Liraglutide induces beige fat development and promotes mitochondrial function in diet induced obesity mice partially through AMPK-SIRT-1-PGC1- α cell signaling pathway
Conclusionsthe anti-obesity effect of liraglutide occurs through adaptive thermogenesis and may act through different cell signaling pathways in fat and skeletal muscle tissue. Liraglutide induces beige fat development partially through the AMPK-SIRT-1-PGC1- α cell signaling pathway. Therefore, liraglutide is a potential medication for obesity prevention and in targeting pre-diabetics. (Source: Endocrine)
Source: Endocrine - December 9, 2018 Category: Endocrinology Source Type: research

Adrenal myelolipoma in association with congenital adrenal hyperplasia
(Source: Endocrine)
Source: Endocrine - December 8, 2018 Category: Endocrinology Source Type: research

Italian consensus for the classification and reporting of thyroid cytology: the risk of malignancy between indeterminate lesions at low or high risk. A systematic review and meta-analysis
ConclusionsThe Italian system for thyroid cytology is reliable to assess indeterminate lesions at low and high risk, being Tir 3B associated with a cancer risk significantly higher than Tir 3A, also when considering NIFTP as non-malignant entity. (Source: Endocrine)
Source: Endocrine - December 5, 2018 Category: Endocrinology Source Type: research

Use of antiosteoporotic drugs and calcium/vitamin D in patients with fragility fractures: impact on re-fracture and mortality risk
AbstractPurposeTo evaluate the impact of pharmacological treatment in osteoporosis patients with recent fracture and to assess the incidence of subsequent fracture and all-cause mortality.MethodsThis observational retrospective study was based on data from administrative databases of five Italian Local Health Units. Osteoporosis patients aged  ≥ 50 years with hospitalization for vertebral or hip fracture occurring between 01/01/2011 and 31/12/2015 were included. Treatment adherence was calculated using the medication possession ratio. Multivariable proportional hazard Cox model was used to identify factors...
Source: Endocrine - December 4, 2018 Category: Endocrinology Source Type: research

Glycemic variation in uncontrolled Graves ’ disease patients with normal glucose metabolism: Assessment by continuous glucose monitoring
AbstractPurposeTo observe the glycemic variation (GV) in uncontrolled Graves ’ disease (GD) patients with normal glucose metabolism measured by continuous glucose monitoring (CGM).MethodsThis was a single-center, open-label, observational study. From January 2017 to October 2017, 20 GD patients with normal glucose metabolism and 24 healthy control subjects were recruited. Serum samples were obtained at 0, 30, and 120  min after oral glucose loading for glucose, insulin, and C-peptide level measurements. Fasting plasma fasting free triiodothyronine (FT3), free thyroxin (FT4), and thyroid stimulating hormone con...
Source: Endocrine - December 4, 2018 Category: Endocrinology Source Type: research

Therapy of moderate-to-severe Graves ’ orbitopathy with intravenous methylprednisolone pulses is not associated with loss of bone mineral density
ConclusionsIVMP given in weekly intravenous pulses does not lead to loss of BMD of the lumbar spine and the femoral neck. (Source: Endocrine)
Source: Endocrine - December 1, 2018 Category: Endocrinology Source Type: research

Correction to: Anti-M üllerian hormone serum levels in systemic lupus erythematosus patients: influence of the disease severity and therapy on the ovarian reserve
The original version of this article unfortunately contained a mistake in given and family names of all the authors. (Source: Endocrine)
Source: Endocrine - December 1, 2018 Category: Endocrinology Source Type: research

Complement C3 and C4, but not their regulators or activated products, are associated with incident metabolic syndrome: the CODAM study
ConclusionsIn the cross-sectional analyses, the effects sizes (standardized regression coefficients) for C3 and C4 were similar to those of (some of) the regulators and activators, yet only C3 and C4 were associated with incident disease. These findings suggest a role for C3 and C4, but not their regulators or activated products, in the development of the metabolic syndrome. (Source: Endocrine)
Source: Endocrine - November 17, 2018 Category: Endocrinology Source Type: research

Assessing the clinical and molecular diagnosis of inherited forms of impaired sensitivity to thyroid hormone from a single tertiary center
ConclusionIn the present series, most cases were RTH β with higher levels of TSH. We described three novel mutations inTHRB (p.M313V, p.R320G and p.R438P) and the first patients with FDH molecular diagnosis (p.R242H) documented in Brazil. (Source: Endocrine)
Source: Endocrine - November 17, 2018 Category: Endocrinology Source Type: research

