Small RNA expression from viruses, bacteria and human miRNAs in colon cancer tissue and its association with microsatellite instability and tumor location
MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in cancer and are promising biomarkers for colon cancer. Here we profile human, virus and bacteria small RNAs in normal and tumor tissue from ... (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2019 Category: Cancer & Oncology Authors: Robin Mjelle, Wenche Sjursen, Liv Thommesen, P ål Sætrom and Eva Hofsli Tags: Research article Source Type: research

Metastasis in penile corpus cavernosum from esophageal squamous carcinoma after curative resection: a case report
Metastasis in penile corpus cavernosum from esophageal squamous carcinoma is a rare but fatal disease, which was reported in cases without series studies. (Source: BMC Cancer)
Source: BMC Cancer - February 20, 2019 Category: Cancer & Oncology Authors: Lingmin Song, Yangmin Wang and Guobin Weng Tags: Case report Source Type: research

Accuracy of the Delirium Observational Screening Scale (DOS) as a screening tool for delirium in patients with advanced cancer
The Delirium Observation Screening Scale (DOS) was developed to facilitate early recognition of delirium by nurses during routine clinical care. It has shown good validity in a variety of patient populations, ... (Source: BMC Cancer)
Source: BMC Cancer - February 19, 2019 Category: Cancer & Oncology Authors: Elisabeth C. W. Neefjes, Maurice J. D. L. van der Vorst, Manon S. A. Boddaert, Bea A. T. T. Verdegaal, Aart Beeker, Saskia C. C. Teunissen, Aartjan T. F. Beekman, Wouter W. A. Zuurmond, Johannes Berkhof and Henk M. W. Verheul Tags: Research article Source Type: research

Expression and activity of the calcitonin receptor family in a sample of primary human high-grade gliomas
Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15  months, identification and validation of new GBM therapeutic targets is of critical impor... (Source: BMC Cancer)
Source: BMC Cancer - February 18, 2019 Category: Cancer & Oncology Authors: Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton and Sebastian G. B. Furness Tags: Research article Source Type: research

Autocrine production of reproductive axis neuropeptides affects proliferation of canine osteosarcoma in vitro
Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utiliz... (Source: BMC Cancer)
Source: BMC Cancer - February 18, 2019 Category: Cancer & Oncology Authors: Marcus A. Weinman, Jacob A. Fischer, Dakota C. Jacobs, Cheri P. Goodall, Shay Bracha and Patrick E. Chappell Tags: Research article Source Type: research

Stromal cell ratio based on automated image analysis as a predictor for platinum-resistant recurrent ovarian cancer
Identifying high-risk patients for platinum resistance is critical for improving clinical management of ovarian cancer. We aimed to use automated image analysis of hematoxylin& eosin (H&E) stained sections to... (Source: BMC Cancer)
Source: BMC Cancer - February 18, 2019 Category: Cancer & Oncology Authors: C. Lan, J. Li, X. Huang, A. Heindl, Y. Wang, S. Yan and Y. Yuan Tags: Research article Source Type: research

The efficacy and toxicity of cabazitaxel for treatment of docetaxel-resistant prostate cancer correlating with the initial doses in Japanese patients
We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC). (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2019 Category: Cancer & Oncology Authors: Naoki Terada, Toshiyuki Kamoto, Hiromasa Tsukino, Shoichiro Mukai, Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa, Shintaro Narita, Tomonori Habuchi, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai, Shuya Kandori, Takahiro Kojima, Hiroyuki Nishiyama, Yoshi Tags: Research article Source Type: research

Correction to: Cervical and breast cancer screening uptake among women with serious mental illness: a data linkage study
Following publication of the original article [1], the authors notified us of an error in the reported percentages in Table 3. (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2019 Category: Cancer & Oncology Authors: Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart and Max J. Henderson Tags: Correction Source Type: research

Reproductive cancer risk factors among relatives of cancer patients in a tertiary oncology center
The aim of this study was to evaluate the prevalence of some gynecological cancer risk factors in a population of female relatives of cancer patients in Hacettepe University Oncology Hospital. Additionally, wh... (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2019 Category: Cancer & Oncology Authors: Nooria Atta, Saadettin Kilickap, Deniz Yuce and Mutlu Hayran Tags: Research article Source Type: research

