FKBP5 expression in human adipose tissue: potential role in glucose and lipid metabolism, adipogenesis and type 2 diabetes
AbstractPurposeHere, we explore the involvement of FKBP51 in glucocorticoid-induced insulin resistance (IR) in human subcutaneous adipose tissue (SAT), including its potential role in type 2 diabetes (T2D). Moreover, we assess the metabolic effects of reducing the activity of FKBP51 using the specific inhibitor SAFit1.MethodsHuman SAT was obtained by needle biopsies of the lower abdominal region.FKBP5 gene expression was assessed in fresh SAT explants from a cohort of 20 T2D subjects group-wise matched by gender, age and BMI to 20 non-diabetic subjects. In addition, human SAT was obtained from non-diabetic volunteers (20F/...
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Primary hyperparathyroidism: findings from the retrospective evaluation of cases over a 6-year period from a regional UK centre
We report a retrospective study of cases with PHPT managed at a regional centre in the United Kingdom.MethodsClinical data of cases with calcium ≥2.6 mmol/L and parathyroid hormone (PTH) ≥9.0 pmol/L was procured from biochemistry database from January 2011 to December 2016. Laboratory parameters, imaging studies for renal stones, osteoporosis and localisation of parathyroid adenomas, type of treatment received (PTX or nonsurgical), c omplications of treatment, other medical co-morbidities and mortality during follow-up was recorded in each case to examine the outcomes of care of patients with PHPT.Resul...
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Inhibition of endoplasmic reticulum stress by intermedin1-53 attenuates angiotensin II –induced abdominal aortic aneurysm in ApoE KO Mice
In conclusion, IMD may protect against AAA formation by inhibiting ERS via activating AMPK phosphorylation. (Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Ghrelin knockout mice display defective skeletal muscle regeneration and impaired satellite cell self-renewal
ConclusionsAlthough we cannot discern the specificGhrl-derived peptide responsible for such activities, these data indicate thatGhrl contributes to a proper muscle regeneration. (Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Great veins invasion in follicular thyroid cancer: single-centre study assessing prevalence and clinical outcome
ConclusionsGreat veins invasion may not be uncommon in FTC and preoperative detection and characterisation of such condition may optimise surgical approach and improve survival. (Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Use of 99m Tc-sestamibi SPECT/CT when conventional imaging studies are negative for localizing suspected recurrence in differentiated thyroid cancer: a method and a lesson for clinical management
Conclusions99mTc-sestamibi may have a role in thyroid cancer localization when physical exam, neck ultrasound, radioiodine scan, chest/abdomen CT, and18F-FDG PET/CT does not identify the source of elevated Tg levels in DTC. (Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Correction to: Multiple endocrine neoplasia type 1: analysis of germline MEN1 mutations in the Italian multicenter MEN1 patient database
The original version of this article unfortunately contained a mistake in Table 2. The table 2 was truncated in the original publication. The full table 2 is given below. (Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Long-term follow-up of female prolactinoma patients at child-bearing age after transsphenoidal surgery
ConclusionLong-term follow-up showed a high remission rate in female prolactinoma patients, especially in microadenoma patients, after surgery. Transsphenoidal surgery performed by experienced neurosurgeons may offer a valuable approach to treat female microprolactinoma patients of child-bearing age with modern indications for surgery. (Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Evaluation of melatonin and AFMK levels in women with breast cancer
AbstractPurposeChanges in the circadian rhythm may contribute to the development of cancer and are correlated with the high risk of breast cancer (BC) in night workers. Melatonin is a hormone synthesized by the pineal gland at night in the absence of light. Levels of melatonin and the metabolite of oxidative metabolism AFMK (acetyl-N-formyl-5-methoxykynurenamine), are suggested as potential biomarkers of BC risk. The aims of this study were to evaluate levels of melatonin and AFMK in women recently diagnosed with BC, women under adjuvant chemotherapy, and night-shift nurses, and compare them with healthy women to evaluate ...
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Acute pancreatitis as the first manifestation in a young boy with primary hyperparathyroidism
(Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Sildenafil normalizes MALAT1 level in diabetic cardiomyopathy
(Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Risk factors for central neck lymph node metastases in follicular variant vs. classic papillary thyroid carcinoma
AbstractPurposeHistological variants of papillary thyroid carcinoma (PTC) have been advocated as possible risk factors for central neck nodal metastases (CNM). A lower incidence of CNM in follicular variant of papillary thyroid carcinoma (fvPTC) when compared with classic PTC (cPTC) has been observed. We aimed to compare risk factors for CNM in patients with fvPTC and cPTC.MethodsThe medical records of 1737 patients with a diagnosis of cPTC or fvPTC were reviewed. Demographic, clinical and pathological findings were prospectively registered. Risk factors for CNM were evaluated by univariate and multivariate analysis in cPT...
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Low trabecular bone score in postmenopausal women with differentiated thyroid carcinoma after long-term TSH suppressive therapy
AbstractThe effect of thyroid suppression therapy (TST) on trabecular bone scores (TBS) and bone mineral density (BMD) in thyroidectomized women with differentiated thyroid carcinoma (DTC) on long-term follow-up is presently not conclusive. Patients and Methods. We carried out a study in 61 premenopausal and 84 postmenopausal Caucasian women with DTC. Serum biochemistry, bone markers, TBS, BMD, and bone fractures were evaluated 1 –3 months post surgery and after a median follow-up of 10 years. Results. In the final study, patients belonged to Group I Premenopausal (n = 14) who remained in this status; G...
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Putative endothelial progenitor cells predict long-term mortality in type-2 diabetes
(Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Clinical outcomes of childhood craniopharyngioma: can we do better?
(Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Statins as potential agents for the prevention and treatment of osteoporosis
(Source: Endocrine)
Source: Endocrine - September 18, 2018 Category: Endocrinology Source Type: research

