Novel high molecular weight albumin-conjugated angiotensin II activates β-arrestin and G-protein pathways
ConclusionsAddition of a high molecular weight molecule to Ang II reduced its AT1 receptor binding affinity, but did not significantly alter stimulation of aldosterone release or water consumption. The BSA-Ang II conjugate caused a greater saline appetite than Ang II suggesting that it may be a more efficacious agonist of this beta-arrestin-mediated response than Ang II. The higher potency calcium signaling response suggests that the G-protein-coupled responses predominate at physiological concentrations of Ang II, while the beta-arrestin response requires pathophysiological or pharmacological concentrations of Ang II to o...
Source: Endocrine - April 24, 2019 Category: Endocrinology Source Type: research

Response to Letter to the Editor: “ Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas ”
(Source: Endocrine)
Source: Endocrine - April 24, 2019 Category: Endocrinology Source Type: research

Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population
ConclusionsOur results suggest that higher daily life activity and higher moderate-intensity exercise may be independently associated with a lower risk of metabolic syndrome in Japanese adults. (Source: Endocrine)
Source: Endocrine - April 22, 2019 Category: Endocrinology Source Type: research

Is there a correlation between thyroiditis and thyroid cancer?
ConclusionsOur conclusion was that a correlation between thyroiditis and a higher incidence of thyroid cancer is still undefined. (Source: Endocrine)
Source: Endocrine - April 19, 2019 Category: Endocrinology Source Type: research

Detection rate of unknown primary tumour by using somatostatin receptor PET/CT in patients with metastatic neuroendocrine tumours: a meta-analysis
ConclusionsSomatostatin receptor PET/CT is very useful in detecting CUP-NETs in patients with metastatic disease. More studies on the change of management by using this imaging method in this setting are needed. (Source: Endocrine)
Source: Endocrine - April 19, 2019 Category: Endocrinology Source Type: research

Evaluation of cardiovascular risk by growth-differentiation factor-15 and tissue Doppler imaging in children with subclinical hypothyroidism
ConclusionPatients with subclinical hypothyroidism versus healthy individuals had some changes in echocardiographic parameters that indicate involvement of diastolic function of the left ventricle. They were significantly different when compared SH group and the control group. This study demonstrated ventricle diastolic dysfunction in pediatric patients with hypothyroidism. The results of our study suggest that cardiac follow-up may be useful in patients with subclinical hypothyroidism and clinical trials are needed to explore therapeutic effects of T4 and T3 administration in this patients. (Source: Endocrine)
Source: Endocrine - April 19, 2019 Category: Endocrinology Source Type: research

Premature death and risk of cardiovascular disease in young-onset diabetes: a 23-year follow-up of the Da Qing Diabetes Study
This study aimed to investigate premature mortality and the risk of cardiovascular disease (CVD) in Chinese adults with diabetes diagnosed before the age of 45 years.MethodsA total of 519 participants with normal glucose tolerance (NGT) and 630 with newly diagnosed diabetes mellitus (DM) were recruited in 1986 in the Da Qing Diabetes Study. In 2009, the participants were followed up to assess mortality and CVD events. The subjects were stratified into four subgroups according to age and diabetes status: age
Source: Endocrine - April 18, 2019 Category: Endocrinology Source Type: research

Activation profiles of monocyte-macrophages and HDL function in healthy women in relation to menstrual cycle and in polycystic ovary syndrome patients
ConclusionsRegular menstrual cycles entailed fluctuations in macrophage activation. Such dynamic pattern was attenuated in PCOS. Along with impaired HDL function, this may contribute to the increased cardiometabolic risk associated with PCOS. (Source: Endocrine)
Source: Endocrine - April 16, 2019 Category: Endocrinology Source Type: research

Network-based transcriptomic analysis reveals novel melatonin-sensitive genes in cardiovascular system
ConclusionsWe identified numerous melatonin-sensitive genes and further identified five hub genes. The five novel genes are possibly associated with the myocardial benefits of melatonin. (Source: Endocrine)
Source: Endocrine - April 15, 2019 Category: Endocrinology Source Type: research

