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President ’s Letter Summer ‘17
This article takes the participatory medicine concept a bit further to include some of the socioeconomic factors and other, non-medical actors (data companies, vendors, health plans, etc.) and has received very positive reaction. Note: If you have published an article or spoken at an event this year, please let me know.  I would like to showcase these in next month’s newsletter. IT Assistance:  In moving to Connect, our new communications platform, there was a need for certain IT coding to automate processes and build efficiencies.  SPM member Anatoly Postilnik volunteered the services of his developme...
Source: Society for Participatory Medicine - August 18, 2017 Category: General Medicine Authors: Nanette Mattox Tags: Newsletter Exec Committee participatory medicine Presidents Letter Source Type: news

Periodontal Disease Linked to Certain Cancer Types
In this interview we discuss a recent study that linked periodontal disease with an increased cancer risk, specifically melanoma and cancers of the lung, breast, esophagus, and gallbladder. (Source: CancerNetwork)
Source: CancerNetwork - August 18, 2017 Category: Cancer & Oncology Authors: Jean Wactawski-Wende, PhD Source Type: news

Skin cancer warning: THIS marker of beauty could be an unlikely sign of deadly melanoma
SKIN cancer rates are on the rise due to an increase in unprotected sun exposure. For one type - lentigo maligna melanoma - freckles on the face could be a sign. (Source: Daily Express - Health)
Source: Daily Express - Health - August 18, 2017 Category: Consumer Health News Source Type: news

Two-step process leads to cell immortalization and cancer
(University of California - Berkeley) Immortalization of cells is a necessary step in the development of cancer, and scientists think that the main cause is turning on an enzyme -- telomerase -- that lengthens chromosomal telomeres and prevents normal cell death. A new study by UC Berkeley scientists shows that turning on telomerase is not a one-step process. In melanoma, and probably other cancers, a mutation turns up telomerase slightly, keeping the cell alive long enough for other changes that up-regulate telomerase. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 17, 2017 Category: International Medicine & Public Health Source Type: news

Melanoma leaves women with huge open wound on her forehead
Bethany Gambardella-Greenway, 39, was diagnosed with stage 3-A melanoma 18 months after a misdiagnose from her dermatologist. The Texas mother-of-two is left with a scar on her head. (Source: the Mail online | Health)
Source: the Mail online | Health - August 16, 2017 Category: Consumer Health News Source Type: news

Age of Patients With Thin Melanomas a Consideration in SLNB Recommendations
Age may be an important factor in estimating lymph node positivity in thin melanoma, according to the results of a recent study. (Source: CancerNetwork)
Source: CancerNetwork - August 16, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Melanoma News Source Type: news

Proposed: Trial of Vitamin Derivative to Prevent Melanoma Proposed: Trial of Vitamin Derivative to Prevent Melanoma
The vitamin B3 derivative nicotinamide was previously shown to reduce nonmelanoma skin cancers in a phase 3 trial.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 16, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Changing Treatment Paradigms for Brain Metastases From Melanoma —Part 1: Diagnosis, Prognosis, Symptom Control, and Local Treatment
Much work has been done recently to try to determine the optimal therapies for brain metastases in melanoma patients, the most effective ways to combine them, and ideal radiation dose and fractions. (Source: CancerNetwork)
Source: CancerNetwork - August 15, 2017 Category: Cancer & Oncology Authors: Manmeet S. Ahluwalia, MD, FACP Pauline Funchain, MD Rupesh Kotecha, MD Samuel T. Chao, MD Vyshak Alva Venur, MD Tags: Melanoma Oncology Journal Review Article Source Type: news

Cancer treatment: sorting the good news from the hype
The newspapers love a cancer research story, but many are misleading or won ’t affect patients for many years. But there is plenty of progress worth reportingEvery news story about cancer research should come with a health warning: believe the hope, but not the hype. Good headlines are quick and catchy, good science is steady steps taken on a complicated issue over a long time. If a new treatment is still being researched, it could be metaphorical miles and actual years away from getting into the hands or bodies of patients. Asblogger Kay Curtin, who has advanced melanoma, puts it: “The media tend to pick ...
Source: Guardian Unlimited Science - August 14, 2017 Category: Science Authors: Naomi Elster Tags: Cancer research Health & wellbeing Life and style Society Medical research Science Source Type: news

Melanoma and Parkinson's: A Surprising Connection Melanoma and Parkinson's: A Surprising Connection
Dr Arefa Cassoobhoy highlights one of the week's important news stories for primary care.Medscape Internal Medicine (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 11, 2017 Category: Consumer Health News Tags: Internal Medicine Commentary Source Type: news

