Pharmacological effect of human melanocortin-2 receptor accessory protein 2 variants on hypothalamic melanocortin receptors
ConclusionsThis is the first dedicated description of single-cell transcriptome signature ofMrap2,Mc3r, andMc4r in the central nerve system and the first evidence describing the unique dimer formation, conformational change, and pharmacological effect of MRAP2 mutations on MC3R signaling. (Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Comparison of peripheral nerve protection between insulin-based glucose control and alpha lipoic acid (ALA) in the streptozotocin (STZ)-induced diabetic rat
In conclusion, our results suggest that the neuroprotective benefits of ALA and insulin-based glucose control may be similar, although glucose control may have had slightly more beneficial effects in this animal model of diabetes. Of note, glucose levels should be strictly controlled, including corrections for fluctuations in the glucose level, to obtain therapeutic benefits in DPN. (Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Screening of acromegaly in adults with obstructive sleep apnea: is it worthwhile?
(Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Total body irradiation for hematopoietic stem cell transplantation during early childhood is associated with the risk for diabetes mellitus
ConclusionsOur data suggested that TBI was a risk factor for DM after HSCT, and TBI before the age of six increased the possibility of DM without obesity. (Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Lactate induces expression and secretion of fibroblast growth factor-21 by muscle cells
(Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Thyroid cancer-related bone metastases: increasingly good prospects for treatment
(Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Predictivity of clinical, laboratory and imaging findings in diagnostic definition of palpable thyroid nodules. A multicenter prospective study
AbstractPurposeTo assess the role of clinical, biochemical, and morphological parameters, as added to cytology, for improving pre-surgical diagnosis of palpable thyroid nodules.MethodsPatients with a palpable thyroid nodule were eligible if surgical intervention was indicated after a positive or suspicious for malignancy FNAC (TIR 4 –5 according to the 2007 Italian SIAPEC-IAP classification), or two inconclusive FNAC at a ≥3 months interval, or a negative FNAC associated with one or more risk factor. Reference standard was histological malignancy diagnosis. Likelihood ratios of malignancy, sensitivity, specificity...
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Standardization of simple auxiliary method beneficial to total endoscopic thyroidectomy on patients with PTC, based on retrospective study of 356 cases
ConclusionThe clinical application of the SOSAM can effectively decrease the total operative time and hemorrhage during operation. Moreover, it can be used in a wider range of popularization to improve the operative effect for total endoscopic thyroidectomy. (Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Liquid L-thyroxine versus tablet L-thyroxine in patients on L- thyroxine replacement or suppressive therapy: a meta-analysis
ConclusionLiquid L-T4 is more efficient than tablet L-T4 in patients on L-T4 replacement or suppressive therapy with malabsorption. No significant differences were observed in patients without malabsorption. Further studies should be conducted to verify these findings. (Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Comment on Microsurgical therapy of pituitary adenomas
(Source: Endocrine)
Source: Endocrine - June 12, 2018 Category: Endocrinology Source Type: research

Treatment of multiresistant prolactinomas with a combination of cabergoline and octreotide LAR
ConclusionsThe addition of a somatostatin analog to ongoing CBG treatment may be effective in some patients with DA-resistant macroprolactinomas, independently of the adenoma ’s SSTR expression profile. (Source: Endocrine)
Source: Endocrine - June 11, 2018 Category: Endocrinology Source Type: research

Histology-proven recurrence in the lateral or central neck after systematic neck dissection for medullary thyroid cancer
ConclusionsPatients not biochemically cured, specifically those with extranodal growth at the initial operation, carry greater risks of node recurrence. (Source: Endocrine)
Source: Endocrine - June 5, 2018 Category: Endocrinology Source Type: research

High ApoD protein level in the round ligament fat depot of severely obese women is associated with an improved inflammatory profile
ConclusionsApoD variability between AT was consistent with different accumulation efficiencies and/or metabolic functions according to the anatomic location of fat depots. Most statistically significant correlations implicated ApoD protein levels, in agreement with protein accumulation in target tissues. These correlations associated higher ApoD levels in fat depots with improved metabolic health in severely obese women. (Source: Endocrine)
Source: Endocrine - June 4, 2018 Category: Endocrinology Source Type: research