Insluin and epithelial growth factor (EGF) promote programmed death ligand 1(PD-L1) production and transport in colon cancer stem cells
Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells).... (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2019 Category: Cancer & Oncology Authors: Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro and Wenyi Gu Tags: Research article Source Type: research

Prognostic impact of mRNA levels of LGR5 transcript variants in OSCC patients
The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, brea... (Source: BMC Cancer)
Source: BMC Cancer - February 15, 2019 Category: Cancer & Oncology Authors: Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje G üttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert and Matth Tags: Research article Source Type: research

Risk and consequences of chemotherapy-induced thrombocytopenia in US clinical practice
Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, dose reductions, or discontinuation, and increases the risk of serious bleeding even... (Source: BMC Cancer)
Source: BMC Cancer - February 14, 2019 Category: Cancer & Oncology Authors: Derek Weycker, Mark Hatfield, Aaron Grossman, Ahuva Hanau, Alex Lonshteyn, Anjali Sharma and David Chandler Tags: Research article Source Type: research

Immediate-term cognitive impairment following intravenous (IV) chemotherapy: a prospective pre-post design study
This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to a... (Source: BMC Cancer)
Source: BMC Cancer - February 14, 2019 Category: Cancer & Oncology Authors: Omar F. Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J. Ko, Haocheng Li, Aalok Kumar, Michael M. Vickers and Patricia A. Tang Tags: Research article Source Type: research

Patient satisfaction of radiofrequency ablation for symptomatic benign solid thyroid nodules: our experience for 2-year follow up
The patient satisfaction of symptoms improvement and disease factors that may affect long-term treatment efficacy of radiofrequency ablation (RFA) for non-functioning solid benign thyroid nodules (TNs) over a ... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2019 Category: Cancer & Oncology Authors: Yang Guang, Wen He, Yukun Luo, Hongxia Zhang, Yukang Zhang, Bin Ning and Tengfei Yu Tags: Research article Source Type: research

Long-term survival and prognostic factors for locally advanced renal cell carcinoma with renal vein tumor thrombus
Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few ... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2019 Category: Cancer & Oncology Authors: Chuanzhen Cao, Xingang Bi, Jing Liang, Lin Li, Huijuan Zhang, Zhendong Xiao, Zejun Xiao, Jun Tian, Dong Wang, Kaopeng Guan, Changling Li, Jianhui Ma, Shan Zheng and Jianzhong Shou Tags: Research article Source Type: research

Sleep disorders associated with risk of prostate cancer: a population-based cohort study
Disrupted sleep rhythms may lead to cancer development. We conducted a population-based cohort study to evaluate the incidence and risk of prostate cancer in patients with sleep disorders (SDs). (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2019 Category: Cancer & Oncology Authors: Wei-Sheng Chung and Cheng-Li Lin Tags: Research article Source Type: research

Genetic analysis of a novel antioxidant multi-target iron chelator, M30 protecting against chemotherapy-induced alopecia in mice
Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in ... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2019 Category: Cancer & Oncology Authors: Young-Cheol Lim, Hyeongi Kim, Sang Moo Lim and Jin Su Kim Tags: Research article Source Type: research

Hypoxia-induced cancer stemness acquisition is associated with CXCR4 activation by its aberrant promoter demethylation
A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. H... (Source: BMC Cancer)
Source: BMC Cancer - February 13, 2019 Category: Cancer & Oncology Authors: Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim and Seung Joon Kim Tags: Research article Source Type: research

Hematologic markers of distant metastases and poor prognosis in gynecological cancers
Despite the recent progress in the development of anti-cancer drugs, the treatment of metastatic tumors is usually ineffective. The systemic inflammatory response performs key roles in different stages of the ... (Source: BMC Cancer)
Source: BMC Cancer - February 12, 2019 Category: Cancer & Oncology Authors: O. Abu-Shawer, M. Abu-Shawer, N. Hirmas, A. Alhouri, A. Massad, B. Alsibai, H. Sultan, H. Hammo, M. Souleiman, Y. Shebli and M. Al-Hussaini Tags: Research article Source Type: research

Different next-generation sequencing pipelines based detection of tumor DNA in cerebrospinal fluid of lung adenocarcinoma cancer patients with leptomeningeal metastases
The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different ... (Source: BMC Cancer)
Source: BMC Cancer - February 12, 2019 Category: Cancer & Oncology Authors: Mengxi Ge, Qiong Zhan, Zhenzhen Zhang, Xiaoyu Ji, Xinli Zhou, Ruofan Huang and Xiaohua Liang Tags: Research article Source Type: research