The Four Ws of Skin Cancer Surveillance in Melanoma Patients The Four Ws of Skin Cancer Surveillance in Melanoma Patients
Why, Who, When, and Where? The author of this commentary explores these questions surrounding the need for a personalized follow-up regimen for patients with melanoma.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 10, 2017 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Medical News Today: Could vitamin B-3 help to prevent melanoma?
A new review suggests that nicotinamide - a form of vitamin B-3 - could be a promising candidate for the prevention of melanoma, the deadliest skin cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - August 9, 2017 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Researchers look to improve detection of skin cancer lacking pigment melanin
(UNC Lineberger Comprehensive Cancer Center) UNC Lineberger scientists were part of a multi-institution research team that identifed key features linked to amelanotic melanoma, a form of skin cancer that lacks the brown or black color that stems from the pigment melanin. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 9, 2017 Category: Cancer & Oncology Source Type: news

Vitamin therapy may help prevent melanoma
(Wiley) A new review highlights the potential of nicotinamide (vitamin B3) for preventing melanoma in high-risk individuals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 9, 2017 Category: International Medicine & Public Health Source Type: news

Personalized melanoma genomic risk triggers family conversations
(Wiley) A new study published in the British Journal of Dermatology indicates that personalized melanoma genomic risk information can prompt discussions about skin cancer prevention and skin examinations with family and health professionals. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 9, 2017 Category: International Medicine & Public Health Source Type: news

Melanoma and Wrong-Site Surgery
(MedPage Today) -- More patient involvement is one way to prevent this major error (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - August 8, 2017 Category: Dermatology Source Type: news

Alcohol linked to an increased risk of skin cancer
Conclusion These findings should be interpreted with care before concluding that an alcoholic drink per day increases your risk of skin cancer. There are several important cautions: These are only observational studies. It wouldn't be possible to randomise people to different alcohol intake and follow them to look at cancer development. And with observational studies, many other health, sociodemographic and lifestyle factors may be influencing the link between alcohol intake and cancer development. The studies differed considerably in terms of the influencing factors they took account of, with some adjusting for various ...
Source: NHS News Feed - August 7, 2017 Category: Consumer Health News Tags: Cancer Source Type: news

Pembrolizumab Plus Reduced Ipilimumab Dose Active in Advanced Melanoma
Standard-dose pembrolizumab with four reduced doses of ipilimumab followed by standard-dose pembrolizumab had a manageable safety profile and antitumor activity in patients with advanced melanoma. (Source: CancerNetwork)
Source: CancerNetwork - August 7, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Melanoma News Source Type: news

Young men who died of melanoma remembered with free sunscreen project in city parks
The memories of two young men who died of the most deadly form of skin cancer are living on in a new pilot project adding free sunscreen dispensers to five local parks. (Source: CBC | Health)
Source: CBC | Health - August 5, 2017 Category: Consumer Health News Tags: News/Canada/Toronto Source Type: news

Gum Disease Tied to Cancer Risk in Older Women
Periodontal disease was associated with an increased risk of esophageal and gallbladder cancers, cancers of the breast and lung, and melanoma. (Source: NYT Health)
Source: NYT Health - August 2, 2017 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Smoking and Tobacco Teeth and Dentistry Gums (Mouth) Cancer Gallbladder Melanomas Source Type: news

Periodontal Disease History Linked to Increased Cancer Risk
For older women, risk of total cancer, melanoma, and breast, lung, esophagus, gallbladder cancers up (Source: Pulmonary Medicine News - Doctors Lounge)
Source: Pulmonary Medicine News - Doctors Lounge - August 2, 2017 Category: Respiratory Medicine Tags: Dermatology, Family Medicine, Geriatrics, Gastroenterology, Gynecology, Internal Medicine, Nursing, Oncology, Pathology, Pulmonology, Radiology, Surgery, Journal, Source Type: news

Duxbury Mom Battling Cancer Challenges Others To Help Her Live Longer
Duxbury (CBS) – Lindsay McGrath knows she’s in the fight of her life. “I literally dropped to my knees when I got the call from my doctor and said this can’t happen to me,” Lindsay said. Just six weeks after her son was born this 36 year-old mother of three children has been diagnosed with a rare form of cancer called ocular melanoma. A cancer of the eye which is now spread to her liver, spine and ribs. “Among the cancers this is probably, unfortunately, one of the more deadly ones. People should get their eyes dilated because a lot of people have freckles on the back of their eyes, but ...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - July 31, 2017 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Local News Syndicated Local Jump For Lindsay Lindsay McGrath Melanoma Paul Burton Source Type: news

Intel Gained on Melanoma Risk for Renal Transplant Patients
Age - standardized relative rate of melanoma 4.9 in U.S. Renal Data System versus SEER patients (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 28, 2017 Category: Cancer & Oncology Tags: Dermatology, Internal Medicine, Nephrology, Nursing, Oncology, Surgery, Journal, Source Type: news

