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Body mass index and lung cancer risk: a pooled analysis based on nested case-control studies from four cohort studies
We examined the association between BMI and lung cancer risk in a pooled analysis based on nested case-control studies from four ... (Source: BMC Cancer)
Source: BMC Cancer - February 23, 2018 Category: Cancer & Oncology Authors: Harinakshi Sanikini, Jian-Min Yuan, Lesley M. Butler, Woon-Puay Koh, Yu-Tang Gao, Annika Steffen, Mattias Johansson, Paolo Vineis, Gary E. Goodman, Matt J. Barnett, Rayjean J. Hung, Chu Chen and Isabelle St ücker Tags: Research article Source Type: research

LGR5 overexpression confers poor relapse-free survival in breast cancer patients
Cancer stem cells (CSCs) are believed to promote the malignant transformation of breast cancer via multiple signaling pathways, including the Wnt/ β-catenin pathway. Leucine-rich repeat-containing G protein-cou... (Source: BMC Cancer)
Source: BMC Cancer - February 22, 2018 Category: Cancer & Oncology Authors: Ming-Feng Hou, Po-Ming Chen and Pei-Yi Chu Tags: Research article Source Type: research

A novel combined systemic inflammation-based score can predict survival of intermediate-to-advanced hepatocellular carcinoma patients undergoing transarterial chemoembolization
There is currently limited information regarding the prognostic ability of the dNLR-PNI (the combination of the derived neutrophil-to-lymphocyte ratio [dNLR] and prognostic nutritional index [PNI]) for hepatoc... (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Chang Liu, Lei Li, Wu-sheng Lu, Hua Du, Lu-nan Yan, Tian-fu Wen, Wu-ran Wei, Li Jiang and Ming-qing Xu Tags: Research article Source Type: research

Real life patterns of care and progression free survival in metastatic renal cell carcinoma patients: retrospective analysis of cross-sectional data
The objective of this study was to describe treatment pathways, safety, drug costs... (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Rana Maroun, Laura Mitrofan, Laure Benjamin, Gaelle Nachbaur, Franck Maunoury, Philippe Le Jeunne and Isabelle Durand-Zaleski Tags: Research article Source Type: research

Occurrence of colorectal aberrant crypt foci depending on age and dietary patterns of patients
Aberrant crypt foci (ACF) are commonly considered the early pre-cancerous lesions that can progress to colorectal cancer (CRC). The available literature data reveal that age, dietary factors and lifestyle can ... (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Marek Kowalczyk, Marcin Or łowski, Piotr Siermontowski, Dariusz Mucha, Krzysztof Zinkiewicz, Waldemar Kurpiewski, Ewa Zieliński, Iwona Kowalczyk and Agnieszka Pedrycz Tags: Research article Source Type: research

A randomised trial to compare cognitive outcome after gamma knife radiosurgery versus whole brain radiation therapy in patients with multiple brain metastases: research protocol CAR-study B
Gamma Knife radiosurgery (GKRS) is increasingly applied in patients with multiple brain metastases and is expected to have less adverse effects in cognitive functioning than whole brain radiation therapy (WBRT... (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Wietske C. M. Schimmel, Eline Verhaak, Patrick E. J. Hanssens, Karin Gehring and Margriet M. Sitskoorn Tags: Study protocol Source Type: research

Successful treatment with pazopanib plus PD-1 inhibitor and RAK cells for advanced primary hepatic angiosarcoma: a case report
Primary hepatic angiosarcoma (PHA) is a rare and aggressive solid tumor, with high rates of local recurrence and distant metastasis, and poor prognosis. There are no established treatment guidelines for PHA. (Source: BMC Cancer)
Source: BMC Cancer - February 21, 2018 Category: Cancer & Oncology Authors: Yu Qiao, Jihong Yang, Lili Liu, Yixin Zeng, Jie Ma, Jing Jia, Li Zhang, Xiaoguang Li, Peihong Wu, Wenchao Wang, Dongge Liu, Huan Chen, Yunbo Zhao, Huan Xi and Yao Wang Tags: Case report Source Type: research

