Molecular characterization and clinical relevance of m6A regulators across 33 cancer types
The methylation of N6 adenosine (m6A) plays a critical role in diverse biological processes. However, knowledge regarding the reconstitution of m6A across cancer types is still lacking. Here, we systematically an... (Source: Molecular Cancer)
Source: Molecular Cancer - September 14, 2019 Category: Cancer & Oncology Authors: Yongsheng Li, Jun Xiao, Jing Bai, Yi Tian, Yinwei Qu, Xiang Chen, Qi Wang, Xinhui Li, Yunpeng Zhang and Juan Xu Tags: Letter to the Editor Source Type: research

Biogenesis, functions and clinical significance of circRNAs in gastric cancer
Gastric cancer (GC) is one of the most common malignant tumours in the world and has high morbidity and mortality. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently linked circular struct... (Source: Molecular Cancer)
Source: Molecular Cancer - September 13, 2019 Category: Cancer & Oncology Authors: Chan Shan, Yinfeng Zhang, Xiaodan Hao, Jinning Gao, Xinzhe Chen and Kun Wang Tags: Review Source Type: research

LncRNA SATB2-AS1 inhibits tumor metastasis and affects the tumor immune cell microenvironment in colorectal cancer by regulating SATB2
Emerging studies suggest that long non-coding RNAs (lncRNAs) play crucial roles in colorectal cancer (CRC). Here, we report a lncRNA, SATB2-AS1, which is specifically expressed in colorectal tissue and is sign... (Source: Molecular Cancer)
Source: Molecular Cancer - September 6, 2019 Category: Cancer & Oncology Authors: Mu Xu, Xueni Xu, Bei Pan, Xiaoxiang Chen, Kang Lin, Kaixuan Zeng, Xiangxiang Liu, Tao Xu, Li Sun, Jian Qin, Bangshun He, Yuqin Pan, Huiling Sun and Shukui Wang Tags: Research Source Type: research

RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma
Emerging evidences demonstrate that circular RNAs (circRNAs) are abnormally expressed in tumors and could serve as prognostic markers for cancers. However, the expression patterns and clinical implications of ... (Source: Molecular Cancer)
Source: Molecular Cancer - September 4, 2019 Category: Cancer & Oncology Authors: Chengdi Wang, Shuangyan Tan, Wen-Rong Liu, Qian Lei, Wenliang Qiao, Yangping Wu, Xiaoqi Liu, Wei Cheng, Yu-Quan Wei, Yong Peng and Weimin Li Tags: Letter to the Editor Source Type: research

Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence
Circular RNAs (circRNAs) represent a subclass of regulatory RNAs that have been shown to have significant regulatory roles in cancer progression. However, the biological functions of circRNAs in bladder cancer... (Source: Molecular Cancer)
Source: Molecular Cancer - September 3, 2019 Category: Cancer & Oncology Authors: Junming Bi, Hongwei Liu, Wei Dong, Weibin Xie, Qingqing He, Zijian Cai, Jian Huang and Tianxin Lin Tags: Research Source Type: research

Surgical stress and cancer progression: the twisted tango
Surgical resection is an important avenue for cancer treatment, which, in most cases, can effectively alleviate the patient symptoms. However, accumulating evidence has documented that surgical resection poten... (Source: Molecular Cancer)
Source: Molecular Cancer - September 2, 2019 Category: Cancer & Oncology Authors: Zhiwei Chen, Peidong Zhang, Ya Xu, Jiahui Yan, Zixuan Liu, Wayne Bond Lau, Bonnie Lau, Ying Li, Xia Zhao, Yuquan Wei and Shengtao Zhou Tags: Review Source Type: research

A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1
The RTK/PI3K/AKT pathway plays key roles in the development and progression of many cancers, including GBM. As a regulatory molecule and a potential drug target, the oncogenic role of AKT has been substantiall... (Source: Molecular Cancer)
Source: Molecular Cancer - August 30, 2019 Category: Cancer & Oncology Authors: Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang and Nu Zhang Tags: Research Source Type: research

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues the mortality rate of HCC rem... (Source: Molecular Cancer)
Source: Molecular Cancer - August 29, 2019 Category: Cancer & Oncology Authors: Chen Lu, Dawei Rong, Betty Zhang, Wubin Zheng, Xuehao Wang, Ziyi Chen and Weiwei Tang Tags: Review Source Type: research

