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Intermittent administration of PTH induces the expression of osteocalcin and BMP-2 on choroid plexus cells associated with suppression of sclerostin, TGF- β1, and Na + K + ATPase
(Source: Endocrine)
Source: Endocrine - December 12, 2017 Category: Endocrinology Source Type: research

Predictors of improvement in bone mineral density after celiac disease diagnosis
ConclusionBMD increases at the lumbar spine after the diagnosis of CD and greater BMD improvement is associated with lower baseline serum calcium. This suggests that those with the lowest calcium, which is likely a surrogate for the greatest malabsorption, may have the greatest potential for improvement in skeletal health after treatment of CD. (Source: Endocrine)
Source: Endocrine - December 11, 2017 Category: Endocrinology Source Type: research

Quality of life and growth after childhood craniopharyngioma: results of the multinational trial  KRANIOPHARYNGEOM 2007
ConclusionsParents assess QoL in CP survivors worse than their children. GH substitution should be considered as a therapeutic option to ameliorate imminent impairments of QoL after CP. (Source: Endocrine)
Source: Endocrine - December 11, 2017 Category: Endocrinology Source Type: research

MassARRAY-based simultaneous detection of hotspot somatic mutations and recurrent fusion genes in papillary thyroid carcinoma: the PTC-MA assay
ConclusionsThe PTC-MA assay is a novel MA test, which is able to detect fusion genes generated by genomic rearrangements concomitantly with the analysis of hotspot point mutations, thus allowing the evaluation of key diagnostic, prognostic, and therapeutic markers of PTC in a single experiment without any informatics analysis. As the assay is sensitive, robust, easily achievable, and affordable, it is suitable for the diagnostic practice. Finally, the PTC-MA assay can be easily implemented and updated by adding novel genetic markers, according to clinical requirements. (Source: Endocrine)
Source: Endocrine - December 6, 2017 Category: Endocrinology Source Type: research

Use of 111In-pentetreotide scintigraphy for diagnosis and management of resistant macroprolactinoma
(Source: Endocrine)
Source: Endocrine - December 6, 2017 Category: Endocrinology Source Type: research

Triiodothyronine differentially modulates the LH and FSH synthesis and secretion in male rats
This study shows that T3 acts on gonadotrophs, resulting in direct effects on LH and FSH synthesis/secretion of male rats, suggesting that some reproductive disorders observed in men may be associated with thyroid hormone imbalances. (Source: Endocrine)
Source: Endocrine - December 5, 2017 Category: Endocrinology Source Type: research

Should subcentimeter non-invasive encapsulated, follicular variant of papillary thyroid carcinoma be included in the noninvasive follicular thyroid neoplasm with papillary-like nuclear features category?
ConclusionPapillary thyroid microcarcinoma, NI-EFV, when stringently selected for, lacks metastasis at presentation and follows an extremely indolent clinical course, even when treated conservatively without RAI therapy. Provided stringent inclusion criteria are met, classification of subcentimeter mPTC, NI-EFV as NIFTP should be considered in order to avoid overtreatment of these biologically indolent lesions. (Source: Endocrine)
Source: Endocrine - December 4, 2017 Category: Endocrinology Source Type: research

Hyperthyroid patients without Graves' orbitopathy are not at increased risk of developing glaucoma: a nationwide Danish register-based case-control study
ConclusionsNeither prior to nor following the diagnosis of GD and TNG had any significant association with glaucoma. (Source: Endocrine)
Source: Endocrine - December 2, 2017 Category: Endocrinology Source Type: research

Impact of thyroid disease on testicular function
ConclusionsIn view of the high prevalence of thyrotoxicosis and hypothyroidism, a considerable part of infertile patients may harbor overt or subclinical thyroid disease. Identification and management of thyrotoxicosis/hypothyroidism associated infertility needs the collaboration of andrologists, endocrinologists, gynecologists, and general practitioners. (Source: Endocrine)
Source: Endocrine - November 17, 2017 Category: Endocrinology Source Type: research