Upregulated VEGF and Robo4 correlate with the reduction of miR-15a in the development of diabetic retinopathy
ConclusionsVEGF and Robo4 were co-expressed in FVMs from PDR patients. In the early stages of DR, VEGF was upregulated and contributed to DR development, whereas, in the late stage of DR, VEGF and Robo4 worked together to aggravate DR progression. However, miR-15a could downregulate VEGF and Robo4 to ameliorate DR development. (Source: Endocrine)
Source: Endocrine - April 12, 2019 Category: Endocrinology Source Type: research

Adrenocortical carcinoma: presentation and outcome of a contemporary patient series
AbstractBackgroundAdrenocortical carcinoma (ACC) is a rare endocrine carcinoma with poor 5-year survival rates of    20 Hounsfield Units (HU) for all tumours (median 34 (21–45)), median size 92 mm (20–196), Ki67 17% (1–40%), Weiss score 7 (4–9) and Helsinki score 24 (4–48). ACC was more often found in the left than the right adrenal (p   10 years was achieved after repeated surgery of metastases. Overall 5-year survival was 67%, and 96% vs. 26% for ENSAT stage I–II vs. III–IV (p   20 on nonenhanced CT but variable tumour size (20&nda...
Source: Endocrine - April 12, 2019 Category: Endocrinology Source Type: research

The medical treatment with pasireotide in Cushing ’s disease: an Italian multicentre experience based on “real-world evidence”
In conclusion, in the real-life clinical practice, pasireotide treatment nor malizes or nearly normalizes UC in at least 68% of patients with very mild to moderate disease, with consequent improvement in weight, visceral adiposity and lipid profile, despite the occurrence or deterioration of diabetes in the majority of cases, confirming the usefulness of this treatment in pa tients with milder disease and without uncontrolled diabetes. (Source: Endocrine)
Source: Endocrine - April 9, 2019 Category: Endocrinology Source Type: research

The next step after anti-osteoporotic drug discontinuation: an up-to-date review of sequential treatment
The objective of this article is to present up-to-date practical knowledge on this area in order to provide guidance to the clinicians involved in the management of patients with osteoporosis. (Source: Endocrine)
Source: Endocrine - April 8, 2019 Category: Endocrinology Source Type: research

Cellular markers in corticotroph adenomas correlate with hormones –concerns on interpretation
(Source: Endocrine)
Source: Endocrine - April 8, 2019 Category: Endocrinology Source Type: research

A review of the propriety of thyroid ultrasound referrals and their follow-up burden
ConclusionsIn our center, a significant percentage of thyroid US scans along with their subsequent follow-up were potentially avoidable. (Source: Endocrine)
Source: Endocrine - April 6, 2019 Category: Endocrinology Source Type: research

Circulating microRNA-144-3p and miR-762 are novel biomarkers of Graves ’ disease
In this study, we aimed to identify circulating miRNAs as potential biomarkers of GD.MethodsWe recruited 68 participants who met the criteria for GD and healthy controls. The expression profile of miRNAs in plasma was detected using microarrays. We found five interesting miRNAs were differentially expressed between GD and control group and futher validated their relative expression by quantitative real-time PCR. According to their putative target genes predicted by the TargetScan database, we also performed Gene ontology (GO) and Kyoto encyclopedia of genes and genomes (KEGG) analyses to predict their potential functions a...
Source: Endocrine - April 4, 2019 Category: Endocrinology Source Type: research

Biomarkers of response to alpha-lipoic acid  ± palmitoiletanolamide treatment in patients with diabetes and symptoms of peripheral neuropathy
AbstractPurposeTo evaluate the effect of oral alpha-lipoic acid (ALA)  ± palmitoyl-ethanolamide (PEA) on neuropathic symptoms in patients with diabetic peripheral neuropathy (DPN) and to identify factors related to the efficacy of the treatment.MethodsThis is a retrospective observational pilot study evaluating 49 patients with diabetes and positive Neuropathy Symptoms Score (NSS). Clinical and biochemical variables, including NSS, were compared between untreated patients and patients treated with oral 600  mg/day ALA ± 600 mg/day PEA at baseline (first occurrence of ...
Source: Endocrine - April 4, 2019 Category: Endocrinology Source Type: research