Correction to: The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs
Following publication of the original article [1], authors reported Pro. Gang Zhao has to be considered as another corresponding author, according to his important contribution. (Source: Molecular Cancer)
Source: Molecular Cancer - August 27, 2019 Category: Cancer & Oncology Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao and Zi-Zhen Zhang Tags: Correction Source Type: research

Neoantigen vaccine: an emerging tumor immunotherapy
Genetic instability of tumor cells often leads to the occurrence of a large number of mutations, and expression of non-synonymous mutations can produce tumor-specific antigens called neoantigens. Neoantigens a... (Source: Molecular Cancer)
Source: Molecular Cancer - August 23, 2019 Category: Cancer & Oncology Authors: Miao Peng, Yongzhen Mo, Yian Wang, Pan Wu, Yijie Zhang, Fang Xiong, Can Guo, Xu Wu, Yong Li, Xiaoling Li, Guiyuan Li, Wei Xiong and Zhaoyang Zeng Tags: Review Source Type: research

Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis
Mounting evidences indicate that circular RNAs (circRNAs) play vital roles in the development and progression of various cancers. However, the detail functions and underlying mechanisms of circRNAs in gastric ... (Source: Molecular Cancer)
Source: Molecular Cancer - August 22, 2019 Category: Cancer & Oncology Authors: Zhonglin Zhu, Zeyin Rong, Zai Luo, Zhilong Yu, Jing Zhang, Zhengjun Qiu and Chen Huang Tags: Research Source Type: research

WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
N6-methyladenosine (m6A) methylation, a well-known modification with new epigenetic functions, has been reported to participate in the tumorigenesis of hepatocellular carcinoma (HCC), providing novel insights ... (Source: Molecular Cancer)
Source: Molecular Cancer - August 22, 2019 Category: Cancer & Oncology Authors: Yunhao Chen, Chuanhui Peng, Junru Chen, Diyu Chen, Beng Yang, Bin He, Wendi Hu, Yanpeng Zhang, Hua Liu, Longfei Dai, Haiyang Xie, Lin Zhou, Jian Wu and Shusen Zheng Tags: Research Source Type: research

Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity
Chimeric antigen receptor T (CAR-T) cell therapy is an emerging and effective cancer immunotherapy. Especially in hematological malignancies, CAR-T cells have achieved exciting results. Two Anti-CD19 CAR-T the... (Source: Molecular Cancer)
Source: Molecular Cancer - August 20, 2019 Category: Cancer & Oncology Authors: Shengnan Yu, Ming Yi, Shuang Qin and Kongming Wu Tags: Review Source Type: research

Exosomes promote pre-metastatic niche formation in ovarian cancer
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic gro... (Source: Molecular Cancer)
Source: Molecular Cancer - August 13, 2019 Category: Cancer & Oncology Authors: Wenlong Feng, Dylan C. Dean, Francis J. Hornicek, Huirong Shi and Zhenfeng Duan Tags: Review Source Type: research

The emerging role of the piRNA/piwi complex in cancer
Piwi interacting RNAs (piRNAs) constitute novel small non-coding RNA molecules of approximately 24 –31 nucleotides in length that often bind to members of the piwi protein family to play regulatory roles. Recen... (Source: Molecular Cancer)
Source: Molecular Cancer - August 9, 2019 Category: Cancer & Oncology Authors: Yongmei Liu, Mei Dou, Xuxia Song, Yanhan Dong, Si Liu, Haoran Liu, Jiaping Tao, Wenjing Li, Xunhua Yin and Wenhua Xu Tags: Review Source Type: research

Correction to: MicroRNA-30d promotes angiogenesis and tumor growth via MYPT1/c-JUN/VEGFA pathway and predicts aggressive outcome in prostate cancer
After publication of the article [1], the author reported that this article contained some errors. (Source: Molecular Cancer)
Source: Molecular Cancer - August 6, 2019 Category: Cancer & Oncology Authors: Zhuo-yuan Lin, Guo Chen, Yan-qiong Zhang, Hui-chan He, Yu-xiang Liang, Jian-heng Ye, Ying-ke Liang, Ru-jun Mo, Jian-ming Lu, Yang-jia Zhuo, Yu Zheng, Fu-neng Jiang, Zhao-dong Han, Shu-lin Wu, Wei-de Zhong and Chin-Lee Wu Tags: Correction Source Type: research