Fabula (non) acta est ….Endocrine
(Source: Endocrine)
Source: Endocrine - November 17, 2018 Category: Endocrinology Source Type: research

Tumoral MGMT content predicts survival in patients with aggressive pituitary tumors and pituitary carcinomas given treatment with temozolomide
(Source: Endocrine)
Source: Endocrine - November 17, 2018 Category: Endocrinology Source Type: research

30mCi radioactive iodine achieving comparative excellent response in intermediate/high-risk nonmetastatic papillary thyroid cancer: a propensity score matching study
AbstractObjectiveTo determine the efficacy of low-dose radioactive iodine (RAI) therapy (30  mCi, 1110 MBq) in Chinese patients with intermediate- to high-risk papillary thyroid cancer (PTC) without distant metastasis.Design and methodsThis large retrospective study included Chinese patients with PTC that tested negative for thyroglobulin antibodies. Patients were categorized into low-dose (30  mCi, 1110 MBq) and high-dose (>100  mCi, 3700 MBq) RAI groups. Ablation rate and long-term response were compared between groups using propensity score matching (PSM) to minimize bias and confou...
Source: Endocrine - November 17, 2018 Category: Endocrinology Source Type: research

The effects of metformin on simple obesity: a meta-analysis
AbstractObjectiveTo evaluate the efficacy of metformin versus a placebo in the treatment of patients with simple obesity without obesity related diseases.MethodsA search was done on Pub-Med, EMBASE, Cochrane, and Science Citation Index Expanded databases. The main inclusion criteria included the following:(1) randomized controlled trials. (2) patients diagnosed as being overweight or obese. (3) patients were randomly assigned to receive metformin or control. Exclusion criteria included the following: patients diagnosed with an obesity related disease, such as diabetes mellitus (DM) or polycystic ovary syndrome (PCOS).Resul...
Source: Endocrine - November 17, 2018 Category: Endocrinology Source Type: research

Does quality of life differ in patients with Addison ’s disease on different glucocorticoid therapies?
(Source: Endocrine)
Source: Endocrine - November 17, 2018 Category: Endocrinology Source Type: research

Larger ascending aorta in primary aldosteronism: a 3-year prospective evaluation of adrenalectomy vs. medical treatment
AbstractObjectivePrimary aldosteronism is associated with higher cardiovascular morbidity as compared with essential hypertension. Vascular complications encompass myocardial infarction and cerebrovascular events. Aortic damage in primary aldosteronism has never been explored, although a few cases of ascending aorta aneurisms have been reported.Design and methodsWe consecutively enrolled patients affected by primary aldosteronism (n = 45) and compared them with patients affected by essential hypertension (n = 47), on an outpatient setting. Echocardiographic data of patients with primary aldoster...
Source: Endocrine - November 14, 2018 Category: Endocrinology Source Type: research

Overexpression of CAV3 facilitates bone formation via the Wnt signaling pathway in osteoporotic rats
ConclusionOverexpressed CAV3 promotes bone formation and suppresses the osteoporosis progression via the activation of the Wnt signaling in rat models, suggesting CAV3 as a potential target biomarker in the treatment of osteoporosis. (Source: Endocrine)
Source: Endocrine - November 14, 2018 Category: Endocrinology Source Type: research

Quality of life assessment in patients with HNF1A-MODY and GCK-MODY
AbstractAimThe impact of maturity onset diabetes of the young (MODY) on quality of life (QoL) has never been examined. We assessed disease impact on QoL among patients with HNF1A-MODY andGCK mutation carrier status.MethodsThe study included 80 patients with HNF1A-MODY and 89GCK gene mutation carriers. We also examined 128 type 1 diabetes (T1DM) patients for comparison. Diabetes-specific QoL was assessed using the Audit of Diabetes Dependent Quality of Life questionnaire.ResultsHNF1A-MODY and GCK-MODY groups had similar mean age (41.7 vs. 38.0 years, respectively) and BMI (24.1 vs. 24.3  kg/m2), whereas T1DM patients...
Source: Endocrine - November 12, 2018 Category: Endocrinology Source Type: research

Microbiome and its relation to gestational diabetes
ConclusionsOur findings suggest that changes in the composition of the vaginal and intestinal microbiome might be involved in the development of GDM. The follow-up of these patients in order to evaluate vaginal and intestinal samples after delivery may contribute to understanding the development of metabolic disease in women with previous GDM. (Source: Endocrine)
Source: Endocrine - November 12, 2018 Category: Endocrinology Source Type: research

