In Regard to Parikh et al.
We found the phase 2 trial by Parikh et al1 on ablative, 5-fraction, stereotactic magnetic resonance –guided, on-table adaptive radiation therapy (MRgRT-SMART) intriguing. Although we acknowledge MRgRT-SMART's promise, we emphasize the need for caution in suggesting its effect on disease management unless robust evidence is provided. Despite the authors not positioning MRgRT-SMART as the primary reference technology for pancreatic cancer, there may be an overemphasis on the widespread interpretation of this evidence. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - April 15, 2024 Category: Radiology Authors: Francesco Cellini, Michele Fiore Tags: Letters to the Editor Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology : WJG)
Source: World Journal of Gastroenterology : WJG - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Treatment patterns and survival outcomes in patients with non-metastatic early-onset pancreatic cancer
CONCLUSION: AT improves postoperative survival in localized patients. Surgery after NAT and RCT are the preferred therapeutic options for patients with locally advanced EOPC.PMID:38617739 | PMC:PMC11008379 | DOI:10.3748/wjg.v30.i12.1739 (Source: World Journal of Gastroenterology)
Source: World Journal of Gastroenterology - April 15, 2024 Category: Gastroenterology Authors: Le-Tian Zhang Ying Zhang Bi-Yang Cao Chen-Chen Wu Jing Wang Source Type: research
Cancers, Vol. 16, Pages 1504: Clinical and Diagnostic Utility of Genomic Profiling for Digestive Cancers: Real-World Evidence from Japan
Hajime Kuroda
Seigo Yukisawa
Takuya Aoki
Kei Takeshita
Shinichi Ueno
Junichi Nakazawa
Yu Sunakawa
Sachio Nohara
Chihiro Okada
Ko Nishimiya
Shigeki Tanishima
Hiroshi Nishihara
The usefulness of comprehensive genomic profiling (CGP) in the Japanese healthcare insurance system remains underexplored. Therefore, this large-scale study aimed to determine the usefulness of CGP in diagnosing digestive cancers. Patients with various cancer types recruited between March 2020 and October 2022 underwent the FoundationOne® CDx assay at the Keio PleSSision Group (19 hospitals in Japan). A scoring sy...
Source: Cancers - April 15, 2024 Category: Cancer & Oncology Authors: Marin Ishikawa Kohei Nakamura Ryutaro Kawano Hideyuki Hayashi Tatsuru Ikeda Makoto Saito Yo Niida Jiichiro Sasaki Hiroyuki Okuda Satoshi Ishihara Masatoshi Yamaguchi Hideaki Shimada Takeshi Isobe Yuki Yuza Akinobu Yoshimura Hajime Kuroda Seigo Yukisawa Ta Tags: Article Source Type: research
Stromal rigidity stress accelerates pancreatic intraepithelial neoplasia progression and chromosomal instability via nuclear PTK2 localization
Since the mechanotransduction by stromal stiffness stimulates the rupture and repair of the nuclear envelope in pancreatic progenitor cells, accumulated genomic aberrations are under selection in the tumor microenvironment. Analysis of cell growth, micronuclei, and γH2AX foci links to mechanotransduction pressure in vivo during serial orthotopic passages of mouse KrasLSL-G12D/+;Trp53flox/flox;Pdx1-Cre (KPC) cancer cells in the tumor and in migrating through the size-restricted 3μm micropores. To search for pancreatic cancer cell-of-origin, analysis of single -cell datasets revealed that the ECM shapes an alternate route ...
Source: American Journal of Pathology - April 15, 2024 Category: Pathology Authors: Li-Yun Ding, Chia-Jung Chang, Szu-Ying Chen, Kuan-Lin Chen, Yueh-Shan Li, Yun-Chieh Wu, Ting-Yi Hsu, Hsin-Yu Ying, Hsin-Yi Wu, Michael, W. Hughes, Chia-Yih Wang, Chih-Han Chang, Ming-Jer Tang, Woei-Jer Chuang, Yan-Shen Shan, Chia-Jung Chang, Po-Hsien Huan Tags: Regular Article Source Type: research
CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival
This study highlights the importance of CD200 expression in pancreatic cancer and provides the rationale for designing novel therapeutic strategies that target this protein. (Source: Cancer Immunology, Immunotherapy)
Source: Cancer Immunology, Immunotherapy - April 15, 2024 Category: Cancer & Oncology Source Type: research
Aspects and outcomes of surveillance for individuals at high-risk of pancreatic cancer
AbstractPancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related deaths and is associated with a poor prognosis. The majority of these cancers are detected at a late stage, contributing to the bad prognosis. This underscores the need for novel, enhanced early detection strategies to improve the outcomes. While population-based screening is not recommended due to the relatively low incidence of PDAC, surveillance is recommended for individuals at high risk for PDAC due to their increased incidence of the disease. However, the outcomes of pancreatic cancer surveillance in high-risk individuals are not sor...
