Corrigendum to "Distinctive domains and activity regulation of core fucosylation enzyme FUT8" [BBA General Subjects 1868 (2024)/130561]
Biochim Biophys Acta Gen Subj. 2024 Apr 13:130615. doi: 10.1016/j.bbagen.2024.130615. Online ahead of print.NO ABSTRACTPMID:38614919 | DOI:10.1016/j.bbagen.2024.130615 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 13, 2024 Category: Biochemistry Authors: Seita Tomida Masamichi Nagae Yasuhiko Kizuka Source Type: research
Extracellular vesicles in cancer therapy: Roles, potential application, and challenges
Biochim Biophys Acta Rev Cancer. 2024 Apr 10:189101. doi: 10.1016/j.bbcan.2024.189101. Online ahead of print.ABSTRACTExtracellular vesicles (EVs) have emerged as a novel cell-free strategy for the treatment of many diseases including cancer as they play important roles in cancer development and progression. Considering their natural capacity to facilitate cell-to-cell communication as well as their high physiochemical stability and biocompatibility, EVs serve as superior delivery systems for a wide range of therapeutic agents, including medicines, nanomaterials, nucleic acids, and proteins. Therefore, EVs-based cancer ther...
Source: Biochimica et Biophysica Acta - April 12, 2024 Category: Biochemistry Authors: Ting Liu Li Sun Yong Ji Wei Zhu Source Type: research
Sea cucumber plasmalogen enhance lipophagy to alleviate abnormal lipid accumulation induced by high-fat diet
Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr 10;1869(5):159495. doi: 10.1016/j.bbalip.2024.159495. Online ahead of print.ABSTRACTSea cucumber phospholipids, including the plasmalogen (PlsEtn) and plasmanylcholine (PakCho), have been shown to play a regulatory role in lipid metabolism disorders, but their mechanism of action remains unclear. Therefore, high-fat diet (HFD) and palmitic acid were used to establish lipid accumulation models in mice and HepG2 cells, respectively. Results showed that PlsEtn can reduce lipid deposition both in vivo and in vitro. HFD stimulation abnormally activated lipophagy through the ph...
Source: Biochimica et Biophysica Acta - April 12, 2024 Category: Biochemistry Authors: Zhigao Wang Yanjun Liu Xiaoxu Wang Xincen Wang Yuan Wu Yu Song Jie Xu Changhu Xue Source Type: research
A role for RIO kinases in the crosshair of cancer research and therapy
Biochim Biophys Acta Rev Cancer. 2024 Apr 9;1879(3):189100. doi: 10.1016/j.bbcan.2024.189100. Online ahead of print.ABSTRACTRIO (right open reading frame) family of kinases including RIOK1, RIOK2 and RIOK3 are known for their role in the ribosomal biogenesis. Dysfunction of RIO kinases have been implicated in malignancies, including acute myeloid leukemia, glioma, breast, colorectal, lung and prostatic adenocarcinoma suggesting RIO kinases as potential targets in cancer. In vitro, in vivo and clinical studies have demonstrated that RIO kinases are overexpressed in various types of cancers suggesting important roles in tumo...
Source: Biochimica et Biophysica Acta - April 11, 2024 Category: Biochemistry Authors: Morteza Ghandadi Albert Dobi Sanjay V Malhotra Source Type: research
Zinc finger protein 36 like 2-histone deacetylase 1 axis is involved in the bone responses to mechanical stress
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 9:167162. doi: 10.1016/j.bbadis.2024.167162. Online ahead of print.ABSTRACTThe molecular mechanism underlying the promotion of fracture healing by mechanical stimuli remains unclear. The present study aimed to investigate the role of zinc finger protein 36 like 2 (ZFP36L2)-histone deacetylase 1 (HDAC1) axis on the osteogenic responses to moderate mechanical stimulation. Appropriate stimulation of fluid shear stress (FSS) was performed on MC3T3-E1 cells transduced with ZFP36L2 and HDAC1 recombinant adenoviruses, aiming to validate the influence of mechanical stress on the express...
