CAMSAP3-mediated regulation of HMGB1 acetylation and subcellular localization in lung cancer cells: Implications for cell death modulation
CONCLUSIONS: CAMSAP3 is prerequisite for TSA-mediated autophagic cell death by interacting with cytoplasmic acetylated HMGB1 and enhancing its release.SIGNIFICANT: This finding provides molecular insights into the role of CAMSAP3 in regulating cell death, highlighting its potential as a therapeutic target for lung cancer treatment.PMID:38598971 | DOI:10.1016/j.bbagen.2024.130614 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Natsaranyatron Singharajkomron Suthasinee Seephan Iksen Iksen Naphat Chantaravisoot Piriya Wongkongkathep Yoshihiro Hayakawa Varisa Pongrakhananon Source Type: research

Metabolic adaptations in cancer stem cells: A key to therapy resistance
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167164. doi: 10.1016/j.bbadis.2024.167164. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor growth and cause recurrence and metastasis. CSCs are particularly resistant to conventional therapies compared to their counterparts, owing greatly to their intrinsic metabolic plasticity. Metabolic plasticity allows CSCs to switch between different energy production and usage pathways based on environmental and extrinsic factors, including conditions imposed by conventional cancer therapies. To cope with nutrient dep...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Matthew Masoudi Dilpreet Moti Raha Masoudi Abdul Auwal M Matakabbir Hossain Tasfik Ul Haque Pronoy Khan Mohammad Rashel Vinod Gopalan Farhadul Islam Source Type: research

The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167161. doi: 10.1016/j.bbadis.2024.167161. Online ahead of print.ABSTRACTThe tongue epithelium is maintained by a proliferative basal layer. This layer contains long-lived stem cells (SCs), which produce progeny cells that move up to the surface as they differentiate. B-lymphoma Mo-MLV insertion region 1 (Bmi1), a protein in mammalian Polycomb Repressive Complex 1 (PRC1) and a biomarker of oral squamous cell carcinoma, is expressed in almost all basal epithelial SCs of the tongue, and single, Bmi1-labelled SCs give rise to cells in all epithelial layers. We previously develope...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Jorge Baquero Xiao-Han Tang Annalisa Ferrotta Tuo Zhang Krysta M DiKun Lorraine J Gudas Source Type: research

Transcriptomic analysis identifies dysregulated pathways and therapeutic targets in PMM2-CDG
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167163. doi: 10.1016/j.bbadis.2024.167163. Online ahead of print.ABSTRACTPMM2-CDG (MIM # 212065), the most common congenital disorder of glycosylation, is caused by the deficiency of phosphomannomutase 2 (PMM2). It is a multisystemic disease of variable severity that particularly affects the nervous system; however, its molecular pathophysiology remains poorly understood. Currently, there is no effective treatment. We performed an RNA-seq based transcriptomic study using patient-derived fibroblasts to gain insight into the mechanisms underlying the clinical symptomatology and ...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Diana Gallego Mercedes Serrano Jose Cordoba-Caballero Alejandra G ámez Pedro Seoane James R Perkins Juan A G Ranea Bel én Pérez Source Type: research

Iron ‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections
Biochim Biophys Acta Mol Cell Res. 2024 Apr 8:119723. doi: 10.1016/j.bbamcr.2024.119723. Online ahead of print.ABSTRACTViruses have evolved complex mechanisms to exploit host factors for replication and assembly. In response, host cells have developed strategies to block viruses, engaging in a continuous co-evolutionary battle. This dynamic interaction often revolves around the competition for essential resources necessary for both host cell and virus replication. Notably, iron, required for the biosynthesis of several cofactors, including iron‑sulfur (FeS) clusters, represents a critical element in the ongoing competiti...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Nunziata Maio Audrey L Heffner Tracey A Rouault Source Type: research

Molecular dynamics of structural effects of reactive carbonyl species derivate of lipid peroxidation on bovine serum albumin
CONCLUSIONS: RCSs induces local structural changes on mono‑carbonylated BSA. Also, this study extends our knowledge on how carbonylation by RCSs induce structural effects on proteins.PMID:38593934 | DOI:10.1016/j.bbagen.2024.130613 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 9, 2024 Category: Biochemistry Authors: Rafael Pineda-Alem án Camila Cabarcas-Herrera Antistio Alviz-Amador Rodrigo Galindo-Murillo Humberto P érez-Gonzalez Erika Rodr íguez-Cavallo Dar ío Méndez-Cuadro Source Type: research

