LncRNA PVT1 induces aggressive vasculogenic mimicry formation through activating the STAT3/Slug axis and epithelial-to-mesenchymal transition in gastric cancer
ConclusionOur results shed light on the role of PVT1 in gastric cancer cell-dependent VM formation. Our findings provide valuable clues for the design of new anti-angiogenic therapeutic strategies. The PVT1/STAT3 axis may serve as a potential target in gastric cancer treatment. (Source: Cellular Oncology)
Source: Cellular Oncology - July 29, 2020 Category: Cancer & Oncology Source Type: research

Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression
ConclusionMTX triggers ICD by activating eIF2 α via PERK/GCN2 upregulation in prostate cancer cells. MTX-induced PERK expression upregulation depends on the p53 pathway, while that of GCN2 requires further investigation. (Source: Cellular Oncology)
Source: Cellular Oncology - July 24, 2020 Category: Cancer & Oncology Source Type: research

Aberrantly expressed Bruton ’s tyrosine kinase preferentially drives metastatic and stem cell-like phenotypes in neuroblastoma cells
ConclusionsFrom our data we conclude that BTK is a therapeutically targetable driver of neuroblastoma.Graphical abstract (Source: Cellular Oncology)
Source: Cellular Oncology - July 23, 2020 Category: Cancer & Oncology Source Type: research

Metabolomic profiling of mouse mammary tumor-derived cell lines reveals targeted therapy options for cancer subtypes
ConclusionsOur results demonstrate the feasibility of metabolic profiling to develop novel personalized therapy strategies for different subtypes of breast cancer.Graphical abstractSchematic overview of the experimental design for drug selection based on breast cancer subtype-specific metabolism. The epithelial mesenchymal transition (EMT) and papillary tumors are histologically distinct mouse mammary tumor subtypes from the MMTV-Myc mouse model. Cell lines derived from tumors can be used to determine metabolic pathways that can be used to select drug candidates for each subtype. (Source: Cellular Oncology)
Source: Cellular Oncology - July 20, 2020 Category: Cancer & Oncology Source Type: research

Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation
ConclusionOur results indicate that bufalin acts as a potential anti-HCC therapeutic candidate to block HBx-induced AR/CCRK/ β-catenin signaling by targeting AR and CCRK, which may provide a novel strategy for the treatment of HBV-associated HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - July 4, 2020 Category: Cancer & Oncology Source Type: research

Role of the bone microenvironment in bone metastasis of malignant tumors - therapeutic implications
ConclusionsHere, we review the normal bone microenvironment, bone microenvironment-related factors that promote bone metastasis, as well as mechanisms underlying bone metastasis. In addition, we elude on directions for clinical bone metastasis management, focusing on potential therapeutic approaches to target bone microenvironment-related factors, including bisphosphonate, denosumab, CXCR4/CXCL12 antagonists and cathepsin K inhibitors. (Source: Cellular Oncology)
Source: Cellular Oncology - July 4, 2020 Category: Cancer & Oncology Source Type: research

Nomograms using a small panel of genes for predicting the diagnosis and aggressiveness of prostate cancer
(Source: Cellular Oncology)
Source: Cellular Oncology - July 2, 2020 Category: Cancer & Oncology Source Type: research

Enhanced immunogenicity of leukemia-derived exosomes via transfection with lentiviral vectors encoding costimulatory molecules
Conclusions: This study sheds light on the feasibility of obtaining LEXs that overexpress costimulatory molecules via genetically modified leukemia cells, thereby enhancing their anti-leukemia immunity and providing a potential therapeutic strategy that contributes to leukemia immunotherapy. (Source: Cellular Oncology)
Source: Cellular Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

BAG3 interacts with p53 in endometrial carcinoma
(Source: Cellular Oncology)
Source: Cellular Oncology - June 23, 2020 Category: Cancer & Oncology Source Type: research

LINC01419 promotes cell proliferation and metastasis in hepatocellular carcinoma by enhancing NDRG1 promoter activity
ConclusionsFrom our data we conclude that LINC01419 acts clinically, functionally and mechanistically oncogenic in HCC. LINC01419 may, therefore, serve as a promising prognostic indicator and therapeutic target for HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - June 15, 2020 Category: Cancer & Oncology Source Type: research

