Correction to: Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
(Source: Cellular Oncology)
Source: Cellular Oncology - April 16, 2024 Category: Cancer & Oncology Source Type: research
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
ConclusionsThese data suggest that the presence of metastatic PDAC can be identified by integrating molecular compositions and drug responses of borderline resectable PDAC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
The emerging role of CARM1 in cancer
AbstractCoactivator-associated arginine methyltransferase 1 (CARM1), pivotal for catalyzing arginine methylation of histone and non-histone proteins, plays a crucial role in developing various cancers. CARM1 was initially recognized as a transcriptional coregulator by orchestrating chromatin remodeling, transcription regulation, mRNA splicing and stability. This diverse functionality contributes to the recruitment of transcription factors that foster malignancies. Going beyond its established involvement in transcriptional control, CARM1-mediated methylation influences a spectrum of biological processes, including the cell...
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Integrated analysis of single-cell RNA-seq and bulk RNA-seq reveals immune suppression subtypes and establishes a novel signature for determining the prognosis in lung adenocarcinoma
ConclusionsOur multi-omics result revealed a comprehensive set of molecular attributes associated with prognosis-related genes in LUAD at the cellular and tissue level. Identification of a subtype of immunosuppressive TME and prognostic signature for LUAD. We identified the cell cycle regulation geneCDC25C affects lung cancer cell invasion and migration, which can be used as a potential biomarker for LUAD. (Source: Cellular Oncology)
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Downregulation of GPX8 in hepatocellular carcinoma: impact on tumor stemness and migration
ConclusionThe findings from this study demonstrate the anticancer activity of GPX8 in HCC by inactivating the Hsc70/AKT pathway. The results suggest a possible therapeutic target for HCC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 12, 2024 Category: Cancer & Oncology Source Type: research
Dexmedetomidine promotes colorectal cancer progression via Piwil2 signaling
ConclusionDEX promotes CRC progression may via activating α2 adrenoceptor-dependent Nrf2/Piwil2/Siah2 pathway and thus EMT process. Our work provides a novel insight into the mechanism underlying tumor-promoting effects of α2-adrenoceptor agonists. (Source: Cellular Oncology)
Source: Cellular Oncology - April 9, 2024 Category: Cancer & Oncology Source Type: research
Hedgehog ligand and receptor cooperatively regulate EGFR stability and activity in non-small cell lung cancer
ConclusionNon-canonical Hh signaling pathway, involving cooperation between Hh ligands and their receptor Ptch1, facilitates the degradation of EGFR and attenuates its activity in NSCLC. These findings provide novel insights into the regulation of EGFR protein stability and activity, offer new diagnostic indicators for molecular typing of NSCLC and identify potential targets for targeted therapy of this challenging disease. (Source: Cellular Oncology)
Source: Cellular Oncology - April 3, 2024 Category: Cancer & Oncology Source Type: research
Efficacy of programmed cell death 1 inhibitor maintenance after chimeric antigen receptor T cells in patients with relapsed/refractory B-cell non-Hodgkin-lymphoma
ConclusionPD1 inhibitor maintenance following CD19/22 CAR-T therapy obtained superior response and survival in r/r B-NHL, but not in the trial of CD19/22 CAR-T cell therapy combined with ASCT. (Source: Cellular Oncology)
Source: Cellular Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
Copy number signatures and CCNE1 amplification reveal the involvement of replication stress in high-grade endometrial tumors oncogenesis
ConclusionThe identification ofCCNE1 amplification, which is currently being explored as a therapeutic target in clinical trials, suggests new treatment strategies for high-grade endometrial cancer. This finding holds particular significance for Martinique, where access to care is challenging. (Source: Cellular Oncology)
Source: Cellular Oncology - April 2, 2024 Category: Cancer & Oncology Source Type: research
IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/ β-catenin signaling
ConclusionsOur data indicate that IFIT1 increases pancreatic cancer cell proliferation, migration and invasion by activating the Wnt/ β-catenin pathway. In addition, we found that EMT could be regulated by IFIT1. IFIT1 may serve as a potential therapeutic target for pancreatic cancer. (Source: Cellular Oncology)
Source: Cellular Oncology - March 27, 2024 Category: Cancer & Oncology Source Type: research
DNA hypomethylation patterns and their impact on the tumor microenvironment in colorectal cancer
ConclusionThis study unveils a novel epigenetic phenotype in CRC linked to resistance against immune checkpoint inhibitors, presenting a significant step toward personalized medicine by suggesting epigenetic classifications as a means to identify ideal candidates for immunotherapy in CRC. Our findings also highlight potential therapeutic agents for the DMP subtype, offering new avenues for tailored CRC treatment strategies. (Source: Cellular Oncology)
Source: Cellular Oncology - March 23, 2024 Category: Cancer & Oncology Source Type: research
3D bioprinted tumor model: a prompt and convenient platform for overcoming immunotherapy resistance by recapitulating the tumor microenvironment
Conclusions and PerspectivesIn this review, we briefly summarize the contributions of cellular and noncellular components of the TME in the development of immunotherapy resistance, and introduce recent advances in 3D bioprinted tumor models that served as platforms to study the interactions between tumor cells and the TME. By constructing multicellular 3D bioprinted tumor models, cellular and noncellular crosstalk is reproduced between tumor cells, immune cells, fibroblasts, adipocytes, and the extracellular matrix (ECM) within the TME. In the future, by quickly preparing 3D bioprinted tumor models with patient-derived com...
Source: Cellular Oncology - March 23, 2024 Category: Cancer & Oncology Source Type: research
Multi-dimensional characterization of apoptosis in the tumor microenvironment and therapeutic relevance in melanoma
ConclusionOur findings indicate that ATM is a prognostic factor and is associated with the immune response and drug sensitivity in melanoma. (Source: Cellular Oncology)
Source: Cellular Oncology - March 19, 2024 Category: Cancer & Oncology Source Type: research
The Ribonuclease ZC3H12A is required for self-inflicted DNA breaks after DNA damage in small cell lung cancer cells
AbstractRadiotherapy is the first line treatment for small cell lung cancer (SCLC); However, radio-resistance accompanies with the treatment and hampers the prognosis for SCLC patients. The underlying mechanisms remains elusive. Here we discovered that self-inflicted DNA breaks exist in SCLC cells after radiation. Moreover, using nuclease siRNA screening combined with high-content ArrayScan ™ cell analyzer, we identified that Ribonuclease ZC3H12A is required for the self-inflicted DNA breaks after radiation and for SCLC cell survival after DNA damage. ZC3H12A expression was increased in response to DNA damage and when ZC...
Source: Cellular Oncology - March 18, 2024 Category: Cancer & Oncology Source Type: research
Mapping the immune terrain in lung adenocarcinoma progression: Tfh-like cells in tertiary lymphoid structures
(Source: Cellular Oncology)
Source: Cellular Oncology - March 16, 2024 Category: Cancer & Oncology Source Type: research
