Sprayable gel developed by UCLA-led team could help the body fight off cancer after surgery
Many people who are diagnosed with cancer will undergo some type of surgery to treat their disease — almost 95 percent of people with early-diagnosed breast cancer will require surgery and it’s often the first line of treatment for people with brain tumors, for example. But despite improvements in surgical techniques over the past decade, the cancer often comes back after the procedure.Now, a UCLA-led research team has developed a spray gel embedded with immune-boosting drugs that could help. In a peer-reviewed study, the substance was successful half of the time in awakening lab animals ’ immune systems ...
Source: UCLA Newsroom: Health Sciences - December 10, 2018 Category: Universities & Medical Training Source Type: news

Tiny Wearable Device Warns of Exposure to UV Light
Northwestern Medicine and Northwestern’s McCormick School of Engineering scientists have developed what is being called the world’s smallest wearable, battery-free device to measure light. The technology enables scientists to measure exposure to light across multiple wavelengths. The device is as about as thick in diameter as a credit card and is about the size of an M&M. It is also solar powered. Researchers said the device monitored therapeutic UV light in clinical phototherapy booths for psoriasis and atopic dermatitis as well as blue light phototherapy for newborns with jaundice ...
Source: MDDI - December 5, 2018 Category: Medical Devices Authors: Omar Ford Tags: Electronics Source Type: news

Cochrane Library Special Collection: Diagnosing skin cancer
ThisSpecial Collection of Cochrane Systematic Reviews brings together a large body of research on the accuracy of tests used to diagnose skin cancer.The suite of eleven reviews was  led by Dr Jac Dinnes at the University of Birmingham and supported by theCochrane Skin Group and a team of over 30 researchers and expert advisors, funded by the  National Institute for Health Research (NIHR).   The reviews  summarise research evidence assessing the accuracy of different diagnostic tests to support clinical and policy related decision making in the diagnosis of all types of skin cancer. D...
Source: Cochrane News and Events - December 5, 2018 Category: Information Technology Authors: Katie Abbotts Source Type: news

Incidence rate and risk factors for suicide death in patients with skin malignant melanoma: a Surveillance, Epidemiology, and End Results analysis - Yang J, Chen S, Li Y, Wang B, Xin X, Xue X, Pan Z, Lyu J.
The purpose of this study was to use the Surveillance, Epidemiology, and End Results database to identify the incidence rate and risk factors for suicide death in patients with skin malignant melanoma (MM) in the USA. We screened cases of skin MM in the SE... (Source: SafetyLit)
Source: SafetyLit - December 4, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

New drug combination could be more effective against melanoma
(Massachusetts Institute of Technology) A new study from MIT suggests that combining kinase inhibitors with experimental drugs known as ribonucleases could lead to better results. In tests with human cancer cells, the researchers found that the two drugs given together kill cells much more effectively than either drug does on its own. The combination could also help to prevent tumors from developing drug resistance, says Ronald Raines, the Firmenich Professor of Chemistry at MIT. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 3, 2018 Category: International Medicine & Public Health Source Type: news

Adverse events contribute to costs of metastatic melanoma
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - December 1, 2018 Category: Drugs & Pharmacology Source Type: news

Triple combination cancer immunotherapy improves outcomes in preclinical melanoma model
(Medical University of South Carolina) In adoptive cell transfer immunotherapy, T cells able to recognize a tumor are harvested, expanded in the laboratory, and then reintroduced to attack the tumor. However, they often do not persist long enough to finish the job. A triple combination regimen of adoptive T cell transfer, a PIM kinase inhibitor, and a PD1 inhibitor improved T cell persistence and tumor control in a mouse model of melanoma, report Medical University of South Carolina investigators. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 29, 2018 Category: International Medicine & Public Health Source Type: news

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma
Melanomas originating from mucosal surfaces have low mutation burden, genomic instability, and poor prognosis. To identify potential driver genes, we sequenced hundreds of cancer-related genes in 43 human mucosal melanomas, cataloging point mutations, amplifications, and deletions. The SPRED1 gene, which encodes a negative regulator of mitogen-activated protein kinase (MAPK) signaling, was inactivated in 37% of the tumors. Four distinct genotypes were associated with SPRED1 loss. Using a rapid, tissue-specific CRISPR technique to model these genotypes in zebrafish, we found that SPRED1 functions as a tumor suppressor, part...
Source: ScienceNOW - November 29, 2018 Category: Science Authors: Ablain, J., Xu, M., Rothschild, H., Jordan, R. C., Mito, J. K., Daniels, B. H., Bell, C. F., Joseph, N. M., Wu, H., Bastian, B. C., Zon, L. I., Yeh, I. Tags: Genetics, Medicine, Diseases reports Source Type: news

