Machine-learning driven findings uncover new cellular players in tumor microenvironment
(CytoReason) New findings presented today by CytoReason reveals possible new cellular players in the tumor microenvironment that could impact the treatment process for the most in-need patients -- those who have already failed to respond to ipilimumab (anti-CTLA4) immunotherapy. Once validated, the findings could point the way to improved strategies for the staging and ordering of key immunotherapies in refractory melanoma. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 16, 2018 Category: International Medicine & Public Health Source Type: news

Nivolumab vs Ipilimumab in Treatment of Advanced Melanoma Nivolumab vs Ipilimumab in Treatment of Advanced Melanoma
A new study compares nivolumab in combination with ipilimumab or nivolumab vs. ipilimumab monotherapy for extending overall or progression-free survival in adults with advanced melanoma.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 15, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

Dual Neoadjuvant Checkpoint Blockade Feasible in Melanoma
(MedPage Today) -- Good survival outcomes, but high rates of toxicities, with ipilimumab-nivolumab combo (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - October 12, 2018 Category: Dermatology Source Type: news

Do siblings lower your cancer risk? People with big families are less likely to develop the disease
The larger the family, the less frequently certain types of cancer occur, including brain, bladder, lung, stomach, breast, ovarian colorectal and cervical cancers as well as melanoma. (Source: the Mail online | Health)
Source: the Mail online | Health - October 11, 2018 Category: Consumer Health News Source Type: news

Study: Atypical Moles Not Precursors to Melanoma
(MedPage Today) -- But data show they are markers of risk for cutaneous melanoma arising elsewhere (Source: MedPage Today Dermatology)
Source: MedPage Today Dermatology - October 10, 2018 Category: Dermatology Source Type: news

Melanoma | Medscape Melanoma | Medscape
Review in-depth clinical information, latest medical news, and guidelines on melanoma skin cancer and metastatic melanoma. Understand how to identify signs of malignant melanomas. (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 10, 2018 Category: Consumer Health News Tags: Resource Center Source Type: news

Hereditary melanoma effectively treated with immunotherapy
Individuals with an inherited form of melanoma responded well to immunotherapy in a small trial in Sweden. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 9, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Existing antibiotic could help treat melanoma
Drug resistance is a significant problem when treating melanoma. A new study concludes that an old antibiotic might offer new hope. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 8, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Neoadjuvant combination checkpoint blockade trial yields high response rates for patients with high-risk stage three melanoma
(University of Texas M. D. Anderson Cancer Center) Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage three melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 8, 2018 Category: International Medicine & Public Health Source Type: news

Immunotherapy effective against hereditary melanoma
(Karolinska Institutet) Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year's Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, research from Karolinska Institutet in Sweden shows. The study is published in the Journal of Medical Genetics. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 8, 2018 Category: Cancer & Oncology Source Type: news

Pediatric Melanoma More Common in Melanoma-Prone Families
The percentage of patients with pediatric melanoma is 6-fold to the 28-fold higher when compared with the general population of patients with melanoma. (Source: CancerNetwork)
Source: CancerNetwork - October 5, 2018 Category: Cancer & Oncology Authors: Leah Lawrence Source Type: news

BRAF-MEK Inhibitor Combo Extends Survival in BRAF-Mutant Melanoma
The combination of encorafenib and binimetinib resulted in longer overall survival compared with vemurafenib in patients with BRAF V600 –mutant melanoma. (Source: CancerNetwork)
Source: CancerNetwork - October 4, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

How Scientists Are Treating Breast Cancer Using the Immune System
As a pharmacist, Kathy James considers herself well educated about the importance of getting regular cancer screenings. Even though the 55-year-old had no history of cancer in her family, she never skipped her regular mammograms, and she gave herself regular breast exams. So she was dumbfounded when, during one of those self-exams in May 2017, she felt a marble-size lump in her left breast. A visit to the doctor confirmed it. “The radiologist came in with his hands in his pockets and looked down and said, ‘It doesn’t look good,'” James says. After a biopsy, James and her husband learned she had meta...
Source: TIME: Health - October 4, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized breast cancer news Frontiers of Medicine Source Type: news

