Patient and tumour characteristics associated with inclusion in Cancer patient pathways in Norway in 2015 –2016
Cancer patient pathways (CPPs) were implemented in 2015 to reduce waiting time, regional variation in waiting time, and to increase the predictability of cancer care for the patients. The aims of this study we... (Source: BMC Cancer)
Source: BMC Cancer - May 30, 2020 Category: Cancer & Oncology Authors: Yngvar Nilssen, Odd Terje Brustugun, Morten Tandberg Eriksen, Erik Skaaheim Haug, Bj ørn Naume and Bjørn Møller Tags: Research article Source Type: research

Components of metabolic syndrome in patients with multiple myeloma and smoldering multiple myeloma
The prevalences of diabetes mellitus and hypertension, both of which are components of metabolic syndrome, are known to be increased among patients with multiple myeloma (MM), but remain undetermined among pat... (Source: BMC Cancer)
Source: BMC Cancer - May 30, 2020 Category: Cancer & Oncology Authors: Efrat Markus, Svetlana Trestman, Yael Cohen, Yoel Angel, Yael Sofer, Moshe Mittelman, Irit Avivi, Naftali Stern and Elena Izkhakov Tags: Research article Source Type: research

A scientometric analysis of neuroblastoma research
Thousands of research articles on neuroblastoma have been published over the past few decades; however, the heterogeneity and variable quality of scholarly data may challenge scientists or clinicians to survey... (Source: BMC Cancer)
Source: BMC Cancer - May 29, 2020 Category: Cancer & Oncology Authors: Illya Martynov, Jessica Klima-Frysch and Joachim Schoenberger Tags: Research article Source Type: research

Prognostic role of alpha-fetoprotein in patients with hepatocellular carcinoma treated with repeat transarterial chemoembolisation
Repeat transarterial chemoembolisation (rTACE) is often required for hepatocellular carcinoma (HCC) to achieve disease control, however, current practice guidelines regarding treatment allocation vary signific... (Source: BMC Cancer)
Source: BMC Cancer - May 29, 2020 Category: Cancer & Oncology Authors: Gauri Mishra, Anouk Dev, Eldho Paul, Wa Cheung, Jim Koukounaras, Ashu Jhamb, Ben Marginson, Beng Ghee Lim, Paul Simkin, Adina Borsaru, James Burnes, Mark Goodwin, Vivek Ramachandra, Manfred Spanger, John Lubel, Paul Gow & hellip; Tags: Research article Source Type: research

Systematic screening as a tool for individualized rehabilitation following primary breast cancer treatment: study protocol for the ReScreen randomized controlled trial
It is well known that women suffer from negative consequences following breast cancer (BC) treatment and that their largely varying needs for rehabilitation are often unmet. Up to 43% of these women are at ris... (Source: BMC Cancer)
Source: BMC Cancer - May 29, 2020 Category: Cancer & Oncology Authors: U. Olsson M öller, L. Rydén and M. Malmström Tags: Study protocol Source Type: research

NORAD01-GRECCAR16 multicenter phase III non-inferiority randomized trial comparing preoperative modified FOLFIRINOX without irradiation to radiochemotherapy for resectable locally advanced rectal cancer (intergroup FRENCH-GRECCAR- PRODIGE trial)
Preoperative radiochemotherapy (RCT) is recommended in France prior to total mesorectal excision in patients with mid or low locally advanced rectal cancer (LARC) (cT3/T4 and/or N+) because it has been shown t... (Source: BMC Cancer)
Source: BMC Cancer - May 29, 2020 Category: Cancer & Oncology Authors: Antoine Brouquet, Jean-Baptiste Bachet, Florence Huguet, Mehdi Karoui, Pascal Artru, Charles Sabbagh, J érémie H. Lefèvre, Dewi Vernerey, Christophe Mariette, Eric Vicaut and Stephane Benoist Tags: Study protocol Source Type: research

