Early experience with sequential intravesical gemcitabine and docetaxel for micropapillary variant non-muscle invasive bladder cancer
CONCLUSIONS: Gem/Doce with Val/Doce rescue appears to have activity against carefully selected non-muscle invasive MPUC with favorable histology. Larger prospective trials are needed to validate these results.PMID:38796357 | DOI:10.1016/j.urolonc.2024.05.006 (Source: Urologic Oncology)
Source: Urologic Oncology - May 25, 2024 Category: Urology & Nephrology Authors: Mohamad Abou Chakra Ian M McElree Vignesh T Packiam Sarah L Mott Michael A O'Donnell Source Type: research
Squamous cell carcinoma and basal cell carcinoma of the lips: 25 years of experience in a northeast Brazilian population
CONCLUSIONS: SCC was more frequent in male patients, while BCC showed more frequency in female patients. Both neoplasms mainly affect the lower lip. Understanding the epidemiological profile of these lesions in the lip, as well as their etiology and clinical features, is fundamental for appropriate clinical conduct and the creation and/or amplification of preventive measures.PMID:38794936 | DOI:10.4317/medoral.26454 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - May 25, 2024 Category: ENT & OMF Authors: W-R Silva M-M Bortoli S-R Leite C-C Barros M-D Brito L-T Montenegro R-J Vasconcellos D-P Iglesias A-P Sobral Source Type: research
Salivary cortisol levels in patients with potentially malignant oral disorders and oral mucosal cancer: a case-control study
CONCLUSIONS: The increase in salivary cortisol levels in patients with PMD and SCC, is related to stress conditions, being able to generate alterations tending to immunosuppression of the cellular microenvironment.PMID:38794939 | DOI:10.4317/medoral.26606 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - May 25, 2024 Category: ENT & OMF Authors: E L ópez-D'alessandro J Palomino L Escovich Source Type: research
Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study
CONCLUSIONS: To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians' inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies.PMID:38794942 | DOI:10.4317/medoral.26551 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - May 25, 2024 Category: ENT & OMF Authors: C Saldivia-Siracusa A-L Ara újo L-P Arboleda T Abrantes M-B Pinto N Mendon ça K Cordero-Torres G Gilligan E Piemonte R Panico F De-Abreu- Álves M Villaroel-Dorrego Source Type: research
Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations
In this study, the most common South Asian variants of NEIL1 were expressed, purified, and functionally characterized. All tested variants exhibited activities and substrate specificities similar to wild type (wt)-NEIL1 on high-molecular weight DNA containing an array of oxidatively-induced base lesions. On short oligodeoxynucleotides (17-mers) containing either a site-specific apurinic/apyrimidinic (AP) site, thymine glycol (ThyGly), or AFB1-FapyGua, P206L-NEIL1 was catalytically comparable to wt-NEIL1, while the activities of NEIL1 variants Q67K and T278I on these substrates were ≈2-fold reduced. Variant T103A had a gr...
Source: DNA Repair - May 25, 2024 Category: Genetics & Stem Cells Authors: Jamie T Zuckerman Asia Sage Jackson Irina G Minko Melis Kant Pawel Jaruga Michael P Stone Miral Dizdaroglu Amanda K McCullough R Stephen Lloyd Source Type: research
Phospholipid isotope tracing suggests β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 May 23:159514. doi: 10.1016/j.bbalip.2024.159514. Online ahead of print.ABSTRACTActivating mutations in the CTNNB1 gene encoding β-catenin are among the most frequently observed oncogenic alterations in hepatocellular carcinoma (HCC). Profound alterations in lipid metabolism, including increases in fatty acid oxidation and transformation of the phospholipidome, occur in HCC with CTNNB1 mutations, but it is unclear what mechanisms give rise to these changes. We employed untargeted lipidomics and targeted isotope tracing to measure phospholipid synthesis activity in an inducib...
Source: Biochimica et Biophysica Acta - May 25, 2024 Category: Biochemistry Authors: Chad VanSant-Webb Hayden K Low Junko Kuramoto Claire E Stanley Hantao Qiang Audrey Su Alexis N Ross Chad G Cooper James E Cox Scott A Summers Kimberley J Evason Gregory S Ducker Source Type: research
Retraction Note: The role of substance P/neurokinin 1 receptor in the pathogenesis of esophageal squamous cell carcinoma through constitutively active PI3K/Akt/NF- κB signal transduction pathways
Mol Biol Rep. 2024 May 25;51(1):696. doi: 10.1007/s11033-024-09649-5.NO ABSTRACTPMID:38796604 | DOI:10.1007/s11033-024-09649-5 (Source: Molecular Biology Reports)
Source: Molecular Biology Reports - May 25, 2024 Category: Molecular Biology Authors: Hossein Javid Jahanbakhsh Asadi Farnaz Zahedi Avval Amir R Afshari Seyed Isaac Hashemy Source Type: research
Clinicopathologic Analysis and Prognostic Factors for Survival in Patients with Operable Ampullary Carcinoma: A Multi-Institutional Retrospective Experience
Conclusions: Nodal status and a positive surgical margin were independent predictors of a poor mOS for patients with ampullary carcinomas. Additional studies are required to explore the role of adjuvant therapy in patients with ampullary carcinomas.PMID:38793001 | PMC:PMC11122928 | DOI:10.3390/medicina60050818 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - May 25, 2024 Category: Universities & Medical Training Authors: Nebi Serkan Demirci Eyyup Cavdar Nuriye Yildirim Ozdemir Sinemis Yuksel Yakup Iriagac Gokmen Umut Erdem Hatice Odabas Ilhan Hacibekiroglu Mustafa Karaagac Mahmut Ucar Banu Ozturk Yakup Bozkaya Source Type: research
BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations
Medicina (Kaunas). 2024 May 10;60(5):793. doi: 10.3390/medicina60050793.ABSTRACTBreast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging neoplastic complications related to breast implants. While BIA-ALCL is often linked to macrotextured implants, current evidence does not suggest an implant-type association for BIA-SCC. Chronic inflammation and genetics have been hypothesized as key pathogenetic players, although for both conditions, the exact mechanisms and specific risks related to breast implants are yet to be established. While the...
