Genetic alterations and their therapeutic implications in epithelial ovarian cancer
Genetic alterations for epithelial ovarian cancer are insufficiently characterized. Previous studies are limited regarding included histologies, gene numbers, copy number variant (CNV) detection, and interpret... (Source: BMC Cancer)
Source: BMC Cancer - May 4, 2021 Category: Cancer & Oncology Authors: Nina Lapke, Chien-Hung Chen, Ting-Chang Chang, Angel Chao, Yen-Jung Lu, Chyong-Huey Lai, Kien Thiam Tan, Hua-Chien Chen, Hsiao-Yun Lu and Shu-Jen Chen Tags: Research article Source Type: research

The value of complete remission according to positron emission tomography prior to autologous stem cell transplantation in lymphoma: a population-based study showing improved outcome
Chimeric antigen-receptor T-cell and bispecific antibody therapies will likely necessitate a reconsideration of the role of autologous stem-cell transplantation (ASCT) in lymphoma. Patients who are likely to p... (Source: BMC Cancer)
Source: BMC Cancer - May 4, 2021 Category: Cancer & Oncology Authors: Kristina Noring, Mattias Carlsten, Kristina Sonnevi and Bj örn Engelbrekt Wahlin Tags: Research article Source Type: research

Clinical significance and risk factors of International Society of Urological Pathology (ISUP) grade upgrading in prostate cancer patients undergoing robot-assisted radical prostatectomy
The objective of this study is to investigate the clinical significance and risk factors of upgrading in the International Society of Urological Pathology (ISUP) Grade Group System in men undergoing robot-assi... (Source: BMC Cancer)
Source: BMC Cancer - May 4, 2021 Category: Cancer & Oncology Authors: Yuta Takeshima, Yuta Yamada, Taro Teshima, Tetsuya Fujimura, Shigenori Kakutani, Yuji Hakozaki, Naoki Kimura, Yoshiyuki Akiyama, Yusuke Sato, Taketo Kawai, Daisuke Yamada and Haruki Kume Tags: Research Source Type: research

Prognostic impact of additive chemotherapy after curative resection of metachronous colorectal liver metastasis: a single-centre retrospective study
A prognostic benefit of additive chemotherapy in patients following resection of metachronous colorectal liver metastases (CRLM) remains controversial. Therefore, the goal of this retrospective study was to in... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2021 Category: Cancer & Oncology Authors: Matthias Kelm, Julia Schollbach, Friedrich Anger, Armin Wiegering, Ingo Klein, Christoph-Thomas Germer, Nicolas Schlegel, Volker Kunzmann and Stefan L öb Tags: Research article Source Type: research

Increased risk of breast cancer-specific mortality among cancer survivors who developed breast cancer as a second malignancy
Cancer survivors who develop breast cancer as a second malignancy (BCa-2) are common. Yet, little is known about the prognosis of BCa-2 compared to first primary breast cancer (BCa-1). (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2021 Category: Cancer & Oncology Authors: Chengshi Wang, Kejia Hu, Lei Deng, Wei He, Fang Fang, Rulla M. Tamimi and Donghao Lu Tags: Research article Source Type: research

Normal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma
Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma (CTCL) that transforms from mature, skin-homing T cells and progresses during the early stages in the skin. The role of the skin microenvironment i... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2021 Category: Cancer & Oncology Authors: Syed Jafar Mehdi, Andrea Moerman-Herzog and Henry K. Wong Tags: Research article Source Type: research

Study protocol of the LARK (TROG 17.03) clinical trial: a phase II trial investigating the dosimetric impact of Liver Ablative Radiotherapy using Kilovoltage intrafraction monitoring
Stereotactic Ablative Body Radiotherapy (SABR) is a non-invasive treatment which allows delivery of an ablative radiation dose with high accuracy and precision. SABR is an established treatment for both primar... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2021 Category: Cancer & Oncology Authors: Yoo Young Dominique Lee, Doan Trang Nguyen, Trevor Moodie, Ricky O ’Brien, Anne McMaster, Andrew Hickey, Nicole Pritchard, Per Poulsen, Elizaveta Mitkina Tabaksblat, Britta Weber, Esben Worm, David Pryor, Julie Chu, Nicholas Hardcastle, Jeremy Booth, Va Tags: Study protocol Source Type: research