How Scientists Are Treating Breast Cancer Using the Immune System
As a pharmacist, Kathy James considers herself well educated about the importance of getting regular cancer screenings. Even though the 55-year-old had no history of cancer in her family, she never skipped her regular mammograms, and she gave herself regular breast exams. So she was dumbfounded when, during one of those self-exams in May 2017, she felt a marble-size lump in her left breast. A visit to the doctor confirmed it. “The radiologist came in with his hands in his pockets and looked down and said, ‘It doesn’t look good,'” James says. After a biopsy, James and her husband learned she had meta...
Source: TIME: Science - October 4, 2018 Category: Science Authors: Alice Park Tags: Uncategorized breast cancer news Frontiers of Medicine Source Type: news

Scientists find old antibiotic may selectively kill dangerous skin cancer cells
(Medical Research Council) An old antibiotic, called nifuroxazide, could selectively kill dangerous cells within melanomas -- the deadliest type of skin cancer -- scientists from the MRC Institute of Genetics and Molecular Medicine at the University of Edinburgh have found. The study, published in the journal Cell Chemical Biology, found the drug showed promise for complementing existing melanoma therapies. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 4, 2018 Category: Cancer & Oncology Source Type: news

PET/CT predicts success of rad therapy for spinal mets
FDG-PET/CT scans can predict the success of radiation therapy in patients with...Read more on AuntMinnie.comRelated Reading: FDG-PET/CT helps stage men with breast cancer, too FES-PET enhances treatment for metastatic breast cancer Can deep learning monitor lesions on F-18 NaF PET/CT? CMS again declines coverage for NaF-PET scans Extremity PET/CT scans unnecessary for melanoma patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - October 3, 2018 Category: Radiology Source Type: news

New Cancer Treatments Just Won Two Scientists a Nobel Prize. Here ’s How They Work
It wasn’t the Nobel Committee that reached James Allison first on Monday to inform him that he had won the coveted annual prize in Physiology or Medicine. It was his son who broke the news with a 5:30 am phone call. Minutes later, a Swedish reporter reached him before the committee could. “I was like, ‘Oh my God, it happened,’” Allison says to TIME. “I’m just in shock, I guess.” Allison, chair of immunology at the University of Texas MD Anderson Cancer Center, was awarded the Nobel for his discovery in 1994 in mice that led to an entirely new class of anti-cancer drugs called...
Source: TIME: Health - October 1, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Cancer healthytime Source Type: news

New Cancer Treatments Just Won 2 Scientists a Nobel Prize. Here ’s How They Work
It wasn’t the Nobel Committee that reached James Allison first on Monday to inform him that he had won the coveted annual prize in Physiology or Medicine. It was his son who broke the news with a 5:30 am phone call. Minutes later, a Swedish reporter reached him before the committee could. “I was like, ‘Oh my God, it happened,’” Allison says to TIME. “I’m just in shock, I guess.” Allison, chair of immunology at the University of Texas MD Anderson Cancer Center, was awarded the Nobel for his discovery in 1994 in mice that led to an entirely new class of anti-cancer drugs called...
Source: TIME: Health - October 1, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Cancer healthytime Source Type: news

Novel Immunotherapy May Up Survival in Melanoma Brain Mets
Findings in patients receiving checkpoint blockade immunotherapy for melanoma brain metastases (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - September 25, 2018 Category: Cancer & Oncology Tags: Dermatology, Neurology, Oncology, Pharmacy, Journal, Source Type: news

Prognostic Value of Low Tumor Burden in Patients With Melanoma
In this article, we review the role of baseline tumor size in response and survival on traditional and contemporary therapies for the treatment of locoregional and distant melanoma recurrences. (Source: CancerNetwork)
Source: CancerNetwork - September 19, 2018 Category: Cancer & Oncology Authors: Andrew S. Poklepovic, MD, Richard D. Carvajal, MD Source Type: news

Breast Implant Study Should Be Taken with a Grain of Salt, FDA Says
A study linking silicone gel-filled breast implants with several rare diseases should be viewed with caution, according to FDA. The authors of the study, published last week in the Annals of Surgery, say they looked at data from nearly 100,000 breast implant procedures gleaned from FDA-mandated postmarket studies for implants made by Johnson & Johnson's Mentor business, and by Allergan. The analysis showed that silicone implants are associated with higher rates of  Sjögren syndrome, scleroderma, rheumatoid arthritis, stillbirth, and melanoma. The researchers reported that 56% of the...
Source: MDDI - September 18, 2018 Category: Medical Devices Authors: Amanda Pedersen Tags: Implants Source Type: news

