Caudo-dorsal approach combined with the occlusion of right hepatic vein and Pringle maneuver in laparoscopic anatomical resection of segment 7
ConclusionThe caudo-dorsal approach combined with the occlusion of RHV and the Pringle maneuver may be a feasible and expected technique for safe exposure of RHV in LARS7. Further validation of the feasibility and efficacy of this technique is needed. (Source: Surgical Endoscopy)
Source: Surgical Endoscopy - May 16, 2024 Category: Surgery Source Type: research
Cost-of-Illness of Skin Cancer: A Systematic Review
ConclusionsA homogeneous skin cancer cost-of-illness study design would be beneficial to enhance between-studies comparability, identification of cost drivers, and support evidence-based decision-making for skin cancer. (Source: PharmacoEconomics)
Source: PharmacoEconomics - May 16, 2024 Category: Health Management Source Type: research
Lipid Identification of Biomarkers in Esophageal Squamous Cell Carcinoma by Lipidomic Analysis
. (Source: Nutrition and Cancer)
Source: Nutrition and Cancer - May 16, 2024 Category: Cancer & Oncology Authors: Tingwei SiDaoqin LiuLei LiZichen XuLuqing JiangYing ZhaiQiwen Wua Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, Chinab Department of Kidney Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, Chin Source Type: research
Exploration of lymph node recurrence patterns and delineation guidelines of radiation field in middle thoracic oesophageal carcinomas after radical surgery: a real-world study
Oesophageal squamous cell carcinoma is one of the most commonly diagnosed carcinomas in China, and postoperative radiotherapy plays an important role in improving the prognosis of patients. Carcinomas in diffe... (Source: BMC Cancer)
Source: BMC Cancer - May 16, 2024 Category: Cancer & Oncology Authors: Rongxu Du, Songqing Fan, Dan Yang, Xiaobin Wang, Xia Hou, Cheng Zeng, Dan Guo, Rongrong Tian, Leilei Jiang, Xin Dong, Rong Yu, Huiming Yu, Shuchai Zhu, Jie Li and Anhui Shi Tags: Research Source Type: research
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
AbstractLiver cirrhosis due to nonalcoholic steatohepatitis (NASH) is a life-threatening condition with increasing incidence world-wide. Although its symptoms are unspecific, it can lead to decompensation events such as ascites, hepatic encephalopathy, variceal hemorrhage, and hepatocellular carcinoma (HCC). In addition, an increased risk for cardiovascular events has been demonstrated in patients with NASH. Pharmacological treatments for NASH cirrhosis are not yet available, one of the reasons being the lack in surrogate endpoints available in clinical trials of NASH cirrhosis. The feasibility of non-invasive prognostic b...
Source: Journal of Molecular Medicine - May 16, 2024 Category: Molecular Biology Source Type: research
Characterization of extrachromosomal circular DNAs in plasma of patients with clear cell renal cell carcinoma
ConclusionThis work demonstrates the characterization of plasma eccDNAs in ccRCC and suggests that the up-regulated plasma eccDNAs could be considered as a promising non-invasive biomarker in ccRCC. (Source: World Journal of Urology)
Source: World Journal of Urology - May 16, 2024 Category: Urology & Nephrology Source Type: research
Molecules, Vol. 29, Pages 2346: Synthesis of Rhodamine-Conjugated Lupane Type Triterpenes of Enhanced Cytotoxicity
© Csuk
Various conjugates with rhodamines were prepared by starting with betulinic acid (BA) and platanic acid (PA). The molecules homopiperazine and piperazine, which were identified in earlier research, served as linkers between the rhodamine and the triterpene. The pentacyclic triterpene’s ring A was modified with two acetyloxy groups in order to possibly boost its cytotoxic activity. The SRB assays’ cytotoxicity data showed that conjugates 13–22, derived from betulinic acid, had a significantly higher cytotoxicity. Of these hybrids, derivatives 19 (containing rhodamine B) a...
Source: Molecules - May 16, 2024 Category: Chemistry Authors: Toni C. Denner Niels V. Heise Sophie Hoenke Ren é Csuk Tags: Article Source Type: research
Assessment of thermal damage for plasmonic photothermal therapy of subsurface tumors
AbstractPlasmonic photothermal therapy (PPTT) involves the use of nanoparticles and near-infrared radiation to attain a temperature above 50  °C within the tumor for its thermal damage. PPTT is largely explored for superficial tumors, and its potential to treat deeper subsurface tumors is dealt feebly, requiring the assessment of thermal damage for such tumors. In this paper, the extent of thermal damage is numerically analyzed for PPT T of invasive ductal carcinoma (IDC) situated at 3–9 mm depths. The developed numerical model is validated with suitable tissue-tumor mimicking phantoms. Tumor (IDC) embedded with gold ...
