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BioPro-RCMI-1505 trial: multicenter study evaluating the use of a biodegradable balloon for the treatment of intermediate risk prostate cancer by intensity modulated radiotherapy; study protocol
Prospective trials have demonstrated the advantage of dose-escalated radiotherapy for the biochemical and clinical control of intermediate risk prostate cancer. Dose escalation improves outcomes but increases ... (Source: BMC Cancer)
Source: BMC Cancer - May 16, 2018 Category: Cancer & Oncology Authors: David Pasquier, Emilie Bogart, Fran çois Bonodeau, Thomas Lacornerie, Eric Lartigau and Igor Latorzeff Tags: Study protocol Source Type: research

Patterns of care for anal cancer in the United States - a comparison between academic and community cancer centers
Management of squamous cell carcinoma of the anus (SCCA) is becoming more relevant, as its incidence increases. The purpose of this study was to investigate possible differences in patient population and care ... (Source: BMC Cancer)
Source: BMC Cancer - May 16, 2018 Category: Cancer & Oncology Authors: Victor E. Pricolo, Matteo Bonvini and Carlo F. Abelli Tags: Research article Source Type: research

Knowledge towards cervical cancer prevention and screening practices among women who attended reproductive and child health clinic at Magu district hospital, Lake Zone Tanzania: a cross-sectional study
Cervical cancer is a global leading cause of morbidity and mortality, attributable to the death of approximately 266,000 women every year. Majority (87%) of cervical cancer deaths occur in developing countries... (Source: BMC Cancer)
Source: BMC Cancer - May 16, 2018 Category: Cancer & Oncology Authors: Mabula M. Mabelele, John Materu, Faraja D. Ng ’ida and Michael J. Mahande Tags: Research article Source Type: research

γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport
Ceramide synthesis and metabolism is a promising target in cancer drug development. γ-tocotrienol (GT3), a member of the vitamin E family, orchestrates multiple effects that ensure the induction of apoptosis i... (Source: BMC Cancer)
Source: BMC Cancer - May 16, 2018 Category: Cancer & Oncology Authors: Victoria E. Palau, Kanishka Chakraborty, Daniel Wann, Janet Lightner, Keely Hilton, Marianne Brannon, William Stone and Koyamangalath Krishnan Tags: Research article Source Type: research

Advanced sporadic renal epithelioid angiomyolipoma: case report of an extraordinary response to sirolimus linked to TSC2 mutation
Renal epithelioid angiomyolipomas (EAML) are rare tumors with aggressive behavior. EAML can be sporadic or develop within the tuberous sclerosis complex syndrome, where mutations of TSC1 or TSC2 genes (critical n... (Source: BMC Cancer)
Source: BMC Cancer - May 15, 2018 Category: Cancer & Oncology Authors: Marta Espinosa, Juan Maria Rold án-Romero, Ignacio Duran, Enrique de Álava, María Apellaniz-Ruiz, Alberto Cascón, Carmen Garrigos, Mercedes Robledo and Cristina Rodriguez-Antona Tags: Case report Source Type: research

Low-cost HPV testing and the prevalence of cervical infection in asymptomatic populations in Guatemala
A low cost and accurate method for detecting high-risk (HR) human papillomavirus (HPV) is important to permit HPV testing for cervical cancer prevention. We used a commercially available HPV method (H13, Hybri... (Source: BMC Cancer)
Source: BMC Cancer - May 15, 2018 Category: Cancer & Oncology Authors: Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Jo ël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F. Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Tags: Research article Source Type: research

Clinicopathological features, surgical strategy and prognosis of duodenal gastrointestinal stromal tumors: a series of 300 patients
The relatively low incidence of duodenal gastrointestinal stromal tumors (GISTs) and the unique anatomy make the surgical management and outcomes of this kind of tumor still under debate. Thus, this study aime... (Source: BMC Cancer)
Source: BMC Cancer - May 15, 2018 Category: Cancer & Oncology Authors: Zhen Liu, Gaozan Zheng, Jinqiang Liu, Shushang Liu, Guanghui Xu, Qiao Wang, Man Guo, Xiao Lian, Hongwei Zhang and Fan Feng Tags: Research article Source Type: research