Robot-assisted thoracic surgery versus video-assisted thoracic surgery for lung lobectomy or segmentectomy in patients with non-small cell lung cancer: a meta-analysis
It remains no clear conclusion about which is better between robot-assisted thoracic surgery (RATS) and video-assisted thoracic surgery (VATS) for the treatment of patients with non-small cell lung cancer (NSC... (Source: BMC Cancer)
Source: BMC Cancer - May 3, 2021 Category: Cancer & Oncology Authors: Jianglei Ma, Xiaoyao Li, Shifu Zhao, Jiawei Wang, Wujia Zhang and Guangyuan Sun Tags: Research Source Type: research

Assessment of retroperitoneal lymph node status in locally advanced cervical cancer
This study aimed to explore the choice of these assessment methods. (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2021 Category: Cancer & Oncology Authors: Wei Li, Li Xiong, Qiaoling Zhu, Hong Lu, Meiling Zhong, Meirong Liang, Wei Jiang, Yanan Wang and Wei Cheng Tags: Research article Source Type: research

Are socio-economic inequalities in breast cancer survival explained by peri-diagnostic factors?
Patients living in more deprived localities have lower cancer survival in England, but the role of individual health status at diagnosis and the utilisation of primary health care in explaining these different... (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2021 Category: Cancer & Oncology Authors: Laura M. Woods, Bernard Rachet, Melanie Morris, Krishnan Bhaskaran and Michel P. Coleman Tags: Research article Source Type: research

Role of Synaptophysin, Chromogranin and CD56 in adenocarcinoma and squamous cell carcinoma of the lung lacking morphological features of neuroendocrine differentiation: a retrospective large-scale study on 1170 tissue samples
Synaptophysin, chromogranin and CD56 are recommended markers to identify pulmonary tumors with neuroendocrine differentiation. Whether the expression of these markers in pulmonary adenocarcinoma and pulmonary ... (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2021 Category: Cancer & Oncology Authors: Katharina Kriegsmann, Christiane Zgorzelski, Thomas Muley, Petros Christopoulos, Michael Thomas, Hauke Winter, Martin Eichhorn, Florian Eichhorn, Moritz von Winterfeld, Esther Herpel, Benjamin Goeppert, Albrecht Stenzinger, Felix J. F. Herth, Arne Warth a Tags: Research article Source Type: research

Whole genome sequencing in oncology: using scenario drafting to explore future developments
In oncology, Whole Genome Sequencing (WGS) is not yet widely implemented due to uncertainties such as the required infrastructure and expertise, costs and reimbursements, and unknown pan-cancer clinical utilit... (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2021 Category: Cancer & Oncology Authors: Michiel van de Ven, Martijn J. H. G. Simons, Hendrik Koffijberg, Manuela A. Joore, Maarten J. IJzerman, Valesca P. Ret èl and Wim H. van Harten Tags: Research article Source Type: research

How to manage synchronous endometrial and ovarian cancer patients?
We aimed to evaluate the prognosis in patients with synchronous endometrial and ovarian cancer (SEOC) by comparing the differences between double primary cancer (DPC) and metastatic cancer (MC). (Source: BMC Cancer)
Source: BMC Cancer - May 1, 2021 Category: Cancer & Oncology Authors: Wonkyo Shin, Sang-Yoon Park, Sokbom Kang, Myong Cheol Lim and Sang-Soo Seo Tags: Research article Source Type: research

Survival of colorectal cancer patients in Brunei Darussalam: comparison between 2002 –09 and 2010–17
Colorectal cancer (CRC) is a major cause of cancer-related mortality worldwide. It is the second leading cause of cancer death in men and women in Brunei Darussalam in 2017, posing a major burden on society. (Source: BMC Cancer)
Source: BMC Cancer - April 30, 2021 Category: Cancer & Oncology Authors: Shirley H. F. Lee, Hanif Abdul Rahman, Nadiah Abidin, Sok King Ong, Elvynna Leong and Lin Naing Tags: Research Source Type: research

Screening for distress, related problems and perceived need for psycho-oncological support in head and neck squamous cell carcinoma (HNSCC) patients: a retrospective cohort study
In different cancer entities, several studies have shown the adverse effects of cancer on mental health, psychological well-being and the increased risk of high emotional distress in cancer patients. This stud... (Source: BMC Cancer)
Source: BMC Cancer - April 30, 2021 Category: Cancer & Oncology Authors: V. Kunz, G. Wichmann, A. Lehmann-Laue, A. Mehnert-Theuerkauf, A. Dietz and S. Wiegand Tags: Research Source Type: research