Programmed Death Ligand-1 expression in stage II colon cancer - experiences from a nationwide populationbased cohort
Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the progno... (Source: BMC Cancer)
Source: BMC Cancer - February 12, 2019 Category: Cancer & Oncology Authors: Ann C. Eriksen, Flemming B. S ørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt and Torben F. Hansen Tags: Research article Source Type: research

Prognostic value of adipose tissue and muscle mass in advanced colorectal cancer: a post hoc analysis of two non-randomized phase II trials
The prognostic value of body composition in cancer patients has been widely studied during the last decade. The main finding of these studies is that sarcopenia, or skeletal muscle depletion, assessed by CT im... (Source: BMC Cancer)
Source: BMC Cancer - February 12, 2019 Category: Cancer & Oncology Authors: Nicolas Charette, Caroline Vandeputte, Lieveke Ameye, Camille Van Bogaert, Jonathan Krygier, Thomas Guiot, Am élie Deleporte, Thierry Delaunoit, Karen Geboes, Jean-Luc Van Laethem, Marc Peeters, Gauthier Demolin, Stéphane Holbrechts, Patrick Flamen, Mar Tags: Research article Source Type: research

Trefoil factors peptide-3 is associated with residual invasive breast carcinoma following neoadjuvant chemotherapy
Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5 ′ promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen a... (Source: BMC Cancer)
Source: BMC Cancer - February 11, 2019 Category: Cancer & Oncology Authors: Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad and Mohamed Al Bashir Tags: Research article Source Type: research

Role of polycyclic aromatic hydrocarbons as a co-factor in human papillomavirus-mediated carcinogenesis
Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one o... (Source: BMC Cancer)
Source: BMC Cancer - February 11, 2019 Category: Cancer & Oncology Authors: Chuqing Zhang, Yunjing Luo, Rugang Zhong, Priscilla T. Y. Law, Siaw Shi Boon, Zigui Chen, Chi-Hang Wong and Paul K. S. Chan Tags: Research article Source Type: research

Cost-effectiveness of bevacizumab plus paclitaxel versus paclitaxel for the first-line treatment of HER2-negative metastatic breast cancer in specialist oncology centers in France
Evidence from clinical trials suggests that the addition of bevacizumab to chemotherapy in the first-line treatment of patients with HER2-negative metastatic breast cancer improves progression-free survival (P... (Source: BMC Cancer)
Source: BMC Cancer - February 11, 2019 Category: Cancer & Oncology Authors: Audrey Petitjean, Jayne Smith-Palmer, William Valentine, Bertrand Tehard and Stephan é Roze Tags: Research article Source Type: research

Cancer-associated fibroblasts induce epithelial –mesenchymal transition of bladder cancer cells through paracrine IL-6 signalling
Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer pro... (Source: BMC Cancer)
Source: BMC Cancer - February 11, 2019 Category: Cancer & Oncology Authors: Cassandra Ringuette Goulet, Audrey Champagne, Genevi ève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot and Stéphane Bolduc Tags: Research article Source Type: research

A genome-wide association study identifies single nucleotide polymorphisms associated with time-to-metastasis in colorectal cancer
Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability... (Source: BMC Cancer)
Source: BMC Cancer - February 9, 2019 Category: Cancer & Oncology Authors: Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas and Yildiz E. Yilmaz Tags: Research article Source Type: research

Positive response to Icotinib in metastatic lung adenocarcinoma with acquiring EGFR Leu792H mutation after AZD9291 treatment: a case report
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been emerged as the standard selection in non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutations. However, primar... (Source: BMC Cancer)
Source: BMC Cancer - February 8, 2019 Category: Cancer & Oncology Authors: Junhui Wang and Jianxin Chen Tags: Case report Source Type: research

Breaking silence: a survey of barriers to goals of care discussions from the perspective of oncology practitioners
Cancer is the leading cause of death in the developed world, and yet healthcare practitioners infrequently discuss goals of care (GoC) with hospitalized cancer patients. We sought to identify barriers to GoC d... (Source: BMC Cancer)
Source: BMC Cancer - February 8, 2019 Category: Cancer & Oncology Authors: Katrina Lynn Piggott, Ameen Patel, Arthur Wong, Leslie Martin, Alexandra Patel, Matthew Patel, Yudong Liu, Sukhbinder Dhesy-Thind and John J. You Tags: Research article Source Type: research

