m6A modification-mediated BATF2 acts as a tumor suppressor in gastric cancer through inhibition of ERK signaling
BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance in human gastric cancer (GC) are elusive. (Source: Molecular Cancer)
Source: Molecular Cancer - July 10, 2020 Category: Cancer & Oncology Authors: Jian-Wei Xie, Xiao-Bo Huang, Qi-Yue Chen, Yu-Bin Ma, Ya-Jun Zhao, Li-Chao Liu, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Long-Long Cao, Mi Lin, Ru-Hong Tu, Chao-Hui Zheng, Chang-Ming Huang and Ping Li Tags: Research Source Type: research

Correction to: Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Cancer)
Source: Molecular Cancer - July 2, 2020 Category: Cancer & Oncology Authors: Liyuan Fan, Qiang Cao, Jia Liu, Junpeng Zhang and Baosheng Li Tags: Correction Source Type: research

Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation
Circular RNAs (circRNAs) play important regulatory roles in the development of various cancers. However, biological functions and the underlying molecular mechanism of circRNAs in gastric cancer (GC) remain ob... (Source: Molecular Cancer)
Source: Molecular Cancer - June 29, 2020 Category: Cancer & Oncology Authors: Mengyan Xie, Tao Yu, Xinming Jing, Ling Ma, Yu Fan, Fengming Yang, Pei Ma, Huning Jiang, Xi Wu, Yongqian Shu and Tongpeng Xu Tags: Research Source Type: research

Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma
Natural killer (NK) cells play a critical role in the innate antitumor immune response. Recently, NK cell dysfunction has been verified in various malignant tumors, including hepatocellular carcinoma (HCC). Ho... (Source: Molecular Cancer)
Source: Molecular Cancer - June 27, 2020 Category: Cancer & Oncology Authors: Peng-Fei Zhang, Chao Gao, Xiao-Yong Huang, Jia-Cheng Lu, Xiao-Jun Guo, Guo-Ming Shi, Jia-Bin Cai and Ai-Wu Ke Tags: Research Source Type: research

Correction to: microRNA-124 inhibits bone metastasis of breast cancer by repressing Interleukin-11
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Cancer)
Source: Molecular Cancer - June 27, 2020 Category: Cancer & Oncology Authors: Wei-Luo Cai, Wen-Ding Huang, Bo Li, Tian-Rui Chen, Zhen-Xi Li, Cheng-Long Zhao, Heng-Yu Li, Yan-Mei Wu, Wang-Jun Yan and Jian-Ru Xiao Tags: Correction Source Type: research

Bmi-1-induced miR-27a and miR-155 promote tumor metastasis and chemoresistance by targeting RKIP in gastric cancer
We previously reported an inverse relationship between B cell-specific Moloney murine leukemia virus integration site 1 (Bmi-1) and Raf kinase inhibitory protein (RKIP), which is associated with the prognosis ... (Source: Molecular Cancer)
Source: Molecular Cancer - June 24, 2020 Category: Cancer & Oncology Authors: Yaqing Li, Zhenfeng Tian, Ying Tan, Guoda Lian, Shangxiang Chen, Shaojie Chen, Jiajia Li, Xuanna Li, Kaihong Huang and Yinting Chen Tags: Research Source Type: research

The genetic and pharmacogenomic landscape of snoRNAs in human cancer
Emerging evidence has revealed significant roles for small nucleolar RNAs (snoRNAs) in tumorigenesis. However, the genetic and pharmacogenomic landscape of snoRNAs has not been characterized. Using the genotyp... (Source: Molecular Cancer)
Source: Molecular Cancer - June 23, 2020 Category: Cancer & Oncology Authors: Yaoming Liu, Hang Ruan, Shengli Li, Youqiong Ye, Wei Hong, Jing Gong, Zhao Zhang, Ying Jing, Xiulan Zhang, Lixia Diao and Leng Han Tags: Letter to the Editor Source Type: research