Serum IGF-binding protein 2 (IGFBP-2) concentrations change early after gastric bypass bariatric surgery revealing a possible marker of leptin sensitivity in obese subjects
ConclusionsAfter gastric bypass, serum IGFBP-2 increases in a window of time when variations of hormones mediating the effects of bariatric surgery occur. Our results suggest that IGFBP-2, a leptin-regulated protein, may be an in-vivo marker of leptin action. If this is the case, an early improvement of leptin sensitivity might contribute to the anorectic effect of gastric bypass. (Source: Endocrine)
Source: Endocrine - April 3, 2019 Category: Endocrinology Source Type: research

Decreased deiodinase activity after glucose load could lead to atherosclerosis in euthyroid women with polycystic ovary syndrome
AbstractObjectiveGlucose and lipid disturbances, as well as higher tendency to atherosclerosis, are observed in women with polycystic ovary syndrome (PCOS). Thyroid hormones action has long been recognized as an important determinant of glucose and lipid homeostasis. Some studies suggest that even in euthyroid subjects, thyroid function may affect atherosclerosis risk factors. The aim of this study was to evaluate the relationships between thyroid hormonal status and glucose and lipid profile before and after oral glucose tolerance test (OGTT) in PCOS women in comparison to the control group.Patients and methodsThe study g...
Source: Endocrine - April 3, 2019 Category: Endocrinology Source Type: research

Advances in metabolomics of thyroid cancer diagnosis and metabolic regulation
AbstractThyroid cancers (TCs) are the most frequent endocrine malignancy with an unpredictable fast-growing incidence, especially in females all over the world. Fine-needle aspiration biopsy (FNAB) analysis is an accurate diagnostic method for detecting thyroid nodules and classification of TC. Though simplicity, safety, and accuracy of FNAB, 15 –30% of cases are indeterminate, and it is not possible to determine the exact cytology of the specimen. This demands the need for innovative methods capable to find crucial biomarkers with adequate sensitivity for diagnosis and prediction in TC researches. Cancer-based metab...
Source: Endocrine - April 1, 2019 Category: Endocrinology Source Type: research

Thyroid metastasis from breast cancer detected by 18F-FDG PET/CT
(Source: Endocrine)
Source: Endocrine - April 1, 2019 Category: Endocrinology Source Type: research

miR-650 promotes motility of anaplastic thyroid cancer cells by targeting PPP2CA
ConclusionsmiR-650 displayed oncogenic activity in ATC cells through targeting PPP2CA phosphatase. These results suggest that miR-650/PPP2CA axis could be modulated to interfere with motile ability of thyroid carcinoma cells. (Source: Endocrine)
Source: Endocrine - March 29, 2019 Category: Endocrinology Source Type: research

Is TSH suppression still necessary in intermediate- and high-risk papillary thyroid cancer patients with pre-ablation stimulated thyroglobulin & lt;1  ng/mL before the first disease assessment?
AbstractObjectiveSince papillary thyroid cancer (PTC) patients with pre-ablation stimulated thyroglobulin (s-Tg)  
Source: Endocrine - March 28, 2019 Category: Endocrinology Source Type: research

Body fat indices as effective predictors of insulin resistance in obese/non-obese polycystic ovary syndrome women in the Southwest of China
This study is aimed to predict IR in Chinese women with PCOS of different body types based on body fat indices.MethodsA total of 723 women diagnosed with PCOS according to Rotterdam criteria were recruited in this study and were further divided into two groups based on their BMI. All participants underwent physical examinations and ultrasound; and blood was collected from them on the days 3 –5 of the menstrual cycle. Their BMI, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), lipid accumulation product (LAP) index, visceral adiposity index (VAI), and the homeostasis model assessment index of insulin resistance...
Source: Endocrine - March 28, 2019 Category: Endocrinology Source Type: research