Glycolysis is essential for chemoresistance induced by transient receptor potential channel C5 in colorectal cancer
Elevated intracellular Ca2+ ([Ca2+] i ) level could lead to [Ca2+] i overload and promote apoptosis via different pathways. In our prev... (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Teng Wang, Kuan Ning, Xu Sun, Chun Zhang, Lin-fang Jin and Dong Hua Tags: Research article Source Type: research

Inhibition of autophagy sensitizes cancer cells to Photofrin-based photodynamic therapy
Accumulating evidence suggest that autophagy plays a pivotal role in various anticancer therapies, including photodynamic therapy (PDT), acting as a pro-death or pro-survival mechanism in a context-dependent m... (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Antoni Domagala, Joanna Stachura, Magdalena Gabrysiak, Angelika Muchowicz, Radoslaw Zagozdzon, Jakub Golab and Malgorzata Firczuk Tags: Research article Source Type: research

Metastatic cardiac tumors: from clinical presentation through diagnosis to treatment
To evaluate the prevalence of metastatic tumors involving the myocardium and study their presentation in order to increase awareness to their existence. (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Ivana Burazor, Sarit Aviel-Ronen, Massimo Imazio, Orly Goitein, Marina Perelman, Natalia Shelestovich, Ninoslav Radovanovic, Vladimir Kanjuh, Iris Barshack and Yehuda Adler Tags: Research article Source Type: research

Breast cancer subtype discordance: impact on post-recurrence survival and potential treatment options
Recent studies have shown that breast cancer subtype can change from the primary tumour to the recurrence. Discordance between primary and recurrent breast cancer has implications for further treatment and ult... (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2018 Category: Cancer & Oncology Authors: Peter F. McAnena, James AL Brown, A. Ramli, C. Curran, C. Malone, R. McLaughlin, K. Barry, Brown JAL and M. J. Kerin Tags: Research article Source Type: research

Preliminary qualification of a novel, hypoxic-based radiologic signature for trans-arterial chemoembolization in hepatocellular carcinoma
Survival advantage following trans-arterial chemoembolization (TACE) is variable in patients with hepatocellular carcinoma (HCC). We combined pre-TACE radiologic features to derive a novel prognostic signature... (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2018 Category: Cancer & Oncology Authors: David J. Pinato, Madhava Pai, Isabella Reccia, Markand Patel, Alexandros Giakoustidis, Georgios Karamanakos, Azelea Rushd, Shiraz Jamshaid, Alberto Oldani, Glenda Grossi, Mario Pirisi, Paul Tait and Rohini Sharma Tags: Research article Source Type: research

RECORD-4 multicenter phase 2 trial of second-line everolimus in patients with metastatic renal cell carcinoma: Asian versus non-Asian population subanalysis
RECORD-4 assessed everolimus in patients with metastatic renal cell carcinoma (mRCC) who progressed after 1 prior anti-vascular endothelial growth factor (VEGF) or cytokine and reinforced the clinical benefit ... (Source: BMC Cancer)
Source: BMC Cancer - February 17, 2018 Category: Cancer & Oncology Authors: Lin Yang, Anna Alyasova, Dingwei Ye, Antonia Ridolfi, Luca Dezzani and Robert J. Motzer Tags: Research article Source Type: research

Radiotherapy related skin toxicity (RAREST-01): Mepitel ® film versus standard care in patients with locally advanced head-and-neck cancer
The aim of the present trial is to investigate a new option of skin protection in order to reduce the rate of grade  ≥ 2 skin toxicity in patients receiving radiotherapy alone or radiochemotherapy for locally a... (Source: BMC Cancer)
Source: BMC Cancer - February 17, 2018 Category: Cancer & Oncology Authors: Carlos Narvaez, Claudia Doemer, Christian Idel, Cornelia Setter, Denise Olbrich, Zaza Ujmajuridze, Jesper Hansen Carl and Dirk Rades Tags: Study protocol Source Type: research