PARP inhibitor resistance: the underlying mechanisms and clinical implications
Due to the DNA repair defect, BRCA1/2 deficient tumor cells are more sensitive to PARP inhibitors (PARPi) through the mechanism of synthetic lethality. At present, several PAPRi targeting poly (ADP-ribose) pol... (Source: Molecular Cancer)
Source: Molecular Cancer - June 20, 2020 Category: Cancer & Oncology Authors: He Li, Zhao-Yi Liu, Nayiyuan Wu, Yong-Chang Chen, Quan Cheng and Jing Wang Tags: Review Source Type: research

METTL14-mediated N6-methyladenosine modification of SOX4 mRNA inhibits tumor metastasis in colorectal cancer
Colorectal cancer (CRC) is one of the leading causes of tumor-related death worldwide, and its main cause of death is distant metastasis. Methyltransferase-like 14(METTL14), a major RNA N6-adenosine methyltran... (Source: Molecular Cancer)
Source: Molecular Cancer - June 17, 2020 Category: Cancer & Oncology Authors: Xiaoxiang Chen, Mu Xu, Xueni Xu, Kaixuan Zeng, Xiangxiang Liu, Bei Pan, Chenmeng Li, Li Sun, Jian Qin, Tao Xu, Bangshun He, Yuqin Pan, Huilin Sun and Shukui Wang Tags: Research Source Type: research

The role of N6-methyladenosine (m6A) modification in the regulation of circRNAs
N6-methyladenosine (m6A), the most abundant modification in eukaryotic cells, regulates RNA transcription, processing, splicing, degradation, and translation. Circular RNA (circRNA) is a class of covalently close... (Source: Molecular Cancer)
Source: Molecular Cancer - June 10, 2020 Category: Cancer & Oncology Authors: Lele Zhang, Chaofeng Hou, Chen Chen, Yaxin Guo, Weitang Yuan, Detao Yin, Jinbo Liu and Zhenqiang Sun Tags: Review Source Type: research

Mechanism of RNA modification N6-methyladenosine in human cancer
Since the breakthrough discoveries of DNA and histone modifications, the field of RNA modifications has gained increasing interest in the scientific community. The discovery of N6-methyladenosine (m6A), a pred... (Source: Molecular Cancer)
Source: Molecular Cancer - June 8, 2020 Category: Cancer & Oncology Authors: Zijian Zhou, Jiancheng Lv, Hao Yu, Jie Han, Xiao Yang, Dexiang Feng, Qikai Wu, Baorui Yuan, Qiang Lu and Haiwei Yang Tags: Review Source Type: research

Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology
Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane,... (Source: Molecular Cancer)
Source: Molecular Cancer - June 5, 2020 Category: Cancer & Oncology Authors: Wei Hu, Cong Liu, Zhuo-Yue Bi, Qun Zhou, Han Zhang, Lin-Lin Li, Jian Zhang, Wei Zhu, Yang-Yi-Yan Song, Feng Zhang, Hui-Min Yang, Yong-Yi Bi, Qi-Qiang He, Gong-Jun Tan, Cheng-Cao Sun and De-Jia Li Tags: Review Source Type: research

CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p
Circular RNAs (circRNAs), a novel type of noncoding RNA (ncRNA), are covalently linked circular configurations that form via a loop structure. Accumulating evidence indicates that circRNAs are potential biomar... (Source: Molecular Cancer)
Source: Molecular Cancer - June 5, 2020 Category: Cancer & Oncology Authors: Jianfa Li, Chenchen Huang, Yifan Zou, Jing Ye, Jing Yu and Yaoting Gui Tags: Research Source Type: research

Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells
Lung cancer has high morbidity and mortality worldwide with non-small cell lung cancer (NSCLC) accounting for 85% of the cases. Therapies for lung cancer have relatively poor outcomes and further improvements ... (Source: Molecular Cancer)
Source: Molecular Cancer - June 3, 2020 Category: Cancer & Oncology Authors: Nan Zhang, Aruo Nan, Lijian Chen, Xin Li, Yangyang Jia, Miaoyun Qiu, Xin Dai, Hanyu Zhou, Jialu Zhu, Han Zhang and Yiguo Jiang Tags: Research Source Type: research

Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor of the head and neck. LSCC patients have seriously impaired vocal, respiratory, and swallowing functions with poor prognosis. Circular RNA (... (Source: Molecular Cancer)
Source: Molecular Cancer - June 2, 2020 Category: Cancer & Oncology Authors: Yongyan Wu, Yuliang Zhang, Xiwang Zheng, Fengsheng Dai, Yan Lu, Li Dai, Min Niu, Huina Guo, Wenqi Li, Xuting Xue, Yunfeng Bo, Yujia Guo, Jiangbo Qin, Yixiao Qin, Hongliang Liu, Yu Zhang & hellip; Tags: Research Source Type: research

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a review
In recent years, the prevalence and spread of coronavirus has had a huge impact on global public health. Due to the incomplete understanding of the pathogenic mechanism of the virus, it is difficult for humans... (Source: Molecular Cancer)
Source: Molecular Cancer - June 2, 2020 Category: Cancer & Oncology Authors: Wei Feng, Wei Zong, Feng Wang and Shaoqing Ju Tags: Review Source Type: research

Correction to: Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating acrophages with alteration of the TIMP-1/MMP2/MMP9 signals
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Cancer)
Source: Molecular Cancer - May 30, 2020 Category: Cancer & Oncology Authors: Xianfan Ding, Dong-Rong Yang, Liqun Xia, Bide Chen, Shicheng Yu, Yuanjie Niu, Mingchao Wang, Gonghui Li and Chawnshang Chang Tags: Correction Source Type: research

LINC00173.v1 promotes angiogenesis and progression of lung squamous cell carcinoma by sponging miR-511-5p to regulate VEGFA expression
Anti-angiogenic therapy represents a promising strategy for non-small-cell lung cancer (NSCLC) but its application in lung squamous cell carcinoma (SQC) is limited due to the high-risk adverse effects. Accumul... (Source: Molecular Cancer)
Source: Molecular Cancer - May 30, 2020 Category: Cancer & Oncology Authors: Jiarong Chen, Aibin Liu, Zhihui Wang, Bin Wang, Xingxing Chai, Wenjie Lu, Ting Cao, Ronggang Li, Minyan Wu, Zhuming Lu, Wenguang Pang, Lin Xiao, Xiangmeng Chen, Yan Zheng, Qiong Chen, Jincheng Zeng & hellip; Tags: Research Source Type: research

Long non-coding RNAs towards precision medicine in gastric cancer: early diagnosis, treatment, and drug resistance
Gastric cancer is a deadly disease and remains the third leading cause of cancer-related death worldwide. The 5-year overall survival rate of patients with early-stage localized gastric cancer is more than 60%... (Source: Molecular Cancer)
Source: Molecular Cancer - May 27, 2020 Category: Cancer & Oncology Authors: Li Yuan, Zhi-Yuan Xu, Shan-Ming Ruan, Shaowei Mo, Jiang-Jiang Qin and Xiang-Dong Cheng Tags: Review Source Type: research

Interaction between N6-methyladenosine (m6A) modification and noncoding RNAs in cancer
As a critical internal RNA modification in higher eukaryotes, N6-methyladenosine (m6A) has become the hotspot of epigenetics research in recent years. Extensive studies on messenger RNAs have revealed that m6A af... (Source: Molecular Cancer)
Source: Molecular Cancer - May 22, 2020 Category: Cancer & Oncology Authors: Yi Chen, Yu Lin, Yongqian Shu, Jing He and Wen Gao Tags: Review Source Type: research