Somatostatin receptor subtype 1 might be a predictor of better response to therapy in medullary thyroid carcinoma
ConclusionThis is the first study to show the correlation of the presence of SSTR1, detected by monoclonal immunohistochemical techniques, and better response to initial treatment and possibly better long-term clinical response in patients with MTC. In addition, these patients had low positivity rates for SSTR2, which might explain the low sensitivity of diagnostic and limited therapeutic response to octrotide based radioisotopes. (Source: Endocrine)
Source: Endocrine - November 17, 2017 Category: Endocrinology Source Type: research

Changes in bone mineral density related to changes in serum 25-OH vitamin D concentrations over a two-year period in postmenopausal women
(Source: Endocrine)
Source: Endocrine - November 17, 2017 Category: Endocrinology Source Type: research

The tear cytokine profile in patients with active Graves ’ orbitopathy
ConclusionsLow concentrations of IL-7 in tears exhibit specificity for active GO in patients nearly 2 years from the clinical onset of activity. Although using IL-7 in tears as a biomarker for disease activity may be limited due to its late manifestation, targeting immune restitution using IL-7 may have disease modifying effects. (Source: Endocrine)
Source: Endocrine - November 16, 2017 Category: Endocrinology Source Type: research

Oxidative stress in adult growth hormone deficiency: different plasma antioxidant patterns in comparison with metabolic syndrome
AbstractBackground and aimsGrowth hormone deficiency (GHD) is a condition associated with increased cardiovascular risk and insulin-resistance. Oxidative stress (OS) could be a mechanism underlying both these phenomena. In order to investigate plasma antioxidant defenses in such condition, we evaluated adults with GHD, compared with controls and metabolic syndrome patients (MetS), studying plasma total antioxidant capacity (TAC) and coenzyme Q10 (CoQ10, lipophilic antioxidant) levels, both in its oxidized and reduced forms, correlating this data with metabolic and hormonal pattern.Materials and methodsIn this case-control ...
Source: Endocrine - November 15, 2017 Category: Endocrinology Source Type: research

Diagnostic work-up in steroid myopathy
ConclusionsWe suggest that the management of steroid myopathy patients in clinical research and practice would benefit from a multidisciplinary approach based on the combined assessment of muscle mass, strength, and performance. However, further studies are required to establish an operational definition of steroid myopathy and to identify population-specific criteria for diagnosis of the myopathic process. (Source: Endocrine)
Source: Endocrine - November 15, 2017 Category: Endocrinology Source Type: research

Sexual function and sex hormones in breast cancer patients
ConclusionsBCP are at high risk of developing FSD both for treatment choice and hormonal status, but they have not sexually related personal distress. (Source: Endocrine)
Source: Endocrine - November 14, 2017 Category: Endocrinology Source Type: research

PRMT1 promotes hyperglycemia in a FoxO1-dependent manner, affecting glucose metabolism, during hypobaric hypoxia exposure, in rat model
ConclusionsPRMT1 might have a potential importance as a therapeutic target for the treatment of HH-induced maladies. (Source: Endocrine)
Source: Endocrine - November 11, 2017 Category: Endocrinology Source Type: research

Dopamine agonist withdrawal in hyperprolactinemia: when and how
(Source: Endocrine)
Source: Endocrine - November 9, 2017 Category: Endocrinology Source Type: research

A functional assessment of anatomical variants of the recurrent laryngeal nerve during thyroidectomies using neuromonitoring
AbstractPurposeThe aim of the study was to assess the usefulness of intraoperative neuromonitoring (IONM) in identifying anatomical variants of the recurrent laryngeal nerve (RLN) during thyroidectomies, with emphasis on the nerve ’s relationship to the inferior thyroid artery (ITA), Zuckerkandl’s tubercle, nonrecurrent laryngeal nerves (NRLNs), and extralaryngeal bifurcation.MethodsA total of 128 subjects undergoing surgery for thyroid disorders were enrolled in the study, and the course and anatomical variants of RLN were assessed with IONM application.ResultsThe standard relationship between RLN and ITA was ...
Source: Endocrine - November 8, 2017 Category: Endocrinology Source Type: research