Prognostic value of ubiquitin E2 UBE2W and its correlation with tumor-infiltrating immune cells in breast cancer
Ubiquitin-conjugating enzyme E2W (UBE2W) is a protein-coding gene that has an important role in ubiquitination and may be vital in the repair of DNA damage. However, studies on the prognostic value of UBE2W and i... (Source: BMC Cancer)
Source: BMC Cancer - April 30, 2021 Category: Cancer & Oncology Authors: Yan Yuan, Wei-Wei Xiao, Wei-Hao Xie, Rong-Zhen Li and Yuan-Hong Gao Tags: Research Source Type: research

Clinical significance of tumor-stroma ratio in head and neck cancer: a systematic review and meta-analysis
The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer. (Source: BMC Cancer)
Source: BMC Cancer - April 30, 2021 Category: Cancer & Oncology Authors: Alhadi Almangush, Rasheed Omobolaji Alabi, Giuseppe Troiano, Ricardo D. Coletta, Tuula Salo, Matti Pirinen, Antti A. M äkitie and Ilmo Leivo Tags: Research Source Type: research

Efficacy and acquired resistance for EGFR-TKI plus thoracic SBRT in patients with advanced EGFR-mutant non –small-cell lung cancer: a propensity-matched retrospective study
This retrospective study aimed to evaluate the efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) with stereotactic body radiation therapy (SBRT) and to elucidate potential m... (Source: BMC Cancer)
Source: BMC Cancer - April 30, 2021 Category: Cancer & Oncology Authors: Xia Wang, Zhimin Zeng, Jing Cai, Peng Xu, Pingan Liang, Yuxi Luo and Anwen Liu Tags: Research article Source Type: research

Patterns of surveillance for late effects of BCR-ABL tyrosine kinase inhibitors in survivors of pediatric Philadelphia chromosome positive leukemias
Targeted anticancer therapies such as BCR-ABL tyrosine kinase inhibitors (TKIs) have improved outcomes for chronic myeloid leukemia (CML) and Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph  +... (Source: BMC Cancer)
Source: BMC Cancer - April 29, 2021 Category: Cancer & Oncology Authors: Stephanie M. Smith, Himalee S. Sabnis, Rebecca Williamson Lewis, Karen E. Effinger, John Bergsagel, Briana Patterson, Ann Mertens, Kathleen M. Sakamoto, Lidia Schapira and Sharon M. Castellino Tags: Research article Source Type: research

High HSPA8 expression predicts adverse outcomes of acute myeloid leukemia
Acute myeloid leukemia (AML) remains one of the most common hematological malignancies, posing a serious challenge to human health. HSPA8 is a chaperone protein that facilitates proper protein folding. It cont... (Source: BMC Cancer)
Source: BMC Cancer - April 29, 2021 Category: Cancer & Oncology Authors: Jun Li and Zheng Ge Tags: Research Source Type: research

MACE-Seq-based coding RNA and TrueQuant-based small RNA profile in breast cancer: tumor-suppressive miRNA-1275 identified as a novel marker
Disruption of cellular processes in the breast by abnormally expressed miRNA is characterized to develop cancer. We aimed to identify the differential expression of small RNAs (sRNAs) and mRNAs in formalin-fix... (Source: BMC Cancer)
Source: BMC Cancer - April 29, 2021 Category: Cancer & Oncology Authors: Sevan Omer Majed and Suhad Asad Mustafa Tags: Research Source Type: research

Active surveillance for thyroid Cancer: a qualitative study of barriers and facilitators to implementation
The 2015 American Thyroid Association guidelines supported active surveillance (AS) as a strategy for managing select low-risk thyroid cancers. Data examining physicians ’ attitudes about the acceptability of t... (Source: BMC Cancer)
Source: BMC Cancer - April 28, 2021 Category: Cancer & Oncology Authors: Catherine B. Jensen, Megan C. Saucke and Susan C. Pitt Tags: Research Source Type: research