Long noncoding RNA ZFAS1 promoting small nucleolar RNA-mediated 2 ′-O-methylation via NOP58 recruitment in colorectal cancer
Increasing evidence supports the role of small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs) as master gene regulators at the epigenetic modification level. However, the underlying mechanism of t... (Source: Molecular Cancer)
Source: Molecular Cancer - May 22, 2020 Category: Cancer & Oncology Authors: Huizhe Wu, Wenyan Qin, Senxu Lu, Xiufang Wang, Jing Zhang, Tong Sun, Xiaoyun Hu, Yalun Li, Qiuchen Chen, Yuanhe Wang, Haishan Zhao, Haiyan Piao, Rui Zhang and Minjie Wei Tags: Research Source Type: research

Correction to: Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Cancer)
Source: Molecular Cancer - May 20, 2020 Category: Cancer & Oncology Authors: Ke Xu, Dongkyoo Park, Andrew T. Magis, Jun Zhang, Wei Zhou, Gabriel L. Sica, Suresh S. Ramalingam, Walter J. Curran and Xingming Deng Tags: Correction Source Type: research

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
This study aimed to explore the role of the m6A demethylase ALK... (Source: Molecular Cancer)
Source: Molecular Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Xingya Guo, Kai Li, Weiliang Jiang, Yangyang Hu, Wenqin Xiao, Yinshi Huang, Yun Feng, Qin Pan and Rong Wan Tags: Research Source Type: research

Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis
Amplification of chromosome 7q21-7q31 is associated with tumor recurrence and multidrug resistance, and several genes in this region are powerful drivers of hepatocellular carcinoma (HCC). We aimed to investig... (Source: Molecular Cancer)
Source: Molecular Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Xiao-Yong Huang, Peng-Fei Zhang, Chuan-Yuan Wei, Rui Peng, Jia-Cheng Lu, Chao Gao, Jia-Bing Cai, Xuan Yang, Jia Fan, Ai-Wu Ke, Jian Zhou and Guo-Ming Shi Tags: Research Source Type: research

Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance
Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation EGFR inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven b... (Source: Molecular Cancer)
Source: Molecular Cancer - May 13, 2020 Category: Cancer & Oncology Authors: Tao Zhang, Rong Qu, Shingpan Chan, Mengzhen Lai, Linjiang Tong, Fang Feng, Hongyu Chen, Tingting Song, Peiran Song, Gang Bai, Yingqiang Liu, Yanan Wang, Yan Li, Yi Su, Yanyan Shen, Yiming Sun & hellip; Tags: Research Source Type: research

The potential role of RNA N6-methyladenosine in Cancer progression
N6-methyladenosine (m6A) is considered the most common, abundant, and conserved internal transcript modification, especially in eukaryotic messenger RNA (mRNA). m6A is installed by m6A methyltransferases (METT... (Source: Molecular Cancer)
Source: Molecular Cancer - May 12, 2020 Category: Cancer & Oncology Authors: Tianyi Wang, Shan Kong, Mei Tao and Shaoqing Ju Tags: Review Source Type: research

Correction to: Exosome-transmitted miR-128-3p increase chemosensitivity of oxaliplatin-resistant colorectal cancer
An amendment to this paper has been published and can be accessed via the original article. (Source: Molecular Cancer)
Source: Molecular Cancer - May 12, 2020 Category: Cancer & Oncology Authors: Tong Liu, Xin Zhang, Lutao Du, Yunshan Wang, Xiaoming Liu, Hui Tian, Lili Wang, Peilong Li, Yinghui Zhao, Weili Duan, Yujiao Xie, Zhaowei Sun and Chuanxin Wang Tags: Correction Source Type: research

LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer
Estrogen receptor-positive (ER+) breast cancers represent approximately two-thirds of all breast cancers and have a sustained risk of late disease recurrence. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor... (Source: Molecular Cancer)
Source: Molecular Cancer - May 11, 2020 Category: Cancer & Oncology Authors: Xi Jin, Li-Ping Ge, Da-Qiang Li, Zhi-Ming Shao, Gen-Hong Di, Xiao-En Xu and Yi-Zhou Jiang Tags: Research Source Type: research

Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression
As a novel type of noncoding RNAs, covalently closed circular RNAs (circRNAs) are ubiquitously expressed in eukaryotes. Emerging studies have related dysregulation of circRNAs to tumorigenesis. However, the bi... (Source: Molecular Cancer)
Source: Molecular Cancer - May 9, 2020 Category: Cancer & Oncology Authors: Zai Luo, Zeyin Rong, Jianming Zhang, Zhonglin Zhu, Zhilong Yu, Tengfei Li, Zhongmao Fu, Zhengjun Qiu and Chen Huang Tags: Research Source Type: research

LncRNA BCRT1 promotes breast cancer progression by targeting miR-1303/PTBP3 axis
Long noncoding RNAs (lncRNAs) play crucial roles in tumor progression and are aberrantly expressed in various cancers. However, the functional roles of lncRNAs in breast cancer remain largely unknown. (Source: Molecular Cancer)
Source: Molecular Cancer - May 8, 2020 Category: Cancer & Oncology Authors: Yiran Liang, Xiaojin Song, Yaming Li, Bing Chen, Wenjing Zhao, Lijuan Wang, Hanwen Zhang, Ying Liu, Dianwen Han, Ning Zhang, Tingting Ma, Yajie Wang, Fangzhou Ye, Dan Luo, Xiaoyan Li and Qifeng Yang Tags: Research Source Type: research

Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma
Circular RNAs (circRNAs) have been reported to have critical regulatory roles in tumor biology. However, their contribution to melanoma remains largely unknown. (Source: Molecular Cancer)
Source: Molecular Cancer - May 7, 2020 Category: Cancer & Oncology Authors: Chuan-Yuan Wei, Meng-Xuan Zhu, Nan-Hang Lu, Jia-Qi Liu, Yan-Wen Yang, Yong Zhang, Yue-Dong Shi, Zi-Hao Feng, Jia-Xia Li, Fa-Zhi Qi and Jian-Ying Gu Tags: Research Source Type: research

Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis
Accumulating evidence suggests that circular RNAs (circRNAs) are important participants in cancer progression. However, the biological processes and underlying mechanisms of circRNAs in pancreatic ductal adeno... (Source: Molecular Cancer)
Source: Molecular Cancer - May 6, 2020 Category: Cancer & Oncology Authors: Xiaofeng Guo, Quanbo Zhou, Dan Su, Yuming Luo, Zhiqiang Fu, Leyi Huang, Zhiguo Li, Decan Jiang, Yao Kong, Zhihua Li, Rufu Chen and Changhao Chen Tags: Research Source Type: research

circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer
Patients with lymph node (LN)-positive pancreatic ductal adenocarcinoma (PDAC) have extremely poor survival rates. Circular RNAs (circRNAs), a newly discovered type of endogenous noncoding RNAs, have been prop... (Source: Molecular Cancer)
Source: Molecular Cancer - May 4, 2020 Category: Cancer & Oncology Authors: Yao Kong, Yuting Li, Yuming Luo, Jiang Zhu, Hanhao Zheng, Bowen Gao, Xiaofeng Guo, Zhihua Li, Rufu Chen and Changhao Chen Tags: Research Source Type: research

The biomarkers of hyperprogressive disease in PD-1/PD-L1 blockage therapy
Immune checkpoint inhibitors (ICIs), such as PD-1/PD-L1 antibodies (Abs) and anti-cytotoxic T lymphocyte antigen 4 (CTLA-4) Abs, are effective for patients with various cancers. However, low response rates to ... (Source: Molecular Cancer)
Source: Molecular Cancer - May 2, 2020 Category: Cancer & Oncology Authors: Xueping Wang, Fang Wang, Mengjun Zhong, Yosef Yarden and Liwu Fu Tags: Review Source Type: research