Adding Oncolytic Virus to Immunotherapy for Advanced Melanoma is Found to be Cost Prohibitive (CME/CE)
(MedPage Today) -- Combination treatment does not extend life and has little clinical benefit, cost-analysis finds (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - November 27, 2018 Category: American Health Source Type: news

New study links deficiency of CoQ10 to an increased risk of melanoma metastasis
(Natural News) Melanoma is regarded as one of the most dangerous types of skin cancers. When caught early on, treatment is fairly straightforward — but once this particular cancer spreads to other parts of the body, it becomes hard to treat, and possibly fatal. Experts estimate that over 9,000 lives are lost to melanoma annually,... (Source: NaturalNews.com)
Source: NaturalNews.com - November 27, 2018 Category: Consumer Health News Source Type: news

Peers choose MD Anderson's Gershenwald, Hwu as new AAAS Fellows
(University of Texas M. D. Anderson Cancer Center) Two leaders in the field of melanoma treatment -- a surgeon and an oncologist -- from The University of Texas MD Anderson Cancer Center have been named Fellows of the American Association for the Advancement of Science (AAAS). Election as a Fellow, a tradition that began in 1874, is an honor bestowed upon AAAS members by their peers. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 27, 2018 Category: Cancer & Oncology Source Type: news

Do Targeted Agents Aid Melanoma Immunotherapy?
Guy Ben-Betzalel, MD spoke withCancer Network about the emerging role of targeted BRAF+MEK inhibition in antitumor immunity. (Source: CancerNetwork)
Source: CancerNetwork - November 27, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Researchers advance role of circulating tumor DNA to detect early melanoma growth
(Johns Hopkins Medicine) Researchers at the Johns Hopkins Kimmel Cancer Center say they have added to evidence that measuring and monitoring tumor DNA that naturally circulates in the blood of melanoma patients can not only reliably help reveal the early stages of cancer growth and spread but also uncover new treatment options that tumor genetic analysis alone may not. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 26, 2018 Category: International Medicine & Public Health Source Type: news

Targeting MC1R in metastatic melanoma
(University of Colorado Anschutz Medical Campus) University of Colorado Cancer Center study describes a molecule that seeks out melanoma cells, for imaging and potentially for therapy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - November 26, 2018 Category: Biology Source Type: news

Tanning Bed Use Hikes Second Melanoma Risk
(MedPage Today) -- Median time to diagnosis of second primary melanoma was 225 days (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - November 24, 2018 Category: Dermatology Source Type: news

Medical News Today: Melanoma: Keeping these molecules apart could stop cancer spread
Recent research suggests that stopping the proteins LRP1 and tPA from interacting could form the basis of a treatment to halt metastasis in melanoma. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 21, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Oncolytic Virus Tx for Melanoma Called Too Expensive
(MedPage Today) -- Novel treatment may have clinical benefits but cost is hard to justify (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - November 21, 2018 Category: American Health Source Type: news

I Won a Historic Lawsuit, But May Not Live to Get the Money
Dewayne Anthony Lee Johnson has always just gone by Lee. He lived a modest life for 42 years, and was devastated when he was diagnosed with terminal cancer in 2014. Now 46, as he struggles with his advancing illness, Johnson has found sudden celebrity with a historic victory over one of the world’s most powerful and controversial corporations – Monsanto Co. Johnson sued Monsanto alleging that he developed a deadly form of non-Hodgkin lymphoma after being drenched with the company’s herbicides, which he sprayed as part of his job as school groundskeeper. In Aug. 2018, a jury in San Francisco unanimously f...
Source: TIME: Health - November 21, 2018 Category: Consumer Health News Authors: Carey Gillam Tags: Uncategorized Cancer monsanto Source Type: news

Cutting the legs off cancer
(University of Tokyo) Melanoma skin cancer tumors grow larger and are more likely to metastasize due to interactions between a pair of molecules, according to experiments in mice and human cells. The results may restore the potential for a type of cancer therapy previously abandoned in clinical trials. The results also implicate one molecule already connected to obesity and dementia as a potential cause of metastasis, or spread of cancer cells to other areas of the body. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 20, 2018 Category: Cancer & Oncology Source Type: news

TNM Staging 8th Edition and Its Implications for Skin Cancer TNM Staging 8th Edition and Its Implications for Skin Cancer
This article summarizes important changes in the 8th edition of TNM that impact the staging, risk stratification, and management of melanoma and nonmelanoma skin cancer.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 19, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