Antiproliferative and apoptotic effect of LY2090314, a GSK-3 inhibitor, in neuroblastoma in vitro
Neuroblastoma (NB) is a devastating disease. Despite recent advances in the treatment of NB, about 60% of high-risk NB will have relapse and therefore long-term event free survival is very minimal. We have rep... (Source: BMC Cancer)
Source: BMC Cancer - May 11, 2018 Category: Cancer & Oncology Authors: Selvi Kunnimalaiyaan, Victoriana K. Schwartz, Iris Alao Jackson, T. Clark Gamblin and Muthusamy Kunnimalaiyaan Tags: Research article Source Type: research

The acceptability of high resolution anoscopy examination in patients attending a tertiary referral centre
High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known abo... (Source: BMC Cancer)
Source: BMC Cancer - May 11, 2018 Category: Cancer & Oncology Authors: Anke De-Masi, Esther Davis, Tamzin Cuming, Noreen Chindawi, Francesca Pesola, Carmelina Cappello, Susan Chambers, Julie Bowring, Adam N. Rosenthal, Peter Sasieni and Mayura Nathan Tags: Research article Source Type: research

Uptake of three doses of HPV vaccine by primary school girls in Eldoret, Kenya; a prospective cohort study in a malaria endemic setting
All women are potentially at risk of developing cervical cancer at some point in their life, yet it is avoidable cause of death among women in Sub- Saharan Africa with a world incidence of 530,000 every year. ... (Source: BMC Cancer)
Source: BMC Cancer - May 11, 2018 Category: Cancer & Oncology Authors: Hillary Mabeya, Sonia Menon, Steven Weyers, Violet Naanyu, Emily Mwaliko, Elijah Kirop, Omenge Orango, Heleen Vermandere and Davy Vanden Broeck Tags: Research article Source Type: research

Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose
Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements. KRAS mutated cancer cells were re... (Source: BMC Cancer)
Source: BMC Cancer - May 11, 2018 Category: Cancer & Oncology Authors: Xiaoshan Zhou, Sophie Curbo, Fuqiang Li, Shuba Krishnan and Anna Karlsson Tags: Research article Source Type: research

Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurat... (Source: BMC Cancer)
Source: BMC Cancer - May 11, 2018 Category: Cancer & Oncology Authors: Vachiranee Limviphuvadh, Chee Seng Tan, Fumikazu Konishi, Piroon Jenjaroenpun, Joy Shengnan Xiang, Yuliya Kremenska, Yar Soe Mu, Nicholas Syn, Soo Chin Lee, Ross A. Soo, Frank Eisenhaber, Sebastian Maurer-Stroh and Wei Peng Yong Tags: Research article Source Type: research

Prognostic value of total number of lymph nodes retrieved differs between left-sided colon cancer and right-sided colon cancer in stage III patients with colon cancer
The consensus is that a minimum of 12 lymph nodes should be analyzed at colectomy for colon cancer. However, right colon cancer and left colon cancer have different characteristics, and this threshold value fo... (Source: BMC Cancer)
Source: BMC Cancer - May 11, 2018 Category: Cancer & Oncology Authors: Lin Yang, Zhenchong Xiong, Qiankun Xie, Wenzhuo He, Shousheng Liu, Pengfei Kong, Chang Jiang, Guifang Guo and Liangping Xia Tags: Research article Source Type: research

VEGF-121 plasma level as biomarker for response to anti-angiogenetic therapy in recurrent glioblastoma
Vascular endothelial growth factor (VEGF) isoforms, particularly the diffusible VEGF-121, could play a major role in the response of recurrent glioblastoma (GB) to anti-angiogenetic treatment with bevacizumab.... (Source: BMC Cancer)
Source: BMC Cancer - May 10, 2018 Category: Cancer & Oncology Authors: Maurizio Martini, Ivana de Pascalis, Quintino Giorgio D ’Alessandris, Vincenzo Fiorentino, Francesco Pierconti, Hany El-Sayed Marei, Lucia Ricci-Vitiani, Roberto Pallini and Luigi Maria Larocca Tags: Research article Source Type: research