Cancer staging in individuals with a severe psychiatric illness: a cross-sectional study using population-based cancer registry data
Advanced cancer stage at diagnosis may explain high cancer mortality among patients with a severe psychiatric illness (SPI). Studies to date investigating advanced stage cancer at diagnosis as a potential expl... (Source: BMC Cancer)
Source: BMC Cancer - May 27, 2020 Category: Cancer & Oncology Authors: Alyson L. Mahar, Paul Kurdyak, Timothy P. Hanna, Natalie G. Coburn and Patti A. Groome Tags: Research article Source Type: research

An isolated vaginal metastasis from intestinal signet ring cell carcinoma: a case report and literature review
Isolated vaginal metastases from intestinal signet ring cell carcinoma are extremely rare. There are no reported cases in the domestic or foreign literature. The characteristics of such cases of metastasis rem... (Source: BMC Cancer)
Source: BMC Cancer - May 27, 2020 Category: Cancer & Oncology Authors: Xiao Dan Zhu, Jin Wang, Qin Han You and Tian An Jiang Tags: Case report Source Type: research

Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study
Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asian... (Source: BMC Cancer)
Source: BMC Cancer - May 27, 2020 Category: Cancer & Oncology Authors: Hind El yacoubi, Mohamed Lemine Sow, Fouad Kettani, Lamia Gamra, Amina Mestari, Lamia Jabri, Ibrahim Elghissassi and Hassan Errihani Tags: Research article Source Type: research

The structural effect of high intensity ultrasound on peritoneal tissue: a potential vehicle for targeting peritoneal metastases
High-intensity ultrasound (HIUS) has been increasingly investigated as a possible tool in the treatment of multiple tumor entities. However, there is only little knowledge on the effect of HIUS on the peritone... (Source: BMC Cancer)
Source: BMC Cancer - May 27, 2020 Category: Cancer & Oncology Authors: Agata Mikolajczyk, Tanja Khosrawipour, Joanna Kulas, Pawel Migdal, Mohamed Arafkas, Jakub Nicpon and Veria Khosrawipour Tags: Research article Source Type: research

Discrimination between clinical significant and insignificant prostate cancer with apparent diffusion coefficient – a systematic review and meta analysis
Prostate MRI has become a corner stone in diagnosis of prostate cancer (PC). Diffusion weighted imaging and the apparent diffusion coefficient (ADC) can be used to reflect tumor microstructure. The present ana... (Source: BMC Cancer)
Source: BMC Cancer - May 27, 2020 Category: Cancer & Oncology Authors: Hans-Jonas Meyer, Andreas Wienke and Alexey Surov Tags: Research article Source Type: research

Elderly women ’s experiences of self-sampling for HPV testing
Self-sampling for HPV testing, as an alternative to the conventional speculum based sampling, is highly acceptable to women of screening ages. The aim of this study was to describe older women ’s (60 to 75 year... (Source: BMC Cancer)
Source: BMC Cancer - May 26, 2020 Category: Cancer & Oncology Authors: Ruth S. Hermansson, Matts Olovsson, Catharina Gustavsson and Annika Kristina Lindstr öm Tags: Research article Source Type: research

Damage-associated molecular patterns (DAMPs) related to immunogenic cell death are differentially triggered by clinically relevant chemotherapeutics in lung adenocarcinoma cells
Chemotherapeutics can stimulate immune antitumor response by inducing immunogenic cell death (ICD), which is activated by Damage-Associated Molecular Patterns (DAMPs) like the exposure of calreticulin (CRT) on... (Source: BMC Cancer)
Source: BMC Cancer - May 26, 2020 Category: Cancer & Oncology Authors: Jos é Ignácio Gonzalez Solari, Eduardo Filippi-Chiela, Emily Salles Pilar, Vitória Nunes, Esteban Alberto Gonzalez, Fabrício Figueiró, Cristiano Feijó Andrade and Fábio Klamt Tags: Research article Source Type: research

The prognostic value of IDO expression in solid tumors: a systematic review and meta-analysis
Indoleamine 2,3-dioxygenase (IDO) is a rate-limiting enzyme in the metabolism of tryptophan into kynurenine. It is considered to be an immunosuppressive molecule that plays an important role in the development... (Source: BMC Cancer)
Source: BMC Cancer - May 26, 2020 Category: Cancer & Oncology Authors: Sen Wang, Jia Wu, Han Shen and Junjun Wang Tags: Research article Source Type: research

