Hypoxia promotes acquisition of aggressive phenotypes in human malignant mesothelioma
Hypoxia is a hallmark of the solid tumor microenvironment and is associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying the hypoxia-induced pheno... (Source: BMC Cancer)
Source: BMC Cancer - August 15, 2018 Category: Cancer & Oncology Authors: Myung-Chul Kim, Sung-Hyun Hwang, Na-Yon Kim, Hong-Seok Lee, Sumin Ji, Yeseul Yang and Yongbaek Kim Tags: Research article Source Type: research

Targeting colorectal cancer cell metabolism through development of cisplatin and metformin nano-cubosomes
Colorectal cancer (CRC) remains a leading cause of death worldwide. Utilizing cisplatin in CRC is correlated with severe adverse effects and drug-resistance. Combined anticancer drug-treatment, along with, the... (Source: BMC Cancer)
Source: BMC Cancer - August 15, 2018 Category: Cancer & Oncology Authors: Mona M. Saber, Abdulaziz M. Al-mahallawi, Noha N. Nassar, Bj örn Stork and Samia A. Shouman Tags: Research article Source Type: research

Chemotherapy-induced peripheral neuropathy: evidence from genome-wide association studies and replication within multiple myeloma patients
Based on the possible shared mechanisms of chemotherapy-induced peripheral neuropathy (CIPN) for different drugs, we aimed to aggregate results of all previously published genome-wide association studies (GWAS... (Source: BMC Cancer)
Source: BMC Cancer - August 15, 2018 Category: Cancer & Oncology Authors: Seyed Hamidreza Mahmoudpour, Obul Reddy Bandapalli, Miguel In ácio da Silva Filho, Chiara Campo, Kari Hemminki, Hartmut Goldschmidt, Maximilian Merz and Asta Försti Tags: Research article Source Type: research

Colorectal liver metastases: surgery versus thermal ablation (COLLISION) – a phase III single-blind prospective randomized controlled trial
Radiofrequency ablation (RFA) and microwave ablation (MWA) are widely accepted techniques to eliminate small unresectable colorectal liver metastases (CRLM). Although previous studies labelled thermal ablation... (Source: BMC Cancer)
Source: BMC Cancer - August 15, 2018 Category: Cancer & Oncology Authors: Robbert S. Puijk, Alette H. Ruarus, Laurien G. P. H. Vroomen, Aukje A. J. M. van Tilborg, Hester J. Scheffer, Karin Nielsen, Marcus C. de Jong, Jan J. J. de Vries, Babs M. Zonderhuis, Hasan H. Eker, Geert Kazemier, Henk Verheul, Bram B. van der Meijs, Lau Tags: Study protocol Source Type: research

Examining transcriptional changes to DNA replication and repair factors over uveal melanoma subtypes
Uncontrolled replication is a process common to all cancers facilitated by the summation of changes accumulated as tumors progress. The aim of this study was to examine small groups of genes with known biology... (Source: BMC Cancer)
Source: BMC Cancer - August 14, 2018 Category: Cancer & Oncology Authors: Melanie Kucherlapati Tags: Research article Source Type: research

A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells
Breast cancer is the most common malignancy in women worldwide. Although the endocrine therapy that targets estrogen receptor α (ERα) signaling has been well established as an effective adjuvant treatment for ... (Source: BMC Cancer)
Source: BMC Cancer - August 13, 2018 Category: Cancer & Oncology Authors: Bo Wang, Dongping Li, Rocio Rodriguez-Juarez, Allison Farfus, Quinn Storozynsky, Megan Malach, Emily Carpenter, Jody Filkowski, Anne E. Lykkesfeldt and Olga Kovalchuk Tags: Research article Source Type: research