Molecular dynamics of structural effects of reactive carbonyl species derivate of lipid peroxidation on bovine serum albumin
CONCLUSIONS: RCSs induces local structural changes on mono‑carbonylated BSA. Also, this study extends our knowledge on how carbonylation by RCSs induce structural effects on proteins.PMID:38593934 | DOI:10.1016/j.bbagen.2024.130613 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 9, 2024 Category: Biochemistry Authors: Rafael Pineda-Alem án Camila Cabarcas-Herrera Antistio Alviz-Amador Rodrigo Galindo-Murillo Humberto P érez-Gonzalez Erika Rodr íguez-Cavallo Dar ío Méndez-Cuadro Source Type: research

Cholesterol 25-hydroxylase prevents type 2 diabetes mellitus induced cardiomyopathy by alleviating cardiac lipotoxicity
CONCLUSION: Our study provides compelling evidence supporting the protective role of CH25H in T2DM-induced cardiomyopathy. Furthermore, the regulation of PGC-1α may be intricately involved in this cardioprotective process.PMID:38588780 | DOI:10.1016/j.bbadis.2024.167158 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 8, 2024 Category: Biochemistry Authors: Jialiang Zhang Hao Zhou Fan Lei Kexin Jiang Yanbiao Liao Fangyang Huang Mao Chen Source Type: research

Femtosecond optical studies of the primary charge separation reactions in far-red photosystem II from Synechococcus sp. PCC 7335
Biochim Biophys Acta Bioenerg. 2024 Apr 6:149044. doi: 10.1016/j.bbabio.2024.149044. Online ahead of print.ABSTRACTPrimary processes of light energy conversion by Photosystem II (PSII) were studied using femtosecond broadband pump-probe absorption difference spectroscopy. Transient absorption changes of core complexes isolated from the cyanobacterium Synechococcus sp. PCC 7335 grown under far-red light (FRL-PSII) were compared with the canonical Chl a containing spinach PSII core complexes upon excitation into the red edge of the Qy band. Absorption changes of FRL-PSII were monitored at 278 K in the 400-800 nm spectral ran...
Source: Biochimica et Biophysica Acta - April 8, 2024 Category: Biochemistry Authors: Dmitry A Cherepanov Vasily Kurashov Fedor E Gostev Ivan V Shelaev Alexey A Zabelin Gaozhong Shen Mahir D Mamedov Arseny Aybush Anatoly Ya Shkuropatov Victor A Nadtochenko Donald A Bryant John H Golbeck Alexey Yu Semenov Source Type: research

Bioconcentration potential of ionic liquids: New data on membrane partitioning and its comparison with predictions obtained by COSMOmic
Biochim Biophys Acta Biomembr. 2024 Apr 5:184320. doi: 10.1016/j.bbamem.2024.184320. Online ahead of print.ABSTRACTIonic liquids (ILs) have recently gained significant attention in both the scientific community and industry, but there is a limited understanding of the potential risks they might pose to the environment and human health, including their potential to accumulate in organisms. While membrane and storage lipids have been considered as primary sorption phases driving bioaccumulation, in this study we used an in vitro tool known as solid-supported lipid membranes (SSLMs) to investigate the affinity of ILs to membr...
Source: Biochimica et Biophysica Acta - April 7, 2024 Category: Biochemistry Authors: Jakub Maculewicz Anna Bia łk-Bielińska Dorota Kowalska Piotr Stepnowski Stefan Stolte Stephan Beil Agnieszka Gajewicz-Skretna Joanna Do łżonek Source Type: research

GLUT3 transcriptional activation by ZEB1 fuels the Warburg effect and promotes ovarian cancer progression
This study explores the role of glucose transporter 3 (GLUT3) driven by zinc finger E-box-binding homeobox 1 (ZEB1) in OvCa progression and metastasis. Specifically, this study explored whether ZEB1 promotes glycolysis and assessed the potential involvement of GLUT3 in this process in OvCa cells. Our findings revealed that ZEB1 and GLUT3 were excessively expressed and closely correlated in OvCa. Mechanistically, ZEB1 activates the transcription of GLUT3 by binding to its promoter region. Increased expression of GLUT3 driven by ZEB1 dramatically enhances glycolysis, and thus fuels Warburg Effect to promote OvCa progression ...
Source: Biochimica et Biophysica Acta - April 7, 2024 Category: Biochemistry Authors: Furong Lin Lin Ma Shengnan Yu Jing Lin Zhenzhen Xu Hailong Xia Youyi Song Wang Huang Yiling Wu Ying Chen Xiyao Liu Junjie Xia Xiumin Huang Source Type: research