Long-term safety of long-acting octreotide in patients with diabetic retinopathy: results of pooled data from 2 randomized, double-blind, placebo-controlled phase 3 studies
ConclusionsThe results from these long-term placebo-controlled studies confirm the established safety profile of long-acting OCT, in particular low risk of cardiac, hepatic and renal toxicity in a high-risk population. (Source: Endocrine)
Source: Endocrine - November 7, 2017 Category: Endocrinology Source Type: research

Real-life management and outcome of thyroid carcinoma-related bone metastases: results from a nationwide multicenter experience
AbstractPurpose and PatientsThe M.O.S.CA.TI. (Metastases of the Skeleton from CArcinoma of the ThyroId) is a multicenter, retrospective study investigating the real-life outcome and management of bone metastases (BM) in 143 patients (63 M, 80 F; median age 64 years, range 11 –87) with differentiated thyroid carcinoma (DTC).ResultsRadio-active iodine (RAI) treatment was performed in 131 patients (91.6%), surgical approach and/or external radiotherapy in 68 patients (47.6%), and anti-resorptive bone-active drugs in 32 patients (22.4%; in 31 zoledronate and in one denosumab). At the start of treatment, 24 patients (75.0...
Source: Endocrine - November 6, 2017 Category: Endocrinology Source Type: research

Trends in surgery, hospital admissions and imaging for pituitary adenomas in Australia
AbstractPurposeThere is a paucity of epidemiological information on treatment and imaging of pituitary adenomas in Australia.MethodsAustralian data on pituitary surgery, hospital admissions for pituitary adenomas, and pituitary imaging on patients 15 years and over were obtained from administrative databases between 2000/2001 and 2014/2015. Changes over time and by age and sex were assessed.ResultsIn 2014/15 there were 37.7 pituitary procedures/million population, corresponding to a 35.4% (p 
Source: Endocrine - November 4, 2017 Category: Endocrinology Source Type: research

The effects of Exendin-4 on bone marrow-derived mesenchymal cells
ConclusionsOur data suggest a complex action of EXE on bone, targeting the proliferation of mesenchymal progenitors, the metabolism of mature adipocytes and the modulation of osteoclastogenesis. Thus, an overall positive effect of this molecule on bone quality might be hypothesised. (Source: Endocrine)
Source: Endocrine - November 1, 2017 Category: Endocrinology Source Type: research

Efficacy of dexamethasone suppression test during the diagnosis of primary pigmented nodular adrenocortical disease in Chinese adrenocorticotropic hormone-independent Cushing syndrome
AbstractObjectiveTo evaluate the cut-off value of the ratio of 24  h urinary free cortisol (24 h UFC) levels post-dexamethasone to prior-dexamethasone in dexamethasone suppression test (DST) during the diagnosis of primary pigmented nodular adrenocortical disease in Chinese adrenocorticotropic hormone-independent Cushing syndrome.DesignRetrospective study.ParticipantsThe patients diagnosed with primary pigmented nodular adrenocortical disease (PPNAD,n = 25), bilateral macronodular adrenal hyperplasia (BMAH,n = 27), and adrenocortical adenoma (ADA,n = 84) were admitted...
Source: Endocrine - November 1, 2017 Category: Endocrinology Source Type: research

Effect of thyroid hormone suppression on control of advanced well-differentiated thyroid cancer
(Source: Endocrine)
Source: Endocrine - November 1, 2017 Category: Endocrinology Source Type: research

Metformin effect on TSH in subclinical hypothyroidism: randomized, double-blind, placebo-controlled clinical trial
ConclusionSince the sample size was small, the study was inconclusive and the results should be considered preliminary data of a study that needs to enroll 1626 patients to show a 0.5  mIU/L difference in TSH between the groups, with 90% power. (Source: Endocrine)
Source: Endocrine - October 27, 2017 Category: Endocrinology Source Type: research