Correction to: Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis
After publication of the article [1], the author reported that this article contained error. In Funding section, the funding number provided 2016YFC0105100 should have been 2016YFC0105106. (Source: Molecular Cancer)
Source: Molecular Cancer - August 5, 2019 Category: Cancer & Oncology Authors: Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang and Baosheng Li Tags: Correction Source Type: research

The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma
Bone metastasis (BM) has long been recognized as a major threat to the quality of life of hepatocellular cancer (HCC) patients. While LncRNA34a (Lnc34a) has been shown to regulate colon cancer stem cell asymme... (Source: Molecular Cancer)
Source: Molecular Cancer - July 26, 2019 Category: Cancer & Oncology Authors: Li Zhang, Hao Niu, Jie Ma, Bao-Ying Yuan, Yu-Han Chen, Yuan Zhuang, Gen-Wen Chen, Zhao-Chong Zeng and Zuo-Lin Xiang Tags: Research Source Type: research

Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression
Increasing evidence has revealed a close relationship between non-coding RNAs and cancer progression. Circular RNAs (circRNAs), a recently identified new member of non-coding RNAs, are demonstrated to particip... (Source: Molecular Cancer)
Source: Molecular Cancer - July 19, 2019 Category: Cancer & Oncology Authors: Liyan Wang, Haiyan Long, Qinghua Zheng, Xiaotong Bo, Xuhua Xiao and Bin Li Tags: Research Source Type: research

Retraction Note: miR-663 attenuates tumor growth and invasiveness by targeting eEF1A2 in pancreatic cancer
The Editor-in-Chief has retracted this article [1] because Figure 6b overlaps with Figure 8 of [2] and Figure 4a overlaps with Figure 2b of [3] (Source: Molecular Cancer)
Source: Molecular Cancer - July 18, 2019 Category: Cancer & Oncology Authors: Wenqiao Zang, Yuanyuan Wang, Tao Wang, Yuwen Du, Xiaonan Chen, Min Li and Guoqiang Zhao Tags: Retraction Note Source Type: research

Correction to: Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis
After the publication of this work [1], a spelling error was found: the ID of the circRNA, termed circYAP1, in the original publication was misspelled as “has_circ_0002320”. (Source: Molecular Cancer)
Source: Molecular Cancer - July 9, 2019 Category: Cancer & Oncology Authors: Hui Liu, Yuan Liu, Zhaolian Bian, Jing Zhang, Rui Zhang, Xiaoyu Chen, Yanxia Huang, Yang Wang and Jinshui Zhu Tags: Correction Source Type: research

Exosomal circRNAs: biogenesis, effect and application in human diseases
Exosomes have emerged as critical mediators of intercellular communication, both locally and systemically, by regulating a diverse range of biological processes between cells. Circular RNA (circRNA) is a novel... (Source: Molecular Cancer)
Source: Molecular Cancer - July 5, 2019 Category: Cancer & Oncology Authors: Yangxia Wang, Jinbo Liu, Junfen Ma, Ting Sun, Quanbo Zhou, Weiwei Wang, Guixian Wang, Pingjun Wu, Haijiang Wang, Li Jiang, Weitang Yuan, Zhenqiang Sun and Liang Ming Tags: Review Source Type: research

The lncRNA UCA1 promotes proliferation, migration, immune escape and inhibits apoptosis in gastric cancer by sponging anti-tumor miRNAs
UCA1 is a long non-coding RNA which was found overexpressed in various human cancers including gastric cancer (GC). It is identified that UCA1 promotes GC cells proliferation, migration and invasion, however, ... (Source: Molecular Cancer)
Source: Molecular Cancer - July 4, 2019 Category: Cancer & Oncology Authors: Chao-Jie Wang, Chun-Chao Zhu, Jia Xu, Ming Wang, Wen-Yi Zhao, Qiang Liu, Gang Zhao and Zi-Zhen Zhang Tags: Research Source Type: research

