miR-520d-5p can reduce the mutations in hepatoma cancer cells and iPSCs-derivatives
Human microRNAs (miRNAs) have diverse functions in biology, and play a role in nearly every biological process. Here we report that miR-520d-5p (520d-5p) causes undifferentiated cancer cells to adopt benign or... (Source: BMC Cancer)
Source: BMC Cancer - June 15, 2019 Category: Cancer & Oncology Authors: Norimasa Miura, Yoshitaka Ishihara, Yugo Miura, Mai Kimoto and Keigo Miura Tags: Research article Source Type: research

A pan-cancer perspective of matrix metalloproteases (MMP) gene expression profile and their diagnostic/prognostic potential
By understanding Matrix Metalloprotease (MMP) dysregulation from a pan-cancer perspective, this study sheds light on the diagnostic potentials of MMPs across multiple neoplasms. (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2019 Category: Cancer & Oncology Authors: Emily Gobin, Kayla Bagwell, John Wagner, David Mysona, Sharmila Sandirasegarane, Nathan Smith, Shan Bai, Ashok Sharma, Robert Schleifer and Jin-Xiong She Tags: Research article Source Type: research

Investigating the potential clinical benefit of Selumetinib in resensitising advanced iodine refractory differentiated thyroid cancer to radioiodine therapy (SEL-I-METRY): protocol for a multicentre UK single arm phase II trial
Thyroid cancer is the most common endocrine malignancy. Some advanced disease is, or becomes, resistant to radioactive iodine therapy (refractory disease); this holds poor prognosis of 10% 10-year overall surv... (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2019 Category: Cancer & Oncology Authors: Sarah R. Brown, Andrew Hall, Hannah L. Buckley, Louise Flanagan, David Gonzalez de Castro, Kate Farnell, Laura Moss, Rebecca Gregory, Kate Newbold, Yong Du, Glenn Flux and Jonathan Wadsley Tags: Study protocol Source Type: research

Choice of immobilization of stereotactic body radiotherapy in lung tumor patient by BMI
This study compared thermoplastic masks (TMP) and vacuum cushion... (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2019 Category: Cancer & Oncology Authors: Guofu Chen, Baiqiang Dong, Guoping Shan, Xiuqin Zhang, Huarong Tang, Yuchen Li, Zhenhua Wang, Wei Xu, Gang Xu, Guiming Yan, Feiyan Zhang, Xiao Hu, Jun Yang, Yujin Xu, Ming Chen and Jin Wang Tags: Research article Source Type: research

Expression profiles of VEGF-A, VEGF-D and VEGFR1 are higher in distant metastases than in matched primary high grade epithelial ovarian cancer
In many malignancies including ovarian cancer, different angiogenic factors have been related to poor prognosis. However, data on their relations to each other or importance as a prognostic factor in ovarian c... (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2019 Category: Cancer & Oncology Authors: Minna Sopo, Maarit Anttila, Kirsi H ämäläinen, Annukka Kivelä, Seppo Ylä-Herttuala, Veli-Matti Kosma, Leea Keski-Nisula and Hanna Sallinen Tags: Research article Source Type: research

PRAF2 overexpression predicts poor prognosis and promotes tumorigenesis in esophageal squamous cell carcinoma
Prenylated Rab acceptor 1 domain family, member 2 (PRAF2) is involved in the occurrence and progression of several malignant tumors. However, its potential role in esophageal squamous cell carcinoma (ESCC) is ... (Source: BMC Cancer)
Source: BMC Cancer - June 14, 2019 Category: Cancer & Oncology Authors: Zhaoye Qian, Bin Wei, Yu Zhou, Qiuzi Wang, Jiru Wang, Yuan Sun, Yong Gao and Xiaofei Chen Tags: Research article Source Type: research

