Systematic optimization and evaluation of culture conditions for the construction of circulating tumor cell clusters using breast cancer cell lines
Circulating tumor cell (CTC) clusters play a critical role in carcinoma metastasis. However, the rarity of CTC clusters and the limitations of capture techniques have retarded the research progress. In vitro C... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Jueyao Zou, Qiong Chen, Yong He, Yanhong Pan, Han Zhao, Junfeng Shi, Zhonghong Wei, Suyun Yu, Yang Zhao, Xin Han, Yin Lu and Wenxing Chen Tags: Research Source Type: research
Expression of STAT3 and hypoxia markers in long-term surviving malignant glioma patients
Glioblastoma is a malignant and aggressive type of central nevous system malignancy characterized by many distinct biological features including extensive hypoxia. Hypoxia in glioblatoma associates with comple... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Katerina Dvorakova, Veronika Skarkova, Barbora Vitovcova, Jiri Soukup, Hana Vosmikova, Zuzana Pleskacova, Adam Skarka, Michael Christian Bartos, Petr Krupa, Petra Kasparova, Jiri Petera and Emil Rudolf Tags: Research Source Type: research
Deep learning-assisted diagnosis of benign and malignant parotid tumors based on ultrasound: a retrospective study
To develop a deep learning(DL) model utilizing ultrasound images, and evaluate its efficacy in distinguishing between benign and malignant parotid tumors (PTs), as well as its practicality in assisting clinici... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Tian Jiang, Chen Chen, Yahan Zhou, Shenzhou Cai, Yuqi Yan, Lin Sui, Min Lai, Mei Song, Xi Zhu, Qianmeng Pan, Hui Wang, Xiayi Chen, Kai Wang, Jing Xiong, Liyu Chen and Dong Xu Tags: Research Source Type: research
CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis
Although papillary thyroid carcinoma (PTC) has a favorable prognosis, it could affect patient life quality and become a serious threat because of invasion and metastasis. Many investigations have suggested tha... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2024 Category: Cancer & Oncology Authors: Jiying Shen, Zhirong Ma, Jin Yang, Tianzhen Qu, Yu Xia, Yingjie Xu, Ming Zhou and Weiwei Liu Tags: Research Source Type: research
PROTAC EZH2 degrader-1 overcomes the resistance of podophyllotoxin derivatives in refractory small cell lung cancer with leptomeningeal metastasis
Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting ch... (Source: BMC Cancer)
Source: BMC Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Min-xing Shi, Xi Ding, Liang Tang, Wei-jun Cao, Bo Su and Jie Zhang Tags: Research Source Type: research
25-hydroxycholesterol promotes proliferation and metastasis of lung adenocarcinoma cells by regulating ER β/TNFRSF17 axis
Lung adenocarcinoma is the main type of lung cancer in women. Our previous findings have evidenced that 25-hydroxycholesterol (25-HC) promotes migration and invasion of lung adenocarcinoma cells (LAC), during ... (Source: BMC Cancer)
Source: BMC Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Mengting He, Wenbo Jiang, Xingkai Li, Hongjin Liu, Hongsheng Ren and Yanliang Lin Tags: Research Source Type: research
m1A regulator-mediated methylation modification patterns correlated with autophagy to predict the prognosis of hepatocellular carcinoma
N1-methyladenosine (m1A), among the most common internal modifications on RNAs, has a crucial role to play in cancer development. The purpose of this study were systematically investigate the modification charact... (Source: BMC Cancer)
Source: BMC Cancer - April 22, 2024 Category: Cancer & Oncology Authors: Yingmin Wu, Lian Li, Long Wang, Shenjie Zhang, Zhirui zeng, Jieyu Lu, Zhi Wang, Yewei Zhang, Shilong Zhang, Haiyang Li and Tengxiang Chen Tags: Research Source Type: research
Integrated clinical and genomic models using machine-learning methods to predict the efficacy of paclitaxel-based chemotherapy in patients with advanced gastric cancer
Paclitaxel is commonly used as a second-line therapy for advanced gastric cancer (AGC). The decision to proceed with second-line chemotherapy and select an appropriate regimen is critical for vulnerable patien... (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Yonghwa Choi, Jangwoo Lee, Keewon Shin, Ji Won Lee, Ju Won Kim, Soohyeon Lee, Yoon Ji Choi, Kyong Hwa Park and Jwa Hoon Kim Tags: Research Source Type: research