CREB3L1 as a potential biomarker predicting response of triple negative breast cancer to doxorubicin-based chemotherapy
Doxorubicin-based chemotherapy is currently the most frequently used treatment for triple negative breast cancer (TNBC), yet the response rate is not high due to the lack of a biomarker allowing identification... (Source: BMC Cancer)
Source: BMC Cancer - August 13, 2018 Category: Cancer & Oncology Authors: Bray Denard, Sharon Jiang, Yan Peng and Jin Ye Tags: Research article Source Type: research

MRI in predicting the response of gastrointestinal stromal tumor to targeted therapy: a patient-based multi-parameter study
To investigate the performance of quantitative indicators of MRI in early prediction of the response of gastrointestinal stromal tumor (GIST) to targeted therapy in a patient-based study. (Source: BMC Cancer)
Source: BMC Cancer - August 13, 2018 Category: Cancer & Oncology Authors: Lei Tang, Jian Li, Zi-Yu Li, Xiao-Ting Li, Ji-Fang Gong, Jia-Fu Ji, Ying-Shi Sun and Lin Shen Tags: Research article Source Type: research

Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma
To estimate the prognostic value of inflammatory markers in patients with laryngeal squamous cell carcinoma (LSCC). (Source: BMC Cancer)
Source: BMC Cancer - August 13, 2018 Category: Cancer & Oncology Authors: Linyan Chen, Hao Zeng, Jiapeng Yang, Yuqing Lu, Dan Zhang, Jinggan Wang, Chienyun Kuang, Sha Zhu, Manni Wang and Xuelei Ma Tags: Research article Source Type: research

Rational development of synergistic combinations of chemotherapy and molecular targeted agents for colorectal cancer treatment
The irinotecan-induced phosphokinome changes in colorectal cancer (CRC) cells were used to guide the selection of targeted agents to be tested in combination with irinotecan. (Source: BMC Cancer)
Source: BMC Cancer - August 13, 2018 Category: Cancer & Oncology Authors: Diego Tosi, Esther P érez-Gracia, Salima Atis, Nadia Vié, Eve Combès, Mélissa Gabanou, Christel Larbouret, Marta Jarlier, Caroline Mollevi, Adeline Torro, Maguy Del Rio, Pierre Martineau and Céline Gongora Tags: Research article Source Type: research

Early increase in blood supply (EIBS) is associated with tumor risk in the Azoxymethane model of colon cancer
The present study aimed to investigate the role of blood supply in early tumorigenesis in colorectal cancer. We leveraged the renin angiotensin system (RAS) to alter colonic blood supply and determine the effe... (Source: BMC Cancer)
Source: BMC Cancer - August 13, 2018 Category: Cancer & Oncology Authors: Sarah Ruderman, Adam Eshein, Vesta Valuckaite, Urszula Dougherty, Anas Almoghrabi, Andrew Gomes, Ajaypal Singh, Baldeep Pabla, Hemant K. Roy, John Hart, Marc Bissonnette, Vani Konda and Vadim Backman Tags: Research article Source Type: research

Comparison of cervical cancer screening among women with and without hysterectomies: a nationwide population-based study in Korea
Cervical cancer screening is not recommended for women who underwent hysterectomy with no history of cervical intraepithelial neoplasia (CIN) of grade 2 or higher. We aimed to determine the cervical cancer scr... (Source: BMC Cancer)
Source: BMC Cancer - August 11, 2018 Category: Cancer & Oncology Authors: Ji-Yeon Shin, Kui Son Choi, Mina Suh, Boyoung Park and Jae Kwan Jun Tags: Research article Source Type: research

Irinotecan-platinum combination therapy for previously untreated extensive-stage small cell lung cancer patients: a meta-analysis
There is still a debate regarding whether regimens combining irinotecan with platinum could replace regimens combining etoposide with platinum, as first-line chemotherapy for extensive-stage small cell lung ca... (Source: BMC Cancer)
Source: BMC Cancer - August 10, 2018 Category: Cancer & Oncology Authors: Fei Xu, Xiaoli Ren, Yuan Chen, Qianxia Li, Ruichao Li, Yu Chen and Shu Xia Tags: Research article Source Type: research