Source: Familial Cancer - April 15, 2024 Category: Cancer & Oncology Source Type: research
Establishment, characterization, and biobanking of 36 pancreatic cancer organoids: prediction of metastasis in resectable pancreatic cancer
ConclusionsThese data suggest that the presence of metastatic PDAC can be identified by integrating molecular compositions and drug responses of borderline resectable PDAC. (Source: Cellular Oncology)
Source: Cellular Oncology - April 15, 2024 Category: Cancer & Oncology Source Type: research
Invited commentary for “Meta-analysis of adjuvant chemotherapy versus no adjuvant chemotherapy for resected stage I pancreatic cancer
Evans et al performed a meta-analysis of 6 observational studies published over a 5-year period ending in 2022 in an attempt to capture associations between adjuvant systemic chemotherapy and overall survival for nearly 7,000 patients with stage IA and IB pancreatic ductal adenocarcinoma who underwent cura tive-intent resection. Using proper statistical analysis with Preferred Reporting Items for Systematic Reviews and Meta-Analyses standards and Risk Of Bias In Non-randomised Studies - of Interventions assessment tools for bias, the authors demonstrated that the use of adjuvant systemic chemotherapy was associated with ...
Source: Surgery - April 15, 2024 Category: Surgery Authors: Michael G. House Source Type: research
Head-to-head comparison of [18F]FDG PET and [68Ga]Ga-FAPI-04 PET in the diagnosis of gastric and pancreatic cancer: a systematic review and meta-analysis
Conclusion[68Ga]Ga-FAPI-04 PET exhibited a higher positivity rate compared to [18F]FDG PET in the detection of primary gastric cancer, lymph node and peritoneal metastases. For pancreatic cancer, both [18F]FDG PET and [68Ga]Ga-FAPI-04 PET demonstrated comparable, high positivity rates for primary cancer diagnosis and lymph node metastasis detection. There is still a requirement for more extensive and forward-looking research in this field. (Source: Clinical and Translational Imaging)
Source: Clinical and Translational Imaging - April 15, 2024 Category: Radiology Source Type: research
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340577. Online ahead of print.ABSTRACTChronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed to study the association between inflammatory response and prognosis in patients with PDAC. We conducted the whole transcriptomic sequencing using tissue samples collected from patients diagnosed with PDAC (n = 106) recruited from Shandong Cancer Hospital. We first constructed a prognostic signature using 15 inflammation-related ge...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Xiaofeng Sun Hao Song Xiaoran Sun Chunhua Liao Guoqiang Wang Yu Xu Leo Li Yusheng Han Chunwei Xu Wenxian Wang Shangli Cai Hua Liang Hao Yu Source Type: research
Cancers, Vol. 16, Pages 1497: Evaluation of Helium Ion Radiotherapy in Combination with Gemcitabine in Pancreatic Cancer In Vitro
Conclusion: Our results demonstrate the cytotoxic efficacy of helium ion radiotherapy in pancreatic cancer in vitro as well as the capability of mMKM calculation and its value for biological plan optimization in helium ion therapy for pancreatic cancer. A combined treatment of helium irradiation and chemotherapy with gemcitabine leads to mainly additive cytotoxic effects in pancreatic cancer cell lines. The data generated in this study may serve as the radiobiological basis for future experimental and clinical works using helium ion radiotherapy in pancreatic cancer treatment. (Source: Cancers)
Source: Cancers - April 14, 2024 Category: Cancer & Oncology Authors: Bahar Cepni Thomas Tessonnier Ivana Dokic Stephan Brons Bouchra Tawk Andrea Mairani Amir Abdollahi J ürgen Debus Klaus Herfarth Jakob Liermann Tags: Article Source Type: research
Pancreatic ductal adenocarcinoma: exploring clinicopathological trends and racial disparities in a comprehensive U.S. population-based study
ConclusionPDAC is an aggressive malignancy with male gender and black race are associated with a poor prognosis. Surgery with chemoradiation was associated with the best overall survival. With steadily increasing rates of PDAC, improved treatment modalities are paramount to improving survival in these patients. (Source: Clinical and Translational Oncology)
Source: Clinical and Translational Oncology - April 14, 2024 Category: Cancer & Oncology Source Type: research
Estimating the Prognostic Value of the NTRK Fusion Biomarker for Comparative Effectiveness Research in The Netherlands
ConclusionsNTRK+ patients may have an increased risk of death compared withNTRK − patients. When using historic control data to assess the comparative effectiveness of TRK inhibitors, the prognostic value of theNTRK fusion biomarker should therefore be accounted for. (Source: Molecular Diagnosis and Therapy)
Source: Molecular Diagnosis and Therapy - April 14, 2024 Category: Molecular Biology Source Type: research
Proton Pump Inhibitors and Cancer Risk: A Comprehensive Review of Epidemiological and Mechanistic Evidence
Conclusions: Despite the well-established cancer risk associated with PPIs, it is notable that these medications continue to be widely prescribed for periods longer than 3 months. Thus, it is of paramount importance for clinicians and patients to thoughtfully evaluate the potential risks and benefits of long-term PPI usage and explore alternative treatments before making informed decisions regarding their medical management.PMID:38610738 | DOI:10.3390/jcm13071970 (Source: Clinical Colorectal Cancer)
Source: Clinical Colorectal Cancer - April 13, 2024 Category: Cancer & Oncology Authors: Ibrahim O Sawaid Abraham O Samson Source Type: research