Are we mis-estimating chemotherapy-induced peripheral neuropathy? Analysis of assessment methodologies from a prospective, multinational, longitudinal cohort study of patients receiving neurotoxic chemotherapy
This study explored CIPN natural history and its characteristics in pat... (Source: BMC Cancer)
Source: BMC Cancer - February 8, 2019 Category: Cancer & Oncology Authors: Alex Molassiotis, Hui Lin Cheng, Violeta Lopez, Joseph S. K. Au, Alexandre Chan, Aishwarya Bandla, K. T. Leung, Y. C. Li, K. H. Wong, Lorna K. P. Suen, Choi Wan Chan, Janelle Yorke, Carole Farrell and Raghav Sundar Tags: Research article Source Type: research

Identification of non-invasive biomarkers for chronic atrophic gastritis from serum exosomal microRNAs
Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating biomarkers for Chronic atrophic gastritis (CAG) which is defined ... (Source: BMC Cancer)
Source: BMC Cancer - February 8, 2019 Category: Cancer & Oncology Authors: Hong Liu, Pei-wu Li, Wei-qin Yang, Hong Mi, Jing-lin Pan, Yuan-cheng Huang, Zheng-kun Hou, Qiu-ke Hou, Qi Luo and Feng-bin Liu Tags: Research article Source Type: research

Correction to: Risk of biochemical recurrence based on extent and location of positive surgical margins after robot-assisted laparoscopic radical prostatectomy
Following publication of the original article [1], we have been notified that the authors ’ last names have been incorrectly tagged as first names and vice-versa. The original publication has been corrected. (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2019 Category: Cancer & Oncology Authors: Gautier Marcq, Aude Michelet, Gerjon Hannink, Jerome Rizk, Jean Sauvain, Arnauld Villers, Mo Saffarini and Charles-Henry Rochat Tags: Correction Source Type: research

Immune targeting of autocrine IGF2 hampers rhabdomyosarcoma growth and metastasis
Insulin-like Growth Factor Receptor-1 (IGF1R) system sustains the genesis of rhabdomyosarcoma through IGF2 autocrine overexpression. While several IGF1R-targeted strategies have been investigated to interphere... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2019 Category: Cancer & Oncology Authors: Carla De Giovanni, Patrizia Nanni, Lorena Landuzzi, Marianna L. Ianzano, Giordano Nicoletti, Stefania Croci, Arianna Palladini and Pier-Luigi Lollini Tags: Research article Source Type: research

Damage to sebaceous gland and the efficacy of moisturizer after whole breast radiotherapy: a randomized controlled trial
We report the time-course of sebum content after whole breast radiotherapy (WBRT) and the efficac... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2019 Category: Cancer & Oncology Authors: Mami Ogita, Kenji Sekiguchi, Keiko Akahane, Ryoko Ito, Chiori Haga, Satoru Arai, Yasushi Ishida and Jiro Kawamori Tags: Research article Source Type: research

Tumor classification and biomarker discovery based on the 5 ’isomiR expression level
The miRNA isoforms (isomiRs) have been suggested to regulate the same pathways as the canonical miRNA and play an important biological role in miRNA-mediated gene regulation. Recently, a study has demonstrated... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2019 Category: Cancer & Oncology Authors: Shengqin Wang, Zhihong Zheng, Peichao Chen and Mingjiang Wu Tags: Research article Source Type: research

Risk prediction for breast Cancer in Han Chinese women based on a cause-specific Hazard model
Considering the lack of efficient breast cancer prediction models suitable for general population screening in China. We aimed to develop a risk prediction model to identify high-risk populations, to help with... (Source: BMC Cancer)
Source: BMC Cancer - February 7, 2019 Category: Cancer & Oncology Authors: Lu Wang, Liyuan Liu, Zhen Lou, Lijie Ding, Hui Guan, Fei Wang, Lixiang Yu, Yujuan Xiang, Fei Zhou, Fuzhong Xue and Zhigang Yu Tags: Research article Source Type: research

