A key role for conservative treatment in the management of pituitary apoplexy
AbstractPurposeThe management of pituitary apoplexy, a rare emergency neuroendocrine condition, is controversial. The aim of the present study is to compare the outcomes of patients with pituitary apoplexy managed either by a conservative or surgical approach.MethodsA retrospective cohort study including patients diagnosed between 2007 and 2018 in a tertiary French university hospital. Pituitary Apoplexy Score (PAS) was retrospectively applied in the perspective of therapeutic decision support.ResultsForty-six patients were treated for pituitary apoplexy either with conservative management (n = 27) or surgery...
Source: Endocrine - September 21, 2020 Category: Endocrinology Source Type: research

The validity of cost-effectiveness analyses of tight glycemic control. A systematic survey of economic evaluations of pharmacological interventions in patients with type 2 diabetes
ConclusionsReliance on the association between glycemic control and diabetes-related complications evident in observational studies but not apparent in randomized trial bias the estimates of the cost-effectiveness of interventions to improve glycemic control. (Source: Endocrine)
Source: Endocrine - September 21, 2020 Category: Endocrinology Source Type: research

Are women with osteoporosis treated with denosumab at risk of severe COVID-19?
(Source: Endocrine)
Source: Endocrine - September 20, 2020 Category: Endocrinology Source Type: research

Hypeprolactinemia: still an insidious diagnosis
AbstractHyperprolactinemia can have different causes: physiological, pharmacological, and pathological. When investigating the etiology of hyperprolactinemia, clinicians need to be aware of several conditions leading to misdiagnosis. The most popular pitfalls are: acute physical and psychological stress, macroprolactin, hook effect, even though antibodies interferences and biotine use have to be considered. A 52-year-old woman was referred to Endocrinology clinic for oligomenorrhoea and headache. She worked as a butcher. Hormonal evaluation showed very high PRL (305  ng/ml, reference interval:
Source: Endocrine - September 19, 2020 Category: Endocrinology Source Type: research

The role of the tumour microenvironment in the angiogenesis of pituitary tumours
ConclusionsM2 macrophages appear to play a role in PitNET neovascularisation, while B, CD4+ and FOXP3+ lymphocytes, as well as non-cellular TME elements such as CCL2, CXCL10 and CX3CL1, may also modulate the angiogenesis of PitNETs. (Source: Endocrine)
Source: Endocrine - September 18, 2020 Category: Endocrinology Source Type: research

Clinical application of a novel next generation sequencing assay for CYP21A2 gene in 310 cases of 21- hydroxylase congenital adrenal hyperplasia from India
ConclusionsWe have developed and validated a comprehensive NGS-based assay for detection of variants inCYP21A2 gene in patients with 21-OH CAH. We describeCYP21A2 mutation spectrum and novel variants in a large cohort of Indian patients with CAH. (Source: Endocrine)
Source: Endocrine - September 18, 2020 Category: Endocrinology Source Type: research

Correction to: Overexpression of CAV3 facilitates bone formation via the Wnt signaling pathway in osteoporotic rats
An amendment to this paper has been published and can be accessed via a link at the top of the paper. (Source: Endocrine)
Source: Endocrine - September 18, 2020 Category: Endocrinology Source Type: research

Association between metabolic syndrome and gestational diabetes mellitus in women and their children: a systematic review and meta-analysis
AbstractPurposeThe primary aim of this systematic review and meta-analysis was to determine the association between gestational diabetes mellitus (GDM) and metabolic syndrome (MetS) in women and children. Our secondary aim was to assess the development of MetS with respect to the elapsed time postpartum at which MetS was diagnosed.MethodsThis review is registered with PROSPERO (CRD42020173319). PubMed, CINHAL, SCOPUS, and EMBASE databases were searched. Studies reporting on the rate of MetS in pregnant women with GDM, the rate of MetS in women with a history of GDM, and the rate of MetS in offspring exposed to GDM in utero...
Source: Endocrine - September 15, 2020 Category: Endocrinology Source Type: research