Medical News Today: Melanoma: New, more effective drug steps closer
Scientists have designed and tested a new compound that they think will succeed where current drugs against melanoma have failed. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 28, 2017 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Melanoma isn't the only serious skin cancer
A type of skin cancer called squamous cell carcinoma (SCC) is increasingly common in the United States. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 28, 2017 Category: Consumer Health News Source Type: news

Colorado man had 98 tumors removed from his brain
Leland Fay, a 46-year-old from Monument, Colorado, had 98 tumors removed from his brain. He was diagnosed with melanoma in 2011 and it quickly spread to his lungs, stomach and brain. (Source: the Mail online | Health)
Source: the Mail online | Health - July 28, 2017 Category: Consumer Health News Source Type: news

Melanoma Isn't the Only Serious Skin Cancer
Squamous cell carcinoma is far more common and also dangerous if untreated, dermatologist says (Source: Cancercompass News: Other Cancer)
Source: Cancercompass News: Other Cancer - July 28, 2017 Category: Cancer & Oncology Source Type: news

Could eating broccoli be a cure for melanoma?
Scientists have devised a compound that slows melanoma tumour growth  by 69%. It is based on naturally occurring, anti-cancer isothiocyanates found in the 'cabbage family'. (Source: the Mail online | Health)
Source: the Mail online | Health - July 27, 2017 Category: Consumer Health News Source Type: news

Melanoma Isn't the Only Serious Skin Cancer
Squamous cell carcinoma is far more common and also dangerous if untreated, dermatologist says (Source: WebMD Health)
Source: WebMD Health - July 27, 2017 Category: Consumer Health News Source Type: news

Melanoma Isn ’ t the Only Serious Skin Cancer
Squamous cell carcinoma is far more common and also dangerous if untreated, dermatologist says (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - July 27, 2017 Category: Cancer & Oncology Tags: Dermatology, Oncology, News, Source Type: news

Melanoma Isn't the Only Serious Skin Cancer
THURSDAY, July 27, 2017 -- A type of skin cancer called squamous cell carcinoma (SCC) is increasingly common in the United States, so people need to be alert for signs of the disease, an expert says. About 700,000 new cases of this skin cancer are... (Source: Drugs.com - Daily MedNews)
Source: Drugs.com - Daily MedNews - July 27, 2017 Category: General Medicine Source Type: news

Melanoma Isn't the Only Serious Skin Cancer
Title: Melanoma Isn't the Only Serious Skin CancerCategory: Health NewsCreated: 7/27/2017 12:00:00 AMLast Editorial Review: 7/27/2017 12:00:00 AM (Source: MedicineNet Cancer General)
Source: MedicineNet Cancer General - July 27, 2017 Category: Cancer & Oncology Source Type: news

Neon Therapeutics and Apexigen start Phase IIb combination trial for melanoma
Immuno-oncology firm Neon Therapeutics has partnered with biopharmaceutical company Apexigen to investigate its NEO-PV-01 in combination with APX005M in a Phase IIb trial to treat patients with metastatic melanoma. (Source: Drug Development Technology)
Source: Drug Development Technology - July 26, 2017 Category: Pharmaceuticals Source Type: news

Skin cancer breakthrough: Scientists discover way to treat DEADLIEST type
SKIN CANCER is diagnosed in 100,000 people a year, with 2,500 cases proving fatal annually. However, researchers may have discovered how to kill melanoma cancer cells. (Source: Daily Express - Health)
Source: Daily Express - Health - July 26, 2017 Category: Consumer Health News Source Type: news

Compound shows promise in treating melanoma
(Penn State) While past attempts to treat melanoma failed to meet expectations, an international team of researchers are hopeful that a compound they tested on both mice and on human cells in a petri dish takes a positive step toward creating a drug that can kill melanoma cancer cells without harming nearby healthy cells. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 26, 2017 Category: International Medicine & Public Health Source Type: news

Belfast medical students asked to wear 'skin cancer tattoos'
The Queen's University study aims to give medical students an insight into living with melanoma. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - July 25, 2017 Category: Consumer Health News Source Type: news

FDA Approves Ipilimumab for Pediatric Melanoma
The FDA has expanded the approval of ipilimumab (Yervoy) to include the treatment of pediatric melanoma patients 12 years and older with unresectable or metastatic disease. (Source: CancerNetwork)
Source: CancerNetwork - July 25, 2017 Category: Cancer & Oncology Authors: Ian Ingram Tags: Melanoma News Pediatric Cancers Source Type: news