Hyperfunction of CD4 CD25 regulatory T cells in de novo acute myeloid leukemia
Acute myeloid leukemia (AML) is a common hematopoietic malignancy that has a high relapse rate, and the number of regulatory T cells (Tregs) in AML patients is significantly increased. The aim of this study wa... (Source: BMC Cancer)
Source: BMC Cancer - May 26, 2020 Category: Cancer & Oncology Authors: Yuling Wan, Congxiao Zhang, Yingxi Xu, Min Wang, Qing Rao, Haiyan Xing, Zheng Tian, Kejing Tang, Yingchang Mi, Ying Wang and Jianxiang Wang Tags: Research article Source Type: research

CT-based radiomics scores predict response to neoadjuvant chemotherapy and survival in patients with gastric cancer
Neoadjuvant chemotherapy is a promising treatment option for potential resectable gastric cancer, but patients ’ responses vary. We aimed to develop and validate a radiomics score (rad_score) to predict treatme... (Source: BMC Cancer)
Source: BMC Cancer - May 25, 2020 Category: Cancer & Oncology Authors: Kai-Yu Sun, Hang-Tong Hu, Shu-Ling Chen, Jin-Ning Ye, Guang-Hua Li, Li-Da Chen, Jian-Jun Peng, Shi-Ting Feng, Yu-Jie Yuan, Xun Hou, Hui Wu, Xin Li, Ting-Fan Wu, Wei Wang and Jian-Bo Xu Tags: Research article Source Type: research

Independence of HIF1a and androgen signaling pathways in prostate cancer
Therapeutic targeting of the androgen signaling pathway is a mainstay treatment for prostate cancer. Although initially effective, resistance to androgen targeted therapies develops followed by disease progres... (Source: BMC Cancer)
Source: BMC Cancer - May 25, 2020 Category: Cancer & Oncology Authors: Maxine G. B. Tran, Becky A. S. Bibby, Lingjian Yang, Franklin Lo, Anne Y. Warren, Deepa Shukla, Michelle Osborne, James Hadfield, Thomas Carroll, Rory Stark, Helen Scott, Antonio Ramos-Montoya, Charlie Massie, Patrick Maxwell, Catharine M. L. West, Ian G. Tags: Research article Source Type: research

Pyruvate anaplerosis is a mechanism of resistance to pharmacological glutaminase inhibition in triple-receptor negative breast cancer
Glutamine serves as an important nutrient with many cancer types displaying glutamine dependence. Following cellular uptake glutamine is converted to glutamate in a reaction catalysed by mitochondrial glutamin... (Source: BMC Cancer)
Source: BMC Cancer - May 25, 2020 Category: Cancer & Oncology Authors: Dean C. Singleton, Anne-Lise Dechaume, Pamela M. Murray, William P. Katt, Bruce C. Baguley and Euphemia Y. Leung Tags: Research article Source Type: research

Metastasis-directed therapy in castration-refractory prostate cancer (MEDCARE): a non-randomized phase 2 trial
Patients diagnosed with metastatic castration-refractory prostate cancer (mCRPC) rely on a limited number of therapeutic agents resulting in a median survival of 2 –3 years. A subgroup of those patients with mC... (Source: BMC Cancer)
Source: BMC Cancer - May 24, 2020 Category: Cancer & Oncology Authors: Charlien Berghen, Steven Joniau, Kato Rans, Ga ëtan Devos, Kenneth Poels, Koen Slabbaert, Herlinde Dumez, Maarten Albersen, Karolien Goffin, Karin Haustermans and Gert De Meerleer Tags: Study protocol Source Type: research

Text mining in a literature review of urothelial cancer using topic model
Urothelial cancer (UC) includes carcinomas of the bladder, ureters, and renal pelvis. New treatments and biomarkers of UC emerged in this decade. To identify the key information in a vast amount of literature ... (Source: BMC Cancer)
Source: BMC Cancer - May 24, 2020 Category: Cancer & Oncology Authors: Hsuan-Jen Lin, Phillip C.-Y. Sheu, Jeffrey J. P. Tsai, Charles C. N. Wang and Che-Yi Chou Tags: Research article Source Type: research