Higher free triiodothyronine concentration is associated with lower prevalence of microangiopathic complications and better metabolic control in adult euthyroid people with type 1 diabetes
AbstractPurposeType 1 diabetes mellitus (T1DM) is a disorder of insulin deficiency but with a wide range of hormones simultaneously disturbed. The study was performed to explore relation of free triiodothyronine (FT3) with metabolic control and occurrence of microangiopathic complications.MethodsA total of 266 adult T1DM participants [56% men; 32 (interquartile range, IQR: 25 –39) years and disease duration 13 (IQR: 8–19) years] in euthyroid state with negative history for hypothyroidism were included to the study. Participants were screened for thyroid-stimulating hormone (TSH), free thyroxine (FT4) and FT3. M...
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Targeting human 8-oxoguanine DNA glycosylase to mitochondria protects cells from high glucose-induced apoptosis
ConclusionsThese findings indicated that high glucose induced cell apoptosis by causing the loss of MMP, the overproduction of ROS and mtDNA damage. Targeting DNA repair enzymes hOGG1 in mitochondria partly mitigated the high glucose-induced consequences, which shed new light for DR therapy. (Source: Endocrine)
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Association between LEPR, FTO, MC4R, and PPARG-2 polymorphisms with obesity traits and metabolic phenotypes in school-aged children
AbstractPurposeEvaluate the relationship of leptin receptor (LEPR) rs1137101, fat mass obesity-associated (FTO) receptors 9939609, melanocortin-4 receptors (MC4R) rs2229616 and rs17782313, and proliferator-activated receptor-gamma (PPARG) rs1801282 with clinical and metabolic phenotypes in prepubertal children.Research questionWhat is the effect of polymorphisms on clinical and metabolic phenotypes in prepubertal children?MethodsA cross-sectional descriptive study was performed to evaluate anthropometric features, percentage body fat (%BF), biochemical parameters, and genotype in 773 prepubertal children.ResultsFTO rs99396...
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Correlation between MGMT promoter methylation and response to temozolomide-based therapy in neuroendocrine neoplasms: an observational retrospective multicenter study
ConclusionAccording to our results,MGMT methylation status, evaluated with methylation specific-polymerase chain reaction or pyrosequencing, should have an important role in patients with metastatic NENs, in order to guide therapeutic options. These results need further confirmation with prospective studies. (Source: Endocrine)
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy
AbstractPurposeThe purpose of this study is to summarize the effectiveness and safety of metreleptin in patients with congenital or acquired generalized lipodystrophy.MethodsPatients (n = 66) aged ≥6 months had lipodystrophy, low circulating leptin, and ≥1 metabolic abnormality (diabetes mellitus, insulin resistance, or hypertriglyceridemia). Metreleptin dose (once or twice daily) was titrated to a mean dose of 0.10 mg/kg/day with a maximum of 0.24 mg/kg/day. Means and changes from baseline to month 12 were assessed for glycated hemoglobin (HbA1c), fasting triglycerides (TGs), and fasting ...
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Brown tumors of primary hyperparathyroidism may be a source of extrarenal 1,25-dihydroxyvitamin D production
(Source: Endocrine)
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Impact of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the risk of malignancy estimated by the ultrasonographic classification of the American Thyroid Association (ATA) in thyroid nodules & gt;1  cm
(Source: Endocrine)
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Duodeno-jejunal bypass restores β-cell hypersecretion and islet hypertrophy in western diet obese rats
ConclusionDJB surgery improves fasting glycemia and insulin action in skeletal muscle. Better endocrine pancreatic morphofunction was associated, at least in part, with the regulation of the cholinergic and cAMP pathways, and improvements in syntaxin-1 islet protein content induced by DJB. (Source: Endocrine)
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Voice quality preservation in thyroid surgery with neuromonitoring
ConclusionsThe use of neuromonitoring in thyroid surgery is beneficial for patients to improve voice quality. The identification and preservation of EBSLNs is crucial to eliminate altered voice after thyroidectomy. (Source: Endocrine)
Source: Endocrine - May 5, 2018 Category: Endocrinology Source Type: research