EBV-miR-BART10-3p and EBV-miR-BART22 promote metastasis of EBV-associated gastric carcinoma by activating the canonical Wnt signaling pathway
ConclusionsFrom our data we conclude that BART10-3p and BART22 play vital roles in promoting EBVaGC metastasis by targeting APC and DKK1 and, subsequently, activating the Wnt signaling pathway, thereby providing novel prognostic biomarkers and potential therapeutic targets for EBVaGC. (Source: Cellular Oncology)
Source: Cellular Oncology - June 12, 2020 Category: Cancer & Oncology Source Type: research

DNMT1 as a therapeutic target in pancreatic cancer: mechanisms and clinical implications
ConclusionsHerein, the expression profiles, oncogenic roles, regulators and inhibitors of DNMT1 in PDACs are presented and discussed. DNMT1 is overexpressed in PDAC cases compared with non-cancerous pancreatic ducts, and its expression gradually increases from pre-neoplastic lesions to PDACs. DNMT1 plays oncogenic roles in suppressing PDAC cell differentiation and in promoting their proliferation, migration and invasion, as well as in induction of the self-renewal capacity of PDAC cancer stem cells. These effects are achieved via promoter hypermethylation of tumor suppressor genes, including cyclin-dependent kinase inhibit...
Source: Cellular Oncology - June 5, 2020 Category: Cancer & Oncology Source Type: research

Selective capture of plasma cell-free tumor DNA on magnetic beads: a sensitive and versatile tool for liquid biopsy
ConclusionsWe present a robust, reproducible, and highly sensitive method for the analysis of mutation statuses in liquid biopsies. The SCC-MAG method can readily be applied to any nucleic acid target for diagnostic purposes upon careful design of the specific capture probes, and can be multiplexed by several probes to identify multiple targets. (Source: Cellular Oncology)
Source: Cellular Oncology - June 3, 2020 Category: Cancer & Oncology Source Type: research

Noncoding RNAs in oral premalignant disorders and oral squamous cell carcinoma
ConclusionsKnowledge on ncRNAs has added an extra layer of complexity to our understanding of the malignant progression of oral mucosal diseases. The identification of ncRNAs in multiple body fluids as biomarkers may provide new diagnostic options that can be used for the diagnosis and prognosis of OPMDs and OSCC, respectively. Despite overall advances that have been made in cancer treatment, the treatment options for OPMDs and OSCC are still limited. Several studies have shown that ncRNA-based treatment regimens may hold promise as alternative methods for treating OPMDs and OSCC. The use of ncRNAs as therapeutic agents, i...
Source: Cellular Oncology - June 3, 2020 Category: Cancer & Oncology Source Type: research

Non-coding RNAs underlying chemoresistance in gastric cancer
ConclusionsIn this review, we summarize some of the well-known ncRNAs that play a role in the development and progression of GC. We also review the application of such ncRNAs in clinical diagnostics and trials as potential biomarkers. Obviously, a deeper understanding of the biology and function of ncRNAs underlying chemoresistance can broaden horizons toward the development of personalized therapy against GC. (Source: Cellular Oncology)
Source: Cellular Oncology - June 3, 2020 Category: Cancer & Oncology Source Type: research

Modeling of the immune response in the pathogenesis of solid tumors and its prognostic significance
ConclusionsDevelopment of solid tumors may occur both during acute and chronic phases of inflammation. Differences in the regulation of immune responses between precancerous states and the cancers resulting from them emphasize the importance of immunosuppressive factors in oncogenesis. Cancer cells may, through their secretory activity and extracellular transport mechanisms, enhance deterioration of the immune system which, in turn, may have prognostic implications. (Source: Cellular Oncology)
Source: Cellular Oncology - June 2, 2020 Category: Cancer & Oncology Source Type: research