Two open-label, single arm, non-randomized phase II studies of irinotecan for the treatment of metastatic breast cancer in patients with increased copy number of the topoisomerase I gene
Treatment options in metastatic breast cancer are limited. New therapies preferable with predictive biomarkers are needed. The aim of these trials was to investigate if gene copy number of the topoisomerase 1 ... (Source: BMC Cancer)
Source: BMC Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Iben K ümler, Eva Balslev, Jan Stenvang, Nils Brünner, Bent Ejlertsen, Erik Hugger Jakobsen and Dorte Lisbet Nielsen Tags: Research article Source Type: research

Thyroid transcription factor-1 as a prognostic indicator for stage IV lung adenocarcinoma with and without EGFR-sensitizing mutations
Thyroid transcription factor (TTF)-1 expression is a diagnostic marker and a good prognostic indicator for lung adenocarcinoma. However, its good prognostic ability might be due to epidermal growth factor rece... (Source: BMC Cancer)
Source: BMC Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Ji Young Park, Seung Hun Jang, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung, Jinwon Seo, Chang Youl Lee, Yousang Ko and Yong-Bum Park Tags: Research article Source Type: research

Treatment with somatostatin analogs induces differentially expressed let-7c-5p and mir-3137 in small intestine neuroendocrine tumors
Distant metastases frequently occur in gastroenteropancreatic neuroendocrine tumors. If hepatic surgery is not feasible, patients are treated with somatostatin analogs. However, the underlying mechanisms of ac... (Source: BMC Cancer)
Source: BMC Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Florian B ösch, Alexandr V. Bazhin, Sabine Heublein, Katharina Brüwer, Thomas Knösel, Florian P. Reiter, Christoph J. Auernhammer, Markus O. Guba, Christine Spitzweg, Jens Werner and Martin K. Angele Tags: Research article Source Type: research

Health-related quality of life in patients receiving first-line eribulin mesylate with or without trastuzumab for locally recurrent or metastatic breast cancer
Eribulin mesylate is a nontaxane microtubule dynamics inhibitor approved for second-line (European Union) or third-line (United States) treatment of metastatic breast cancer. Two phase 2 single trials, evaluat... (Source: BMC Cancer)
Source: BMC Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Lee Schwartzberg, Kristi McIntyre, Sharon Wilks, Shannon Puhalla, Joyce O ’Shaughnessy, Erhan Berrak, Yaohua He and Linda Vahdat Tags: Research article Source Type: research

Monitoring of circulating tumor DNA and its aberrant methylation in the surveillance of surgical lung Cancer patients: protocol for a prospective observational study
Detection of circulating tumor DNA (ctDNA) is a promising method for postoperative surveillance of lung cancer. However, relatively low positive rate in early stage patients restricts its application. Aberrant... (Source: BMC Cancer)
Source: BMC Cancer - June 13, 2019 Category: Cancer & Oncology Authors: Guannan Kang, Kezhong Chen, Fan Yang, Shannon Chuai, Heng Zhao, Kai Zhang, Bingsi Li, Zhihong Zhang and Jun Wang Tags: Study protocol Source Type: research

Complete response with early introduction of cabazitaxel in a patient with multiple lung metastases of castration-resistant prostate cancer following the early detection of metastases using liquid biopsy: a case report
Cabazitaxel (CBZ) chemotherapy for metastatic castration-resistant prostate cancer (mCRPC) is believed to be palliative because the radiological response rate is low and a durable response is rare. Here, we de... (Source: BMC Cancer)
Source: BMC Cancer - June 11, 2019 Category: Cancer & Oncology Authors: Takeo Kosaka, Hiroshi Hongo and Mototsugu Oya Tags: Case report Source Type: research

Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes
Circular RNAs (circRNAs) that form through non-canonical backsplicing events of pre-mRNA transcripts are evolutionarily conserved and abundantly expressed across species. However, the functional relevance of c... (Source: BMC Cancer)
Source: BMC Cancer - June 11, 2019 Category: Cancer & Oncology Authors: Thasni Karedath, Ikhlak Ahmed, Wafa Al Ameri, Fatima M. Al-Dasim, Simeon S. Andrews, Samson Samuel, Iman K. Al-Azwani, Yasmin Ali Mohamoud, Arash Rafii and Joel A. Malek Tags: Research article Source Type: research

