imaging-compatible insertion robot with a respiratory motion calibration module designed for ablation of liver tumors could increase the insertion accuracy and ablation efficacy, and minimize the influence of the physicians' experience. The ablation procedure could be more comfortable with less stress with the application of the robot. PMID: 29566561 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 25, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Transurethral High Intensity Ultrasound for Treatment of Stress Urinary Incontinence (SUI): Simulation Studies with Patient Specific Models.
The objective of this in silico study is to explore transurethral high intensity ultrasound for delivery of precise thermal therapy to the endopelvic tissues adjacent to the mid-urethra, to induce thermal remodelling as a potential minimally invasive treatment alternative. METHODS: 3D acoustic (Rayleigh-Sommerfeld) and biothermal (Pennes Bioheat) models of the ultrasound applicator and surrounding tissues were devised. Parametric studies over transducer configuration (frequency, radius-of-curvature (ROC)) and treatment settings (power, duration) were performed, and select cases on patient specific models were used for ...
Source: International Journal of Hyperthermia - March 25, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Factors influencing thermal injury to skin and abdominal wall structures in HIFU ablation of uterine fibroids.
Authors: Yin N, Hu L, Xiao ZB, Liu C, Chen WZ, Roberts N, Chen JY, Wang ZB Abstract OBJECTIVE: To investigate the factors which may cause thermal injury of abdominal wall structures in ultrasound-guided high-intensity focussed ultrasound (USgHIFU) ablation of uterine fibroids. METHOD: A total of 892 patients with uterine fibroids diagnosed on contrast-enhanced magnetic resonance imaging (MRI) scans received HIFU ablation and follow-up MRI scanning. After therapy, thermal injury to the skin was assessed via measurement of skin redness, blisters, subcutaneous nodules and to the abdominal wall structures via measu...
Source: International Journal of Hyperthermia - March 8, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Local recurrence rate in patients with colorectal cancer liver metastasis after wedge resection or percutaneous radiofrequency ablation.
Authors: Vietti Violi N, Duran R, Demartines N, Sempoux C, Guiu B, Bize PE, Sala N, Halkic N, Knebel JF, Denys A Abstract PURPOSE: To compare local recurrence (LR) rate in patients with colorectal cancer liver metastasis (CRCLM) after surgical wedge resection (WR) or radiofrequency ablation (RFA) and to investigate predictive factors of LR. MATERIALS AND METHODS: This single-centre, retrospective, institutional review board-approved study including 43 consecutive patients with 121 metastases treated by WR and 60 patients with 110 metastases treated by RFA between 2007 and 2014 with 23 and 18.5 months of ...
Source: International Journal of Hyperthermia - March 8, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Locoregional hyperthermia of deep-seated tumors applied with capacitive and radiative systems: a simulation study.
CONCLUSION: Generally, radiative locoregional heating yields more favorable simulated temperature distributions for deep-seated pelvic tumors, compared with capacitive heating. Therapeutic temperatures are predicted for capacitive heating in patients with (almost) no fat. PMID: 29509043 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 8, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Inactivation kinetics of food-borne pathogens subjected to thermal treatments: a review.
This study presents a comprehensive review of recent progresses in inactivation kinetics of food-borne pathogens. It covers theoretical bases and experimental methods for developing thermal inactivation kinetics of food-borne pathogens and making comparisons and applications of the common thermal death kinetic models. Finally, it proposes possible recommendations on the future research directions of establishing inactivation kinetic models for food-borne pathogens in thermal processing. PMID: 29498308 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Temperature-sensitive liposomal ciprofloxacin for the treatment of biofilm on infected metal implants using alternating magnetic fields.
In this study, we treated a metal prosthesis infection model using a combination of ciprofloxacin-loaded temperature-sensitive liposomes (TSL) and alternating magnetic fields (AMF). AMF heating is used to disrupt the biofilm and release the ciprofloxacin-loaded TSL. The three main objectives of this study were to (1) investigate low- and high-temperature-sensitive liposomes (LTSLs and HTSLs) containing the antimicrobial agent ciprofloxacin for temperature-mediated antibiotic release, (2) characterise in vitro ciprofloxacin release and stability and (3) study the efficacy of combining liposomal ciprofloxacin with AMF agains...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

An overview of the role of sympathetic regulation of immune responses in infectious disease and autoimmunity.
Authors: Bucsek MJ, Giridharan T, MacDonald CR, Hylander BL, Repasky EA Abstract Stress in patients and pre-clinical research animals plays a critical role in disease progression Activation of the sympathetic nervous system (SNS) by stress results in secretion of the catecholamines epinephrine (Epi) and norepinephrine (NE) from the adrenal gland and sympathetic nerve endings. Adrenergic receptors for catecholamines are present on immune cells and their activity is affected by stress and the accompanying changes in levels of these neurotransmitters. In this short review, we discuss how this adrenergic stress impacts...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Heat transfer from nanoparticles for targeted destruction of infectious organisms.