Fertility preservation healthcare circuit and networks in cancer patients worldwide: what are the issues?
This article describes the FP services and strategy cur... (Source: BMC Cancer)
Source: BMC Cancer - February 17, 2018 Category: Cancer & Oncology Authors: Kathleen Melan, Frederic Amant, Jacqueline Veronique-Baudin, Clarisse Joachim and Eustase Janky Tags: Review Source Type: research

A prospective study to investigate the role of serial serum mesothelin in monitoring mesothelioma
Radiological monitoring of malignant pleural mesothelioma (MPM) using modified RECIST criteria is limited by low sensitivity and inter-observer variability. Serial serum mesothelin measurement has shown utilit... (Source: BMC Cancer)
Source: BMC Cancer - February 17, 2018 Category: Cancer & Oncology Authors: Duneesha de Fonseka, David T. Arnold, Louise Stadon, Anna Morley, Emma Keenan, Michael Darby, Lynne Armstrong, Paul Virgo and Nick A. Maskell Tags: Research article Source Type: research

Treatment of upper tract urothelial carcinoma with ureteroscopy and thulium laser: a retrospective single center study
Treatment with the combination of ureteroscopy and thulium laser ablation may provide an alternative to radical nephroureterectomy (RNU) for patients with upper tract urothelial carcinoma (UTUC). The purpose o... (Source: BMC Cancer)
Source: BMC Cancer - February 17, 2018 Category: Cancer & Oncology Authors: Jin Wen, Zhi G. Ji and Han Z. Li Tags: Research article Source Type: research

The T790M resistance mutation in EGFR is only found in cfDNA from erlotinib-treated NSCLC patients that harbored an activating EGFR mutation before treatment
Lung cancer patients with an activating mutation in the EGFR (epidermal growth factor receptor) can develop resistance to erlotinib treatment, which is often mediated by the T790M resistance mutation in EGFR. ... (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2018 Category: Cancer & Oncology Authors: Christina Demuth, Anne Tranberg Madsen, Britta Weber, Lin Wu, Peter Meldgaard and Boe Sandahl Sorensen Tags: Research article Source Type: research

Physical activity and risk of testicular cancer: a systematic review
Physical activity has been implicated as a risk factor in the development of testicular cancer (TC), but the relationship remains controversial. This systematic review pooled available evidence regarding this ... (Source: BMC Cancer)
Source: BMC Cancer - February 14, 2018 Category: Cancer & Oncology Authors: Stephanie Huang, Virginia Signal, Diana Sarfati, Caroline Shaw, James Stanley, Katherine McGlynn and Jason Gurney Tags: Research article Source Type: research

Transarterial chemoembolization (TACE) using mitomycin and lipiodol with or without degradable starch microspheres for hepatocellular carcinoma: comparative study
To evaluate survival data and local tumor control after transarterial chemoembolization in two groups with different embolization protocols for the treatment of HCC patients. (Source: BMC Cancer)
Source: BMC Cancer - February 14, 2018 Category: Cancer & Oncology Authors: Tatjana Gruber-Rouh, Cornelia Schmitt, Nagy N. N. Naguib, N. A. Nour-Eldin, Katrin Eichler, Martin Beeres and Thomas J. Vogl Tags: Research article Source Type: research

Lack of association between cigarette smoking and Epstein Barr virus reactivation in the nasopharynx in people with elevated EBV IgA antibody titres
Subjects with elevated Epstein-Barr virus (EBV) immunoglobulin A (IgA) titers have a higher risk of developing nasopharyngeal carcinoma (NPC), indicating that reactivation of EBV in the local mucosa might be i... (Source: BMC Cancer)
Source: BMC Cancer - February 14, 2018 Category: Cancer & Oncology Authors: Yufeng Chen, Yifei Xu, Weilin Zhao, Xue Xiao, Xiaoying Zhou, Longde Lin, Tingting Huang, Jian Liao, Yancheng Li, Xiaoyun Zeng, Guangwu Huang, Weimin Ye and Zhe Zhang Tags: Research article Source Type: research

