Intravoxel incoherent motion (IVIM)-derived perfusion fraction mapping for the visual evaluation of MR-guided high intensity focused ultrasound (MR-HIFU) ablation of uterine fibroids
CONCLUSION: The MR-HIFU treatment effect in uterine fibroids can be visualized using IVIM perfusion fraction mapping, in moderate concordance with contrast enhanced MRI. IVIM perfusion fraction mapping has therefore the potential to serve as a contrast agent-free imaging method to visualize the MR-HIFU treatment progression in uterine fibroids.PMID:38616245 | DOI:10.1080/02656736.2024.2321980 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 14, 2024 Category: Internal Medicine Authors: Derk J Slotman Lambertus W Bartels Ingrid M Nijholt Martijn Froeling Judith A F Huirne Chrit T W Moonen Martijn F Boomsma Source Type: research

Microwave hyperthermia enhances radiosensitization by decreasing DNA repair efficiency and inducing oxidative stress in PC3 prostatic adenocarcinoma cells
CONCLUSION: MW-HT + RT treatment significantly inhibited DNA damage repair by downregulating DNA-PKcs, ATM, ATR, and P53/P21 signaling pathways, leading to increased ROS levels, aggravate DNA damage, apoptosis, and necrosis in PC3 cells, a well-established model of CRPC.PMID:38583875 | DOI:10.1080/02656736.2024.2335201 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 7, 2024 Category: Internal Medicine Authors: Yajun Wu Pengyuan Liu Wendy Chen Shiting Bai Sisi Chen Jianglin Chen Xiaogang Xu Jindan Xia Yufei Wu Jianjun Lai Chuan Sun Zhenghong Lao Xiaoqing Wan Zhibing Wu Source Type: research

Deregulated JNK signaling enhances apoptosis during hyperthermia
CONCLUSION: JNK was activated in a temperature-dependent manner despite reduced or transient phosphorylation of the upstream MAP3K and MAP2K. Hyperthermia-induced degradation of DUSP16 may induce activation of the ASK1-SEK1-JNK pathway and subsequent apoptosis.PMID:38565204 | DOI:10.1080/02656736.2024.2335199 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - April 2, 2024 Category: Internal Medicine Authors: Atsushi Enomoto Takemichi Fukasawa Hiroshi Terunuma Keiichi Nakagawa Ayumi Yoshizaki Shinichi Sato Noriko Hosoya Kiyoshi Miyagawa Source Type: research

Radiofrequency ablation of hepatocellular carcinoma guided by real-time physics-based ablation simulation: a prospective study
CONCLUSION: This prospective study found computer-assisted guidance that simulated each ablation was both safe and efficacious. The low rate of LTP was similar to studies that employed stereotactic guidance and ablation confirmation, without requiring a second contrast enhanced study.PMID:38503326 | DOI:10.1080/02656736.2024.2331704 (Source: International Journal of Hyperthermia)
Source: International Journal of Hyperthermia - March 19, 2024 Category: Internal Medicine Authors: Eric K Hoffer Mary C Drinane Vikrant Bhatnagar Riya Mehta David P Munger Andrea Borsic Source Type: research