Functional and metabolic targeting of natural killer cells to solid tumors
ConclusionsIn this review, we address the current knowledge on the presence and immunometabolic roles of NK cells in solid tumors as well as the strategies developed to restore NK cell activities in these conditions, with the ultimate goal of enhancing persistence, trafficking, cytotoxicity and metabolic functions. (Source: Cellular Oncology)
Source: Cellular Oncology - June 2, 2020 Category: Cancer & Oncology Source Type: research

Ascofuranone suppresses invasion and F-actin cytoskeleton organization in cancer cells by inhibiting the mTOR complex 1 signaling pathway
ConclusionsOur data indicate that ascofuranone suppresses IGF-1-induced cancer cell migration and invasion by blocking actin cytoskeleton organization and FAK activation through inhibition of the mTORC1 pathway, and reveal a novel anti-metastatic function of this compound. (Source: Cellular Oncology)
Source: Cellular Oncology - June 2, 2020 Category: Cancer & Oncology Source Type: research

HIF1A expression correlates with increased tumor immune and stromal signatures and aggressive phenotypes in human cancers
ConclusionsHIF1A upregulation correlates with increased tumor immune and stromal signatures and aggressive phenotypes in human cancers. Our analysis may provide new insights into the role ofHIF1A in tumor biology and clinical management. (Source: Cellular Oncology)
Source: Cellular Oncology - June 1, 2020 Category: Cancer & Oncology Source Type: research

Sp1-mediated up-regulation of lnc00152 promotes invasion and metastasis of retinoblastoma cells via the miR-30d/SOX9/ZEB2 pathway
ConclusionsOur data indicate that Lnc00152 may be associated with retinoblastoma invasion, metastasis and prognosis. In addition, we conclude that Lnc00152, which can be activated by Sp1, can induce EMT via the miR-30d/SOX9/ZEB2 pathway and, by doing so, promote the invasion and metastasis of retinoblastoma cells. (Source: Cellular Oncology)
Source: Cellular Oncology - June 1, 2020 Category: Cancer & Oncology Source Type: research

Association of Jagged1 expression with malignancy and prognosis in human pancreatic cancer
ConclusionsFrom our data we conclude that JAG1 may be a promising therapeutic target in pancreatic cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - June 1, 2020 Category: Cancer & Oncology Source Type: research

A lectin-based glycomic approach identifies FUT8 as a driver of radioresistance in oesophageal squamous cell carcinoma
ConclusionsOur results indicate that FUT8 functions as a driver of radio-resistance in ESCC by targeting CD147. Therefore, FUT8 may serve as a marker for predicting the response to radiation therapy in patients with ESCC. (Source: Cellular Oncology)
Source: Cellular Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Pharmacogenomics of 5-fluorouracil in colorectal cancer: review and update
ConclusionsIn this article we systematically review and update current knowledge on 5-FU pharmacogenomics related to drug uptake and activation, the expression and activity of target enzymes (DPD, TS and MTHFR) and key signaling pathways in CRC. Furthermore, a summary of drug combination strategies aimed at targeting specific genes and/or pathways to reverse 5-FU resistance is provided. Based on this, we suggest that causal relationships between genes, pathways and drug sensitivity should be systematically considered from a multidimensional perspective. In the design of research methods, emerging technologies such as CRISP...
Source: Cellular Oncology - May 30, 2020 Category: Cancer & Oncology Source Type: research

Systematic profiling of immune signatures identifies prognostic predictors in lung adenocarcinoma
ConclusionsOur results add to the current knowledge of immune processes in LUADs and underscore the critical role of the immune microenvironment in LUAD patient outcome. (Source: Cellular Oncology)
Source: Cellular Oncology - May 28, 2020 Category: Cancer & Oncology Source Type: research

Pervasive promoter hypermethylation of silenced TERT alleles in human cancers
ConclusionsOur findings suggest that hypermethylation of theTERT promoter alleles signals transcriptional repression of those alleles, leading to attenuation ofTERT activation in cancer cells. This type of fine tuning ofTERT expression may account for the modest activation ofTERT expression in most cancers. (Source: Cellular Oncology)
Source: Cellular Oncology - May 28, 2020 Category: Cancer & Oncology Source Type: research