Treatment and outcomes in pheochromocytomas and paragangliomas: a study of 110 cases from a single center
ConclusionThe outcomes seemed slightly better than previous studies. Long-term prognosis was similar between pheochromocytomas and paragangliomas. (Source: Endocrine)
Source: Endocrine - September 15, 2018 Category: Endocrinology Source Type: research

Linking obesity-induced leptin-signaling pathways to common endocrine-related cancers in women
The objective of this review is to highlight the need for novel experimental approaches and a better understanding of the common and unique pathways to resolve controversies regarding the role of obesity in cancer. In women, there is a link between hormones and obesity-associated genes in cancer development. Leptin is an obesity-associated gene that has been studied extensively in cancers; however, whether the defect is in the leptin gene or in its signaling pathways remains unclear. Both leptin and its receptor have been positively correlated with cancer progression in some endocrine-related cancers in women. This review ...
Source: Endocrine - September 14, 2018 Category: Endocrinology Source Type: research

Impulse control disorders in patients with prolactinoma receiving dopamine agonist therapy: a prospective study with 1 year follow-up
AbstractObjectiveTo assess prospectively the prevalence of impulse control disorders (ICD), psychiatric symptoms, and their clinical correlates in patients with prolactinoma receiving dopamine agonists (DA) in comparison to those with non-functioning pituitary adenomas (NFA) and healthy controls (HC).MethodsA total of 25 patients with prolactinoma, 31 with NFA, and 32 HCs were included in the study. All patients and controls were screened for the presence of ICDs and other psychiatric disorders using revised version of Minnesota Impulsive Disorders Interview (MIDI-R), Barratt Impulsiveness Scale (BIS-11), Symptom Check Lis...
Source: Endocrine - September 11, 2018 Category: Endocrinology Source Type: research

Volumetric and texture analysis of pretherapeutic 18 F-FDG PET can predict overall survival in medullary thyroid cancer patients treated with Vandetanib
ConclusionsThe TF Complexity and the volumetric parameter TLG are both independent parameters for OS prediction. (Source: Endocrine)
Source: Endocrine - September 11, 2018 Category: Endocrinology Source Type: research

Dynamic changes in the distribution of facial and abdominal adipose tissue correlated with surgical treatment in acromegaly
ConclusionThe perioperative dynamic distribution of the facial and abdominal fat in acromegaly revealed regional differences in the intricate effect of GH on adipose tissue. Reduction of serum GH after surgical treatment of acromegaly was associated with dynamic increases of IHL, abdominal visceral, and subcutaneous fat, but a reduction of facial subcutaneous fat. (Source: Endocrine)
Source: Endocrine - September 10, 2018 Category: Endocrinology Source Type: research