Predicting multi-level drug response with gene expression profile in multiple myeloma using hierarchical ordinal regression
Multiple myeloma (MM), like other cancers, is caused by the accumulation of genetic abnormalities. Heterogeneity exists in the patients ’ response to treatments, for example, bortezomib. This urges efforts to i... (Source: BMC Cancer)
Source: BMC Cancer - May 10, 2018 Category: Cancer & Oncology Authors: Xinyan Zhang, Bingzong Li, Huiying Han, Sha Song, Hongxia Xu, Yating Hong, Nengjun Yi and Wenzhuo Zhuang Tags: Research article Source Type: research

The search for a melanoma-tailored chemotherapy in the new era of personalized therapy: a phase II study of chemo-modulating temozolomide followed by fotemustine and a cooperative study of GOIM (Gruppo Oncologico Italia Meridionale)
It is frequently asked whether chemotherapy can still play a role in metastatic melanoma considering the effectiveness of the available drugs today, including antiCTLA4/antiPD1 immunotherapy and antiBRAF/antiM... (Source: BMC Cancer)
Source: BMC Cancer - May 10, 2018 Category: Cancer & Oncology Authors: Michele Guida, Stefania Tommasi, Sabino Strippoli, Maria Iole Natalicchio, Simona De Summa, Rosamaria Pinto, Antonio Cramarossa, Anna Albano, Salvatore Pisconti, Michele Aieta, Ruggiero Ridolfi, Amalia Azzariti, Gabriella Guida, Vito Lorusso and Giusepe C Tags: Research article Source Type: research

18FDG-PET-CT identifies histopathological non-responders after neoadjuvant chemotherapy in locally advanced gastric and cardia cancer: cohort study
Pathologic response to neoadjuvant chemotherapy (neoCTX) is a prognostic factor in many cancer types, and early prediction would help to modify treatment. In patients with gastric and esophagogastric junction ... (Source: BMC Cancer)
Source: BMC Cancer - May 9, 2018 Category: Cancer & Oncology Authors: Paul M. Schneider, Dilmurodjon Eshmuminov, Tamara Rordorf, Diana Vetter, Patrick Veit-Haibach, Achim Weber, Peter Bauerfeind, Panagiotis Samaras and Kuno Lehmann Tags: Research article Source Type: research

Two successful pregnancies following fertility preservation in a patient with anaplastic astrocytoma: a case report
Astrocytomas are the most common malignant glial tumors. With improved prognosis, it is possible for patients to pursue pregnancy post-treatment. However, with potential gonadotoxicity of oncology treatments, ... (Source: BMC Cancer)
Source: BMC Cancer - May 9, 2018 Category: Cancer & Oncology Authors: Alexandra Peyser, Sara L. Bristow and Avner Hershlag Tags: Case report Source Type: research

Clinical decision making in cancer care: a review of current and future roles of patient age
Patient age is among the most controversial patient characteristics in clinical decision making. In personalized cancer medicine it is important to understand how individual characteristics do affect practice ... (Source: BMC Cancer)
Source: BMC Cancer - May 9, 2018 Category: Cancer & Oncology Authors: Eirik Joakim Tranv åg, Ole Frithjof Norheim and Trygve Ottersen Tags: Research article Source Type: research

Phase II study of adjuvant chemotherapy with S1 plus oxaliplatin for Chinese patients with gastric cancer
S-1 plus oxaliplatin(SOX) has been demonstrated to be effective and well tolerated for patients with metastatic gastric cancer. We conducted this phase II study to evaluate the feasibility of SOX as adjuvant c... (Source: BMC Cancer)
Source: BMC Cancer - May 9, 2018 Category: Cancer & Oncology Authors: Guoxiu Wang, Jiuda Zhao, Yan Song, Wen Zhang, Yongkun Sun, Aiping Zhou, Jing Huang, Feng Du and Lin Yang Tags: Research article Source Type: research

Predictors of adverse pathologic features after radical prostatectomy in low-risk prostate cancer
Prostate-specific antigen (PSA) screening more frequently detects early stage prostate cancer (PC). However, adverse pathologic features (APFs) after radical prostatectomy (RP) in low-risk PC occur. Previous r... (Source: BMC Cancer)
Source: BMC Cancer - May 9, 2018 Category: Cancer & Oncology Authors: Jae Won Park, Dong Hoon Koh, Won Sik Jang, Kang Su Cho, Won Sik Ham, Koon Ho Rha, Sung Joon Hong and Young Deuk Choi Tags: Research article Source Type: research