Serum and blood based biomarkers for lung cancer screening: a systematic review
Lung cancer is the second most common cancer and the leading cause of cancer death for both men and women. Although low-dose CT (LDCT) is recommended for lung cancer screening in high-risk populations and may ... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Gavin C. W. Chu, Kim Lazare and Frank Sullivan Tags: Research article Source Type: research

Treatment using oxaliplatin and S-1 adjuvant chemotherapy for pathological stage III gastric cancer: a multicenter phase II study (TOSA trial) protocol
Recent studies demonstrated the efficacy of S-1-based adjuvant chemotherapy administered for six months after curative surgery for stage III gastric cancer; however, it is unproven whether this type of combina... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Tsutomu Namikawa, Hiromichi Maeda, Hiroyuki Kitagawa, Koji Oba, Akihito Tsuji, Takaki Yoshikawa, Michiya Kobayashi and Kazuhiro Hanazaki Tags: Study protocol Source Type: research

HIPECT4: multicentre, randomized clinical trial to evaluate safety and efficacy of Hyperthermic intra-peritoneal chemotherapy (HIPEC) with Mitomycin C used during surgery for treatment of locally advanced colorectal carcinoma
Local relapse and peritoneal carcinomatosis (PC) for pT4 colon cancer is estimated in 15,6% and 36,7% for 12 months and 36 months from surgical resection respectively, achieving a 5 years overall survival of 6... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: A. Arjona-S ánchez, P. Barrios, E. Boldo-Roda, B. Camps, J. Carrasco-Campos, V. Concepción Martín, A. García-Fadrique, A. Gutiérrez-Calvo, R. Morales, G. Ortega-Pérez, E. Pérez-Viejo, A. Prada-Villaverde, J. Torres-Melero, E. Vicente, P. Villarejo- Tags: Study protocol Source Type: research

Correlation between global methylation level of peripheral blood leukocytes and serum C reactive protein level modified by MTHFR polymorphism: a cross-sectional study
Chronic inflammatory conditions are associated with higher tumor incidence through epigenetic and genetic alterations. Here, we focused on an association between an inflammation marker, C-reactive-protein (CRP... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Masanori Nojima, Motoki Iwasaki, Yoshio Kasuga, Shiro Yokoyama, Hiroshi Onuma, Hideki Nishimura, Ritsu Kusama, Teruhiko Yoshida and Shoichiro Tsugane Tags: Research article Source Type: research

Male BRCA mutation carriers: clinical characteristics and cancer spectrum
Mutations in BRCA1 and BRCA2 (BRCA1/2) genes are associated with an increased risk of breast and ovarian cancers in women. The cancer characteristics of men with BRCA1/2 mutations are less well studied. This stud... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Mohammed Ibrahim, Siddhartha Yadav, Foluso Ogunleye and Dana Zakalik Tags: Research article Source Type: research

Real-life feasibility of home-based pulmonary rehabilitation in chemotherapy-treated patients with thoracic cancers: a pilot study
Patients with advanced lung cancer (LC) or malignant pleural mesothelioma (MPM) exhibit limitation of exercise capacities and alteration of quality of life (QoL) induced by cancer and its treatment. Few studie... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Cecile Olivier, Jean-Marie Grosbois, Alexis B. Cortot, Sophie Peres, Christophe Heron, Julie Delourme, Marianne Gierczynski, Anne Hoorelbeke, Arnaud Scherpereel and Olivier Le Rouzic Tags: Research article Source Type: research

Prognostic impact of presumed breast or ovarian cancer among patients with unfavorable-subset cancer of unknown primary site
The clinical utility and prognostic impact of presumed primary breast or ovarian cancer among patients with an unfavorable subset of cancer of unknown primary site (CUP) remains unclear. We aimed to evaluate t... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Makoto Kodaira, Kan Yonemori, Tatsunori Shimoi, Akihiko Yoshida, Masayuki Yoshida, Atsuko Kitano, Akihiko Shimomura, Mayu Yunokawa, Chikako Shimizu, Yuichi Takiguchi, Yasuhiro Fujiwara and Kenji Tamura Tags: Research article Source Type: research

