Does Neoadjuvant pCR in Melanoma Predict Better Outcomes? Does Neoadjuvant pCR in Melanoma Predict Better Outcomes?
Jeffrey Weber discusses recent trials investigating neoadjuvant combination immunotherapy in patients with melanoma.Medscape Oncology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - April 16, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology Commentary Source Type: news

Moffitt researchers identify mechanism of resistance to BRAF inhibitors in melanoma
(H. Lee Moffitt Cancer Center& Research Institute) Melanoma is one of the most aggressive types of skin cancer, but recent advances in targeted therapies have improved the prognosis for many patients. Unfortunately, for some patients these positive outcomes are not long lasting, due to the development of drug resistance and tumor recurrence. Moffitt Cancer Center researchers have discovered a mechanism by which melanoma cells become resistant to the commonly used drugs that target the BRAF protein and its signaling pathway. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 15, 2019 Category: Cancer & Oncology Source Type: news

The Risks of Getting a Tattoo Are Rare, But Real. Here ’s What to Know
Nearly three in 10 Americans have a tattoo, yet ink is still somewhat stigmatized. Many job seekers and office workers hide their body art rather than risk disapproval from higher-ups. Research also finds that tattoo stigma is widespread. A recent study, published in the journal Stigma and Health, found that when hypothetical patients with HIV or lung cancer had tattoos, others were more likely to blame them for their high health care costs compared to tattoo-free folks with the same illnesses. The study provides “initial evidence that tattooed individuals face health disparities,” the study authors write. Ta...
Source: TIME: Health - April 12, 2019 Category: Consumer Health News Authors: Jamie Ducharme Tags: Uncategorized Research Source Type: news

Immunotherapeutics in the Management of Metastatic Melanoma Immunotherapeutics in the Management of Metastatic Melanoma
Advances in immunotherapeutics in the last decade have drastically changed the outlook for patients with metastatic melanoma. Review the currently available immunotherapies in this update.Skin Therapy Letter (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 12, 2019 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

In Melanoma, IO plus HDAC Inhibitor Yields'Impressive Results'In Melanoma, IO plus HDAC Inhibitor Yields'Impressive Results '
Jeffrey Weber comments on a promising approach for heavily pretreated melanoma patients that was recently presented at the 2019 AACR annual meeting.Medscape Oncology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - April 11, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology Commentary Source Type: news

CNIO researchers assess melanoma progression with a new liquid biopsy technique
(Centro Nacional de Investigaciones Oncol ó gicas (CNIO)) Analysis of extracellular vesicles and circulating DNA from fluid obtained from the drainage implanted after surgery, normally disposed of as medical waste, detects melanoma patients with risk of recurrence and may help doctors decide who should undergo adjuvant therapyThe new technique might change the way melanoma patients are followed up.The upcoming goals are to verify whether liquid biopsy can be used to analyze blood directly and to explore its potential use in other tumors. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 11, 2019 Category: International Medicine & Public Health Source Type: news

'Nanobodies' from alpacas could help bring CAR T-cell therapy to solid tumors
(Boston Children's Hospital) Most CAR T-cell therapies look for antigens specific to cancer cells. A new approach described in this week's PNAS instead targets the environment around the tumor, using unusually small antibodies made naturally by alpacas, camels and llamas. Using this approach in mouse models, investigators successfully curbed melanoma and colon cancer - solid tumors that currently can't be treated with CAR T-cell therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 11, 2019 Category: Cancer & Oncology Source Type: news

Cancer: Central role of cell 'skeleton' discovered
(CNRS) All cells possess a cytoskeleton which allows them to move and maintain their shape. However, scientists recently showed that a part of this cytoskeleton called branched actin is also essential to cell proliferation. This mechanism could nevertheless represent a therapeutic target to fight certain types of cancer. Inhibiting the formation of branched actin, for example, prevents the growth of a type of melanoma cells, against which no other specific treatment exists today. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 10, 2019 Category: Cancer & Oncology Source Type: news

More skin cancer screenings means more diagnoses
Melanoma skin cancer cases are expected to increase by 5.7 percent this year, per the American Cancer Society ’s annual statistics report, but doctors have a positive outlook on that growth. Skin cancer is the most common form of cancer in America, with melanoma diagnoses on the rise, reports Allure. In 2018, there were about 91,270 new diagnoses, and 2019 is projected to see 96,480 new cases.  But me lanoma’s death rate dropped each year between 2007 and 2016, according to the annual report,… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - April 8, 2019 Category: Pharmaceuticals Authors: Caitlin Mullen Source Type: news