Cancer incidence in Yemen from 1997 to 2011: a report from the Aden cancer registry
This study aims to report on the trend and incidence of cancers in Yemen (Aden) using data from Aden Cancer Registry (ACR), as a population-based cancer registry in Yemen over a period of 15 years (1997 –2011).... (Source: BMC Cancer)
Source: BMC Cancer - May 8, 2018 Category: Cancer & Oncology Authors: Amen Ahmed Bawazir Tags: Research article Source Type: research

Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review
Choriocarcinoma is a rare malignant germ-cell tumour, most commonly found in adult women. It infrequently presents as spontaneous renal haemorrhage (SRH). Genital malformation and SRH secondary to choriocarcin... (Source: BMC Cancer)
Source: BMC Cancer - May 8, 2018 Category: Cancer & Oncology Authors: Yi Li, Gang Chen, Han Chen, Shuang Wen, Chao-yu Xiong, Zi-yi Yang, Yun-xiao Zhu and Nathan Jeffreys Tags: Case report Source Type: research

Korean Society of Coloproctology (KSCP) trial of cONsolidation Chemotherapy for Locally advanced mid or low rectal cancer after neoadjUvant concurrent chemoraDiothErapy: a multicenter, randomized controlled trial (KONCLUDE)
Neoadjuvant chemoradiotherapy (CRT) followed by total mesorectal excision (TME) has been a standard treatment option for locally advanced rectal cancer with improved local control. However, systemic recurrence... (Source: BMC Cancer)
Source: BMC Cancer - May 8, 2018 Category: Cancer & Oncology Authors: Chang Woo Kim, Byung Mo Kang, Ik Yong Kim, Ji Yeon Kim, Sun Jin Park, Won Cheol Park, Ki Beom Bae, Byung-Noe Bae, Seong Kyu Baek, Seung Hyuk Baik, Gyung Mo Son, Yoon Suk Lee and Suk-Hwan Lee Tags: Study protocol Source Type: research

Incidence of breast and colorectal cancer among immigrants in Ontario, Canada: a retrospective cohort study from 2004-2014
The objectives of this study were to describe the incidence of... (Source: BMC Cancer)
Source: BMC Cancer - May 8, 2018 Category: Cancer & Oncology Authors: Jennifer Shuldiner, Ying Liu and Aisha Lofters Tags: Research article Source Type: research

M1 macrophage recruitment correlates with worse outcome in SHH Medulloblastomas
Recent progress in molecular analysis has advanced the understanding of medulloblastoma (MB) and is anticipated to facilitate management of the disease. MB is composed of 4 molecular subgroups: WNT, SHH, Group... (Source: BMC Cancer)
Source: BMC Cancer - May 8, 2018 Category: Cancer & Oncology Authors: Chanhee Lee, Joongyub Lee, Seung Ah Choi, Seung-Ki Kim, Kyu-Chang Wang, Sung-Hye Park, Se Hoon Kim, Ji Yeoun Lee and Ji Hoon Phi Tags: Research article Source Type: research

Metabolomic profiles in breast cancer:a pilot case-control study in the breast cancer family registry
Metabolomics is emerging as an important tool for detecting differences between diseased and non-diseased individuals. However, prospective studies are limited. (Source: BMC Cancer)
Source: BMC Cancer - May 5, 2018 Category: Cancer & Oncology Authors: Marcelle M. Dougan, Yuqing Li, Lisa W. Chu, Robert W. Haile, Alice S. Whittemore, Summer S. Han, Steven C. Moore, Joshua N. Sampson, Irene L. Andrulis, Esther M. John and Ann W. Hsing Tags: Research article Source Type: research

Impact of the treatment of pancreatic exocrine insufficiency on survival of patients with unresectable pancreatic cancer: a retrospective analysis
Malnutrition and weight loss are commonly observed in patients with pancreatic cancer and contribute to poor survival. Pancreatic exocrine insufficiency (PEI), which can be caused by ductal obstruction by a tu... (Source: BMC Cancer)
Source: BMC Cancer - May 5, 2018 Category: Cancer & Oncology Authors: Juan Enrique Dom ínguez-Muñoz, Laura Nieto-Garcia, Javier López-Díaz, Jose Lariño-Noia, Ihab Abdulkader and Julio Iglesias-Garcia Tags: Research article Source Type: research