Comparison of 99mTc-MIBI scintigraphy, ultrasound, and mammography for the diagnosis of BI-RADS 4 category lesions
We sought to determine the diagnostic efficacy of Breast-specific gamma imaging (BSGI) in Chinese women with BI-RADS 4 category lesions and to compare this efficacy to that of ultrasound/mammography. (Source: BMC Cancer)
Source: BMC Cancer - May 24, 2020 Category: Cancer & Oncology Authors: Hongbiao Liu, Hongwei Zhan and Da Sun Tags: Research article Source Type: research

Association of Helicobacter pylori babA2 gene and gastric cancer risk: a meta-analysis
The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relations... (Source: BMC Cancer)
Source: BMC Cancer - May 24, 2020 Category: Cancer & Oncology Authors: Marce-Amara Kpoghomou, Jinchen Wang, Tianpei Wang and Guanfu Jin Tags: Research article Source Type: research

Achieving objective response in treatment of non-resectable neuroendocrine tumors does not predict longer time to progression compared to achieving stable disease
There are several treatment modalities for unresectable neuroendocrine tumors. Traditionally, the aim of these treatments has been to reduce the tumor load; referred to as objective response (OR). Less emphasi... (Source: BMC Cancer)
Source: BMC Cancer - May 24, 2020 Category: Cancer & Oncology Authors: Espen Thiis-Evensen, Amalie Christine Poole, Hong-Thien Thi Nguyen and Jon Sponheim Tags: Research article Source Type: research

Insight into bladder cancer care: study protocol of a large nationwide prospective cohort study (BlaZIB)
Despite the embedding of bladder cancer management in European guidelines, large variation in clinical practice exists for applied diagnostics and treatments. This variation may affect patients ’ outcomes inclu... (Source: BMC Cancer)
Source: BMC Cancer - May 20, 2020 Category: Cancer & Oncology Authors: T. M. Ripping, L. A. Kiemeney, L. M. C. van Hoogstraten, J. A. Witjes and K. K. H. Aben Tags: Study protocol Source Type: research

Modified FOLFIRINOX as a second-line therapy following gemcitabine plus nab-paclitaxel therapy in metastatic pancreatic cancer
There is no established second-line treatment after failure of gemcitabine plus nab-paclitaxel (GnP) therapy for metastatic pancreatic cancer (MPC). The purpose of this study was to evaluate the efficacy and t... (Source: BMC Cancer)
Source: BMC Cancer - May 20, 2020 Category: Cancer & Oncology Authors: Masashi Sawada, Akiyoshi Kasuga, Takafumi Mie, Takaaki Furukawa, Takanobu Taniguchi, Koshiro Fukuda, Yuto Yamada, Tsuyoshi Takeda, Ryo Kanata, Masato Matsuyama, Takashi Sasaki, Masato Ozaka and Naoki Sasahira Tags: Research article Source Type: research

The clinical significance of the T2-FLAIR mismatch sign in grade II and III gliomas: a population-based study
The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent... (Source: BMC Cancer)
Source: BMC Cancer - May 20, 2020 Category: Cancer & Oncology Authors: Alba Corell, Sandra Ferreyra Vega, Nickoleta Hoefling, Louise Carstam, Anja Smits, Thomas Olsson Bontell, Isabella M. Bj örkman-Burtscher, Helena Carén and Asgeir Store Jakola Tags: Research article Source Type: research

Association of surgical margins with local recurrence in patients undergoing breast-conserving surgery after neoadjuvant chemotherapy
The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margi... (Source: BMC Cancer)
Source: BMC Cancer - May 20, 2020 Category: Cancer & Oncology Authors: Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang, Ling-Hui Huang, Sam Li-Sheng Chen and Dar-Ren Chen Tags: Research article Source Type: research