Genetic determinants of sporadic breast cancer in Sri Lankan women
While a range of common genetic variants have been identified to be associated with risk of sporadic breast cancer in several Western studies, little is known about their role in South Asian populations. Our o... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Nirmala Dushyanthi Sirisena, Adebowale Adeyemo, Anchala I. Kuruppu, Nilaksha Neththikumara, Nilakshi Samaranayake and Vajira H. W. Dissanayake Tags: Research article Source Type: research

High-dose thiotepa-related neurotoxicity and the role of tramadol in children
The objective was to assess the incidence of NAE related to h... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2018 Category: Cancer & Oncology Authors: Christophe Maritaz, Francois Lemare, Agnes Laplanche, Sylvie Demirdjian, Dominique Valteau-Couanet and Christelle Dufour Tags: Research article Source Type: research

Comparison of first-line chemotherapy regimens for ovarian carcinosarcoma: a single institution case series and review of the literature
The optimal first-line chemotherapy for ovarian carcinosarcoma has not yet been determined. We therefore sought to determine the progression-free survival (PFS) and overall survival (OS) for patients with ovar... (Source: BMC Cancer)
Source: BMC Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Melissa Brackmann, Marina Stasenko, Shitanshu Uppal, Jake Erba, R. Kevin Reynolds and Karen McLean Tags: Research article Source Type: research

Characteristics of people living in Italy after a cancer diagnosis in 2010 and projections to 2020
Estimates of cancer prevalence are widely based on limited duration, often including patients living after a cancer diagnosis made in the previous 5 years and less frequently on complete prevalence (i.e., incl... (Source: BMC Cancer)
Source: BMC Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Stefano Guzzinati, Saverio Virdone, Roberta De Angelis, Chiara Panato, Carlotta Buzzoni, Riccardo Capocaccia, Silvia Francisci, Anna Gigli, Manuel Zorzi, Giovanna Tagliabue, Diego Serraino, Fabio Falcini, Claudia Casella, Antonio Giampiero Russo, Fabrizio Tags: Research article Source Type: research

Factors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort
In addition to tumor characteristics and lifestyle factors, cancer relapses are often related to the risk of death but have not been jointly studied. We investigate the prognostic factors of recurrent events a... (Source: BMC Cancer)
Source: BMC Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Alexandre Lafourcade, Mathilde His, Laura Baglietto, Marie-Christine Boutron-Ruault, Laure Dossus and Virginie Rondeau Tags: Research article Source Type: research

Preclinical evaluation and reverse phase protein Array-based profiling of PI3K and MEK inhibitors in endometrial carcinoma in vitro
The phosphoinositide-3-kinase (PI3K) pathway is the most commonly activated pathway in cancers due to mutations at multiple nodes and loss of PTEN. Furthermore, in endometrial cancer (EC), PI3K and RAS/RAF/MEK... (Source: BMC Cancer)
Source: BMC Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Ozlem Aslan, Mattia Cremona, Clare Morgan, Lydia W. Cheung, Gordon B. Mills and Bryan T. Hennessy Tags: Research article Source Type: research

Prevalence of Mouse Mammary Tumor Virus (MMTV)-like sequences in human breast cancer tissues and adjacent normal breast tissues in Saudi Arabia
Breast cancer is considered the most common cancer in women worldwide and is the leading cause of cancer mortality. Sequences similar to Mouse Mammary Tumor Virus (MMTV) were detected in human breast cancer in... (Source: BMC Cancer)
Source: BMC Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Reem Al Dossary, Khaled R. Alkharsah and Haitham Kussaibi Tags: Research article Source Type: research