PI3K/Akt/mTOR pathway involvement in regulating growth hormone secretion in a rat pituitary adenoma cell line
ConclusionOur data confirm that mTOR inhibitors may be useful to reduce pituitary adenoma cell viability, while Erk 1/2 pathway may be considered as a useful therapeutic target to control GH secretion. Our results open the field for further studies searching for effective drugs to control GH hyper-secretion. (Source: Endocrine)
Source: Endocrine - October 27, 2017 Category: Endocrinology Source Type: research

Specific plasma amino acid disturbances associated with metabolic syndrome
ConclusionsMS is associated with selective BCAA and AAA profile disturbances, which could be part of cardiometabolic disease pathogenesis and derive neither directly from insulin sensitivity impairment, nor obesity or muscle mass. The MS diagnostic model developed and described herein should be validated in future studies. (Source: Endocrine)
Source: Endocrine - October 26, 2017 Category: Endocrinology Source Type: research

Lugol ’s solution and other iodide preparations: perspectives and research directions in Graves’ disease
AbstractLugol ’s solution and other preparations containing iodide have for almost a century been used as an adjuvant treatment in patients with Graves’ disease planned for thyroidectomy. Iodide has been shown to decrease thyroid hormone levels and reduce blood flow within the thyroid gland. An escape phenome non has been feared as the iodide effect has been claimed to only be temporary. Lugol’s solution has many additional effects and is used in other settings beside the thyroid. Still, there are questions of its mode of action, which doses should be deployed, if it should be used preoperative in all thy...
Source: Endocrine - October 26, 2017 Category: Endocrinology Source Type: research

Diabetes: the disease of the 10 D
(Source: Endocrine)
Source: Endocrine - October 26, 2017 Category: Endocrinology Source Type: research

Comment on 'Association between serum osteocalcin and body mass index: a systematic review and meta-analysis.'
(Source: Endocrine)
Source: Endocrine - October 25, 2017 Category: Endocrinology Source Type: research

Physiological serum 25-hydroxyvitamin D concentrations are associated with improved thyroid function —observations from a community-based program
ConclusionThe results of the current study suggest that optimal thyroid function might require serum 25(OH)D concentrations above 125 nmol/L. Vitamin D supplementation may offer a safe and economical approach to improve thyroid function and may provide protection from developing thyroid disease. (Source: Endocrine)
Source: Endocrine - October 24, 2017 Category: Endocrinology Source Type: research

Microsurgical therapy of pituitary adenomas
ConclusionsIn experienced hands, transsphenoidal microsurgery for PAs achieves remission in most patients with a low complication rate. Pituitary function is preserved in most cases and can recover in more than one-third of patients with preoperative hypopituitarism. (Source: Endocrine)
Source: Endocrine - October 24, 2017 Category: Endocrinology Source Type: research

A novel homozygous 1-bp deletion in the NOBOX gene in two Brazilian sisters with primary ovarian failure
ConclusionWe report the first familial case of a novel homozygousNOBOX variant with an autosomal recessive mode of inheritance, thus allowing for a genetic diagnosis of primary ovarian failure. (Source: Endocrine)
Source: Endocrine - October 24, 2017 Category: Endocrinology Source Type: research

Pre-admission TSH levels predict long-term mortality in adults treated for hypothyroidism
AbstractContextLimited data is available regarding the association between pre-admission thyroid function and prognosis of hospitalized patients treated for hypothyroidism.ObjectiveEvaluate an association between thyroid stimulating hormone (TSH) levels and mortality in hospitalized levothyroxine-treated patients.Design and settingObservational data of patients admitted to medical wards between 2011 and 2013. TSH levels obtained up to 180 days prior to admission were stratified as follows: low ( ≤0.5 mIU/L), normal (0.5–5 mIU/L), high (>5  mIU/L).PatientsPatients aged 60 –80 years wit...
Source: Endocrine - October 20, 2017 Category: Endocrinology Source Type: research

Probiotic strains and mechanistic insights for the treatment of type 2 diabetes
ConclusionA major obstacle in the evaluation of probiotic strains lays in the great number of strains, differences in detection methodology and measured outcome parameters. The understanding of further research should be directed towards the development of standardized evaluation methods to facilitate the comparison of different studies. (Source: Endocrine)
Source: Endocrine - October 19, 2017 Category: Endocrinology Source Type: research