Natural history and clinical characteristics of 50 patients with Wolfram syndrome
ConclusionsThe early presence of a non-autoimmune insulin dependent DM, should alert us of an “infrequent” diabetes syndrome. Wolfram’s presumptive diagnosis could be established if juvenile-onset DM occurs concomitantly with OA, and this visual impairment is not attributable to diabetic retinopathy. Despite the long period of evolution of DM and altered values of HbA1c, the prevalence of microvascular complications in the sample are low. (Source: Endocrine)
Source: Endocrine - May 4, 2018 Category: Endocrinology Source Type: research

Kisspeptin and LH pulsatile temporal coupling in PCOS patients
ConclusionsThe study of the endogenous kisspeptin and LH pulsatile release revealed the temporal coupling of kisspeptin with LH secretory pulses only in eumenorrheic. This data supports the hypothesis that neuroendocrine impairments in PCOS affect the coupling of kisspeptin with LH pulses and potentially worsen as the disease progresses, becoming unequivocally evident in oligomenorrheic PCOS patients. (Source: Endocrine)
Source: Endocrine - May 4, 2018 Category: Endocrinology Source Type: research

The emerging role of aldosterone/mineralocorticoid receptors in the pathogenesis of erectile dysfunction
ConclusionIn conclusion, we summarize the current evidence to highlight the potential role of aldosterone in erectile dysfunction and provide critical insights into the treatment of the disease. (Source: Endocrine)
Source: Endocrine - May 2, 2018 Category: Endocrinology Source Type: research

Microbiota and metabolic diseases
AbstractThe microbiota is a complex ecosystem of microorganisms consisting of bacteria, viruses, protozoa, and fungi, living in different districts of the human body, such as the gastro-enteric tube, skin, mouth, respiratory system, and the vagina. Over 70% of the microbiota lives in the gastrointestinal tract in a mutually beneficial relationship with its host. The microbiota plays a major role in many metabolic functions, including modulation of glucose and lipid homeostasis, regulation of satiety, production of energy and vitamins. It exerts a role in the regulation of several biochemical and physiological mechanisms th...
Source: Endocrine - May 2, 2018 Category: Endocrinology Source Type: research

The timing of parathyroid hormone measurement defines the cut-off values to accurately predict postoperative hypocalcemia: a prospective study
AbstractPurposeSerum intact parathyroid hormone (iPTH) level is an early marker of post-thyroidectomy hypocalcemia. However, lack of methodological standardization to define timing and cut-off points of iPTH measurement limit its clinical applicability. Here, we evaluated the relationship between two distinct postoperative time sampling and iPTH accuracy on predicting hypocalcemia.MethodsiPTH was measured within 4  h after surgery (iPTH 4 h) and on the morning of the first postoperative day (iPTH 1st PO). Hypocalcemia was defined by levels of total calcium corrected by serum albumin ≤ 8.0&thi...
Source: Endocrine - May 2, 2018 Category: Endocrinology Source Type: research

Alteration in skeletal muscle mass in women with subclinical hypercortisolism
ConclusionsThis study showed that women with SH had lower skeletal muscle mass, especially of the lower limb, and suggested that subtle cortisol excess also has adverse effects on skeletal muscle metabolism. (Source: Endocrine)
Source: Endocrine - May 1, 2018 Category: Endocrinology Source Type: research

The associations of metabolic syndrome with incident hypertension, type 2 diabetes mellitus and chronic kidney disease: a cohort study
ConclusionsMetS may help identify individuals with metabolic profiles that confer incremental risks for multiple diseases. Additionally, several components of the syndrome should be considered by clinicians, as they show stronger associations with specific diseases than MetS. (Source: Endocrine)
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

Complete evaluation of pituitary tumours in a single tertiary care institution
AbstractIntroductionWe retrospectively evaluated all patients with pituitary tumours treated in our department from 1/1/1997 to 01/11/2014.Patients and methodsTwo hundred and fifteen patients (124 females, 91 males, mean age 50.9 years) were treated because of pituitary tumours. All patients underwent basal hormonal analysis and when required dynamic testing in order to check for hormonal activity. Pituitary masses were divided into groups concerning their hormonal status and were further classified according to gender, age at diagnosis, tumour size, and the development of postoperative pituitary insufficiency when neurosu...
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