FDA pushes back on silicone breast implant study
The FDA last week pushed back at a large study showing an association between silicone breast implants and some rare diseases, standing by its record of warning the public about their risks – despite granting approvals to a slew of the implants in recent years. The study, published Sept. 14 in the Annals of Surgery, looked at data from nearly 100,000 breast implant procedures the researchers gleaned from FDA-mandated post-approval studies for implants made by Johnson & Johnson (NYSE:JNJ) unit Mentor and by Allergan (NYSE: AGN). The analysis showed that silicone implants are associated with higher rates of Sj...
Source: Mass Device - September 17, 2018 Category: Medical Devices Authors: Brad Perriello Tags: Featured Food & Drug Administration (FDA) Women's Health Allergan johnsonandjohnson Source Type: news

Targeted treatment for melanoma to be free on NHS
Trials showed the risk of the cancer returning after surgery was reduced with the therapy. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - September 17, 2018 Category: Consumer Health News Source Type: news

A Multistep Algorithm to Detect In Situ Melanomas A Multistep Algorithm to Detect In Situ Melanomas
The authors present a multistep diagnostic algorithm for in situ melanoma detection using reflectance confocal microscopy combined with dermoscopy.The British Journal of Dermatology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 17, 2018 Category: Consumer Health News Tags: Dermatology Journal Article Source Type: news

NICE approves new treatment for high-risk skin cancer
Combined drug to target mutation-positive melanoma Related items fromOnMedica Is crowdfunding for cancer patients paying for ‘quackery’? Cancer patients using complementary meds die sooner Prediction tool to help develop better cancer drugs Counsel young people to avoid skin cancer, says US Prescribe higher dose opioids for shorter time after surgery (Source: OnMedica Latest News)
Source: OnMedica Latest News - September 17, 2018 Category: UK Health Source Type: news

Another reason to garden? Scientists discover a microbe in dirt that fights melanoma
(Natural News) Tending to a garden is known to lower stress levels in city dwellers, and is also known to provide mental health wellness for people who find it difficult to cope with life. An Oregon State University study found that a soil-dwelling bacterium helps kill cancerous melanoma cells – one more reason to take up that... (Source: NaturalNews.com)
Source: NaturalNews.com - September 15, 2018 Category: Consumer Health News Source Type: news

Global Estimates Belittle Burden of Skin Diseases Global Estimates Belittle Burden of Skin Diseases
A patient-driven project is underway to accurately measure skin diseases around the world so that melanoma and psoriasis are not rated as being less problematic than gout.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 15, 2018 Category: Consumer Health News Tags: Dermatology News Source Type: news

PET/CT makes case for directing cervical cancer treatment
Can FDG-PET/CT be used to direct the treatment of locally advanced cervical...Read more on AuntMinnie.comRelated Reading: Extremity PET/CT scans unnecessary for melanoma patients FDG-PET/CT could improve treatment for NSCLC patients ASTRO: PET predicts outcomes in vulvar cancer patients (Source: AuntMinnie.com Headlines)
Source: AuntMinnie.com Headlines - September 14, 2018 Category: Radiology Source Type: news

Study: Individualized treatment would reduce melanoma cells
Individualized treatment for melanoma would reduce the number of cancer cells, based on a study in lab dishes and animals. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 12, 2018 Category: Consumer Health News Source Type: news

Cancer vaccine hope as scientists cure skin melanoma in 100% of mice
Researchers at the Scripps Research Institute and the University of Texas injected mice with an immunotherapy drug and a chemical called Diprovocim, which made the jab more effective. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2018 Category: Consumer Health News Source Type: news

Hope for a cancer vaccine as scientists cure skin melanoma in 100% of mice in a trial
Researchers at the Scripps Research Institute and the University of Texas injected mice with an immunotherapy drug and a chemical called Diprovocim, which made the jab more effective. (Source: the Mail online | Health)
Source: the Mail online | Health - September 12, 2018 Category: Consumer Health News Source Type: news