Source: Biochimica et Biophysica Acta - April 11, 2024 Category: Biochemistry Authors: Bin Wang Wei Wang Jingyu Li Jianjun Li Source Type: research
A role for RIO kinases in the crosshair of cancer research and therapy
Biochim Biophys Acta Rev Cancer. 2024 Apr 9:189100. doi: 10.1016/j.bbcan.2024.189100. Online ahead of print.ABSTRACTRIO (right open reading frame) family of kinases including RIOK1, RIOK2 and RIOK3 are known for their role in the ribosomal biogenesis. Dysfunction of RIO kinases have been implicated in malignancies, including acute myeloid leukemia, glioma, breast, colorectal, lung and prostatic adenocarcinoma suggesting RIO kinases as potential targets in cancer. In vitro, in vivo and clinical studies have demonstrated that RIO kinases are overexpressed in various types of cancers suggesting important roles in tumorigenesi...
Source: Biochimica et Biophysica Acta - April 11, 2024 Category: Biochemistry Authors: Morteza Ghandadi Albert Dobi Sanjay V Malhotra Source Type: research
Zinc finger protein 36 like 2-histone deacetylase 1 axis is involved in the bone responses to mechanical stress
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 9:167162. doi: 10.1016/j.bbadis.2024.167162. Online ahead of print.ABSTRACTThe molecular mechanism underlying the promotion of fracture healing by mechanical stimuli remains unclear. The present study aimed to investigate the role of zinc finger protein 36 like 2 (ZFP36L2)-histone deacetylase 1 (HDAC1) axis on the osteogenic responses to moderate mechanical stimulation. Appropriate stimulation of fluid shear stress (FSS) was performed on MC3T3-E1 cells transduced with ZFP36L2 and HDAC1 recombinant adenoviruses, aiming to validate the influence of mechanical stress on the express...
Source: Biochimica et Biophysica Acta - April 11, 2024 Category: Biochemistry Authors: Bin Wang Wei Wang Jingyu Li Jianjun Li Source Type: research
CAMSAP3-mediated regulation of HMGB1 acetylation and subcellular localization in lung cancer cells: Implications for cell death modulation
CONCLUSIONS: CAMSAP3 is prerequisite for TSA-mediated autophagic cell death by interacting with cytoplasmic acetylated HMGB1 and enhancing its release.SIGNIFICANT: This finding provides molecular insights into the role of CAMSAP3 in regulating cell death, highlighting its potential as a therapeutic target for lung cancer treatment.PMID:38598971 | DOI:10.1016/j.bbagen.2024.130614 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Natsaranyatron Singharajkomron Suthasinee Seephan Iksen Iksen Naphat Chantaravisoot Piriya Wongkongkathep Yoshihiro Hayakawa Varisa Pongrakhananon Source Type: research
Metabolic adaptations in cancer stem cells: A key to therapy resistance
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167164. doi: 10.1016/j.bbadis.2024.167164. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor growth and cause recurrence and metastasis. CSCs are particularly resistant to conventional therapies compared to their counterparts, owing greatly to their intrinsic metabolic plasticity. Metabolic plasticity allows CSCs to switch between different energy production and usage pathways based on environmental and extrinsic factors, including conditions imposed by conventional cancer therapies. To cope with nutrient dep...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Matthew Masoudi Dilpreet Moti Raha Masoudi Abdul Auwal M Matakabbir Hossain Tasfik Ul Haque Pronoy Khan Mohammad Rashel Vinod Gopalan Farhadul Islam Source Type: research
The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167161. doi: 10.1016/j.bbadis.2024.167161. Online ahead of print.ABSTRACTThe tongue epithelium is maintained by a proliferative basal layer. This layer contains long-lived stem cells (SCs), which produce progeny cells that move up to the surface as they differentiate. B-lymphoma Mo-MLV insertion region 1 (Bmi1), a protein in mammalian Polycomb Repressive Complex 1 (PRC1) and a biomarker of oral squamous cell carcinoma, is expressed in almost all basal epithelial SCs of the tongue, and single, Bmi1-labelled SCs give rise to cells in all epithelial layers. We previously develope...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Jorge Baquero Xiao-Han Tang Annalisa Ferrotta Tuo Zhang Krysta M DiKun Lorraine J Gudas Source Type: research