Is RNASEL:p.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations?
Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in families, including genetic modifiers of risk. We considered genetic modifiers of risk for carriers ... (Source: BMC Cancer)
Source: BMC Cancer - February 8, 2018 Category: Cancer & Oncology Authors: T ú Nguyen-Dumont, Zhi L. Teo, Fleur Hammet, Alexis Roberge, Maryam Mahmoodi, Helen Tsimiklis, Daniel J. Park, Bernard J. Pope, Andrew Lonie, Miroslav K. Kapuscinski, Khalid Mahmood, David E. Goldgar, Graham G. Giles, Ingrid Winship, John L. Hopper and M Tags: Research article Source Type: research

Diethylnitrosamine induces lung adenocarcinoma in FVB/N mouse
Diethylnitrosamine is a well known carcinogen that induces cancers of various organs in mice and rats. Using FVB/N mouse strain, here we show that diethylnitrosamine induces primarily lung adenocarcinomas with... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2018 Category: Cancer & Oncology Authors: Zsolt Mervai, Krisztina Egedi, Ilona Kovalszky and Korn élia Baghy Tags: Research article Source Type: research

Factors predicting patient satisfaction in women with advanced breast cancer: a prospective study
The present study (1) examined patient satisfaction with care over the first year following the diagnosis of advanced breast cancer and (2) tested if unmet health system and information needs, physical symptom... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2018 Category: Cancer & Oncology Authors: Wendy W. T. Lam, Ava Kwong, Dacita Suen, Janice Tsang, Inda Soong, Tze Kok Yau, Winnie Yeo, Joyce Suen, Wing Ming Ho, Ka Yan Wong, Wing Kin Sze, Alice W. Y. Ng and Richard Fielding Tags: Research article Source Type: research

Trends in molecular subtypes of breast cancer: description of incidence rates between 2007 and 2012 from three French registries
The incidence and incidence trends of breast cancer according to molecular subtype are unknown at a population level in France. The registry data enables this study and may give this information, that is cruci... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2018 Category: Cancer & Oncology Authors: Marion Cortet, Aur élie Bertaut, Florence Molinié, Simona Bara, Françoise Beltjens, Charles Coutant and Patrick Arveux Tags: Research article Source Type: research

Prognostic implications of polycomb proteins ezh2, suz12, and eed1 and histone modification by H3K27me3 in sarcoma
Polycomb repressive complex 2 (PRC2; formed by EZH2, SUZ12, and EED protein subunits) and PRC1 (BMI1 protein) induce gene silencing through histone modification by H3K27me3. In the present study, we characteri... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2018 Category: Cancer & Oncology Authors: Yong Jin Cho, Soo Hee Kim, Eun Kyung Kim, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Sung-Taek Jung & hellip; Tags: Research article Source Type: research

Frequency of the acquired resistant mutation T790 M in non-small cell lung cancer patients with active exon 19Del and exon 21 L858R: a systematic review and meta-analysis
Although EGFR-TKI is the preferred treatment for NSCLC patients with sensitive mutations, subsequent drug resistance is almost inevitable. The specific mechanisms of EGFR-TKI drug resistance can be identified ... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2018 Category: Cancer & Oncology Authors: Zan-Feng Wang, Sheng-Xiang Ren, Wei Li and Guang-Hui Gao Tags: Research article Source Type: research

Impact of body mass index on surgical outcomes of gastric cancer
The association between body mass index (BMI) and clinical outcomes of gastric cancer were still under debate. The aim of the present study was to investigate the impact of BMI on intraoperative conditions, po... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2018 Category: Cancer & Oncology Authors: Fan Feng, Gaozan Zheng, Xiaohua Guo, Zhen Liu, Guanghui Xu, Fei Wang, Qiao Wang, Man Guo, Xiao Lian and Hongwei Zhang Tags: Research article Source Type: research

HtrA1 as a promising tissue marker in cancer: a meta-analysis
This study reports the results of a meta-analysis that was perform... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2018 Category: Cancer & Oncology Authors: Emma Altobelli, Paolo Matteo Angeletti, Manrico Morroni and Valerio Filippo Profeta Tags: Research article Source Type: research