Incidence of subsequent primary cancers and radiation-induced subsequent primary cancers after low dose-rate brachytherapy monotherapy for prostate cancer in long-term follow-up
As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an ad... (Source: BMC Cancer)
Source: BMC Cancer - May 20, 2020 Category: Cancer & Oncology Authors: Kristiina Vuolukka, P äivi Auvinen, Jan-Erik Palmgren, Sirpa Aaltomaa and Vesa Kataja Tags: Research article Source Type: research

Tumor-associated tissue eosinophilia predicts favorable clinical outcome in solid tumors: a meta-analysis
Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TAT... (Source: BMC Cancer)
Source: BMC Cancer - May 20, 2020 Category: Cancer & Oncology Authors: Guoming Hu, Shimin Wang, Kefang Zhong, Feng Xu, Liming Huang, Wei Chen and Pu Cheng Tags: Research article Source Type: research

Preoperative SCC-Ag as a predictive marker for the use of adjuvant chemotherapy in cervical squamous cell carcinoma with intermediate-risk factors
For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them. However, who should be adminis... (Source: BMC Cancer)
Source: BMC Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Hong-tao Guo, Xue-han Bi, Ting Lei, Xiao Lv, Guang Yao, Yao Chen and Chang Liu Tags: Research article Source Type: research

The role of human papillomavirus genotyping for detecting high-grade intraepithelial neoplasia or cancer in HPV-positive women with normal cytology: a study from a hospital in northeastern China
This study aimed to analyze the prevalence of high-risk HPV genotypes and evaluate the role ... (Source: BMC Cancer)
Source: BMC Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Jing Zhang, Deyu Zhang, Zhuo Yang, Xiaobin Wang and Danbo Wang Tags: Research article Source Type: research

Multiple HPV 16 infection with two strains: a possible marker of neoplastic progression
We studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution ... (Source: BMC Cancer)
Source: BMC Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Maria Teresa Bruno, Guido Scalia, Nazario Cassaro and Sara Boemi Tags: Research article Source Type: research

Comparison of hybrid clones derived from human breast epithelial cells and three different cancer cell lines regarding in vitro cancer stem/ initiating cell properties
Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion. In cancer it was postulated that the fusion... (Source: BMC Cancer)
Source: BMC Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Sera Selina Fahlbusch, Silvia Keil, J örg T. Epplen, Kurt S. Zänker and Thomas Dittmar Tags: Research article Source Type: research

Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis
Circular RNAs (circRNAs) are research hotspots in the network of noncoding RNAs in numerous tumours. The purpose of our study was to evaluate the clinicopathological, prognostic and diagnostic value of circRNA... (Source: BMC Cancer)
Source: BMC Cancer - May 19, 2020 Category: Cancer & Oncology Authors: Jinpeng Yuan, Dongming Guo, Xinxin Li and Juntian Chen Tags: Research article Source Type: research

Quantitative hormone receptor (HR) expression and gene expression analysis in HR+ inflammatory breast cancer (IBC) vs non-IBC
The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior. (Source: BMC Cancer)
Source: BMC Cancer - May 18, 2020 Category: Cancer & Oncology Authors: Toshiaki Iwase, Kenichi Harano, Hiroko Masuda, Kumiko Kida, Kenneth R. Hess, Ying Wang, Luc Dirix, Steven J. Van Laere, Anthony Lucci, Savitri Krishnamurthy, Wendy A. Woodward, Rachel M. Layman, Fran çois Bertucci and Naoto T. Ueno Tags: Research article Source Type: research

The association of depressive symptoms, personality traits, and sociodemographic factors with health-related quality of life and quality of life in patients with advanced-stage lung cancer: an observational multi-center cohort study
Identification of patient-related factors associated with Health-Related Quality of Life (HRQoL) and Quality of Life (QoL) at the start of treatment may identify patients who are prone to a decrease in HRQoL a... (Source: BMC Cancer)
Source: BMC Cancer - May 18, 2020 Category: Cancer & Oncology Authors: Mark de Mol, Sabine Visser, Joachim Aerts, Paul Lodder, Nico van Walree, Huub Belderbos and Brenda den Oudsten Tags: Research article Source Type: research