Analysis of the susceptibility of lung cancer patients to SARS-CoV-2 infection
In this study, we investigated the gene expression of angiotensin I-conver... (Source: Molecular Cancer)
Source: Molecular Cancer - April 28, 2020 Category: Cancer & Oncology Authors: Qi Kong, Zhiguang Xiang, Yue Wu, Yu Gu, Jianguo Guo and Fei Geng Tags: Letter to the Editor Source Type: research

Epigenetic regulation in human cancer: the potential role of epi-drug in cancer therapy
Epigenetics is dynamic and heritable modifications to the genome that occur independently of DNA sequence. It requires interactions cohesively with various enzymes and other molecular components. Aberrant epig... (Source: Molecular Cancer)
Source: Molecular Cancer - April 27, 2020 Category: Cancer & Oncology Authors: Yuanjun Lu, Yau-Tuen Chan, Hor-Yue Tan, Sha Li, Ning Wang and Yibin Feng Tags: Review Source Type: research

Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
RNA modifications can be added or removed by a variety of enzymes that catalyse the necessary reactions, and these modifications play roles in essential molecular mechanisms. The prevalent modifications on mRN... (Source: Molecular Cancer)
Source: Molecular Cancer - April 17, 2020 Category: Cancer & Oncology Authors: Hanhan Shi, Peiwei Chai, Renbing Jia and Xianqun Fan Tags: Review Source Type: research

The role of long noncoding RNAs in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is the most frequent subtype of primary liver cancer and one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms underlying HCC pathogenesi... (Source: Molecular Cancer)
Source: Molecular Cancer - April 15, 2020 Category: Cancer & Oncology Authors: Zhao Huang, Jian-Kang Zhou, Yong Peng, Weifeng He and Canhua Huang Tags: Review Source Type: research

RNA-seq reveals novel CircRNAs involved in breast cancer progression and patient therapy response
(Source: Molecular Cancer)
Source: Molecular Cancer - April 15, 2020 Category: Cancer & Oncology Authors: Christophe Nicot Tags: Editorial Source Type: research

Correction to: CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling
Following the publication of the original paper [1], one corresponding author was inadvertently missed. (Source: Molecular Cancer)
Source: Molecular Cancer - April 14, 2020 Category: Cancer & Oncology Authors: Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen and Xiangqian Fang Tags: Correction Source Type: research

Oncogenic seRNA functional activation: a novel mechanism of tumorigenesis
seRNA is a noncoding RNA (ncRNA) transcribed from active super-enhancer (SE), through which SE exerts biological functions and participates in various physiological and pathological processes. seRNA recruits c... (Source: Molecular Cancer)
Source: Molecular Cancer - April 11, 2020 Category: Cancer & Oncology Authors: Yuan Tan, Yuejin Li and Faqing Tang Tags: Review Source Type: research

The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer
Increasing studies have shown that circRNA is closely related to the carcinogenesis and development of many cancers. However, biological functions and the underlying molecular mechanism of circRNAs in triple-n... (Source: Molecular Cancer)
Source: Molecular Cancer - April 7, 2020 Category: Cancer & Oncology Authors: Xiaying Zheng, Mengge Huang, Lei Xing, Rui Yang, Xiaosong Wang, Rong Jiang, Luyu Zhang and Junxia Chen Tags: Research Source Type: research

m6A-dependent glycolysis enhances colorectal cancer progression
Epigenetic alterations are involved in various aspects of colorectal carcinogenesis. N6-methyladenosine (m6A) modifications of RNAs are emerging as a new layer of epigenetic regulation. As the most abundant chemi... (Source: Molecular Cancer)
Source: Molecular Cancer - April 3, 2020 Category: Cancer & Oncology Authors: Chaoqin Shen, Baoqin Xuan, Tingting Yan, Yanru Ma, Pingping Xu, Xianglong Tian, Xinyu Zhang, Yingying Cao, Dan Ma, Xiaoqiang Zhu, Youwei Zhang, Jing-Yuan Fang, Haoyan Chen and Jie Hong Tags: Research Source Type: research