Authors: Cortie MB, Cortie DL, Timchenko V Abstract Whereas the application of optically or magnetically heated nanoparticles to destroy tumours is now well established, the extension of this concept to target pathogens has barely begun. Here we examine the challenge of targeting pathogens by this means and, in particular, explore the issues of power density and heat transfer. Depending on the rate of heating, either hyperthermia or thermoablation may occur. This division of the field is fundamental and implies very different sources of excitation and heat transfer for the two modes, and different strategies for th...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Thermal shock susceptibility and regrowth of Pseudomonas aeruginosa biofilms.
Authors: Ricker EB, Aljaafari HAS, Bader TM, Hundley BS, Nuxoll E Abstract Biofilms on implanted medical devices cause thousands of patients each year to undergo multiple surgeries to remove and replace the implant, driving billions of dollars in increased health care costs due to the lack of viable treatment options for in situ biofilm eradication. Remotely activated localised heating is under investigation to mitigate these biofilms; however, little is known about the temperatures required to kill the biofilms. To better understand the required parameters this study investigated the thermal susceptibility of biof...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Introduction to the special issue on thermal therapy and infectious diseases.
Authors: Chopra R, Levi-Polyachenko N, Smeltzer MS PMID: 29498313 [PubMed - in process] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Progress on utilizing hyperthermia for mitigating bacterial infections.
Authors: Ibelli T, Templeton S, Levi-Polyachenko N Abstract Recovery from systemic or local bacterial infections can be lengthy and costly, with the clinical challenges being further complicated when bacteria acquire resistance to current antibiotics. Hyperthermia offers new mechanisms for removing bacteria via ablation, or sensitising them to chemical agents. The first part of this review provides a background on the bacterial biofilms, their response to hyperthermia, and acquired resistance to antibiotics, followed by the clinical challenges they present in managing infections associated with soft tissues and bio...
Source: International Journal of Hyperthermia - March 3, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Comparison between single- and dual-porosity models for fluid transport in predicting lesion volume following saline-infused radiofrequency ablation.
Authors: Ooi EH, J Y Chia N, Ooi ET, Foo JJ, Liao IY, R Nair S, Mohd Ali AF Abstract A recent study by Ooi and Ooi (EH Ooi, ET Ooi, Mass transport in biological tissues: Comparisons between single- and dual-porosity models in the context of saline-infused radiofrequency ablation, Applied Mathematical Modelling, 2017, 41, 271-284) has shown that single-porosity (SP) models for describing fluid transport in biological tissues significantly underestimate the fluid penetration depth when compared to dual-porosity (DP) models. This has raised some concerns on whether the SP model, when coupled with models of radiofreque...
Source: International Journal of Hyperthermia - March 2, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

High Power Microwave Ablation of Normal Swine Lung: Impact of Duration of Energy Delivery on Adverse Event and Heat Sink Effects.
Authors: Kodama H, Ueshima E, Gao S, Monette S, Paluch LR, Howk K, Erinjeri JP, Solomon SB, Srimathveeravalli G Abstract PURPOSE: To assess the impact of duration of energy delivery on adverse events (AEs) and heat sink effects during high power microwave ablation (MWA) of normal swine lung. MATERIALS AND METHODS: High power (100 Watts) MWA was performed with short (2 minutes, 18 ablations) or long (10 minutes, 9 ablations) duration of energy delivery in unilateral lung of swine (n = 10). CT imaging was done prior to sacrifice at 2 or 28 days post-treatment, with additional imaging a...
Source: International Journal of Hyperthermia - March 2, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Laser immunotherapy for cutaneous squamous cell carcinoma with optimal thermal effects to enhance tumor immunogenicity.
Authors: Luo M, Shi L, Zhang F, Zhou F, Zhang L, Wang B, Wang P, Zhang Y, Zhang H, Yang D, Zhang G, Chen WR, Wang X Abstract BACKGROUND: Laser immunotherapy is a new anti-cancer therapy combining photothermal therapy and immunostimulation. It can eliminate the tumors by damaging tumor cells directly and promoting the release of damage-associated molecular patterns (DAMPs) to enhance tumor immunogenicity. The aim of this study was to investigate the thermal effects of laser immunotherapy and to evaluate the effectiveness and safety of laser immunotherapy for cutaneous squamous cell carcinoma (cSCC). METHODS: The...
Source: International Journal of Hyperthermia - March 1, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Technical analysis of US imaging for precise microwave ablation for benign breast tumours.
Authors: Li C, Li C, Ge H, Liang M, Ma G, Ling L, Pan H, Gong H, Xie H, Ding Q, Zhou W, Wang S Abstract PURPOSE: To determine thecharacteristicsof ultrasound (US) imaging of completelyablated cases and theeffects of duration and clinical experience on accurate microwave ablation (MWA) for the treatment of benign breast tumours. METHODS: With written informed consent and approval of the institutional ethics committee, patients with symptomatic or palpable benign breast tumours (longest diameter, 7-32mm), to whom MWA (2450MHz) was performed, were enrolled in this prospective nonrandomized study.US and contrast-en...
Source: International Journal of Hyperthermia - February 21, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Proceedings of the First Italian Conference on Thyroid Minimally Invasive Treatments and foundation of the Italian Research Group for Thyroid Minimally Invasive Procedures.