Correction to: Dynamics of serum antithyroglobulin antibodies in patients with differentiated thyroid cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper. (Source: Endocrine)
Source: Endocrine - September 14, 2020 Category: Endocrinology Source Type: research

Using The Cancer Genome Atlas data to refine the 8th edition of the American Joint Committee on Cancer staging for papillary thyroid carcinoma
ConclusionsIn the TCGA series, the proportion of deaths is in line with the expected survival of the latest AJCC staging, with a neat separation of risk among stages. Nevertheless, the use of protein expression can be useful in refining the stratification. Finally, after the restaging, a considerable number of tumors withTERT mutations will be allocated in lower stages; hence, dedicated studies should define the prognostic usefulness of these mutations in low-stage diseases. (Source: Endocrine)
Source: Endocrine - September 11, 2020 Category: Endocrinology Source Type: research

Kisspeptin and LH pulsatility in patients with functional hypothalamic amenorrhea
ConclusionsOur study demonstrated the presence of a distinct kisspeptin episodic secretion in patients with FHA, and showed the temporally coupling of kisspeptin with LH secretory episodes thus supporting that though in amenorrhea, the reproductive axis is still relying on kisspeptin to drive GnRH discharge. In addition, correlations among hormonal data sustain the hypothesis that stress-induced compensatory events are the main direct and indirect promoters of the reproductive blockade in patients affected by FHA. (Source: Endocrine)
Source: Endocrine - September 11, 2020 Category: Endocrinology Source Type: research

Clinical features, risk of mass enlargement, and development of endocrine hyperfunction in patients with adrenal incidentalomas: a long-term follow-up study
ConclusionsIn patients with AI, the risk of developing hormonal hyperfunction and mass enlargement is overall low, although some tumor characteristics and anthropometric features might increase this risk. Taking account of all these aspects is important for planning a tailored follow-up in AI patients. (Source: Endocrine)
Source: Endocrine - September 11, 2020 Category: Endocrinology Source Type: research

Comparison of differences in bone microarchitecture in adult- versus juvenile-onset type 1 diabetes Asian males versus non-diabetes males: an observational cross-sectional pilot study
AbstractPurposeEvidence about bone microarchitecture in Asian type 1 diabetes (T1D) patients is lacking. We assessed the bone microarchitecture in T1D patients versus controls and compare the differences between juvenile-onset and adult-onset T1D patients.MethodsThis cross-sectional study recruited 32 Asian males with T1D and 32 age-, sex-, and body mass index (BMI)-matched controls. Dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) for ultradistal nondominant radius and tibia were performed. The data were analyzed using Student ’st test and analysis of c...
Source: Endocrine - September 11, 2020 Category: Endocrinology Source Type: research

Serum anti-M üllerian hormone levels in women are unstable in the postpartum period but return to normal within 5 months: a longitudinal study
ConclusionsThe regulation of AMH secretion appears to be distinctly different in non-pregnant, pregnant and postpartum populations. This may affect the conclusions that can be drawn from AMH measurements in women during pregnancy and the postpartum period. (Source: Endocrine)
Source: Endocrine - September 11, 2020 Category: Endocrinology Source Type: research

Gene expression profile of epithelial-mesenchymal transition mediators in papillary thyroid cancer
ConclusionsWe demonstrate that PDGFRA activates EMT pathways and decreases expression of genes favoring epithelial integrity, pushing follicular cells toward a dedifferentiated phenotype. SPP1 and DPP4, previously linked with adverse outcomes in thyroid cancer, appear to be regulated by PDGFRA. PDGFRA expression promotes metastatic disease through multiple EMT levers that favor formation of an invasive phenotype and increased metalloproteinase expression. (Source: Endocrine)
Source: Endocrine - September 10, 2020 Category: Endocrinology Source Type: research

