Trial Adds Gemcitabine to Pleural Mesothelioma HIOC Therapy
Results of a phase I clinical trial highlight how the addition of a drug to an existing treatment option appears safe and may improve outcomes in certain patients with malignant pleural mesothelioma (MPM). The primary goal of the trial was to determine the maximum tolerated dose of gemcitabine added to cisplatin when these drugs are delivered together as heated intraoperative chemotherapy (HIOC) during surgery. Researchers have studied cisplatin alone for HIOC. The addition of gemcitabine — a chemotherapy drug often used to treat pancreatic, ovarian and breast cancers — is new. The Journal of Thoracic Oncology...
Source: Asbestos and Mesothelioma News - July 18, 2018 Category: Environmental Health Authors: Matt Mauney Source Type: news

Breath tests may allow for earlier detection of pancreatic cancer
(Wiley) Pancreatic cancer carries a very poor prognosis as most patients are diagnosed at an advanced stage. Now a new BJS (British Journal of Surgery) study indicates that breath analyses may help detect pancreatic cancer earlier, when curative treatments may be possible. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 18, 2018 Category: International Medicine & Public Health Source Type: news

RenovoRx sets its sights on localized treatment of pancreatic cancer
People living with pancreatic cancer find themselves facing devastating odds – the five-year survival rate is in the single digits, according to the American Cancer Rate. Pursuing treatment often means dealing with the side effects of systemic chemotherapy, including hair loss, fatigue and neuropathy. Shaun Bagai and his team at RenovoRx think that their catheter could help usher in a targeted treatment option for these patients. The company’s RenovoCath dual-balloon infusion catheter is designed to localize the delivery of chemotherapy to a pancreatic tumor, eliminating the need for systemic chemothe...
Source: Mass Device - July 13, 2018 Category: Medical Devices Authors: Sarah Faulkner Tags: Catheters Clinical Trials Drug-Device Combinations Food & Drug Administration (FDA) Oncology Pharmaceuticals RenovoRx Source Type: news

Working night shifts drives up the risk of cancer, stroke and heart disease:
A new study from the University of Washington and the University of Surrey has found that working night shift disrupts the peripheral clocks found in your body's tissues such as the liver and pancreas. (Source: the Mail online | Health)
Source: the Mail online | Health - July 10, 2018 Category: Consumer Health News Source Type: news

Reflex Testing for Germline Mutations in Pancreatic Cancer Reflex Testing for Germline Mutations in Pancreatic Cancer
Ancestries are important when considering reflex founder mutation testing in patients with pancreatic cancer.JCO Precision Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 9, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Working night shifts drives up the risk of cancer, stroke and heart disease:
A new study from the University of Washington and the University of Surrey has found that working night shift disrupts the peripheral clocks found in your body's tissues such as the liver and pancreas. (Source: the Mail online | Health)
Source: the Mail online | Health - July 9, 2018 Category: Consumer Health News Source Type: news

Pancreatic cancer: Mutable cancer cells are more dangerous
(Technical University of Munich (TUM)) Pancreatic cancer often spreads, forming metastases in the liver or lungs. The prognosis is better for patients with metastases in the lungs. However, the organ that is more likely to be affected depends on the cancer cells' ability to alter their characteristics and shape -- as a research team at the Technical University of Munich (TUM) has discovered. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 9, 2018 Category: Cancer & Oncology Source Type: news

WSU study reveals how shift work disrupts metabolism
(Washington State University) A new study conducted at Washington State University has brought scientists closer to finding out why working night shifts increases your risk of developing diabetes and other metabolic disorders. The study revealed that just three days of being on a night shift schedule will disrupt metabolism. This disruption appears to be driven by separate biological clocks (so-called peripheral oscillators) in the liver, gut and pancreas, rather than the brain's master clock. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 9, 2018 Category: Cancer & Oncology Source Type: news

Calcium channel blockers, a popular type of blood pressure medicine, shown to raise the risk of pancreatic cancer in menopausal women
(Natural News) Modern medicine involves a lot of trial-and-error. Whatever benefits patients receive from a pharmaceutical is heavily shadowed by the various risks and side effects that typically accompany the drug. Such is the case for a particular type of blood pressure medicine and its apparent link to cancer. A new study carried out by... (Source: NaturalNews.com)
Source: NaturalNews.com - July 8, 2018 Category: Consumer Health News Source Type: news