CD105 is a prognostic marker and valid endothelial target for microbubble platforms in cholangiocarcinoma
ConclusionOur results indicate that CD105 is a biomarker eminently suitable for cholangiocarcinoma targeting using functionalised microbubbles. (Source: Cellular Oncology)
Source: Cellular Oncology - May 28, 2020 Category: Cancer & Oncology Source Type: research

LINC00858 knockdown inhibits gastric cancer cell growth and induces apoptosis through reducing WNK2 promoter methylation
ConclusionsTogether, these findings indicate that silencing of LINC00858 increases WNK2 expression and inhibits the MAPK signaling pathway, thereby inhibiting GC growth and development. Our data highlight LINC00858 as a potential target in GC therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - May 24, 2020 Category: Cancer & Oncology Source Type: research

Pure high-grade papillary urothelial bladder cancer: a luminal-like subgroup with potential for targeted therapy
ConclusionsOur data should help guiding the selection of targeted therapies for investigation in future clinical trials and, additionally, may provide a basis for prospective mechanistic studies of pTa HG pathogenesis. (Source: Cellular Oncology)
Source: Cellular Oncology - May 22, 2020 Category: Cancer & Oncology Source Type: research

Downregulation of beta-catenin in chemo-tolerant TNBC through changes in receptor and antagonist profiles of the WNT pathway: Clinical and prognostic implications
ConclusionsOur data suggest that reduced nuclear expression of beta-catenin in NACT TNBC samples, due to downregulation of its receptors and upregulation of its antagonists through promoter hypomethylation of the WNT pathway, plays an important role in chemo-tolerance. (Source: Cellular Oncology)
Source: Cellular Oncology - May 19, 2020 Category: Cancer & Oncology Source Type: research

Current insights into the metastasis of epithelial ovarian cancer - hopes and hurdles
ConclusionsHere, we review our current understanding of the most updated cellular and molecular mechanisms underlying EOC metastasis and discuss in more detail two main metastatic routes of EOC, i.e., transcoelomic metastasis and hematogenous metastasis. The emerging concept of blood-borne EOC metastasis has led to exploration of the significance of circulating tumor cells (CTCs) as novel and non-invasive prognostic markers in this daunting cancer. We also evaluate the role of tumor stroma, including cancer associated fibroblasts (CAFs), tumor associated macrophages (TAMs), endothelial cells, adipocytes, dendritic cells an...
Source: Cellular Oncology - May 16, 2020 Category: Cancer & Oncology Source Type: research

Zebularine-induced myeloma cell death is accompanied by decreased c-Myc expression
ConclusionsOur study revealed novel effects of zebularine on MM that may have potential implications for DNA methylation-based therapies. (Source: Cellular Oncology)
Source: Cellular Oncology - May 11, 2020 Category: Cancer & Oncology Source Type: research

The PI3K/mTOR dual inhibitor GSK458 potently impedes ovarian cancer tumorigenesis and metastasis
ConclusionsBased on our results, we conclude that GSK458 may serve as an attractive candidate to treat ovarian cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - May 8, 2020 Category: Cancer & Oncology Source Type: research

The hedgehog pathway regulates cancer stem cells in serous adenocarcinoma of the ovary
ConclusionsOur results indicate that thehedgehog pathway plays an important role in maintaining the integrity of CSCs in HGSOC and could be a potential therapeutic target. (Source: Cellular Oncology)
Source: Cellular Oncology - May 8, 2020 Category: Cancer & Oncology Source Type: research

WNT1, a target of miR-34a, promotes cervical squamous cell carcinoma proliferation and invasion by induction of an E-P cadherin switch via the WNT/ β-catenin pathway
ConclusionsFrom our results we conclude that WNT1, as a target of miR-34a, can promote cervical SCC cell proliferation and invasion by induction of an E-P cadherin switch via the WNT1/ β-catenin pathway. Our results may provide new options for the treatment of patients with cervical SCC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 16, 2020 Category: Cancer & Oncology Source Type: research

CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145
ConclusionsFrom our data we conclude that circBIRC6 overexpression promotes NSCLC cell progression, possibly by sponging miR-145. (Source: Cellular Oncology)
Source: Cellular Oncology - April 15, 2020 Category: Cancer & Oncology Source Type: research

Effect of EphA2 knockdown on melanoma metastasis depends on intrinsic ephrinA1 level
ConclusionsFrom our data we conclude that evaluation of ephrinA1 levels may be helpful for the application of EphA2-targeted therapies and for prognostic predictions in melanoma patients. (Source: Cellular Oncology)
Source: Cellular Oncology - April 14, 2020 Category: Cancer & Oncology Source Type: research

Salivary microRNAs identified by small RNA sequencing as potential predictors of response to intensity-modulated radiotherapy in head and neck cancer patients
ConclusionsWe conclude that salivary miR-15a-5p may represent a potential biomarker for individualized treatment decision-making in HNSCC patients. (Source: Cellular Oncology)
Source: Cellular Oncology - April 7, 2020 Category: Cancer & Oncology Source Type: research

Overexpression of Sal-like protein 4 in head and neck cancer: epigenetic effects and clinical correlations
AbstractBackgroundSal-like protein 4 (SALL4), an embryonic stem cell factor, has been reported to play an essential role in embryogenesis and oncogenesis. As yet, however, the expression and role of this transcription factor in head and neck squamous cell carcinoma (HNSCC) has not been established.MethodsWe assessedSALL4 mRNA expression in a well-characterised dataset of 230 HNSCC samples (test cohort 110 cases and validation cohort 120 cases). We also transfected HNSCC cells (FaDu and UM-SCC-6) with SALL4 siRNA and assessed its effects on proliferation and expression of specific epigenetic factors in order to uncover the ...
Source: Cellular Oncology - April 2, 2020 Category: Cancer & Oncology Source Type: research

IL-17A and IL-17F orchestrate macrophages to promote lung cancer
ConclusionsOur data indicate that IL-17A/F act through immune cell orchestration, i.e., of macrophages, to promote lung cancer cell growth and progression. In addition, our data provide a link between IL-17A/F activity and lung cancer cell-macrophage crosstalk. (Source: Cellular Oncology)
Source: Cellular Oncology - March 29, 2020 Category: Cancer & Oncology Source Type: research

PFKP is highly expressed in lung cancer and regulates glucose metabolism
ConclusionsOur data indicate that PFKP is highly expressed in lung cancer tissues and cell lines and is associated with tumor size and patient prognosis. As such, PFKP may serve as a prognostic biomarker. We also found that PFKP regulates the level of glycolysis in lung cancer cells and is associated with lung cancer cell proliferation. These data may be instrumental for the design of new lung cancer treatment options. (Source: Cellular Oncology)
Source: Cellular Oncology - March 26, 2020 Category: Cancer & Oncology Source Type: research

The role of ErbB4 in cance r
ConclusionsHere, we discuss the role of ErbB4 in normal physiology and in breast, lung, colorectal, gastric, pancreatic, prostate, bladder, and brain cancers, as well as in hepatocellular carcinoma, cholangiocarcinoma, and melanoma. Understanding the role of ErbB4 in cancer is not only important for the treatment of tumors, but also for the treatment of other disorders in which ErbB4 plays a major role, e.g. cardiovascular disease. (Source: Cellular Oncology)
Source: Cellular Oncology - March 26, 2020 Category: Cancer & Oncology Source Type: research

Insulinoma-associated protein 1 (INSM1): a potential biomarker and therapeutic target for neuroendocrine tumors
ConclusionsHere, we highlight INSMI expression, as well as its diagnostic significance and use as a therapeutic target in various neuroendocrine tumors. Targeting signaling pathways or gene expression alterations associated with INSM1 expression may be instrumental for the design of novel therapeutic strategies for neuroendocrine tumors. (Source: Cellular Oncology)
Source: Cellular Oncology - March 26, 2020 Category: Cancer & Oncology Source Type: research