Liquid biopsy in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
Hepatocellular carcinoma (HCC) is one of the most common cancers and a leading cause of death worldwide. Due to latent liver disease, late diagnosis, and nonresponse to systemic treatments, surgical resection ... (Source: Molecular Cancer)
Source: Molecular Cancer - July 3, 2019 Category: Cancer & Oncology Authors: Qianwei Ye, Sunbin Ling, Shusen Zheng and Xiao Xu Tags: Review Source Type: research

Discovery of a novel long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth
Virtually all patients with metastatic prostate cancer (PCa) will relapse and develop lethal castration-resistant prostate cancer (CRPC). Long noncoding RNAs (lncRNAs) are emerging as critical regulatory eleme... (Source: Molecular Cancer)
Source: Molecular Cancer - June 28, 2019 Category: Cancer & Oncology Authors: Huy Q. Ta, Hilary Whitworth, Yi Yin, Mark Conaway, Henry F. Frierson Jr, Moray J. Campbell, Ganesh V. Raj and Daniel Gioeli Tags: Research Source Type: research

METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinoma
Colorectal carcinoma (CRC) is one of the most common malignant tumors, and its main cause of death is tumor metastasis. RNA N6-methyladenosine (m6A) is an emerging regulatory mechanism for gene expression and met... (Source: Molecular Cancer)
Source: Molecular Cancer - June 24, 2019 Category: Cancer & Oncology Authors: Ting Li, Pei-Shan Hu, Zhixiang Zuo, Jin-Fei Lin, Xingyang Li, Qi-Nian Wu, Zhan-Hong Chen, Zhao-Lei Zeng, Feng Wang, Jian Zheng, Demeng Chen, Bo Li, Tie-Bang Kang, Dan Xie, Dongxin Lin, Huai-Qiang Ju & hellip; Tags: Research Source Type: research

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner
METTL3 is known to be involved in all stages in the life cycle of RNA. It affects the tumor formation by the regulation the m6A modification in the mRNAs of critical oncogenes or tumor suppressors. In bladder ... (Source: Molecular Cancer)
Source: Molecular Cancer - June 22, 2019 Category: Cancer & Oncology Authors: Jie Han, Jing-zi Wang, Xiao Yang, Hao Yu, Rui Zhou, Hong-Cheng Lu, Wen-Bo Yuan, Jian-chen Lu, Zi-jian Zhou, Qiang Lu, Ji-Fu Wei and Haiwei Yang Tags: Research Source Type: research

Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN
Circular RNAs (circRNAs) are a novel class of endogenous noncoding RNAs formed by a covalently closed loop, and increasing evidence has revealed that circRNAs play crucial functions in regulating gene expressi... (Source: Molecular Cancer)
Source: Molecular Cancer - June 22, 2019 Category: Cancer & Oncology Authors: Qun Lu, Tianyao Liu, Huijin Feng, Rong Yang, Xiaozhi Zhao, Wei Chen, Bo Jiang, Haixiang Qin, Xu Guo, Minghui Liu, Limin Li and Hongqian Guo Tags: Research Source Type: research

Lung adenocarcinoma-intrinsic GBE1 signaling inhibits anti-tumor immunity
Changes in glycogen metabolism is an essential feature among the various metabolic adaptations used by cancer cells to adjust to the conditions imposed by the tumor microenvironment. Our previous study showed ... (Source: Molecular Cancer)
Source: Molecular Cancer - June 20, 2019 Category: Cancer & Oncology Authors: Lifeng Li, Li Yang, Shiqi Cheng, Zhirui Fan, Zhibo Shen, Wenhua Xue, Yujia Zheng, Feng Li, Dong Wang, Kai Zhang, Jingyao Lian, Dan Wang, Zijia Zhu, Jie Zhao and Yi Zhang Tags: Research Source Type: research

A novel AR translational regulator lncRNA LBCS inhibits castration resistance of prostate cancer
Progression to a castration resistance state is the main cause of deaths in prostate cancer (PCa) patients. Androgen Receptor (AR) signaling plays the central role in progression of Castration Resistant Prosta... (Source: Molecular Cancer)
Source: Molecular Cancer - June 20, 2019 Category: Cancer & Oncology Authors: Peng Gu, Xu Chen, Ruihui Xie, Weibin Xie, Li Huang, Wen Dong, Jinli Han, Xiaodong Liu, Jihong Shen, Jian Huang and Tianxin Lin Tags: Research Source Type: research