Authors: Mauri G, Pacella CM, Papini E, Sconfienza LM, Solbiati L PMID: 29455559 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 20, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Hepatocellular carcinoma abutting large vessels: Comparison of four percutaneous ablation systems.
CONCLUSION: Multi-applicator RFA provides better local tumor control in HCC abutting large vessels than single-applicator techniques (monopolar RFA or MWA). PMID: 29457510 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 20, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Safety and effect on ablation size of Hydrochloric Acid-perfused Radiofrequency Ablation in animal livers.
Authors: Zhang TQ, Huang SM, Gu YK, Gao F, Huang ZM, Jiang XY, Liu DX, Huang JH Abstract PURPOSE: Our objective was to determine the safety and ablation size of hydrochloric acid-perfused radiofrequency ablation (HCl-RFA) in liver tissue, prospectively using in vivo rabbit and ex vivo porcine liver models. MATERIALS AND METHODS: The livers in 30 rabbits were treated in vivo with perfusions of normal saline (controls) and HCl concentrations of 5%, 10%, 15%, and 20%, during RFA at 103°C and 30 W for 3 minutes. For each experimental setting, 6 ablations were created. Safety was assessed by comparing bas...
Source: International Journal of Hyperthermia - February 20, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Summary of numerical analyses for therapeutic uses of laser-activated gold nanoparticles.
Authors: Mesicek J, Kuca K Abstract The optimal light dose, heat generation, consequent heat spread, and an accurate thermal damage model, are key components of effective laser therapies. Recent advances in nanotechnology offer numerous possibilities on how to increase the efficacy of hyperthermia for tumour treatments. Gold nanoparticles are a promising candidate towards the achievement of this goal owing to their properties for efficiently converting light to heat. In this review, we summarise the numerical tools that are available for theoretical studies of gold-nanoparticle-mediated photo-thermal therapy. The p...
Source: International Journal of Hyperthermia - February 17, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Effect of pretreatment with gonadotropin-releasing hormone analog GnRH- α on high-intensity focused ultrasound ablation for diffuse adenomyosis: a preliminary study.
Effect of pretreatment with gonadotropin-releasing hormone analog GnRH-α on high-intensity focused ultrasound ablation for diffuse adenomyosis: a preliminary study. Int J Hyperthermia. 2018 Feb 15;:1-19 Authors: Zhang XY, Guo YS, Chen JM, Wang JJ, Ye H, Zang CY, Duan H Abstract OBJECTIVES: To evaluate the efficacy and safety of GnRH-α pretreatment with HIFU ablation for diffuse adenomyosis. METHODS: From January 2014 to December 2016, 61 patients were divided into two groups. Twenty-three patients with larger uteri received pretreatment with GnRH-αand were then subjected to HIFU, ...
Source: International Journal of Hyperthermia - February 17, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Are infectious diseases and microbiology new fields for thermal therapy research?
Authors: Gazel D, Yılmaz M Abstract Antimicrobial chemotherapy and surgery are classical methods for treating infectious diseases. However, there is a need for alternative methods to cure infections caused by antibiotic-resistant pathogens, recurrent or chronic infections, and unreachable local infections in which the use of drugs or surgery is anatomically and physically restricted. Several microorganisms are known to be sensitive to mild hyperthermia, and this sensitivity is one of the potential benefits proposed for the host during an episode of fever. Additionally, some immunological or biophysical changes occ...
Source: International Journal of Hyperthermia - February 17, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Mechanical Fractionation of Tissues using Microsecond-Long HIFU Pulses on a Clinical MR-HIFU System.
CONCLUSION: Clinical MR-HIFU system was utilized to generate distinct types of lesions and to produce targeted thermomechanical bioeffects in ex vivo tissues. The results guide HIFU research on thermomechanical tissue bioeffects, inform future studies, and advice sonication parameter selection for direct tumor ablation or immunomodulation using a clinical MR-HIFU system. PMID: 29429375 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 14, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Outcomes of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy for peritoneal mesothelioma and predictors of survival.
CONCLUSION: With adequate patient selection (guided by histological classification and Ki-67 proliferation index) and complete cytoreduction with HIPEC, satisfactory outcomes can be achieved in selected patients with peritoneal mesothelioma. PMID: 29431036 [PubMed - as supplied by publisher] (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - February 14, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research

Intra-articular application of pulsed radiofrequency combined with viscosupplementation for improvement of knee osteoarthritis symptoms: a single centre prospective study.
Authors: Filippiadis D, Velonakis G, Mazioti A, Konstantos C, Brountzos E, Kelekis N, Kelekis A Abstract OBJECTIVES: To prospectively evaluate the effectiveness of intra-articular application of pulsed radiofrequency (PRF) combined with viscosupplementation in patients with knee osteoarthritis suffering from chronic pain refractory to conservative therapies. METHODS: During a 30-month period, PRF combined with viscosupplementation was performed on 53 cases of knee osteoarthritis (45 patients, 8/45 with bilateral knee osteoarthritis). Pre-operational imaging included standard knee X-rays on anterior-posterior an...
Source: International Journal of Hyperthermia - February 10, 2018 Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research