Polymorphisms of IL-4 and IL-4R are associated to some demographic characteristics of differentiated thyroid cancer patients but are not determinants of risk in the Brazilian population
ConclusionsThese findings indicate that although genetic variants inIL-4 andIL-4R do not influence the risk or outcome of DTC patients, their influence on the behavior of thyroid tumors deserves further investigation. (Source: Endocrine)
Source: Endocrine - September 9, 2020 Category: Endocrinology Source Type: research

Inhibition of the RANKL with denosumab has no effect on circulating markers of atherosclerosis in women with postmenopausal osteoporosis: a pilot study
AbstractPurposeWe evaluated the early effect of denosumab on circulating markers of atherosclerosis in women with postmenopausal osteoporosis.MethodsDenosumab (60  mg) was administered subcutaneously every 6 months (m) in 27 women (mean age 75 ± 5 years) with postmenopausal osteoporosis and high cardiovascular risk for a total of 24 m. Zoledronic acid was administered in 6 age-matched women as a single intravenous dose. Serum levels of vascular cell ad hesion protein 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), E and P selectin, CD-40 ligand (CD40L), interleukin-6 (IL-6), matrix metal...
Source: Endocrine - September 8, 2020 Category: Endocrinology Source Type: research

Correlation between TSH levels and quality of life among subjects with well-controlled primary hypothyroidism
ConclusionsIn patients with primary hypothyroidism, higher TSH values, even within the normal reference range, are associated with greater deterioration of HRQoL. (Source: Endocrine)
Source: Endocrine - September 8, 2020 Category: Endocrinology Source Type: research

Non-glucose risk factors in the pathogenesis of diabetic peripheral neuropathy
AbstractIn this review, we consider the diverse risk factors in diabetes patients beyond hyperglycemia that are being recognized as contributors to diabetic peripheral neuropathy (DPN). Interest in such alternative mechanisms has been encouraged by the recognition that neuropathy occurs in subjects with metabolic syndrome and pre-diabetes and by the reporting of several large clinical studies that failed to show reduced prevalence of neuropathy after intensive glucose control in patients with type 2 diabetes. Animal models of obesity, dyslipidemia, hypertension, and other disorders common to both pre-diabetes and diabetes ...
Source: Endocrine - September 7, 2020 Category: Endocrinology Source Type: research

Efficacy of oral rosuvastatin intervention on HDL and its associated proteins in men with type 2 diabetes mellitus
AbstractPurposeHigh-density lipoprotein (HDL) undergoes structural and functional modification in patients with type 2 diabetes mellitus (T2DM). There are limited data on effect of rosuvastatin on HDL-associated proteins and the antiatherogenic effects of rosuvastatin. The present study intended to study the efficacy of rosuvastatin intervention on HDL-associated proteins and its other antiatherogenic effects in men with T2DM.MethodsMen with T2DM on oral antidiabetic treatment, with LDL-C levels  >  75 mg/dL and willing for rosuvastatin intervention (20 mg/day orally for a period of 12 weeks)...
Source: Endocrine - September 7, 2020 Category: Endocrinology Source Type: research

Thioredoxin-interacting protein: a critical link between autophagy disorders and pancreatic β-cell dysfunction
This study aimed to elucidate the influence of TXNIP on the autophagy of β-cell. In this study, C57BL/6 mice and TXNIP−/− mice were fed with a standard diet (SD) or a high-fat and high-sugar diet (HFSD), and then we analysed biochemical and autophagy related indexes in the mice. We infected MIN6 cells with LV-TXNIP and siRNA TXNIP, then the cells were treated with free fatty acid (FFA), autophagic activator rapamycin (RAP), inhibitors of autophagy chloroquine (CQ) and bafilomycin A1(BAF), finally, we examined the changes of autophagy in MIN6 cells. The results showed that HFSD led to β-cell dysfunctio...
Source: Endocrine - September 6, 2020 Category: Endocrinology Source Type: research