Disruption of the RNA modifications that target the ribosome translation machinery in human cancer
Genetic and epigenetic changes deregulate RNA and protein expression in cancer cells. In this regard, tumors exhibit an abnormal proteome in comparison to the corresponding normal tissues. Translation control ... (Source: Molecular Cancer)
Source: Molecular Cancer - April 2, 2020 Category: Cancer & Oncology Authors: Maxime Janin, Laia Coll-SanMartin and Manel Esteller Tags: Review Source Type: research

A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer
Colon cancer (CC) is a common malignant cancer. Recently, circFNDC3B was found to exert biological function in multiple cancers. However, it was unclear whether the potential protein encoded by circFNDC3B is i... (Source: Molecular Cancer)
Source: Molecular Cancer - April 2, 2020 Category: Cancer & Oncology Authors: Zihao Pan, Jianye Cai, Jiatong Lin, Huinian Zhou, Jingwen Peng, Jinliang Liang, Long Xia, Qi Yin, Baojia Zou, Jun Zheng, Liang Qiao and Lei Zhang Tags: Research Source Type: research

Dying tumor cell-derived exosomal miR-194-5p potentiates survival and repopulation of tumor repopulating cells upon radiotherapy in pancreatic cancer
Tumor repopulation is a major cause of radiotherapy failure. Previous investigations highlighted that dying tumor cells played vital roles in tumor repopulation through promoting proliferation of the residual ... (Source: Molecular Cancer)
Source: Molecular Cancer - March 30, 2020 Category: Cancer & Oncology Authors: Ming-jie Jiang, Yi-yun Chen, Juan-juan Dai, Dian-na Gu, Zhu Mei, Fu-rao Liu, Qian Huang and Ling Tian Tags: Research Source Type: research

Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin
Non coding RNAs (ncRNAs) have emerged as regulators of human carcinogenesis by affecting the expression of key tumor suppressor genes and oncogenes. They are divided into short and long ncRNAs, according to th... (Source: Molecular Cancer)
Source: Molecular Cancer - March 30, 2020 Category: Cancer & Oncology Authors: Martina Ghetti, Ivan Vannini, Clelia Tiziana Storlazzi, Giovanni Martinelli and Giorgia Simonetti Tags: Review Source Type: research

Correction to: Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/Vimentin axis
After publication of the article [1], the authors reported errors of inter-duplication in Figure 3. (Source: Molecular Cancer)
Source: Molecular Cancer - March 27, 2020 Category: Cancer & Oncology Authors: Zhonglin Zhu, Zeyin Rong, Zai Luo, Zhilong Yu, Jing Zhang, Zhengjun Qiu and Chen Huang Tags: Correction Source Type: research

Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression
In this study, we aim to exp... (Source: Molecular Cancer)
Source: Molecular Cancer - March 25, 2020 Category: Cancer & Oncology Authors: Gehao Liang, Yun Ling, Maryam Mehrpour, Phei Er Saw, Zihao Liu, Weige Tan, Zhenluan Tian, Wenjing Zhong, Wanyi Lin, Qing Luo, Qun Lin, Qiufang Li, You Zhou, Ahmed Hamai, Patrice Codogno, Jun Li & hellip; Tags: Research Source Type: research

Exosomal noncoding RNAs in Glioma: biological functions and potential clinical applications
Gliomas are complex and heterogeneous brain tumors with poor prognosis. Glioma cells can communicate with their surroundings to create a tumor-permissive microenvironment. Exosomes represent a new means of int... (Source: Molecular Cancer)
Source: Molecular Cancer - March 25, 2020 Category: Cancer & Oncology Authors: Jian Cheng, Jinli Meng, Lei Zhu and Yong Peng Tags: Review Source Type: research