Single and multiple ascending-dose study of glucagon-receptor antagonist RN909 in type 2 diabetes: a phase 1, randomized, double-blind, placebo-controlled trial
ConclusionRN909 was well tolerated after single and multiple doses in T2DM subjects, with diarrhea and elevated LFTs the most frequent adverse events. The appearance of ADA did not affect pharmacokinetics or efficacy. Robust lowering of FPG and HbA1c was observed. (Source: Endocrine)
Source: Endocrine - September 10, 2018 Category: Endocrinology Source Type: research

Ectopic thyroids have lower computed tomography attenuation values than orthotopic thyroids
ConclusionsEctopic thyroids have lower CT attenuation values than orthotopic thyroids probably due to the structural or functional abnormalities. The dysgenesis and pathological changes of the ectopic thyroids may contribute to functional deficiency which finally leads to decrease of the CT attenuation values. (Source: Endocrine)
Source: Endocrine - September 10, 2018 Category: Endocrinology Source Type: research

Impaired glucagon secretion in patients with fulminant type 1 diabetes mellitus
ConclusionsThese results suggest that glucagon secretion is impaired in patients with FT1DM. (Source: Endocrine)
Source: Endocrine - September 10, 2018 Category: Endocrinology Source Type: research

Correction to: Adrenocortical incidentalomas and bone: from molecular insights to clinical perspectives
The original version of this article unfortunately contained a mistake in Figure 1. There is a typo in the word “osteoclastogenesis” and the word “activity” is missing in the same entity. It should be “osteoclastogenesis” instead of “osteoclestogenesis”. (Source: Endocrine)
Source: Endocrine - September 10, 2018 Category: Endocrinology Source Type: research

Association between age at menopause and fracture risk: a systematic review and meta-analysis
ConclusionsThis is the first meta-analysis showing that EM is associated with increased fracture risk compared with normal age at menopause, without any distinct effect on the site of the fracture. (Source: Endocrine)
Source: Endocrine - September 10, 2018 Category: Endocrinology Source Type: research

Assessment of hair cortisol in euthyroid, hypothyroid, and subclinical hypothyroid subjects
This study aimed to assess the hair cortisol levels as a long-term activity of HPA axis in hypothyroid, SCH and a group of healthy adult subjects. Also, it aimed to examine the correlation of hair cortisol levels with hypothalamic-pituitary-thyroid (HPT) axis and anthropometric measures.MethodsWe prospectively evaluated a group of normal, SCH and hypothyroid subjects. Serum TSH, FT4, and FT3 were measured as a component of the HPT axis. Hair samples were collected, prepared, followed by extraction of hair cortisol and measurement in pg/mg of hair. Hair cortisol levels were compared in normal, SCH and hypothyroid groups and...
Source: Endocrine - September 6, 2018 Category: Endocrinology Source Type: research

Interactions between hypothalamic pituitary thyroid axis and other pituitary dysfunctions
AbstractCentral hypothyroidism is defined as low circulating free thyroxine (free T4) with inappropriately low circulating thyrotropin (TSH), in context of a hypothalamic pituitary pathology. Rare cases of idiopathic central hypothyroidism caused by a functional defect may occur, and the condition is often overlooked due to difficulty in achieving the correct diagnosis, sparse symptomatology of the condition and a high risk of misinterpretion of the biochemical changes in central hypothyroidism. Central hypothyroidism is mainly seen in patients with hypothalamic –pituitary pathology due to one of many possible aetiol...
Source: Endocrine - September 6, 2018 Category: Endocrinology Source Type: research

Oral glucose load and mixed meal feeding lowers testosterone levels in healthy eugonadal men
ConclusionA glucose load or a mixed meal transiently, but significantly, lowers TT levels in healthy, non-diabetic eugonadal men. These findings support the recommendations that measurement of serum testosterone to diagnose androgen deficiency should be performed while fasting. (Source: Endocrine)
Source: Endocrine - September 6, 2018 Category: Endocrinology Source Type: research