Natural product derivative Gossypolone inhibits Musashi family of RNA-binding proteins
The Musashi (MSI) family of RNA-binding proteins is best known for the role in post-transcriptional regulation of target mRNAs. Elevated MSI1 levels in a variety of human cancer are associated with up-regulati... (Source: BMC Cancer)
Source: BMC Cancer - August 10, 2018 Category: Cancer & Oncology Authors: Lan Lan, Hao Liu, Amber R. Smith, Carl Appelman, Jia Yu, Sarah Larsen, Rebecca T. Marquez, Xiaoqing Wu, Frank Y. Liu, Philip Gao, Ragul Gowthaman, John Karanicolas, Roberto N. De Guzman, Steven Rogers, Jeffrey Aub é, Kristi L. Neufeld & hellip; Tags: Research article Source Type: research

An elderly patient presenting with a primary spinal multifocal intradural extramedullary pilocytic astrocytoma: a case report and review of the literature
Pilocytic astrocytoma is a low-grade central nervous system tumor most commonly seen in children. Dissemination from a primary intracranial tumor along the neuroaxis has been described at both presentation and... (Source: BMC Cancer)
Source: BMC Cancer - August 9, 2018 Category: Cancer & Oncology Authors: Devin McBride, Zaid Aljuboori, Eyas M. Hattab, Richard Downs, Shiao Woo, Brian Williams, Joseph Neimat and Eric Burton Tags: Case report Source Type: research

International pilot external quality assessment scheme for analysis and reporting of circulating tumour DNA
Molecular analysis of circulating tumour DNA (ctDNA) is becoming increasingly important in clinical treatment decisions. A pilot External Quality Assessment (EQA) scheme for ctDNA analysis was organized by fou... (Source: BMC Cancer)
Source: BMC Cancer - August 9, 2018 Category: Cancer & Oncology Authors: Cleo Keppens, Elisabeth M. C. Dequeker, Simon J. Patton, Nicola Normanno, Francesca Fenizia, Rachel Butler, Melanie Cheetham, Jennifer A. Fairley, Hannah Williams, Jacqueline A. Hall, Ed Schuuring and Zandra C. Deans Tags: Research article Source Type: research

Fatty acid oxidation is associated with proliferation and prognosis in breast and other cancers
Altered cellular metabolism is a hallmark of cancer but the association between utilisation of particular metabolic pathways in tumours and patient outcome is poorly understood. We sought to investigate the as... (Source: BMC Cancer)
Source: BMC Cancer - August 9, 2018 Category: Cancer & Oncology Authors: Aziz Aiderus, Michael A. Black and Anita K. Dunbier Tags: Research article Source Type: research

Comparison of local tumor control in patients with HCC treated with SBRT or TACE: a propensity score analysis
As stereotactic body radiation therapy (SBRT) has shown to be effective and safe in patients with hepatocellular carcinoma (HCC), the aim of our propensity score matched analysis was to evaluate the efficacy o... (Source: BMC Cancer)
Source: BMC Cancer - August 9, 2018 Category: Cancer & Oncology Authors: Dominik Bettinger, Eleni Gkika, Michael Schultheiss, Nicolas Glaser, Sophie Lange, Lars Maruschke, Nico Buettner, Simon Kirste, Ursula Nestle, Anca-Ligia Grosu, Robert Thimme and Thomas B. Brunner Tags: Research article Source Type: research

Second primary cancer after primary peritoneal, epithelial ovarian, and fallopian tubal cancer: a retrospective study
In this retrospective study, data from patients listed in the Korea Central Cancer Registry during 1993 –2014 were analysed, to investigate the incidence and survival of second primary cancers (SPCs) after a di... (Source: BMC Cancer)
Source: BMC Cancer - August 8, 2018 Category: Cancer & Oncology Authors: Myong Cheol Lim, Young-Joo Won, Jiwon Lim, Tahereh Salehi, Chong Woo Yoo and Robert E. Bristow Tags: Research article Source Type: research