Cancer stigma and cancer screening attendance: a population based survey in England
Cancer-related stigma attracts considerable research interest, but few studies have examined stigmatisation in the healthy population. Qualitative studies suggest that stigma can discourage people from attendi... (Source: BMC Cancer)
Source: BMC Cancer - June 11, 2019 Category: Cancer & Oncology Authors: Charlotte Vrinten, Ailish Gallagher, Jo Waller and Laura A. V. Marlow Tags: Research article Source Type: research

Long term response on Regorafenib in non-V600E BRAF mutated colon cancer: a case report
Non-V600E BRAF mutated colorectal cancer (CRC) is a rare disease entity with specific clinical features. These tumors are less likely to have microsatellite instability than CRC with a V600E BRAF mutation and oft... (Source: BMC Cancer)
Source: BMC Cancer - June 11, 2019 Category: Cancer & Oncology Authors: Eduard Callebout, Suzane Moura Ribeiro, Stephanie Laurent, Marc De Man, Liesbeth Ferdinande, Kathleen B. M. Claes, Joni Van der Meulen and Karen P. Geboes Tags: Case report Source Type: research

A prospective clinical trial on sorafenib treatment of hepatocellular carcinoma before liver transplantation
Patients with hepatocellular carcinoma waiting for liver transplantation are commonly treated with locoregional treatments, such as TACE and ablation, to prevent tumor progression and dropout and to improve lo... (Source: BMC Cancer)
Source: BMC Cancer - June 11, 2019 Category: Cancer & Oncology Authors: Malin Sternby Eilard, Mats Andersson, Peter Naredi, Charalampos Geronymakis, Per Lindn ér, Christian Cahlin, William Bennet and Magnus Rizell Tags: Research article Source Type: research

Aberrant expression of N-glycolyl GM3 ganglioside is associated with the aggressive biological behavior of human sarcomas
The aberrant expression of N-glycolyl GM3 ganglioside (NeuGcGM3) in patients with sarcomas was reevaluated by assessing the relation of this molecule with some clinicopathological features and overall survival... (Source: BMC Cancer)
Source: BMC Cancer - June 10, 2019 Category: Cancer & Oncology Authors: Daniel Pilco-Janeta, Myriam De la Cruz Puebla, Jorge Soriano, Marta Osorio, Iraida Caballero, Adanays Calvo P érez, Laynes Savon, Natalia Cremades, Rancés Blanco and Adriana Carr Tags: Research article Source Type: research

Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification
Published genetic risk scores for breast cancer (BC) so far have been based on a relatively small number of markers and are not necessarily using the full potential of large-scale Genome-Wide Association Studi... (Source: BMC Cancer)
Source: BMC Cancer - June 10, 2019 Category: Cancer & Oncology Authors: Kristi L äll, Maarja Lepamets, Marili Palover, Tõnu Esko, Andres Metspalu, Neeme Tõnisson, Peeter Padrik, Reedik Mägi and Krista Fischer Tags: Research article Source Type: research

Immune-related adverse events associated with programmed cell death protein-1 and programmed cell death ligand 1 inhibitors for non-small cell lung cancer: a PRISMA systematic review and meta-analysis
Programmed cell death protein-1 (PD-1) and programmed cell death ligand 1 (PD-L1) inhibitors have remarkable clinical efficacy in the treatment of non-small cell lung cancer (NSCLC); however, the breakdown of ... (Source: BMC Cancer)
Source: BMC Cancer - June 10, 2019 Category: Cancer & Oncology Authors: Xiaoying Sun, Raheleh Roudi, Ting Dai, Shangya Chen, Bin Fan, Hongjin Li, Yaqiong Zhou, Min Zhou, Bo Zhu, Chengqian Yin, Bin Li and Xin Li Tags: Research article Source Type: research