Letter to the Editor: SNAS and thyroid autoimmunity risk
(Source: Endocrine)
Source: Endocrine - November 12, 2018 Category: Endocrinology Source Type: research

Is GH nadir during OGTT a reliable test for diagnosis of acromegaly in patients with abnormal glucose metabolism?
In this study, we compared the GH nadir during OGTT in patients evaluated for acromegaly in the presence and absence of AGM.MethodsThis is a retrospective cohort study of patients with acromegaly (G1,n = 40) and a group in whom acromegaly was not confirmed (G2,n = 53) who had OGTT-GH suppression test during 2000–2012, using a monoclonal GH immunoenzymatic assay. The patients were categorized as having normal glucose metabolism (NGM) or AGM. GH nadir during OGTT in each group were compared.ResultsIn G1 and G2, 17 and 19 patients had AGM, respectively. Among 17 patients with diabetes, median...
Source: Endocrine - November 10, 2018 Category: Endocrinology Source Type: research

Long-term control of Paget ’s disease of bone with low-dose, once-weekly, oral bisphosphonate preparations, in a “real world” setting
ConclusionIn a large proportion of “real world” PDB patients, remission can be achieved with once-weekly, “osteoporosis doses” of alendronate or risedronate. (Source: Endocrine)
Source: Endocrine - November 8, 2018 Category: Endocrinology Source Type: research

Effects of exenatide and liraglutide on postchallenge glucose disposal in individuals with normal glucose tolerance
ConclusionsOur results suggest that exenatide decelerates the increase in plasma glucose levels through inhibition of glucose absorption and that it exerts an insulin-sparing action after glucose challenge. (Source: Endocrine)
Source: Endocrine - November 8, 2018 Category: Endocrinology Source Type: research

High frequency deep transcranial magnetic stimulation acutely increases β-endorphins in obese humans
ConclusionsA single session of HF dTMS treatment determines in obese subjects an acute increase of β-endorphin level, indicating an activation of the reward pathway. The present findings constitute proof of principle for a potential application of this methodology in obesity treatment. (Source: Endocrine)
Source: Endocrine - November 8, 2018 Category: Endocrinology Source Type: research

Acknowledgment of Reviewers 2016 and 2017
(Source: Endocrine)
Source: Endocrine - November 8, 2018 Category: Endocrinology Source Type: research

Assessing the predictive accuracy of oral glucose effectiveness index using a calibration model
In this study, we used a calibration model analysis to evaluate the accuracy of surrogate indices to predict GE from the reference FSIVGTT (SgMM).MethodsSubjects (n = 123, mean age 48 ± 11 years; BMI 35.9 ± 7.3 kg/m2) with varying glucose tolerance (NGT,n = 37; IFG/IGT,n = 78; and T2DM,n = 8) underwent FSIVGTT and OGTT on two separate days. Predictive accuracy was assessed by both root mean squared error (RMSE) of prediction and leave-one-out cross-validation-type RMSE of prediction (CVPE).ResultsAs expected, insulin se...
Source: Endocrine - November 6, 2018 Category: Endocrinology Source Type: research

Changes in metabolic parameters and cardiovascular risk factors after therapeutic control of acromegaly vary with the treatment modality. Data from the Bic être cohort, and review of the literature
ConclusionTreatments used to normalize IGF-I levels in patients with acromegaly could have differential effects on cardiovascular risk factors and metabolic parameters. (Source: Endocrine)
Source: Endocrine - November 5, 2018 Category: Endocrinology Source Type: research

Limited short-term effects on human prostate cancer xenograft growth and epidermal growth factor receptor gene expression by the ghrelin receptor antagonist [D-Lys 3 ]-GHRP-6
ConclusionsWe show that [D-Lys3]-GHRP-6 has transitory effects on prostate xenograft tumours in mice, which rapidly develop an apparent resistance to the antagonist. Although further studies on [D-Lys3]-GHRP-6 are warranted, we suggest that daily treatment with the antagonist is not a suitable treatment for advanced prostate cancer. (Source: Endocrine)
Source: Endocrine - November 2, 2018 Category: Endocrinology Source Type: research

Determination of effective half-life of 131 I in patients with differentiated thyroid carcinoma: comparison of cystatin C and creatinine-based estimation of renal function
ConclusionseGFRCysC should be included in further study protocols. As camera and probe measurements lead to almost superimposable results, one of the methods is expendable. Blood-based results oft1/2,eff were lower, presumably due to unspecific iodine retention, whereas the lower correlation with renal function may be caused by individual differences in intestinal iodine resorption. SP-protocols up to 42  h after I-131 administration are sufficient to determinet1/2,eff. Further studies are necessary for specific recommendations regarding I-131 activity reduction during RAIT in patients with DTC and renal insufficien...
Source: Endocrine - November 1, 2018 Category: Endocrinology Source Type: research