Diffuse parenchymal pulmonary amyloidosis associated with multiple myeloma: a case report and systematic review of the literature
We report a rare case of diffuse parenchyma... (Source: BMC Cancer)
Source: BMC Cancer - August 8, 2018 Category: Cancer & Oncology Authors: Yin Liu, Zhibin Jin, Haiyan Zhang, Yingwei Zhang, Minke Shi, Fanqing Meng, Qi Sun and Hourong Cai Tags: Case report Source Type: research

Improved outcome in patients following autologous stem cell transplantation for multiple myeloma in south eastern Norway 2001 –2010: a retrospective, population based analysis
With the advent of novel drugs improved overall survival in patients with multiple myeloma, including patients who received up-front autologous stem cell transplantation (ASCT), has been reported from several ... (Source: BMC Cancer)
Source: BMC Cancer - August 8, 2018 Category: Cancer & Oncology Authors: Jon-Magnus Tangen, Geir Erland Tj ønnfjord, Nina Gulbrandsen, Tobias Gedde-Dahl, Espen Stormorken, Kristina Anderson, Camilla Dao Vo and Fredrik Hellem Schjesvold Tags: Research article Source Type: research

A prospective phase I study of hypo-fractionated neoadjuvant radiotherapy for locally advanced gastric cancer
Previous studies have reported that neoadjuvant chemoradiotherapy can downstage the advanced gastric cancer. However, no studies are available on the application of hypo-radiotherapy to neoadjuvant radiotherap... (Source: BMC Cancer)
Source: BMC Cancer - August 8, 2018 Category: Cancer & Oncology Authors: Ning Li, Xin Wang, Yuan Tang, Dongbing Zhao, Yihebali Chi, Lin Yang, Liming Jiang, Jun Jiang, Wenyang Liu, Yu Tang, Hui Fang, Yueping Liu, Yongwen Song, Shulian Wang, Jing Jin and Yexiong Li Tags: Research article Source Type: research

LC-MS based sphingolipidomic study on A549 human lung adenocarcinoma cell line and its taxol-resistant strain
Resistance to chemotherapy drugs (e.g. taxol) has been a major obstacle in successful cancer treatment. In A549 human lung adenocarcinoma, acquired resistance to the first-line chemotherapy taxol has been a cr... (Source: BMC Cancer)
Source: BMC Cancer - August 8, 2018 Category: Cancer & Oncology Authors: Hao Huang, Tian-Tian Tong, Lee-Fong Yau, Cheng-Yu Chen, Jia-Ning Mi, Jing-Rong Wang and Zhi-Hong Jiang Tags: Research article Source Type: research

Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice
Hormone sensitive lipase (HSL) is a neutral lipase that preferentially catalyzes the hydrolysis of diacylglycerol contributing to triacylglycerol breakdown in the adipose tissue. HSL has been implicated to pla... (Source: BMC Cancer)
Source: BMC Cancer - August 7, 2018 Category: Cancer & Oncology Authors: Mu Xu, Hui-Hua Chang, Xiaoman Jung, Aune Moro, Caroline Ei Ne Chou, Jonathan King, O. Joe Hines, James Sinnett-Smith, Enrique Rozengurt and Guido Eibl Tags: Research article Source Type: research

Liver cancer mortality trends in South Africa: 1999 –2015
In South Africa (SA), liver cancer (LC) is a public health problem and information is limited. (Source: BMC Cancer)
Source: BMC Cancer - August 7, 2018 Category: Cancer & Oncology Authors: Daniel Mak, Mazvita Sengayi, Wenlong C. Chen, Chantal Babb de Villiers, Elvira Singh and Anna Kramvis Tags: Research article Source Type: research