France Bans Textured Breast Implants
France has banned several types of textured breast implants that have been linked to a rare form of cancer, and more countries appear to be following suit, including Canada and the Netherlands. For years researchers have raised concern about the potential association between breast implants and anaplastic large cell lymphoma (ALCL), a very rare form of cancer, but France is the first country to ban the devices. The ban took effect on Friday and covers macro-textured implants and implants with a polyurethane coating. The National Agency for Safety of Medicines and Health Products (ANSM) in France notified manufa...
Source: MDDI - April 8, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Regulatory and Compliance Source Type: news

Potential Role of the HPV Vaccine in Preventing Non-Melanoma Skin Cancers
The association between the presence of several viruses and non-melanoma skin cancer was investigated in a recent study. (Source: CancerNetwork)
Source: CancerNetwork - April 5, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Entinostat Plus Pembrolizumab Shows Promise in Previously Treated Melanoma
Cancer Network spoke with Ryan J. Sullivan, MD, about the efficacy and safety of entinostat plus pembrolizumab in patients previously treated with immunotherapy. (Source: CancerNetwork)
Source: CancerNetwork - April 4, 2019 Category: Cancer & Oncology Authors: Ryan J. Sullivan, MD Source Type: news

CheckMate 204:'Practice-Changing' for Metastatic Melanoma CheckMate 204:'Practice-Changing' for Metastatic Melanoma
The ipilimumab plus nivolumab combination gives patients a reasonable chance of CNS tumor regression, thus not requiring radiation, according to Jeffrey Weber.Medscape Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - April 3, 2019 Category: Consumer Health News Tags: Hematology-Oncology Commentary Source Type: news

Medical News Today: Gut microbes can spur immune system to attack cancer
An international study has identified gut bacteria that activate the immune system to slow melanoma growth in mice and highlights a key signaling pathway. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - April 2, 2019 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Is your melanoma hot enough for immunotherapy?
(University of Colorado Anschutz Medical Campus) University of Colorado Cancer Center study presented at AACR 2019 shows that tumors with mutations in genes leading to over-activation of the NF-kB signaling pathway were more than three times as likely to respond to anti-PD1 immunotherapy compared with tumors in which these changes were absent. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 2, 2019 Category: Cancer & Oncology Source Type: news

OncoSec Announces Advanced Therapy Medicinal Product Classification from the EMA for TAVO(TM) in Refractory Metastatic Melanoma
Classification as an ATMP Positions TAVO for Accelerated Review and Approval in Europe SAN DIEGO and PENNINGTON, N.J., April 1, 2019 -- (Healthcare Sales & Marketing Network) -- OncoSec Medical Incorporated (OncoSec) (NASDAQ: ONCS), a company developin... Biopharmaceuticals, Oncology, Regulatory OncoSec Medical, TAVO , metastatic melanoma (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - April 1, 2019 Category: Pharmaceuticals Source Type: news

HDAC inhibition may combat resistance to anti-PD-1 therapy in patients with melanoma
(American Association for Cancer Research) A combination of the experimental histone deacetylase (HDAC) inhibitor entinostat with the anti-PD-1 therapeutic pembrolizumab (Keytruda) showed clinical responses in patients with melanoma that had progressed on prior anti-PD-1 treatment, according to results from the ENCORE 601 phase Ib/II clinical trial presented at the AACR Annual Meeting 2019, March 29-April 3. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - April 1, 2019 Category: Cancer & Oncology Source Type: news

Living With Cancer: Melanoma can begin in the eye
Eye melanoma? Melanoma is a type of cancer that develops in the cells that produce melanin -- the pigment that gives your skin its color. Your eyes also have melanin-producing cells and can develop melanoma. Eye melanoma, also called ocular melanoma, most often forms in the part of the eye you can't see when looking [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - March 29, 2019 Category: Databases & Libraries Source Type: news