The combination of methotrexate and cytosine arabinoside in newly diagnosed adult Langerhans cell histiocytosis: a prospective phase II interventional clinical trial
Langerhans Cell Histiocytosis (LCH) is a rare disease puzzling both children and adults, however outcome of adult patients is unfavorable. This prospective interventional trial aims to test the efficacy and sa... (Source: BMC Cancer)
Source: BMC Cancer - May 18, 2020 Category: Cancer & Oncology Authors: Xiao Han, Mingqi Ouyang, Minghui Duan, Wei Zhang, Tienan Zhu, Jian Li, Shujie Wang and Daobin Zhou Tags: Research article Source Type: research

Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells
Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various e... (Source: BMC Cancer)
Source: BMC Cancer - May 18, 2020 Category: Cancer & Oncology Authors: Paulina Gil-Kulik, Ewa Dudzi ńska, Elżbieta Radzikowska-Büchner, Joanna Wawer, Mariusz Jojczuk, Adam Nogalski, Genowefa Anna Wawer, Marcin Feldo, Wojciech Kocki, Maria Cioch, Anna Bogucka-Kocka, Mansur Rahnama and Janusz Kocki Tags: Research article Source Type: research

DPD status and fluoropyrimidines-based treatment: high activity matters too
Dihydropyrimidine dehydrogenase (DPD) status is an indicator of a marked risk for toxicity following fluoropyrimidine (FP)-based chemotherapy. This notion is well-established for low DPD status but little is k... (Source: BMC Cancer)
Source: BMC Cancer - May 18, 2020 Category: Cancer & Oncology Authors: Emmanuel Chamorey, Eric Francois, Marie-Christine Etienne, Jean-Marc Ferrero, Frederic Peyrade, Emmanuel Barranger, Alexandre Bozec, R émy Largillier, Ophelie Cassuto, Julien Viotti, Renaud Schiappa and Gérard Milano Tags: Research article Source Type: research

A competing risk nomogram predicting cause-specific mortality in patients with lung adenosquamous carcinoma
Adenosquamous carcinoma (ASC) is an uncommon histological subtype of lung cancer. The purpose of this study was to assess the cumulative incidences of lung cancer-specific mortality (LC-SM) and other cause-spe... (Source: BMC Cancer)
Source: BMC Cancer - May 16, 2020 Category: Cancer & Oncology Authors: Xiao Wu, Wenfeng Yu, R. H. Petersen, Hongxu Sheng, Yiqing Wang, Wang Lv and Jian Hu Tags: Research article Source Type: research

Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells
α-tocopherol (AT) and γ-tocotrienol (GT3) are vitamin E isoforms considered to have potential chemopreventive properties. AT has been widely studied in vitro and in clinical trials with mixed results. The late... (Source: BMC Cancer)
Source: BMC Cancer - May 15, 2020 Category: Cancer & Oncology Authors: Christine Moore, Victoria E. Palau, Rashid Mahboob, Janet Lightner, William Stone and Koyamangalath Krishnan Tags: Research article Source Type: research

Targeted imaging of orthotopic prostate cancer by using clinical transformable photoacoustic molecular probe
To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as t... (Source: BMC Cancer)
Source: BMC Cancer - May 14, 2020 Category: Cancer & Oncology Authors: Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng and Rongqin Zheng Tags: Research article Source Type: research

Prognostic implication and functional exploration for microRNA-20a as a molecular biomarker of gastrointestinal cancer
It is generally accepted that microRNA-20a (miR-20a) is aberrantly expressed in gastrointestinal cancer (GIC), and may be associated with the prognosis of GIC patients. Nevertheless, the clinical prognostic va... (Source: BMC Cancer)
Source: BMC Cancer - May 14, 2020 Category: Cancer & Oncology Authors: Qiliang Peng, Peifeng Zhao, Yi Shen, Ming Cheng, Yongyou Wu and Yaqun Zhu Tags: Research article Source Type: research