RandomiSed clinical trial assessing Use of an anti-inflammatoRy aGent in attenUating peri-operatiVe inflAmmatioN in non-meTastatic colon cancer – the S.U.R.G.U.V.A.N.T. trial
Peri-operative inflammation has been extensively highlighted in cancer patients as detrimental. Treatment strategies to improve survival for cancer patients through targeting peri-operative inflammation have y... (Source: BMC Cancer)
Source: BMC Cancer - August 6, 2018 Category: Cancer & Oncology Authors: H. Paul Redmond, Peter M. Neary, Marcel Jinih, Emer O ’Connell, Niamh Foley, Rolf W. Pfirrmann, Jiang H. Wang and D. Peter O’Leary Tags: Research article Source Type: research

Favorable mortality-to-incidence ratios of kidney Cancer are associated with advanced health care systems
The advancements in cancer therapy have improved the clinical outcomes of cancer patients in recent decades. However, advanced cancer therapy is expensive and requires good health care systems. For kidney canc... (Source: BMC Cancer)
Source: BMC Cancer - August 6, 2018 Category: Cancer & Oncology Authors: Wen-Wei Sung, Shao-Chuan Wang, Tzuo-Yi Hsieh, Cheng-Ju Ho, Cheng-Yu Huang, Yu-Lin Kao, Wen-Jung Chen and Sung-Lang Chen Tags: Research article Source Type: research

Safety and tolerability of quizartinib, a FLT3 inhibitor, in advanced solid tumors: a phase 1 dose-escalation trial
Quizartinib, an inhibitor of class III receptor tyrosine kinases (RTKs), is currently in phase 3 development for the treatment of acute myeloid leukemia (AML) bearing internal tandem duplications in the FLT3 gene... (Source: BMC Cancer)
Source: BMC Cancer - August 6, 2018 Category: Cancer & Oncology Authors: Kyriakos P. Papadopoulos, Eytan Ben-Ami, Amita Patnaik, Denise Trone, Jianke Li and George D. Demetri Tags: Research article Source Type: research

A multicenter study investigating the molecular fingerprint of psychological resilience in breast cancer patients: study protocol of the SCAN-B resilience study
Individual patients differ in their psychological response when receiving a cancer diagnosis, in this case breast cancer. Given the same disease burden, some patients master the situation well, while others ex... (Source: BMC Cancer)
Source: BMC Cancer - August 6, 2018 Category: Cancer & Oncology Authors: Ulrika Axelsson, Lisa Ryd én, Per Johnsson, Patrik Edén, Johanna Månsson, Ingalill Rahm Hallberg and Carl A. K. Borrebaeck Tags: Study protocol Source Type: research

Novel small molecule SIRT2 inhibitors induce cell death in leukemic cell lines
Sirtuin 2 (SIRT2) is a member of the sirtuin family, nicotinamide adenine dinucleotide+-dependent deacylases, which participates in modulation of cell cycle control, neurodegeneration, and tumorigenesis. SIRT2 ex... (Source: BMC Cancer)
Source: BMC Cancer - August 6, 2018 Category: Cancer & Oncology Authors: Tomohiro Kozako, Paolo Mellini, Takeo Ohsugi, Akiyoshi Aikawa, Yu-ichiro Uchida, Shin-ichiro Honda and Takayoshi Suzuki Tags: Research article Source Type: research

Achieving optimal response at 12 months is associated with a better health-related quality of life in patients with chronic myeloid leukemia: a prospective, longitudinal, single center study
To assess the relationship between responses within 1 year and health-related quality of life (HRQoL) outcomes by exploring profiles of patients with CML-CP who were treated with front-line imatinib or nilotinib. (Source: BMC Cancer)
Source: BMC Cancer - August 3, 2018 Category: Cancer & Oncology Authors: Lu Yu, Haibo Wang, Darko Milijkovic, Xiaojun Huang and Qian Jiang Tags: Research article Source Type: research