Science Saturday: Research News Roundup-June 2018
This article includes brief summaries and links to news releases from the preceding month that discuss some of our latest medical research. It also connects readers to related resources.?By Elizabeth Zimmermann ___________________________________________________ This month's Roundup includes a number of findings related to pancreatic cancer and other?gastrointestinal [...] (Source: News from Mayo Clinic)
Source: News from Mayo Clinic - July 7, 2018 Category: Databases & Libraries Source Type: news

Survival in Pancreatic Cancer With Germline Mutations Survival in Pancreatic Cancer With Germline Mutations
Platinum-based therapy may improve survival in pancreatic ductal adenocarcinoma carrying deleterious germline mutations.JCO Precision Oncology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 6, 2018 Category: Consumer Health News Tags: Hematology-Oncology Journal Article Source Type: news

Model Gauges Risk for Pancreatic Cancer at Onset of Diabetes Model Gauges Risk for Pancreatic Cancer at Onset of Diabetes
A risk-stratification score identifies which patients with new-onset diabetes are at high risk of having pancreatic cancer and should receive a clinical workup.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - July 6, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Splice Variant of MUC4 Promotes Pancreatic Cancer Progression
When MUC4/X-overexpressing pancreatic cancer cells were transplanted into mice, tumors grew aggressively, with significant metastasis to liver and peritoneum. (Source: CancerNetwork)
Source: CancerNetwork - July 6, 2018 Category: Cancer & Oncology Authors: Bryant Furlow Source Type: news

Pancreatic cancer symptoms: Three changes in your stools to look out for
PANCREATIC cancer doesn ’t usually cause symptoms in the early stages, which can make it difficult to diagnose. But if signs do show it can have an effect on your bowel habits. There are three changes in your stools you should look out for. (Source: Daily Express - Health)
Source: Daily Express - Health - July 4, 2018 Category: Consumer Health News Source Type: news

UGR makes a step towards earlier diagnosis of pancreatic cancer
(University of Granada) A multidisciplinary team from the University of Granada has developed software that can make it easier to identify potential pancreatic cancer biomarkers and thereby achieve earlier diagnosis. Pancreatic cancer can be diagnosed using biomarkers which are differentially expressed genes indicative of this illness. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2018 Category: Cancer & Oncology Source Type: news

What the satellites in your body do
(Salk Institute) Salk scientists studying satellite RNAs discovered that a specific type called hSATa induces breast cancer by directly interfering with DNA copying and damage repair. The research, which appeared in the journal Molecular Cell on June 7, 2018, suggests that targeting satellite RNAs could provide another approach for treating multiple types of cancer, including breast, ovarian, prostate and pancreatic. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - July 2, 2018 Category: Cancer & Oncology Source Type: news

Hospital at Home; Polio and Brain Cancer: It's PodMed Double T! (with audio)
(MedPage Today) -- This week's topics include hospital at home, using a virus to treat brain cancer, updated osteoporosis guidelines, and an artificial pancreas in hospitalized patients (Source: MedPage Today Nephrology)
Source: MedPage Today Nephrology - June 30, 2018 Category: Urology & Nephrology Source Type: news

Study could make pancreatic cancer treatments more personalized
A new study published this week in Immunity could change the way oncologists tailor treatments to a patient's specific type of tumor. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 29, 2018 Category: Consumer Health News Source Type: news

Penn study reveals secrets of 'hot' and 'cold' pancreatic cancer tumors
(University of Pennsylvania School of Medicine) So-called 'hot' tumors filled with T cells are often considered to be more sensitive to immunotherapy compared to 'cold' tumors with fewer T cells, but a clear demonstration of why has eluded cancer biologists -- until now. A team has discovered that whether a tumor is hot or cold is determined by information embedded in the cancer cells themselves. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2018 Category: International Medicine & Public Health Source Type: news