Shedding light on cause of resistance to tumor immunotherapy
(University of Zurich) In tumor immunotherapy, the body's own defense system is activated against the tumor cells. However, for the majority of patients, the tumor cells become resistant to the treatments used. Researchers at the University of Zurich and the University Hospital Zurich have now found in skin cutaneous melanoma that an epigenetic control protein is key to the development of this resistance. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 25, 2017 Category: Cancer & Oncology Source Type: news

U.S. Food and Drug Administration expands approval of Yervoy ® (ipilimumab) to include pediatric patients 12 years and older with unresectable or metastatic melanoma
Bristol-Myers Squibb Company (NYSE:BMY) today announced that the U.S. Food and Drug Administration (FDA) has expanded the indication for Yervoy ® (ipilimumab) injection for intravenous use to now include the treatment of unresectable or metastatic melanoma in pediatric patients 12 years of age and older. (Source: World Pharma News)
Source: World Pharma News - July 24, 2017 Category: Pharmaceuticals Tags: Featured Bristol-Myers Squibb Business and Industry Source Type: news

FDA Expands Approval of Yervoy (ipilimumab) to Include Pediatric Patients 12 Years and Older with Unresectable or Metastatic Melanoma
PRINCETON, N.J.--(BUSINESS WIRE) July 24, 2017 --Bristol-Myers Squibb Company (NYSE:BMY) today announced that the U.S. Food and Drug Administration (FDA) has expanded the indication for Yervoy (ipilimumab) injection for intravenous use to now... (Source: Drugs.com - New Drug Approvals)
Source: Drugs.com - New Drug Approvals - July 24, 2017 Category: Drugs & Pharmacology Source Type: news

Georgia State's Inlighta Biosciences gets $2 million grant to develop enhanced MRI contrast agents
(Georgia State University) A local start-up, life sciences company founded by Dr. Jenny Yang, Regents' Professor of Biochemistry at Georgia State University, has received a $2 million federal grant to develop improved magnetic resonance imaging (MRI) contrast agents for the early detection of liver cancers and other cancers, such as uveal melanoma or eye cancer, that have metastasized to the liver. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 24, 2017 Category: International Medicine & Public Health Source Type: news

Younger Age Predicts Node Positivity in T1 Melanoma (CME/CE)
(MedPage Today) -- Positive nodes twice as likely in patients under 40 (Source: MedPage Today State Required CME)
Source: MedPage Today State Required CME - July 20, 2017 Category: Consumer Health News Source Type: news

Number of T-cells predicts response to immunotherapy in melanoma
Researchers at the University of California, San Francisco found the number of immune cells in tumors may predict the efficacy of immunotherapy against melanoma. (Source: Health News - UPI.com)
Source: Health News - UPI.com - July 20, 2017 Category: Consumer Health News Source Type: news

University of Sussex to carry out vital skin cancer research thanks to new grant
(University of Sussex) The Spencer Lab has been awarded a £ 428K grant to research a protein present in high amounts in melanoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 20, 2017 Category: International Medicine & Public Health Source Type: news

Immune-cell numbers predict response to combination immunotherapy in melanoma
(University of California - San Francisco) Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study conducted by UC San Francisco researchers joined by physicians from UCSF Health. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 20, 2017 Category: Cancer & Oncology Source Type: news

Melanoma, Parkinson's: See One, Be Aware of the Other Melanoma, Parkinson's: See One, Be Aware of the Other
A new study confirms that these two diseases may be risk factors for one another.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 19, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

John McCain's skull surgery explained
Senator John McCain's Friday afternoon surgery in Arizona could be a sign of something much more serious when considering his medical history and bouts of melanoma. (Source: the Mail online | Health)
Source: the Mail online | Health - July 18, 2017 Category: Consumer Health News Source Type: news

Medical News Today: Daily tomato consumption may protect against skin cancer
Consuming tomatoes daily may help to protect skin against UV light damage and decrease the likelihood of developing skin cancer tumors, new research finds. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - July 17, 2017 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Austin mother mistook her skin cancer for hormonal changes
Bethany Greenway, 39, from Austin, Texas, is celebrating having beat desmoplastic melanoma - an aggressive, and rare, form of skin cancer. (Source: the Mail online | Health)
Source: the Mail online | Health - July 17, 2017 Category: Consumer Health News Source Type: news

CheckMate 037: Nivolumab Improved Responses, Not Survival in Advanced Melanoma
Patients with advanced melanoma treated with nivolumab had higher and more durable responses compared with investigator ’s choice of chemotherapy, but these increases did not result in improved survival outcomes. (Source: CancerNetwork)
Source: CancerNetwork - July 17, 2017 Category: Cancer & Oncology Authors: Leah Lawrence Tags: Melanoma News Source Type: news