HMGA1 is a novel transcriptional regulator of the FoxO1 gene
ConclusionThese findings may contribute to the understanding ofFoxO1 gene regulation and its role in metabolism. (Source: Endocrine)
Source: Endocrine - October 19, 2017 Category: Endocrinology Source Type: research

Thyroid reoperation using intraoperative neuromonitoring
AbstractPurposeThyroid reoperations are at a high risk of recurrent laryngeal nerve (RLN) injury. The aim of the study was to investigate whether the use of intraoperative neuromonitoring(IONM) can aid in the RLN identification and minimize the risk of its injury, in comparison with visual RLN identification.MethodsThis was a retrospective cohort study of patients who underwent thyroid reoperations with and without the use of IONM. Primary endpoint was the RLN identification rate; secondary: the prevalence of RLN injury, the frequency of total thyroidectomies, and the course of the RLN.ResultsThe study involved 61 patients...
Source: Endocrine - October 19, 2017 Category: Endocrinology Source Type: research

Effectiveness of myoinositol for polycystic ovary syndrome: a systematic review and meta-analysis
ConclusionBased on current evidence, myoinositol may be recommended for the treatment of PCOS with insulin resistance, as well as for improving symptoms caused by decreased estrogen in PCOS. (Source: Endocrine)
Source: Endocrine - October 19, 2017 Category: Endocrinology Source Type: research

Optimal timing of dopamine agonist withdrawal in patients with hyperprolactinemia: a systematic review and meta-analysis
ConclusionThe success rate of DA withdrawal has increased in recent years. Further, the success rate of CAB withdrawal was higher than that of bromocriptine, especially in patients with a duration of treatment longer than 24 months. Conclusively, the probability of success was higher in patients who received low-dose CAB maintenance treatment and those who achieved a significant reduction in tumor size before withdrawal. (Source: Endocrine)
Source: Endocrine - October 17, 2017 Category: Endocrinology Source Type: research

Clinical profile of silent growth hormone pituitary adenomas; higher recurrence rate compared to silent gonadotroph pituitary tumors, a large single center experience
ConclusionThis is the largest single center study characterizing SGHA behavior with SGA and SCA control groups in a cohort of surgically resected pituitary adenomas. SGHA present mostly in young females, and should be closely followed due to their higher likelihood of recurrence and potential of progression to clinical acromegaly. We propose that a complete hormonal staining panel be routinely performed for all pituitary adenomas. (Source: Endocrine)
Source: Endocrine - October 17, 2017 Category: Endocrinology Source Type: research

Nonfunctioning adrenal incidentaloma affecting central blood pressure and arterial stiffness parameters
ConclusionsNFAIs are known as cardiometabolically innocent, but in our study, both peripheral and central blood pressure values and arterial stiffness parameters were negatively affected in patients diagnosed with NFAI who have no traditional cardiovascular risk factors. These patients are at risk of cardiovascular diseases. (Source: Endocrine)
Source: Endocrine - October 17, 2017 Category: Endocrinology Source Type: research

Estrogen-based hormone therapy in women with primary ovarian insufficiency: a systematic review
ConclusionsEvidence supporting bone and cardiovascular benefits of HT in women with POI is limited by high risk of bias, reliance on surrogate outcomes, and heterogeneity of trials regarding the formulation, dose, route of administration, and regimen of HT. Further research addressing patient important outcomes such as fractures, stroke, and cardiovascular mortality are crucial to optimize benefits of this therapy. (Source: Endocrine)
Source: Endocrine - October 16, 2017 Category: Endocrinology Source Type: research

Heritability of Addison ’s disease and prevalence of associated autoimmunity in a cohort of 112,100 Swedish twins
ConclusionsThe heritability of AAD appears to be very high, emphasizing the need for further research on the genetic etiology of the disease. Monozygotic twin concordance for multiple autoimmune manifestations suggests strong genetic influence on disease specificity in organ-specific autoimmunity. (Source: Endocrine)
Source: Endocrine - October 16, 2017 Category: Endocrinology Source Type: research