Alterations in levels of intermediate-chained acylcarnitines associate with weight-gain following reestablishment of euthyroidism in Graves ’ disease
(Source: Endocrine)
Source: Endocrine - September 3, 2018 Category: Endocrinology Source Type: research

Primary adrenal insufficiency due to bilateral infiltrative disease
ConclusionIn patients with newly diagnosed PAI, the differential diagnosis should include bilateral infiltrative adrenal disease, especially when testing for autoimmune adrenalitis is negative, or if there is clinical history suggesting another etiology. Patients who present with known bilateral adrenal infiltrative disease should be counseled and tested for PAI periodically, particularly if presenting with suggestive signs or symptoms. (Source: Endocrine)
Source: Endocrine - September 3, 2018 Category: Endocrinology Source Type: research

Intraoperative intermittent neuromonitoring of inferior laryngeal nerve and staged thyroidectomy: our experience
ConclusionHigh sensitivity and specificity values confirm the validity of I-IONM with NSLP in predicting postoperative normal vocal cord function. Our results confirm that I-IONM may safely guide an ST overall in benign thyroid diseases and in low-grade malignancies. (Source: Endocrine)
Source: Endocrine - September 1, 2018 Category: Endocrinology Source Type: research

The co-activator-associated arginine methyltransferase 1 (CARM1) gene is overexpressed in type 2 diabetes
ConclusionsIncreased CARM1 expression in type 2 diabetes suggests that epigenetic mechanisms are altered in human diabetes. The impact of lifestyle and pharmacological treatment on regulation of this enzyme should be further investigated. (Source: Endocrine)
Source: Endocrine - September 1, 2018 Category: Endocrinology Source Type: research

The relationship between quality of life, cognition, and thyroid status in Graves ’ disease
ConclusionsAn impairment in QoL among patients with active GD was evidenced, even in those receiving thionamides and in euthyroidism. Ophthalmopathy was a factor associated with a poor QoL and no clear evidence of cognitive impairment was demonstrated. (Source: Endocrine)
Source: Endocrine - September 1, 2018 Category: Endocrinology Source Type: research

Giant pituitary adenoma: histological types, clinical features and therapeutic approaches
AbstractGiant pituitary adenomas comprise about 6 –10% of all pituitary tumors. They are mostly clinically non-functioning adenomas and occur predominantly in males. The presenting symptoms are usually secondary to compression of neighboring structures, but also due to partial or total hypopituitarism. Functioning adenomas give rise to specific s ymptoms of hormonal hypersecretion. The use of dopamine agonists is considered a first-line treatment in patients with giant macroprolactinomas. Somatostatin analogs can also be used as primary treatment in cases of growth hormone and thyrotropin producing giant adenomas, al...
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Serum calcitonin gene-related peptide facilitates adipose tissue lipolysis during exercise via PIPLC/IP3 pathways
ConclusionsEpididymal fat pads is a metabolic target for CGRP during exercise and CGRP effects on adipose tissue metabolism during exercise could be related to PIPLC/IP3 pathway. (Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Epidemiology of acromegaly in Italy: analysis from a large longitudinal primary care database
AbstractPurposeEpidemiological data are pivotal for the estimation of disease burden in populations.AimOf the study was to estimate the incidence and prevalence of acromegaly in Italy along with the impact of comorbidities and hospitalization rates as compared to the general population.MethodsRetrospective epidemiological study (from 2000 to 2014) and case control-study. Data were extracted from the Health Search Database (HSD). HSD contains patient records from about 1000 general practitioners (GPs) throughout Italy, covering a population of more than 1 million patients. It includes information about patient demographics ...
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

TERTp mutation is associated with a shorter progression free survival in patients with aggressive histology subtypes of follicular-cell derived thyroid carcinoma
ConclusionsTERTp mutation appears be an indicator of both persistence and progression of structural disease after initial therapy in aggressive variants of TCDFC, and associates with a shorter progression free survival regardless of the therapy employed. (Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Assessing the utility of preoperative serum thyroglobulin in differentiated thyroid cancer: a retrospective cohort study
AbstractPurposeSerum thyroglobulin (TG) is used to monitor for recurrence or progression of differentiated thyroid cancer (DTC). The role of preoperative TG measurement is more ambiguous, yet still being used in some centers. We aimed to determine whether preoperative TG correlates with disease stage or metastatic burden.MethodsA retrospective review of patients with TG measured before thyroidectomy was conducted. Data collected included demographics, preoperative TG, pathology, and cancer stage. Associations between preoperative TG levels and size of largest malignant nodule, thyroid gland size, stage of cancer, and prese...
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