Association between vitamin D receptor gene polymorphisms and Graves ’ disease: a systematic review and meta-analysis
ConclusionsThe TT subtype of the TaqI polymorphism was associated with a higher susceptibility for GD compared with Tt and tt. Regarding BsmI, the bb subtype was associated with increased GD risk in Caucasians, whereas it is protective in Asians. (Source: Endocrine)
Source: Endocrine - March 28, 2019 Category: Endocrinology Source Type: research

High-intensity focused ultrasound (HIFU) for benign thyroid nodules: 2-year follow-up results
AbstractBackgroundHigh-intensity focused ultrasound (HIFU) is the last introduced thermal treatment of thyroid nodules. Here we evaluated the results at 24 months after HIFU.MethodsSince 2016, HIFU was considered as a therapeutic option at our institute in patients with benign thyroid nodules presenting local symptoms. We searched in our database all patients who had undergone thyroid HIFU and selected for the study only cases followed-up for at least 24 months after the treatment. Volume reduction rate (VRR) was evaluated. A reduction above 50% defined the success of HIFU.ResultsThirty-one nodules of 31 patients (24 femal...
Source: Endocrine - March 28, 2019 Category: Endocrinology Source Type: research

Enhanced hepatic cholesterol accumulation induced by maternal betaine exposure is associated with hypermethylation of CYP7A1 gene promoter
AbstractPurposeBetaine contains three methyl groups and plays a critical role in regulating glucose and lipid metabolism via epigenetic modifications. However, it is unclear whether prenatal betaine intake could affect cholesterol metabolism of progeny through DNA methylation.MethodsHence, pregnant rats were randomly divided into control and betaine groups fed standard diet or 1% betaine supplementation diet, respectively, throughout gestation and lactation.ResultsMaternal betaine exposure significantly (P 
Source: Endocrine - March 28, 2019 Category: Endocrinology Source Type: research

In thyroxine-replaced hypothyroid postmenopausal women under simultaneous calcium supplementation, switch to oral liquid or softgel capsule l -thyroxine ensures lower serum TSH levels and favorable effects on blood pressure, total cholesterolemia and glycemia
AbstractPurposeIn postmenopausal women under L-T4 therapy, which was subsequently accompanied by calcium carbonate (CC) supplementation taken 6 –8 h after tablet L-T4, TSH levels were greater than prior to adding CC. Total cholesterolemia [CHOL], fasting glycemia [FG], systolic and diastolic blood pressure [SBP, DBP] were also greater than baseline. Our aim was to explore the effects of either liquid or softgel capsule L-T4, while maint aining CC ingestion 6–8 h, later on TSH levels, CHOL, FG, SBP, and DBP.MethodsWe proposed to 50 hypothyroid postmenopausal women under tablet L-T4 therapy, to swit...
Source: Endocrine - March 27, 2019 Category: Endocrinology Source Type: research

Incidental diagnosis of very small rectal neuroendocrine neoplasms: when should endoscopic submucosal dissection be performed? A single ENETS centre experience
ConclusionsWhen the r-NEN polyp was larger than 3  mm, ESD was indicated. Unlike the size of the tumour, grading and EUS features did not accurately predict residual disease. (Source: Endocrine)
Source: Endocrine - March 27, 2019 Category: Endocrinology Source Type: research

Relationship between metabolic syndrome and thyroid nodules and thyroid volume in an adult population
In this study, we aimed to assess the relationships between MetS and TN and TV in an adult population.MethodsThis cross-sectional study was performed in an adult population in Tianjin. A total of 2606 subjects were enrolled. TV and TN were measured by thyroid ultrasonography. Blood samples were collected to measure biochemical and metabolic parameters.ResultsThe prevalence of TN was significantly higher in the MetS (+) group than in the MetS ( −) group (P 
Source: Endocrine - March 27, 2019 Category: Endocrinology Source Type: research