Atlantic Health System enrolling patients in pancreatic cancer clinical trials
(Tartaglia Communications) Atlantic Health System is now enrolling patients in four pancreatic cancer clinical trials. Angela Alistar, M.D., a nationally known expert on pancreatic cancer, is serving as national Principal Investigator (PI) on the first trial and as local PI on three other trials. In addition, Dr. Alistar will serve as a national and local PI on three additional clinical studies open to enrollment later this year. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2018 Category: International Medicine & Public Health Source Type: news

Polio Virus Could Help Treat Brain Cancer. Here ’s How
The idea that viruses may be co-opted to do good rather than harm isn’t entirely new; researchers have been attempting to harness the power of viruses and bacteria for more than a century. Vaccines are the shining example of using bad bugs to do good in priming the immune system to fight disease. But disease-causing viruses aren’t always easy to corral, and attempts to use them to activate the immune system against things other than fellow bacteria and viruses — including cancer, for example — have not been so successful. There is only one approved virus-based treatment for cancer, which uses herpes...
Source: TIME: Health - June 26, 2018 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Cancer healthytime Source Type: news

Merrimack halts pancreatic cancer trial
Merrimack Pharmaceuticals announced it will discontinue the development of an experimental treatment for pancreatic cancer after the drug failed to meet the main and secondary goals of a mid-stage trial. (Source: PharmaManufacturing.com)
Source: PharmaManufacturing.com - June 25, 2018 Category: Pharmaceuticals Source Type: news

Merrimack to scrap development of pancreatic cancer treatment
(Reuters) - Merrimack Pharmaceuticals Inc said on Monday it would stop developing its experimental treatment for pancreatic cancer after it failed to meet the main and secondary goals in a mid-stage trial. (Source: Reuters: Health)
Source: Reuters: Health - June 25, 2018 Category: Consumer Health News Tags: healthNews Source Type: news

Pancreatic cancer symptoms: Back pain could indicate the condition
PANCREATIC cancer symptoms and signs are caused by changes in the pancreas. Cells start to divide abnormally and uncontrollably, possibly forming a tumour. Watch out for these warning signs of the cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - June 25, 2018 Category: Consumer Health News Source Type: news

Pancreatic cancer symptoms: Back pain could be a sign of the condition
PANCREATIC cancer symptoms and signs are caused by changes in the pancreas. Cells start to divide abnormally and uncontrollably, possibly forming a tumour. Watch out for these warning signs of the cancer. (Source: Daily Express - Health)
Source: Daily Express - Health - June 25, 2018 Category: Consumer Health News Source Type: news

Novel nuclear medicine approach shows promise for treating wide array of cancerous tumors
(Society of Nuclear Medicine and Molecular Imaging) A novel nuclear medicine approach is showing great promise for precision treatment of solid tumors in many types of cancer--including lung, breast, pancreas and ovarian in adults and glioma, neuroblastoma and sarcoma in children. The research was presented today at the SNMMI 2018 Annual Meeting, June 23-26 in Philadelphia. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 25, 2018 Category: Cancer & Oncology Source Type: news

Mother with pancreatic cancer meets lawmakers on Capitol Hill with plea for more research funding
Camille Moses, 58, is one of the nine percent of all people who survive past five years after a pancreatic cancer diagnosis. Now she is begging for more funding for research. (Source: the Mail online | Health)
Source: the Mail online | Health - June 22, 2018 Category: Consumer Health News Source Type: news

WATCH: Survivors of pancreatic cancer bring their fight to Capitol Hill
Members of the Pancreatic Cancer Action Network are lobbying for more research in Washington, D.C. (Source: ABC News: Health)
Source: ABC News: Health - June 21, 2018 Category: Consumer Health News Tags: US Source Type: news

Caris Life Sciences Presents Data Demonstrating the Ability of ADAPT Biotargeting System to Identify Responders and Non-Responders in a Phase III Pancreatic Cancer Study
Leveraging ADAPT Biotargeting System would have significantly increased the probability of success Data presented at the ESMO World Congress on Gastrointestinal Cancer 2018 IRVING, Texas, June 21, 2018 -- (Healthcare Sales & Marketing Network) -- Ca... Diagnostics, Oncology Caris Life Sciences, ADAPT Biotargeting System, precision medicine (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 21, 2018 Category: Pharmaceuticals Source Type: news