Is PSA density of the peripheral zone as a useful predictor for prostate cancer in patients with gray zone PSA levels?
Serum prostate-specific antigen (PSA) is widely used in screening tests for prostate cancer. As the low specificity of PSA results in unnecessary and invasive prostate biopsies, we evaluated the clinical signi... (Source: BMC Cancer)
Source: BMC Cancer - April 28, 2021 Category: Cancer & Oncology Authors: Jaegeun Lee, Seung Woo Yang, Long Jin, Chung Lyul Lee, Ji Yong Lee, Ju Hyun Shin, Jae Sung Lim and Ki Hak Song Tags: Research article Source Type: research

Primary effusion lymphoma occurring in the setting of transplanted patients: a systematic review of a rare, life-threatening post-transplantation occurrence
Primary effusion lymphoma is a rare, aggressive large B-cell lymphoma strictly linked to infection by Human Herpes virus 8/Kaposi sarcoma-associated herpes virus. In its classic form, it is characterized by bo... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2021 Category: Cancer & Oncology Authors: Magda Zanelli, Francesca Sanguedolce, Maurizio Zizzo, Andrea Palicelli, Maria Chiara Bassi, Giacomo Santandrea, Giovanni Martino, Alessandra Soriano, Cecilia Caprera, Matteo Corsi, Stefano Ricci, Linda Ricci and Stefano Ascani Tags: Research article Source Type: research

Prognostic value of inflammation-based indices in patients with resected hepatocellular carcinoma
As is well recognized that inflammation plays a crucial role in the genesis and progression of various cancer. Here we investigate the prognostic value of a novel index: the combination of neutrophil to lympho... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2021 Category: Cancer & Oncology Authors: Weihao Kong, Mingwei Yang, Jianfeng Zhang, Ya Cheng, Tianxing Dai, Jian Zhang, Guoying Wang and Jianlin Zhang Tags: Research article Source Type: research

Locoregional recurrence via mucus-mediated extension following lung resection for mucinous tumors
Clinically, locoregional recurrences following mucinous tumor resection are often experienced. However, it remains unclear whether mucinous tumors directly affect local recurrence or not, and if so, the mechan... (Source: BMC Cancer)
Source: BMC Cancer - April 27, 2021 Category: Cancer & Oncology Authors: Yo Kawaguchi, Jun Hanaoka, Yasuhiko Ohshio, Keigo Okamoto, Ryosuke Kaku, Kazuki Hayashi, Takuya Shiratori, Akira Akazawa and Mitsuaki Ishida Tags: Research Source Type: research

Pressurized intra-peritoneal aerosol chemotherapy (PIPAC): increased intraperitoneal pressure does not affect distribution patterns but leads to deeper penetration depth of doxorubicin in a sheep model
Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC) is an innovative treatment against peritoneal carcinomatosis. Doxorubicin is a common intra-venous chemotherapy used for peritoneal carcinomatosis and ... (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2021 Category: Cancer & Oncology Authors: Myriam Mimouni, Christophe Richard, Pierre Adenot, Martine Letheule, Anne Tarrade, Olivier Sandra, Mich èle Dahirel, Thomas Lilin, Benoit Lecuelle, Valérie Gélin, Julien Cohen, Arnaud Fauconnier, François Vialard, Cyrille Huchon and Pascale Chavatte-P Tags: Research article Source Type: research

Distinct diagnostic and prognostic values of Glypicans gene expression in patients with hepatocellular carcinoma
In our current work, we aimed to investigate the expressions of glypican (GPC) family genes at the mRNA level and assess their prognostic significances in patients with hepatocellular carcinoma (HCC). (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2021 Category: Cancer & Oncology Authors: Jian-Yao Wang, Xiang-Kun Wang, Guang-Zhi Zhu, Xin Zhou, Jun Yao, Xiao-Peng Ma, Bin Wang and Tao Peng Tags: Research article Source Type: research

Dedicated MRI staging versus surgical staging of peritoneal metastases in colorectal cancer patients considered for CRS-HIPEC; the DISCO randomized multicenter trial
Selecting patients with peritoneal metastases from colorectal cancer (CRCPM) who might benefit from cytoreductive surgery followed by hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is challenging. Compu... (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2021 Category: Cancer & Oncology Authors: M. P. Engbersen, C. J. V. Rijsemus, J. Nederend, A. G. J. Aalbers, I. H. J. T. de Hingh, V. Retel, D. M. J. Lambregts, E. J. R. J. Van der Hoeven, D. Boerma, M. J. Wiezer, M. De Vries, E. V. E. Madsen, A. R. M. Brandt-Kerkhof, S. Van Koeverden, P. R. De R Tags: Study protocol Source Type: research