Low-dose Synachten test with measurement of salivary cortisol in adult patients with β-thalassemia major
AbstractPurposeBeta-thalassemia major is a severe, congenital hematological disorder and, if untreated, leads to early mortality. Progress in therapeutical strategies improved clinical outcomes and life expectancy; however, increased survival led to the development of new disorders, including endocrinopathies. Little is known on the possible impairment of adrenocortical function, a potentially life-threatening condition, in long-term thalassaemic survivors. We therefore decided to assess adrenal reserve and the value of salivary cortisol during ACTH stimulation in the diagnosis of adrenocortical insufficiency in adult pati...
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

Longitudinal AddiQoL scores may identify higher risk for adrenal crises in Addison ’s disease
ConclusionsThese are the first data showing the course of QoL during a period of ten months in patients with AD. Incidence of AC exceeds previous data. Our data show, that subjective precrises in AD associate with lower QoL. AC, as well as precrises affect intraindividual AddiQol-scores over time with a trend to a stronger fluctuation. Longitudinal AddiQol scores and self-reporting of precrises via patient diaries are additional clinical tools to identify higher risk for critical events. (Source: Endocrine)
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

Pancreatic neuroendocrine tumors in MEN1 disease: a mono-centric longitudinal and prognostic study
ConclusionsIn our study pNETs in MEN1+ and pNETs in MEN1 − don’t significantly differ for prognosis but only for clinical features. p-NET stage disease and prognosis can be positively influenced by early diagnosis and screening in index patients’ first-degree relatives (Source: Endocrine)
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

IGF-1-based screening reveals a low prevalence of acromegaly in patients with obstructive sleep apnea
ConclusionsOur data demonstrate a low prevalence of acromegaly in patients with OSAS. Until data from population-based studies is available we suggest restricting screening for acromegaly in OSAS to those patients who have additional clinical features of acromegaly. (Source: Endocrine)
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

Gain-of-function SNPs in NLRP3 and IL1B genes confer protection against obesity and T2D: undiscovered role of inflammasome genetics in metabolic homeostasis?
(Source: Endocrine)
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

Morphologic and molecular pathway of cushing syndrome cardiomyopathy
(Source: Endocrine)
Source: Endocrine - April 10, 2018 Category: Endocrinology Source Type: research

A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms
ConclusionsCgA-score encompasses a wide range of comorbidities and represents a promising tool that could improve diagnostic performance of CgA in everyday clinical practice. (Source: Endocrine)
Source: Endocrine - April 9, 2018 Category: Endocrinology Source Type: research

Predictors of surgical outcome and early criteria of remission in acromegaly
AbstractBackgroundTranssphenoidal surgery (TSS) is the cornerstone of acromegaly treatment, however there are no robust predictors of surgical outcome and remission can only be defined three months after surgery.PurposeTo analyze if biochemical, demographical, radiological, and immunohistochemical characteristics are predictors of surgical remission and investigate if immediate postoperative GH and IGF-I levels can help defining remission earlier.MethodsConsecutive acromegaly patients submitted to TSS between 2013-2016 were evaluated. Remission criteria was defined as normal IGF-I and GH
Source: Endocrine - April 6, 2018 Category: Endocrinology Source Type: research

Increased cortisol metabolism in women with pregnancy-related hypertension
AbstractPurposeThe diminished function of 11 β-hydroxysteroid dehydrogenase 2 (11β-HSD2) was found in placentae from preeclamptic pregnancies. Here, we examine the overall maternal glucocorticoid balance in pregnancy-related hypertension. We aim to answer the question if the functions of primary enzymes involved in cortisol metabolism: 11β- HSD1 and 11β-HSD2 and 5-reductases (both 5α- and 5β) are altered in the course of hypertensive pregnancy.MethodsWe determined plasma and urinary cortisol and cortisone as well as their urinary tetrahydro- and allo-tetrahydrometabolites, both in free and co...
Source: Endocrine - April 2, 2018 Category: Endocrinology Source Type: research