Will 18 F-fluorocholine PET/CT replace other methods of preoperative parathyroid imaging?
ConclusionsDue to the excellent diagnostic performance of radiolabeled choline PET/CT and the low radiation burden, this technique seems to be an ideal candidate to substitute current imaging procedures including US, MIBI scintigraphy, 4D CT and MRI and perform a fast and reliable “one-stop-shop” preoperative localization of HP in patients with PHPT, including challenging cases of postoperative persistent/recurrent disease. (Source: Endocrine)
Source: Endocrine - September 6, 2020 Category: Endocrinology Source Type: research

11 C-metomidate PET in the diagnosis of adrenal masses and primary aldosteronism: a review of the literature
Conclusions11C-metomidate, a selective inhibitor of 11- β-hydroxylase, demonstrated a high specificity for adrenocortical tissue. In addition,11C-metomidate is correlated with this enzyme activity making it a potentially useful PET tracer for the identification primary aldosteronism, in addition to detection of adrenocortical masses. (Source: Endocrine)
Source: Endocrine - September 4, 2020 Category: Endocrinology Source Type: research

Lenvatinib as first-line treatment for advanced thyroid cancer: long progression-free survival
ConclusionIn this series of RAI-R DTC patients, with the unique features to have an ECOG 0 or 1 and to be naive for TKI treatments, PFS was the longest among all real-life published so far, with the highest rate of patients with partial response and one of the lowest drug discontinuation rate for AEs. The correct timing of treatment start, the tailoring of the dose, and a proper management of the AEs may have a significant impact on the treatment response to LEN. (Source: Endocrine)
Source: Endocrine - September 3, 2020 Category: Endocrinology Source Type: research

Relationship of Vitamin D status with testosterone levels: a systematic review and meta-analysis
AbstractPurposeDespite a biological plausibility of a direct link between low vitamin D and androgen deficiency, the association remains inconclusive in epidemiological studies. Therefore, this systematic review and meta-analysis of case-control studies aim to assess whether and in what populations such an association can be demonstrated.MethodsA systematic search was performed in PubMed, EMBASE, Cochrane Library, Web of science, Science Direct, and CINAHL. Standardized mean differences (SMDs) and 95% confidence intervals (CIs) in total testosterone (TT) levels between men with 25-hydroxyvitamin D (25(OH)D)  
Source: Endocrine - September 3, 2020 Category: Endocrinology Source Type: research

Etiology, baseline clinical profile and comorbidities of patients with Cushing ’s syndrome at a single endocrinological center
AbstractPurposeThe aim of this study was to compare phenotype of patients with pituitary, adrenal and ectopic CS and identify the differences regarding biochemical parameters, clinical presentations, and comorbidities in CS patients who were diagnosed at the single endocrinological center in Wroclaw.MethodsThe study population involved 64 patients with CS (53 women and 11 men) diagnosed in Department of Endocrinology, Diabetes and Isotope Therapy in 2000 –2018. Patients were divided into three etiologic groups: pituitary dependent-CS (P-CS) (64%), adrenal dependent CS (A-CS) (25%), and CS from an ectopic source (E-CS...
Source: Endocrine - September 3, 2020 Category: Endocrinology Source Type: research

An analysis of calcium-to-phosphorus ratio in the diagnosis of normocalcemic primary hyperparathyroidism
(Source: Endocrine)
Source: Endocrine - September 3, 2020 Category: Endocrinology Source Type: research