Neuropilin-1 promotes the oncogenic Tenascin-C/integrin β3 pathway and modulates chemoresistance in breast cancer cells
Neuropilin-1 (NRP-1), a non-tyrosine kinase glycoprotein receptor, is associated with poor prognosis breast cancer, however transcriptomic changes triggered by NRP-1 overexpression and its association with che... (Source: BMC Cancer)
Source: BMC Cancer - May 5, 2018 Category: Cancer & Oncology Authors: Adviti Naik, Aida Al-Yahyaee, Nada Abdullah, Juda-El Sam, Noura Al-Zeheimi, Mahmoud W. Yaish and Sirin A. Adham Tags: Research article Source Type: research

Cytoreductive treatment patterns among US veterans with polycythemia vera
Polycythemia vera (PV) is a myeloproliferative neoplasm associated with increased thrombotic and cardiovascular risk, which are key contributors to patient morbidity and mortality. The Veterans Health Administ... (Source: BMC Cancer)
Source: BMC Cancer - May 4, 2018 Category: Cancer & Oncology Authors: Shreekant Parasuraman, Jingbo Yu, Dilan Paranagama, Sulena Shrestha, Li Wang, Onur Baser and Robyn Scherber Tags: Research article Source Type: research

PET/CT incidental detection of second tumor in patients investigated for pancreatic neoplasms
Positron Emission Tomography/computed tomography (PET/CT) is an imaging technique which has a role in the detection and staging malignancies (both in first diagnosis and follow-up). The finding of an unexpecte... (Source: BMC Cancer)
Source: BMC Cancer - May 4, 2018 Category: Cancer & Oncology Authors: Lucia Moletta, Sergio Bissoli, Alberto Fantin, Nicola Passuello, Michele Valmasoni and Cosimo Sperti Tags: Research article Source Type: research

Chronophin regulates active vitamin B6 levels and transcriptomic features of glioblastoma cell lines cultured under non-adherent, serum-free conditions
The phosphatase chronophin (CIN/PDXP) has been shown to be an important regulator of glioma cell migration and invasion. It has two known substrates: p-Ser3-cofilin, the phosphorylated form of the actin bindin... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2018 Category: Cancer & Oncology Authors: Markus Schulze, Maria Hutterer, Anja Sabo, Sabine Hoja, Julia Lorenz, Tanja Rothhammer-Hampl, Christel Herold-Mende, Lucia Flo ßbach, Camelia Monoranu and Markus J. Riemenschneider Tags: Research article Source Type: research

Vemurafenib in Chinese patients with BRAFV600 mutation –positive unresectable or metastatic melanoma: an open-label, multicenter phase I study
Melanoma is a rare, deadly disease without effective treatment options in China. Vemurafenib is a selective inhibitor of oncogenic BRAFV600 kinase approved in more than 90 countries, based on results obtained pri... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2018 Category: Cancer & Oncology Authors: Lu Si, Xiaoshi Zhang, Zhen Xu, Qiudi Jiang, Lilian Bu, Xuan Wang, Lili Mao, Weijiang Zhang, Nicole Richie and Jun Guo Tags: Research article Source Type: research

The role of vimentin in the tumor marker Nup88-dependent multinucleated phenotype
Nucleoporin Nup88, a component of nuclear pore complexes, is known to be overexpressed in several types of tumor tissue. The overexpression of Nup88 has been reported to promote the early step of tumorigenesis... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2018 Category: Cancer & Oncology Authors: Masaki Makise, Hideaki Nakamura and Akihiko Kuniyasu Tags: Research article Source Type: research

Development and evaluation of oral Cancer quality-of-life questionnaire (QOL-OC)
In this study scales and items for the Oral Cancer Quality-of-life Questionnaire (QOL-OC) were designed and the instrument was evaluated. (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2018 Category: Cancer & Oncology Authors: Min Nie, Chang Liu, Yi-Chen Pan, Chen-Xi Jiang, Bao-Ru Li, Xi-Jie Yu, Xin-Yu Wu and Shu-Ning Zheng Tags: Research article Source Type: research