The safety and tolerability of combined immune checkpoint inhibitors (anti-PD-1/PD-L1 plus anti-CTLA-4): a systematic review and meta-analysis
The future of combined immunotherapy (a PD-1/PD-L1 plus a CTLA-4 antagonist) is very bright. However, besides improving efficacy, combined therapy increases treatment-related adverse events (TRAEs). Also, the ... (Source: BMC Cancer)
Source: BMC Cancer - June 10, 2019 Category: Cancer & Oncology Authors: Lihu Gu, Parikshit Asutosh Khadaroo, Hui Su, Liya Kong, Liangliang Chen, Xianfa Wang, Xinlong Li, Hepan Zhu, Xin Zhong, Junhai Pan and Manman Chen Tags: Research article Source Type: research

Radiotherapy for inferior vena cava tumor thrombus in patients with hepatocellular carcinoma
This study aimed to evaluate the outcome of HCC patients receiving radiotherapy (RT) to IVC tumor... (Source: BMC Cancer)
Source: BMC Cancer - June 10, 2019 Category: Cancer & Oncology Authors: Tzu-Hui Pao, Wei-Ting Hsueh, Wei-Lun Chang, Nai-Jung Chiang, Yih-Jyh Lin, Yi-Sheng Liu and Forn-Chia Lin Tags: Research article Source Type: research

Prognostic significance of serum aspartic transaminase in diffuse large B-cell lymphoma
Liver function is routinely assessed in clinical practice as liver function tests provide sensitive indicators of hepatocellular injury. However, the prognostic value of enzymes that indicate hepatic injury ha... (Source: BMC Cancer)
Source: BMC Cancer - June 8, 2019 Category: Cancer & Oncology Authors: Ting-Xun Lu, Shuang Wu, Dong-Yan Cai, Ting-Ting Hong, Ying Zhang, Hua-Qiang Gao, Hai-Ying Hua and Xiao-Hong Wu Tags: Research article Source Type: research

Advantages of using reduced-volume intensity modulated radiation therapy for the treatment of nasopharyngeal carcinoma: a retrospective paired study
The definition of clinical target volume (CTV) in intensity modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) has not been addressed. We performed this study to assess the feasibility and e... (Source: BMC Cancer)
Source: BMC Cancer - June 8, 2019 Category: Cancer & Oncology Authors: Fang Liu, Ting Luo, Tao Jin, Jiahui Zhang, Zhongzheng Xiang, Ruonan Yan, Li Xie, Xin Wu, Hong Zhang, Feng Wang, Ping Li and Lei Liu Tags: Research article Source Type: research

A prospective observational study to assess PD-L1 expression in small biopsy samples for non-small-cell lung cancer
Programmed cell death-1 (PD-1) immune checkpoint inhibitor antibody has proven to be effective in advanced non-small cell lung cancer (NSCLC) patients positive for programmed cell death-1 ligand-1 (PD-L1). How... (Source: BMC Cancer)
Source: BMC Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Akihito Tsunoda, Kei Morikawa, Takeo Inoue, Teruomi Miyazawa, Masahiro Hoshikawa, Masayuki Takagi and Masamichi Mineshita Tags: Research article Source Type: research

Impact of body mass index and fat distribution on sex steroid levels in endometrial carcinoma: a retrospective study
Obesity is an important cause of multiple cancer types, amongst which endometrial cancer (EC). The relation between obesity and cancer is complicated and involves alterations in insulin metabolism, response to... (Source: BMC Cancer)
Source: BMC Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Willem Jan van Weelden, Kristine Eldevik Fasmer, Ingvild L. Tangen, Joanna IntHout, Karin Abbink, Antionius E. van Herwaarden, Camilla Krakstad, Leon F. A. G. Massuger, Ingfrid S. Haldorsen and Johanna M. A. Pijnenborg Tags: Research article Source Type: research