Melatonin treatment suppresses appetite genes and improves adipose tissue plasticity in diet-induced obese zebrafish
ConclusionsIt seems that adequate melatonin treatment exerts anti-obesity protective effects, also in a diet-induced obesity zebrafish model, that might be the result of the restoration of many factors: the final endpoint reached is weight loss and stabilization of weight gain. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

New modified Friedewald formulae for estimating low-density lipoprotein cholesterol according to triglyceride levels: extraction and validation
This study aims to extract and validate new modified Friedewald formulae for estimating LDLC according to triglyceride (TG) levels in Iranians.MethodsTotal cholesterol (TC), high-density lipoprotein cholesterol (HDLC), LDLC, and TG were measured in 5030 fasted subjects. The original FF was used for estimating LDLC. Data were divided into training and validation data sets. For extracting modified Friedewald formulae, linear regression was used with TG as independent and TC, HDLC, and directly measured LDLC (D-LDLC) as dependent variables, respectively. An overall modified formula was extracted for TG concentrations
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Cabergoline for the treatment of bromocriptine-resistant invasive giant prolactinomas
ConclusionsData of this retrospective study demonstrate that cabergoline is an excellent option for the treatment of patients with bromocriptine-resistant IGPs. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Temporal relationship of sleep apnea and acromegaly: a nationwide study
ConclusionSleep apnea is common among patients with acromegaly, and is often diagnosed prior to their acromegaly diagnosis. These results support early screening for sleep apnea in patients with acromegaly and awareness for acromegaly in patients with sleep apnea. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Strategies to reduce readmissions for hyponatremia after transsphenoidal surgery for pituitary adenomas
ConclusionsMild fluid restriction (to 1.5 liters daily), in addition to a single post-operative serum sodium level, is an effective approach to preventing readmission for hyponatremia after TSS for pituitary adenomas. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Insights on the phenotypic heterogenity of 11 β-hydroxylase deficiency: clinical and genetic studies in two novel families
ConclusionCYP11B1 mutations were associated with highly variable phenotypes, from mild to severe virilization, and early-onset hypertension or salt wasting. Further analysis of variants in other hypertension-related genes, steroid synthesis and metabolism compensatory pathways, and/or the investigation of chimericCYP11B genes are needed to clarify the phenotypic heterogeneity in 11 β-hydroxylase deficiency. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Brown Adipose Tissue (BAT) detection by 18 F-FDG PET and thyroid hormone level(s) —a systematic review
(Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Effect of timing of levothyroxine administration on the treatment of hypothyroidism: a three-period crossover randomized study
ConclusionThe three investigated timing regimens of LT4 administration were equally efficient and offer additional options regarding the treatment individualization. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

A novel nonsense EIF1AX mutation identified in a thyroid nodule histologically diagnosed as oncocytic carcinoma
(Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Efficacy and safety of long-acting pasireotide in patients with somatostatin-resistant acromegaly: a multicenter study
ConclusionsIn the real-life scenario ~54% of patients with acromegaly resistant to first-generation SSA, may normalize IGF-1 with pasireotide; however, 63% experienced glucose control deterioration. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

The association of smoking and risk of diabetic retinopathy in patients with type 1 and type 2 diabetes: a meta-analysis
AbstractPurposeTo clarify the relevance between smoking and diabetic retinopathy in patients with type 1 and type 2 diabetes mellitus.MethodsPublished evidence were searched in MEDLINE and EMBASE from the databases began until Feb. 2017. Studies evaluating the association between smoking and diabetic retinopathy or evaluating the risk factors of diabetic retinopathy including smoking were included.ResultsTotally 73 studies were identified, among which 19 studies included type 1 diabetes patients and 56 studies included type 2 diabetes patients. In type 1 diabetes, compare with non-smokers, the risk of diabetic retinopathy ...
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Primary hyperparathyroidism in prostate cancer: guilty or not guilty?
(Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis
ConclusionsPCOS is associated with an increased risk of diagnosis of depression, anxiety, bipolar disorder, and obsessive compulsive disorder. It is associated with worse symptoms of depression, anxiety, OCD, and somatization. Screening for these disorders to allow early intervention may be warranted. (Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Predictors of surgical outcome and early criteria of remission in acromegaly —some controversial issues
(Source: Endocrine)
Source: Endocrine - October 15, 2018 Category: Endocrinology Source Type: research

