Ubiquitin ligase TRIM15 promotes the progression of pancreatic cancer via the upregulation of the IGF2BP2-TLR4 axis

CONCLUSIONS: TRIM15 could ubiquitinate IGF2BP2 to enhance the function of phase separation and the maintenance of mRNA stability of TLR4. TRIM15 is a potential therapeutic target against pancreatic cancer.PMID:38657551 | DOI:10.1016/j.bbadis.2024.167183

Source: Biochimica et Biophysica Acta - April 24, 2024 Category: Biochemistry Authors: Hongkun Cai Jingyuan Zhao Qiyue Zhang Heyu Wu Yan Sun Feng Guo Yingke Zhou Gengdu Qin Wentao Xia Yuhan Zhao Xueyi Liang Shilin Yin Yang Qin Dan Li Heshui Wu Dianyun Ren Source Type: research