A novel mutation in INS gene linked to permanent neonatal diabetes mellitus
ConclusionsThis case could help us understand the role of theINS mutation in the development of diabetes. (Source: Endocrine)
Source: Endocrine - March 26, 2019 Category: Endocrinology Source Type: research

The effectiveness of metformin, oral contraceptives, and lifestyle modification in improving the metabolism of overweight women with polycystic ovary syndrome: a network meta-analysis
ConclusionsFor overweight polycystic ovary syndrome patients, our evidence revealed that EE/CA and EE/SRSP combined with metformin or lifestyle changes can reduce the adverse effects on glucose and lipid metabolism of the use of oral contraceptive agents alone. Conventional PCOS treatments, such as metformin, EE/CA, and EE/DRSP, combined with lifestyle control can be particularly effective in improving the homeostasis model assessment of insulin resistance and lipid metabolism. (Source: Endocrine)
Source: Endocrine - March 25, 2019 Category: Endocrinology Source Type: research

Hyperthyroidism influences renal function
AbstractPurposeWhile the effects of hypothyroidism on renal function have been studied extensively, there is less information concerning the effect of hyperthyroidism. We aimed to elucidate the effect of overt and subclinical hyperthyroidism, on estimated glomerular filtration rate (eGFR) with large number of patients treated for hyperthyroidism and after euthyroidism was achieved.MethodA total of 433 consecutive overt and subclinical hyperthyroid patients were included in the study. We assessed serum fT3, fT4, TSH, BUN, creatinine, and eGFR measurements during both hyperthyroid and euthyroid states of the same patients. T...
Source: Endocrine - March 23, 2019 Category: Endocrinology Source Type: research

Liraglutide modulates adipokine expression during adipogenesis, ameliorating obesity, and polycystic ovary syndrome in mice
ConclusionThis study suggests that adiponectin may act as a link between metabolic disorders and PCOS and that liraglutide might be a promising therapeutic agent for the treatment of PCOS in addition to obesity and insulin resistance. (Source: Endocrine)
Source: Endocrine - March 23, 2019 Category: Endocrinology Source Type: research

Comparison of stress response following microwave ablation and surgical resection of benign thyroid nodules
AbstractPurposeTo compare the effects and safety of using microwave ablation (MWA) and surgical resection for the treatment of benign thyroid nodules (BTNs) under ultrasonic guidance and investigate the effects of this treatment on stress response.MethodsPatients with BTNs were divided into the MWA and operation groups (72 cases each). Interleukin (IL)-6, IL-8, serum tumor necrosis factor (TNF- α), and hydrostatic visual analog scale (VAS) prior to the operation, at 6 h, 24 h, and 72 h post-operation were compared between the two groups. Operation times, hospitalization times, hospitalization exp...
Source: Endocrine - March 23, 2019 Category: Endocrinology Source Type: research

Clinical practice guidelines on ultrasound-guided fine needle aspiration biopsy of thyroid nodules: a critical appraisal using AGREE II
ConclusionsOverall, the quality of guidelines on FNAB of thyroid nodules is satisfactory when evaluated using the AGREE II instrument. (Source: Endocrine)
Source: Endocrine - March 22, 2019 Category: Endocrinology Source Type: research

Healthcare utilization and costs among patients with non-functioning pituitary adenomas
ConclusionHealthcare usage and costs among patients treated for an NFPA are substantial and were associated with self-perceived health status, disease bother, and healthcare needs rather than endocrine status, treatment, or duration of follow-up. These findings suggest that targeted interventions addressing disease bother and unmet needs in the chronic phase are needed. (Source: Endocrine)
Source: Endocrine - March 22, 2019 Category: Endocrinology Source Type: research