Comparative characteristics of early-onset vs. late-onset advanced colorectal cancer: a nationwide study in China
The incidence of early-onset colorectal cancer (EOCRC, diagnosed in patients under the age of 50 years) has been increasing around the world. Here, we aimed to systematically identify distinctive features of E... (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2024 Category: Cancer & Oncology Authors: Hongwei Liu, Huifang Xu, Yin Liu, Yuqian Zhao, Xi Zhang, Yanqin Yu, Lingbin Du, Yunyong Liu, Wenjun Wang, Helu Cao, Li Ma, Juanxiu Huang, Ji Cao, Li Li, Yanping Fan, Xiaofen Gu & hellip; Tags: Research Source Type: research
Development and validation of a patient reported experience measure for experimental cancer medicines (PREM-ECM) and their carers (PREM-ECM-Carer)
Our aim was to develop a validated Patient Reported Experience Measure (PREM) to capture patient and carer experience during participation in experimental cancer medicine trials (ECM): called PREM-ECM. (Source: BMC Cancer)
Source: BMC Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Chelsea S. Sawyer, Sally Taylor, Louise Carter, Melissa Stanworth, Michelle Davies, Fiona Thistlethwaite, Jo Taylor, Charlotte Eastwood and Janelle Yorke Tags: Research Source Type: research
The efficacy and safety of short-course radiotherapy followed by sequential chemotherapy and Cadonilimab for locally advanced rectal cancer: a protocol of a phase II study
For patients with locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT), namely, intensifying preoperative treatment through the integration of radiotherapy and systemic chemotherapy before su... (Source: BMC Cancer)
Source: BMC Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Tongzhen Xu, Lingling Feng, Wenjue Zhang, Haoyue Li, Huiying Ma, Muyasha Abulimiti, Yutong Tan, Feiyan Deng, Wenting Huang, Shuangmei Zou, Wenyan Kang, Liming Jiang, Ying Wang, Chen Hu, Yinggang Chen, Haitao Zhou & hellip; Tags: Study Protocol Source Type: research
Central venous access device terminologies, complications, and reason for removal in oncology: a scoping review
Lack of agreed terminology and definitions in healthcare compromises communication, patient safety, optimal management of adverse events, and research progress. The purpose of this scoping review was to unders... (Source: BMC Cancer)
Source: BMC Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Kerrie Curtis, Karla Gough, Meinir Krishnasamy, Elena Tarasenko, Geoff Hill and Samantha Keogh Tags: Research Source Type: research
Germline mutations in BRCA1 and BRCA2 among Brazilian women with ovarian cancer treated in the Public Health System
Germline mutations in BRCA1 and BRCA2 genes are among the main causes of hereditary ovarian cancer. Identifying these mutations may reduce cancer risk, facilitate early detection, and enable personalized treat... (Source: BMC Cancer)
Source: BMC Cancer - April 19, 2024 Category: Cancer & Oncology Authors: Caroline de Oliveira Ferreira, Vandr é Cabral Gomes Carneiro and Carolline Araujo Mariz Tags: Research Source Type: research
Ferroptosis-related lncRNA NRAV affects the prognosis of hepatocellular carcinoma via the miR-375-3P/SLC7A11 axis
Ferroptosis has important value in cancer treatment. It is significant to explore the new ferroptosis-related lncRNAs prediction model in Hepatocellular carcinoma (HCC) and the potential molecular mechanism of... (Source: BMC Cancer)
Source: BMC Cancer - April 18, 2024 Category: Cancer & Oncology Authors: Ke Zong, Caifeng Lin, Kai Luo, Yilei Deng, Hongfei Wang, Jianfei Hu, Shi Chen and Renfeng Li Tags: Research Source Type: research
Development and validation of a nomogram for predicting sever cancer-related fatigue in patients with cervical cancer
This study aimed to develop and validate a nomogram for severe cancer-related fatigue (CRF) pa... (Source: BMC Cancer)
Source: BMC Cancer - April 18, 2024 Category: Cancer & Oncology Authors: ZhiHui Gu, ChenXin Yang, Ke Zhang and Hui Wu Tags: Research Source Type: research