Barrett ’s oESophagus trial 3 (BEST3): study protocol for a randomised controlled trial comparing the Cytosponge-TFF3 test with usual care to facilitate the diagnosis of oesophageal pre-cancer in primary care patients with chronic acid reflux
Early detection of oesophageal cancer improves outcomes; however, the optimal strategy for identifying patients at increased risk from the pre-cancerous lesion Barrett ’s oesophagus (BE) is not clear. The Cytos... (Source: BMC Cancer)
Source: BMC Cancer - August 3, 2018 Category: Cancer & Oncology Authors: Judith Offman, Beth Muldrew, Maria O ’Donovan, Irene Debiram-Beecham, Francesca Pesola, Irene Kaimi, Samuel G. Smith, Ashley Wilson, Zohrah Khan, Pierre Lao-Sirieix, Benoit Aigret, Fiona M. Walter, Greg Rubin, Steve Morris, Christopher Jackson, Peter Sa Tags: Study protocol Source Type: research

Enrichment of cancer stem cells via β-catenin contributing to the tumorigenesis of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is among the deadliest cancers due to its heterogeneity, contributing to chemoresistance and recurrence. Cancer stem-like cells (CSCs) are suggested to play an important role in ... (Source: BMC Cancer)
Source: BMC Cancer - August 3, 2018 Category: Cancer & Oncology Authors: Harshul Pandit, Yan Li, Xuanyi Li, Weizhong Zhang, Suping Li and Robert C. G. Martin Tags: Research article Source Type: research

Non-traumatic splenic rupture - a rare first presentation of diffuse large B-cell lymphoma and a review of the literature
Cases of non-traumatic splenic rupture are rare and entails a potentially grave medical outcome. Hence, it is important to consider the differential diagnosis of a non-traumatic splenic rupture in patients wit... (Source: BMC Cancer)
Source: BMC Cancer - August 2, 2018 Category: Cancer & Oncology Authors: Kogulakrishnan Kaniappan, Christopher Thiam Seong Lim and Pek Woon Chin Tags: Case report Source Type: research

Trends in incidence, mortality and survival in women with breast cancer from 1985 to 2012 in Granada, Spain: a population-based study
We examined... (Source: BMC Cancer)
Source: BMC Cancer - August 2, 2018 Category: Cancer & Oncology Authors: Jos é Antonio Baeyens-Fernández, Elena Molina-Portillo, Marina Pollán, Miguel Rodríguez-Barranco, Rosario Del Moral, Lorenzo Arribas-Mir, Emilio Sánchez-Cantalejo Ramírez and María-José Sánchez Tags: Research article Source Type: research

Gefitinib provides similar effectiveness and improved safety than erlotinib for east Asian populations with advanced non –small cell lung cancer: a meta-analysis
The first-generation epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib have both been proven effective for treating advanced non –small cell lung cancer (NSCLC), especially in ... (Source: BMC Cancer)
Source: BMC Cancer - August 2, 2018 Category: Cancer & Oncology Authors: Wenxiong Zhang, Yiping Wei, Dongliang Yu, Jianjun Xu and Jinhua Peng Tags: Research article Source Type: research

Removal of pectoral muscle based on topographic map and shape-shifting silhouette
In digital mammography, finding accurate breast profile segmentation of women ’s mammogram is considered a challenging task. The existence of the pectoral muscle may mislead the diagnosis of cancer due to its h... (Source: BMC Cancer)
Source: BMC Cancer - August 1, 2018 Category: Cancer & Oncology Authors: Bushra Mughal, Nazeer Muhammad, Muhammad Sharif, Amjad Rehman and Tanzila Saba Tags: Research article Source Type: research

Once weekly paclitaxel associated with a fixed dose of oral metronomic cyclophosphamide: a dose-finding phase 1 trial
The primary aim of this trial was to determine the recommended phase II dose (RP2D) of weekly paclitaxel (wP) administered in combination with oral metronomic cyclophosphamide (OMC). (Source: BMC Cancer)
Source: BMC Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Diane Pannier, Antoine Adenis, Emilie Bogart, Eric Dansin, St éphanie Clisant-Delaine, Emilie Decoupigny, Anne Lesoin, Eric Amela, Sandrine Ducornet, Jean-Pierre Meurant, Marie-Cécile Le Deley and Nicolas Penel Tags: Research article Source Type: research