Development and validation of nomograms for predicting axillary non-SLN metastases in breast cancer patients with 1 –2 positive sentinel lymph node macro-metastases: a retrospective analysis of two independent cohorts
It is reported that appropriately 50% of early breast cancer patients with 1 –2 positive sentinel lymph node (SLN) micro-metastases could not benefit from axillary lymph node dissection (ALND) or breast-conserv... (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2021 Category: Cancer & Oncology Authors: Yang Yu, Zhijun Wang, Zhongyin Wei, Bofan Yu, Peng Shen, Yuan Yan and Wei You Tags: Research article Source Type: research

Identification of novel prognostic biomarkers by integrating multi-omics data in gastric cancer
Gastric cancer is a fatal gastrointestinal cancer with high morbidity and poor prognosis. The dismal 5-year survival rate warrants reliable biomarkers to assess and improve the prognosis of gastric cancer. Dis... (Source: BMC Cancer)
Source: BMC Cancer - April 26, 2021 Category: Cancer & Oncology Authors: Nannan Liu, Yun Wu, Weipeng Cheng, Yuxuan Wu, Liguo Wang and Liwei Zhuang Tags: Research Source Type: research

Identification of NTRK3 as a potential prognostic biomarker associated with tumor mutation burden and immune infiltration in bladder cancer
Bladder cancer (BLCA) is a common malignant tumor of urinary system with high morbidity and mortality. In recent years, immunotherapy has played a significant role in the treatment of BLCA. Tumor mutation burd... (Source: BMC Cancer)
Source: BMC Cancer - April 24, 2021 Category: Cancer & Oncology Authors: Zhao Zhang, Yongbo Yu, Pengfei Zhang, Guofeng Ma, Mingxin Zhang, Ye Liang, Wei Jiao and Haitao Niu Tags: Research Source Type: research

Global, regional, and national mortality trends of female breast cancer by risk factor, 1990 –2017
Female breast cancer (FBC) is a malignancy involving multiple risk factors and has imposed heavy disease burden on women. We aim to analyze the secular trends of mortality rate of FBC according to its major ri... (Source: BMC Cancer)
Source: BMC Cancer - April 24, 2021 Category: Cancer & Oncology Authors: Hui Liu, Wenjie Shi, Zhi Jin, Rui Zhuo, Jie Dong, Qiufeng Lao, Shengle Li and Weiyi Pang Tags: Research Source Type: research

Efficacy and safety of apatinib in the treatment of osteosarcoma: a single-arm meta-analysis among Chinese patients
Osteosarcoma is a relatively rare malignant tumor with a high incidence in young people. The development of tyrosine kinase inhibitors has brought the treatment of osteosarcoma into a new stage. Apatinib, a ty... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2021 Category: Cancer & Oncology Authors: Hui Yao, Xuyu Chen and Xiaodong Tan Tags: Research article Source Type: research

Nomograms predicting the overall survival and cancer-specific survival of patients with stage IIIC1 cervical cancer
To explore the factors that affect the prognosis of overall survival (OS) and cancer-specific survival (CSS) of patients with stage IIIC1 cervical cancer and establish nomogram models to predict this prognosis. (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2021 Category: Cancer & Oncology Authors: Yifan Feng, Ye Wang, Yangqin Xie, Shuwei Wu, Yuyang Li and Min Li Tags: Research Source Type: research

Bioinformatics analysis of mRNA and miRNA microarray to identify the key miRNA-mRNA pairs in cisplatin-resistant ovarian cancer
Ovarian cancer (OC) is a gynecological malignancy with the highest mortality rate. Cisplatin (DDP) based chemotherapy is a standard strategy for ovarian cancer. Despite good response rates for initial chemothe... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2021 Category: Cancer & Oncology Authors: Bai Xue, Shupeng Li, Xianyu Jin and Lifeng Liu Tags: Research Source Type: research