Genetic Testing in Relatives of Pancreatic Cancer Patients? Genetic Testing in Relatives of Pancreatic Cancer Patients?
Genetic testing guidelines in pancreatic cancer are urgently needed for patients with pancreatic cancer and their worried relatives.Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - June 21, 2018 Category: Pathology Tags: Hematology-Oncology News Source Type: news

Monitoring is Key in Precipio ’s Liquid Biopsy Success
The liquid biopsy market has expanded greatly in the past few years. From billion-dollar financings to highly publicized spinouts – the space has managed to attract quite a bit of attention and change the dynamic of diagnostics. Earlier this week, Roche made a big play in the space by acquiring the remaining shares of Foundation Medicine for $2.4 billion. Precipio is hoping to make its own impact in liquid biopsy and said it is focused on the monitoring segment of the market. The New Haven, CT-based company is about a year removed from merging with Transgenomics. The transaction also helped Precipio become a public c...
Source: MDDI - June 20, 2018 Category: Medical Devices Authors: Omar Ford Tags: IVD Testing Source Type: news

Five-year survival rate for most common pancreatic cancer just 3%
The “outrageous” five‐year survival rate in England for patients with the most common type of pancreatic cancer ‐ pancreatic ductal adenocarcinoma (PDAC) ‐ has been revealed for the first time in a study, commissioned by the charity Pancreatic Cancer UK (Source: Nursing Times)
Source: Nursing Times - June 20, 2018 Category: Nursing Source Type: news

Researchers identify method to diagnose cancer in patients with early onset diabetes
(Mayo Clinic) Patients diagnosed with pancreatic cancer can develop elevated blood sugar levels up to three years before their cancer diagnosis, according to the results of a study by Mayo Clinic researchers published the journal Gastroenterology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 20, 2018 Category: Cancer & Oncology Source Type: news

Biologists discover how pancreatic tumors lead to weight loss
(Massachusetts Institute of Technology) A study from MIT and Dana-Farber Cancer Institute offers insight into the weight loss seen in pancreatic cancer patients, and suggests that weight loss may not necessarily affect patients' survival. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 20, 2018 Category: Cancer & Oncology Source Type: news

Higher OS With Neoadjuvant Chemo-RT in Pancreatic Cancer
In PREOPANC, the 2-year survival rate was significantly higher for patients who received neoadjuvant chemoradiotherapy vs standard care. (Source: CancerNetwork)
Source: CancerNetwork - June 20, 2018 Category: Cancer & Oncology Authors: Cancer Network Editors Source Type: news

Mayo researchers identify method to diagnose pancreatic cancer in patients with early onset diabetes
ROCHESTER, Minn. ? Patients diagnosed with pancreatic cancer can develop elevated blood sugar levels up to three years before their cancer diagnosis, according to the results of a study by Mayo Clinic researchers published the journal Gastroenterology. ?Pancreatic cancer is rapidly fatal after its diagnosis, with average survival of six months,? says Suresh Chari, M.D., [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - June 20, 2018 Category: Hospital Management Source Type: news

Pancreatic cancer survivor: "No one else should be told go home and die"
"The first doctor who saw me told me to go home and die," says a pancreatic cancer survivor who hopes one day no one else will have to hear those words (Source: Health News: CBSNews.com)
Source: Health News: CBSNews.com - June 19, 2018 Category: Consumer Health News Source Type: news

Recent - Onset Diabetes Tied to Increased Pancreatic Cancer Risk
Latinos, African - Americans with recent - onset disease have higher risk than those with long - term disease (Source: The Doctors Lounge - Oncology)
Source: The Doctors Lounge - Oncology - June 19, 2018 Category: Cancer & Oncology Tags: Endocrinology, Family Medicine, Geriatrics, Gastroenterology, Internal Medicine, Oncology, Journal, Source Type: news

Recent-Onset Diabetes Tied to Increased Pancreatic Cancer Risk
TUESDAY, June 19, 2018 -- Recent-onset diabetes is associated with more than a two-fold greater increase in risk of pancreatic cancer (PC) than long-standing diabetes in African-Americans and Latinos, according to a study published online June 18 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - June 19, 2018 Category: Pharmaceuticals Source Type: news