Real-world treatment patterns and adverse events in metastatic renal cell carcinoma from a large US claims database
Vascular endothelial growth factor (VEGF), tyrosine kinase (TK) and mechanistic target of rapamycin kinase (mTOR) inhibitors are common first-line (1  L) treatments for metastatic renal cell carcinoma (mRCC). D... (Source: BMC Cancer)
Source: BMC Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Sumanta Pal, Jun Gong, Shivani K. Mhatre, Shih-Wen Lin, Andy Surinach, Sarika Ogale, Rini Vohra, Herschel Wallen and Daniel George Tags: Research article Source Type: research

Characterization of molecular scores and gene expression signatures in primary breast cancer, local recurrences and brain metastases
Breast cancer is a leading cause of cancer-related death in women worldwide. Despite extensive studies in all areas of basic, clinical and applied research, accurate prognosis remains elusive, thus leading to ... (Source: BMC Cancer)
Source: BMC Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Mariana Bustamante Eduardo, Vlad Popovici, Sara Imboden, Stefan Aebi, Nadja Ballabio, Hans J örg Altermatt, Andreas Günthert and Rolf Jaggi Tags: Research article Source Type: research

Comprehensive mutation detection of BRCA1/2 genes reveals large genomic rearrangements contribute to hereditary breast and ovarian cancer in Chinese women
Mutated BRCA1/2 genes are associated with hereditary breast and ovarian cancer (HBOC). So far most of the identified BRCA1/2 pathogenic variants are single nucleotide variants (SNVs) or insertions/deletions (Inde... (Source: BMC Cancer)
Source: BMC Cancer - June 7, 2019 Category: Cancer & Oncology Authors: Wen-Ming Cao, Ya-Bing Zheng, Yun Gao, Xiao-Wen Ding, Yan Sun, Yuan Huang, Cai-Jin Lou, Zhi-Wen Pan, Guang Peng and Xiao-Jia Wang Tags: Research article Source Type: research

Iron intake, body iron status, and risk of breast cancer: a systematic review and meta-analysis
Iron has been shown to promote breast carcinogenesis in animal models through generation of oxidative stress and interaction with estrogen. Heme iron, which is found exclusively in animal-sourced foods, is sug... (Source: BMC Cancer)
Source: BMC Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Vicky C. Chang, Michelle Cotterchio and Edwin Khoo Tags: Research article Source Type: research

Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors
The understanding of the molecular biology of pediatric neuronal and mixed neuronal-glial brain tumors is still insufficient due to low frequency and heterogeneity of those lesions which comprise several subty... (Source: BMC Cancer)
Source: BMC Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Magdalena Zakrzewska, Renata Gruszka, Konrad Stawiski, Wojciech Fendler, Joanna Kordacka, Wies ława Grajkowska, Paweł Daszkiewicz, Paweł P. Liberski and Krzysztof Zakrzewski Tags: Research article Source Type: research

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication
Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cy... (Source: BMC Cancer)
Source: BMC Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Sean K. Maynard, Jason D. Marshall, Randall S. MacGill, Li Yu, Jennifer A. Cann, Lily I. Cheng, Michael P. McCarthy, Corinne Cayatte and Scott H. Robbins Tags: Research article Source Type: research

Development and validation of nomograms predicting survival in Chinese patients with triple negative breast cancer
Triple negative breast cancer (TNBC) is an aggressive and heterogeneous disease. Nomograms predicting outcomes of TNBC are needed for risk management. (Source: BMC Cancer)
Source: BMC Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Yaping Yang, Ying Wang, Heran Deng, Cui Tan, Qian Li, Zhanghai He, Wei Wei, Enxiang Zhou, Qiang Liu and Jieqiong Liu Tags: Research article Source Type: research

Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells
The multi-functional BMCC1 (BCH motif-containing molecule at the carboxyl terminal region 1)/PRUNE2 plays a clear role in suppression of tumor activity. In the patients with neuroblastoma (NB), reduced express... (Source: BMC Cancer)
Source: BMC Cancer - June 6, 2019 Category: Cancer & Oncology Authors: Mohammad Sazzadul Islam, Ryo Takano, Tomoki Yokochi, Jesmin Akter, Yohko Nakamura, Akira Nakagawara and Yasutoshi Tatsumi Tags: Research article Source Type: research

Endurance training slows breast tumor growth in mice by suppressing Treg cells recruitment to tumors
Aerobic exercise has been shown to slow tumor progression in rodents and humans, but the mechanisms behind this effect are still unclear. Here we show that aerobic exercise in the form of chronic endurance tra... (Source: BMC Cancer)
Source: BMC Cancer - June 4, 2019 Category: Cancer & Oncology Authors: Amit Hagar, Zemin Wang, Sachiko Koyama, Josua Aponte Serrano, Luma Melo, Stephanie Vargas, Richard Carpenter and John Foley Tags: Research article Source Type: research

Intracranial aneurysms formation after radiotherapy for head and neck cancer: a 10-year nationwide follow-up study
Intracranial aneurysms after radiotherapy (RT) have previously been reported. However, the majority of studies were case reports. Therefore, we performed a nationwide study to explore the risk of radiation-ind... (Source: BMC Cancer)
Source: BMC Cancer - June 4, 2019 Category: Cancer & Oncology Authors: Wei-Hsun Yang, Yao-Hsu Yang, Pau-Chung Chen, Ting-Chung Wang, Ko-Jung Chen, Chun-Yu Cheng and Chia-Hsuan Lai Tags: Research article Source Type: research

Clinical and prognostic implications of pretreatment albumin to C-reactive protein ratio in patients with hepatocellular carcinoma
Despite recent advances in the treatments of hepatocellular carcinoma (HCC), the prognosis of HCC patients remains controversial. The purpose of this study was to investigate the prognostic performance of pret... (Source: BMC Cancer)
Source: BMC Cancer - June 4, 2019 Category: Cancer & Oncology Authors: Mian-Tao Wu, Su-Yin He, Shu-Lin Chen, Lin-Fang Li, Zheng-Qiang He, Yuan-Ying Zhu, Xia He and Hao Chen Tags: Research article Source Type: research

Diffuse lichen planus-like keratoses and clinical pseudo-progression associated with avelumab treatment for Merkel cell carcinoma, a case report
Avelumab is an anti-programmed cell death ligand 1 (PD-L1) antibody approved for treatment of Merkel cell carcinoma (MCC) and locally advanced or metastatic urothelial carcinoma. It shares a similar side effec... (Source: BMC Cancer)
Source: BMC Cancer - June 4, 2019 Category: Cancer & Oncology Authors: Michael A. Cardis, Hong Jiang, Julius Strauss, James L. Gulley and Isaac Brownell Tags: Case report Source Type: research

A novel long non-coding RNA from the HOXA6-HOXA5 locus facilitates colon cancer cell growth
Homeobox A5 (HOXA5), a member of the HOX family, plays an important role in tumor development and morphogenesis, although opposite effects on tumorigenesis have been observed, depending on the tissue type. In ... (Source: BMC Cancer)
Source: BMC Cancer - June 3, 2019 Category: Cancer & Oncology Authors: Saki Saijo, Yuki Kuwano, Shoichiro Tange, Kazuhito Rokutan and Kensei Nishida Tags: Research article Source Type: research

First-line single-agent regorafenib in frail patients with metastatic colorectal cancer: a pilot phase II study of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD)
Treatment of frail patients with advanced colorectal cancer (CRC) is controversial. This pilot phase II trial aimed to assess the efficacy and safety of regorafenib when administered in first-line to frail pat... (Source: BMC Cancer)
Source: BMC Cancer - June 3, 2019 Category: Cancer & Oncology Authors: A. Carrato, M. Benavides, B. Massut í, R. Ferreiro-Monteagudo, P. García Alfonso, E. Falcó, M. Reboredo, T. Cano, J. Gallego, J. M. Viéitez, L. Layos, A. Salud, E. Polo, E. Dotor, G. Durán-Ogalla, M. Rodriguez-Garrote & hellip; Tags: Research article Source Type: research