PD-L1 expression in malignant salivary gland tumors
Programmed death-1 ligand-1 (PD-L1) an important cancer biomarker that can suppress the immune system and its high expression is often reported to be related with increased tumor aggressiveness in some cancers... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2018 Category: Cancer & Oncology Authors: Koji Harada, Tarannum Ferdous and Yoshiya Ueyama Tags: Research article Source Type: research

Evolution of quality of life in patients with breast cancer during the first year of follow-up in Morocco
The objective of this study is to assess the evolution of the patient ’s quality of life with breast cancer in Morocco after ... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2018 Category: Cancer & Oncology Authors: B. M. Traore, S. El Fakir, H. Charaka, N. Benaicha, A. Najdi, A. Zidouh, M. Bennani, H. Errihani, N. Mellass, A. Benider, R. Bekkali and C. Nejjari Tags: Research article Source Type: research

A simple filter model to guide the allocation of healthcare resources for improving the treatment of depression among cancer patients
Depression is highly prevalent yet often poorly detected and treated among cancer patients. In light of the move towards evidence-based healthcare policy, we have developed a simple tool that can assist policy... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2018 Category: Cancer & Oncology Authors: Robert W. Sanson-Fisher, Natasha E. Noble, Andrew M. Searles, Simon Deeming, Rochelle E. Smits, Christopher J. Oldmeadow and Jamie Bryant Tags: Research article Source Type: research

Randomised controlled trial protocol (GRIP study): examining the effect of involvement of a general practitioner and home care oncology nurse after a cancer diagnosis on patient reported outcomes and healthcare utilization
Due to the ageing population and improving diagnostics and treatments, the number of cancer patients and cancer survivors is increasing. Policymakers, patients and professionals advocate a transfer of (part of... (Source: BMC Cancer)
Source: BMC Cancer - February 5, 2018 Category: Cancer & Oncology Authors: I. A. A. Perfors, C. W. Helsper, E. A. Noteboom, E. van der Wall, N. J. de Wit and A. M. May Tags: Study protocol Source Type: research

Pre-operative and intra-operative detection of axillary lymph node metastases in 108 patients with invasive lobular breast cancer undergoing mastectomy
Despite the recent changes in the treatment of the axilla in selected breast cancer patient, positive sentinel lymph node (SLN) in patients undergoing mastectomy still necessitates axillary lymph node dissecti... (Source: BMC Cancer)
Source: BMC Cancer - February 5, 2018 Category: Cancer & Oncology Authors: Jerica Novak, Nikola Besic, Radan Dzodic, Barbara Gazic and Andrej Vogrin Tags: Research article Source Type: research

Clinical characteristics of distal gastric cancer in young adults from Northeastern Brazil
It has been suggested that distal gastric carcinoma (GC) in younger patients has a more aggressive outcome than in older patients, however this is a controversial issue. The aim of this study was to compare cl... (Source: BMC Cancer)
Source: BMC Cancer - February 5, 2018 Category: Cancer & Oncology Authors: Manuel B. Braga-Neto, Jessica Gomes Carneiro, Alzira M. de Castro Barbosa, Igor S. Silva, Danielle C. Maia, Felipe S. Maciel, Rafael Jorge Alves de Alc ântara, Paulo Roberto L. Vasconscelos and Lucia L. B. C. Braga Tags: Research article Source Type: research

Performance of a prognostic 31-gene expression profile in an independent cohort of 523 cutaneous melanoma patients
This study eva... (Source: BMC Cancer)
Source: BMC Cancer - February 5, 2018 Category: Cancer & Oncology Authors: Jonathan S. Zager, Brian R. Gastman, Sancy Leachman, Rene C. Gonzalez, Martin D. Fleming, Laura K. Ferris, Jonhan Ho, Alexander R. Miller, Robert W. Cook, Kyle R. Covington, Kristen Meldi-Plasseraud, Brooke Middlebrook, Lewis H. Kaminester, Anthony Greisi Tags: Research article Source Type: research