MHRA Drug Safety Update: Hydrochlorothiazide: risk of non-melanoma skin cancer particularly in long-term use
The Medicines and Healthcare products Regulatory Agency (MHRA) has issued a drug safety update: Hydrochlorothiazide: risk of non-melanoma skin cancer, particularly in long-term use... (Source: Royal Pharmaceutical Society News)
Source: Royal Pharmaceutical Society News - November 15, 2018 Category: Drugs & Pharmacology Source Type: news

When Melanoma spreads to the brain, patients with BRAF or MEK mutations can find novel treatment
(University of Arizona Health Sciences) Its ample sun puts residents at risk for melanoma, but Arizona is also home to experimental treatments through early-phase clinical trials at the University of Arizona Cancer Center. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 15, 2018 Category: Cancer & Oncology Source Type: news

New Melanoma Treatments Do Not Supplant Surgery as First-Line Therapy New Melanoma Treatments Do Not Supplant Surgery as First-Line Therapy
Although several new melanoma treatments have shown promise, none replaces surgery as the primary therapy yet, according to updated guidelines from the American Academy of Dermatology (AAD).Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - November 13, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

Suicide risk in melanoma: what do we know? - Komic A, Taludker A, Walsh N, Jones A, Lawson A, Bateson B, Kruse EJ.
[Abstract unavailable] Language: en... (Source: SafetyLit)
Source: SafetyLit - November 9, 2018 Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news

New Guidelines for Early-Stage Melanoma Treatment
The American Academy of Dermatology published new clinical practice guidelines with recommendations for the treatment of primary cutaneous melanoma. (Source: CancerNetwork)
Source: CancerNetwork - November 9, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

Yale study shows immunotherapy drug helps patients with metastatic melanoma
New research suggests that melanoma patients with brain metastases should be given a combination of two types of checkpoint inhibitors. (Source: Yale Science and Health News)
Source: Yale Science and Health News - November 8, 2018 Category: Universities & Medical Training Source Type: news

Medical News Today: What to know about nodular melanoma
Nodular melanoma is the most aggressive form of skin cancer. In this article, we look at the symptoms, causes, risk factors, and treatments for nodular melanoma. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 6, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

OncoSec shares fall on preliminary data from skin cancer trial
Shares in OncoSec Medical (NSDQ:ONCS) fell nearly -60% this morning after the company revealed preliminary data from its Phase IIb trial of intratumoral delivery of Tavo in people with unresectable, advanced melanoma. OncoSec’s lead product, Tavo, uses electroporation to deliver IL-12 directly into a patient’s tumor, triggering an immune response. Get the full story at our sister site, Drug Delivery Business News. The post OncoSec shares fall on preliminary data from skin cancer trial appeared first on MassDevice. (Source: Mass Device)
Source: Mass Device - November 6, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Clinical Trials Drug-Device Combinations Oncology Pharmaceuticals Wall Street Beat OncoSec Medical Source Type: news

How melanoma evades targeted therapies
(Thomas Jefferson University) New research shows how metastatic melanoma becomes resistant to a common class of targeted therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 6, 2018 Category: Cancer & Oncology Source Type: news

NCRI: Highlights from the Annual Conference
(MedPage Today) -- Prostate cancer tradeoffs, rising melanoma mortality, safer regimen for thyroid cancer (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - November 6, 2018 Category: Dermatology Source Type: news

Medical News Today: Melanoma: More evidence that antioxidants speed up tumor spread
New research reveals that antioxidants that bind to mitochondria — the main source of free radicals — either have no effect or cause tumors to grow faster. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 5, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Global skin cancer deaths rising for men but not women, study says
Men are dying at a higher rate than women from melanoma, an aggressive form of skin cancer, a new global analysis said. (Source: CNN.com - Health)
Source: CNN.com - Health - November 5, 2018 Category: Consumer Health News Source Type: news

Global skin cancer deaths rising for men but not women
Men are dying at a higher rate than women from melanoma, an aggressive form of skin cancer, a new global analysis said. (Source: CNN.com - Health)
Source: CNN.com - Health - November 5, 2018 Category: Consumer Health News Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 5, 2018 Category: Cancer & Oncology Tags: Dermatology, Family Medicine, Gynecology, Oncology, Reproductive Medicine, Preventive Medicine, News, Source Type: news

Global skin cancer deaths rising for men, but not women, study says
Men are dying at a higher rate than women from melanoma, an aggressive form of skin cancer, a new global analysis said. (Source: CNN.com - Health)
Source: CNN.com - Health - November 5, 2018 Category: Consumer Health News Source Type: news

World Melanoma Deaths Up Among Men, But Not Women
Melanoma death rates were higher for men than for women, according to an analysis of World Health Organization data from 33 countries between 1985 and 2015. (Source: WebMD Health)
Source: WebMD Health - November 5, 2018 Category: Consumer Health News Source Type: news