Prevalence and prognostic value of FBXO11 expression in patients with clear cell renal cell carcinoma
FBXO11, a member of the F-box protein family, regulates the cell-cycle by promoting the degradation of Bcl-6 and p53. This protein has been implicated in the progression of several cancers, including renal cel... (Source: BMC Cancer)
Source: BMC Cancer - June 3, 2019 Category: Cancer & Oncology Authors: Bo Fan, Wei Wang, Xianping Zhang, Min Sun, Xiaogang Wang, Zhiqi Chen, Wankai Liu, Qun Wang, Na Yu and Xiancheng Li Tags: Research article Source Type: research

Analysis of hereditary cancer syndromes by using a panel of genes: novel and multiple pathogenic mutations
Hereditary cancer predisposition syndromes are responsible for approximately 5 –10% of all diagnosed cancer cases. In the past, single-gene analysis of specific high risk genes was used for the determination of... (Source: BMC Cancer)
Source: BMC Cancer - June 3, 2019 Category: Cancer & Oncology Authors: Georgios N. Tsaousis, Eirini Papadopoulou, Angela Apessos, Konstantinos Agiannitopoulos, Georgia Pepe, Stavroula Kampouri, Nikolaos Diamantopoulos, Theofanis Floros, Rodoniki Iosifidou, Ourania Katopodi, Anna Koumarianou, Christos Markopoulos, Konstantino Tags: Research article Source Type: research

Early prostate-specific antigen response post-abiraterone as predictor of overall survival in metastatic castrate-resistant prostate cancer
Abiraterone is an important agent in the treatment of advanced prostate cancer. Early changes in prostate-specific antigen while on abiraterone in patients with metastatic castrate-resistant prostate cancer po... (Source: BMC Cancer)
Source: BMC Cancer - May 31, 2019 Category: Cancer & Oncology Authors: Joshua P. Schiff, Patrick Cotogno, Allison Feibus, Peter Steinwald, Elisa Ledet, Brian Lewis and Oliver Sartor Tags: Research article Source Type: research

Clinical use of tumor biomarkers in prediction for prognosis and chemotherapeutic effect in esophageal squamous cell carcinoma
Growing evidence has indicated that tumor biomarkers, including cytokeratin 19 fragment antigen 21 –1 (Cyfra21–1), carbohydrate antigen 19–9 (CA19–9), carbohydrate antigen 72–4 (CA72–4), carcinoembryonic antige... (Source: BMC Cancer)
Source: BMC Cancer - May 31, 2019 Category: Cancer & Oncology Authors: Yuchong Yang, Xuanzhang Huang, Likun Zhou, Ting Deng, Tao Ning, Rui Liu, Le Zhang, Ming Bai, Haiyang Zhang, Hongli Li and Yi Ba Tags: Research article Source Type: research

The effect of diabetes on the risk of endometrial Cancer: an updated a systematic review and meta-analysis
Previous studies conducted on the association between diabetes and the risk of endometrial cancer have reported controversial results that have raised a variety of questions about the association between diabe... (Source: BMC Cancer)
Source: BMC Cancer - May 31, 2019 Category: Cancer & Oncology Authors: Lotfolah Saed, Fatemeh Varse, Hamid Reza Baradaran, Yousef Moradi, Sorour Khateri, Emilie Friberg, Zaher Khazaei, Saeedeh Gharahjeh, Shahrzad Tehrani, Amir-Babak Sioofy-Khojine and Zahra Najmi Tags: Research article Source Type: research