Disease-free survival as a surrogate endpoint for overall survival in adjuvant trials of pancreatic cancer: a meta-analysis of 20 randomized controlled trials
We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS) in adjuvant trials of pancreatic cancer. (Source: BMC Cancer)
Source: BMC Cancer - May 14, 2020 Category: Cancer & Oncology Authors: Run-Cong Nie, Xue-Bin Zou, Shu-Qiang Yuan, Ying-Bo Chen, Shi Chen, Yong-Ming Chen, Guo-Ming Chen, Xiao-Jiang Chen, Tian-Qi Luo, Shu-Man Li, Jin-Ling Duan, Yun Wang and Yuan-Fang Li Tags: Research article Source Type: research

Podoplanin is a useful prognostic marker and indicates better differentiation in lung squamous cell cancer patients? A systematic review and meta-analysis
The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis among squamo... (Source: BMC Cancer)
Source: BMC Cancer - May 14, 2020 Category: Cancer & Oncology Authors: Liya Hu, Peng Zhang, Qi Mei, Wei Sun, Lei Zhou and Tiejun Yin Tags: Research article Source Type: research

PPFIA1 expression associates with poor response to endocrine treatment in luminal breast cancer
PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate th... (Source: BMC Cancer)
Source: BMC Cancer - May 14, 2020 Category: Cancer & Oncology Authors: Lutfi H. Alfarsi, Rokaya El Ansari, Madeleine L. Craze, Brendah K. Masisi, Ian O. Ellis, Emad A. Rakha and Andrew R. Green Tags: Research article Source Type: research

Gene networks and expression quantitative trait loci associated with adjuvant chemotherapy response in high-grade serous ovarian cancer
A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underly... (Source: BMC Cancer)
Source: BMC Cancer - May 13, 2020 Category: Cancer & Oncology Authors: Jihoon Choi, Danai G. Topouza, Anastasiya Tarnouskaya, Sean Nesdoly, Madhuri Koti and Qing Ling Duan Tags: Research article Source Type: research

Rehabilitation strategies following oesophagogastric and Hepatopancreaticobiliary cancer (ReStOre II): a protocol for a randomized controlled trial
Curative treatment for upper gastrointestinal (UGI) and hepatopancreaticobiliary (HPB) cancers, involves complex surgical resection often in combination with neoadjuvant/adjuvant chemo/chemoradiotherapy. With ... (Source: BMC Cancer)
Source: BMC Cancer - May 13, 2020 Category: Cancer & Oncology Authors: Linda O ’Neill, Emer Guinan, Suzanne Doyle, Deirdre Connolly, Jacintha O’Sullivan, Annemarie Bennett, Grainne Sheill, Ricardo Segurado, Peter Knapp, Ciaran Fairman, Charles Normand, Justin Geoghegan, Kevin Conlon, John V. Reynolds and Juliette Hussey Tags: Study protocol Source Type: research

Dynamic alterations of genome and transcriptome in KRAS G13D mutant CRC PDX model treated with cetuximab
KRAS mutations have been characterized as the major predictive biomarkers for resistance to cetuximab treatment. However, studies indicate that not all KRAS mutations are associated with equivalent treatment o... (Source: BMC Cancer)
Source: BMC Cancer - May 13, 2020 Category: Cancer & Oncology Authors: Hangyu Zhang, Liyun Yuan, Lulu Liu, Cong Yan, Jinming Cheng, Qihan Fu, Zhou Tong, Weiqin Jiang, Yi Zheng, Peng Zhao, Guoqing Zhang and Weijia Fang Tags: Research article Source Type: research

Novel methods for in vitro modeling of pancreatic cancer reveal important aspects for successful primary cell culture
Pancreatic cancer remains a fatal disease. Experimental systems are needed for personalized treatment strategies, drug testing and to further understand tumor biology. Cell cultures can serve as an excellent p... (Source: BMC Cancer)
Source: BMC Cancer - May 13, 2020 Category: Cancer & Oncology Authors: L. Ehlen, J. Arndt, D. Treue, P. Bischoff, F. N. Loch, E. M. Hahn, K. Kotsch, F. Klauschen, K. Beyer, G. A. Margonis, M. E. Kreis and C. Kamphues Tags: Research article Source Type: research