Skin cancer deaths have soared around the world since the 1980s
Australia has the worst relationship with melanoma - it kills 8.3 people per every 100,000. The UK ranks 15th out of 33 with 4.2 deaths for the same amount of population. (Source: the Mail online | Health)
Source: the Mail online | Health - November 5, 2018 Category: Consumer Health News Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
MONDAY, Nov. 5, 2018 -- Melanoma skin cancer death rates in men are on the rise in most countries, but are stable or declining for women in some, according to a new study. Researchers analyzed World Health Organization data from 33 countries... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - November 5, 2018 Category: General Medicine Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
Title: Global Melanoma Deaths Up Among Men, But Not WomenCategory: Health NewsCreated: 11/5/2018 12:00:00 AMLast Editorial Review: 11/5/2018 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - November 5, 2018 Category: Cancer & Oncology Source Type: news

Team studying rare disorder discovers novel way to target melanoma
(University of North Texas Health Science Center) While studying a rare genetic disorder called NGLY1 deficiency, UNT Health Science Center researchers discovered a new targeted treatment for combating melanoma, a skin cancer that kills about 9,000 people in the United States each year. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 5, 2018 Category: International Medicine & Public Health Source Type: news

Global Melanoma Deaths Up Among Men, But Not Women
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - November 5, 2018 Category: Cancer & Oncology Source Type: news

Melanoma death rates are rising in men but static or falling in women
(National Cancer Research Institute) The rate of men dying from malignant melanoma has risen in populations around the world, while in some countries the rates are steady or falling for women, according to research presented at the 2018 NCRI Cancer Conference. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 4, 2018 Category: Cancer & Oncology Source Type: news

AAD Releases New Guidelines for the Tx of Cutaneous Melanoma
Guidelines recommend surgical excision as primary treatment modality, emphasize individualized care (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - November 1, 2018 Category: Cancer & Oncology Tags: Dermatology, Oncology, Pathology, Pharmacy, Radiology, Surgery, Journal, Source Type: news

AAD Releases New Guidelines for the Tx of Cutaneous Melanoma
THURSDAY, Nov. 1, 2018 -- New guidelines have been released for the treatment of primary cutaneous melanoma, according to a report from the American Academy of Dermatology published online Nov. 1 in the Journal of the American Academy of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 1, 2018 Category: Pharmaceuticals Source Type: news

Fishing for new leads in a rare melanoma
(Boston Children's Hospital) Many cancers arise from a double hit: activation of a tumor-promoting gene plus loss of a tumor suppressor gene. A new study shows that zebrafish, a versatile model for disease research and drug discovery, can help tease out the interplay of genetic alterations in cancer, and could help guide treatment strategies. The study involved mucosal melanomas, a rare, poorly understood and often deadly type of melanoma that affects internal surfaces of the body. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2018 Category: Cancer & Oncology Source Type: news

Specific CD8 T cell states may indicate response to immune checkpoint therapy for melanoma
(Massachusetts General Hospital) A multi-institutional research team, led by investigators at Massachusetts General Hospital and the Broad Institute of MIT and Harvard, has identified specific states of cytotoxic CD8 T cells associated with patient response to checkpoint immunotherapy for melanoma. Their study providing data that could help better understand why checkpoint therapy doesn't work for all patients and may enable development of tests to predict which patients may be helped by the approach. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - November 1, 2018 Category: Cancer & Oncology Source Type: news

Medical News Today: What are the symptoms of skin cancer?
Skin cancer is the most common cancer in the United States. People should check every month for signs of melanoma and other skin cancers. In this article, we take a close look at the types of skin cancer and the symptoms to look for. We also discuss risk factors and prevention. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 29, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

RNA-protein network may explain why melanoma grows more
(Tokyo University of Agriculture and Technology) A collaboration led by scientists from KU Leuven, Belgium, with Tokyo University of Agriculture and Technology (TUAT), Japan, revealed a new way to fight melanoma. They realize that a melanoma-specific long non-coding RNA, named SAMMSON, interacts with the protein CARF, to properly coordinate protein synthesis in both the cytosol and mitochondria of melanoma cells. This mechanism ensures the maintenance of proteostasis during cell growth, thus avoiding the induction of cell death. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 29, 2018 Category: Cancer & Oncology Source Type: news

New data provides guidance for management of moderately dysplastic moles
(Beth Israel Deaconess Medical Center) Study suggests close observation is a reasonable management strategy for moderately dysplastic moles, but certain patients require continued screening for risk for melanoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 26, 2018 Category: International Medicine & Public Health Source Type: news