Transcriptomic analysis identifies dysregulated pathways and therapeutic targets in PMM2-CDG
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167163. doi: 10.1016/j.bbadis.2024.167163. Online ahead of print.ABSTRACTPMM2-CDG (MIM # 212065), the most common congenital disorder of glycosylation, is caused by the deficiency of phosphomannomutase 2 (PMM2). It is a multisystemic disease of variable severity that particularly affects the nervous system; however, its molecular pathophysiology remains poorly understood. Currently, there is no effective treatment. We performed an RNA-seq based transcriptomic study using patient-derived fibroblasts to gain insight into the mechanisms underlying the clinical symptomatology and ...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Diana Gallego Mercedes Serrano Jose Cordoba-Caballero Alejandra G ámez Pedro Seoane James R Perkins Juan A G Ranea Bel én Pérez Source Type: research
Iron ‑sulfur clusters in viral proteins: Exploring their elusive nature, roles and new avenues for targeting infections
Biochim Biophys Acta Mol Cell Res. 2024 Apr 8:119723. doi: 10.1016/j.bbamcr.2024.119723. Online ahead of print.ABSTRACTViruses have evolved complex mechanisms to exploit host factors for replication and assembly. In response, host cells have developed strategies to block viruses, engaging in a continuous co-evolutionary battle. This dynamic interaction often revolves around the competition for essential resources necessary for both host cell and virus replication. Notably, iron, required for the biosynthesis of several cofactors, including iron‑sulfur (FeS) clusters, represents a critical element in the ongoing competiti...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Nunziata Maio Audrey L Heffner Tracey A Rouault Source Type: research
CAMSAP3-mediated regulation of HMGB1 acetylation and subcellular localization in lung cancer cells: Implications for cell death modulation
CONCLUSIONS: CAMSAP3 is prerequisite for TSA-mediated autophagic cell death by interacting with cytoplasmic acetylated HMGB1 and enhancing its release.SIGNIFICANT: This finding provides molecular insights into the role of CAMSAP3 in regulating cell death, highlighting its potential as a therapeutic target for lung cancer treatment.PMID:38598971 | DOI:10.1016/j.bbagen.2024.130614 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Natsaranyatron Singharajkomron Suthasinee Seephan Iksen Iksen Naphat Chantaravisoot Piriya Wongkongkathep Yoshihiro Hayakawa Varisa Pongrakhananon Source Type: research
Metabolic adaptations in cancer stem cells: A key to therapy resistance
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167164. doi: 10.1016/j.bbadis.2024.167164. Online ahead of print.ABSTRACTCancer stem cells (CSCs) are a subset of tumor cells that can initiate and sustain tumor growth and cause recurrence and metastasis. CSCs are particularly resistant to conventional therapies compared to their counterparts, owing greatly to their intrinsic metabolic plasticity. Metabolic plasticity allows CSCs to switch between different energy production and usage pathways based on environmental and extrinsic factors, including conditions imposed by conventional cancer therapies. To cope with nutrient dep...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Matthew Masoudi Dilpreet Moti Raha Masoudi Abdul Auwal M Matakabbir Hossain Tasfik Ul Haque Pronoy Khan Mohammad Rashel Vinod Gopalan Farhadul Islam Source Type: research
The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 8:167161. doi: 10.1016/j.bbadis.2024.167161. Online ahead of print.ABSTRACTThe tongue epithelium is maintained by a proliferative basal layer. This layer contains long-lived stem cells (SCs), which produce progeny cells that move up to the surface as they differentiate. B-lymphoma Mo-MLV insertion region 1 (Bmi1), a protein in mammalian Polycomb Repressive Complex 1 (PRC1) and a biomarker of oral squamous cell carcinoma, is expressed in almost all basal epithelial SCs of the tongue, and single, Bmi1-labelled SCs give rise to cells in all epithelial layers. We previously develope...
Source: Biochimica et Biophysica Acta - April 10, 2024 Category: Biochemistry Authors: Jorge Baquero Xiao-Han Tang Annalisa Ferrotta Tuo Zhang Krysta M DiKun Lorraine J Gudas Source Type: research