Dp44mT, an iron chelator, suppresses growth and induces apoptosis via RORA-mediated NDRG2-IL6/JAK2/STAT3 signaling in glioma
ConclusionsOur data indicate that Dp44mT may serve as an effective drug for the treatment of glioma by targeting RORA and enhancing NDRG2-mediated IL-6/JAK2/STAT3 signaling. (Source: Cellular Oncology)
Source: Cellular Oncology - March 23, 2020 Category: Cancer & Oncology Source Type: research

CXCL-10: a new candidate for melanoma therapy?
ConclusionsRecent studies indicate that the CXCL10/CXCR3 axis may act as a double-edged sword in terms of pro- and anti-cancer activities in a variety of tissues and cells, especially in melanoma cells and their microenvironments. Most of these activities arise from the CXCR3 splice variants CXCR3-A, CXCR3-B and CXCR3-Alt. In this review, we discuss the pro- and anti-cancer properties of CXCL10 in various types of tissues and cells, particularly melanoma cells, including its potential as a therapeutic target. (Source: Cellular Oncology)
Source: Cellular Oncology - March 23, 2020 Category: Cancer & Oncology Source Type: research

Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer
ConclusionsFrom our data we conclude that AURKA and TPX2 may act as KRAS biomarkers in PDAC that can predict a worse prognosis, and that AURKA or TPX2 targeting in PDAC cells may reduce their transformed phenotype. These results indicate that AURKA and TPX2 may serve as promising targets to be explored forKRAS-mutant PDAC therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - March 19, 2020 Category: Cancer & Oncology Source Type: research

Association of DCBLD2 upregulation with tumor progression and poor survival in colorectal cancer
AbstractPurposeDCBLD2 expression dysregulation has been reported in several types of human cancer. As yet, however, the role of DCBLD2 in colorectal cancer (CRC) is not known.MethodsCRC tissues were obtained from patients undergoing surgery from February 2009 to May 2014 (n = 90). Tissue microarray construction and immunohistochemistry were carried out to determine DCBLD2 expression. In vivo studies were performed in 4-week-old BALB/c nude mice. In vitro studies were conducted using CRC-derived HT29 and HCT116 cell lines.ResultsDCBLD2 expression was found to be significantly increased in CRC tissues compared ...
Source: Cellular Oncology - March 12, 2020 Category: Cancer & Oncology Source Type: research

Identification of a stemness-related gene panel associated with BET inhibition in triple negative breast cancer
ConclusionsWe identified a stemness-related gene panel associated with JQ1 and describe how this inhibitor modifies the stemness landscape in TNBC. Therefore, we propose a novel role for JQ1 as a stemness-targeting drug. Loss of the stem cell phenotype via JQ1 treatment could lead to less aggressive and more chemo-sensitive tumours, reflecting a better patient prognosis. Thus, the identified gene panel may be of interest for the clinical management of patients with aggressive TNBC. (Source: Cellular Oncology)
Source: Cellular Oncology - March 12, 2020 Category: Cancer & Oncology Source Type: research

Prevalence of CD8 + cytotoxic lymphocytes in human neoplasms
ConclusionThese data support the concept that among most tumor types at least some individual cancers may benefit from treatment with immune checkpoint inhibitors. (Source: Cellular Oncology)
Source: Cellular Oncology - March 5, 2020 Category: Cancer & Oncology Source Type: research

Long noncoding RNA LINC01234 silencing exerts an anti-oncogenic effect in esophageal cancer cells through microRNA-193a-5p-mediated CCNE1 downregulation
ConclusionsWe found that silencing of LINC01234 suppresses EC development by inhibiting CCNE1 through competitively binding to miR-193a-5p, which suggests that LINC01234 may represent a novel target for EC therapy. (Source: Cellular Oncology)
Source: Cellular Oncology - March 4, 2020 Category: Cancer & Oncology Source Type: research

The exosomal integrin α5β1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration
ConclusionsOur data indicate that EOCs may regulate the function of HPMCs through exosomal ITGA5B1/AEP, which may be crucial for peritoneal metastasis. (Source: Cellular Oncology)
Source: Cellular Oncology - February 21, 2020 Category: Cancer & Oncology Source Type: research