Meta-analytic evidence for increased low-grade systemic inflammation and oxidative stress in hypothyroid patients. Can levothyroxine replacement therapy mitigate the burden?
AbstractPurposeThis series of meta-analyses were aimed to elucidate the impact of hypothyroidism on low-grade systemic inflammation and oxidative stress assessed by C-reactive protein (CRP) and malondialdehyde (MDA) respectively; and to evaluate the effect of levothyroxine replacement therapy (LRT) on those outcomes.MethodsPubMed database and the key studies references were searched prior to March 3, 2020. Data on serum or plasma CRP and MDA levels in SHT (subclinical) and/or OHT (overt) hypothyroid patients and controls were extracted to compute overall standardized mean differences (SMD) by the random-effects model.Resul...
Source: Endocrine - September 2, 2020 Category: Endocrinology Source Type: research

The significance of high thyroxine in hospitalized patients with low thyroid-stimulating hormone
AbstractPurposeThere is scarce data about the interpretation of high thyroid hormone levels in hospitalized patients. We wished to investigate the significance of high thyroxine (T4) in hospitalized patients with low TSH.MethodsWe conducted a retrospective study of data from patients in nonsurgical departments. Three groups of random patients with low TSH were defined and compared: 123 patients with only high FT4 levels (T4 group), 82 with high FT3 levels with or without high FT4 level (T3 group), and 119 with low FT3 and FT4 level in the lower half of the norm and below (NTIS group).ResultsThe primary cause of admission i...
Source: Endocrine - September 2, 2020 Category: Endocrinology Source Type: research

Diabetes mellitus is a risk factor for prolonged SARS-CoV-2 viral shedding in lower respiratory tract samples of critically ill patients
ConclusionIntubated patients with type 2 diabetes mellitus may have prolonged SARS-CoV-2 shedding. In critically ill COVID-19 patients, one negative LTA should be sufficient to assess and exclude infectivity. (Source: Endocrine)
Source: Endocrine - September 1, 2020 Category: Endocrinology Source Type: research

2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS
AbstractThyroid nodules are very common all over the world, and China is no exception. Ultrasound plays an important role in determining the risk stratification of thyroid nodules, which is critical for clinical management of thyroid nodules. For the past few years, many versions of TIRADS (Thyroid Imaging Reporting and Data System) have been put forward by several institutions with the aim to identify whether nodules require fine-needle biopsy or ultrasound follow-up. However, no version of TIRADS has been widely adopted worldwide till date. In China, as many as ten versions of TIRADS have been used in different hospitals...
Source: Endocrine - August 21, 2020 Category: Endocrinology Source Type: research

Modulating the extension of thyroidectomy in patients with papillary thyroid carcinoma pre-operatively eligible for lobectomy: reliability of ipsilateral central neck dissection
ConclusionsIntraoperative assessment of N status obtained with IpsiCND plus FSE allows for an accurate risk stratification. IpsiCND plus FSE real time modulated thyroidectomy seems a safe and effective surgical strategy reducing the need of a subsequent completion surgery and, theoretically, the risk of local recurrence. (Source: Endocrine)
Source: Endocrine - August 20, 2020 Category: Endocrinology Source Type: research

Apparent mineralocorticoid excess caused by novel compound heterozygous mutations in HSD11B2 and characterized by early-onset hypertension and hypokalemia
ConclusionsWe report novel compound heterozygousHSD11B2 mutations in a Chinese teenager with early-onset hypertension, and enriched genotypic and phenotypic spectrums in AME. Genetic testing helps early diagnosis and treatment for AME patients, which may avoid target organ damage. (Source: Endocrine)
Source: Endocrine - August 20, 2020 Category: Endocrinology Source Type: research

Patients with adrenal insufficiency have cardiovascular features associated with hypovolemia
ConclusionsAI patients on conventional treatment display cardiovascular abnormalities that could be related to hypovolemia. Switch to OD-HC seems to have beneficial effect on blood pressure profile, but no effect on cardiovascular structure and function. (Source: Endocrine)
Source: Endocrine - August 19, 2020 Category: Endocrinology Source Type: research