Heating up tumors could make CAR T therapy more effective, study finds
UCLAZhen GuFINDINGSA preclinical study led by scientists at theUCLA Jonsson Comprehensive Cancer Center suggests that heating solid tumors during CAR T-cell therapy can enhance the treatment ’s success.The researchers found that when a heating technique called photothermal ablation was combined with the infusion of CAR T cells, it suppressed melanoma tumor growth for up to 20 days in mice. Among the mice that were treated with the combination, 33 percent were still tumor free after the 20-day mark.BACKGROUNDT cells that have been genetically engineered with chimeric antigen receptor, or CAR, have successfully been us...
Source: UCLA Newsroom: Health Sciences - March 27, 2019 Category: Universities & Medical Training Source Type: news

MD Anderson study may explain why immunotherapy not effective for some patients with metastatic melanoma and kidney cancer
(University of Texas M. D. Anderson Cancer Center) White blood cells known as B cells have been shown to be effective for predicting which cancer patients will respond to immune checkpoint blockade (ICB) therapy, according to a study at The University of Texas MD Anderson Cancer Center. Study results will be presented April 2 at the AACR Annual Meeting 2019 in Atlanta. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 25, 2019 Category: International Medicine & Public Health Source Type: news

BU researchers discover therapeutic target of melanoma
(Boston University School of Medicine) Researchers have identified a biomarker and a possible new therapy for melanoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 25, 2019 Category: International Medicine & Public Health Source Type: news

' Optimistic' Longer-term Outcomes for Metastatic Melanoma'Optimistic' Longer-term Outcomes for Metastatic Melanoma
Targeted therapy and immunotherapy are showing promising longer-term outcomes in metastatic melanoma. Dr Weber reviews two new studies.Medscape Oncology (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - March 21, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology Commentary Source Type: news

No Elevated Cancer Risk for RA Patients With Tocilizumab (CME/CE)
(MedPage Today) -- Combined risk for new cancers except non-melanoma skin cancer with IL-6r inhibitor not significantly different than with TNF inhibitors (Source: MedPage Today Hematology/Oncology)
Source: MedPage Today Hematology/Oncology - March 20, 2019 Category: Hematology Source Type: news

FDA Busts J & amp;J and Sientra Over Breast Implant Compliance
FDA busted two manufacturers of silicone gel-filled breast implants this week for failure to comply with post-approval study requirements. The agency sent warning letters to Irvine, CA-based Mentor Worldwide, a unit of Johnson & Johnson, and to Santa Barbara, CA-based Sientra for deficiencies in each company's post-approval study for silicone breast implant approvals. Breast implants have been a source of contention between patient advocacy groups, industry, and FDA for decades. Implants were banned from the U.S. market from 1992 to 2006, and the devices have been the cause of an ove...
Source: MDDI - March 20, 2019 Category: Medical Devices Authors: Amanda Pedersen Tags: Regulatory and Compliance Source Type: news

Direct targeting of G{alpha}q and G{alpha}11 oncoproteins in cancer cells
Somatic gain-of-function mutations of GNAQ and GNA11, which encode α subunits of heterotrimeric Gαq/11 proteins, occur in about 85% of cases of uveal melanoma (UM), the most common cancer of the adult eye. Molecular therapies to directly target these oncoproteins are lacking, and current treatment options rely on radiation, surgery, or inhibition of effector molecules downstream of these G proteins. A hallmark feature of oncogenic Gαq/11 proteins is their reduced intrinsic rate of hydrolysis of guanosine triphosphate (GTP), which results in their accumulation in the GTP-bound, active state. Here, we repor...
Source: Signal Transduction Knowledge Environment - March 19, 2019 Category: Science Authors: Annala, S., Feng, X., Shridhar, N., Eryilmaz, F., Patt, J., Yang, J., Pfeil, E. M., Cervantes-Villagrana, R. D., Inoue, A., Häberlein, F., Slodczyk, T., Reher, R., Kehraus, S., Monteleone, S., Schrage, R., Heycke, N., Rick, U., Engel, S., Pfeifer, Tags: STKE Research Articles Source Type: news

Misdiagnosed Malignant Tumor on an Ischemic Limb Misdiagnosed Malignant Tumor on an Ischemic Limb
Read about this case in which acral lentiginous melanoma was initially diagnosed as a vascular ulcer.Wounds (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 18, 2019 Category: Consumer Health News Tags: General Surgery Journal Article Source Type: news