Adiponectin circulating levels and 10-year (2002 –2012) cardiovascular disease incidence: the ATTICA Study
ConclusionsIn our study, elevated circulating total adiponectin levels were associated with lower 10-year CVD risk in adults without previous CVD, independently of other established CVD risk factors. This association appeared to be modestly attenuated by CRP, yet was not mediated by interleukin-6 which is the main endocrine/circulating pro-inflammatory cytokine. (Source: Endocrine)
Source: Endocrine - October 16, 2017 Category: Endocrinology Source Type: research

Transoral endoscopic thyroidectomy via a vestibular approach: why and how?
AbstractThe transoral endoscopic thyroidectomy vestibular approach (TOETVA) is a novel, scar-free surgical procedure that does not require visible incisions. Indications for TOETVA are as follows: predicted gland width on diagnostic imaging ≤10 cm; a thyroid volume outline of45  mL or main nodule diameter of>50  mm; and documentation of lymph node or distant metastases, tracheal/esophageal infiltration, preoperative laryngeal nerve palsy, hyperthyroidism, mediastinal goiter, or an oral abscess. Patients with poorly differentiated or un-differentiated cancer, dorsal extrathyroidal radius, and/or l...
Source: Endocrine - October 16, 2017 Category: Endocrinology Source Type: research

Bilateral Tolosa-Hunt syndrome mimicking pituitary adenoma
AbstractThe authors report a rare case of bilateral Tolosa-Hunt syndrome, which occurred in a 80-year-old female and remitted spontaneously. Inflammatory lesions were found not only in typical locations, i.e. superior orbital fissures and cavernous sinuses, but also in the pituitary; these imitated gland ’s macroadenoma in imaging studies. (Source: Endocrine)
Source: Endocrine - October 14, 2017 Category: Endocrinology Source Type: research

Improvement in pregnancy outcomes in couples with immunologically male infertility undergoing prednisolone treatment and conventional in vitro fertilization preceded by sperm penetration assay: a randomized controlled trial
This study was therefore designed to define factors contributing to these inconsistent results.MethodsInfertile men having ASA (n = 241) were randomly assigned for treatment with or without prednisolone for three cycles each of 21 days of their partner’s menstrual cycles. Control and treated men underwent then human sperm penetration assay (SPA), of hamster oocytes, to diagnose men with impaired sperm fusogenic capacity . Men with positive or negative SPA results were admitted to conventional IVF or ICSI programs, respectively.ResultsTreated patients had improved sperm motility and progressive motility ...
Source: Endocrine - October 13, 2017 Category: Endocrinology Source Type: research

Effects of growth hormone therapy on bone density and fracture risk in age-related osteoporosis in the absence of growth hormone deficiency: a systematic review and meta-analysis
ConclusionGH may not improve bone density in women with age-related bone loss but may decrease fracture risk. Larger studies of longer duration are needed to further explore these findings in both genders, and to investigate the effect of GH on bone quality. (Source: Endocrine)
Source: Endocrine - October 13, 2017 Category: Endocrinology Source Type: research

Outcome prediction with the revised American joint committee on cancer staging system and American thyroid association guidelines for thyroid cancer
ConclusionAJCC/UICC 8th edition predicted patient outcome more accurately than the other staging systems. (Source: Endocrine)
Source: Endocrine - October 13, 2017 Category: Endocrinology Source Type: research

The Zollinger-Ellison syndrome: is there a role for somatostatin analogues in the treatment of the gastrinoma?
ConclusionsThe high sstr-expression in gastrinomas make them highly responsive to SSAs and support the use of such drugs to counteract the tumour growth in patients not amenable to surgical cure. Unfortunately, limited data, mainly case reports or small series, support the use of SSAs in advanced gastrinomas, therefore, it is difficult to quantify their ability to control tumour growth and disease progression. (Source: Endocrine)
Source: Endocrine - October 10, 2017 Category: Endocrinology Source Type: research