Characteristics of nephropathy in severely obese Japanese patients complicated with type 2 diabetes mellitus: a cross-sectional cohort study
ConclusionsUrinary occult blood may be a significant independent factor associated with the presence of nephropathy in severely obese Japanese patients with T2DM. The presence of urinary occult blood could thus be an important pathogenic factor in obesity-related nephropathy in patients with T2DM. (Source: Endocrine)
Source: Endocrine - August 17, 2020 Category: Endocrinology Source Type: research

One genotype, many phenotypes: SDHB p.R90X mutation-associated paragangliomas
ConclusionSDHB p.R90X mutation-associated PPGL have significant phenotypic variability and are associated with a high risk of distant metastasis and mortality. (Source: Endocrine)
Source: Endocrine - August 17, 2020 Category: Endocrinology Source Type: research

Identification and analyzes of DUOX2 mutations in two familial congenital hypothyroidism cases
ConclusionsThe present study suggests that the phenotypic features resulting fromDUOX2 mutations vary greatly. The p.R354W and p.S1067L alterations or the combination of the two alterations inDUOX2 are probably only predisposing to CH andDUOX2 may be involved in the morphogenesis of the human thyroid gland. Simultaneously, the compensation of DUOX1 for the loss of DUOX2, undetectable pathogenic mutations, the effects of environmental factors, epigenetic mechanisms and the involvement of multiple genes cannot be excluded in the explanation of these genetic results. (Source: Endocrine)
Source: Endocrine - August 15, 2020 Category: Endocrinology Source Type: research

Status and clinical and radiological predictive factors of presurgical anterior pituitary function in pituitary adenomas. Study of 232 patients
ConclusionMore than one third of PAs candidates for surgery had APD. The male sex, diabetes, an older age, pituitary apoplexy, and larger PAs were risk factors of APD. Hence, in these patients, the hormonal study should be prioritized and the need for dynamic tests must be carefully assessed. (Source: Endocrine)
Source: Endocrine - August 12, 2020 Category: Endocrinology Source Type: research

Impact of short-term hydrocortisone intake on pituitary and adrenal function in healthy young male subjects
ConclusionsOnce-daily oral therapeutic administration of hydrocortisone for 5 days altered adrenal DHEA secretion by inhibiting pituitary ACTH, but this effect seemed transient without significant impairment of basal adrenal or pituitary function 24  h after administration. Given the high correlations between plasma and saliva, saliva samples may be offered as a sensitive surrogate for blood sampling to estimate adrenal and pituitary function. (Source: Endocrine)
Source: Endocrine - August 12, 2020 Category: Endocrinology Source Type: research

Hemodynamic changes in neonates born to mothers with Graves ’ disease
This study prospectively evaluated the hemodynamic changes in neonates born to mothers with GD.MethodsOverall, 80 newborns were enrolled. Thirty-six neonates were born to mothers with GD who were positive for thyroid-stimulating hormone (TSH) receptor antibody (TRAb), and 44 were born to mother negative for TRAb. The serum levels of TSH, free triiodothyronine (FT3), free thyroxine (FT4), and N-terminal-pro-B-type natriuretic peptide (NT-proBNP), the cardiac output, and cardiac index (CI) evaluated by echocardiography were compared between the two groups at several postnatal points (day of delivery and 5, 10, and 30 days of...
Source: Endocrine - August 12, 2020 Category: Endocrinology Source Type: research

Salivary cortisol levels during Ramadan fasting in hydrocortisone-treated secondary adrenal insufficiency patients
ConclusionsSalivary cortisol levels were high in fasting hydrocortisone-treated SAI patients with a disruption of the circadian rhythm. (Source: Endocrine)
Source: Endocrine - August 12, 2020 Category: Endocrinology Source Type: research