Fewer T1 Melanoma Nodal Biopsies After 2009 Staging Manual Fewer T1 Melanoma Nodal Biopsies After 2009 Staging Manual
The overall number of T1 melanomas undergoing nodal biopsy have decreased following the 7th edition of the AJCC Cancer Staging Manual (AJCC 7), according to a new study.Reuters Health Information (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - March 17, 2019 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Medical News Today: Laser probe detects deadly melanoma in seconds
A Ph.D. student has designed a cost-effective and easy-to-use device that can quickly detect cancerous skin cells. Catching cancer earlier can save lives. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 16, 2019 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Skin cancer signs: Seven symptoms of the potentially deadly disease revealed by a doctor
SKIN cancer is caused by ultraviolet light damaging the DNA in skin cells. What ’s commonly not known is there are two types of skin cancer - melanoma skin cancer and non-melanoma skin cancer. A doctor has revealed seven symptoms to look out for. (Source: Daily Express - Health)
Source: Daily Express - Health - March 15, 2019 Category: Consumer Health News Source Type: news

2 new PET tracers may best FDG in cancer imaging
Cancer detection could receive a boost from two new radiotracers that have...Read more on AuntMinnie.comRelated Reading: Later PET/CT follow-up helps for oropharyngeal cancer Ga-68 PSMA-11 PET/MRI improves prostate cancer detection New PET tracer could aid melanoma detection FDG-PET/CT fails for peripheral T-cell lymphoma outcomes PET/CT predicts success of rad therapy for spinal mets (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 14, 2019 Category: Radiology Source Type: news

Medical News Today: Marine bacteria offer new weapon against melanoma
Melanoma is notoriously difficult to treat. Recently, scientists have looked to marine bacteria to find novel ways of attacking this type of skin cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 14, 2019 Category: Consumer Health News Tags: Cancer / Oncology Source Type: news

Singapore firm, Stanford team up on AI for liver cancer
Genomic medicine company Lucence Diagnostics has launched a joint effort with...Read more on AuntMinnie.comRelated Reading: Stanford launches huge dataset of chest x-rays for AI New PET tracer could aid melanoma detection AI could bring ultralow-dose imaging to amyloid PET AI may help in fight against gadolinium deposition Machine learning can predict stroke treatment outcomes (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 12, 2019 Category: Radiology Source Type: news

Evidence on Nicotinamide for High-Risk Non-Melanoma Skin Cancers
A review published in  Experimental Dermatology examined the safety and efficacy of nicotinamide in reducing non-melanoma skin cancers. (Source: CancerNetwork)
Source: CancerNetwork - March 12, 2019 Category: Cancer & Oncology Authors: Naveed Saleh, MD, MS Source Type: news

Later PET/CT follow-up helps for oropharyngeal cancer
Using PET/CT for follow-up at a later interval than what's recommended by existing...Read more on AuntMinnie.comRelated Reading: FDG-PET/CT aids in melanoma treatment assessment CT lung screening can catch recurring head, neck cancer ASTRO: Blood test confirms HPV-related cancer remission FDG-PET/CT fails for peripheral T-cell lymphoma outcomes FDG-PET/CT helps stage men with breast cancer, too (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 11, 2019 Category: Radiology Source Type: news

FDG-PET/CT aids in melanoma treatment assessment
Researchers have developed a new FDG-PET/CT-based approach to better monitor...Read more on AuntMinnie.comRelated Reading: New PET tracer could aid melanoma detection FDG-PET/CT fails for peripheral T-cell lymphoma outcomes PET/CT predicts success of rad therapy for spinal mets FDG-PET/CT helps stage men with breast cancer, too PET/CT makes case for directing cervical cancer treatment (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - March 7, 2019 Category: Radiology Source Type: news

A New Dosing Regimen for Nivolumab Plus Ipilimumab in Advanced Melanoma
The  CheckMate 511 phase IIIb/IV trial investigated raising the nivolumab dose to 3 mg/kg and lowering the ipilimumab dose to 1 mg/kg. (Source: CancerNetwork)
Source: CancerNetwork - March 7, 2019 Category: Cancer & Oncology Authors: Christina Bennett, MS Source Type: news

Labour MP Chris Bryant fights through tears while discussing his cancer battle on live TV
Chris Bryant, the MP for Rhondda in Wales, revealed on Sky News today he felt 'cold' and convinced he would die when told he had stage three melanoma skin cancer on his scalp. (Source: the Mail online | Health)
Source: the Mail online | Health - March 6, 2019 Category: Consumer Health News Source Type: news