Medical News Today: Skin cancer: Common IBD, arthritis drug may raise risk
A new study finds a link between a drug used widely to treat inflammatory bowel disease, arthritis, and vasculitis and a common form of skin cancer. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 12, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Shedding light on 100-year-old cancer mystery
(Sanford Burnham Prebys Medical Discovery Institute) Using genetic and pharmacological means, scientists at Sanford Burnham Prebys Medical Discovery Institute (SBP) were surprised to find that blocking LDHA had only a limited impact on melanoma cells, since they were able to redirect energy production. Their results identify an alternative growth pathway driven by a molecule called ATF4, revealing new potential targets for drug development. The study was published today in EMBO Journal. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 12, 2018 Category: Biology Source Type: news

Toward an 'ultra-personalized' therapy for melanoma
(Weizmann Institute of Science) With new immunotherapy treatments for melanoma, recovery rates have risen dramatically, in some cases to around 50 percent. But they could be much higher: A new study led by researchers at the Weizmann Institute of Science showed, in lab dishes and animal studies, that a highly personalized approach could help the immune cells improve their abilities to recognize the cancer and kill it. The results of this study were published today in Cancer Discovery. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 12, 2018 Category: Cancer & Oncology Source Type: news

Skin cancer warning: How to tell if your mole is cancerous - Dr Chris reveals
SKIN cancer symptoms usually include a new mole, or a change to an existing mole. But how can you actually tell if you should see a doctor over malignant melanoma fears? This Morning ’s Dr Chris Steele reveals what signs and symptoms to look out for. (Source: Daily Express - Health)
Source: Daily Express - Health - September 11, 2018 Category: Consumer Health News Source Type: news

9/11 Cancer Deaths Continue to Rise
John Feal believes more people will die from illnesses related to 9/11 than from the terrorist attack at the World Trade Center. He should know. He’s a first responder who witnesses it every day. And he is not alone in his belief. Feal, a longtime advocate for Sept. 11 survivors and those dying from diseases related to the terrorist attacks, will again host the annual naming ceremony at the 9/11 Responders Remembered Park in Smithtown, Long Island. Each year he reads the names of those who have died within the past year. And each year, the list is longer than the last. On the 17th anniversary of the terrorist attack...
Source: Asbestos and Mesothelioma News - September 10, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

Medical News Today: New cancer vaccine is 100 percent successful in mouse model
A team of experts has conducted tests in mice for a potent new vaccine against melanoma. So far, the researchers have observed a 100 percent success rate. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - September 10, 2018 Category: Consumer Health News Tags: Melanoma / Skin Cancer Source Type: news

Updates in Pharmacotherapy for Melanoma Updates in Pharmacotherapy for Melanoma
This article reviews the latest new and emerging systemic therapies for advanced melanoma, including immunotherapy and targeted therapy.U.S. Pharmacist (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 7, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

TGen-led canine melanoma study identifies genetic basis of disease; potential drug targets
(The Translational Genomics Research Institute) TGen and its collaborators from across the nation used multiple genomic analysis techniques to identify several gene mutations that could be the keys to what drives melanoma in dogs. Following the path from human melanoma, the findings of recurring molecular changes in canine melanoma can help veterinary physicians pinpoint potential new treatments for dogs. Likewise, human physicians will view these changes in light of the type of melanoma that occurs in non-sun exposed areas in the mouth, or other mucosal surfaces. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 7, 2018 Category: Cancer & Oncology Source Type: news

Scientists test new cancer vaccine against melanoma
(Scripps Research Institute) The findings suggest these vaccines could increase chances of recovery in cases where a drug therapy alone is not working. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 6, 2018 Category: International Medicine & Public Health Source Type: news

Minimal functional driver gene heterogeneity among untreated metastases
Metastases are responsible for the majority of cancer-related deaths. Although genomic heterogeneity within primary tumors is associated with relapse, heterogeneity among treatment-naïve metastases has not been comprehensively assessed. We analyzed sequencing data for 76 untreated metastases from 20 patients and inferred cancer phylogenies for breast, colorectal, endometrial, gastric, lung, melanoma, pancreatic, and prostate cancers. We found that within individual patients, a large majority of driver gene mutations are common to all metastases. Further analysis revealed that the driver gene mutations that were not share...
Source: ScienceNOW - September 6, 2018 Category: Science Authors: Reiter, J. G., Makohon-Moore, A. P., Gerold, J. M., Heyde, A., Attiyeh, M. A., Kohutek, Z. A., Tokheim, C. J., Brown, A., DeBlasio, R. M., Niyazov, J., Zucker, A., Karchin, R., Kinzler, K. W., Iacobuzio-Donahue, C. A., Vogelstein, B., Nowak, M. A. Tags: Medicine, Diseases reports Source Type: news