In vitro antineoplastic effects of auranofin in canine lymphoma cells
The orally available gold complex auranofin (AF) has been used in humans, primarily as an antirheumatic/immunomodulatory agent. It has been safely administered to healthy dogs to establish pharmacokinetic para... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2018 Category: Cancer & Oncology Authors: Hong Zhang, Barbara J. Rose, Alex A. Pyuen and Douglas H. Thamm Tags: Research article Source Type: research

microRNA-451a regulates colorectal cancer proliferation in response to radiation
Colorectal cancer (CRC) is a leading cause of cancer-related death. The biologic response of CRC to standard of care adjuvant therapies such as chemotherapy and radiation are poorly understood. MicroRNAs (miRs... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2018 Category: Cancer & Oncology Authors: Rebecca Ruhl, Shushan Rana, Katherine Kelley, Cristina Espinosa-Diez, Clayton Hudson, Christian Lanciault, Charles R. Thomas Jr, V. Liana Tsikitis and Sudarshan Anand Tags: Research article Source Type: research

Telomere length differences between colorectal polyp subtypes: a colonoscopy-based case-control study
Short telomeres have been associated with increased risk of many cancers, particularly cancers of the gastrointestinal tract including esophagus and stomach. However, the association between telomere length (T... (Source: BMC Cancer)
Source: BMC Cancer - May 2, 2018 Category: Cancer & Oncology Authors: Sheetal Hardikar, Andrea N. Burnett-Hartman, Amanda I. Phipps, Melissa P. Upton, Lee-Ching Zhu and Polly A. Newcomb Tags: Research article Source Type: research

Prognostic value of an automated bone scan index for men with metastatic castration-resistant prostate cancer treated with cabazitaxel
A computer-assisted diagnostic system for analyzing bone scans (BONENAVI) calculates the automated bone scan index (aBSI). Here we evaluated the aBSI as a prognostic imaging biomarker for men with metastatic c... (Source: BMC Cancer)
Source: BMC Cancer - May 2, 2018 Category: Cancer & Oncology Authors: Koichi Uemura, Yasuhide Miyoshi, Takashi Kawahara, Jikuya Ryosuke, Daisuke Yamashita, Shuko Yoneyama, Yumiko Yokomizo, Kazuki Kobayashi, Takeshi Kishida, Masahiro Yao and Hiroji Uemura Tags: Research article Source Type: research

Assessment of the quality of patient-oriented information over internet on testicular cancer
This study aimed to assess the quality and readability of patient education information available on the internet on testicular cancer. (Source: BMC Cancer)
Source: BMC Cancer - May 2, 2018 Category: Cancer & Oncology Authors: Anton S. Prasanth, Umesh Jayarajah, Ranganathan Mohanappirian and Sanjeewa A. Seneviratne Tags: Research article Source Type: research

Limb saving surgery for Ewing ’s sarcoma of the distal tibia: a case report
Ewing ’s sarcoma is a primary malignant tumor of bone occurring mostly in childhood. Few effective reconstruction techniques are available after wide resection of Ewing’s sarcoma at the distal end of the tibia.... (Source: BMC Cancer)
Source: BMC Cancer - May 2, 2018 Category: Cancer & Oncology Authors: Naoki Mizoshiri, Toshiharu Shirai, Ryu Terauchi, Shinji Tsuchida, Yuki Mori, Yusei Katsuyama, Daichi Hayashi, Yoshinobu Oka and Toshikazu Kubo Tags: Case report Source Type: research

LYL1 gene amplification predicts poor survival of patients with uterine corpus endometrial carcinoma: analysis of the Cancer genome atlas data
This study was undertaken to determine wh... (Source: BMC Cancer)
Source: BMC Cancer - May 2, 2018 Category: Cancer & Oncology Authors: Se Ik Kim, Ji Won Lee, Nara Lee, Maria Lee, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Noh Hyun Park, Yong-Sang Song and Jeong-Sun Seo Tags: Research article Source Type: research