The posterior pharyngeal wall thickness is associated with OSAHS in patients with acromegaly and correlates with IGF-1 levels
ConclusionsOSAHS is a common complication in patients with untreated acromegaly, and advanced age is a risk factor. Posterior pharyngeal soft tissue thickening and soft palate hypertrophy are structural changes underlying OSAHS development in patients with acromegaly. Higher IGF-1 levels predict an increase in the posterior pharyngeal soft tissue thickness in patients with acromegaly. (Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Pituitary surgery is becoming more common: does this reflect a change in tumor incidence, detection, or treatment pattern?
(Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Role of the ubiquitin/proteasome system on ACTH turnover in rat corticotropes
ConclusionsWe provide the first evidence that the ubiquitin-proteasome system is involved in proopiomelanocortin/ACTH degradation in corticotropes. Indeed, proopiomelanocortin is a target of ubiquitylation and modulation of ubiquitin-proteasome system affects ACTH turnover. This study shows that regulation of ACTH proteolytic degradation may represent a means to control ACTH secretion. (Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Patients ’ knowledge about the outcomes of thyroid biopsy: a patient survey
ConclusionsAfter undergoing thyroid biopsy, a high proportion of well-educated patients remained unaware of their risk for thyroid cancer, potential outcomes, and downstream consequences of their biopsy. This quality gap raises the possibility that informed consent procedures that meet legal standards may leave patients undergoing thyroid biopsy paradoxically uninformed. (Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Incidence and management of postoperative hyperglycemia in patients undergoing insulinoma resection
ConclusionsHyperglycemia is common after insulinoma resection, and a subset of patients require transient treatment with insulin. (Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Pituitary in black —hypopituitarism secondary to hemosiderosis
(Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Lack of functional remission in Cushing ’s syndrome
ConclusionPatients in biological remission of hypercortisolism can rarely be considered as functionally cured: this is evidenced by altered quality of life, working arrangements, and chronic depression. A multidisciplinary management of these patients is thus mandatory on a long-term basis. (Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Survival of aggressive variants of papillary thyroid carcinoma in patients under 55 years old: a SEER population-based retrospective analysis
AbstractBackgroundPatients younger than 55 years of age with papillary thyroid carcinoma (PTC) have excellent survival. Diffuse sclerosing variant (DSV) and tall cell variant (TCV) of PTC are associated with aggressiveness; the survival of patients
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Does the ACR TI-RADS scoring allow us to safely avoid unnecessary thyroid biopsy? single center analysis in a large cohort
In this study, we focused on nodules for which no biopsy is recommended by the ACR Thyroid Imaging, Reporting and Data System (TI-RADS) guideline.Subjects and methodsTwo-thousand eight-hundred and forty-seven consecutive patients with thyroid nodules who underwent FNAB according to the 2009 American Thyroid Association (ATA) guideline were included. The nodules were re-classified according to the ACR TI-RADS guideline as benign (TR1), not suspicious (TR2), mildly suspicious (TR3), moderately suspicious (TR4) and highly suspicious (TR5). The TR3 category was stratified into two subcategories as regard to the nodule size (TR3;
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

More sugar? No, thank you! The elusive nature of low carbohydrate diets
AbstractIn the past decades, dietary guidelines focused on reducing saturated fat as the primary strategy for cardiovascular disease prevention, neglecting the many other potential effects of diet on health, in particular the harmful effects of sugar. A greater intake of soft drinks (sugar-sweetened beverages), for example, is associated with a 44% increased prevalence of metabolic syndrome, a higher risk of obesity, and a 26% increased risk of developing diabetes mellitus. Carbohydrates comprise around 55% of the typical western diet, ranging from 200 to 350  g/day in relation to a person’s overall caloric in...
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research

Additions of neural monitoring for thyroid surgery
(Source: Endocrine)
Source: Endocrine - August 21, 2018 Category: Endocrinology Source Type: research