Validation of insulin-like growth factor-1 as a prognostic parameter in patients with hepatocellular carcinoma in a European cohort
In hepatocellular carcinoma (HCC), the third leading cause of cancer-related mortality worldwide, the Child-Turcotte-Pugh score (CTP) is one of the most established tools to assess hepatic reserve and determin... (Source: BMC Cancer)
Source: BMC Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Yvonne Huber, Franziska Bierling, Christian Labenz, Sandra Koch, Irene Schmidtmann, Roman Kloeckner, Sebastian Schotten, Tobias Huber, Hauke Lang, Marcus A. Woerns, Peter R. Galle, Arndt Weinmann and Julia Weinmann-Menke Tags: Research article Source Type: research

Cytoplasmic TRAIL-R1 is a positive prognostic marker in PDAC
The death receptors TRAIL-R1 and TRAIL-R2 are frequently overexpressed in cancer and there is an emerging evidence for their important role in malignant progression, also in the case of pancreatic ductal adeno... (Source: BMC Cancer)
Source: BMC Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Jan-Paul Gundlach, Charlotte Hauser, Franka Maria Schlegel, Christine B öger, Christian Röder, Christoph Röcken, Thomas Becker, Jan-Hendrik Egberts, Holger Kalthoff and Anna Trauzold Tags: Research article Source Type: research

Clinical significance of FBXO17 gene expression in high-grade glioma
High-grade gliomas (HGGs) exhibit marked heterogeneity in clinical behavior. The purpose of this study was to identify a novel biomarker that predicts patient outcome, which is helpful in HGG patient management. (Source: BMC Cancer)
Source: BMC Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Di Du, Jian Yuan, Wencai Ma, Jing Ning, John N. Weinstein, Xianrui Yuan, Greg N. Fuller and Yuexin Liu Tags: Research article Source Type: research

An open-label, randomized, phase II trial evaluating the efficacy and safety of standard of care with or without bevacizumab in platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer patients previously treated with bevacizumab for front-line or platinum-sensitive ovarian cancer: rationale, design, and methods of the Japanese Gynecologic Oncology Group study JGOG3023
We present the study rationale and design of the JGOG3023 study, an open-label, parallel-arm, randomized, phase II trial that aimed to assess the efficacy and safety of chemotherapy with or without bevacizumab... (Source: BMC Cancer)
Source: BMC Cancer - July 31, 2018 Category: Cancer & Oncology Authors: Tadahiro Shoji, Shinichi Komiyama, Junzo Kigawa, Hiroshi Tanabe, Kazuyoshi Kato, Hiroaki Itamochi, Hiroyuki Fujiwara, Shoji Kamiura, Tetsutaro Hamano and Toru Sugiyama Tags: Study protocol Source Type: research

Impact of vitamin D on pathological complete response and survival following neoadjuvant chemotherapy for breast cancer: a retrospective study
There has been interest in the potential benefit of vitamin D (VD) to improve breast cancer outcomes. Pre-clinical studies suggest VD enhances chemotherapy-induced cell death. Vitamin D deficiency was associat... (Source: BMC Cancer)
Source: BMC Cancer - July 30, 2018 Category: Cancer & Oncology Authors: Marie Viala, Akiko Chiba, Simon Thezenas, Laure Delmond, Pierre-Jean Lamy, Sarah L. Mott, Mary C. Schroeder, Alexandra Thomas and William Jacot Tags: Research article Source Type: research

Pancreatic adenocarcinoma: insights into patterns of recurrence and disease behavior
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with high metastatic potential. Clinical observations suggest that there is disease heterogeneity among patients with different sit... (Source: BMC Cancer)
Source: BMC Cancer - July 28, 2018 Category: Cancer & Oncology Authors: Ibrahim H. Sahin, Harold Elias, Joanne F. Chou, Marinela Capanu and Eileen M. O ’Reilly Tags: Research article Source Type: research