Seawater bacteria provides leads to fight melanoma
(American Chemical Society) Malignant melanoma can be a particularly dangerous form of cancer, and more therapeutic options are needed. Now, researchers report in ACS Medicinal Chemistry Letters that a bacteria from seawater has inspired promising leads for an entirely new way to treat the disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 6, 2019 Category: International Medicine & Public Health Source Type: news

Low-cost 'cancer probe' could spot deadly melanoma early
(University of British Columbia) Work is being done at UBC on a tool to help in the early detection of melanoma: a simple, compact laser probe that can distinguish between harmless moles and cancerous ones -- in a matter of seconds. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 6, 2019 Category: Biology Source Type: news

Early Response to PD-1 Blockade Predicts Melanoma Outcomes Early Response to PD-1 Blockade Predicts Melanoma Outcomes
The response to a single dose of neoadjuvant PD-1 blockade predicts clinical outcomes in patients with stage III/IV resectable melanoma, researchers report.Reuters Health Information (Source: Medscape Allergy Headlines)
Source: Medscape Allergy Headlines - March 5, 2019 Category: Allergy & Immunology Tags: Hematology-Oncology News Source Type: news

Nuclear medicine imaging monitors effectiveness of therapy for melanoma patients
(Society of Nuclear Medicine and Molecular Imaging) Nuclear medicine imaging with PET/CT can monitor the effectiveness of immunotherapy treatment for metastatic melanoma and predict outcome. In this way, a patient's therapy can be more effectively tailored to his or her personal response. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - March 5, 2019 Category: Cancer & Oncology Source Type: news

Diet Could Influence Immunotherapy Response Via Microbiome Diet Could Influence Immunotherapy Response Via Microbiome
In melanoma patients, diet may influence the response to immunotherapy with checkpoint inhibitors via an action on a patient's gut microbiome.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - March 4, 2019 Category: Gastroenterology Tags: Hematology-Oncology News Source Type: news

Genomic testing of a single patient reveals a gene commonly mutated in pediatric melanoma
(St. Jude Children's Research Hospital) Comprehensive clinical genomic testing of an adolescent patient, including whole genome sequencing, helped researchers identify mutations in a single gene that drive the most common childhood melanoma. The St. Jude Children's Research Hospital study appears as an advance online publication today in the journal Nature Medicine.Further research found that 33 percent of young people with spitzoid melanoma screened in this study carried novel mutations, including rearrangements, in the same gene, MAP3K8. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 4, 2019 Category: International Medicine & Public Health Source Type: news

Medical News Today: New compound could fight off aggressive melanoma
New research examines the genetic chain reaction that causes a particularly aggressive form of melanoma and finds a way to stop it. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - March 1, 2019 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

High-Fiber Diet May Help Gut 'Microbiome' Battle Melanoma
Title: High-Fiber Diet May Help Gut 'Microbiome' Battle MelanomaCategory: Health NewsCreated: 2/27/2019 12:00:00 AMLast Editorial Review: 2/28/2019 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - February 28, 2019 Category: Cancer & Oncology Source Type: news

High-Fiber Diet May Help Gut 'Microbiome' Battle Melanoma
(Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - February 28, 2019 Category: Cancer & Oncology Source Type: news

High - Fiber Diet May Help Gut ‘ Microbiome ’ Battle Melanoma
(Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - February 28, 2019 Category: Cancer & Oncology Tags: Nursing, Oncology, Pharmacy, Alternative Medicine, Nutrition, News, Source Type: news

Neoadjuvant Anti-PD-1 Predicts Melanoma Outcomes
(MedPage Today) -- One-dose immune response tied to 63% DFS and 93% OS at 2 years (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - February 27, 2019 Category: Dermatology Source Type: news

High-Fiber Diet May Help Your Gut Battle Melanoma
New research suggests that a diet that's full of fiber appears to lead to more diverse intestinal bacteria (microbiome). In turn, a thriving gut microbiome is linked to a stronger response to an immune therapy for the aggressive skin cancer. (Source: WebMD Health)
Source: WebMD Health - February 27, 2019 Category: Consumer Health News Source Type: news

High-Fiber Diet May Help Gut'Microbiome' Battle Melanoma
WEDNESDAY, Feb. 27, 2019 -- A healthy diet may trigger a better response to a certain kind of melanoma treatment. How? New research suggests that a diet that's full of fiber appears to lead to more diverse intestinal bacteria (microbiome). In... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - February 27, 2019 Category: General Medicine Source Type: news