Source: Medicina (Kaunas) - May 25, 2024 Category: Universities & Medical Training Authors: Gennaro D'Orsi Martina Giacalone Alessio Calicchia Elettra Gagliano Lisa Vannucchi Gianluca Vanni Oreste Claudio Buonomo Valerio Cervelli Benedetto Longo Source Type: research
Estimating the long-term survival of unresectable stage III non-small cell lung cancer based on cure model analysis
CONCLUSIONS: Radiotherapy, especially when combined with ICIs, offers a potential cure for a proportion of patients with unresectable stage III NSCLC. Tumor burden and ICIs are key predictors of long-term survival. The study suggested 4-year PFS and 5-year OS as surrogate endpoints for cure and long-term survival assessment.PMID:38795813 | DOI:10.1016/j.radonc.2024.110341 (Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology)
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - May 25, 2024 Category: Radiology Authors: Yunpeng Wu Ying Jiang Wenqing Wang Tao Zhang Yexiong Li Supervisio Nan Bi Source Type: research
Chitosan-modified manganese oxide-conjugated methotrexate nanoparticles delivering 5-aminolevulinic acid as a dual-modal T1-T2* MRI contrast agent in U87MG cell detection
CONCLUSION: This developed MnO2/CS@5-ALA-MTX nanoparticle system may exhibit great potential in the accurate diagnosis of folate receptor over-expressing cancers such as glioblastoma.PMID:38795276 | DOI:10.1007/s10334-024-01169-4 (Source: Magma)
Source: Magma - May 25, 2024 Category: Radiology Authors: Yasin Ayyami Marjan Ghorbani Masoumeh Dastgir Reza Malekzadeh Tohid Mortezazadeh Source Type: research
Multimodal Therapy Approaches for NUT Carcinoma by Dual Combination of Oncolytic Virus < em > Talimogene Laherparepvec < /em > with Small Molecule Inhibitors
Viruses. 2024 May 14;16(5):775. doi: 10.3390/v16050775.ABSTRACTNUT (nuclear-protein-in-testis) carcinoma (NC) is a highly aggressive tumor disease. Given that current treatment regimens offer a median survival of six months only, it is likely that this type of tumor requires an extended multimodal treatment approach to improve prognosis. In an earlier case report, we could show that an oncolytic herpes simplex virus (T-VEC) is functional in NC patients. To identify further combination partners for T-VEC, we have investigated the anti-tumoral effects of T-VEC and five different small molecule inhibitors (SMIs) alone and in ...
Source: Herpes - May 25, 2024 Category: Infectious Diseases Authors: Stavros Sotiriadis Julia Beil Susanne Berchtold Irina Smirnow Andrea Schenk Ulrich M Lauer Source Type: research
Salivary cortisol levels in patients with potentially malignant oral disorders and oral mucosal cancer: a case-control study
CONCLUSIONS: The increase in salivary cortisol levels in patients with PMD and SCC, is related to stress conditions, being able to generate alterations tending to immunosuppression of the cellular microenvironment.PMID:38794939 | DOI:10.4317/medoral.26606 (Source: Cancer Control)
Source: Cancer Control - May 25, 2024 Category: Cancer & Oncology Authors: E L ópez-D'alessandro J Palomino L Escovich Source Type: research
Pilot study for bladder cancer detection with volatile organic compounds using ion mobility spectrometry: a novel urine-based approach
CONCLUSION: VOC-based detection of bladder cancer is feasible. MCC/IMS is a suitable method for urine-based diagnosis and should be further validated. The molecular characteristics and metabolic background of the analytes require further workup.PMID:38795133 | DOI:10.1007/s00345-024-05047-5 (Source: Cancer Control)
Source: Cancer Control - May 25, 2024 Category: Cancer & Oncology Authors: Hendrik Heers Josef Maximilian Gut Rainer Hofmann Luka Flegar Marcus Derigs Johannes Huber Joerg Ingo Baumbach Andreas Rembert Koczulla Tobias Boeselt Source Type: research
Multimodal Therapy Approaches for NUT Carcinoma by Dual Combination of Oncolytic Virus < em > Talimogene Laherparepvec < /em > with Small Molecule Inhibitors
Viruses. 2024 May 14;16(5):775. doi: 10.3390/v16050775.ABSTRACTNUT (nuclear-protein-in-testis) carcinoma (NC) is a highly aggressive tumor disease. Given that current treatment regimens offer a median survival of six months only, it is likely that this type of tumor requires an extended multimodal treatment approach to improve prognosis. In an earlier case report, we could show that an oncolytic herpes simplex virus (T-VEC) is functional in NC patients. To identify further combination partners for T-VEC, we have investigated the anti-tumoral effects of T-VEC and five different small molecule inhibitors (SMIs) alone and in ...
Source: Cancer Control - May 25, 2024 Category: Cancer & Oncology Authors: Stavros Sotiriadis Julia Beil Susanne Berchtold Irina Smirnow Andrea Schenk Ulrich M Lauer Source Type: research