Relationship among obesity, insulin resistance, and hyperinsulinemia in the polycystic ovary syndrome
AbstractPurposeTo evaluate the relationship between obesity and insulin resistance among women with polycystic ovary syndrome (PCOS) using a gold standard test.MethodsA retrospective database analysis of 75 women with PCOS and 118 normal controls who underwent a modification of the insulin suppression test. The relationships between body mass index (BMI) and steady-state plasma glucose (SSPG) levels were investigated.ResultsMean SSPG score for PCOS subjects was statistically similar than that of the controls at all BMI groupings. Only when PCOS subjects reached a BMI of ≥30 kg/m2 that the PCOS subjects had higher...
Source: Endocrine - March 21, 2019 Category: Endocrinology Source Type: research

Hyperprolactinemia is associated with a high prevalence of serum autoantibodies, high levels of inflammatory cytokines and an abnormal distribution of peripheral B-cell subsets
AbstractPurposeHyperprolactinemia (HPRL) has been reported in many autoimmune diseases. However, the serum autoantibody profile and peripheral B-cell subset distribution in women with HPRL are largely unknown. The current study aimed to investigate the autoantibody prevalence and cytokine levels as well as to further explore the B-cell subset distribution in women with HPRL.MethodsSera from 202 women with HPRL and 97 healthy women were included in this study. All sera were examined for prolactin (PRL), anti-nuclear antibody (ANA), rheumatoid factor, anticardiolipin (ACL), immunoglobulin G, immunoglobulin M, complement 3, c...
Source: Endocrine - March 18, 2019 Category: Endocrinology Source Type: research

Baseline levels determine magnitude of increment in 25 hydroxy vitamin D following vitamin D3 prescription in healthy subjects
AbstractIntroductionVitamin D deficiency is a major health problem which affects about one billion people in the world. Although, vitamin D supplementation is recommended as standard treatment of vitamin D deficiency, there are controversies on dose response relationship. In this regard, the present study aimed to determine the impact of vitamin D3 supplement on raising of serum 25 hydroxyvitamin D[25(OH)D] in healthy subjects with varying degrees of vitamin D deficiency.Materials and methodsIn this clinical trial 114 subjects with varying degrees of vitamin D deficiency were entered and divided into three groups: serum le...
Source: Endocrine - March 14, 2019 Category: Endocrinology Source Type: research

Therapeutic sequences in patients with grade 1 −2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group
ConclusionsSSA followed by SSA high dose, everolimus, chemotherapy or PRRT represent the main therapeutic sequences in G1 −G2 NET. Median PFS was not significantly different between sequences. However, the sequences with SSA high dose or PRRT seem to be better tolerated than sequences with everolimus or chemotherapy. (Source: Endocrine)
Source: Endocrine - March 14, 2019 Category: Endocrinology Source Type: research

Novel PET tracers: added value for endocrine disorders
SummaryNuclear medicine has been implicated in the diagnosis and treatment of endocrine disorders for several decades. With recent development of PET tracers, functional imaging now plays a major role in endocrine tumors enabling with high performance to their localization, characterization, and staging. Besides18F-FDG, which may be used in the management and follow-up of endocrine tumors, new tracers have emerged, such as18F-DOPA for neuroendocrine tumors (NETs) (medullary thyroid carcinoma, pheochromocytomas and paragangliomas and well-differentiated NETs originating from the midgut) and18F-Choline in the field of primar...
Source: Endocrine - March 14, 2019 Category: Endocrinology Source Type: research

Recombinant human thyrotropin (rhTSH) versus Levo-thyroxine withdrawal in radioiodine therapy of differentiated thyroid cancer patients: differences in abdominal absorbed dose
ConclusionsDTC patients treated with 131-radioiodine after rhTSH stimulation have lower abdominal radioiodine activity than hypothyroid patients. Our data could be of practical relevance in terms of patient management. The potential impact on rare radioiodine-related gastrointestinal side effects is to be established in specifically designed prospective studies. (Source: Endocrine)
Source: Endocrine - March 14, 2019 Category: Endocrinology Source Type: research