K-ras-ERK1/2 down-regulates H2A.XY142ph through WSTF to promote the progress of gastric cancer
Histone H2AX phosphorylation at the site of Tyr-142 can participates in multiple biological progressions, which is including DNA repair. Ras pathway is closely involved in human cancers. Our study investigated... (Source: BMC Cancer)
Source: BMC Cancer - May 31, 2019 Category: Cancer & Oncology Authors: Chao Dong, Jing Sun, Sha Ma and Guoying Zhang Tags: Research article Source Type: research

Elevated X-linked inhibitor of apoptosis protein (XIAP) expression uncovers detrimental prognosis in subgroups of neoadjuvant treated and T-cell rich esophageal adenocarcinoma
Molecular markers predicting survival in esophageal adenocarcinoma (EAC) are rare. Specifically, in favorable oncologic situations, e.g. nodal negativity or major neoadjuvant therapy response, there is a lack ... (Source: BMC Cancer)
Source: BMC Cancer - May 31, 2019 Category: Cancer & Oncology Authors: Lars M. Schiffmann, Heike G öbel, Heike Löser, Fabian Schorn, Jan Paul Werthenbach, Hans F. Fuchs, Patrick S. Plum, Marc Bludau, Thomas Zander, Wolfgang Schröder, Christiane J. Bruns, Hamid Kashkar, Alexander Quaas and Florian Gebauer Tags: Research article Source Type: research

Lineage relationship between prostate adenocarcinoma and small cell carcinoma
Prostate cancer displays different morphologies which, in turn, affect patient outcome. This fact prompted questions about the lineage relationship between differentiated, more treatable prostate adenocarcinom... (Source: BMC Cancer)
Source: BMC Cancer - May 30, 2019 Category: Cancer & Oncology Authors: Adelle D. Kanan, Eva Corey, Ricardo Z. N. V êncio, Arjun Ishwar and Alvin Y. Liu Tags: Research article Source Type: research

Intracranial antitumor responses of nivolumab and ipilimumab: a pharmacodynamic and pharmacokinetic perspective, a scoping systematic review
Recently, two phase II trials showed intracranial activity of the immune checkpoint inhibitors nivolumab and ipilimumab in patients with melanoma brain metastases. However, it is generally assumed that large m... (Source: BMC Cancer)
Source: BMC Cancer - May 30, 2019 Category: Cancer & Oncology Authors: Mark T. J. van Bussel, Jos H. Beijnen and Dieta Brandsma Tags: Research article Source Type: research

Risk of loco-regional recurrence and distant metastases of patients with invasive breast cancer up to ten years after diagnosis – results from a registry-based study from Germany
Population-based estimates of the long-term risk of loco-regional recurrence and distant metastases of breast cancer (BRC) patients are scant, as most published studies used hospital-based cohorts or participa... (Source: BMC Cancer)
Source: BMC Cancer - May 30, 2019 Category: Cancer & Oncology Authors: Bernd Holleczek, Christa Stegmaier, Julia C. Radosa, Erich-Franz Solomayer and Hermann Brenner Tags: Research article Source Type: research

Array comparative genomic hybridization analysis discloses chromosome copy number alterations as indicators of patient outcome in lymph node-negative breast cancer
Patients with lymph node metastasis-negative (pN0) invasive breast cancer have favorable outcomes following initial treatment. However, false negatives which occur during routine histologic examination of lymp... (Source: BMC Cancer)
Source: BMC Cancer - May 30, 2019 Category: Cancer & Oncology Authors: Ryoko Kikuchi-Koike, Kazunori Nagasaka, Hitoshi Tsuda, Yasuyuki Ishii, Masaru Sakamoto, Yoshihiro Kikuchi, Shiho Fukui, Yuko Miyagawa, Haruko Hiraike, Takayuki Kobayashi, Takayuki Kinoshita, Yae Kanai, Tatsuhiro Shibata, Issei Imoto, Johji Inazawa, Osamu Tags: Research article Source Type: research