A high level of lncFGD5-AS1 inhibits epithelial-to-Mesenchymal transition by regulating the miR-196a-5p/SMAD6/BMP axis in gastric Cancer
This study found a new lncRNA, FGD5-AS1, which can inhibit EMT process, proliferation, and metastasis in vitr... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2021 Category: Cancer & Oncology Authors: Lin Liu, Cheng Zhang, Jizhao Wang, Xu Liu, Hangying Qu, Guangjian Zhang, Ting Liang, Jiansheng Wang and Jia Zhang Tags: Research article Source Type: research

A genomic-clinicopathologic Nomogram for the preoperative prediction of lymph node metastasis in gastric cancer
Preoperative evaluation of lymph node (LN) state is of pivotal significance for informing therapeutic decisions in gastric cancer (GC) patients. However, there are no non-invasive methods that can be used to p... (Source: BMC Cancer)
Source: BMC Cancer - April 23, 2021 Category: Cancer & Oncology Authors: Xin Zhong, Feichao Xuan, Yun Qian, Junhai Pan, Suihan Wang, Wenchao Chen, Tianyu Lin, Hepan Zhu, Xianfa Wang and Guanyu Wang Tags: Research article Source Type: research

Women ’s experiences in a community-based screen-and-treat cervical cancer prevention program in rural Malawi: a qualitative study
Malawi has the world ’s highest cervical cancer incidence and mortality due to high rate of HIV coupled with inadequate screening and treatment services. The country’s cervical cancer control program uses visua... (Source: BMC Cancer)
Source: BMC Cancer - April 22, 2021 Category: Cancer & Oncology Authors: Fan Lee, Agatha Bula, John Chapola, Clement Mapanje, Billy Phiri, Nenani Kamtuwange, Mercy Tsidya, Jennifer Tang and Lameck Chinula Tags: Research article Source Type: research

Clinical outcomes observation in stage IIB –IIIB cervical cancer treated by adjuvant surgery following concurrent chemoradiotherapy
To explore the feasibility of adjuvant surgery following concurrent chemoradiation therapy (CCRT) in stage IIB –IIIB (according to FIGO staging of 2009) cervical cancer and analyze risk factors of recurrence af... (Source: BMC Cancer)
Source: BMC Cancer - April 21, 2021 Category: Cancer & Oncology Authors: Yong Li, Zhiying Chen, Xiang Wang, Xiumei Li, Jie Zhou and Yongchun Zhang Tags: Research article Source Type: research

Immunological effect of irreversible electroporation on hepatocellular carcinoma
This study intends to investigate the immunological effects of tumor ablation with irreversible electroporation (IRE). (Source: BMC Cancer)
Source: BMC Cancer - April 21, 2021 Category: Cancer & Oncology Authors: Xiaoxia Guo, Fang Du, Qin Liu, Yan Guo, Qingbing Wang, Wei Huang, Zhongmin Wang, Xiaoyi Ding and Zhiyuan Wu Tags: Research article Source Type: research

Intrinsic and extrinsic apoptosis responses in leukaemia cells following daunorubicin treatment
Daunorubicin is used clinically in the treatment of myeloma, acute lymphatic and myelocytic leukaemia. The toxic lesions caused by daunorubicin induce various modes of cell death, including apoptosis. Apoptosi... (Source: BMC Cancer)
Source: BMC Cancer - April 21, 2021 Category: Cancer & Oncology Authors: Hussain Mubarak Al-Aamri, Helen R. Irving, Christopher Bradley and Terri Meehan-Andrews Tags: Research Source Type: research

Comparison of breast cancer surrogate subtyping using a closed-system RT-qPCR breast cancer assay and immunohistochemistry on 100 core needle biopsies with matching surgical specimens
Routine clinical management of breast cancer (BC) currently depends on surrogate subtypes according to estrogen- (ER) and progesterone (PR) receptor, Ki-67, and HER2-status. However, there has been growing dem... (Source: BMC Cancer)
Source: BMC Cancer - April 21, 2021 Category: Cancer & Oncology Authors: Slavica Janeva, Toshima Z. Parris, Salmir Nasic, Shahin De Lara, Karolina Larsson, Riccardo A. Audisio, Roger Olofsson Bagge and Anik ó Kovács Tags: Research Source Type: research