Mayo Clinic physicians receive Stand up to Cancer Catalyst Award for melanoma research
This study, ?Neoactivate?, will test two novel approaches to the treatment of patients with high-risk, stage 3 melanoma guided by specific mutations within [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - September 6, 2018 Category: Hospital Management Source Type: news

Could Adding a TLR9 Agonist Improve Responses in Metastatic Melanoma?
The combination of pembrolizumab and a TLR9 agonist known as SD-101 showed promising activity in patients with unresectable or metastatic melanoma. (Source: CancerNetwork)
Source: CancerNetwork - September 5, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Researchers find unexpected planetary dependence in 1-10 percent of melanoma diagnoses
(World Scientific) In a paper to be published in the September 2018 issue of Biophysical Reviews and Letters, researchers have discovered that there is a correlation and possible cause and effect between otherwise invisible dark matter particles and melanoma, a type of skin cancer. This opens the door to more research in the interdisciplinary fields of physics and medicine. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 5, 2018 Category: Cancer & Oncology Source Type: news

Scientists identify weak point in deadly eye melanoma
(Washington University School of Medicine) A natural plant compound exploits a newly identified Achilles' heel in a cancer of the eye, uveal melanoma. In human cancer cells growing in the lab, the compound shuts down the overactive signaling that drives uveal melanoma cell growth, according to researchers at Washington University School of Medicine in St. Louis. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - September 5, 2018 Category: Cancer & Oncology Source Type: news

Targeting nucleotide exchange to inhibit constitutively active G protein {alpha} subunits in cancer cells
Constitutively active G protein α subunits cause cancer, cholera, Sturge-Weber syndrome, and other disorders. Therapeutic intervention by targeted inhibition of constitutively active Gα subunits in these disorders has yet to be achieved. We found that constitutively active Gαq in uveal melanoma (UM) cells was inhibited by the cyclic depsipeptide FR900359 (FR). FR allosterically inhibited guanosine diphosphate–for–guanosine triphosphate (GDP/GTP) exchange to trap constitutively active Gαq in inactive, GDP-bound Gαβ heterotrimers. Allosteric inhibition of other Gα subunits...
Source: Signal Transduction Knowledge Environment - September 4, 2018 Category: Science Authors: Onken, M. D., Makepeace, C. M., Kaltenbronn, K. M., Kanai, S. M., Todd, T. D., Wang, S., Broekelmann, T. J., Rao, P. K., Cooper, J. A., Blumer, K. J. Tags: STKE Research Articles Source Type: news

Could Active Surveillance Help Prevent Advanced Melanoma in CLL Patients?
Active surveillance could help lead to early excision of melanoma, and thus better outcomes, in patients with CLL. (Source: CancerNetwork)
Source: CancerNetwork - August 29, 2018 Category: Cancer & Oncology Authors: Dave Levitan Source Type: news

Investigating treatment resistance in cancer
(University of Erlangen-Nuremberg) Melanoma and liver cancer are among the types of cancer which are most likely to be fatal in the Western world. Researchers at Friedrich-Alexander-Universit ä t Erlangen-N ü rnberg have discovered a mechanism used to steer the growth of the cancer cells in both types of cancer, a discovery which is significant for future treatment strategies. The researchers' work has been recognized with an award from the Deutsche Leberstiftung for a groundbreaking publication in the field of liver research. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 29, 2018 Category: Cancer & Oncology Source Type: news

TGen-led study of metastatic melanoma secures $2 million grant
(The Translational Genomics Research Institute) Like a medical marathon, physicians run to keep up with metastatic cancer as it races ahead, outsmarting one treatment after another, and this is especially true for patients with metastatic melanoma. Now, some of the nation's top biomedical institutes -- led by the Translational Genomics Research Institute, an affiliate of City of Hope -- have received a $2 million federal grant towards discovering a new way to detect and track metastatic melanoma and understand how it escapes treatment. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - August 29, 2018 Category: Cancer & Oncology Source Type: news