Progression and dormancy in metastatic thyroid cancer: concepts and clinical implications
AbstractDistant metastasis classically has been defined as a late-stage event in cancer progression. However, it has become clear that metastases also may occur early in the “lifetime” of a cancer and that they may remain stable at distant sites. This stability of metastatic cancer deposits has been termed “metastatic dormancy” or, as we term it, “metastatic progression dormancy” as the progression either may reflect growth of already existing metastases or new cancer spread. Biologically, dormancy is the presence of nongrowing, static metastatic cells that survive over time. Clinically,...
Source: Endocrine - August 11, 2020 Category: Endocrinology Source Type: research

Hypothesized mechanisms explaining poor prognosis in type 2 diabetes patients with COVID-19: a review
ConclusionsT2D individuals should be considered as more vulnerable to COVID-19 than general population, and thus require adequate advices about hygienic tips to protect themselves during the pandemic. A careful management of glucose levels and diabetes-related comorbidities remains essential for avoiding further complications, and patient monitoring during the pandemic should be performed also at distance by means of telemedicine. Further studies are needed to clarify whether medications normally used for managing T2D and its associated comorbidities could have a protective or detrimental effect on COVID-19 clinical course...
Source: Endocrine - August 10, 2020 Category: Endocrinology Source Type: research

Hyperthermal liquid, spray, and smog may be potential risk factors for recurrent laryngeal nerve thermal injury during thyroid surgeries
AbstractPurposeThe hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments.Methods321 thyroid patients and 32 rats were divided into two groups respectively. A type of endoscopic gauze was implemented in the protected group to prevent nerve from thermal risks. Electromyography and laryngoscope were recorded to determine nerve ’s conductive ability. Microstructural morphological damage to nerves and ...
Source: Endocrine - August 10, 2020 Category: Endocrinology Source Type: research

Personalized management of differentiated thyroid cancer in real life – practical guidance from a multidisciplinary panel of experts
ConclusionsIn routine clinical practice, the Martinique Principles should be implemented in order to optimize clinical management/outcomes of patients with DTC. (Source: Endocrine)
Source: Endocrine - August 9, 2020 Category: Endocrinology Source Type: research

A mutation in NOTCH2 gene first associated with Hajdu –Cheney syndrome in a Greek family: diversity in phenotype and response to treatment
ConclusionsBone involvement can present with diverse severity in the same pedigree, ranging from low BMD to multiple fragility fractures. Antiresorptive therapy improves BMD, but its anti-fracture efficacy remains to be shown. The presence of CD might indicate the significant role of NOTCH2 signaling in different tissues. (Source: Endocrine)
Source: Endocrine - August 9, 2020 Category: Endocrinology Source Type: research

Postoperative vocal fold dysfunction in covid-19 era: are we still in time for a recovery?
(Source: Endocrine)
Source: Endocrine - August 9, 2020 Category: Endocrinology Source Type: research

Cause-specific mortality after diagnosis of thyroid cancer: a large population-based study
ConclusionsWe disclosed distinct mortality patterns by histology and identified predictors of CVD-specific mortality in thyroid cancer survivors, supporting CVD intervention for aggressive thyroid cancer. (Source: Endocrine)
Source: Endocrine - August 8, 2020 Category: Endocrinology Source Type: research

Comparison of postprandial 90th-minute plasma glucose level with 60th- and 120th-minute levels in patients with gestational diabetes: a prospective cohort study
The objective of the present study is to compare postprandial 90th-minute plasma glucose measurement with fasting, postprandial 60 and 120  min in gestational diabetes mellitus (GDM).MethodsOne hundred and thirty-one pregnant women with GDM were hospitalized for regulation of maternal plasma glucose levels. Plasma glucose levels were daily recorded for every patient and treatment option arranged without considering the 90th-minute plasma glucose level. All patients were followed up until birth and pregnancy results were compared.ResultAt the admission, 69% of our patients were on diet and 31% were on insulin with di...
Source: Endocrine - August 7, 2020 Category: Endocrinology Source Type: research

It is time to standardize the TyG index
(Source: Endocrine)
Source: Endocrine - August 7, 2020 Category: Endocrinology Source Type: research