Cumulative smoking dose affects the clinical outcomes of EGFR-mutated lung adenocarcinoma patients treated with EGFR-TKIs: a retrospective study
Although lung adenocarcinoma with activating epidermal growth factor receptor (EGFR) mutations is common in never smokers, one-third of the patients are ever-smokers. We aimed to investigate the effect of cumu... (Source: BMC Cancer)
Source: BMC Cancer - July 28, 2018 Category: Cancer & Oncology Authors: In Ae Kim, Jong Sik Lee, Hee Joung Kim, Wan Seop Kim and Kye Young Lee Tags: Research article Source Type: research

Classification of gallbladder cancer by assessment of CD8+ TIL and PD-L1 expression
Programmed death ligand 1/2 (PD-L1/PD-L2) expression has been established as a prognostic factor for various solid tumors and as a predictive factor for PD-1 blockade therapy, but scant data on its role in gal... (Source: BMC Cancer)
Source: BMC Cancer - July 28, 2018 Category: Cancer & Oncology Authors: Jianzhen Lin, Junyu Long, Xueshuai Wan, Jingci Chen, Yi Bai, Anqiang Wang, Xiaobo Yang, Yan Wu, Simon C. Robson, Xinting Sang and Haitao Zhao Tags: Research article Source Type: research

Prognosis of ovarian cancer in women with type 2 diabetes using metformin and other forms of antidiabetic medication or statins: a retrospective cohort study
Ovarian cancer is one of the most lethal cancers and women with type 2 diabetes (T2D) have even poorer survival from it. We assessed the prognosis of ovarian cancer in women with type 2 diabetes treated with m... (Source: BMC Cancer)
Source: BMC Cancer - July 28, 2018 Category: Cancer & Oncology Authors: Elina Urpilainen, Mikko Marttila, Ari Hautakoski, Martti Arffman, Reijo Sund, Pirjo Ilanne-Parikka, Reetta Arima, Jenni Kangaskokko, Ulla Puistola, Marianne Hinkula and Esa L äärä Tags: Research article Source Type: research

Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer
Subsyndromal delirium, a condition in which patients exhibit some, but not all, of the symptoms of delirium, can negatively affect the outcomes of patients with cancer. However, the incidence of subsyndromal d... (Source: BMC Cancer)
Source: BMC Cancer - July 27, 2018 Category: Cancer & Oncology Authors: Heesung Hwang, Kwang-Min Lee, Kyung-Lak Son, Dooyoung Jung, Won-Hyoung Kim, Joo-Young Lee, Seong-Ho Kong, Yun-Suhk Suh, Hyuk-Joon Lee, Han-Kwang Yang and Bong-Jin Hahm Tags: Research article Source Type: research

S100A4 suppresses cancer stem cell proliferation via interaction with the IKK/NF- κB signaling pathway
Bladder cancer often recurs due to incomplete elimination of the cancer stem cells (CSCs). Therefore, new strategies targeting bladder CSCs are needed and the aim of this study was to investigate the effect of... (Source: BMC Cancer)
Source: BMC Cancer - July 25, 2018 Category: Cancer & Oncology Authors: Yongtong Zhu, Yao Zhou, Xuan Zhou, Yangchun Guo, Daxiong Huang, Jialin Zhang, Chunyan Wang and Longmei Cai Tags: Research article Source Type: research

Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors
Small intestinal neuroendocrine tumors (SI-NETs) originate from enterochromaffin cells scattered in the intestinal mucosa of the ileum and jejunum. Loss of one copy of chromosome 18 is the most frequent observ... (Source: BMC Cancer)
Source: BMC Cancer - July 25, 2018 Category: Cancer & Oncology Authors: Elham Barazeghi, Surendra Prabhawa, Olov Norl én, Per Hellman, Peter Stålberg and Gunnar Westin Tags: Research article Source Type: research