Efficacy and safety of RGB-02, a pegfilgrastim biosimilar to prevent chemotherapy-induced neutropenia: results of a randomized, double-blind phase III clinical study vs. reference pegfilgrastim in patients with breast cancer receiving chemotherapy
Treatment with recombinant human granulocyte-colony stimulating factor (G-CSF) is accepted standard for prevention of chemotherapy-induced neutropenia. RGB-02 (Gedeon Richter) is a proposed biosimilar to pegyl... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2019 Category: Cancer & Oncology Authors: Zsuzsanna Kahan, Daniela Grecea, Martin Smakal, Sergei Tjulandin, Igor Bondarenko, Luca Perjesi, Andras Illes, Karoly Horvat-Karajz and Ildiko Aradi Tags: Research article Source Type: research

Increased expression of Ki-67 is a poor prognostic marker for colorectal cancer patients: a meta analysis
The prognostic value of Ki-67 expression in colorectal cancer patients was controversial. Therefore, this meta analysis was conducted to ascertain the prognostic value of Ki-67 expression in colorectal cancer ... (Source: BMC Cancer)
Source: BMC Cancer - February 6, 2019 Category: Cancer & Oncology Authors: Zhao-Wen Luo, Ming-Gu Zhu, Zhi-Qiao Zhang, Feng-Jun Ye, Wen-Heng Huang and Xue-Zhang Luo Tags: Research article Source Type: research

Dissimilar patterns of tumor-infiltrating immune cells at the invasive tumor front and tumor center are associated with response to neoadjuvant chemotherapy in primary breast cancer
Tumor-infiltrating lymphocytes (TILs) are described as an important immune modulator in the tumor microenvironment and are associated with breast cancer (BC) outcome. The spatial analysis of TILs and TIL subty... (Source: BMC Cancer)
Source: BMC Cancer - February 4, 2019 Category: Cancer & Oncology Authors: Lisa K önig, Fabian D. Mairinger, Oliver Hoffmann, Ann-Kathrin Bittner, Kurt W. Schmid, Rainer Kimmig, Sabine Kasimir-Bauer and Agnes Bankfalvi Tags: Research article Source Type: research

Impact of in vitro driven expression signatures of CD133 stem cell marker and tumor stroma on clinical outcomes in gastric cancers
The CD133 transmembrane protein is a well-recognized stem cell marker that has been used to isolate putative cancer stem cell populations from gastric cancers (GCs). However, the molecular features or biomarke... (Source: BMC Cancer)
Source: BMC Cancer - February 4, 2019 Category: Cancer & Oncology Authors: Tae-Min Kim, Yoon Ho Ko, Shin Jung Ha and Han Hong Lee Tags: Research article Source Type: research

Study protocol: a multi-centre randomised study of induction chemotherapy followed by capecitabine ± nelfinavir with high- or standard-dose radiotherapy for locally advanced pancreatic cancer (SCALOP-2)
Induction chemotherapy followed by chemoradiation is a treatment option for patients with locally advanced pancreatic cancer (LAPC). However, overall survival is comparable to chemotherapy alone and local prog... (Source: BMC Cancer)
Source: BMC Cancer - February 4, 2019 Category: Cancer & Oncology Authors: Victoria Y. Strauss, Rachel Shaw, Pradeep S. Virdee, Christopher N. Hurt, Elizabeth Ward, Bethan Tranter, Neel Patel, John Bridgewater, Philip Parsons, Ganesh Radhakrishna, Eric O ’Neill, David Sebag-Montefiore, Maria Hawkins, Pippa G. Corrie, Timothy M Tags: Study protocol Source Type: research

Intraosseous synovial sarcoma of the distal ulna: a case report and review of the literature
Synovial sarcoma is a relatively rare type of soft tissue sarcoma. The commonly observed symptom is a deep-seated palpable mass accompanied by pain or tenderness. Thus, it is considered a soft tissue sarcoma a... (Source: BMC Cancer)
Source: BMC Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Taketsugu Fujibuchi, Joji Miyawaki, Teruki Kidani, Hiroshi Imai, Hiroshi Kiyomatsu, Riko Kitazawa and Hiromasa Miura Tags: Case report Source Type: research

Crosslink between Temozolomide and PD-L1 immune-checkpoint inhibition in glioblastoma multiforme
In recent years, PD-1/PD-L1 immune checkpoint inhibitors have improved cancer therapy in many tumor types, but no benefit of immune checkpoint therapy has been found in glioblastoma multiforme (GBM). Based on ... (Source: BMC Cancer)
Source: BMC Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Sabrina Heynckes, Karam Daka, Pamela Franco, Annette Gaebelein, Jan Hendrik Frenking, Roberto Doria-Medina, Irina Mader, Daniel Delev, Oliver Schnell and Dieter Henrik Heiland Tags: Research article Source Type: research

Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients
Significant numbers of variants detected in cancer patients are often left labeled only as variants of unknown significance (VUS). In order to expand precision medicine to a wider population, we need to extend... (Source: BMC Cancer)
Source: BMC Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Takahiko Koyama, Kahn Rhrissorrakrai and Laxmi Parida Tags: Research article Source Type: research

Prevalence of germline mutations in the TP53 gene in patients with early-onset breast cancer in the Mexican population
Heterozygous germline TP53 gene mutations result in Li-Fraumeni Syndrome (LFS). Breast cancer (BC) is the most frequent tumor in young women with LFS. An important issue related to BC in the Mexican population is... (Source: BMC Cancer)
Source: BMC Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Lenny N. Gallardo-Alvarado, Mar ía Teresa Tusié-Luna, María Isabel Tussié-Luna, José Díaz-Chávez, Yayoi X. Segura, Enrique Bargallo-Rocha, Cynthia Villarreal, Luis A. Herrera-Montalvo, Enrique M. Herrera-Medina and David F. Cantu-de Leon Tags: Research article Source Type: research

Predictors for use of psychosocial services in patients with metastatic colorectal cancer receiving first line systemic treatment
In this study we aimed ... (Source: BMC Cancer)
Source: BMC Cancer - February 1, 2019 Category: Cancer & Oncology Authors: Claudia S. E. W. Schuurhuizen, Annemarie M. J. Braamse, Inge R. H. M. Konings, Henk M. W. Verheul and Joost Dekker Tags: Research article Source Type: research

Opioid response in paediatric cancer patients and the Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene: an Italian study on 87 cancer children and a systematic review
Genetic polymorphisms in genes involved in pain modulation have been reported to be associated to opioid efficacy and safety in different clinical settings. (Source: BMC Cancer)
Source: BMC Cancer - January 31, 2019 Category: Cancer & Oncology Authors: Ersilia Lucenteforte, Alfredo Vannacci, Giada Crescioli, Niccol ò Lombardi, Laura Vagnoli, Laura Giunti, Valentina Cetica, Maria Luisa Coniglio, Alessandra Pugi, Roberto Bonaiuti, Maurizio Aricò, Sabrina Giglio, Andrea Messeri, Roberto Barale, Lisa Giov Tags: Research article Source Type: research

Selection of three miRNA signatures with prognostic value in non-M3 acute myeloid leukemia
MiRNAs that are potential biomarkers for predicting prognosis for acute myeloid leukemia (AML) have been identified. However, comprehensive analyses investigating the association between miRNA expression profi... (Source: BMC Cancer)
Source: BMC Cancer - January 30, 2019 Category: Cancer & Oncology Authors: Yao Xue, Yuqiu Ge, Meiyun Kang, Cong Wu, Yaping Wang, Liucheng Rong and Yongjun Fang Tags: Research article Source Type: research

MiRNA detection in cervical exfoliated cells for missed high-grade lesions in women with LSIL/CIN1 diagnosis after colposcopy-guided biopsy
Low-grade squamous intraepithelial lesion/cervical intraepithelial neoplasia grade 1 (LSIL/CIN1) preceded by colposcopy guided biopsy is recommended conservative follow-up, although some of these lesions are a... (Source: BMC Cancer)
Source: BMC Cancer - January 30, 2019 Category: Cancer & Oncology Authors: Jing Ye, Xiao-dong Cheng, Bei Cheng, Yi-fan Cheng, Xiao-Jing Chen and Wei-guo Lu Tags: Research article Source Type: research

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro
Malignant pleural mesothelioma (MPM) is a tumour arising from pleural cavities with poor prognosis. Multimodality treatment with pemetrexed combined with cisplatin shows unsatisfying response-rates of 40%. The... (Source: BMC Cancer)
Source: BMC Cancer - January 30, 2019 Category: Cancer & Oncology Authors: Sabrina Borchert, Michael Wessolly, Jan Schmeller, Elena Mairinger, Jens Kollmeier, Thomas Hager, Thomas Mairinger, Thomas Herold, Daniel C. Christoph, Robert F. H. Walter, Wilfried E. E. Eberhardt, Till Pl önes, Jeremias Wohlschlaeger, Clemens Aigner, K Tags: Research article Source Type: research