Late onset diabetes may be sign of pancreatic cancer
The onset of diabetes in people over 50 years old may be an indicator of pancreatic cancer, according to research published in theJournal of the National Cancer Institute.CNN (Source: Society for Endocrinology)
Source: Society for Endocrinology - June 19, 2018 Category: Endocrinology Source Type: news

Recent-Onset Diabetes May Be Early Sign of Pancreatic Cancer Recent-Onset Diabetes May Be Early Sign of Pancreatic Cancer
African Americans and Latinos with recent-onset diabetes have a much higher risk of developing pancreatic cancer than their counterparts without diabetes.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 19, 2018 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Mayo Clinic discovers gene mutations linked to pancreatic cancer
(Mayo Clinic) Six genes contain mutations that may be passed down in families, substantially increasing a person's risk for pancreatic cancer. That's according to Mayo Clinic research published in the June 19 edition of the JAMA. However, because researchers found these genetic mutations in patients with no family history of pancreatic cancer, they are recommending genetic testing for all pancreatic cancer patients as the new standard of care. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 19, 2018 Category: International Medicine & Public Health Source Type: news

Mayo Clinic discovers gene mutations linked to pancreatic cancer, calls for expanded testing
ROCHESTER, Minn. ? Six genes contain mutations that may be passed down in families, substantially increasing a person?s risk for pancreatic cancer. That's according to Mayo Clinic research published in the June 19 edition of the JAMA. However, because researchers found these genetic mutations in patients with no family history of pancreatic cancer, they are [...] (Source: Mayo Clinic Minnesota News)
Source: Mayo Clinic Minnesota News - June 19, 2018 Category: Hospital Management Source Type: news

Recent-onset diabetes linked to pancreatic cancer for some minorities
Recent-onset type 2 diabetes has been linked to pancreatic cancer in African Americans and Hispanics older than 50, according to a study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 18, 2018 Category: Consumer Health News Source Type: news

Recent-onset diabetes linked to pancreatic cancer in African-Americans, Hispanics
Recent-onset type 2 diabetes has been linked to pancreatic cancer in African Americans and Hispanics older than 50, according to a study. (Source: Health News - UPI.com)
Source: Health News - UPI.com - June 18, 2018 Category: Consumer Health News Source Type: news

Diabetes in middle age may be an early sign of pancreatic cancer
University of Southern California researchers claim being diagnosed with type 2 diabetes after the age of 50 could be a sign of pancreatic cancer as rates are higher than in long-term diabetics. (Source: the Mail online | Health)
Source: the Mail online | Health - June 18, 2018 Category: Consumer Health News Source Type: news

Diabetes after 50 could be early sign of pancreatic cancer
The onset of diabetes after the age of 50 could be an early sign of pancreatic cancer, a new study suggests. (Source: CNN.com - Health)
Source: CNN.com - Health - June 18, 2018 Category: Consumer Health News Source Type: news

Diabetes may be an early manifestation of pancreatic cancer
(Oxford University Press USA) A new study in the Journal of the National Cancer Institute indicates that recent-onset type 2 diabetes may be early expression of pancreatic cancer. Diabetes was associated with a more than twofold higher risk of pancreatic cancer in African-Americans and Latinos, but recent-onset diabetes was associated with a 2.3-fold greater increase in risk of pancreatic cancer than long-standing diabetes. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 18, 2018 Category: International Medicine & Public Health Source Type: news

Diabetes diagnosis may signal early pancreatic cancer in older African-Americans, Latinos
(University of Southern California - Health Sciences) A new study from the Keck School of Medicine of USC shows that African-Americans and Latinos who are diagnosed with diabetes after age 50 have a more than threefold risk of developing pancreatic cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - June 17, 2018 Category: Cancer & Oncology Source Type: news

Should mFOLFIRINOX Be Standard of Care in Adjuvant Tx of Pancreatic Cancer?
Compared with gemcitabine, mFOLFIRINOX improved outcomes for all endpoints when used in the adjuvant setting. (Source: CancerNetwork)
Source: CancerNetwork - June 14, 2018 Category: Cancer & Oncology Authors: Cancer Network Editors Source Type: news