Clinical characteristics and surgical outcome in USP8 -mutated human adrenocorticotropic hormone-secreting pituitary adenomas
AbstractPurposesomatic mutations in the ubiquitin-specific protease 8 (USP8) gene have recently been described in patients with Cushing ’s disease (CD). The aim of the study is to verify whetherUSP8 mutation may predict early and late outcome of pituitary surgery in patients with CD operated at a single institution.MethodsWe performed a retrospective genetic analysis of 92 adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Specimens were screened forUSP8 hotspot mutations in the exon 14 with Sanger sequencing. Hormonal and surgical data were compared betweenUSP8 variant carriers and wild-type tumors.Res...
Source: Endocrine - October 12, 2018 Category: Endocrinology Source Type: research

Effects of dehydroepiandrosterone (DHEA) supplementation on sexual function in premenopausal infertile women
AbstractPurposeTo investigate the effects of dehydroepiandrosterone (DHEA) supplementation on female sexual function in premenopausal infertile women of advanced ages.MethodsThis observational study was conducted in an academically affiliated private fertility center. Patients included 87 premenopausal infertile women, 50 of whom completed the study including the Female Sexual Function Index (FSFI) questionnaires and comprehensive endocrine evaluation before and 4 –8 weeks after initiating 25 mg of oral micronized DHEA TID.ResultsAge of patients was 41.1  ± 4.2 years, BMI 24.4 &plus...
Source: Endocrine - October 11, 2018 Category: Endocrinology Source Type: research

The effects of sampling lateralization on bilateral inferior petrosal sinus sampling and desmopressin stimulation test for pediatric Cushing's disease
ConclusionsThe sensitivity of BIPSS in pediatric CD was low at baseline, but increased after desmopressin stimulation. Sampling lateralization cannot accurately indicate the tumor lateralization, but the absence of sampling lateralization with low ACTH at IPS is a hint of false-negative cases in BIPSS. (Source: Endocrine)
Source: Endocrine - October 11, 2018 Category: Endocrinology Source Type: research

Is calcitonin gene-related peptide a modulator of menopausal vasomotor symptoms?
ConclusionsThe duration of the perception of each hot flush in a woman is brief, while local reddening after intradermal administration of α-CGRP persists for 1 to 6 h. This contrast remains unclear. (Source: Endocrine)
Source: Endocrine - October 10, 2018 Category: Endocrinology Source Type: research

Long-term sequelae of the less than total thyroidectomy procedures for benign thyroid nodular disease
ConclusionThis is the first study with such a long duration of post-operative follow-up. The high rate of nodular recurrence in less than total thyroidectomy procedures along with the lifelong need for thyroxine supplementation suggest that a more conservative surgical approach is needed. When surgery is recommended, we suggest total thyroidectomy as the treatment of choice to avoid the recurrence of disease, the high cost associated with frequent follow-ups by means of sonography as well as thyroxine replacement therapy. (Source: Endocrine)
Source: Endocrine - October 9, 2018 Category: Endocrinology Source Type: research

Transmucosal oxygen tension of the clitoris: a new parameter for future investigations of the sexual, metabolic, and cardiovascular health of women
ConclusionsTmPO2 can be easily measured at the mucosal surface of clitoris. Large epidemiological studies in healthy and unhealthy women and in women with FSD are needed to establish both the normal range of TmPO2 and the meaning that different values of TmPO2 can have on sexual and general health of the women. (Source: Endocrine)
Source: Endocrine - October 9, 2018 Category: Endocrinology Source Type: research

Gonadotropin replacement in male thalassemia major patients with arrested puberty and acquired hypogonadotropic hypogonadism (AAH): preliminary results and potential factors affecting induction of spermatogenesis
(Source: Endocrine)
Source: Endocrine - October 8, 2018 Category: Endocrinology Source Type: research

Increased frequency of impaired fasting glucose and isolated systolic hypertension in Paget ’s disease of bone
AbstractPurposeScanty data about glucose metabolism and hypertension have been reported in Paget ’s disease of bone (PDB) to be related with increased cardiovascular mortality. The aim of the present study was to evaluate glucose and blood pressure levels in PDB, looking for their association with disease severity.MethodsWe performed an observational cross-sectional study in 54 patients with PDB and 54 age, sex and BMI-matched controls. Glucose and blood pressure levels and parameters of bone and mineral metabolism were assessed.ResultsPatients with PDB showed increased glucose levels (6.3  ± 1.7...
Source: Endocrine - October 3, 2018 Category: Endocrinology Source Type: research