G3 GEP NENs category: are basic and clinical investigations well integrated?
AbstractGastroenteropancreatic neuroendocrine neoplasms grade 3, all of them with>20% Ki-67, can be heterogeneous on the basis of their morphological features, comprising well and poorly differentiated neoplasms; the former are named tumors and the latter carcinomas. Several papers about gastroenteropancreatic neuroendocrine neoplasms grade 3 heterogeneity have been reporting over the last years by clinicians and pathologists, indicating that the differential diagnosis between named tumors grade 3 and named carcinomas grade 3 may be relevant in defining a different approach in terms of characterization of disease, stagi...
Source: Endocrine - March 10, 2018 Category: Endocrinology Source Type: research

MiR-145 improves macrophage-mediated inflammation through targeting Arf6
ConclusionsBy means of reducing the expression of Arf6 and subsequent signal transduction via NF-kappaB, miR-145 plays a role in inhibiting the secretion of inflammatory factors and then improving the inflammatory status. MiR-145 might be one of the candidates for anti-inflammatory treatment for metabolic diseases. (Source: Endocrine)
Source: Endocrine - March 10, 2018 Category: Endocrinology Source Type: research

Blood pressure variability in primary hyperparathyroidism: more data needed
(Source: Endocrine)
Source: Endocrine - March 10, 2018 Category: Endocrinology Source Type: research

Oro-dental pathologies in acromegaly
ConclusionIn our large series of patients, four of five patients were affected by ODP at any time during the course of the disease. The results highlight the importance of early identification and treatment of oro-dental problems in patients with acromegaly as hallmarks of the disease. (Source: Endocrine)
Source: Endocrine - March 8, 2018 Category: Endocrinology Source Type: research

Maternal soybean diet during lactation alters breast milk composition and programs the lipid profile in adult male rat offspring
ConclusionsMaternal intake of soybeans in lactation changes the lipid content of breast milk and programmed offspring for phenotype of the lower metabolic risk, with lower serum TC and LDL, and seems to protect the progeny of alterations in glucose metabolism despite the higher lipid content. The difference in fat content of breast milk and the higher isoflavones content of soy diet are possible imprinting factors that could program the offspring. (Source: Endocrine)
Source: Endocrine - March 8, 2018 Category: Endocrinology Source Type: research

Novel mutation of PPOX gene in a patient with abdominal pain and syndrome of inappropriate antidiuresis
ConclusionsOur case highlights the importance of considering VP in the differential diagnosis of SIAD and underlines the role of genetic screening in the management of such patients. The finding of a novel mutation of PPOX gene in our index case has allowed to recognize an affected family. (Source: Endocrine)
Source: Endocrine - March 7, 2018 Category: Endocrinology Source Type: research

Physiopathological relationship between chronic obstructive pulmonary disease and insulin resistance
ConclusionPatients with COPD should be screened for abnormalities in insulin sensitivity in order to reduce morbidity and improve health status in this population. (Source: Endocrine)
Source: Endocrine - March 6, 2018 Category: Endocrinology Source Type: research

Clinical study of pregnancy-associated fulminant type 1 diabetes
AbstractBackgroundStudies reported that fulminant type 1 diabetes (fT1DM) can occurred during pregnancy or within 2 weeks after delivery, and was defined as pregnancy-associated fulminant type 1 diabetes (PF). In PF patients, plasma glucose (PG) levels have an abrupt rise while glycated hemoglobin (HbA1C) levels are not markedly elevated, resulting in a sharply increased PG/HbA1C ratio.MethodsWe studied 30 PF patients, 21 non-pregnant fulminant type 1 diabetes (NPF) patients, and 26 female patients of child-bearing age (13 –49 years) with diabetic ketoacidosis (DKA), all from China. We analyzed the PG/HbA1C ratio amo...
Source: Endocrine - March 2, 2018 Category: Endocrinology Source Type: research

Copeptin in hyponatremia: is there a role for this biomarker in the diagnostic workup?
(Source: Endocrine)
Source: Endocrine - March 1, 2018 Category: Endocrinology Source Type: research

Predicting an adrenal crisis: can we do it?
(Source: Endocrine)
Source: Endocrine - March 1, 2018 Category: Endocrinology Source Type: research

Lower urinary tract symptoms (LUTS) in males with type 2 diabetes recently treated with SGLT2 inhibitors —overlooked and overwhelming? A retrospective case series
(Source: Endocrine)
Source: Endocrine - February 23, 2018 Category: Endocrinology Source Type: research