Source: Australasian Physical and Engineering Sciences in Medicine - May 16, 2024 Category: Biomedical Engineering Source Type: research
SPG21, a potential oncogene targeted by miR-128-3p, amplifies HBx-induced carcinogenesis and chemoresistance via activation of TRPM7-mediated JNK pathway in hepatocellular carcinoma
ConclusionThe study suggested that SPG21, targeted by miR-128-3p, might be involved in enhancing HBx-induced carcinogenesis and doxorubicin resistance in HCC via the TRPM7/Ca2+/JNK signaling pathway. This insight suggested that SPG21 could be recognized as a potential oncogene, offering a novel perspective on its role as a prognostic factor and a therapeutic target in the context of HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - May 16, 2024 Category: Cancer & Oncology Source Type: research
Cancers, Vol. 16, Pages 1904: Financial Toxicity in Japanese Patients with Metastatic Renal Cell Carcinoma: A Cross-Sectional Study
This study enrolled Japanese patients who underwent, or were undergoing, systemic therapy for mRCC. The outcomes evaluated were the distribution of COST scores, the correlation between COST and quality of life (QOL) assessed by the Functional Assessment of Cancer Therapy-General (FACT-G) scale, and demographic factors associated with financial toxicity. The median (range) COST score was 19.0 (3.0–36.0). The Pearson correlation coefficient for COST and FACT-G total scores was 0.40. Univariate analysis revealed that not having private health insurance and lower household income per year were significantly assoc...
Source: Cancers - May 16, 2024 Category: Cancer & Oncology Authors: Go Kimura Yasuhisa Fujii Kazunori Honda Takahiro Osawa Yosuke Uchitomi Miki Kondo Ariko Otani Tetsuya Wako Daisuke Kawai Yoshihide Mitsuda Naotaka Sakashita Nobuo Shinohara Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1903: Navigating the Maze: Exploring Non-Oncological Complexities in Non-Small-Cell Lung Cancer
eorgescu
Costache
Pulmonary oncological pathologies are an important public health problem and the association with other pulmonary lesions may pose difficulties in diagnosis and staging or require different treatment options. To address this complexity, we conducted a retrospective observational study at the Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania. Our study focused on patients admitted in 2019 with non-small-cell lung carcinoma and associated pulmonary lesions identified through surgical resection specimens. Among the 314 included patients, multiple pulmonary nodules were observed on macro...
Source: Cancers - May 16, 2024 Category: Cancer & Oncology Authors: Marghescu Vl ăsceanu Preda Țigău Dumitrache-Rujinski Leonte M ăgheran Tudor B ădărău Georgescu Costache Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1905: Role of 18F-FDG PET/CT in Head and Neck Squamous Cell Carcinoma: Current Evidence and Innovative Applications
This article provides an overview of the use of 18F-FDG PET/CT in various clinical scenarios of head–neck squamous cell carcinoma, ranging from initial staging to treatment-response assessment, and post-therapy follow-up, with a focus on the current evidence, debated issues, and innovative applications. Methodological aspects and the most frequent pitfalls in head–neck imaging interpretation are described. In the initial work-up, 18F-FDG PET/CT is recommended in patients with metastatic cervical lymphadenectomy and occult primary tumor; moreover, it is a well-established imaging tool for detecti...
Source: Cancers - May 16, 2024 Category: Cancer & Oncology Authors: Carmelo Caldarella Marina De Risi Mariangela Massaccesi Francesco Miccich è Francesco Bussu Jacopo Galli Vittoria Rufini Lucia Leccisotti Tags: Review Source Type: research
Accuracy of robotic radiosurgery in renal cell carcinoma
Stereotactic body radiotherapy (SBRT) using robotic radiosurgery is an emerging treatment option for patients with renal cell carcinoma [1 –4]. Single-fraction SBRT is clinically proven to be highly effective, with a local tumor control rate of 95 % at five years [3,5]. High doses in single-fraction treatments require high targeting accuracy to avoid toxicity to adjacent normal tissues. Tumors in the abdomen move with the respirator y cycle, leading to treatment uncertainties. Methods such as deep-inspiration breath-hold and compression aim to minimize organ motion during beam delivery. (Source: Physica Medica: European...
Source: Physica Medica: European Journal of Medical Physics - May 16, 2024 Category: General Medicine Authors: Theresa Hofmann, Nadja Kohlhase, Dochka Eftimova, Michael Martin Eder, Michael Staehler, Maximilian I. Ruge, Alexander Muacevic, Christoph F ürweger Tags: Original paper Source Type: research
Prediction of TNFRSF9 expression and molecular pathological features in thyroid cancer using machine learning to construct Pathomics models
ConclusionsThe GBM Pathomics model constructed based on the pathohistological features of H&E-stained sections well predicted the expression level ofTNFRSF9 molecules in THCA. (Source: Endocrine)
Source: Endocrine - May 16, 2024 Category: Endocrinology Source Type: research
DNMT1-targeting remodeling global DNA hypomethylation for enhanced tumor suppression and circumvented toxicity in oral squamous cell carcinoma
The faithful maintenance of DNA methylation homeostasis indispensably requires DNA methyltransferase 1 (DNMT1) in cancer progression. We previously identified DNMT1 as a potential candidate target for oral squ... (Source: Molecular Cancer)
Source: Molecular Cancer - May 16, 2024 Category: Cancer & Oncology Authors: Yangfan Liu, Yu Sun, Jin Yang, Deyang Wu, Shuang Yu, Junjiang Liu, Tao Hu, Jingjing Luo and Hongmei Zhou Tags: Research Source Type: research