Validation of the SNACOR clinical scoring system after transarterial chemoembolisation in patients with hepatocellular carcinoma
Transarterial chemoembolisation is the standard of care for intermediate stage (BCLC B) hepatocellular carcinoma, but it is challenging to decide when to repeat or stop treatment. Here we performed the first e... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2018 Category: Cancer & Oncology Authors: Aline M ähringer-Kunz, Arndt Weinmann, Irene Schmidtmann, Sandra Koch, Sebastian Schotten, Daniel Pinto dos Santos, Michael Bernhard Pitton, Christoph Dueber, Peter Robert Galle and Roman Kloeckner Tags: Research article Source Type: research

Survival and clinical outcomes of patients with melanoma brain metastasis in the era of checkpoint inhibitors and targeted therapies
Melanoma brain metastasis is associated with an extremely poor prognosis, with a median overall survival of 4 –5 months. Since 2011, the overall survival of patients with stage IV melanoma has been significantl... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2018 Category: Cancer & Oncology Authors: Elham Vosoughi, Jee Min Lee, James R. Miller, Mehdi Nosrati, David R. Minor, Roy Abendroth, John W. Lee, Brian T. Andrews, Lewis Z. Leng, Max Wu, Stanley P. Leong, Mohammed Kashani-Sabet and Kevin B. Kim Tags: Research article Source Type: research

Investigation of the SLC22A23 gene in laryngeal squamous cell carcinoma
Laryngeal squamous cell carcinoma (LSCC) is the second most common cancer of the head and neck. In order to identify differentially expressed genes which may have a role in LSCC carcinogenesis, we performed Ge... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2018 Category: Cancer & Oncology Authors: Seda Ekizoglu, Didem Seven, Turgut Ulutin, Jalal Guliyev and Nur Buyru Tags: Research article Source Type: research

Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities
In the United States, race and socioeconomic status are well known predictors of adverse outcomes in several different cancers. Existing evidence suggests that race and socioeconomic status may impact survival... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2018 Category: Cancer & Oncology Authors: Alexander L. Lazarides, Julia D. Visgauss, Daniel P. Nussbaum, Cindy L. Green, Dan G. Blazer III, Brian E. Brigman and William C. Eward Tags: Research article Source Type: research

SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients
Cetuximab, an anti-EGFR monoclonal antibody, is used in combination with chemotherapy in clinic to enhance the outcome in metastatic colorectal cancer (mCRC) patients with only ~  20% response rate. To date onl... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2018 Category: Cancer & Oncology Authors: Zhu Mei, Yang W. Shao, Peinan Lin, Xiaomin Cai, Biao Wang, Yan Ding, Xiangyuan Ma, Xue Wu, Yewei Xia, Dongqin Zhu, Yongqian Shu, Zan Fu and Yanhong Gu Tags: Research article Source Type: research

FOLFOX activity in a rare case of metastatic colonic adenocarcinoma of the tongue: a case report
Adenocarcinomas of the oral cavity are rare neoplasms, and only four cases of primary colonic adenocarcinoma of the tongue have ever been described in literature. Very few information about chemotherapy sensit... (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2018 Category: Cancer & Oncology Authors: Clizia Zichi, Marco Tampellini, Marcello Tucci, Cristina Sonetto, Chiara Baratelli, Maria P. Brizzi and Giorgio V. Scagliotti Tags: Case report Source Type: research

Amphotericin B suppresses M2 phenotypes and B7-H1 expression in macrophages to prevent Raji cell proliferation
Macrophages in the tumor microenvironment play a critical role in tumorigenesis and anti-cancer drug resistance. Burkitt ’s lymphoma (BL) is a B-cell non-Hodgkin’s lymphoma with dense macrophage infiltration. H... (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2018 Category: Cancer & Oncology Authors: Jing Zhang, Dongqing Cao, Shuangquan Yu, Lingchao Chen, Daolin Wei, Chang Shen, Lin Zhuang, Qian Wang, Xiaoping Xu and Yin Tong Tags: Research article Source Type: research

Reduction of MHC-I expression limits T-lymphocyte-mediated killing of Cancer-initiating cells
It has been proposed that cancer establishment, maintenance, and recurrence may be attributed to a unique population of tumor cells termed cancer-initiating cells (CICs) that may include characteristics of put... (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2018 Category: Cancer & Oncology Authors: Brian J. Morrison, Jason C. Steel and John C. Morris Tags: Research article Source Type: research