Correction to: N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ ATM pathway
Following publication of the original article [1], the authors reported that name that appeared in published online version is incorrect. Aifeng Wang should be Aifen Wang. Corrected name is provided in the aut... (Source: Molecular Cancer)
Source: Molecular Cancer - June 19, 2019 Category: Cancer & Oncology Authors: Yu Yin, Lingfan Xu, Yan Chang, Tao Zeng, Xufeng Chen, Aifen Wang, Jeff Groth, Wen-Chi Foo, Chaozhao Liang, Hailiang Hu and Jiaoti Huang Tags: Correction Source Type: research

Pan-cancer analysis identifies telomerase-associated signatures and cancer subtypes
Cancer cells become immortalized through telomere maintenance mechanisms, such as telomerase reverse transcriptase (TERT) activation. In addition to maintaining telomere length, TERT activates manifold cell su... (Source: Molecular Cancer)
Source: Molecular Cancer - June 10, 2019 Category: Cancer & Oncology Authors: Zhenhua Luo, Weixu Wang, Feng Li, Zhou Songyang, Xuyang Feng, Changchang Xin, Zhiming Dai and Yuanyan Xiong Tags: Research Source Type: research

Retraction Note: Upregulation of the long non-coding RNA AFAP1-AS1 affects the proliferation, invasion and survival of tongue squamous cell carcinoma via the Wnt/ β-catenin signaling pathway
The authors have retracted this article [1] because there are errors in Figures 4a and 4b (Source: Molecular Cancer)
Source: Molecular Cancer - June 1, 2019 Category: Cancer & Oncology Authors: Ze-you Wang, Min Hu, Min-hui Dai, Jing Xiong, Shuai Zhang, Han-jiang Wu, Shan-shan Zhang and Zhao-jian Gong Tags: Retraction Note Source Type: research

Circular RNA circTRIM33 –12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression
Recently, the dysregulation of circular RNA (circRNA) have been shown to have important regulatory roles in cancer development and progression, including hepatocellular carcinoma (HCC). However, the roles of m... (Source: Molecular Cancer)
Source: Molecular Cancer - June 1, 2019 Category: Cancer & Oncology Authors: Peng-Fei Zhang, Chuan-Yuan Wei, Xiao-Yong Huang, Rui Peng, Xuan Yang, Jia-Cheng Lu, Chi Zhang, Chao Gao, Jia-Bin Cai, Ping-Ting Gao, Dong-Mei Gao, Guo-Ming Shi, Ai-Wu Ke and Jia Fan Tags: Research Source Type: research

The role of m6A RNA methylation in human cancer
N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs). M6A modification is installed by the m (Source: Molecular Cancer)
Source: Molecular Cancer - May 29, 2019 Category: Cancer & Oncology Authors: Xiao-Yu Chen, Jing Zhang and Jin-Shui Zhu Tags: Review Source Type: research

Long non-coding RNAs in Oral squamous cell carcinoma: biologic function, mechanisms and clinical implications
There is growing evidence that regions of the genome that cannot encode proteins play an important role in diseases. These regions are usually transcribed into long non-coding RNAs (lncRNAs). LncRNAs, little o... (Source: Molecular Cancer)
Source: Molecular Cancer - May 27, 2019 Category: Cancer & Oncology Authors: Lei Zhang, Xiang Meng, Xin-wei Zhu, Deng-cheng Yang, Ran Chen, Yong Jiang and Tao Xu Tags: Review Source Type: research