Armed with IL-2 based fusion protein improves CAR-T cell fitness and efficacy against solid tumors
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 5:167159. doi: 10.1016/j.bbadis.2024.167159. Online ahead of print.ABSTRACTChimeric antigen receptor T (CAR-T) cell therapy is regarded as a potent immunotherapy and has made significant success in hematologic malignancies by eliciting antigen-specific immune responses. However, response rates of CAR-T cell therapy against solid tumors with immunosuppressive microenvironments remain limited. Co-engineering strategies are advancing methods to overcome immunosuppressive barriers and enhance antitumor responses. Here, we engineered an IL-2 mutein co-engineered CAR-T for the improve...
Source: Biochimica et Biophysica Acta - April 7, 2024 Category: Biochemistry Authors: Sijin Li Yifei Xia Rui Hou Xu Wang Xuan Zhao Zhangchun Guan Wen Ma Yutong Xu Wei Zhang Dan Liu Junnian Zheng Ming Shi Source Type: research

Bioconcentration potential of ionic liquids: New data on membrane partitioning and its comparison with predictions obtained by COSMOmic
Biochim Biophys Acta Biomembr. 2024 Apr 5:184320. doi: 10.1016/j.bbamem.2024.184320. Online ahead of print.ABSTRACTIonic liquids (ILs) have recently gained significant attention in both the scientific community and industry, but there is a limited understanding of the potential risks they might pose to the environment and human health, including their potential to accumulate in organisms. While membrane and storage lipids have been considered as primary sorption phases driving bioaccumulation, in this study we used an in vitro tool known as solid-supported lipid membranes (SSLMs) to investigate the affinity of ILs to membr...
Source: Biochimica et Biophysica Acta - April 7, 2024 Category: Biochemistry Authors: Jakub Maculewicz Anna Bia łk-Bielińska Dorota Kowalska Piotr Stepnowski Stefan Stolte Stephan Beil Agnieszka Gajewicz-Skretna Joanna Do łżonek Source Type: research

GLUT3 transcriptional activation by ZEB1 fuels the Warburg effect and promotes ovarian cancer progression
This study explores the role of glucose transporter 3 (GLUT3) driven by zinc finger E-box-binding homeobox 1 (ZEB1) in OvCa progression and metastasis. Specifically, this study explored whether ZEB1 promotes glycolysis and assessed the potential involvement of GLUT3 in this process in OvCa cells. Our findings revealed that ZEB1 and GLUT3 were excessively expressed and closely correlated in OvCa. Mechanistically, ZEB1 activates the transcription of GLUT3 by binding to its promoter region. Increased expression of GLUT3 driven by ZEB1 dramatically enhances glycolysis, and thus fuels Warburg Effect to promote OvCa progression ...
Source: Biochimica et Biophysica Acta - April 7, 2024 Category: Biochemistry Authors: Furong Lin Lin Ma Shengnan Yu Jing Lin Zhenzhen Xu Hailong Xia Youyi Song Wang Huang Yiling Wu Ying Chen Xiyao Liu Junjie Xia Xiumin Huang Source Type: research

Armed with IL-2 based fusion protein improves CAR-T cell fitness and efficacy against solid tumors
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 5:167159. doi: 10.1016/j.bbadis.2024.167159. Online ahead of print.ABSTRACTChimeric antigen receptor T (CAR-T) cell therapy is regarded as a potent immunotherapy and has made significant success in hematologic malignancies by eliciting antigen-specific immune responses. However, response rates of CAR-T cell therapy against solid tumors with immunosuppressive microenvironments remain limited. Co-engineering strategies are advancing methods to overcome immunosuppressive barriers and enhance antitumor responses. Here, we engineered an IL-2 mutein co-engineered CAR-T for the improve...
Source: Biochimica et Biophysica Acta - April 7, 2024 Category: Biochemistry Authors: Sijin Li Yifei Xia Rui Hou Xu Wang Xuan Zhao Zhangchun Guan Wen Ma Yutong Xu Wei Zhang Dan Liu Junnian Zheng Ming Shi Source Type: research