Levothyroxine absorption test results in patients with TSH elevation resistant to treatment
ConclusionIn cases where TSH normalization is not achieved despite high doses of LT4 therapy, LT4 absorption test is an easy test for administration and interpretation and prevents unnecessary medical treatments and examinations. (Source: Endocrine)
Source: Endocrine - March 13, 2019 Category: Endocrinology Source Type: research

Prognostic impact of visit-to-visit glycemic variability on the risks of major adverse cardiovascular outcomes and hypoglycemia in patients with different glycemic control and type 2 diabetes
AbstractPurposeThe prognostic impact of visit-to-visit glycemic variability on clinical outcomes in patients with different glycemic control and type 2 diabetes remains obscure. We investigated glucose variability and clinical outcomes for patients in the groups of Good glycemic control (GC), Insufficient glycemic control (IC), and Poor glycemic control (PC) in a prospective cohort study.MethodsBy using data from Action in Diabetes and Vascular disease: preterAx and diamicroN-MR Controlled Evaluation (ADVANCE), 930 patients were enrolled from 61 centers in China and grouped into GC, IC, and PC according to their glycated h...
Source: Endocrine - March 13, 2019 Category: Endocrinology Source Type: research

Non-invasive follicular thyroid neoplasm with papillary-like nuclearfeatures (NIFTP): a review and update
ConclusionNIFTP carries an excellent prognosis. It is critical for both clinicians and patients to be aware of extremely indolent behavior of NIFTP in order to prevent unnecessary, aggressive treatment. (Source: Endocrine)
Source: Endocrine - March 13, 2019 Category: Endocrinology Source Type: research

Weight change is associated with increased all-cause mortality and non-cardiac mortality among patients with type 2 diabetes mellitus
ConclusionsWeight was stable in most T2DM patients with high risk of CVD. Weight loss and gain is associated with increased all-cause mortality and non-cardiac mortality. Pronounced weight loss and weight gain is associated with a slight increase in cardiac death and non-fatal MI incidence, which does not reach statistical significance. (Source: Endocrine)
Source: Endocrine - March 12, 2019 Category: Endocrinology Source Type: research

BRAF V600E -mutant cancers display a variety of networks by SWIM analysis: prediction of vemurafenib clinical response
ConclusionsWe are persuaded that our network analysis may aid in the comprehension of molecular mechanisms underlying the different responses to vemurafenib inBRAFV600E mutant tumours. (Source: Endocrine)
Source: Endocrine - March 8, 2019 Category: Endocrinology Source Type: research

Autonomous cortisol secretion in adrenal incidentalomas
AbstractAdrenal incidentalomas (AI) are one of the most frequent reasons for consultation in Endocrinology, as they are present in 3 –10% of the general population. Up to 20% of them may have autonomous cortisol secretion (ACS), a term that refers to AI carriers with biochemical evidence of excess cortisol, but without the “specific” clinical signs of Cushing’s syndrome. As ACS is associated with an increased risk of diab etes, obesity, high blood pressure (HBP), osteoporosis, cardiovascular events, and global mortality; its correct identification is of great importance. There are different laborato...
Source: Endocrine - March 7, 2019 Category: Endocrinology Source Type: research

Can baseline endocrinological examination and thyroid ultrasound predict the development of thyroid disease in immunotherapy-treated patients? Results from a prospective, single-center, open-label study
AbstractPurposeImmune-checkpoint inhibitors have shown great efficacy in clinical oncology and a very safe toxicity profile. Nevertheless, endocrine toxicity and, in particular, thyroid diseases are among the most frequently reported adverse events. The aim of this study was to assess the utility of a complete endocrine evaluation before starting therapy, in order to predict which patients will develop a thyroid disease and will need a close follow-up.MethodsTwenty-eight patients were treated with ipilimumab and nivolumab for non-small-cell lung cancer or malignant pleural mesothelioma. All patients underwent complete endo...
Source: Endocrine - March 6, 2019 Category: Endocrinology Source Type: research