Crosstalk between autophagy and epithelial-mesenchymal transition and its application in cancer therapy
Autophagy is a highly conserved catabolic process that mediates degradation of pernicious or dysfunctional cellular components, such as invasive pathogens, senescent proteins, and organelles. It can promote or... (Source: Molecular Cancer)
Source: Molecular Cancer - May 24, 2019 Category: Cancer & Oncology Authors: Hong-Tao Chen, Hao Liu, Min-Jie Mao, Yuan Tan, Xiang-Qiong Mo, Xiao-Jun Meng, Meng-Ting Cao, Chu-Yu Zhong, Yan Liu, Hong Shan and Guan-Min Jiang Tags: Review Source Type: research

miR-301a promotes lung tumorigenesis by suppressing Runx3
Our previous report demonstrated that genetic ablation of miR-301a reduces Kras-driven lung tumorigenesis in mice. However, the impact of miR-301a on host anti-tumor immunity remains unexplored. Here we assessed ... (Source: Molecular Cancer)
Source: Molecular Cancer - May 23, 2019 Category: Cancer & Oncology Authors: Xun Li, Mingtian Zhong, Jiexuan Wang, Lei Wang, Zhanwen Lin, Zhi Cao, Zhujuan Huang, Fengxue Zhang, Yong Li, Ming Liu and Xiaodong Ma Tags: Research Source Type: research

The role of necroptosis in cancer biology and therapy
Apoptosis resistance is to a large extent a major obstacle leading to chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway to induce cancer cell death is considered to be a promising a... (Source: Molecular Cancer)
Source: Molecular Cancer - May 23, 2019 Category: Cancer & Oncology Authors: Yitao Gong, Zhiyao Fan, Guopei Luo, Chao Yang, Qiuyi Huang, Kun Fan, He Cheng, Kaizhou Jin, Quanxing Ni, Xianjun Yu and Chen Liu Tags: Review Source Type: research

Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer
Cancer-associated chromosomal translocations are reported to generate oncogenic circular RNA (circRNA), contributing to tumorigenesis. The fusion gene SLC34A2-ROS1 (solute carrier family 34 member 2 and ROS proto... (Source: Molecular Cancer)
Source: Molecular Cancer - May 22, 2019 Category: Cancer & Oncology Authors: Ke Wu, Xun Liao, Youling Gong, Juan He, Jian-Kang Zhou, Shuangyan Tan, Wenchen Pu, Canhua Huang, Yu-Quan Wei and Yong Peng Tags: Letter to the Editor Source Type: research

Loss of the transcriptional repressor TGIF1 results in enhanced Kras-driven development of pancreatic cancer
The TG-interacting factor 1 (TGIF1) gene, which encodes a nuclear transcriptional corepressor of the TGF β1/Smad signaling pathway, has been implicated in the pathogenesis of various types of human cancer; howe... (Source: Molecular Cancer)
Source: Molecular Cancer - May 20, 2019 Category: Cancer & Oncology Authors: Ching-Chieh Weng, Mei-Jen Hsieh, Chia-Chen Wu, Yu-Chun Lin, Yan-Shen Shan, Wen-Chun Hung, Li-Tzong Chen and Kuang-Hung Cheng Tags: Research Source Type: research

The microbiota and microbiome in pancreatic cancer: more influential than expected
Microbiota is just beginning to be recognized as an important player in carcinogenesis and the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal dise... (Source: Molecular Cancer)
Source: Molecular Cancer - May 20, 2019 Category: Cancer & Oncology Authors: Miao-Yan Wei, Si Shi, Chen Liang, Qing-Cai Meng, Jie Hua, Yi-Yin Zhang, Jiang Liu, Bo Zhang, Jin Xu and Xian-Jun Yu Tags: Review Source Type: research

Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis
Circular RNAs (circRNAs) have been considered to mediate occurrence and development of human cancers, generally acting as microRNA (miRNA) sponges to regulate downstream genes expression. However, the aberrant... (Source: Molecular Cancer)
Source: Molecular Cancer - May 17, 2019 Category: Cancer & Oncology Authors: Wei Dong, Junming Bi, Hongwei Liu, Dong Yan, Qingqing He, Qianghua Zhou, Qiong Wang, Ruihui Xie, Yinjie Su, Meihua Yang, Tianxin Lin and Jian Huang Tags: Research Source Type: research

Targeting Tyro3, Axl and MerTK (TAM receptors): implications for macrophages in the tumor microenvironment
Tumor-associated macrophages are an abundant cell type in the tumor microenvironment. These macrophages serve as a promising target for treatment of cancer due to their roles in promoting cancer progression an... (Source: Molecular Cancer)
Source: Molecular Cancer - May 14, 2019 Category: Cancer & Oncology Authors: Kayla V. Myers, Sarah R. Amend and Kenneth J. Pienta Tags: Review Source Type: research

