Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
LyGenesis Commences Phase II Trial for Growth of Liver Organoids in Patient Lymph Nodes
LyGenesis has been working towards liver organoid transplantation as a treatment for liver failure for some years now. Organs such as the liver, thymus, and a few others do not need to be in any specific place in the body to carry out many of their varied functions. Some of the vital work of the liver, for example, can be conducted in small organoids grown from liver cells transplanted into lymph nodes or other parts of the body that can act as stable bioreactors.
Even setting aside the possibility of growing functional liver organoids from patient cells or universal cell lines, it is worth noting that the old appro...
Source: Fight Aging! - April 9, 2024 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Palliative and hospice care in hospitals and clinics: the good, the bad, and the ugly
I walk into the patient’s hospital room during evening rounds. He looks pale and tired, having recently completed a round of chemotherapy for his stage IV pancreatic cancer. His wife is at the bedside, scared and concerned about her husband’s rapid decline. I sit down to discuss goals of care when the patient immediately says,
Read more…
Palliative and hospice care in hospitals and clinics: the good, the bad, and the ugly originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - April 1, 2024 Category: General Medicine Authors: Earl Stewart, Jr., MD & America ’s nurses have PTSD: Will anyone listen to them?
My first clinical rotation as a nursing student was on the same floor where my mother died of cancer. And my very first patient was a young Hispanic man with four children. I was asked to tell him that he had pancreatic cancer and very little time left. I was 21 years old and the
Read more…
America’s nurses have PTSD: Will anyone listen to them? originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - March 9, 2024 Category: General Medicine Authors: Tara Rynders, RN Tags: Conditions Nursing Psychiatry Source Type: blogs
Fight Aging! Newsletter, March 4th 2024
In conclusion, HSV (but not CMV) infection may be indicative of doubled dementia risk.
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Increased Dietary Leucine Activates mTOR Signaling in Macrophages, Accelerating Atherosclerosis
https://www.fightaging.org/archives/2024/02/increased-dietary-leucine-activates-mtor-signaling-in-macrophages-accelerating-atherosclerosis/
Leucine is an essential amino acid, only obtained from the diet rather than synthesized by our cells. Leucine supplementation has been proposed as a way to slow the loss of muscle mass with age, as leucine processing becomes dysregulated with aging in a way...
Source: Fight Aging! - March 3, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aged Pancreatic Fibroblasts Secrete GDF-15, Encouraging Tumor Growth
Researchers here note one of a broad range of examples in which age-related changes in the state and behavior of non-cancerous cells results in a more hospitable environment for the growth of neighboring cancerous tissue. Cancer is an age-related condition not just because of increased damage to cells in older tissues, nor just because the immune system falters in its surveillance of potentially cancerous cells, but also due to other maladaptive changes that favor the metabolism and growth of some forms of cancerous cells.
A new study provides clues as to why pancreatic cancer is more common and aggressive in olde...
Source: Fight Aging! - February 28, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The 6 Most Exciting Medical Technology Breakthroughs Of Recent Years
Amidst the flurry of hyped technologies, it’s not easy to pinpoint which specific technological breakthroughs will have the most impact in the coming years.
Dr. Meskó, The Medical Futurist, reviews multiple reports, studies, and articles daily. Consequently, our days are filled with awe-inspiring developments. However, our aim here is to offer more than just a compilation of “wow, look how fascinating” stories.
To achieve this, we have selected technologies that:
Have undergone significant breakthroughs in recent years, be it in regulatory, technological, or scientific aspects
Are anticipate...
Source: The Medical Futurist - January 9, 2024 Category: Information Technology Authors: Andrea Koncz Tags: TMF artificial intelligence digital health future Healthcare Source Type: blogs
How Can the Immune System Go Awry?
This post is part of a miniseries on the immune system. Be sure to check out the other posts in this series that you may have missed.
The immune system is designed to closely monitor the body for signs of intruders that may cause infection. But what happens if it malfunctions? Overactive and underactive immune systems can both have negative effects on your health.
Autoimmune Disorders
To effectively monitor the body for pathogens, the adaptive immune system has to learn what a pathogen “looks like” on a molecular level. During their development, white blood cells go through training to learn how to differe...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - January 8, 2024 Category: Research Authors: Chrissa Chverchko Tags: Cells Injury and Illness Diseases Immunology Miniseries Infectious Diseases Microbes Sepsis Source Type: blogs
Deconstructing diabetes stigma: A panel discussion
In conclusion, the discussion was an enriching and eye-opening event, bringing together passionate individuals dedicated to challenging the stigma around diabetes. By amplifying our voices and working together, we can make a lasting impact on the lives of those touched by diabetes.Visit enddiabetesstigma.org and become a part of the movement for change. If you’d like to get involved in spreading more awareness about this, reach out to Dennis and/or leave a comment here.
Full transcript and show notes
...
Source: Scott's Diabetes Blog - January 4, 2024 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs
Fight Aging! Newsletter, January 1st 2024
Discussion of What is Need to Speed the Pace at which Drugs to Treat Aging Arrive in the Clinic
Cellular Senescence in the Aging Brain, a Contributing Cause of Cognitive Decline
Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Blunt Thoughts on Calculating the Revealed Value of Human Life
A Look Back at 2023: Progress Towards the Treatment of Aging as a Medical Condition
Towards Adjustment of the Gut Microbiome to Slow Aging
Gene Therapy Enhances Object Recognition Memory in Young and Old Mice
Benefits of Sem...
Source: Fight Aging! - December 31, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The State Of CRISPR Clinical Trials And Their Future Potentials
CRISPR, short for “Clustered Regularly Interspaced Short Palindromic Repeats” – and more specifically CRISPR–Cas9 – relates to a gene-editing method that gained popularity in the past decade; and not for trivial reasons. Being the most efficient and accurate method to edit a cell’s genome, CRISPR holds potentials that range from treating conditions such as HIV to finding new drug targets.
While such potentials are real and are being actively investigated, you might be curious about more practical examples of CRISPR applications. By taking the US Clinical Trials registry as an example, we consider lis...
Source: The Medical Futurist - December 7, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF CRISPR therapy clinical trials gene editing Source Type: blogs
This Is Good News About A Cancer None Of Us Ever Want!
I, for one, would leap at an annual blood test to avoid this
horror!
Scientists to develop first ever blood test
for pancreatic cancer
By Joanna Panagopoulos 10:15PM November 16, 2023 Australian researchers are close to developing the first blood test for the “silent killer” pancreatic can cer. Scientists from the Walter and Eliza Hall Institute of Medical Research in Melbourne believe a (Source: Australian Health Information Technology)
Source: Australian Health Information Technology - November 22, 2023 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