Clinically relevant dual probe difference specimen imaging (DDSI) protocol for freshly resected breast cancer specimen staining
Re-excision rates following breast conserving surgery (BCS) remain as high as ~  35%, with positive margins detected during follow-up histopathology. Additional breast cancer resection surgery is not only taxin... (Source: BMC Cancer)
Source: BMC Cancer - April 21, 2021 Category: Cancer & Oncology Authors: Broderick J. House, Marcus J. Kwon, Jasmin M. Schaefer, Connor W. Barth, Allison Solanki, Scott C. Davis and Summer L. Gibbs Tags: Research Source Type: research

A composite biomarker of neutrophil-lymphocyte ratio and hemoglobin level correlates with clinical response to PD-1 and PD-L1 inhibitors in advanced non-small cell lung cancers
Immune checkpoint inhibitors (ICIs) have been incorporated into various clinical oncology guidelines for systemic treatment of advanced non-small cell lung cancers (aNSCLC). However, less than 50% (and 20%) of... (Source: BMC Cancer)
Source: BMC Cancer - April 21, 2021 Category: Cancer & Oncology Authors: Kristin L. Ayers, Meng Ma, Gaspard Debussche, David Corrigan, Jonathan McCafferty, Kyeryoung Lee, Scott Newman, Xiang Zhou, Fred R. Hirsch, Philip C. Mack, Jane J. Liu, Eric E. Schadt, Rong Chen and Shuyu D. Li Tags: Research Source Type: research

A nomogram to predict lymph node metastasis risk for early esophageal squamous cell carcinoma
A nomogram was developed to predict lymph node metastasis (LNM) for patients with early-stage esophageal squamous cell carcinoma (ESCC). (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2021 Category: Cancer & Oncology Authors: Xiaofeng Duan, Xiaobin Shang, Jie Yue, Zhao Ma, Chuangui Chen, Peng Tang, Hongjing Jiang and Zhentao Yu Tags: Research article Source Type: research

Active behavior of triple-negative breast cancer with adipose tissue invasion: a single center and retrospective review
Interactions between adipocyte and breast cancer (BC) cells have yet to be fully elucidated. Here we investigated the prognostic impact of marginal adipose tissue invasion in both luminal breast cancer (HR+/HE... (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2021 Category: Cancer & Oncology Authors: Junzo Yamaguchi, Hiroki Moriuchi, Takashi Ueda, Yujo Kawashita, Takanori Hazeyama, Masaki Tateishi, Shigehisa Aoki, Kazuyoshi Uchihashi and Mikio Nakamura Tags: Research article Source Type: research

Impact of the preoperative prognostic nutritional index as a predictor for postoperative complications after resection of locally recurrent rectal cancer
Local recurrence is common after curative resections for rectal cancer. Surgical intervention is among the best treatment choices. However, achieving a negative resection margin often requires extensive pelvic... (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2021 Category: Cancer & Oncology Authors: Masakatsu Paku, Mamoru Uemura, Masatoshi Kitakaze, Shiki Fujino, Takayuki Ogino, Norikatsu Miyoshi, Hidekazu Takahashi, Hirofumi Yamamoto, Tsunekazu Mizushima, Yuichiro Doki and Hidetoshi Eguchi Tags: Research article Source Type: research

Comprehensive analyses of competing endogenous RNA networks reveal potential biomarkers for predicting hepatocellular carcinoma recurrence
This study aimed to investigate the mechanism underlying the progression of HCC a... (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2021 Category: Cancer & Oncology Authors: Ping Yan, Zuotian Huang, Tong Mou, Yunhai Luo, Yanyao Liu, Baoyong Zhou, Zhenrui Cao and Zhongjun Wu Tags: Research Source Type: research

Extra-abdominal desmoid tumor fibromatosis: a multicenter EMSOS study
Extra-abdominal desmoid tumor fibromatosis (DTF) is a rare, locally aggressive soft tissue tumour. The best treatment modality for this patient cohort is still object of debate. (Source: BMC Cancer)
Source: BMC Cancer - April 20, 2021 Category: Cancer & Oncology Authors: Pierluigi Cuomo, Guido Scoccianti, Alberto Schiavo, Valentina Tortolini, Catrin Wigley, Francesco Muratori, Davide Matera, Mariia Kukushkina, Philipp Theodor Funovics, Marie-Theres Lingitz, Reinhard Windhager, Sander Dijkstra, Jorrit Jasper, Daniel A. M Tags: Research Source Type: research