Function and clinical relevance of RHAMM isoforms in pancreatic tumor progression
The receptor for hyaluronic acid-mediated motility (RHAMM) is upregulated in various cancers. We previously screened genes upregulated in human hepatocellular carcinomas for their metastatic function in a mous... (Source: Molecular Cancer)
Source: Molecular Cancer - May 9, 2019 Category: Cancer & Oncology Authors: Soyoung Choi, Dunrui Wang, Xiang Chen, Laura H. Tang, Akanksha Verma, Zhengming Chen, Bu Jung Kim, Leigh Selesner, Kenneth Robzyk, George Zhang, Sharon Pang, Teng Han, Chang S. Chan, Thomas J. Fahey III, Olivier Elemento and Yi-Chieh Nancy Du Tags: Letter to the Editor Source Type: research

MED12 exerts an emerging role in actin-mediated cytokinesis via LIMK2/cofilin pathway in NSCLC
Mediator complex subunit 12 (MED12) is an essential hub for transcriptional regulation, in which mutations and overexpression were reported to be associated with several kinds of malignancies. Nevertheless, th... (Source: Molecular Cancer)
Source: Molecular Cancer - May 9, 2019 Category: Cancer & Oncology Authors: Meng Xu, Fang Wang, Guibo Li, Xiaokun Wang, Xiaona Fang, Haoxuan Jin, Zhen Chen, Jianye Zhang and Liwu Fu Tags: Research Source Type: research

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer
Cancer associated fibroblasts (CAFs) are key stroma cells that play dominant roles in tumor progression. However, the CAFs-derived molecular determinants that regulate colorectal cancer (CRC) metastasis and ch... (Source: Molecular Cancer)
Source: Molecular Cancer - May 7, 2019 Category: Cancer & Oncology Authors: J. L. Hu, W. Wang, X. L. Lan, Z. C. Zeng, Y. S. Liang, Y. R. Yan, F. Y. Song, F. F. Wang, X. H. Zhu, W. J. Liao, W. T. Liao, Y. Q. Ding and L. Liang Tags: Research Source Type: research

Ai-lncRNA EGOT enhancing autophagy sensitizes paclitaxel cytotoxicity via upregulation of ITPR1 expression by RNA-RNA and RNA-protein interactions in human cancer
The biology function of antisense intronic long noncoding RNA (Ai-lncRNA) is still unknown. Meanwhile, cancer patients with paclitaxel resistance have limited therapeutic options in the clinic. However, the po... (Source: Molecular Cancer)
Source: Molecular Cancer - April 18, 2019 Category: Cancer & Oncology Authors: Shouping Xu, Peiyuan Wang, Jian Zhang, Hao Wu, Shiyao Sui, Jinfeng Zhang, Qin Wang, Kun Qiao, Weiwei Yang, Hongbiao Xu and Da Pang Tags: Research Source Type: research

Circular RNAs in Cancer: emerging functions in hallmarks, stemness, resistance and roles as potential biomarkers
Circular RNAs (circRNAs) are a class of RNA molecules with closed loops and high stability. CircRNAs are abundantly expressed in eukaryotic organisms and exhibit both location- and step-specificity. In recent ... (Source: Molecular Cancer)
Source: Molecular Cancer - April 18, 2019 Category: Cancer & Oncology Authors: Min Su, Yuhang Xiao, Junliang Ma, Yanyan Tang, Bo Tian, Yuqin Zhang, Xu Li, Zhining Wu, Desong Yang, Yong Zhou, Hui Wang, Qianjin Liao and Wenxiang Wang Tags: Review Source Type: research

m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1
Long noncoding RNAs (lncRNAs) have emerged as critical players in cancer progression, but their functions in colorectal cancer (CRC) metastasis have not been systematically clarified. (Source: Molecular Cancer)
Source: Molecular Cancer - April 13, 2019 Category: Cancer & Oncology Authors: Yingmin Wu, Xiangling Yang, Zhuojia Chen, Lin Tian, Guanmin Jiang, Feng Chen, Jiexin Li, Panpan An, Linlin Lu, Nan Luo, Jun Du, Hong Shan, Huanliang Liu and Hongsheng Wang Tags: Research Source Type: research